CN104736167B - 含有mhc i型启动子的慢病毒载体 - Google Patents

含有mhc i型启动子的慢病毒载体 Download PDF

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CN104736167B
CN104736167B CN201380026705.4A CN201380026705A CN104736167B CN 104736167 B CN104736167 B CN 104736167B CN 201380026705 A CN201380026705 A CN 201380026705A CN 104736167 B CN104736167 B CN 104736167B
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promoter
slow virus
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CN104736167A (zh
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E·萨莉
C·伯奇
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Sai Lafukedisi Co
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    • C12N2740/10011Retroviridae
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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CN201380026705.4A 2012-05-23 2013-04-30 含有mhc i型启动子的慢病毒载体 Active CN104736167B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305566.7 2012-05-23
EP12305566.7A EP2666477A1 (en) 2012-05-23 2012-05-23 Lentiviral vectors containing an MHC class I promoter
PCT/EP2013/059041 WO2013174630A1 (en) 2012-05-23 2013-04-30 Lentiviral vectors containing an mhc class i promoter

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CN104736167A CN104736167A (zh) 2015-06-24
CN104736167B true CN104736167B (zh) 2018-07-27

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US (1) US8951535B2 (https=)
EP (2) EP2666477A1 (https=)
JP (1) JP5938143B2 (https=)
KR (1) KR101774929B1 (https=)
CN (1) CN104736167B (https=)
AU (1) AU2013265586B2 (https=)
BR (1) BR112014028944B1 (https=)
CA (1) CA2873473C (https=)
ES (1) ES2498277T3 (https=)
IL (1) IL235705A (https=)
IN (1) IN2014DN10123A (https=)
NZ (1) NZ702345A (https=)
PL (1) PL2678032T3 (https=)
PT (1) PT2678032E (https=)
SG (1) SG11201407732SA (https=)
WO (1) WO2013174630A1 (https=)
ZA (1) ZA201408652B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015030211A2 (pt) 2013-06-03 2017-08-22 Theravectys Vetores lentivirais contendo uma sequência promotora a montante da mhc de classe i, mhc de classe ii ou microglobulina beta-2
EP3276006A1 (en) * 2016-07-27 2018-01-31 Theravectys Lentiviral vectors for expression of hepatitis b virus (hbv) antigens
KR102932097B1 (ko) 2020-07-06 2026-02-27 주식회사 지씨셀 면역원성이 감소된 신규한 이식용 세포
CN114107393A (zh) 2021-04-07 2022-03-01 上海劲威生物科技有限公司 一种治疗乙型肝炎的慢病毒载体、慢病毒颗粒及其制备方法和应用
KR102913951B1 (ko) * 2022-11-10 2026-01-20 전남대학교 산학협력단 다중에피토프 펩타이드를 포함하는 신경교종 예방 또는 치료용 약제학적 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19720152A1 (de) * 1997-05-02 1998-11-05 Max Delbrueck Centrum Retrovirales Vektorsystem zur Optimierung des Gentransfers und der Genexpression in primären humanen T-Lymphozyten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2777909B1 (fr) 1998-04-24 2002-08-02 Pasteur Institut Utilisation de sequences d'adn de structure triplex pour le tranfert de sequences de nucleotides dans des cellules, vecteurs recombinants contenant ces sequences triplex
ATE449858T1 (de) 1999-10-11 2009-12-15 Pasteur Institut Lentivirale vektoren für die herstellung von immunotherapeutischen zusammensetzungen
ATE351916T1 (de) 1999-10-12 2007-02-15 Pasteur Institut Lentivirale triplex-dns, und vektoren und rekombinante zellen, die lentivirale triplex-dns enthalten
FR2870126B1 (fr) 2004-05-17 2009-07-17 Pasteur Institut Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin
US8222029B2 (en) 2005-05-16 2012-07-17 Institut Pasteur Lentiviral vector-based vaccine
ES2708856T3 (es) 2007-08-03 2019-04-11 Pasteur Institut Vectores de transferencia de gen lentivírico y sus aplicaciones medicinales

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19720152A1 (de) * 1997-05-02 1998-11-05 Max Delbrueck Centrum Retrovirales Vektorsystem zur Optimierung des Gentransfers und der Genexpression in primären humanen T-Lymphozyten

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Adenovirus Type 12 ElA Down Regulates Expression of a Transgene under Control of a Major Histocompatibility Complex Class I Promoter: Evidence for Transcriptional Control;INGEBORG MEIJER等;《JOURNAL OF VIROLOGY》;19890930;第63卷(第9期);第4039-4042页 *
Establishment and Characterization of Conditionally Immortalized Stromal Cell Lines from a Temperature-Sensitive T-Ag Transgenic Mouse;DOMINIK FEUERBACH等;《JOURNAL OF BONE AND MINERAL RESEARCH》;19971231;第12卷(第2期);正文第180页第20-28行, *
Human papillomavirus type 16 (HPV 16) E7 and major histocompatibility complex (MHC) class I and II expression in human keratinocytes in culture;A. Hoos等;《Arch Virol》;19961231;第141卷;第449-458页 *
Interferons Increase Transcription of a Major Histocompatibility Class I Gene via a 5" Interferon Consensus Sequence;KENJI SUGITA等;《MOLECULAR AND CELLULAR BIOLOGY》;19870731;第7卷(第7期);第2626-2630页 *
Lentiviral vectors for cancer immunotherapy:transforming infectious particles into therapeutics;K Breckpot等;《Gene Therapy》;20070322;第14卷;摘要 *
Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells;JAMES R. FLANAGAN等;《Developmental Biology》;19910430;第88卷;第3145-3149页 *

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Publication number Publication date
EP2666477A1 (en) 2013-11-27
KR20150014472A (ko) 2015-02-06
ES2498277T3 (es) 2014-09-24
EP2678032B1 (en) 2014-06-18
IL235705A0 (en) 2015-01-29
BR112014028944A2 (pt) 2015-09-29
PT2678032E (pt) 2014-09-09
US20140120132A1 (en) 2014-05-01
CN104736167A (zh) 2015-06-24
AU2013265586A1 (en) 2014-12-11
CA2873473C (en) 2019-05-07
US8951535B2 (en) 2015-02-10
CA2873473A1 (en) 2013-11-28
PL2678032T3 (pl) 2014-11-28
WO2013174630A1 (en) 2013-11-28
ZA201408652B (en) 2016-09-28
HK1211837A1 (en) 2016-06-03
EP2678032A1 (en) 2014-01-01
IL235705A (en) 2016-10-31
IN2014DN10123A (https=) 2015-08-21
KR101774929B1 (ko) 2017-09-19
SG11201407732SA (en) 2014-12-30
BR112014028944B1 (pt) 2020-11-10
JP5938143B2 (ja) 2016-06-22
JP2015518716A (ja) 2015-07-06
NZ702345A (en) 2016-03-31
AU2013265586B2 (en) 2015-09-03

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