CN104688914A - Traditional Chinese medicine extract for treating dizziness and preparation method of traditional Chinese medicine extract - Google Patents
Traditional Chinese medicine extract for treating dizziness and preparation method of traditional Chinese medicine extract Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine extract for treating dizziness and a preparation method of the traditional Chinese medicine extract. The traditional Chinese medicine extract for treating dizziness is prepared from the following components in parts by weight: 4-9 parts of a uncaria rhynchophylla water extract, 5-12 parts of a raw rehmannia root water extract, 5-11 parts of an astragalus membranaceus ethanol extract, 4-10 parts of a ginkgo leaf ethanol extract, 2-7 parts of 40wt% ethanol water extract of wallich pepper stem and leaf and 3-8 parts of a pepper wort herb ethyl acetate extract. The preparation method of the traditional Chinese medicine extract for treating dizziness comprises the following steps: drying, solvent extraction, vacuum concentration, centrifuging and mixing. The prepared traditional Chinese medicine extract can take a good treatment effect on dizziness quickly.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine extract and preparation method thereof, particularly relate to and a kind ofly treat dizzy Chinese medicine extract and preparation method thereof.
Background technology
Dizzy is a kind of mobility or positional illusion, causes people and surrounding ambient to close to tie up in cerebral cortex and react distortion, produces to rotate, topple over and the sensation such as fluctuating.Self rotation, roll, topple over, wave, drift about, drift along.
Dizzy is the modal performance of vestibular nerve pathological changes.Also may be that unique master of patient assessment states.The difference of patient's educational level of making peace according to each place, patient has varied to dizzy description.General clinically common to have, patient's readme dizziness and blurred vision, very dizzy, or dizzy, dodder along, grogginess, as bysteam, top-heavy, to deflection.Some patients, can also describe time medical, and dimmed, brains is dimmed, insobriety etc.What main suit was usually expressed as that patient oneself confides is exactly dizzy symptom.Treat dizzy Chinese medicine and have Rhizoma Gastrodiae, Poria, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Dioscoreae, Fructus Schisandrae Chinensis, Semen Ziziphi Spinosae, Arillus Longan etc.License notification number is the Chinese medicine formula that disclosed in CN102258703, treatment is dizzy, comprises Rhizoma Gastrodiae, Rhizoma Pinelliae Preparata, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Chaenomelis, the Radix Paeoniae Alba, Caulis Spatholobi, Ramulus Uncariae Cum Uncis, Semen Cassiae, Poria, Radix Glycyrrhizae, the Cortex Eucommiae, Ramulus Cinnamomi, Fructus Lycii, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii.The Chinese medicine formula of this patent has certain cure rate on the vertigo symptoms for the treatment of patient.
Summary of the invention
The technical problem solved: the dizzy Chinese medicine composition of conventional treatment due to its effective ingredient indefinite, it is also poor that it treats dizzy effect, the object of the invention is clearly to treat dizzy composition further, Chinese medicine extract providing a kind of effective treatment dizzy and preparation method thereof.
Technical scheme: the invention discloses and a kind ofly treat dizzy Chinese medicine extract and preparation method thereof, the dizzy Chinese medicine extract of described treatment comprises following composition by weight:
Ramulus Uncariae Cum Uncis water extract 4-9 part,
Radix Rehmanniae water extract 5-12 part,
Radix Astragali ethanol extraction 5-11 part,
Folium Ginkgo ethanol extraction 4-10 part,
Caulis et Folium piperis 40wt% ethanol-water extraction thing 2-7 part,
Marsilea quadrifolia L ethyl acetate extract 3-8 part.
Further, described a kind ofly treat dizzy Chinese medicine extract, comprise following composition by weight:
Ramulus Uncariae Cum Uncis water extract 5-8 part,
Radix Rehmanniae water extract 7-11 part,
Radix Astragali ethanol extraction 6-10 part,
Folium Ginkgo ethanol extraction 6-9 part,
Caulis et Folium piperis 40wt% ethanol-water extraction thing 3-6 part,
Marsilea quadrifolia L ethyl acetate extract 4-7 part.
