CA2881729C - Drug delivery composition comprising proteins and biodegradable polyesteramides - Google Patents

Drug delivery composition comprising proteins and biodegradable polyesteramides Download PDF

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Publication number
CA2881729C
CA2881729C CA2881729A CA2881729A CA2881729C CA 2881729 C CA2881729 C CA 2881729C CA 2881729 A CA2881729 A CA 2881729A CA 2881729 A CA2881729 A CA 2881729A CA 2881729 C CA2881729 C CA 2881729C
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CA
Canada
Prior art keywords
composition according
release
protein
drug delivery
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2881729A
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English (en)
French (fr)
Other versions
CA2881729A1 (en
Inventor
Jens Christoph Thies
George Mihov
Guy Draaisma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CA2881729A1 publication Critical patent/CA2881729A1/en
Application granted granted Critical
Publication of CA2881729C publication Critical patent/CA2881729C/en
Active legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2881729A 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides Active CA2881729C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12186915 2012-10-02
EP12186915.0 2012-10-02
EP13173634.0 2013-06-25
EP13173634 2013-06-25
PCT/EP2013/070543 WO2014053542A1 (en) 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides

Publications (2)

Publication Number Publication Date
CA2881729A1 CA2881729A1 (en) 2014-04-10
CA2881729C true CA2881729C (en) 2021-05-04

Family

ID=49301494

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2881729A Active CA2881729C (en) 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides

Country Status (7)

Country Link
US (1) US9789189B2 (enExample)
EP (1) EP2903592B1 (enExample)
JP (1) JP6330815B2 (enExample)
CN (1) CN104717962B (enExample)
CA (1) CA2881729C (enExample)
IN (1) IN2015DN01153A (enExample)
WO (1) WO2014053542A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
EP4406558A3 (en) 2011-06-23 2024-10-23 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
WO2014053542A1 (en) 2012-10-02 2014-04-10 Dsm Ip Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
CA2892523A1 (en) * 2012-12-20 2014-06-26 George Mihov Coating comprising polyesteramide copolymers for drug delivery
US10434071B2 (en) 2014-12-18 2019-10-08 Dsm Ip Assets, B.V. Drug delivery system for delivery of acid sensitivity drugs
US10500318B1 (en) 2018-07-03 2019-12-10 Temple Therapeutics BV Dosing regimens for treating hypoxia-associated tissue damage
MX2021010599A (es) 2019-03-05 2021-12-10 Aerie Pharmaceuticals Inc Composiciones farmaceuticas para el tratamiento de enfermedades o trastornos oculares.
WO2021094468A1 (en) 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures
JP2024521037A (ja) 2021-05-07 2024-05-28 テンプル セラピューティクス ベスローテン フェンノートシャップ 末梢神経の線維症及び低酸素関連損傷を処置する方法
WO2025163204A1 (en) 2024-02-01 2025-08-07 Temple Therapeutics BV Glutamine source for use in methods and compositions for reducing or preventing synovial joint adhesions or fibrosis

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US7304122B2 (en) 2001-08-30 2007-12-04 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
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EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
JP5178520B2 (ja) 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
JP2009518289A (ja) * 2005-11-21 2009-05-07 メディバス エルエルシー 高分子の送達用ポリマー粒子および使用方法
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EP4406558A3 (en) 2011-06-23 2024-10-23 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
WO2013087903A1 (en) 2011-12-16 2013-06-20 Dsm Ip Assets B.V. Process for the manufacturing of a drug delivery system based on a polymer comprising a dispersed bioactive agent
WO2014053542A1 (en) 2012-10-02 2014-04-10 Dsm Ip Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
US20150246001A1 (en) 2012-10-23 2015-09-03 Dsm Ip Assets B.V. Process for the manufacturing of a multilayer drug delivery construct
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CA2892523A1 (en) 2012-12-20 2014-06-26 George Mihov Coating comprising polyesteramide copolymers for drug delivery

Also Published As

Publication number Publication date
JP6330815B2 (ja) 2018-05-30
JP2015534557A (ja) 2015-12-03
WO2014053542A1 (en) 2014-04-10
CN104717962B (zh) 2017-07-21
CA2881729A1 (en) 2014-04-10
IN2015DN01153A (enExample) 2015-06-26
CN104717962A (zh) 2015-06-17
US20150216987A1 (en) 2015-08-06
US9789189B2 (en) 2017-10-17
EP2903592B1 (en) 2019-01-23
EP2903592A1 (en) 2015-08-12

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