CN106344778A - Traditional Chinese medicine composition for treating gingivitis caused by asthenia of kidney yin and preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating gingivitis caused by asthenia of kidney yin and preparation method and application of traditional Chinese medicine composition Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
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- A61K36/11—Pteridophyta or Filicophyta (ferns)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a traditional Chinese medicine composition for treating gingivitis caused by asthenia of kidney yin and a preparation and application of the traditional Chinese medicine composition. Active ingredient of the traditional chinese medicine composition includes, by weight, 6-12 parts of fructus ligustri lucidi, 2-6 parts of fructus schisandrae chinensis , 10-15 parts of radix rehmanniae, 6-12 parts of fructus lycii , 3-9 parts of rhizoma drynariae, 5-10 parts of fructus mori, 6-12 parts of radix puerariae, 6-12 parts of rhizoma anemarrhenae, 6-12 parts of eclipta, 6-12 parts of fructus rubi, 9-15 parts of semen sesami nigrum, 15-25 parts of rhizoma dioscoreae. With high compatibility and synergistic effect of different raw materials, the traditional Chinese medicine composition has efficacy of controlling gingival atrophy, gomphiasis and light gingival mucosa swelling.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of Chinese medicine composition treating deficiency of kidney-YIN gingivitiss and its system
Preparation Method and application.
Background technology
Gingivitiss refer to betide gingiva tissue clinic with the inflammation being characterized with gingival hemorrhage during laboratory rodent chow of brushing teeth, many
By oral cavity is unclean, the accumulation of dental plaque, tartar, caused by the stimulation of food impaction, ill fitting prosthesis and cervical cariess;Some patientss are deposited
In whole body risk factor, such as chronic hematopathy, endocrine dysfunction, vitamin c and some drugses impact etc..The traditional Chinese medical science thinks tooth
Caused by how gingivitis are because of stomach internal organs accumulated heat or deficiency of kidney-YIN, flaming up of the ministerial fire.And the patient of gingivitiss often shows stomach tooth caused by deficiency of kidney-YIN
Gingival hemorrhage, gingival atrophy, odontoseisiies and halitosis, if not as good as early treatment, cause periodontitis, periodontitis aggravate gingiva in turn
Atrophy, forms vicious cycle.
Content of the invention
Based on this, the present invention provides a kind of Chinese medicine composition treating gingivitiss.
The concrete technical scheme solving above-mentioned technical problem is as follows:
A kind of Chinese medicine composition treating gingivitiss, the effective ingredient of described Chinese medicine composition is by the raw material of following weight parts
Medicine is prepared from: Fructus Ligustri Lucidi 6-12 part, Fructus Schisandrae Chinensis 2-6 part, Radix Rehmanniae 10-15 part, Fructus Lycii 6-12 part, Rhizoma Drynariae 3-9 part, Mulberry
Mulberry 5-10 part, Radix Puerariae 6-12 part, Rhizoma Anemarrhenae 6-12 part, Herba Ecliptae 6-12 part, Fructus Rubi 6-12 part, Semen Sesami Nigrum 9-15 part, Rhizoma Dioscoreae 15-
25 parts.
In certain embodiments, the effective ingredient of described Chinese medicine composition is prepared from by the crude drug of following weight parts:
Fructus Ligustri Lucidi 7-10 part, Fructus Schisandrae Chinensis 2-5 part, Radix Rehmanniae 11-14 part, Fructus Lycii 7-11 part, Rhizoma Drynariae 4-8 part, Fructus Mori 6-9 part, Pueraria lobota
Root 7-11 part, Rhizoma Anemarrhenae 7-11 part, Herba Ecliptae 7-11 part, Fructus Rubi 7-11 part, Semen Sesami Nigrum 10-14 part, Rhizoma Dioscoreae 18-23 part.
In certain embodiments, the effective ingredient of described Chinese medicine composition is prepared from by the crude drug of following weight parts:
Fructus Ligustri Lucidi 8-9 part, Fructus Schisandrae Chinensis 3-4 part, Radix Rehmanniae 12-13 part, Fructus Lycii 8-9 part, Rhizoma Drynariae 6-7 part, Fructus Mori 6-7 part, Radix Puerariae
8-9 part, Rhizoma Anemarrhenae 8-9 part, Herba Ecliptae 8-9 part, Fructus Rubi 8-9 part, Semen Sesami Nigrum 12-13 part, Rhizoma Dioscoreae 20-21 part.