Treat a preparation method for dizzy Chinese medicine extract, step is as follows:
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, supernatant is collected after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtains Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively;
(2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, after alcohol steep, lixiviating solution is centrifugal respectively, get the supernatant carry out rotary evaporation concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction;
(3) Caulis et Folium piperis is carried out vacuum drying, after drying, carry out mechanical activation comminution, then powder 40wt% ethanol water is carried out stirring extraction, centrifugalize after extracting, then vacuum concentration is carried out in the supernatant, prepare Caulis et Folium piperis 40wt% ethanol-water extraction thing;
(4) Marsilea quadrifolia L is pulverized, carry out stirring by ethyl acetate after pulverizing and extract, be separated with centrifuge after extraction, then vacuum concentration is carried out in the supernatant, prepare Marsilea quadrifolia L ethyl acetate extract;
(5) finally hook taking rattan water extract is 4-9 part by weight respectively, Radix Rehmanniae water extract is 5-12 part, Radix Astragali ethanol extraction is 5-11 part, Folium Ginkgo ethanol extraction is 4-10 part, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 2-7 part, Marsilea quadrifolia L ethyl acetate extract is 3-8 part, be mixed to evenly, for treating dizzy Chinese medicine extract.
Described a kind of preparation method for the treatment of dizzy Chinese medicine extract, carry out hot extraction temperature to Ramulus Uncariae Cum Uncis and Radix Rehmanniae in step (1) and be 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h.
Described a kind of preparation method for the treatment of dizzy Chinese medicine extract, carry out alcohol steep temperature to the Radix Astragali and Folium Ginkgo in step (2) and be 45 DEG C, feed liquid weight ratio is 1:10, and hot extraction time is 3h.
Described a kind of preparation method for the treatment of dizzy Chinese medicine extract, when extracting Caulis et Folium piperis in step (3), Extracting temperature is for being 60 DEG C, and feed liquid weight ratio is 1:7, and hot extraction time is 2h.
Described a kind of preparation method for the treatment of dizzy Chinese medicine extract, when extracting Marsilea quadrifolia L in step (4), Extracting temperature is for being 50 DEG C, and feed liquid weight ratio is 1:5, and hot extraction time is 4h.
Described a kind of preparation method for the treatment of dizzy Chinese medicine extract, the middle Ramulus Uncariae Cum Uncis water extract of step (5) is 5-8 part, Radix Rehmanniae water extract is 7-11 part, Radix Astragali ethanol extraction is 6-10 part, Folium Ginkgo ethanol extraction is 6-9 part, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 3-6 part, Marsilea quadrifolia L ethyl acetate extract is 4-7 part.
Beneficial effect: the dizzy Chinese medicine extract for the treatment of of the present invention has carried out extraction and isolation to the effective ingredient in Ramulus Uncariae Cum Uncis, Radix Rehmanniae, the Radix Astragali, Folium Ginkgo, Caulis et Folium piperis and Marsilea quadrifolia L, further increase it and treat dizzy specific aim, the vertigo symptoms of patient can be treated fast and effectively.When Ramulus Uncariae Cum Uncis water extract be 5-8 part, Radix Rehmanniae water extract is 7-11 part, Radix Astragali ethanol extraction is 6-10 part, Folium Ginkgo ethanol extraction is 6-9 part, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 3-6 part, Marsilea quadrifolia L ethyl acetate extract is 4-7 part time its effect better.
Detailed description of the invention
Embodiment 1
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, hot extraction temperature is 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, collect supernatant after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtain Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively; (2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, extraction temperature is 45 DEG C, feed liquid weight ratio is 1:10, hot extraction time is 3h, after alcohol steep, lixiviating solution is respectively centrifugal, gets the supernatant and carries out rotary evaporation and concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction; (3) Caulis et Folium piperis is carried out vacuum drying, mechanical activation comminution is carried out after drying, again powder 40wt% ethanol water is carried out stirring to extract, Extracting temperature is for being 60 DEG C, feed liquid weight ratio is 1:7, and hot extraction time is 2h, centrifugalize after extracting, again vacuum concentration is carried out in the supernatant, prepare Caulis et Folium piperis 40wt% ethanol-water extraction thing; (4) Marsilea quadrifolia L pulverized, carry out stirring by ethyl acetate after pulverizing and extract, Extracting temperature is for being 50 DEG C, feed liquid weight ratio is 1:5, and hot extraction time is 4h, is separated after extraction with centrifuge, again vacuum concentration is carried out in the supernatant, prepare Marsilea quadrifolia L ethyl acetate extract; (5) finally hook taking rattan water extract is 4 parts by weight respectively, Radix Rehmanniae water extract is 12 parts, Radix Astragali ethanol extraction is 11 parts, Folium Ginkgo ethanol extraction is 4 parts, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 2 parts, Marsilea quadrifolia L ethyl acetate extract is 8 parts, be mixed to evenly, for treating dizzy Chinese medicine extract.
