CN104688808A - Acne cream and preparing method thereof - Google Patents
Acne cream and preparing method thereof Download PDFInfo
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- CN104688808A CN104688808A CN201510147697.XA CN201510147697A CN104688808A CN 104688808 A CN104688808 A CN 104688808A CN 201510147697 A CN201510147697 A CN 201510147697A CN 104688808 A CN104688808 A CN 104688808A
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Abstract
The invention relates to the technical field of drugs for skin diseases, in particular to acne cream and a preparing method thereof. The acne cream is made from terbinafine hydrochloride, rifampicin, clindamycin, borneol, puerarin powder, poria cocos powder and dandelion. By means of compatibility of medicines contained in the acne cream, the acne cream can comprehensively treat pathomycete, bacteria and viruses which cause acne in the view of Western medicine and heat, poison and dampness which cause acne in the view of traditional Chinese medicine, treatment effect is thorough and remarkable, and patients who have acne can be cured comprehensively at low cost within a short period of time so as to return to normal life. Furthermore, the preparing method of the acne cream enables the treatment effect of the acne cream to be guaranteed, operation is easy, production cost is low, and the acne cream is convenient to carry and take.
Description
Technical field
The present invention relates to dermatosis practical technique field, particularly relate to a kind of Whelk-eliminating paste and preparation method thereof.
Background technology
Acne, acne, comedo etc. are the dermatosis of common normal, and especially comedo, teenager all generally perplexs by it to some extent.This kind of dermopathic inducement of acne, acne, comedo is a lot, mainly due to epiderm skin leather bag and sebaceous gland inflammation, be obstructed and cause, specifically can be divided into fungal infection again from western medicine angle, bacteriological infection and viral infection three major types.Existing anti-acne method and medicament categories are also a lot, as: laser therapy, the western medicines such as salicylic acid, clindamycin, metronidazole, dexamethasone, rhodamine toner wet goods plants essential oil is treated.In above-mentioned Therapeutic Method, laser therapy can not eradicate comedo, and has destruction to skin histology; Single western medicine easily makes patient produce drug dependence, and side effect is larger; Plants essential oil therapeutic effect is good, but treatment time is long, and expensive can not be popular acceptance.In addition, also has herbal treatment, as patent of invention 201110421645.9 discloses the Whelk-eliminating paste of a kind of external application use, relation is counted by weight ratio: Margarita powder: Gypsum Fibrosum powder: borneol: Radix Arnebiae (Radix Lithospermi): Radix Et Rhizoma Rhei: Fructus Tritici aestivi: Rhizoma Smilacis Glabrae: Herba Violae japonicae: Herba Cymbopogonis Citrari: seed of Job's tears=30:15:10:10:5:15:15:15:15:20; For another example patent of invention 200810053192.7 discloses a kind of Whelk-eliminating paste, is made up of agents, counts by weight, Pseudobulbus Bletillae (Rhizoma Bletillae) 0.9-3.8 part, the Radix Angelicae Dahuricae 1.1 ~ 4.5 parts, Radix Scutellariae 0.7 ~ 4.1 part, Flos Magnoliae 1 ~ 2.4 part; These Chinese medicines above-mentioned, from " monarch drug minister makes " angle, achieve good effect in this kind of dermatosis for the treatment of comedo, acne and acne, but Chinese medicine needs dialectical use, and it is only applicable to subset of patients, and treatment cycle is long.
Summary of the invention
The object of the invention is, for prior art Problems existing, provide a kind of Whelk-eliminating paste and preparation method thereof, make these type of dermatosis patients such as acne, acne, comedo eliminate symptom at short notice with low cost, recover orthobiosis.
The technical scheme that the present invention deals with problems is: provide a kind of Whelk-eliminating paste, containing following raw material: TER-HCL, rifampicin, clindamycin, Borneolum Syntheticum, powder of Radix Puerariae, Poria powder and Herba Taraxaci.
