CN104685344B - 用于化学分析和生物化学分析的光学技术 - Google Patents

用于化学分析和生物化学分析的光学技术 Download PDF

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Publication number
CN104685344B
CN104685344B CN201380050562.0A CN201380050562A CN104685344B CN 104685344 B CN104685344 B CN 104685344B CN 201380050562 A CN201380050562 A CN 201380050562A CN 104685344 B CN104685344 B CN 104685344B
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CN104685344A (zh
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伊母兰·R·马里克
希奥玛拉·L·马德罗
艾丽卡·F·加西亚
阿克塞尔·谢勒
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California Institute of Technology
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California Institute of Technology
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
CN201380050562.0A 2012-08-03 2013-07-22 用于化学分析和生物化学分析的光学技术 Active CN104685344B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261679552P 2012-08-03 2012-08-03
US61/679,552 2012-08-03
PCT/US2013/051461 WO2014022133A1 (en) 2012-08-03 2013-07-22 Optical technique for chemical and biochemical analysis

Publications (2)

Publication Number Publication Date
CN104685344A CN104685344A (zh) 2015-06-03
CN104685344B true CN104685344B (zh) 2017-07-28

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CN201380050562.0A Active CN104685344B (zh) 2012-08-03 2013-07-22 用于化学分析和生物化学分析的光学技术

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US (1) US8873055B2 (enExample)
EP (1) EP2880420A4 (enExample)
CN (1) CN104685344B (enExample)
IN (1) IN2015DN01608A (enExample)
WO (1) WO2014022133A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9518291B2 (en) 2011-12-23 2016-12-13 California Institute Of Technology Devices and methods for biological sample-to-answer and analysis
US8883088B2 (en) 2011-12-23 2014-11-11 California Institute Of Technology Sample preparation devices and systems
US9416343B2 (en) 2012-11-05 2016-08-16 California Institute Of Technology Instruments for biological sample-to-answer devices
JP6086755B2 (ja) * 2013-02-26 2017-03-01 国立大学法人九州大学 マイクロチップを用いた光分析方法および光分析装置、ならびに光分析用処理装置
ES2975059T3 (es) 2016-12-02 2024-07-03 Magtivio B V Método para analizar compuestos en muestras biológicas
CN107179306A (zh) * 2017-05-24 2017-09-19 福州大学 一种基于深度神经网络的ccd生物芯片扫描仪
CN117795318A (zh) * 2021-08-02 2024-03-29 3M创新有限公司 光学系统、光学构造体、光学循环多孔板和光学检测系统