Embodiment 2
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, hot extraction temperature is 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, collect supernatant after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtain Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively; (2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, extraction temperature is 45 DEG C, feed liquid weight ratio is 1:10, hot extraction time is 3h, after alcohol steep, lixiviating solution is respectively centrifugal, gets the supernatant and carries out rotary evaporation and concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction; (3) Caulis et Folium piperis is carried out vacuum drying, mechanical activation comminution is carried out after drying, again powder 40wt% ethanol water is carried out stirring to extract, Extracting temperature is for being 60 DEG C, feed liquid weight ratio is 1:7, and hot extraction time is 2h, centrifugalize after extracting, again vacuum concentration is carried out in the supernatant, prepare Caulis et Folium piperis 40wt% ethanol-water extraction thing; (4) Marsilea quadrifolia L pulverized, carry out stirring by ethyl acetate after pulverizing and extract, Extracting temperature is for being 50 DEG C, feed liquid weight ratio is 1:5, and hot extraction time is 4h, is separated after extraction with centrifuge, again vacuum concentration is carried out in the supernatant, prepare Marsilea quadrifolia L ethyl acetate extract; (5) finally hook taking rattan water extract is 9 parts by weight respectively, Radix Rehmanniae water extract is 5 parts, Radix Astragali ethanol extraction is 5 parts, Folium Ginkgo ethanol extraction is 10 parts, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 7 parts, Marsilea quadrifolia L ethyl acetate extract is 3 parts, be mixed to evenly, for treating dizzy Chinese medicine extract.
Embodiment 3
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, hot extraction temperature is 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, collect supernatant after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtain Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively; (2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, extraction temperature is 45 DEG C, feed liquid weight ratio is 1:10, hot extraction time is 3h, after alcohol steep, lixiviating solution is respectively centrifugal, gets the supernatant and carries out rotary evaporation and concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction; (3) Caulis et Folium piperis is carried out vacuum drying, mechanical activation comminution is carried out after drying, again powder 40wt% ethanol water is carried out stirring to extract, Extracting temperature is for being 60 DEG C, feed liquid weight ratio is 1:7, and hot extraction time is 2h, centrifugalize after extracting, again vacuum concentration is carried out in the supernatant, prepare Caulis et Folium piperis 40wt% ethanol-water extraction thing; (4) Marsilea quadrifolia L pulverized, carry out stirring by ethyl acetate after pulverizing and extract, Extracting temperature is for being 50 DEG C, feed liquid weight ratio is 1:5, and hot extraction time is 4h, is separated after extraction with centrifuge, again vacuum concentration is carried out in the supernatant, prepare Marsilea quadrifolia L ethyl acetate extract; (5) finally hook taking rattan water extract is 8 parts by weight respectively, Radix Rehmanniae water extract is 11 parts, Radix Astragali ethanol extraction is 10 parts, Folium Ginkgo ethanol extraction is 6 parts, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 3 parts, Marsilea quadrifolia L ethyl acetate extract is 4 parts, be mixed to evenly, for treating dizzy Chinese medicine extract.
Embodiment 4
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, hot extraction temperature is 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, collect supernatant after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtain Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively; (2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, extraction temperature is 45 DEG C, feed liquid weight ratio is 1:10, hot extraction time is 3h, after alcohol steep, lixiviating solution is respectively centrifugal, gets the supernatant and carries out rotary evaporation and concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction; (3) Caulis et Folium piperis is carried out vacuum drying, mechanical activation comminution is carried out after drying, again powder 40wt% ethanol water is carried out stirring to extract, Extracting temperature is for being 60 DEG C, feed liquid weight ratio is 1:7, and hot extraction time is 2h, centrifugalize after extracting, again vacuum concentration is carried out in the supernatant, prepare Caulis et Folium piperis 40wt% ethanol-water extraction thing; (4) Marsilea quadrifolia L pulverized, carry out stirring by ethyl acetate after pulverizing and extract, Extracting temperature is for being 50 DEG C, feed liquid weight ratio is 1:5, and hot extraction time is 4h, is separated after extraction with centrifuge, again vacuum concentration is carried out in the supernatant, prepare Marsilea quadrifolia L ethyl acetate extract; (5) finally hook taking rattan water extract is 5 parts by weight respectively, Radix Rehmanniae water extract is 7 parts, Radix Astragali ethanol extraction is 6 parts, Folium Ginkgo ethanol extraction is 9 parts, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 6 parts, Marsilea quadrifolia L ethyl acetate extract is 7 parts, be mixed to evenly, for treating dizzy Chinese medicine extract.
