CN104717962B - 包含蛋白质和可生物降解聚酯酰胺的药物递送组合物 - Google Patents

包含蛋白质和可生物降解聚酯酰胺的药物递送组合物 Download PDF

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Publication number
CN104717962B
CN104717962B CN201380051351.9A CN201380051351A CN104717962B CN 104717962 B CN104717962 B CN 104717962B CN 201380051351 A CN201380051351 A CN 201380051351A CN 104717962 B CN104717962 B CN 104717962B
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drug delivery
group
protein
delivery composition
release
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Chinese (zh)
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CN104717962A (zh
Inventor
延斯·克里斯托·蒂斯
乔治·米霍夫
盖伊·德拉亚斯玛
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DSM IP Assets BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201380051351.9A 2012-10-02 2013-10-02 包含蛋白质和可生物降解聚酯酰胺的药物递送组合物 Active CN104717962B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12186915 2012-10-02
EP12186915.0 2012-10-02
EP13173634 2013-06-25
EP13173634.0 2013-06-25
PCT/EP2013/070543 WO2014053542A1 (en) 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides

Publications (2)

Publication Number Publication Date
CN104717962A CN104717962A (zh) 2015-06-17
CN104717962B true CN104717962B (zh) 2017-07-21

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CN201380051351.9A Active CN104717962B (zh) 2012-10-02 2013-10-02 包含蛋白质和可生物降解聚酯酰胺的药物递送组合物

Country Status (7)