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560712A (en) 1982-08-06 1996-10-01 Kleinerman; Marcos Y. Optical systems for sensing temperature and thermal infrared radiation
SE461560B (sv) 1988-02-24 1990-02-26 Carl Goesta Ardesjoe Anordning foer oevervakning av objekt, saasom kokplattor och elektriska spisar, med avseende paa oeverhettning
US4930361A (en) 1988-12-29 1990-06-05 Precision General, Inc. Portable piston style sample cylinder
US5272518A (en) * 1990-12-17 1993-12-21 Hewlett-Packard Company Colorimeter and calibration system
US5512492A (en) 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5508197A (en) 1994-07-25 1996-04-16 The Regents, University Of California High-speed thermal cycling system and method of use
IT1272870B (it) 1995-01-10 1997-07-01 Ing Ruggeri Guido Dr Apparecchiatura per il prelievo multiplo di campioni liquidi e procedimento per il suo impiego
US6222619B1 (en) 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
US20040057045A1 (en) * 2000-12-21 2004-03-25 Mehdi Vaez-Iravani Sample inspection system
US6572830B1 (en) 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
US7595189B2 (en) 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
US6371370B2 (en) 1999-05-24 2002-04-16 Agilent Technologies, Inc. Apparatus and method for scanning a surface
US6388740B1 (en) 1999-06-22 2002-05-14 Robert A. Levine Method and apparatus for timing intermittent illumination of a sample tube positioned on a centrifuge platen and for calibrating a sample tube imaging system
KR100339379B1 (ko) 1999-10-29 2002-06-03 구자홍 바이오칩과 그의 생체 물질 측정장치 및 측정방법
DE10002566A1 (de) 2000-01-21 2001-08-02 Fraunhofer Ges Forschung Verfahren und Einrichtung zur Bestimmung des Schmelzpunktes und/oder der Bindungskonstante von Substanzen, wie z. B. DNA-Sequenzen, in einer Probe
US6786106B2 (en) 2000-10-24 2004-09-07 Kenneth Alley Apparatus for sampling and testing a specimen
JP2002139418A (ja) 2000-11-01 2002-05-17 Nikon Corp マイクロウエルプレート及びマイクロウエルプレートを備える蛍光検出装置
JP3881176B2 (ja) 2001-01-15 2007-02-14 独立行政法人科学技術振興機構 マイクロバブル作製方法およびその装置
US7265833B2 (en) * 2001-07-25 2007-09-04 Applera Corporation Electrophoretic system with multi-notch filter and laser excitation source
DE10160703C1 (de) 2001-12-11 2003-05-15 Smiths Medical Deutschland Reservoir für Blutentnahme
US20030148391A1 (en) 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US20050059165A9 (en) 2002-01-31 2005-03-17 Davis James O. Universal sample collection and testing system
WO2004047133A2 (en) 2002-11-18 2004-06-03 Washington State University Research Foundation Thermal switch, methods of use and manufacturing methods for same
CN100380034C (zh) 2002-12-04 2008-04-09 斯宾克斯公司 流体的可程控微量控制用装置和方法
CA2467131C (en) 2003-05-13 2013-12-10 Becton, Dickinson & Company Method and apparatus for processing biological and chemical samples
FR2856478B1 (fr) 2003-06-17 2006-05-19 Hemosystem Procede et dispositif pour prelever et melanger des echantillons de liquides
US7136161B2 (en) 2003-08-01 2006-11-14 Shimadzu Corporation Component analyzing apparatus with microchip
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
WO2005028109A2 (en) 2003-09-19 2005-03-31 Applera Corporation Microplates useful for conducting thermocycled nucleotide amplification
NL1024364C2 (nl) * 2003-09-24 2005-03-29 Berli B V Gassensor.
US20050282266A1 (en) 2004-06-21 2005-12-22 Chun-Nan Teng Polymerase chain reactor
US7046359B2 (en) * 2004-06-30 2006-05-16 Chemimage Corporation System and method for dynamic chemical imaging
US7564541B2 (en) * 2004-06-30 2009-07-21 Chemimage Corp System for obtaining images in bright field and crossed polarization modes and chemical images in raman, luminescence and absorption modes
WO2006065739A2 (en) 2004-12-14 2006-06-22 Millennium Pharmaceuticals, Inc A device for aggregating, imaging and analyzing thrombi and a method of use
US20060186346A1 (en) 2005-02-18 2006-08-24 Academia Sinica Method and system for reading microarrays
JP4640797B2 (ja) * 2005-05-30 2011-03-02 株式会社日立製作所 生体分子相互作用測定装置及び測定方法
SE529254C2 (sv) 2005-06-17 2007-06-12 Aamic Ab Optiskt testsystem
TWI310890B (en) 2005-10-13 2009-06-11 Ind Tech Res Inst Apparatus for controlling fluid temperature and method thereof
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
KR100715157B1 (ko) 2006-03-08 2007-05-10 (주)나노스토리지 보이스코일모터 액츄에이터를 이용한 콤보 광학계 바이오칩검출 시스템
CA2650289A1 (en) * 2006-04-25 2008-03-27 University Of South Florida Portable reactor for real-time nucleic acid amplification and detection
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US7629124B2 (en) 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
US20080176755A1 (en) 2006-08-25 2008-07-24 The Trustees Of Columbia University In The City Of New York, Office Of The General Counsel Systems and methods for biodosimetry with biochip using gene expression signatures
GB0704035D0 (en) 2007-03-02 2007-04-11 Smiths Detection Watford Ltd Sample preparation apparatus
FI20070639A0 (fi) 2007-08-23 2007-08-23 Oras Oy Laitteisto ja menetelmä kylpyammeen täyttöön
GB2463549B (en) 2008-07-15 2011-11-23 L3 Technology Ltd Assay device containing amphipathic polymers
US20110151577A1 (en) 2008-08-26 2011-06-23 Jian-Ping Zhang Disposable device for automated biological sample preparation
US8158082B2 (en) 2008-08-29 2012-04-17 Incube Labs, Llc Micro-fluidic device
US9057568B2 (en) 2008-12-16 2015-06-16 California Institute Of Technology Temperature control devices and methods
US8071385B2 (en) 2009-01-16 2011-12-06 Chem Spectra, Inc. Portable explosive or drug detection system
WO2011005487A2 (en) 2009-06-22 2011-01-13 California Institute Of Technology Optical devices and methods for measuring samples
CN101629903B (zh) * 2009-08-19 2011-01-05 南京信息工程大学 散射式云粒子探测器光学系统
US20110104026A1 (en) 2009-11-05 2011-05-05 Seongjun Yoon Apparatus for extracting biochemical materials from biological samples
CN101718696A (zh) * 2009-12-10 2010-06-02 上海交通大学 激光荧光扫描成像-荧光相关光谱单分子探测仪
US8980550B2 (en) 2009-12-15 2015-03-17 California Institute Of Technology Methods for measuring samples using consumer electronic devices and systems
JP5593205B2 (ja) 2010-11-08 2014-09-17 株式会社日立ハイテクノロジーズ 核酸分析装置
US9233369B2 (en) 2010-12-23 2016-01-12 California Institute Of Technology Fluidic devices and fabrication methods for microfluidics

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Publication number Publication date
IN2015DN01608A (enExample) 2015-07-03
CN104685344A (zh) 2015-06-03
US20140036267A1 (en) 2014-02-06
EP2880420A1 (en) 2015-06-10
EP2880420A4 (en) 2016-03-16
WO2014022133A1 (en) 2014-02-06
US8873055B2 (en) 2014-10-28

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