Embodiment 5
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, hot extraction temperature is 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, collect supernatant after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtain Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively; (2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, extraction temperature is 45 DEG C, feed liquid weight ratio is 1:10, hot extraction time is 3h, after alcohol steep, lixiviating solution is respectively centrifugal, gets the supernatant and carries out rotary evaporation and concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction; (3) Caulis et Folium piperis is carried out vacuum drying, mechanical activation comminution is carried out after drying, again powder 40wt% ethanol water is carried out stirring to extract, Extracting temperature is for being 60 DEG C, feed liquid weight ratio is 1:7, and hot extraction time is 2h, centrifugalize after extracting, again vacuum concentration is carried out in the supernatant, prepare Caulis et Folium piperis 40wt% ethanol-water extraction thing; (4) Marsilea quadrifolia L pulverized, carry out stirring by ethyl acetate after pulverizing and extract, Extracting temperature is for being 50 DEG C, feed liquid weight ratio is 1:5, and hot extraction time is 4h, is separated after extraction with centrifuge, again vacuum concentration is carried out in the supernatant, prepare Marsilea quadrifolia L ethyl acetate extract; (5) finally hook taking rattan water extract is 6 parts by weight respectively, Radix Rehmanniae water extract is 9 parts, Radix Astragali ethanol extraction is 8 parts, Folium Ginkgo ethanol extraction is 7 parts, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 5 parts, Marsilea quadrifolia L ethyl acetate extract is 6 parts, be mixed to evenly, for treating dizzy Chinese medicine extract.
Comparative example 1
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, hot extraction temperature is 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, collect supernatant after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtain Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively; (2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, extraction temperature is 45 DEG C, feed liquid weight ratio is 1:10, hot extraction time is 3h, after alcohol steep, lixiviating solution is respectively centrifugal, gets the supernatant and carries out rotary evaporation and concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction; (3) finally hook taking rattan water extract is 4 parts by weight respectively, Radix Rehmanniae water extract is 12 parts, Radix Astragali ethanol extraction is 11 parts, Folium Ginkgo ethanol extraction is 4 parts, is mixed to evenly, for treating dizzy Chinese medicine extract.
Comparative example 2
License notification number is the Chinese medicine formula that disclosed in CN102258703, treatment is dizzy, gets 10 parts, Rhizoma Gastrodiae, Rhizoma Pinelliae Preparata 10 parts, Radix Angelicae Sinensis 10 parts, Rhizoma Chuanxiong 10 parts, Fructus Chaenomelis 10 parts, the Radix Paeoniae Alba 10 parts, Caulis Spatholobi 10 parts, Ramulus Uncariae Cum Uncis 10 parts, Semen Cassiae 10 parts, 10 parts, Poria, 7 parts, Radix Glycyrrhizae, the Cortex Eucommiae 10 parts, Ramulus Cinnamomi 10 parts, Fructus Lycii 1 part, Radix Saposhnikoviae 10 parts, Rhizoma Et Radix Notopterygii 10 parts by weight.Above-mentioned Chinese medicine composition is decocted, gets decoction liquor simmer down to concentrate.
Patients with vertigo is divided into 7 groups at random, often organizing number is 20 people, and each patient takes Chinese medicine extract or the concentrate of the above embodiments and comparative example every day, and every day takes 2g, the cycle of taking is 1 month, observes the dizzy healing of patient, effective, invalid situation after 1 month.Concrete condition is as follows:
| Cure number | Significant figure | Invalid number | |
| Embodiment 1 | 11 | 8 | 1 |
| Embodiment 2 | 12 | 7 | 1 |
| Embodiment 3 | 15 | 5 | 0 |
| Embodiment 4 | 16 | 4 | 0 |
| Embodiment 5 | 19 | 1 | 0 |
| Comparative example 1 | 7 | 7 | 6 |
| Comparative example 2 | 10 | 5 | 5 |
Claims (8)
1. treat a dizzy Chinese medicine extract, it is characterized in that the dizzy Chinese medicine extract of described treatment comprises following composition by weight:
Ramulus Uncariae Cum Uncis water extract 4-9 part,
Radix Rehmanniae water extract 5-12 part,
Radix Astragali ethanol extraction 5-11 part,
Folium Ginkgo ethanol extraction 4-10 part,
Caulis et Folium piperis 40wt% ethanol-water extraction thing 2-7 part,
Marsilea quadrifolia L ethyl acetate extract 3-8 part.
2. according to claim 1ly a kind ofly treat dizzy Chinese medicine extract, it is characterized in that the dizzy Chinese medicine extract of described treatment comprises following composition by weight:
Ramulus Uncariae Cum Uncis water extract 5-8 part,
Radix Rehmanniae water extract 7-11 part,
Radix Astragali ethanol extraction 6-10 part,
Folium Ginkgo ethanol extraction 6-9 part,
Caulis et Folium piperis 40wt% ethanol-water extraction thing 3-6 part,
Marsilea quadrifolia L ethyl acetate extract 4-7 part.