Another object of the present invention is to providing a kind of preparation method of the Chinese medicine composition treating gingivitiss, including following
Step:
1) take Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Radix Rehmanniae, Fructus Lycii, Rhizoma Drynariae, Fructus Mori, Radix Puerariae, the Rhizoma Anemarrhenae, Herba Ecliptae, Fructus Rubi,
Semen Sesami Nigrum and Rhizoma Dioscoreae decoct, and filter, take filtrate;
2) by step 1) filtrate of gained, it is concentrated into thick paste, you can.
In certain embodiments, step 1) described in decoction number of times be 1-3 time.
Another object of the present invention is to providing a kind of Chinese medicine composition in preparation for treating medicine or the guarantor of gingivitiss
Application in strong product.
A kind of Chinese medicine composition treating gingivitiss of the present invention and its preparation method and application have advantages below
And beneficial effect:
1) Chinese medicine composition compatibility of the present invention is reasonable, all medicines share, plays the effect for the treatment of gingivitiss altogether, especially may be used
Significantly improve the gingival hemorrhage being led to by deficiency of kidney-YIN, gingival atrophy, odontoseisiies, simultaneously to deficiency of kidney-YIN produce dizziness,
Tinnitus, soreness of the waist and knees;Red tongue with a little fluid, thin fur, thready and rapid pulse symptom also has a certain degree of improvement.
2) preparation method of the present invention, simple, convenient.
Specific embodiment
Below with reference to specific embodiment, the present invention will be further described, so that those skilled in the art are clearer
The solution present invention, but and it is not so limited the present invention.
Embodiment 1
The present embodiment is related to a kind of Chinese medicine composition treating gingivitiss, and its effective ingredient is by the crude drug system of following weight
Standby form: Fructus Ligustri Lucidi 8g, Fructus Schisandrae Chinensis 3g, Radix Rehmanniae 12g, Fructus Lycii 8g, Rhizoma Drynariae 7g, Fructus Mori 7g, Radix Puerariae 9g, Rhizoma Anemarrhenae 9g, ink
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 8g, Fructus Rubi 9g, Semen Sesami Nigrum 13g, Rhizoma Dioscoreae 20g.
The preparation method of the Chinese medicine composition of above-mentioned treatment gingivitiss, comprises the following steps:
1) take Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Radix Rehmanniae, Fructus Lycii, Rhizoma Drynariae, Fructus Mori, Radix Puerariae, the Rhizoma Anemarrhenae, Herba Ecliptae, Fructus Rubi,
Semen Sesami Nigrum and Rhizoma Dioscoreae decoct 3 times, filter, take filtrate;
2) by step 1) filtrate of gained, it is concentrated into thick paste (relative density is 1.30-1.35), you can.
Embodiment 2
The present embodiment is related to a kind of Chinese medicine composition treating gingivitiss, and its effective ingredient is by the crude drug system of following weight
Standby form: Fructus Ligustri Lucidi 6g, Fructus Schisandrae Chinensis 6g, Radix Rehmanniae 10g, Fructus Lycii 12g, Rhizoma Drynariae 3g, Fructus Mori 10g, Radix Puerariae 12g, the Rhizoma Anemarrhenae
12g, Herba Ecliptae 6g, Fructus Rubi 12g, Semen Sesami Nigrum 9g, Rhizoma Dioscoreae 25g.
The preparation method of the Chinese medicine composition of above-mentioned treatment gingivitiss is with reference to embodiment 1.
Embodiment 3
The present embodiment is related to a kind of Chinese medicine composition treating gingivitiss, and its effective ingredient is by the crude drug system of following weight
Standby form: Fructus Ligustri Lucidi 10g, Fructus Schisandrae Chinensis 2g, Radix Rehmanniae 14g, Fructus Lycii 7g, Rhizoma Drynariae 8g, Fructus Mori 6g, Radix Puerariae 7g, Rhizoma Anemarrhenae 7g, ink
Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) 11g, Fructus Rubi 7g, Semen Sesami Nigrum 14g, Rhizoma Dioscoreae 18g.