In Whelk-eliminating paste of the present invention, preferably, the weight of described each raw material dosage is as follows: TER-HCL 7 ~ 40 parts, rifampicin 0.03 ~ 0.3 part, clindamycin 0.1 ~ 1.2 part, Borneolum Syntheticum 1 ~ 3 part, powder of Radix Puerariae 0.1 ~ 5 part, Poria powder 0.1 ~ 5 part, Herba Taraxaci 0.1 ~ 5 part.
In Whelk-eliminating paste of the present invention, preferably, the weight of described each raw material dosage is as follows: TER-HCL 20 parts, rifampicin 0.3 part, clindamycin 0.6 part, Borneolum Syntheticum 2 parts, powder of Radix Puerariae 1 part, Poria powder 1 part, Herba Taraxaci 1 part.
In Whelk-eliminating paste of the present invention, preferably, the weight of described each raw material dosage is as follows: TER-HCL 30 parts, rifampicin 0.1 part, clindamycin 1 part, Borneolum Syntheticum 3 parts, powder of Radix Puerariae 3 parts, Poria powder 3 parts, Herba Taraxaci 3 parts.
In Whelk-eliminating paste of the present invention, preferably, the weight of described each raw material dosage is as follows: TER-HCL 7 parts, rifampicin 0.03 part, clindamycin 0.1 part, Borneolum Syntheticum 1 part, powder of Radix Puerariae 0.1 part, Poria powder 0.1 part, Herba Taraxaci 0.1 part.
The invention provides the preferred preparation method each raw material being made Whelk-eliminating paste of the present invention, comprise the steps:
(1) TER-HCL, rifampicin, clindamycin, Borneolum Syntheticum, powder of Radix Puerariae, Poria powder and Herba Taraxaci is taken according to the proportioning raw materials of above-mentioned Whelk-eliminating paste;
(2) alleged for step (1) raw material Borneolum Syntheticum and Herba Taraxaci are pulverized respectively;
(3) alleged for step (1) powder of Radix Puerariae and Poria powder are mixed with step (2) gained Borneolum Syntheticum powder and Herba Taraxaci part, stir;
(4) by alleged for step (1) TER-HCL, rifampicin and clindamycin mixing, and stir;
(5) mixed material of step (3) gained mixed material with step (4) gained is mixed, stir, obtain Whelk-eliminating paste.
Preferably, in the preparation method of Whelk-eliminating paste of the present invention, described raw material TER-HCL is unguentum.
Preferably, in the preparation method of Whelk-eliminating paste of the present invention, described rifampicin is the capsule of in-built orange red or dark red powder, in described step (4), when described rifampicin mixes with TER-HCL and clindamycin, use the powder rifampicin in capsule.
Preferably, in the preparation method of Whelk-eliminating paste of the present invention, described clindamycin is solution.
Preferably, in the preparation method of Whelk-eliminating paste of the present invention, in described step (3), described powder of Radix Puerariae, Poria powder, Borneolum Syntheticum powder and Herba Taraxaci powder all cross 200 mesh sieves.
Whelk-eliminating paste of the present invention and preparation method thereof is that inventor has done over one hundred experiment and formula adjustment and carried out developing according to Chinese medicine and western medicine theory and obtain.The present invention is raw materials used all can buy from market, below the above-mentioned raw materials selected in the present invention is described below: raw materials used TER-HCL, rifampicin and clindamycin are Western medicine, wherein, described TER-HCL tool is killed or Antifungi effect, especially the skin problem caused fungal infection is effective in cure, when specifically selecting raw material, the preferred TER-HCL emulsifiable paste of described TER-HCL; Described rifampicin to all have multiple pathogenic microorganisms such as aerobic gram positive bacteria and aerobic gram-negative bacterias height antibacterial activity, when specifically selecting raw material, preferred rifampicin capsules; Described clindamycin has therapeutic efficiency to furuncle, carbuncle, abscess and other inflammation caused by gram positive bacteria and the microbial various infection of anaerobism, when specifically selecting raw material, obtains preferably by clindamycin phosphate injection; The pungent bitter in the mouth of raw materials used Borneolum Syntheticum, is slightly cold, GUIXIN, spleen, lung meridian, and tool is had one's ideas straightened out refreshment, clearing away heat to alleviate pain effect; Raw materials used powder of Radix Puerariae is the Radix Puerariae after pulverizing, and Radix Puerariae nature and flavor are pungent, sweet, cool, return spleen, stomach warp, tool expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, yang invigorating stopping leak and rash effect; Raw materials used Poria powder is the Poria after pulverizing, and Poria nature and flavor are sweet, light, flat, GUIXIN, spleen, kidney channel, tool promoting diuresis to eliminate damp pathogen, spleen invigorating and effect of calming the nerves; Raw materials used Herba Taraxaci nature and flavor are bitter, sweet, cold, return liver, stomach warp, effect that tool heat-clearing and toxic substances removing, dampness removing are treating stranguria.
