CN104705661A - A MCC lactic acid bacteria tablet - Google Patents

Abstract

The invention provides a microcrystalline cellulose (MCC) lactic acid bacteria tablet. The tablet is prepared by using the following raw materials as active ingredients formulated according to weight percentages: spray drying powder of lactic acid bacteria fermentation broth made by Lactobacillus casei fermentation broth 37-42%, D-mannitol 26-32%, lactose 10-12% and MCC 12-18%. The tablet provides a health product which is easy to carry and convenient to take, and can effectively regulate blood lipid and gastrointestinal function disorder.

Description

A kind of MCC lactic acid bacteria tablet

Technical field:

The present invention relates to health product technology field, especially a kind of MCC lactic acid bacteria tablet.

Background technology:

In the modern life, along with changes such as diet, habits and customs, operating pressures, the crowd's quantity suffering from high fat of blood constantly increases, and only in China, hyperlipemia has reached 2.16 hundred million more than at present, and has the trend of rejuvenation gradually.In the crowd of more than 40 years old, more than 70% is more had to suffer from hyperlipemia.Long-term Hyperlipemia, can cause the various diseases such as coronary heart disease, atherosclerotic, apoplexy (cerebral apoplexy), hypertension, cerebral thrombus, this is remarkable especially in mid-aged population.In addition, hyperlipemia also can cause diabetes, fatty liver, cirrhosis, cholelithiasis, pancreatitis, hyperuricemia etc.Thus, hyperlipemia has been the killer of human health.Meanwhile, due to reasons such as dietary structure are unreasonable, drug abuse, increasing people faces the threat of gastrointestinal dysfunction, not only causes diarrhoea, constipation, gastrointestinal inflammation, and serious also will cause the canceration of digestive organ.Lactobacillus casei is bacterial classification conventional in traditional dairy products fermentation, and long-term use has demonstrated their security in practice.They have listed in the spendable bacterial classification catalogue of prebiotic mushroom health food by ministry of Health of China.Current research shows, Lactobacillus casei is one of lactic acid bacteria that health care is the strongest.Lactobacillus significantly can reduce the level of Blood Cholesterol.Find with gas chromatographic analysis Lactobacillus casei fermentating metabolism product, fermented supernatant fluid contains a large amount of lactic acid and a certain amount of butyric acid (or isobutyric acid), acetic acid, positive fumaric acid, six carbon fatty acids, trace amounts of propionic acid, butanedioic acid and micro-antibacterial polypeptide.They are not only to gram-positive bacteria, and have inhibitory action in various degree to Gram-negative bacteria.Large quantity research shows, the organic acid that lactic acid bacteria produces makes pH and Eh in intestines decline, and causes intestines inner acidic environment, to pathogenic entero becteria as shigella dysenteriae, salmonella, staphylococcus aureus, Escherichia coli, clostridium difficile, rotavirus have antagonism.Low pH and Eh can promote intestines peristalsis, in help enteron aisle between various bacterium.Useful equilibrium relation, the flora imbalance of adjustment enteron aisle.Simultaneously, lactic acid bacteria thalline (comprising dead thalline), fragment (peptide glycan mainly on cell wall) have the effect combined the noxious substance of mutagenesis, thus weaken and eliminate the toxic action of these materials, just because of lactic acid bacteria thalline can suppress the growth of harmful intestinal tract bacteria, adsorb harmful components, therefore, it is possible to play the effect regulating gastrointestinal function.SCFA and lactic acid can suppress the growth of putrefactivebacteria in addition, thus decrease toxic amine that these materials produce, indole, indoles, ammonia, scatol, hydrogen sulfide, carcinogen and other poisonous substance, the absorption of ammonia and the generation of urea and effective in cure to renal insufficiency can also be reduced.Acetate, propionate and lactate also may to fat, the Metabolism regulation of lactic acid bacteria, reduce low-density lipoprotein and cholesterol in blood and play a part certain.

MCC is a kind of dietary fiber, and dietary fiber oneself be proved to be adjusting blood lipid, prevention coronary heart disease effect.Dietary fiber can stop body to the absorption of fat, and first this be that it can shorten the time of fat by enteron aisle, and it can absorb bile acid and reduce the dissolubility of cholesterol and triglycerides digestion product micel simultaneously.The sticking dietary fiber of tool can stop micel to the transfer of intestinal absorption cell surface, impels the physiological function of small intestine cells and digestive ferment Secretion to change.The metabolic pathway of cholesterol is mainly by ight soil, and bile acid is the metabolite of cholesterol, in order to supplement the part bile acid excreted by fibers adsorption, just needing more cholesterol to carry out metabolism, body inner cholesterol content is significantly declined.Therefore, at typical condition, suitably increase the intake of dietary fiber, effectively can reduce the uptake of body to cholesterol, reduce body inner cholesterol level, reach the object of prevention and treatment atherosclerotic and coronary heart disease.

Summary of the invention:

Technical problem to be solved by this invention is the health products designing a kind of energy adjusting blood lipid and gastrointestinal function.

The invention provides a kind of not only adjusting blood lipid but also the lactic acid bacteria tablet of gastrointestinal function can be improved, it is characterized in that it be the component of following proportioning is that raw material is made: w/w%

Streptococcus acidi lactici fermented solution spray powder 37-42%D-C6H14O6 26-32% lactose 10-12%MCC12-18%.

