CN104717962B - 包含蛋白质和可生物降解聚酯酰胺的药物递送组合物 - Google Patents

包含蛋白质和可生物降解聚酯酰胺的药物递送组合物 Download PDF

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Publication number
CN104717962B
CN104717962B CN201380051351.9A CN201380051351A CN104717962B CN 104717962 B CN104717962 B CN 104717962B CN 201380051351 A CN201380051351 A CN 201380051351A CN 104717962 B CN104717962 B CN 104717962B
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drug delivery
group
protein
delivery composition
release
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Chinese (zh)
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CN104717962A (zh
Inventor
延斯·克里斯托·蒂斯
乔治·米霍夫
盖伊·德拉亚斯玛
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DSM IP Assets BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201380051351.9A 2012-10-02 2013-10-02 包含蛋白质和可生物降解聚酯酰胺的药物递送组合物 Active CN104717962B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12186915 2012-10-02
EP12186915.0 2012-10-02
EP13173634 2013-06-25
EP13173634.0 2013-06-25
PCT/EP2013/070543 WO2014053542A1 (en) 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides

Publications (2)

Publication Number Publication Date
CN104717962A CN104717962A (zh) 2015-06-17
CN104717962B true CN104717962B (zh) 2017-07-21

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CN201380051351.9A Active CN104717962B (zh) 2012-10-02 2013-10-02 包含蛋白质和可生物降解聚酯酰胺的药物递送组合物

Country Status (7)

Country Link
US (1) US9789189B2 (enExample)
EP (1) EP2903592B1 (enExample)
JP (1) JP6330815B2 (enExample)
CN (1) CN104717962B (enExample)
CA (1) CA2881729C (enExample)
IN (1) IN2015DN01153A (enExample)
WO (1) WO2014053542A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
EP3159368B1 (en) 2011-06-23 2024-07-24 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
WO2014053542A1 (en) 2012-10-02 2014-04-10 Dsm Ip Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
WO2014096339A1 (en) * 2012-12-20 2014-06-26 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery
AU2015366355B2 (en) * 2014-12-18 2020-05-28 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
US10500318B1 (en) 2018-07-03 2019-12-10 Temple Therapeutics BV Dosing regimens for treating hypoxia-associated tissue damage
MX2021010599A (es) 2019-03-05 2021-12-10 Aerie Pharmaceuticals Inc Composiciones farmaceuticas para el tratamiento de enfermedades o trastornos oculares.
AU2022271004A1 (en) 2021-05-07 2023-11-16 Temple Therapeutics BV Methods of treating fibrosis and hypoxia-associated damage to peripheral nerves
WO2025163204A1 (en) 2024-02-01 2025-08-07 Temple Therapeutics BV Glutamine source for use in methods and compositions for reducing or preventing synovial joint adhesions or fibrosis