The preparation method of the Chinese medicine composition of above-mentioned treatment gingivitiss is with reference to embodiment 1.
Hereinafter knot clinical data and model case are described further to beneficial effects of the present invention.
Observe the patient that deficiency of kidney-YIN card causes gingivitiss, experiment content is as follows:
1st, diagnosis basis:
A, with gingival hemorrhage or gum between cog pyorrhea, odontoseisiies, impact crunching is cardinal symptom.
B, slow onset, gradually increase, and severe patient develops into denture and loosens.Can there is the periodontal of acute attack in the course of disease
Abscess, local red and swollen heat pain, puss amount is many, with heating.
C, examination of mouth: red swelling of gingiva or atrophy, easy bleeding, root of the tooth a surname's dew, odontoseisiies.Attachment tartar, tooth on tooth
Stone.Gum between cog has the periodontal pocket gradually expanding, pyorrhea in bag.There is halitosis.
X line piece around d, root of the tooth, shows the performances such as alveolar ridge absorbs, diastema is broadening.
2nd, syndrome-classification:
Deficiency of kidney-YIN: gingival atrophy, tooth root loosening, the micro- redness of gingival mucosa.Or have dizziness, tinnitus, soreness of the waist and knees.Red tongue
Few Tianjin, thin fur, thready and rapid pulse.
3rd, physical data:
All meet above-mentioned diagnosis basis in 200 patients, be randomly divided into treatment group 1, treatment group 2, treatment group 3 and matched group
Each 50.Treatment group 1: man 26, female 24, age 20-40 year, 29 years old mean age, the course of disease 4 months to 2 years.
Treatment group 2: man 25, female 25, age 23-43 year, 34 years old mean age, the course of disease 6 months to 2 years.
Treatment group 3: man 29, female 21, age 26-50 year, 39 years old mean age, the course of disease 4 months to 2 years.
Matched group: man 20, female 30, age 26-45 year, 40 years old mean age, the course of disease 5 months to 2 years.Four groups in property
Not, the aspect such as age, course of disease no significant difference (p > 0.05), has comparability.
4th, Therapeutic Method:
Treatment group 1, treatment group 2, treatment group 3 take the Chinese medicine composition described in embodiment 1-3 respectively, and matched group is taken:
Fructus Ligustri Lucidi 10g, Fructus Schisandrae Chinensis 2g, Radix Rehmanniae 14g, Fructus Lycii 7g, Rhizoma Drynariae 8g, Fructus Mori 6g, Herba Ecliptae 11g, Fructus Rubi 7g, Fructificatio Amaurodermatis Rudae
Numb 14g, Rhizoma Dioscoreae 18g, preparation method is with reference to embodiment 1, one daily, and a point morning and evening takes for 2 times.It is within 4 weeks a course for the treatment of, treatment group 1,
Treatment group 2, treatment group 3 and matched group all treat 1 course for the treatment of.
5th, efficacy evaluation:
(1) cure: symptom and sign disappear, and periodontal pocket is less than 4mm.
(2) take a turn for the better: sings and symptoms partial disappearance or mitigation.
(3) do not heal: sings and symptoms no significant change.
6th, therapeutic effect
1 course for the treatment of comparitive study of four groups of treatments, treatment group 1 (50), wherein cures 27 (54%), takes a turn for the better 18
(36%), not more 5 (10%);Treatment group 2 (50), wherein cures 24 (48%), and take a turn for the better 17 (34%), not more 9
(18%);Treatment group 3 (50), wherein cures 21 (42%), and take a turn for the better 18 (36%), not more 11 (22%);Matched group
(50), wherein cure 17 (34%), and take a turn for the better 13 (26%), not more 20 (40%).
Relatively understand: the cure rate for the treatment of group 1, treatment group 2 and treatment group 3, improvement rate are substantially better than matched group, and having can
Than property (p < 0.05).In therapeutic process, patient does not have obvious adverse reaction.
