CN104706978A

CN104706978A - Medicine for treating gingivitis caused by kidney yin deficiency and preparation method of medicine

Info

Publication number: CN104706978A
Application number: CN201510167864.7A
Authority: CN
Inventors: 陈安威; 刘少华; 万凤丽; 王桦; 郭延举
Original assignee: Shandong Three Lives New Material Science And Technology Ltd
Current assignee: Shandong Three Lives New Material Science And Technology Ltd
Priority date: 2015-04-10
Filing date: 2015-04-10
Publication date: 2015-06-17

Abstract

The invention discloses a medicine for treating gingivitis caused by kidney yin deficiency and a preparation method of the medicine. The medicine is prepared from the following medicinal materials: radix rehmanniae praeparata, stellaria neglecta weihe, polygonum multiflorum, manyflower supplejack stem and leaf, fructus broussonetiae, turbinate aster, dendrobe, polygonum polystachyum, polygonatum kingianum, freshwater snail's operculum, wolfberry fruit, eclipta, loropetalum chinense, glossy privet fruit, agilawood, mulberry, radix ophiopogonis, angelica sinensis, buckwheat straw, codonopsis pilosula, dwarf lilyturf, human placenta, semen cuscutae, physalis angulata, eucommia ulmoides, pandanus tectorius soland, platycladi seed, metaplexis fruit, ganoderma lucidum, chinese elder, acorus tatarinowii, pennycress seed, manyprickle acanthopanax root and deer's thyroid gland. The medicine has the beneficial effects that the medicine has the effect of nourishing kidney yin and is mainly used for treating gingivitis caused by kidney yin deficiency; by virtue of the theory of the traditional Chinese medicine, on the basis of the integer concept, treatment based on syndrome differentiation is carried out by regulating dynamic balance of qi and blood, yin and yang and integral organs of the organism and internal environments of the integral organs; multi-target specific treatment is carried out; and the medicine has the advantages of being fast in acting, high in effective rate, accurate in curative effect, short in treatment course, free of a toxic or side effect and low in proce.

Description

A kind ofly treat medicine of kidney-yin deficiency type gingivitis and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind ofly treat medicine of kidney-yin deficiency type gingivitis and preparation method thereof.

Background technology

Gingivitis refers to the Acute and chronic inflammation occurring in gingiva tissue.Gingiva (gingiva) refers to and is covered in oral mucous epithelia around alveolar process surface and neck portion and the connective tissue of below thereof.Dental plaque is the initiation factor of gingivitis, and gingivitis common manifestation is gingival hemorrhage, and red and swollen, distending pain, likely causes periodontitis to Deep Development.Stimulated by bacteriological infection, foreign object and food impaction etc. all can cause gingivitis, and generally modal is based on bacteriological infection.

The cause of disease of gingivitis: the Etiological of gingivitis is poor oral hygiene, causes dental plaque, dental calculus and soft dirt facing deposition near gum edge, thus brings out gingivitis.If treat not in time, gingivitis can develop into periodontitis gradually, finally causes full mouth to open odontoseisis and forfeiture.

The clinical manifestation of gingivitis: 1, gingival hemorrhage: how the main subjective symptoms being often gingivitis patients, occur when brushing teeth or sting hard object, even also can have hematostaxis.2, gingiva color: normal gingiva pinkiness, dissociate when suffering from marginal ginhivitis gum and gum nipple become dark red or kermesinus, and this is caused by the congestion of blood vessel in gingival connective tissue, hypertrophy.3, gingival contour: normal gingiva should be poor and is close to facing, and when suffering from gingivitis, due to tissue edema, make gum edge thickening, be no longer close to facing, gum nipple becomes the blunt hypertrophy of circle, is no longer close to facing.With inflammation and ooze out for major lesions person, the soft hypertrophy of gingiva, surface-brightening, gum edge sometimes erosion oozes out; In the case based on fibroproliferation, the tough and tensile hypertrophy of gingiva, sometimes can be nodositas and cover part facing.4, gingiva quality: because inflammatory infiltration in connective tissue and collagen fiber disappear, make the gingiva of original quality densification become soft fragility, lack flexibility.During some chronic inflammatory disease, gingival surface epithelial proliferation is thickening, collagen fiber hyperplasia, make gingival surface it seems hard plumpness, but periodontal pocket inwall has inflammation, visit examined hemorrhage.5, depth of pocket: when periodontal tissue is healthy, depth of pocket is generally no more than 2-3mm, and when gingiva has inflammatory swelling or hypertrophy, gingival sulcus can deepen to reach more than 3mm, forms false periodontal pocket.6, spy is examined hemorrhage: healthy gingiva does not all cause bleeding when brushing teeth or detect gingival sulcus.Touch hemorrhage when suffering from gingivitis, spy is examined also hemorrhage.Visit and examine the rear hemorrhage important objective index being diagnosis gingiva and having NIP.7, level in gingival sulcus fluid increases: when gingiva has an inflammation, level in gingival sulcus fluid is oozed out and increased, and the also showed increased of leukocyte wherein, some patient also can have gingival sulcus pyorrhea.Therefore measure gingival crevicular fluid and can be used as the index judging degree of inflammation.8, some patient feels the discomforts such as itch in gingiva local, swollen occasionally, and has halitosis etc.

Gingivitis comprises following a few class: 1, chronic gingivitis: be modal a kind of form, prevalence is high, and almost everyone certain period in all one's life all can occurrence degree and scope chronic gingivitis not etc.The dental plaque near gum edge, facing piled up is the initiation factor of chronic gingivitis, and the factor such as other are as crowded in tartar, food impaction, ill fitting prosthesis, transposition of teeth, mouth breathing all can promote gathering of bacterial plaque, causes or increase the weight of the inflammation of gingiva.2, pubertal gingivitis: be one of gingivitis being subject to endocrinologic effects, men and women all can be ill, but female patient is slightly more than male.Bacterial plaque is still the Etiological of pubertal gingivitis, the crowd of this age bracket, due to newborn permanent teeth substitute, tooth arrangement is uneven, cause tooth not easy to clean, in addition the patient of this age bracket not easily keeps good oral sanitary habit, easily causes the delay of bacterial plaque, causes gingivitis.The change of sex hormone level in children in adolescence's body, be the systemic factor of pubertal gingivitis, gingiva is the target tissue of gonadal hormone, due to endocrine change, gingiva tissue strengthens the reactivity of the local excitation things such as bacterial plaque, produces obvious inflammation or original chronic gingivitis is increased the weight of.3, pregnancy gingivitis: similar with pubertal gingivitis is also the change due to systemic hormone levels, and original gingiva chronic inflammatory disease is increased the weight of, and makes swelling and aching of gum or form epulis sample to change, and a point puerperium disease damage can alleviate voluntarily or disappear.4, acute papillary gingivitis: disease damage is confined to indivedual gingival papilla, stimulation such as food impaction, unsuitable use toothpick, mistake that gingival papilla is subject to machinery or chemistry are stabbed as hard as sharp food, the edge etc. of ill fitting prosthesis, produce acute inflammation, show as the rubescent swelling of indivedual gum nipples, there is idiopathic distending pain and significantly visit tenderness, even having caloric stimulation pain.5, trench mouth: occurrence cause is caused by fusiform bacilarmature and spirillum amount reproduction infect in oral cavity.Generally passive protective physical fitness reduction, malnutrition, overtired time easily occur.Onset is comparatively anxious, from the beginning of two, three days in, red swelling of gingiva, hemorrhage, gingival edge rots.Rotten to the corn place has canescence pseudomembrane to cover, and easily wipes away.Gum nipple is cut shape as cutter and is disappeared, and oral cavity foul smelling, salivation increases, and flows out during sleep from bicker, often will rest the head on contaminated.Fester as spread to places such as cheek, palate, lip, tongues, then become necrotic stomatitis.If process not in time, can threat to life.As to pharyngeal development, cause pharyngeal pain, feed is swallowed all very painful.Submandibular lymph nodes enlargement, general medical condition chump can concurrent high heat.