Each taste medicine compatibility comprehensive function in Whelk-eliminating paste provided by the invention, pathogenic heat, poison, wet complete treatment is thought in the pathomycete that comedo is thought in doctor trained in Western medicine, antibacterial, virus and the traditional Chinese medical science, curative effect thoroughly, significantly, make these type of dermatosis patients such as acne, acne, comedo be cured rehabilitation at short notice with low cost comprehensively, recover orthobiosis; In addition, the preparation method of Whelk-eliminating paste provided by the invention makes the curative effect of Whelk-eliminating paste be protected, and simple and easy to operate, production cost is low, gained ointment carries and taking convenience.
Detailed description of the invention
Whelk-eliminating paste provided by the invention, obtain based on the research of Chinese and western medical for many years and clinical experience research, screens active drug, the over one hundred example of clinical observation, has the advantages that instant effect, stable curative effect are reliable, nontoxic, have no side effect.Be specifically described below by embodiment.
The object of embodiment is the regular dosage form illustrating that Whelk-eliminating paste of the present invention can be made, but not for limiting its protection domain or affecting it openly fully.
In following embodiment raw materials used and source as follows: raw material TER-HCL, obtained by the TER-HCL emulsifiable paste of market purchasing, producer is Jiangsu Fubang .Pharm Co., Ltd., authentication code is the accurate word H20093836 of traditional Chinese medicines, often prop up 20g dress, every gram containing main component TER-HCL 0.01g; Raw material rifampicin, is obtained by the rifampicin capsules of market purchasing, and producer is Shenyang Hongqi Pharmaceutical Co., Ltd., and authentication code is the accurate word H21021905 of traditional Chinese medicines, and every capsules content is orange red or dark red powder, and every capsules is containing rifampicin 0.15g; Raw material clindamycin, is obtained by the clindamycin phosphate injection of market purchasing, and producer is Anhui friendship ties Pharmaceutical limited company, and authentication code is the accurate word H20057741 of traditional Chinese medicines, often props up 2ml, often props up containing clindamycin 0.3g; Raw material Borneolum Syntheticum, powder of Radix Puerariae, Poria powder and Herba Taraxaci are purchased by Market of Chinese Materia Medica.It should be noted that, in following embodiment, TER-HCL emulsifiable paste is directly applied, without the need to additionally carrying out TER-HCL extraction; To rifampicin capsules, apply the orange red or dark red powder in its capsule; Clindamycin phosphate injection is directly applied, without the need to additional extractions clindamycin.
Embodiment 1
A kind of Whelk-eliminating paste of the present invention, raw material (g) proportioning is: TER-HCL 20g, rifampicin 0.3g, clindamycin 0.6g, Borneolum Syntheticum 2g, powder of Radix Puerariae 1g, Poria powder 1g, Herba Taraxaci 1g.
Preparation method is as follows:
(1) TER-HCL, rifampicin, clindamycin, Borneolum Syntheticum, powder of Radix Puerariae, Poria powder and Herba Taraxaci is taken according to the proportioning raw materials of above-mentioned Whelk-eliminating paste;
(2) alleged for step (1) raw material Borneolum Syntheticum and Herba Taraxaci are pulverized respectively;
(3) alleged for step (1) powder of Radix Puerariae and Poria powder are mixed with step (2) gained Borneolum Syntheticum powder and Herba Taraxaci part, stir;
(4) by alleged for step (1) TER-HCL, rifampicin and clindamycin mixing, and stir;
(5) mixed material of step (3) gained mixed material with step (4) gained is mixed, stir, obtain Whelk-eliminating paste.