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008157254A2 (en) * 2007-06-20 2008-12-24 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
CA2419429C (en) * 2000-08-30 2010-07-27 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
CN103619910A (zh) * 2011-06-23 2014-03-05 帝斯曼知识产权资产管理有限公司 用于药物递送的新颖的聚酯酰胺共聚物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550730A (en) 1981-12-07 1985-11-05 Ethicon, Inc. Flexible monofilament surgical sutures comprising poly(polymethylene terephthalate, isophthalate or cyclohexane-1,4-dicarboxylate-co-dimerate)
EP0926184A1 (en) 1997-12-25 1999-06-30 Mitsui Chemicals, Inc. Process for production of polyamino acid derivative
EP1091761A1 (en) 1998-06-30 2001-04-18 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US7304122B2 (en) 2001-08-30 2007-12-04 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
CA2513443A1 (en) 2003-02-26 2004-09-10 Medivas, Llc Bioactive stents and methods for use thereof
JP2005139139A (ja) 2003-11-07 2005-06-02 Idemitsu Technofine Co Ltd 化粧料組成物
AU2005244848A1 (en) 2004-05-12 2005-12-01 Medivas, Llc Wound healing polymer compositions and methods for use thereof
US20050271700A1 (en) 2004-06-03 2005-12-08 Desnoyer Jessica R Poly(ester amide) coating composition for implantable devices
US20060009498A1 (en) 2004-07-12 2006-01-12 Allergan, Inc. Ophthalmic compositions and methods for treating ophthalmic conditions
US7390497B2 (en) 2004-10-29 2008-06-24 Advanced Cardiovascular Systems, Inc. Poly(ester amide) filler blends for modulation of coating properties
US20060159918A1 (en) 2004-12-22 2006-07-20 Fiber Innovation Technology, Inc. Biodegradable fibers exhibiting storage-stable tenacity
CN100551950C (zh) 2005-03-21 2009-10-21 中国科学院成都有机化学有限公司 一种可降解聚酯酰胺共聚物的制备方法
JP5178520B2 (ja) 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
CA2670355A1 (en) 2005-11-21 2008-04-24 Medivas, Llc Polymer particles for delivery of macromolecules and methods of use
US8974815B2 (en) 2005-12-16 2015-03-10 Cornell University Fibrous membrane for biomedical application based on poly(ester-amide)s
TWI376239B (en) 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
EP2019645A4 (en) 2006-05-02 2013-03-06 Medivas Llc RELEASE OF OPHTHALMOLOGICAL ACTIVITIES OUTSIDE OR WITHIN THE EYE
EP2021141A4 (en) 2006-05-09 2013-07-03 Medivas Llc BIODEGRADABLE WATER SOLUBLE POLYMERS
US8936780B2 (en) 2006-08-30 2015-01-20 Advanced Cardiovascular Systems, Inc. Stimuli responsive polyester amide particles
WO2008029917A1 (en) 2006-09-08 2008-03-13 Nikon Corporation Mask, exposure apparatus and device manufacturing method
US7649022B2 (en) 2007-03-30 2010-01-19 Medivas, Llc Bioabsorbable elastomeric polymer networks, cross-linkers and methods of use
EP2170419A1 (en) 2007-07-18 2010-04-07 Board Of Trustees Of The University Of Illinois Temporal release of growth factors from 3d micro rod scaffolds for tissue regeneration
CA2774036C (en) 2009-10-16 2018-04-03 Dsm Ip Assets B.V. Coatings comprising bis-(alpha-amino-diol-diester) containing polyesteramide
US20130142858A1 (en) 2010-05-17 2013-06-06 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
US20140179802A1 (en) 2011-05-02 2014-06-26 Dsm Ip Assets B.V. Fiber comprising a biodegradable polymer
EP2704748B1 (en) 2011-05-02 2018-08-15 DSM IP Assets B.V. Bis-(alpha-amino-diol-diester) containing polyesteramide for ophtamology
WO2013087903A1 (en) 2011-12-16 2013-06-20 Dsm Ip Assets B.V. Process for the manufacturing of a drug delivery system based on a polymer comprising a dispersed bioactive agent
WO2014053542A1 (en) 2012-10-02 2014-04-10 Dsm Ip Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
EP2911647B1 (en) 2012-10-23 2018-03-07 DSM IP Assets B.V. Process for the manufacturing of a multilayer drug delivery construct
US10538864B2 (en) 2012-10-24 2020-01-21 Dsm Ip Assets, B.V. Fibers comprising polyesteramide copolymers for drug delivery
WO2014096339A1 (en) 2012-12-20 2014-06-26 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2419429C (en) * 2000-08-30 2010-07-27 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
WO2008157254A2 (en) * 2007-06-20 2008-12-24 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
CN103619910A (zh) * 2011-06-23 2014-03-05 帝斯曼知识产权资产管理有限公司 用于药物递送的新颖的聚酯酰胺共聚物
CN103748139A (zh) * 2011-06-23 2014-04-23 帝斯曼知识产权资产管理有限公司 用于递送生物活性剂的包含生物可降解的聚酯酰胺共聚物的微米颗粒或纳米颗粒

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Publication number Publication date
US20150216987A1 (en) 2015-08-06
WO2014053542A1 (en) 2014-04-10
JP6330815B2 (ja) 2018-05-30
CA2881729C (en) 2021-05-04
JP2015534557A (ja) 2015-12-03
CA2881729A1 (en) 2014-04-10
IN2015DN01153A (enExample) 2015-06-26
CN104717962A (zh) 2015-06-17
EP2903592B1 (en) 2019-01-23
EP2903592A1 (en) 2015-08-12
US9789189B2 (en) 2017-10-17

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