The traditional Chinese medical science analyzes the cause of disease of gingivitis, by kidney is led, and deficiency of kidney essence insufficiency of blood, tooth loses and moistens foster, causes sclerotin flaccidity soft, holds concurrently with hyperactivity of fire caused by deficiency of YIN, and hyperactivity of deficient fire is in gum meat, and then tooth shakes for a long time, root reveals; Or due to ferritic weakness, or prolonged illness consumption hinders healthy energy, insufficiency of vital energy and blood, gingiva loses the pathogenic factor in nourishing and takes advantage of a weak point, so that the atrophy of gum meat, escape of blood from meridians, gingiva bleeding gingival hemorrhage, therefore become this sick, therefore distinguish that its clinical syndrome is divided into: 1. excessiveness of stomach-fire type: gingiva is had a pain, hemorrhage, implication is hot smelly, thirst and desire for cold drink, is convenient to greatly knot.Red swelling of gingiva pain, overflows pus and blood.Red tongue, yellow fur, rapid pulse.2, kidney-yin deficiency type: gingival atrophy, tooth root loosening, the micro-redness of gingival mucosa.Or have dizziness, tinnitus, soreness of the waist and knees.Red tongue with a little fluid, thin fur, thready and rapid pulse.3, deficiency of qi and blood type: gingival atrophy, in vain light, root of the tooth a surname dew, odontoseisis, masticatory atonia, has oozing of blood during gingiva.Pallor or sallow, lassitude. light red tongue, tongue is white, weak pulse.

At present, western medical treatment gingivitis application antibiotic, vitamin A, vitamin C, vitamin D; Apply l% iodine glycerol after hydrogenperoxide steam generator with 3% or normal saline flushing, also can gargle with 1:5000 potassium permanganate solution or Dobell's solution, also alternative use rinsing the mouth medicine, as compound chlorhexidine gargle, refined scholar's collutorium etc.; The feasible gingivectomy of the obvious person of gingival hyperplasia.

But western medical treatment gingivitis toxic and side effects is more, and the course for the treatment of is longer, route of administration is inconvenient, and clinical efficacy is not satisfactory, brings inconvenience to the life of patient.

Summary of the invention

Technical problem to be solved by this invention is, there is provided a kind of and treat medicine of kidney-yin deficiency type gingivitis and preparation method thereof, the present invention has effect of nourishing kidney yin, cure mainly kidney-yin deficiency type gingivitis, utilize Traditional Chinese medical theory, on the basis of organic conception, by regulate the negative and positive of qi and blood of animal economy, each internal organs and the dynamic equilibrium of environment, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Mutiple Targets, immunotherapy targeted autoantibody, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of kidney-yin deficiency type gingivitis, wherein, following raw medicinal material is comprised: Radix Rehmanniae Preparata, match Herba stellariae mediae, Radix Polygoni Multiflori, Ramulus et folium berchemiae floribundae, Fructus Broussonetiae, Herba Asteris Turbinati, Herba Dendrobii, Herba Polygoni polystachyi, Rhizoma Polygonati, river-snail operculum, Fructus Lycii, Herba Ecliptae, Flos Loropetali (Herba Loropetali), Fructus Ligustri Lucidi, Lignum Aquilariae Resinatum, Fructus Mori, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis et Folium Fagopyri esculenti, Radix Codonopsis, basket for holding earth grass, Placenta Hominis, Semen Cuscutae, Herba Physalis pubescentis, the Cortex Eucommiae, Radix Pandani tectorii, Semen Platycladi, Fructus metaplexis, Ganoderma, Herba sambuci chinensis, Rhizoma Acori Graminei, Semen thlaspis, Radix Et Caulis Acanthopanacis Senticosi and Thyreoid Cervi.

Wherein, in described medicine, the parts by weight of each raw medicinal material can preferably than being Radix Rehmanniae Preparata 10 ~ 35 parts, match Herba stellariae mediae 15 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 32 parts, Ramulus et folium berchemiae floribundae 10 ~ 35 parts, Fructus Broussonetiae 12 ~ 24 parts, Herba Asteris Turbinati 12 ~ 31 parts, Herba Dendrobii 11 ~ 28 parts, Herba Polygoni polystachyi 13 ~ 33 parts, Rhizoma Polygonati 14 ~ 36 parts, river-snail operculum 12 ~ 24 parts, Fructus Lycii 11 ~ 23 parts, Herba Ecliptae 13 ~ 26 parts, Flos Loropetali (Herba Loropetali) 12 ~ 28 parts, Fructus Ligustri Lucidi 13 ~ 32 parts, Lignum Aquilariae Resinatum 10 ~ 23 parts, 10 ~ 27 parts, Fructus Mori, Radix Ophiopogonis 12 ~ 31 parts, Radix Angelicae Sinensis 13 ~ 29 parts, Caulis et Folium Fagopyri esculenti 14 ~ 34 parts, Radix Codonopsis 12 ~ 32 parts, basket for holding earth grass 15 ~ 38 parts, Placenta Hominis 11 ~ 26 parts, Semen Cuscutae 13 ~ 37 parts, Herba Physalis pubescentis 13 ~ 37 parts, the Cortex Eucommiae 16 ~ 31 parts, Radix Pandani tectorii 10 ~ 25 parts, Semen Platycladi 13 ~ 28 parts, Fructus metaplexis 11 ~ 31 parts, Ganoderma 15 ~ 38 parts, Herba sambuci chinensis 3 ~ 5 parts, Rhizoma Acori Graminei 12 ~ 36 parts, Semen thlaspis 14 ~ 32 parts, Radix Et Caulis Acanthopanacis Senticosi 16 ~ 38 parts and Thyreoid Cervi 10 ~ 25 parts.

Wherein, in described medicine, the parts by weight of each raw medicinal material can also preferably than being Radix Rehmanniae Preparata 12 ~ 33 parts, match Herba stellariae mediae 16 ~ 23 parts, Radix Polygoni Multiflori 12 ~ 30 parts, Ramulus et folium berchemiae floribundae 12 ~ 32 parts, Fructus Broussonetiae 14 ~ 23 parts, Herba Asteris Turbinati 15 ~ 30 parts, Herba Dendrobii 13 ~ 25 parts, Herba Polygoni polystachyi 15 ~ 30 parts, Rhizoma Polygonati 15 ~ 34 parts, river-snail operculum 14 ~ 22 parts, Fructus Lycii 14 ~ 22 parts, Herba Ecliptae 14 ~ 25 parts, Flos Loropetali (Herba Loropetali) 14 ~ 26 parts, Fructus Ligustri Lucidi 15 ~ 30 parts, Lignum Aquilariae Resinatum 12 ~ 23 parts, 13 ~ 26 parts, Fructus Mori, Radix Ophiopogonis 14 ~ 30 parts, Radix Angelicae Sinensis 14 ~ 27 parts, Caulis et Folium Fagopyri esculenti 15 ~ 33 parts, Radix Codonopsis 14 ~ 31 parts, basket for holding earth grass 16 ~ 36 parts, Placenta Hominis 12 ~ 25 parts, Semen Cuscutae 14 ~ 33 parts, Herba Physalis pubescentis 15 ~ 35 parts, the Cortex Eucommiae 17 ~ 30 parts, Radix Pandani tectorii 13 ~ 23 parts, Semen Platycladi 15 ~ 26 parts, Fructus metaplexis 13 ~ 30 parts, Ganoderma 16 ~ 36 parts, Herba sambuci chinensis 3 ~ 5 parts, Rhizoma Acori Graminei 14 ~ 35 parts, Semen thlaspis 15 ~ 31 parts, Radix Et Caulis Acanthopanacis Senticosi 17 ~ 36 parts and Thyreoid Cervi 12 ~ 24 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Rehmanniae Preparata 12 parts, match Herba stellariae mediae 23 parts, Radix Polygoni Multiflori 30 parts, Ramulus et folium berchemiae floribundae 28 parts, Fructus Broussonetiae 22 parts, Herba Asteris Turbinati 30 parts, Herba Dendrobii 25 parts, Herba Polygoni polystachyi 30 parts, Rhizoma Polygonati 26 parts, river-snail operculum 20 parts, Fructus Lycii 19 parts, Herba Ecliptae 22 parts, Flos Loropetali (Herba Loropetali) 25 parts, Fructus Ligustri Lucidi 18 parts, Lignum Aquilariae Resinatum 20 parts, 26 parts, Fructus Mori, Radix Ophiopogonis 30 parts, Radix Angelicae Sinensis 17 parts, Caulis et Folium Fagopyri esculenti 31 parts, Radix Codonopsis 30 parts, basket for holding earth grass 34 parts, Placenta Hominis 23 parts, Semen Cuscutae 30 parts, Herba Physalis pubescentis 34 parts, the Cortex Eucommiae 23 parts, Radix Pandani tectorii 15 parts, Semen Platycladi 24 parts, Fructus metaplexis 27 parts, Ganoderma 32 parts, Herba sambuci chinensis 3 parts, Rhizoma Acori Graminei 33 parts, Semen thlaspis 25 parts, Radix Et Caulis Acanthopanacis Senticosi 35 parts and Thyreoid Cervi 20 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Rehmanniae Preparata 30 parts, match Herba stellariae mediae 20 parts, Radix Polygoni Multiflori 15 parts, Ramulus et folium berchemiae floribundae 24 parts, Fructus Broussonetiae 15 parts, Herba Asteris Turbinati 28 parts, Herba Dendrobii 22 parts, Herba Polygoni polystachyi 18 parts, Rhizoma Polygonati 32 parts, river-snail operculum 20 parts, Fructus Lycii 17 parts, Herba Ecliptae 22 parts, Flos Loropetali (Herba Loropetali) 25 parts, Fructus Ligustri Lucidi 30 parts, Lignum Aquilariae Resinatum 22 parts, 25 parts, Fructus Mori, Radix Ophiopogonis 28 parts, Radix Angelicae Sinensis 24 parts, Caulis et Folium Fagopyri esculenti 31 parts, Radix Codonopsis 26 parts, basket for holding earth grass 33 parts, Placenta Hominis 23 parts, Semen Cuscutae 30 parts, Herba Physalis pubescentis 31 parts, the Cortex Eucommiae 27 parts, Radix Pandani tectorii 20 parts, Semen Platycladi 23 parts, Fructus metaplexis 30 parts, Ganoderma 34 parts, Herba sambuci chinensis 4 parts, Rhizoma Acori Graminei 33 parts, Semen thlaspis 25 parts, Radix Et Caulis Acanthopanacis Senticosi 34 parts and Thyreoid Cervi 15 parts.

