JP6330815B2 - タンパク質および生分解性ポリエステルアミドを含む薬物送達組成物 - Google Patents

タンパク質および生分解性ポリエステルアミドを含む薬物送達組成物 Download PDF

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JP6330815B2
JP6330815B2 JP2015533638A JP2015533638A JP6330815B2 JP 6330815 B2 JP6330815 B2 JP 6330815B2 JP 2015533638 A JP2015533638 A JP 2015533638A JP 2015533638 A JP2015533638 A JP 2015533638A JP 6330815 B2 JP6330815 B2 JP 6330815B2
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drug delivery
protein
polymer
delivery composition
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JP2015534557A (ja
Inventor
イェンス， クリストフ シエス，
イェンス， クリストフ シエス，
ジョージ ミホフ，
ジョージ ミホフ，
ガイ ドラーイスマ，
ガイ ドラーイスマ，
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DSM IP Assets BV
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DSM IP Assets BV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2015533638A 2012-10-02 2013-10-02 タンパク質および生分解性ポリエステルアミドを含む薬物送達組成物 Active JP6330815B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12186915 2012-10-02
EP12186915.0 2012-10-02
EP13173634 2013-06-25
EP13173634.0 2013-06-25
PCT/EP2013/070543 WO2014053542A1 (en) 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides

Publications (2)

Publication Number Publication Date
JP2015534557A JP2015534557A (ja) 2015-12-03
JP6330815B2 true JP6330815B2 (ja) 2018-05-30

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JP2015533638A Active JP6330815B2 (ja) 2012-10-02 2013-10-02 タンパク質および生分解性ポリエステルアミドを含む薬物送達組成物

Country Status (7)

Country Link
US (1) US9789189B2 (enExample)
EP (1) EP2903592B1 (enExample)
JP (1) JP6330815B2 (enExample)
CN (1) CN104717962B (enExample)
CA (1) CA2881729C (enExample)
IN (1) IN2015DN01153A (enExample)
WO (1) WO2014053542A1 (enExample)

Families Citing this family (9)

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US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CA2839526A1 (en) 2011-06-23 2012-12-27 Dsm Ip Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
EP2903592B1 (en) 2012-10-02 2019-01-23 DSM IP Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
US20150328374A1 (en) * 2012-12-20 2015-11-19 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery
EP3233067B1 (en) * 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
US10500318B1 (en) 2018-07-03 2019-12-10 Temple Therapeutics BV Dosing regimens for treating hypoxia-associated tissue damage
JP7570342B2 (ja) 2019-03-05 2024-10-21 アエリエ ファーマシューティカルズ インコーポレイテッド 眼の疾患又は障害を治療するための医薬組成物
JP2024521037A (ja) 2021-05-07 2024-05-28 テンプル セラピューティクス ベスローテン フェンノートシャップ 末梢神経の線維症及び低酸素関連損傷を処置する方法
WO2025163204A1 (en) 2024-02-01 2025-08-07 Temple Therapeutics BV Glutamine source for use in methods and compositions for reducing or preventing synovial joint adhesions or fibrosis

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EP0926184A1 (en) 1997-12-25 1999-06-30 Mitsui Chemicals, Inc. Process for production of polyamino acid derivative
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EP2790667B1 (en) 2011-12-16 2017-03-22 DSM IP Assets B.V. Process for the manufacturing of a drug delivery system based on a polymer comprising a dispersed bioactive agent
EP2903592B1 (en) 2012-10-02 2019-01-23 DSM IP Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
EP2911647B1 (en) 2012-10-23 2018-03-07 DSM IP Assets B.V. Process for the manufacturing of a multilayer drug delivery construct
US10538864B2 (en) 2012-10-24 2020-01-21 Dsm Ip Assets, B.V. Fibers comprising polyesteramide copolymers for drug delivery
US20150328374A1 (en) 2012-12-20 2015-11-19 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery

Also Published As

Publication number Publication date
EP2903592B1 (en) 2019-01-23
CA2881729A1 (en) 2014-04-10
CN104717962B (zh) 2017-07-21
IN2015DN01153A (enExample) 2015-06-26
JP2015534557A (ja) 2015-12-03
CN104717962A (zh) 2015-06-17
US20150216987A1 (en) 2015-08-06
US9789189B2 (en) 2017-10-17
EP2903592A1 (en) 2015-08-12
WO2014053542A1 (en) 2014-04-10
CA2881729C (en) 2021-05-04

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