3. treat a preparation method for dizzy Chinese medicine extract, it is characterized in that described preparation method step is as follows:
(1) pulverize after Ramulus Uncariae Cum Uncis and Radix Rehmanniae drying respectively respectively, heating lixiviate is carried out with water respectively after pulverizing, after water heating lixiviate, respectively Ramulus Uncariae Cum Uncis is separated by centrifugal with precipitation with Radix Rehmanniae extracting solution, supernatant is collected after separation, supernatant is carried out Vacuum film evaporation solvent, after being evaporated solvent, obtains Ramulus Uncariae Cum Uncis water extract and Radix Rehmanniae water extract respectively;
(2) Radix Astragali and Folium Ginkgo vacuum drying is separately got again, after vacuum drying, the Radix Astragali and Folium Ginkgo are carried out lixiviate with ethanol respectively, after alcohol steep, lixiviating solution is centrifugal respectively, get the supernatant carry out rotary evaporation concentrate, collect extract, be respectively Radix Astragali ethanol extraction and Folium Ginkgo ethanol extraction;
(3) Caulis et Folium piperis is carried out vacuum drying, after drying, carry out mechanical activation comminution, then powder 40wt% ethanol water is carried out stirring extraction, centrifugalize after extracting, then vacuum concentration is carried out in the supernatant, prepare Caulis et Folium piperis 40wt% ethanol-water extraction thing;
(4) Marsilea quadrifolia L is pulverized, carry out stirring by ethyl acetate after pulverizing and extract, be separated with centrifuge after extraction, then vacuum concentration is carried out in the supernatant, prepare Marsilea quadrifolia L ethyl acetate extract;
(5) finally hook taking rattan water extract is 4-9 part by weight respectively, Radix Rehmanniae water extract is 5-12 part, Radix Astragali ethanol extraction is 5-11 part, Folium Ginkgo ethanol extraction is 4-10 part, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 2-7 part, Marsilea quadrifolia L ethyl acetate extract is 3-8 part, be mixed to evenly, for treating dizzy Chinese medicine extract.
4. a kind of preparation method for the treatment of dizzy Chinese medicine extract according to claim 3, it is characterized in that carrying out hot extraction temperature to Ramulus Uncariae Cum Uncis and Radix Rehmanniae in step (1) is 55 DEG C, feed liquid weight ratio is 1:6, and hot extraction time is 5h.
5. a kind of preparation method for the treatment of dizzy Chinese medicine extract according to claim 3, it is characterized in that carrying out alcohol steep temperature to the Radix Astragali and Folium Ginkgo in step (2) is 45 DEG C, feed liquid weight ratio is 1:10, and hot extraction time is 3h.
6. a kind of preparation method for the treatment of dizzy Chinese medicine extract according to claim 3, when it is characterized in that extracting Caulis et Folium piperis in step (3), Extracting temperature is for being 60 DEG C, and feed liquid weight ratio is 1:7, and hot extraction time is 2h.
7. a kind of preparation method for the treatment of dizzy Chinese medicine extract according to claim 3, when it is characterized in that extracting Marsilea quadrifolia L in step (4), Extracting temperature is for being 50 DEG C, and feed liquid weight ratio is 1:5, and hot extraction time is 4h.
8. a kind of preparation method for the treatment of dizzy Chinese medicine extract according to claim 3, is characterized in that in step (5), Ramulus Uncariae Cum Uncis water extract is 5-8 part, Radix Rehmanniae water extract is 7-11 part, Radix Astragali ethanol extraction is 6-10 part, Folium Ginkgo ethanol extraction is 6-9 part, Caulis et Folium piperis 40wt% ethanol-water extraction thing is 3-6 part, Marsilea quadrifolia L ethyl acetate extract is 4-7 part.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103655896A (en) * | 2012-09-26 | 2014-03-26 | 任巧娥 | Natural traditional Chinese medicine |
| CN103877244A (en) * | 2012-12-21 | 2014-06-25 | 天士力制药集团股份有限公司 | Medicinal composition for treating headache and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655896A (en) * | 2012-09-26 | 2014-03-26 | 任巧娥 | Natural traditional Chinese medicine |
| CN103877244A (en) * | 2012-12-21 | 2014-06-25 | 天士力制药集团股份有限公司 | Medicinal composition for treating headache and preparation method thereof |
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Application publication date: 20150610 |
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