Wherein, in described medicine, the parts by weight of each raw medicinal material again can preferably than being Radix Rehmanniae Preparata 31 parts, match Herba stellariae mediae 22 parts, Radix Polygoni Multiflori 16 parts, Ramulus et folium berchemiae floribundae 18 parts, Fructus Broussonetiae 20 parts, Herba Asteris Turbinati 27 parts, Herba Dendrobii 25 parts, Herba Polygoni polystachyi 30 parts, Rhizoma Polygonati 32 parts, river-snail operculum 21 parts, Fructus Lycii 16 parts, Herba Ecliptae 24 parts, Flos Loropetali (Herba Loropetali) 15 parts, Fructus Ligustri Lucidi 30 parts, Lignum Aquilariae Resinatum 19 parts, 22 parts, Fructus Mori, Radix Ophiopogonis 27 parts, Radix Angelicae Sinensis 21 parts, Caulis et Folium Fagopyri esculenti 31 parts, Radix Codonopsis 28 parts, basket for holding earth grass 34 parts, Placenta Hominis 22 parts, Semen Cuscutae 31 parts, Herba Physalis pubescentis 32 parts, the Cortex Eucommiae 26 parts, Radix Pandani tectorii 16 parts, Semen Platycladi 24 parts, Fructus metaplexis 30 parts, Ganoderma 35 parts, Herba sambuci chinensis 3 parts, Rhizoma Acori Graminei 34 parts, Semen thlaspis 29 parts, Radix Et Caulis Acanthopanacis Senticosi 34 parts and Thyreoid Cervi 22 parts.

Wherein, when the dosage form of described medicine is collutory, its preparation method comprises the following steps: when the dosage form of described medicine is collutory, its preparation method comprises the following steps:

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, adds the deionized water relative to mixed powder quality 2 ~ 3 times, decocts 2 ~ 4 hours, filter in the mixed powder that second step obtains, and obtains medicine juice and is collutory.

Wherein, when the dosage form of described medicine is spray, its preparation method comprises the following steps:

Herba sambuci chinensis, Rhizoma Acori Graminei, Semen thlaspis, Radix Et Caulis Acanthopanacis Senticosi and Thyreoid Cervi mix by first step, add relative to mixture 3 times ~ 5 times amount determining alcohol be 55% ~ 65% alcohol reflux 2 times ~ 4 times, each 2 hours ~ 3 hours, filter, filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.30 ~ 1.32, for subsequent use;

Second step, Radix Rehmanniae Preparata, match Herba stellariae mediae, Radix Polygoni Multiflori, Ramulus et folium berchemiae floribundae, Fructus Broussonetiae, Herba Asteris Turbinati, Herba Dendrobii, Herba Polygoni polystachyi, Rhizoma Polygonati, river-snail operculum, Fructus Lycii, Herba Ecliptae, Flos Loropetali (Herba Loropetali), Fructus Ligustri Lucidi, Lignum Aquilariae Resinatum, Fructus Mori, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis et Folium Fagopyri esculenti, Radix Codonopsis, basket for holding earth grass, Placenta Hominis, Semen Cuscutae, Herba Physalis pubescentis, the Cortex Eucommiae, Radix Pandani tectorii, Semen Platycladi, Fructus metaplexis and Ganoderma are mixed in proportion, add relative to mixture 3 ~ 5 times of water gagings, boil 2 ~ 4 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27 ~ 1.29;

3rd step, the described mastic mixing that the first step, second step are obtained, 55 DEG C ~ 65 DEG C reduced vacuum dryings, get dry extract powder; 4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 30 ~ 40 hours;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.1 ~ 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.001 ~ 0.002; The time of described heat treated is 20 ~ 40 minutes, and temperature is 100 DEG C ~ 110 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicament spraying agent finished product.

Wherein, when the dosage form of described medicine is buccal tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

The invention has the beneficial effects as follows: the present invention has effect of nourishing kidney yin, cure mainly kidney-yin deficiency type gingivitis, utilize Traditional Chinese medical theory, on the basis of organic conception, by regulate the negative and positive of qi and blood of animal economy, each internal organs and the dynamic equilibrium of environment, carry out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, Mutiple Targets, immunotherapy targeted autoantibody, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

The traditional Chinese medical science thinks that tooth is led by kidney, deficiency of kidney essence insufficiency of blood, and tooth loses and moistens foster, causes sclerotin flaccidity soft, holds concurrently with hyperactivity of fire caused by deficiency of YIN, hyperactivity of deficient fire in gum meat, for a long time then tooth shake, root dew; Or due to ferritic weakness, or prolonged illness consumption hinders healthy energy, insufficiency of vital energy and blood, and gingiva loses the pathogenic factor in nourishing and takes advantage of a weak point, so that the atrophy of gum meat, escape of blood from meridians, gingiva bleeding gingival hemorrhage, therefore becomes this sick.

Therefore, the invention provides a kind of medicine for the treatment of kidney-yin deficiency type gingivitis, take nourishing kidney yin as primary treatment principle, wherein, following raw medicinal material is comprised: Radix Rehmanniae Preparata, match Herba stellariae mediae, Radix Polygoni Multiflori, Ramulus et folium berchemiae floribundae, Fructus Broussonetiae, Herba Asteris Turbinati, Herba Dendrobii, Herba Polygoni polystachyi, Rhizoma Polygonati, river-snail operculum, Fructus Lycii, Herba Ecliptae, Flos Loropetali (Herba Loropetali), Fructus Ligustri Lucidi, Lignum Aquilariae Resinatum, Fructus Mori, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis et Folium Fagopyri esculenti, Radix Codonopsis, basket for holding earth grass, Placenta Hominis, Semen Cuscutae, Herba Physalis pubescentis, the Cortex Eucommiae, Radix Pandani tectorii, Semen Platycladi, Fructus metaplexis, Ganoderma, Herba sambuci chinensis, Rhizoma Acori Graminei, Semen thlaspis, Radix Et Caulis Acanthopanacis Senticosi and Thyreoid Cervi.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Rehmanniae Preparata: sweet in the mouth, slightly warm in nature, enters liver, kidney channel, Compendium of Material Medica: " fill out bone marrow, longue meat, promoting generation of vital essence and blood.Tonifying five ZANG-organs internal injury is not enough, and promoting blood circulation, sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments." there is YIN nourishing of enriching blood, beneficial essence fills out the effect of marrow, for blood deficiency and yellow complexion; Dizzy, cardiopalmus, insomnia, menoxenia, collapses more than; Hepatic and renal YIN deficiency, night sweat, sufficient knee joint pain, soreness of the waist and knees, Hiccough and deaf, the head is dim-sighted, and seminal emission sexual impotence, infertility, menoxenia, metrostaxis, early whitening of beard and hair, quenches one's thirst, the cards such as dyspnea with rapid and short breath of suffering from a deficiency of the kidney.