Claims (6)
1. a kind of Chinese medicine composition treating gingivitiss it is characterised in that: the effective ingredient of described Chinese medicine composition is by following heavy
The crude drug of amount part is prepared from: Fructus Ligustri Lucidi 6-12 part, Fructus Schisandrae Chinensis 2-6 part, Radix Rehmanniae 10-15 part, Fructus Lycii 6-12 part, osteomiosis
Mend 3-9 part, Fructus Mori 5-10 part, Radix Puerariae 6-12 part, Rhizoma Anemarrhenae 6-12 part, Herba Ecliptae 6-12 part, Fructus Rubi 6-12 part, Semen Sesami Nigrum 9-15
Part, Rhizoma Dioscoreae 15-25 part.
2. treatment gingivitiss according to claim 1 Chinese medicine composition it is characterised in that: the having of described Chinese medicine composition
Effect composition is prepared from by the crude drug of following weight parts: Fructus Ligustri Lucidi 7-10 part, Fructus Schisandrae Chinensis 2-5 part, Radix Rehmanniae 11-14 part, Chinese holly
Fructus Lycii 7-11 part, Rhizoma Drynariae 4-8 part, Fructus Mori 6-9 part, Radix Puerariae 7-11 part, Rhizoma Anemarrhenae 7-11 part, Herba Ecliptae 7-11 part, Fructus Rubi 7-
11 parts, Semen Sesami Nigrum 10-14 part, Rhizoma Dioscoreae 18-23 part.
3. treatment gingivitiss according to claim 2 Chinese medicine composition it is characterised in that: the having of described Chinese medicine composition
Effect composition is prepared from by the crude drug of following weight parts: Fructus Ligustri Lucidi 8-9 part, Fructus Schisandrae Chinensis 3-4 part, Radix Rehmanniae 12-13 part, Fructus Lycii
Sub- 8-9 part, Rhizoma Drynariae 6-7 part, Fructus Mori 6-7 part, Radix Puerariae 8-9 part, Rhizoma Anemarrhenae 8-9 part, Herba Ecliptae 8-9 part, Fructus Rubi 8-9 part, black
Semen Sesami 12-13 part, Rhizoma Dioscoreae 20-21 part.
4. the preparation method of the Chinese medicine composition for the treatment of gingivitiss as described in a kind of any one as claim 1-3, its feature exists
In comprising the following steps:
1) Fructus Ligustri Lucidi, Fructus Schisandrae Chinensis, Radix Rehmanniae, Fructus Lycii, Rhizoma Drynariae, Fructus Mori, Radix Puerariae, the Rhizoma Anemarrhenae, Herba Ecliptae, Fructus Rubi, Fructificatio Amaurodermatis Rudae are taken
Fiber crops and Rhizoma Dioscoreae decoct, and filter, take filtrate;
2) by step 1) filtrate of gained, it is concentrated into thick paste, you can.
5. the preparation method of the Chinese medicine composition for the treatment of gingivitiss according to claim 4 is it is characterised in that step 1) institute
The number of times of the decoction stated is 1-3 time.
6. the Chinese medicine composition of the treatment gingivitiss described in any one of claim 1-3 is used for treating the medicine of gingivitiss in preparation
Or the application in health product.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101152335A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating acute gingivitis |
CN104706978A (en) * | 2015-04-10 | 2015-06-17 | 山东三生新材料科技有限公司 | Medicine for treating gingivitis caused by kidney yin deficiency and preparation method of medicine |
CN104721286A (en) * | 2013-12-19 | 2015-06-24 | 陕西康乐中医药养生研究院 | Gingivitis treatment traditional Chinese medicine |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101152335A (en) * | 2007-09-20 | 2008-04-02 | 吴月 | Traditional Chinese medicine for treating acute gingivitis |
CN104721286A (en) * | 2013-12-19 | 2015-06-24 | 陕西康乐中医药养生研究院 | Gingivitis treatment traditional Chinese medicine |
CN104706978A (en) * | 2015-04-10 | 2015-06-17 | 山东三生新材料科技有限公司 | Medicine for treating gingivitis caused by kidney yin deficiency and preparation method of medicine |
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