In the above-described embodiments, for ensureing the curative effect of last gained Whelk-eliminating paste, described powder of Radix Puerariae, Poria powder, Borneolum Syntheticum powder and Herba Taraxaci powder all cross 200 mesh sieves.
The usage of gained Whelk-eliminating paste is: smear according to patient's scope, be massaged into absorption, to be evening preferred administration time, once-a-day, until transference cure.
Embodiment 2
A kind of Whelk-eliminating paste of the present invention, raw material (g) proportioning is: TER-HCL 30g, rifampicin 0.1g, clindamycin 1g, Borneolum Syntheticum 3g, powder of Radix Puerariae 3g, Poria powder 3g, Herba Taraxaci 3g.
Preparation method is with embodiment 1.
The usage of gained Whelk-eliminating paste is with embodiment 1.
Embodiment 3
A kind of Whelk-eliminating paste of the present invention, raw material (g) proportioning is: TER-HCL 7g, rifampicin 0.03g, clindamycin 0.1g, Borneolum Syntheticum 1g, powder of Radix Puerariae 0.1g, Poria powder 0.1g, Herba Taraxaci 0.1g.
Preparation method is with embodiment 1.
The usage of gained Whelk-eliminating paste is with embodiment 1.
Embodiment 4
A kind of Whelk-eliminating paste of the present invention, raw material (g) proportioning is: TER-HCL 40g, rifampicin 0.3g, clindamycin 1.2g, Borneolum Syntheticum 3g, powder of Radix Puerariae 5g, Poria powder 5g, Herba Taraxaci 5g.
Preparation method is with embodiment 1.
The usage of gained Whelk-eliminating paste is with embodiment 1.
Application experiment example
For fully showing that Whelk-eliminating paste of the present invention is to acne, acne, this kind for the treatment of for skin disease effect of comedo, before carrying out clinical practice, the various embodiments described above gained Whelk-eliminating paste has been carried out zoopery, be described with the zoopery adopting the Whelk-eliminating paste of embodiment 1 gained to carry out below, but application of the present invention is not limited thereto.
1, animal for research, animal origin and animal symptom are as follows:
(1) 4 common mole cricket, be numbered A, B, C, D respectively, age be respectively Canis familiaris L. A10 month, Canis familiaris L. B8 month, Canis familiaris L. C12 month, Canis familiaris L. D6 month, wherein, Canis familiaris L. A two in ear has breakage, shows as skin pustular eruption, pimple, performance, close to human face's comedo, causes for fungus and staphy lococcus infection through chemical examination; Canis familiaris L. B two in ear cutaneous manifestations is furuncle and phyma, and close to there being hair place to have depilation phenomenon, close to human face's acne, be fungus and enterococcus through chemical examination, co-infection causes; Canis familiaris L. C and Canis familiaris L. D two in ear all without damaged and infection, are healthy normal ear;
(2) 4 common native cats, are numbered a, b, c, d respectively, the age be respectively cat a10 month, cat b8 month, cat c12 month, cat d16 month, wherein, cat a two in ear has breakage, shows as pus born of the same parents, close to the performance of human face's comedo infection period, chemically examine as streptococcus and anaerobic infection; Cat b two in ear breakage shows as redness, a small amount of point-like erythema, but not outstanding skin, through chemical examination without bacteriological infection; Cat c and cat d two in ear, without damaged and infection, are healthy normal ear.
2, therapeutic process and method as follows:
First clean in each for each cat Canis familiaris L. auricular concha with normal saline, by the embodiment of the present invention 1 gained Whelk-eliminating paste uniform application in each Canis familiaris L. auricular concha of each cat on skin, and massage promotes that it absorbs, wherein, for the curative effect of comparative illustration Whelk-eliminating paste of the present invention, on the left of Canis familiaris L. A and Canis familiaris L. B, ear is coated with and touches rifampicin emulsifiable paste, and on the left of cat a and cat b, ear smears clindamycin inj; The coating time is evening, after allowing medicine act on 12 hours on skin, washes off morning next day, continuous use 20 days, and during coating, every day observes the change of skin of medication place.