Radix Polygoni Multiflori: sweet in the mouth, micro-hardship, property is put down; GUIXIN, Liver Channel, have effect of energy tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral, cure mainly insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; The cards such as skin pruritus, Caulis Polygoni Multiflori can be invigorated blood circulation, stimulate the menstrual flow, the detumescence of blood vessel dilating, blood circulation promoting, stimulating milk secretion.Have promotion hemopoietic function, strengthen immunologic function, blood fat reducing and atherosclerosis, protect the liver, and Radix Polygoni Multiflori contains the effective ingredient such as chrysophanol, emodin, chrysophanic acid, physcione, fatty oil, starch, saccharide, rhaponticin, lecithin.

Fructus Broussonetiae: sweet, cold.Enter liver, spleen, kidney channel." Japan hanako materia medica ": " tonify deficiency labor, helps waist knee joint, beneficial color for strengthening bone and muscle, aid yang qi." " your name book on Chinese herbal medicine ": " strengthening bone and muscle, aid yang qi, tonify deficiency labor, help waist knee joint, beneficial color." the kidney invigorating liver heat removing, improving eyesight, diuresis.To swoon blurred vision, the raw nebula film of order, edema distension for soreness of the waist and knees, asthenia hectic fever due to YIN-deficiency, sand.

Herba Dendrobii: cold nature, sweet in the mouth, returns stomach, kidney channel, has reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat.Cure mainly cloudy impairment of body fluid to lose, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, the cards such as poor vision.Herba Dendrobii can significantly improve superoxides discrimination China enzyme (SOD) level, reduces lipid peroxide (LPO), regulates brain monoaminergic transmitters level, suppresses similar monoamine oxidase, MAO (MAO), play the effect of slow down aging.Herba Dendrobii contains lactone component, has the condensation of blood circulation promoting and blood stasis dispelling, blood vessel dilating and antiplatelet, and treatment embolic occlusion pulse tube is scorching, cerebral thrombosis, the effects such as arteriosclerotic obliteration.The luxuriant and rich with fragrance class extracted in Herba Dendrobii and bibenzyl material, have the effect of anti-pulmonary carcinoma, adenocarcinoma ovaries and promyelocitic leukemia.Herba Dendrobii has excitation to intestinal tube, and shrinkage amplitude can be made to increase.

Rhizoma Polygonati: sweet in the mouth, property is put down, and enters lung, spleen, kidney channel, there is enriching qi and yin, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, dry cough expectorant is few, polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, quenching one's thirst of yin asthenia generating intrinsic heat, the card such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

Fructus Lycii: sweet is flat.Enter liver, kidney, lung meridian." Treatise on Dietetic Therapy ": " hard muscle is always resistance to, and except wind, tonification muscles and bones, the beneficial people of energy, removes asthenia." control hepatic and renal YIN deficiency, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, impotence and seminal emission, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.

Herba Ecliptae: cool in nature, sweet in the mouth acid.Tang Materia Medica: " main dysentery.Acupuncture skin ulcer is sent out, and big vast blood can not the person of stopping apply it; Juice is coated with sends out an eyebrow, raw speed and numerous." " classifying herbal ": " hemostasis, the kidney invigorating, annealing, detumescence.Control pouring, collapse." there is effect of cooling blood for hemostasis, the kidney invigorating and essence nourishing, be usually used in treatment haematemesis, epistaxis, hematuria, have blood in stool, the disease such as dysentery, knife injury are hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, be slightly cold, enters liver, kidney channel, has strong liver kidney tonifying, the effect of clearing away heat to improve acuity of vision, is mainly used in treating hepatic and renal YIN deficiency, and the head loses foster dizzy tinnitus, the symptoms such as yin asthenia generating intrinsic heat.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, slowly must get effect.Compendium of Material Medica is recorded: " to insult winter verdant for this wood, has the behaviour that chastity is kept, therefore with Fructus Ligustri Lucidi shape it ... to put wax insect time near, therefore be commonly called as wax tree." Fructus Ligustri Lucidi can promote leukocyte, strengthens effect of immunologic function, has stronger inhibitory action to staphylococcus aureus, dysentery bacterium.Modern medicine study proves, Fructus Ligustri Lucidi includes ursolic acid, mannitol, glucose, fatty wet goods, has heart tonifying, diuresis and hepatoprotective effect, the leukopenia quantity caused because of chemotherapy can be made to raise, and have inhibitory action to staphylococcus aureus, escherichia coli.

Fructus Mori: bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.Supplement to the Herbal: " main abdominal pain due to acute vomiting and diarrhea is told down, and the eleventh month of the lunar calendar takes it with dense the boiling of dry person.Smooth file, takes as red sugar in large still, removes old wind and stagnated blood." " Japan hanako materia medica ": " sharp the five internal organs, get round by bribery, the therapeutic method to keep the adverse QI flowing downwards, decoction; Except wind pain is perspired, and flutter damage blood stasis, and Zheng Hou An; Scolopendra stings snakeworm, and salt Norway applies." Folium Mori energy dispelling wind and heat pathogens, heat clearing away of inducing sweat, YIN nourishing and the production of body fluid promoting; Fructus Mori energy nourishing YIN and benefiting blood, tonify deficiency is moisturized; The eliminating pathogen from the lung for relieving asthma of Cortex Mori energy, inducing diuresis to remove edema; Ramulus Mori energy dredge the meridian passage, eliminating impediment pain relieving; And the ash that mulberry burns till is Pulvis Lignum Mori, also can be used for the treatment of conjunctival congestion and swelling pain, optic atrohic blindness, body face edema, sitting and lying must not, the disease such as vitiligo, seborrheic dermatitis of the scalp, leprosy.Containing trypsininhibitory substance in Fructus Mori, cause the digestive enzyme in intestinal can not destroy C type and produce bacillus capsulatus B toxin, and causing bleeding property enteritis.Fructus Mori fatty acids, excessive eating can produce irritation to digestive tract.

Radix Angelicae Sinensis: sweet in the mouth, pungent, bitter, warm in nature, enters liver, the heart, spleen channel, " Treatise on Febrile Disease with Notes ": " the arteries and veins person house of blood, all blood all belongs to the heart, and all persons of promoting blood circulation must first reinforcing the heart benefit blood, therefore Zhang Zhongjing is controlled brothers and fainted cold, thready pulse being about to disappear person, by the hardship temperature of Radix Angelicae Sinensis to help painstaking effort." " book on Chinese herbal medicine is newly organized ": " Radix Angelicae Sinensis, sweet in the mouth is pungent, temperature, can rise and can fall, the YIN aspect of YANG, nontoxic.Though there is upper purgation to divide, enrich blood then one.Enter the heart, spleen, liver three are dirty.But its property is very dynamic, then QI invigorating in the Qi-tonifying drug entered, then enriches blood in the hematonic entered, without determining merit also." have to enrich blood and invigorate blood circulation, the effect of menstruction regulating and pain relieving, the relieving constipation of profit soup, for cards such as blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.1. oxygen lack resistant function; 2. conditioner body immunity function, there is antitumaous effect; 3. cosmetology effect; 4. to enrich blood the effect of invigorating blood circulation; 5. antibacterial, arteriosclerosis effect.Modern study shows, Radix Angelicae Sinensis has conditioner body immunity function, enriches blood and invigorate blood circulation, antibacterial effect of Denging.It can improve uterus blood circulation, alleviate pelvic congestion, relieving dysmenorrhea, in addition, Radix Angelicae Sinensis can the immunity of enhancing body.