Another object of the present invention there is provided the preparation method of above-mentioned lactic acid bacteria tablet, and the method comprises the following steps:

(1) streptococcus acidi lactici fermented solution preparation: the slant strains of Lactobacillus casei is inoculated in through autoclaving 0.11MPa, in the seed culture medium of 19min, cultivate 12.5-16 hour for 37.5 DEG C, obtained seed liquor, the seed liquor of bacterial classification, inoculates into through autoclaving 0.11MPa in the ratio of 1:1000, in the fermentation medium of 19min, cultivate 7.5-8.5 hours for 39 DEG C, obtained streptococcus acidi lactici fermented solution, for subsequent use;

(2) preparation of streptococcus acidi lactici fermented solution spray dried powder: after obtained streptococcus acidi lactici fermented solution, ratio in 0.06% adds trehalose, spray-dried, EAT 105-115 DEG C, leaving air temp 75-85 DEG C, moisture evaporation rate 75-85kg/h, obtains streptococcus acidi lactici fermented solution spray powder, for subsequent use;

(3) the dry fine powder of above-mentioned streptococcus acidi lactici fermented solution spray powder with D-C6H14O6, lactose, MCC is mixed by proportioning;

(4) mixed material sieves through 80 orders, and tablet made by then compressing tablet of granulating;

(5) every sheet weight is 0.5 gram, 0.8 gram, 1 gram, 1.2 grams, 1.5 grams.

In preparation of the present invention, zymotic fluid culture medium prescription is as follows:

Sequence number

Material name

Consumption (w/

		w)
			1	Skimmed milk power	7-9
2	Sucrose	7-9
			3	Zinc lactate	0.005
4	Calcium carbonate	0.04-0.6
			5	Ferrous lactate	0.005
6	Vitamin B1	0.008
			7	Vitamin B2	0.008
8	Vitamin E	0.008

All the other tribes 100% that add water

Lactic acid bacteria tablet raw material of the present invention is composed as follows:

Method for making:

Streptococcus acidi lactici fermented solution is that milky glues silk fabric shape liquid, above-mentioned culture medium is through autoclaving (0.11MPa, in seed culture medium 19min), again the slant strains of Lactobacillus casei is inoculated in through autoclaving (0.11MPa, in seed culture medium 19min), cultivate 12.5-16 hour for 37.5 DEG C, obtained seed liquor.The seed liquor of bacterial classification is inoculated in the ratio of 1:1000 and (in the fermentation medium of 0.11MPa, 19min, is cultivated 7.5-8.5 hours for 39 DEG C, obtained streptococcus acidi lactici fermented solution into through autoclaving.

Streptococcus acidi lactici fermented solution spray powder is pale yellow powder, and after fermentation in lactobacillus inoculum to the fermentation culture of embodiment one, the ratio in 0.06% adds trehalose, spray-dried, EAT 105-115 DEG C, leaving air temp 75-85 DEG C, moisture evaporation rate 75-85kg/h, obtains.The dry fine powder of above-mentioned streptococcus acidi lactici fermented solution spray powder with D-C6H14O6, lactose, MCC is mixed by proportioning.Granulate, lactic acid bacteria tablet made by compressing tablet.The present invention be people provide a kind of portable, facilitate easy-to-use nutraceutical.Meanwhile, adopt Lactobacillus casei (adding multivitamin and mineral matter in culture medium) fermenting lactic acid fermented liquid, carry out spraying dry afterwards, spray powder and dietary fiber etc. make product.

Detailed description of the invention:

Embodiment one:

Formula:

All the other are water, make 100 milliliters altogether

Method for making:

Streptococcus acidi lactici fermented solution is that milky glues silk fabric shape liquid, above-mentioned culture medium is through autoclaving (0.11MPa, in seed culture medium 19min), again the slant strains of Lactobacillus casei is inoculated in through autoclaving (0.11MPa, in seed culture medium 19min), cultivate 16 hours for 37.5 DEG C, obtained seed liquor.The seed liquor of bacterial classification is inoculated in the fermentation medium of autoclaving (0.11MPa, 19min) in the ratio of 1:1000, cultivates 7.5 hours for 39 DEG C, obtained streptococcus acidi lactici fermented solution.

Embodiment two

Method for making:

Acid bacteria fermentation liquid spray powder is pale yellow powder, and after fermentation in lactobacillus inoculum to the fermentation culture of embodiment one, the ratio in 0.06% adds trehalose, spray-dried, EAT 115 DEG C, leaving air temp 75 DEG C, moisture evaporation rate 75-85kg/h, obtains.The dry fine powder of above-mentioned streptococcus acidi lactici fermented solution spray powder with D-C6H14O6, lactose, MCC is mixed by proportioning.Granulate, lactic acid bacteria tablet made by compressing tablet.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (1)

1. a MCC lactic acid bacteria tablet, it is characterized in that this lactic acid bacteria tablet is the w/w% that raw material is made by following component: streptococcus acidi lactici fermented solution spray powder 37-42%, D-C6H14O6 26-32%, lactose 10-12%, MCC12-18%, wherein said streptococcus acidi lactici fermented solution spray powder is that Cheesecake lactobacillus ferment liquid is made.