3, experimental result is as follows:
(1) the phenomenon performances such as Whelk-eliminating paste of the present invention is non-stimulated to Canis familiaris L. C, Canis familiaris L. D, cat c and cat d in ear skin, nothing is irritated;
(2) the right side ear of Canis familiaris L. A and Canis familiaris L. B Whelk-eliminating paste and the left side ear contrast with rifampicin, with the right side ear of Whelk-eliminating paste in medication to thoroughly rehabilitation basic when the 10th day, with the left side ear medication of rifampicin to also having part red and swollen and decortication phenomenon when the 20th day;
(3) the right side ear of cat a Whelk-eliminating paste in medication to thorough rehabilitation when the 12nd day, and with the left side ear of clindamycin medication to the 20th time also have part pus born of the same parents and red and swollenly to exist; The right side ear of cat b Whelk-eliminating paste in medication to thorough rehabilitation when the 5th day, and with the left side ear of clindamycin in medication to just rehabilitation when the 15th day.
4, conclusion: shown by above-mentioned zoopery, Whelk-eliminating paste of the present invention is all effective to causing the various funguses of skin infection, antibacterial, especially has significant curative effect to acne, acne, this kind of dermatosis of comedo.
Clinical practice example
For fully showing that Whelk-eliminating paste of the present invention is to acne, acne, this kind for the treatment of for skin disease effect of comedo, have selected medical history, the state of an illness, age, patient that sex is suitable, embodiment 1, embodiment 2, embodiment 3 and embodiment 4 couples of patients are adopted to carry out therapeutic test respectively, usage is: once a day, often smear Whelk-eliminating paste inferior to affected part after cleaning in evening, and be massaged into absorption, then clean morning next day, be a course for the treatment of with 20 days; Through more than 300 routine clinical observations, within a course for the treatment of, the surface symptoms of patient disappears completely, and pain and sense of discomfort also obviously disappear, and recovers orthobiosis, evident in efficacy.
Typical apply example below by way of painting embodiment 1 gained Whelk-eliminating paste is described, but application of the present invention is not limited thereto.
Application examples 1
Choose acne, acne and comedo patient totally 100 examples, 13 ~ 37 years old age, wherein; Patients with acne 28 example, containing women 20 example, male 8 example; Comedo patient 36 example, containing women 28 example, male 8 example; Acne patient 18 example, containing women 15 example, male 3 example; Pox print patient 18 example, containing women 15 example, male 3 example.Following therapeutic scheme is taked to this 100 routine patient: use Whelk-eliminating paste of the present invention once a day, often smear the embodiment of the present invention 1 gained Whelk-eliminating paste inferior to affected part after cleaning in evening, and be massaged into absorption, clean morning next day again, it was a course for the treatment of with 20 days, continuous use 20 days, further consultation in a week once.
The standard of curative effect evaluation comprises: (1) cures: clinical symptoms disappears completely, and pain and sense of discomfort disappear completely, recovers orthobiosis; (2) effective: whole or cardinal symptom is obviously eliminated, and pain and sense of discomfort obviously disappear, but also there will be slight symptom, and only part recovers orthobiosis; (3) invalid: symptom is without significant change.
Clinical practice experimental result is as follows:
| Cure | Effectively | Invalid | Effective percentage | |
| Acne 28 people | 20 | 8 | 0 | 100％ |
| Comedo 36 people | 28 | 8 | 0 | 100％ |
| Acne 18 people | 15 | 3 | 0 | 100％ |
| Pox prints 18 people | 11 | 7 | 0 | 100％ |
From upper table application experiment result, Whelk-eliminating paste of the present invention has significant curative effect to this kind of dermatosis of acne, acne and comedo.
In addition, for further illustrating the curative effect of Whelk-eliminating paste of the present invention, also having carried out a large amount of clinical comparison experiments, be described for existing conventional rifampicin cream and clindamycin and metronidazole liniment below, but comparative illustration being not limited thereto.