Radix Codonopsis: property is put down, sweet in the mouth, micro-acid; Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.These product are clinical conventional Qi-tonifying drug, function invigorating the spleen to benefit the lung, and effect person of modern times joins and is more weak, is applicable to various deficiency of vital energy deficiency person.Contained saponin, inulin, Alkaloid, starch etc. have strong effect in various degree to human body multi viscera, can improve the adaptability of human body.

Placenta Hominis: sweet, salty, warm; Enter lung, the heart, kidney channel.Supplement to the Herbal: " main QI and blood weakness and emaciation, married woman strains, and it is black that skin is blackened in face, all diseases gradually thin worried person in abdomen." modern medicine study thinks, Placenta Hominis is containing protein, sugar, calcium, vitamin, immune factor, estrogen, gravidity assisting ketone, steroid hormone, promoting sexual gland hormone, thyroliberin etc., mammary gland can be promoted, uterus, vagina, the growth of testis, also facilitation is had to thyroid, clinically be used for the treatment of uterine hypoplasia, metratrophia, myometritis, functional menolipsis, metrorrhagia, milk deficiency etc., all there is significant curative effect, to pulmonary tuberculosis, bronchial asthma, anemias etc. also have good effect, grind oral or coloclysis into powder and can prevent measles or mitigation symptoms.Also certain curative effect is had to portal cirrhotic ascites and schistosomicide end-age cirrhosis ascites.

Semen Cuscutae: abnormal smells from the patient is pungent, sweet, flat, nontoxic." not Lu ": " support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence is from going out, and drown and have the heeltap, bitter taste is yearningly dry, and cold blood is long-pending." " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary." the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.

The Cortex Eucommiae: sweet in the mouth, micro-pungent, warm in nature, enters liver, kidney channel." beautiful Chinese catalpa medicine solution ": " liver and kidney tonifying, nourishing muscle and tendon bone go to joint to wet excessive.Control soreness of waist and knee joint, the contracture of lower limb foot." Shennong's Herbal: " main pain along the spinal column, invigorating middle warmer benefit vital essence, hard muscles and bones, Qiang Zhi, except wet, dribbling urination of itching under the moon." " property of medicine opinion ": " control the cold buttocks lumbago of kidney, waist disease people is empty and stiffness of the body is straight, and wind is also.Waist unfavorable adding and use it." Cortex Eucommiae has invigorating the liver and kidney, bone and muscle strengthening, rubbish in purged body; strengthen human body cell substance metabolism; prevent muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol; reduce body fat; recover blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic; stimulating central nervous system, improve leukocyte pharmacological action.The leaf of the Cortex Eucommiae and skin contain the nutritional labelings such as protein, fat, vitamin and mineral.Cortex Eucommiae free amino acid is few, a small amount of protein contained, be with most foodstuff like adequate proteins, namely can be hydrolyzed 8 seed amino acids detected needed by human.The Cortex Eucommiae has regulating action in various degree to immune system, hormonal system, central nervous system, blood circulation and urinary system, the excited Pituitary Adrenalcortical system of Cortex Eucommiae energy, adrenal cortex reinforcing function.Zoopery shows, the Cortex Eucommiae contain a kind of promote human body skin, skeleton, protein collagen in muscle the special composition of composition and decomposition, have and promote metabolism, prevent the function that fails.

Semen Platycladi: sweet is flat.GUIXIN, kidney, large intestine channel.Shennong's Herbal: " cypress is real, and sweet in the mouth is put down, and main palpitation with fear, settling five organs, QI invigorating, except rheumatism numbness, clothes of a specified duration make us moist, beauty, normal hearing and eyesight." Compendium of Material Medica: " nourish heart gas, and profit kidney is dry, and peace soul determines soul, and Fructus Alpiniae Oxyphyllae is allayed excitement." " Semen Platycladi is flat and cold not dry, sweet in the mouth and mending, and Xin Erneng moistens, its gas delicate fragrance, can heart kidney thoroughly, strengthening the spleen stomach." tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.

Ganoderma: the Ganoderma that Ganoderma makes medicine is Ganoderma lucidum (Leyss. Ex Fr.) Karst. and Ganoderma, and its property of medicine is sweet, flat.GUIXIN, liver, spleen, lung, the kidney Five Classics.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.To human liver cancer cell, there is cytotoxicity, also can suppress the release of histamine, there is hepatoprotective effect and there is anti-allergic effects etc.No matter before liver injury occurs or after generation, taking Ganoderma all can the liver protecting, alleviates hepatic injury.Ganoderma can promote that liver is to the metabolism of medicine, poisonous substance, has definite curative effect for toxic hepatitis.Zoopery and clinical trial all show, Ganoderma can coronary artery dilator effectively, increases coronary flow; improve Myocardial Microcirculation, strengthen the supply of myocardium oxygen and energy, therefore; to myocardial ischemia, there is protective effect, treatment and the prevention of coronary heart diseases and angina pectoris etc. can be widely used in.Polysaccharide contained by Ganoderma, polypeptide etc. have obvious function of delaying senility.Extract energy exciting motion suppresses, mobility is reduced, coordination exercise is lacked of proper care, presents the sick effect in dose-dependent town, can curtail sleep to hexobarbital sleep effect, the time that central stimulants caffeine causes spasm and death can be extended, these results show, Ganoderma is inhibition effect to maincenter.

Rhizoma Acori Graminei: nature and flavor are pungent, bitter, temperature.GUIXIN, stomach warp.Can removing dampness whet the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae., keep silent a mouthful dysentery not hungry for gastral cavity painful abdominal mass, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury." not Lu " records it: " warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, and body accumulated heat is not understood, and can do to bathe soup for main deafness, carbuncle skin ulcer.Audition improvement order, beneficial intelligence."

Radix Et Caulis Acanthopanacis Senticosi: acrid in the mouth, hardship, micro-sweet, warm in nature, enters spleen, kidney, heart channel, there is replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, effect of expelling wind and removing dampness, soft for anemofrigid-damp arthralgia, lumbocrural pain, muscles and bones flaccidity, be slow in action, the card such as body weakness with emaciation is weak, traumatic injury, fracture, edema, beriberi, uncontrolled urination are itched.The sweet A of Radix Et Caulis Acanthopanacis Senticosi is carotene, also containing this constituents in people Ginseng.The excretion of cholesterol can be promoted in human body, the too high disease of blood cholesterol level can be prevented and treated.The sweet B of Radix Et Caulis Acanthopanacis Senticosi is Syringa oblata Lindl. element (Syringin), is the main strong composition of Radix Et Caulis Acanthopanacis Senticosi, has short gonad, radioprotective, fatigue-resisting function, has the physiologically active similar to Ren Ginseng Saponin.Radix Et Caulis Acanthopanacis Senticosi is containing super oxidation disproportionation ferment SOD (Superoxide dimutase) complex, SOD has good anti-oxidation function, the effect of human immunity and the attack of opposing free radical can be strengthened, there is antioxidation, body immunity can be strengthened, prevent aging and promotion health.

Herba Physalis pubescentis: nature and flavor: bitter in the mouth; Acid; Cold in nature.Cure mainly: heat clearing away; Diuresis; Removing toxic substances; Detumescence.Main flu; Cough due to lung-heat; Laryngopharynx swelling and pain; Gingival swelling and pain; Jaundice due to damp-heat; Dysentery; Edema; Pyretic stranguria; Pemphigus; Furuncle.

Herba Polygoni polystachyi: nature and flavor: cool in nature, acrid in the mouth.Cure mainly: expelling wind and removing dampness, parasite killing dysentery relieving, heat-clearing and toxic substances removing.Control bacillary dysentery, enteritis, infantile dyspepsia, traumatic injury, rheumatism swells and ache, skin eczema.

Radix Pandani tectorii: nature and flavor: Guangzhou army " conventional Chinese herbal medicine handbook ": " sweet light, cool." cure mainly: cure cold, warm, hepatitis, nephritis, urinary tract infection, traumatic injury.

Basket for holding earth grass: nature and flavor: lightly seasoned; Cold in nature.Cure mainly: clearing away heat and cooling blood; Diuresis.Main air pyretic toothache; Spit blood; Hematuria; Leucorrhea; Dysuria.

Thyreoid Cervi: nature and flavor: taste is micro-salty; Warm in nature.Gui Jing: kidney channel.Cure mainly: eliminating stagnation disappears wart.