Country Link
US (1) US9789189B2 (enExample)
EP (1) EP2903592B1 (enExample)
JP (1) JP6330815B2 (enExample)
CN (1) CN104717962B (enExample)
CA (1) CA2881729C (enExample)
IN (1) IN2015DN01153A (enExample)
WO (1) WO2014053542A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CA2839526A1 (en) 2011-06-23 2012-12-27 Dsm Ip Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
EP2903592B1 (en) 2012-10-02 2019-01-23 DSM IP Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
US20150328374A1 (en) * 2012-12-20 2015-11-19 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery
EP3233067B1 (en) * 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
US10500318B1 (en) 2018-07-03 2019-12-10 Temple Therapeutics BV Dosing regimens for treating hypoxia-associated tissue damage
JP7570342B2 (ja) 2019-03-05 2024-10-21 アエリエ ファーマシューティカルズ インコーポレイテッド 眼の疾患又は障害を治療するための医薬組成物
JP2024521037A (ja) 2021-05-07 2024-05-28 テンプル セラピューティクス ベスローテン フェンノートシャップ 末梢神経の線維症及び低酸素関連損傷を処置する方法
WO2025163204A1 (en) 2024-02-01 2025-08-07 Temple Therapeutics BV Glutamine source for use in methods and compositions for reducing or preventing synovial joint adhesions or fibrosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008157254A2 (en) * 2007-06-20 2008-12-24 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
CA2419429C (en) * 2000-08-30 2010-07-27 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
CN103619910A (zh) * 2011-06-23 2014-03-05 帝斯曼知识产权资产管理有限公司 用于药物递送的新颖的聚酯酰胺共聚物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550730A (en) 1981-12-07 1985-11-05 Ethicon, Inc. Flexible monofilament surgical sutures comprising poly(polymethylene terephthalate, isophthalate or cyclohexane-1,4-dicarboxylate-co-dimerate)
EP0926184A1 (en) 1997-12-25 1999-06-30 Mitsui Chemicals, Inc. Process for production of polyamino acid derivative
CN1321092A (zh) 1998-06-30 2001-11-07 安姆根有限公司 用于生物活性剂的延缓给药的热敏生物可降解水凝胶
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US7304122B2 (en) 2001-08-30 2007-12-04 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
EP1603485A4 (en) 2003-02-26 2011-03-30 Medivas Llc BIOACTIVE STENTS AND METHOD OF USE THEREOF
US20060024357A1 (en) 2004-05-12 2006-02-02 Medivas, Llc Wound healing polymer compositions and methods for use thereof
JP2005139139A (ja) 2003-11-07 2005-06-02 Idemitsu Technofine Co Ltd 化粧料組成物
US20050271700A1 (en) 2004-06-03 2005-12-08 Desnoyer Jessica R Poly(ester amide) coating composition for implantable devices
AU2005271700B2 (en) 2004-07-12 2010-11-11 Allergan, Inc. Opthalmic compositions and methods for treating ophthalmic conditions
US7390497B2 (en) 2004-10-29 2008-06-24 Advanced Cardiovascular Systems, Inc. Poly(ester amide) filler blends for modulation of coating properties
US20060159918A1 (en) 2004-12-22 2006-07-20 Fiber Innovation Technology, Inc. Biodegradable fibers exhibiting storage-stable tenacity
CN100551950C (zh) 2005-03-21 2009-10-21 中国科学院成都有机化学有限公司 一种可降解聚酯酰胺共聚物的制备方法
US8652504B2 (en) 2005-09-22 2014-02-18 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
EP1957113A4 (en) 2005-11-21 2011-11-09 Medivas Llc POLYMER PARTICLES FOR THE OUTPUT OF MACROMOLECULES AND METHOD OF APPLICATION THEREFOR
US8974815B2 (en) 2005-12-16 2015-03-10 Cornell University Fibrous membrane for biomedical application based on poly(ester-amide)s
TWI376239B (en) 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
US20070292476A1 (en) 2006-05-02 2007-12-20 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
JP5196498B2 (ja) 2006-05-09 2013-05-15 メディバス エルエルシー 生分解性水溶性ポリマー
US8936780B2 (en) 2006-08-30 2015-01-20 Advanced Cardiovascular Systems, Inc. Stimuli responsive polyester amide particles
KR101422298B1 (ko) 2006-09-08 2014-08-13 가부시키가이샤 니콘 마스크, 노광 장치, 노광 방법 및 그 노광 장치 또는 노광 방법을 이용한 디바이스 제조 방법
CN101678041A (zh) 2007-03-30 2010-03-24 梅迪沃什有限公司 可生物吸收的弹性聚合物网络、交联剂以及使用方法
WO2009012449A1 (en) 2007-07-18 2009-01-22 The Board Of Trustees Of The University Of Illinois Temporal release of growth factors from 3d micro rod scaffolds for tissue regeneration
JP5743287B2 (ja) 2009-10-16 2015-07-01 ディーエスエム アイピー アセッツ ビー．ブイ． ビス−（アルファ−アミノ−ジオール−ジエステル）を含有するポリエステルアミドを含むコーティング
JP2013526572A (ja) 2010-05-17 2013-06-24 アエリエ・ファーマシューティカルズ・インコーポレーテッド 眼治療薬の送達のための薬物送達装置
EP2705182B1 (en) 2011-05-02 2018-10-31 DSM IP Assets B.V. Fiber comprising a biodegradable polymer
US20140105957A1 (en) 2011-05-02 2014-04-17 Dsm Ip Assets B.V. Bis-(alpha-amino-diol-diester) containing polyesteramide for ophtamology
EP2790667B1 (en) 2011-12-16 2017-03-22 DSM IP Assets B.V. Process for the manufacturing of a drug delivery system based on a polymer comprising a dispersed bioactive agent
EP2903592B1 (en) 2012-10-02 2019-01-23 DSM IP Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
EP2911647B1 (en) 2012-10-23 2018-03-07 DSM IP Assets B.V. Process for the manufacturing of a multilayer drug delivery construct
US10538864B2 (en) 2012-10-24 2020-01-21 Dsm Ip Assets, B.V. Fibers comprising polyesteramide copolymers for drug delivery
US20150328374A1 (en) 2012-12-20 2015-11-19 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2419429C (en) * 2000-08-30 2010-07-27 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
WO2008157254A2 (en) * 2007-06-20 2008-12-24 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
CN103619910A (zh) * 2011-06-23 2014-03-05 帝斯曼知识产权资产管理有限公司 用于药物递送的新颖的聚酯酰胺共聚物
CN103748139A (zh) * 2011-06-23 2014-04-23 帝斯曼知识产权资产管理有限公司 用于递送生物活性剂的包含生物可降解的聚酯酰胺共聚物的微米颗粒或纳米颗粒

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EP2903592B1 (en) 2019-01-23
CA2881729A1 (en) 2014-04-10
IN2015DN01153A (enExample) 2015-06-26
JP6330815B2 (ja) 2018-05-30
JP2015534557A (ja) 2015-12-03
CN104717962A (zh) 2015-06-17
US20150216987A1 (en) 2015-08-06
US9789189B2 (en) 2017-10-17
EP2903592A1 (en) 2015-08-12
WO2014053542A1 (en) 2014-04-10
CA2881729C (en) 2021-05-04

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