Control experiment example 1
Choose acne, acne and comedo patient totally 100 examples, 16 ~ 33 years old age, wherein; Patients with acne 35 example, containing women 28 example, male 7 example; Comedo patient 28 example, containing women 20 example, male 8 example; Acne patient 25 example, containing women 8 example, male 17 example; Pox print patient 12 example, containing women 6 example, male 6 example.Take following therapeutic scheme to this 100 routine patient: use rifampicin cream once a day, often smear inferior to affected part after cleaning in evening, and be massaged into absorption, then clean morning next day, be a course for the treatment of with 20 days, continuous use 20 days, further consultation in a week once.
The standard of curative effect evaluation comprises: (1) cures: clinical symptoms disappears completely, and pain and sense of discomfort disappear completely, recovers orthobiosis; (2) effective: whole or cardinal symptom is obviously eliminated, and pain and sense of discomfort obviously disappear, but also there will be slight symptom, and only part recovers orthobiosis; (3) invalid: symptom is without significant change.
Experimental result is as follows:
| Cure | Effectively | Invalid | Effective percentage | |
| Acne 35 people | 10 | 20 | 5 | 85.7％ |
| Comedo 28 people | 10 | 14 | 4 | 85.7％ |
| Acne 25 people | 15 | 3 | 7 | 72％ |
| Pox prints 12 people | 1 | 3 | 8 | 33.3％ |
The clinical practice experimental result contrasting the experimental result of above-mentioned rifampicin cream and Whelk-eliminating paste of the present invention is known, and Whelk-eliminating paste curative effect provided by the present invention more thoroughly, significantly.
Control experiment example 2
Choose acne, acne and comedo patient totally 100 examples, 18 ~ 34 years old age, wherein; Patients with acne 30 example, containing women 23 example, male 7 example; Comedo patient 35 example, containing women 28 example, male 7 example; Acne patient 20 example, containing women 7 example, male 13 example; Pox print patient 15 example, containing women 11 example, male 4 example.Following therapeutic scheme is taked to this 100 routine patient: use clindamycin and metronidazole liniment once a day, often smear inferior to affected part after cleaning in evening, and be massaged into absorption, clean morning next day again, be a course for the treatment of with 20 days, continuous use 20 days, further consultation in a week once.
The standard of curative effect evaluation comprises: (1) cures: clinical symptoms disappears completely, and pain and sense of discomfort disappear completely, recovers orthobiosis; (2) effective: whole or cardinal symptom is obviously eliminated, and pain and sense of discomfort obviously disappear, but also there will be slight symptom, and only part recovers orthobiosis; (3) invalid: symptom is without significant change.
Experimental result is as follows:
| Cure | Effectively | Invalid | Effective percentage | |
| Acne 30 people | 10 | 12 | 8 | 73％ |
| Comedo 35 people | 12 | 13 | 0 | 71％ |
| Acne 20 people | 2 | 15 | 3 | 85％ |
| Pox prints 15 people | 2 | 8 | 5 | 66.7％ |
The clinical practice experimental result contrasting the experimental result of above-mentioned clindamycin and metronidazole liniment and Whelk-eliminating paste of the present invention is known, and Whelk-eliminating paste curative effect provided by the present invention more thoroughly, significantly.
Generally, from above-mentioned application experiment result and contrast and experiment, Whelk-eliminating paste of the present invention has significant curative effect to this kind of dermatosis of acne, acne and comedo.
Claims (10)
1. a Whelk-eliminating paste, is characterized in that, containing following raw material: TER-HCL, rifampicin, clindamycin, Borneolum Syntheticum, powder of Radix Puerariae, Poria powder and Herba Taraxaci.
2. Whelk-eliminating paste according to claim 1, it is characterized in that, the weight of described each raw material dosage is as follows: TER-HCL 7 ~ 40 parts, rifampicin 0.03 ~ 0.3 part, clindamycin 0.1 ~ 1.2 part, Borneolum Syntheticum 1 ~ 3 part, powder of Radix Puerariae 0.1 ~ 5 part, Poria powder 0.1 ~ 5 part, Herba Taraxaci 0.1 ~ 5 part.
3. Whelk-eliminating paste according to claim 1, is characterized in that, the weight of described each raw material dosage is as follows: TER-HCL 20 parts, rifampicin 0.3 part, clindamycin 0.6 part, Borneolum Syntheticum 2 parts, powder of Radix Puerariae 1 part, Poria powder 1 part, Herba Taraxaci 1 part.
4. Whelk-eliminating paste according to claim 1, is characterized in that, the weight of described each raw material dosage is as follows: TER-HCL 30 parts, rifampicin 0.1 part, clindamycin 1 part, Borneolum Syntheticum 3 parts, powder of Radix Puerariae 3 parts, Poria powder 3 parts, Herba Taraxaci 3 parts.
5. Whelk-eliminating paste according to claim 1, it is characterized in that, the weight of described each raw material dosage is as follows: TER-HCL 7 parts, rifampicin 0.03 part, clindamycin 0.1 part, Borneolum Syntheticum 1 part, powder of Radix Puerariae 0.1 part, Poria powder 0.1 part, Herba Taraxaci 0.1 part.
6. a preparation method for the Whelk-eliminating paste described in any one of claim 1 to 5, is characterized in that, comprises the steps:
(1) TER-HCL, rifampicin, clindamycin, Borneolum Syntheticum, powder of Radix Puerariae, Poria powder and Herba Taraxaci is taken according to the proportioning raw materials of the Whelk-eliminating paste according to any one of claim 1 to 5;
(2) alleged for step (1) raw material Borneolum Syntheticum and Herba Taraxaci are pulverized respectively;
(3) alleged for step (1) powder of Radix Puerariae and Poria powder are mixed with step (2) gained Borneolum Syntheticum powder and Herba Taraxaci part, stir;
(4) by alleged for step (1) TER-HCL, rifampicin and clindamycin mixing, and stir;
(5) mixed material of step (3) gained mixed material with step (4) gained is mixed, stir, obtain Whelk-eliminating paste.
7. the preparation method of Whelk-eliminating paste according to claim 6, is characterized in that, described raw material TER-HCL is unguentum.
8. the preparation method of Whelk-eliminating paste according to claim 6, it is characterized in that, described rifampicin is the capsule of in-built orange red or dark red powder, in described step (4), when described rifampicin mixes with TER-HCL and clindamycin, use the powder rifampicin in capsule.
9. the preparation method of Whelk-eliminating paste according to claim 6, is characterized in that, described clindamycin is solution.
10. the preparation method of Whelk-eliminating paste according to claim 6, is characterized in that, in described step (3), described powder of Radix Puerariae, Poria powder, Borneolum Syntheticum powder and Herba Taraxaci powder all cross 200 mesh sieves.
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| CN105616884A (en) * | 2016-03-23 | 2016-06-01 | 古东晖 | Ointment for treating acne and preparation method of ointment |
| WO2017062837A1 (en) * | 2015-10-08 | 2017-04-13 | Amd Therapeutics Llc | Treatment of skin disorders by topical administration of vegf inhibitors |
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| WO2017062837A1 (en) * | 2015-10-08 | 2017-04-13 | Amd Therapeutics Llc | Treatment of skin disorders by topical administration of vegf inhibitors |
| JP2018534358A (en) * | 2015-10-08 | 2018-11-22 | エーエムディー セラピューティックス エルエルシー | Treatment of skin disorders by topical administration of VEGF inhibitors |
| US10709702B2 (en) | 2015-10-08 | 2020-07-14 | Amd Therapeutics Llc | Treatment of skin disorders by topical administration of VEGF inhibitors |
| JP7187310B2 (en) | 2015-10-08 | 2022-12-12 | エーエムディー セラピューティックス エルエルシー | Treatment of skin disorders by topical administration of VEGF inhibitors |
| JP2022188061A (en) * | 2015-10-08 | 2022-12-20 | エーエムディー セラピューティックス エルエルシー | Treatment of skin disorders by topical administration of VEGF inhibitors |
| CN105616884A (en) * | 2016-03-23 | 2016-06-01 | 古东晖 | Ointment for treating acne and preparation method of ointment |
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