Semen thlaspis: nature and flavor: pungent, tepor.1. " herbal classic ": " acrid in the mouth, tepor." 2. " not Lu ": " be nontoxic." cure mainly: control conjunctival congestion and swelling pain and shed tears.

Caulis et Folium Fagopyri esculenti: nature and flavor: " medical center bun is wanted ": " acid, cold." cure mainly: control food of choking, carbuncle; And can stop blooding, meat is disliked in erosion.

Ramulus et folium berchemiae floribundae: nature and flavor: 1. " Fujian traditional herbal medicine ": " sweet, flat." 2. " Luchuan book on Chinese herbal medicine ": " is cold and cool." cure mainly: heat clearing away, removing heat from blood, diuresis, removing toxic substances.Control epistaxis, jaundice, lumbago due to pathogenic wind-dampness, premenstrual abdominal pain, pathogenic wind toxic multiple abscess, wound is red and swollen.

Flos Loropetali (Herba Loropetali): nature and flavor: " east, Fujian book on Chinese herbal medicine ": " property is put down, and taste is micro-sweet puckery." return through: " Fujian east book on Chinese herbal medicine ": " enters lung, spleen, stomach, large intestine four warp." cure mainly: clearing away summer-heat is antipyretic, cough-relieving, hemostasis.Control cough, spitting of blood, seminal emission, excessive thirst, epistaxis, dysentery, has loose bowels, metrorrhagia.1. " Jiangxi traditional herbal medicine ": " control epistaxis." 2. " east, Fujian book on Chinese herbal medicine ": " clearing away summer-heat is antipyretic, and cough-relieving is stopped blooding.Control dry coughing, hemoptysis, excessive thirst, dysentery, have loose bowels."

Fructus metaplexis: nature and flavor: 1. Tang Materia Medica: " taste sweet, acrid, warm, nontoxic." 2. " detailed outline ": " Gan Weixin." cure mainly: nourishing the essence and strengthening QI, promoting regeneration of the tissue and arresting bleeding, removing toxic substances.Control asthenia, sexual impotence, incised wound is hemorrhage.

River-snail operculum: nature and flavor: sweet in the mouth; Property is put down.Cure mainly: removing nebula improving eyesight.Argument nebula.

Match Herba stellariae mediae: nature and flavor: acid is flat.Cure mainly: detoxification and removing stasis, clearing away heat and promoting diuresis, stimulating milk secretion.Cure mainly hemorrhoid, swell and ache, appendicitis, pyretic stranguria, urinary tract infection.

Radix Ophiopogonis: nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Cure mainly: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.Lignum Aquilariae Resinatum: nature and flavor: pungent, bitter, tepor.Gui Jing: return spleen, stomach, kidney channel.Cure mainly: promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.For the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.

Herba sambuci chinensis: nature and flavor: sweet acid, temperature.1. " not Lu ": " sour in the mouth, temperature, poisonous." 2. " choosing of Yunnan Chinese herbal medicine ": " is pungent wet, temperature." 3. " Sichuan medicine will ": " slightly warm in nature, slightly sweet flavor is nontoxic." return through: " Changsha medicine solution ": " enters liver channel of foot-Jueyin." cure mainly: expelling wind and removing dampness, promoting blood circulation to remove blood stasis.Dispelling the wind and dampness pathogens pain, oedema due to nephritis, beriberi edema, dysentery, jaundice, chronic tracheitis, rubella pruritus, erysipelas, skin ulcer swells, traumatic injury, fracture.

Herba Asteris Turbinati: nature and flavor: micro-hardship is cool.Cure mainly: heat-clearing and toxic substances removing, dysentery relieving, antipruritic.

Wherein, when the dosage form of described medicine is collutory, its preparation method comprises the following steps:

Embodiment 1 collutory

The manufacturing process of collutory of the present invention is: get Radix Rehmanniae Preparata 120g, match Herba stellariae mediae 230g, Radix Polygoni Multiflori 300g, Ramulus et folium berchemiae floribundae 280g, Fructus Broussonetiae 220g, Herba Asteris Turbinati 300g, Herba Dendrobii 250g, Herba Polygoni polystachyi 300g, Rhizoma Polygonati 260g, river-snail operculum 200g, Fructus Lycii 190g, Herba Ecliptae 220g, Flos Loropetali (Herba Loropetali) 250g, Fructus Ligustri Lucidi 180g, Lignum Aquilariae Resinatum 200g, Fructus Mori 260g, Radix Ophiopogonis 300g, Radix Angelicae Sinensis 170g, Caulis et Folium Fagopyri esculenti 310g, Radix Codonopsis 300g, basket for holding earth grass 340g, Placenta Hominis 230g, Semen Cuscutae 300g, Herba Physalis pubescentis 340g, Cortex Eucommiae 230g, Radix Pandani tectorii 150g, Semen Platycladi 240g, Fructus metaplexis 270g, Ganoderma 320g, Herba sambuci chinensis 30g, Rhizoma Acori Graminei 330g, Semen thlaspis 250g, Radix Et Caulis Acanthopanacis Senticosi 350g and Thyreoid Cervi 200g,

The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.7 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;

Second step, adding relative to the determining alcohol of the quality 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 36 hours under the condition of 10 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 60 minutes at this, the micron particles of acquisition 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,

3rd step, adds the deionized water relative to mixed powder quality 2 times, decocts 3 hours, filter in the mixed powder that second step obtains, and obtains medicine juice and is collutory.

Embodiment 2 spray

The manufacturing process of spray of the present invention is: get Radix Rehmanniae Preparata 300g, match Herba stellariae mediae 200g, Radix Polygoni Multiflori 150g, Ramulus et folium berchemiae floribundae 240g, Fructus Broussonetiae 150g, Herba Asteris Turbinati 280g, Herba Dendrobii 220g, Herba Polygoni polystachyi 180g, Rhizoma Polygonati 320g, river-snail operculum 200g, Fructus Lycii 170g, Herba Ecliptae 220g, Flos Loropetali (Herba Loropetali) 250g, Fructus Ligustri Lucidi 300g, Lignum Aquilariae Resinatum 220g, Fructus Mori 250g, Radix Ophiopogonis 280g, Radix Angelicae Sinensis 240g, Caulis et Folium Fagopyri esculenti 310g, Radix Codonopsis 260g, basket for holding earth grass 330g, Placenta Hominis 230g, Semen Cuscutae 300g, Herba Physalis pubescentis 310g, Cortex Eucommiae 270g, Radix Pandani tectorii 200g, Semen Platycladi 230g, Fructus metaplexis 300g, Ganoderma 340g, Herba sambuci chinensis 40g, Rhizoma Acori Graminei 330g, Semen thlaspis 250g, Radix Et Caulis Acanthopanacis Senticosi 340g and Thyreoid Cervi 150g,

The first step, mixes Herba sambuci chinensis, Rhizoma Acori Graminei, Semen thlaspis, Radix Et Caulis Acanthopanacis Senticosi and Thyreoid Cervi, add relative to mixture 5 times amount determining alcohol be 65% alcohol reflux 3 times, each 2 hours, filter, filtrate merges, reclaim ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.32, for subsequent use;

Second step, Radix Rehmanniae Preparata, match Herba stellariae mediae, Radix Polygoni Multiflori, Ramulus et folium berchemiae floribundae, Fructus Broussonetiae, Herba Asteris Turbinati, Herba Dendrobii, Herba Polygoni polystachyi, Rhizoma Polygonati, river-snail operculum, Fructus Lycii, Herba Ecliptae, Flos Loropetali (Herba Loropetali), Fructus Ligustri Lucidi, Lignum Aquilariae Resinatum, Fructus Mori, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis et Folium Fagopyri esculenti, Radix Codonopsis, basket for holding earth grass, Placenta Hominis, Semen Cuscutae, Herba Physalis pubescentis, the Cortex Eucommiae, Radix Pandani tectorii, Semen Platycladi, Fructus metaplexis and Ganoderma are mixed in proportion, add relative to mixture 4 times of water gagings, boil 3 hours, filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.27;

3rd step, the described mastic mixing that the first step, second step are obtained, 60 DEG C of reduced vacuum dryings, get dry extract powder; 4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 35 hours;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.002; The time of described heat treated is 30 minutes, and temperature is 100 DEG C;

Embodiment 3 buccal tablet

The manufacturing process of buccal tablet of the present invention is: get Radix Rehmanniae Preparata 310g, match Herba stellariae mediae 220g, Radix Polygoni Multiflori 160g, Ramulus et folium berchemiae floribundae 180g, Fructus Broussonetiae 200g, Herba Asteris Turbinati 270g, Herba Dendrobii 250g, Herba Polygoni polystachyi 300g, Rhizoma Polygonati 320g, river-snail operculum 210g, Fructus Lycii 160g, Herba Ecliptae 240g, Flos Loropetali (Herba Loropetali) 150g, Fructus Ligustri Lucidi 300g, Lignum Aquilariae Resinatum 190g, Fructus Mori 220g, Radix Ophiopogonis 270g, Radix Angelicae Sinensis 210g, Caulis et Folium Fagopyri esculenti 310g, Radix Codonopsis 280g, basket for holding earth grass 340g, Placenta Hominis 220g, Semen Cuscutae 310g, Herba Physalis pubescentis 320g, Cortex Eucommiae 260g, Radix Pandani tectorii 160g, Semen Platycladi 240g, Fructus metaplexis 300g, Ganoderma 350g, Herba sambuci chinensis 30g, Rhizoma Acori Graminei 340g, Semen thlaspis 290g, Radix Et Caulis Acanthopanacis Senticosi 340g and Thyreoid Cervi 220g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 95%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 3 hours, pulverize, sieve, obtain 500 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.003 times of magnesium stearate, granulate, tabletting, makes.

Acute toxicity testing:

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Buccal tablet prepared by embodiments of the invention 3 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage buccal tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: the collutory of the embodiment of the present invention 1 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch the 200 routine kidney-yin deficiency type gingivitis patients coming from the court Stomatology Clinic patient, male 117 people, female 83 people; 16 ~ 68 years old age, average 54 years old, medical history 7 days ~ 5 years, average 3 years 7 months; Wherein, chronic gingivitis 32 example, pubertal gingivitis 22 example, pregnancy gingivitis 44 example, acute papillary gingivitis example 49, trench mouth 53 example; 200 routine patients are divided into collutory treatment group, aerosol therapy group, buccal tablet treatment group and matched group at random, each experimental group 50 people; Two groups of sexes, age, the course of disease, sick kinds are compared, and through statistical procedures, have comparability.

Diagnostic criteria: with reference to the diagnostic criteria about gingivitis in " oral medicine " third edition of the chief editor of an act.And hope according to the traditional Chinese medical science, hear, ask, cut and be dialectically diagnosed as kidney-yin deficiency type gingivitis further.

Therapeutic Method:

In medication therapy groups:

Collutory treatment group: take collutory prepared by the embodiment of the present invention 1, every day 2 times sooner or later respectively once, every 3 days is 1 course for the treatment of;

Aerosol therapy group: take spray prepared by the embodiment of the present invention 2, every day 3 times, every 3 days courses for the treatment of;

Buccal tablet treatment group: use buccal tablet prepared by the embodiment of the present invention 3, every day 3 times, each 1 every 3 days is a course for the treatment of.

Matched group: take compound recipe hibitane gargarism, every day 3 times, 15ml/ time every 3 days is a course for the treatment of.

The standard of curative effect evaluation:

With reference to " oral medicine " third edition and Sun Chuanxing chief editor " clinical disease diagnosis is according to the curing improvement standard " second edition of the chief editor of an act.Cure: pain disappears, and plaque index and sulcular bleeding index all drop to 0, and gingival abscess disappears, outward appearance recovers normal; Effective: pain relief, plaque index and sulcular bleeding index all drop to 1, and gingival abscess disappears, and outward appearance recovers normal substantially; Take a turn for the better: pain relief, plaque index and sulcular bleeding index drop to 2 or 3, and gingival abscess alleviates, appearance investigation; Invalid: symptom, sign are without significant change.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy kidney-yin deficiency type gingivitis of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy kidney-yin deficiency type gingivitis of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Cure number	Effective number	Good revolution	Invalid number	Total effective rate (%)
							Collutory treatment group	50	21	23	5	1	98％
Aerosol therapy group	50	21	22	7	0	100％
							Buccal tablet treatment group	50	19	24	7	0	100％
Matched group	50	7	15	21	7	86％

Table 2 Four composition do not treat after 4 courses for the treatment of cure, effective and improvement number and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Collutory treatment group	49	8（16.3％）	11（22.4％）	14（28.6％）	16（32.7％）
Aerosol therapy group	50	9（18％）	10（20％）	14（28％）	17（34％）
						Buccal tablet treatment group	50	7（14％）	12（24％）	15（30％）	16（32％）
Matched group	43	2（4.7％）	6（13.9％）	9（20.9％）	26（60.5％）

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Treatment group is cured simultaneously, 149 examples of effective and improvement number and matched group is cured, the effective and 43 routine follow-up of patients 1 year half that takes a turn for the better, result is added up, in collutory treatment group 49 example, healing 21 example and effective 23 examples are all without recurrence, 1 case relapsed in 5 examples of improvement, and relapse rate is 2.04%; Cure 21 examples in aerosol therapy group 50 example without recurrence, 1 case relapsed in effective 22 examples, recur 2 examples in 7 examples of improvement, relapse rate is 6%; Cure 19 examples in buccal tablet treatment group 50 example without recurrence, 1 case relapsed in effective 24 examples, recur 2 examples in 7 examples of improvement, relapse rate is 6%; Matched group is cured, effective and improvement number 43 example, and 1 case relapsed in 7 routine patients of healing, recurs 5 examples in effective 15 routine patients, recur 11 examples, relapse rate 39.5% in 21 examples of improvement; Above-mentioned recurrence refers to that patient outcomes reaches healing, effective or after taking a turn for the better, and obviously occurs the symptom before treatment in 1 year half of following up a case by regular visits to.

Model case: Wang, male, 54 years old, because of gingival abscess half a year, gingival sulcus had bacterial plaque, and gingival sulcus is hemorrhage once in a while, is diagnosed as gingivitis, hoped, heard, asks, cuts and be diagnosed as kidney-yin deficiency type gingivitis further in conjunction with the traditional Chinese medical science.Take the buccal tablet of Medications Example 3 of the present invention, every day 3 times, take and substantially cure for 3 days, continue two weeks healing of taking medicine, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat medicine of kidney-yin deficiency type gingivitis and preparation method thereof for one kind, it is characterized in that, comprise following raw medicinal material: Radix Rehmanniae Preparata, match Herba stellariae mediae, Radix Polygoni Multiflori, Ramulus et folium berchemiae floribundae, Fructus Broussonetiae, Herba Asteris Turbinati, Herba Dendrobii, Herba Polygoni polystachyi, Rhizoma Polygonati, river-snail operculum, Fructus Lycii, Herba Ecliptae, Flos Loropetali (Herba Loropetali), Fructus Ligustri Lucidi, Lignum Aquilariae Resinatum, Fructus Mori, Radix Ophiopogonis, Radix Angelicae Sinensis, Caulis et Folium Fagopyri esculenti, Radix Codonopsis, basket for holding earth grass, Placenta Hominis, Semen Cuscutae, Herba Physalis pubescentis, the Cortex Eucommiae, Radix Pandani tectorii, Semen Platycladi, Fructus metaplexis, Ganoderma, Herba sambuci chinensis, Rhizoma Acori Graminei, Semen thlaspis, Radix Et Caulis Acanthopanacis Senticosi and Thyreoid Cervi.

2. the medicine for the treatment of kidney-yin deficiency type gingivitis according to claim 1, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rehmanniae Preparata 10 ~ 35 parts, match Herba stellariae mediae 15 ~ 25 parts, Radix Polygoni Multiflori 10 ~ 32 parts, Ramulus et folium berchemiae floribundae 10 ~ 35 parts, Fructus Broussonetiae 12 ~ 24 parts, Herba Asteris Turbinati 12 ~ 31 parts, Herba Dendrobii 11 ~ 28 parts, Herba Polygoni polystachyi 13 ~ 33 parts, Rhizoma Polygonati 14 ~ 36 parts, river-snail operculum 12 ~ 24 parts, Fructus Lycii 11 ~ 23 parts, Herba Ecliptae 13 ~ 26 parts, Flos Loropetali (Herba Loropetali) 12 ~ 28 parts, Fructus Ligustri Lucidi 13 ~ 32 parts, Lignum Aquilariae Resinatum 10 ~ 23 parts, 10 ~ 27 parts, Fructus Mori, Radix Ophiopogonis 12 ~ 31 parts, Radix Angelicae Sinensis 13 ~ 29 parts, Caulis et Folium Fagopyri esculenti 14 ~ 34 parts, Radix Codonopsis 12 ~ 32 parts, basket for holding earth grass 15 ~ 38 parts, Placenta Hominis 11 ~ 26 parts, Semen Cuscutae 13 ~ 37 parts, Herba Physalis pubescentis 13 ~ 37 parts, the Cortex Eucommiae 16 ~ 31 parts, Radix Pandani tectorii 10 ~ 25 parts, Semen Platycladi 13 ~ 28 parts, Fructus metaplexis 11 ~ 31 parts, Ganoderma 15 ~ 38 parts, Herba sambuci chinensis 3 ~ 5 parts, Rhizoma Acori Graminei 12 ~ 36 parts, Semen thlaspis 14 ~ 32 parts, Radix Et Caulis Acanthopanacis Senticosi 16 ~ 38 parts and Thyreoid Cervi 10 ~ 25 parts.

3. the medicine for the treatment of kidney-yin deficiency type gingivitis according to claim 1 and 2, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rehmanniae Preparata 12 ~ 33 parts, match Herba stellariae mediae 16 ~ 23 parts, Radix Polygoni Multiflori 12 ~ 30 parts, Ramulus et folium berchemiae floribundae 12 ~ 32 parts, Fructus Broussonetiae 14 ~ 23 parts, Herba Asteris Turbinati 15 ~ 30 parts, Herba Dendrobii 13 ~ 25 parts, Herba Polygoni polystachyi 15 ~ 30 parts, Rhizoma Polygonati 15 ~ 34 parts, river-snail operculum 14 ~ 22 parts, Fructus Lycii 14 ~ 22 parts, Herba Ecliptae 14 ~ 25 parts, Flos Loropetali (Herba Loropetali) 14 ~ 26 parts, Fructus Ligustri Lucidi 15 ~ 30 parts, Lignum Aquilariae Resinatum 12 ~ 23 parts, 13 ~ 26 parts, Fructus Mori, Radix Ophiopogonis 14 ~ 30 parts, Radix Angelicae Sinensis 14 ~ 27 parts, Caulis et Folium Fagopyri esculenti 15 ~ 33 parts, Radix Codonopsis 14 ~ 31 parts, basket for holding earth grass 16 ~ 36 parts, Placenta Hominis 12 ~ 25 parts, Semen Cuscutae 14 ~ 33 parts, Herba Physalis pubescentis 15 ~ 35 parts, the Cortex Eucommiae 17 ~ 30 parts, Radix Pandani tectorii 13 ~ 23 parts, Semen Platycladi 15 ~ 26 parts, Fructus metaplexis 13 ~ 30 parts, Ganoderma 16 ~ 36 parts, Herba sambuci chinensis 3 ~ 5 parts, Rhizoma Acori Graminei 14 ~ 35 parts, Semen thlaspis 15 ~ 31 parts, Radix Et Caulis Acanthopanacis Senticosi 17 ~ 36 parts and Thyreoid Cervi 12 ~ 24 parts.

4. the medicine of the treatment kidney-yin deficiency type gingivitis according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rehmanniae Preparata 12 parts, match Herba stellariae mediae 23 parts, Radix Polygoni Multiflori 30 parts, Ramulus et folium berchemiae floribundae 28 parts, Fructus Broussonetiae 22 parts, Herba Asteris Turbinati 30 parts, Herba Dendrobii 25 parts, Herba Polygoni polystachyi 30 parts, Rhizoma Polygonati 26 parts, river-snail operculum 20 parts, Fructus Lycii 19 parts, Herba Ecliptae 22 parts, Flos Loropetali (Herba Loropetali) 25 parts, Fructus Ligustri Lucidi 18 parts, Lignum Aquilariae Resinatum 20 parts, 26 parts, Fructus Mori, Radix Ophiopogonis 30 parts, Radix Angelicae Sinensis 17 parts, Caulis et Folium Fagopyri esculenti 31 parts, Radix Codonopsis 30 parts, basket for holding earth grass 34 parts, Placenta Hominis 23 parts, Semen Cuscutae 30 parts, Herba Physalis pubescentis 34 parts, the Cortex Eucommiae 23 parts, Radix Pandani tectorii 15 parts, Semen Platycladi 24 parts, Fructus metaplexis 27 parts, Ganoderma 32 parts, Herba sambuci chinensis 3 parts, Rhizoma Acori Graminei 33 parts, Semen thlaspis 25 parts, Radix Et Caulis Acanthopanacis Senticosi 35 parts and Thyreoid Cervi 20 parts.

5. the medicine of the treatment kidney-yin deficiency type gingivitis according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rehmanniae Preparata 30 parts, match Herba stellariae mediae 20 parts, Radix Polygoni Multiflori 15 parts, Ramulus et folium berchemiae floribundae 24 parts, Fructus Broussonetiae 15 parts, Herba Asteris Turbinati 28 parts, Herba Dendrobii 22 parts, Herba Polygoni polystachyi 18 parts, Rhizoma Polygonati 32 parts, river-snail operculum 20 parts, Fructus Lycii 17 parts, Herba Ecliptae 22 parts, Flos Loropetali (Herba Loropetali) 25 parts, Fructus Ligustri Lucidi 30 parts, Lignum Aquilariae Resinatum 22 parts, 25 parts, Fructus Mori, Radix Ophiopogonis 28 parts, Radix Angelicae Sinensis 24 parts, Caulis et Folium Fagopyri esculenti 31 parts, Radix Codonopsis 26 parts, basket for holding earth grass 33 parts, Placenta Hominis 23 parts, Semen Cuscutae 30 parts, Herba Physalis pubescentis 31 parts, the Cortex Eucommiae 27 parts, Radix Pandani tectorii 20 parts, Semen Platycladi 23 parts, Fructus metaplexis 30 parts, Ganoderma 34 parts, Herba sambuci chinensis 4 parts, Rhizoma Acori Graminei 33 parts, Semen thlaspis 25 parts, Radix Et Caulis Acanthopanacis Senticosi 34 parts and Thyreoid Cervi 15 parts.

6. the medicine of the treatment kidney-yin deficiency type gingivitis according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Rehmanniae Preparata 31 parts, match Herba stellariae mediae 22 parts, Radix Polygoni Multiflori 16 parts, Ramulus et folium berchemiae floribundae 18 parts, Fructus Broussonetiae 20 parts, Herba Asteris Turbinati 27 parts, Herba Dendrobii 25 parts, Herba Polygoni polystachyi 30 parts, Rhizoma Polygonati 32 parts, river-snail operculum 21 parts, Fructus Lycii 16 parts, Herba Ecliptae 24 parts, Flos Loropetali (Herba Loropetali) 15 parts, Fructus Ligustri Lucidi 30 parts, Lignum Aquilariae Resinatum 19 parts, 22 parts, Fructus Mori, Radix Ophiopogonis 27 parts, Radix Angelicae Sinensis 21 parts, Caulis et Folium Fagopyri esculenti 31 parts, Radix Codonopsis 28 parts, basket for holding earth grass 34 parts, Placenta Hominis 22 parts, Semen Cuscutae 31 parts, Herba Physalis pubescentis 32 parts, the Cortex Eucommiae 26 parts, Radix Pandani tectorii 16 parts, Semen Platycladi 24 parts, Fructus metaplexis 30 parts, Ganoderma 35 parts, Herba sambuci chinensis 3 parts, Rhizoma Acori Graminei 34 parts, Semen thlaspis 29 parts, Radix Et Caulis Acanthopanacis Senticosi 34 parts and Thyreoid Cervi 22 parts.

7. the preparation method of the medicine of the treatment kidney-yin deficiency type gingivitis according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is collutory, its preparation method comprises the following steps:

8. the preparation method of the medicine of the treatment kidney-yin deficiency type gingivitis according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is spray, its preparation method comprises the following steps:

9. the preparation method of the medicine of the treatment kidney-yin deficiency type gingivitis according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is buccal tablet, its preparation method comprises the following steps: