CN104667334B - A kind of foam dressing of the anti-biotic material of zinc containing composite silver and preparation method thereof - Google Patents
A kind of foam dressing of the anti-biotic material of zinc containing composite silver and preparation method thereof Download PDFInfo
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Abstract
The present invention provides foam dressing of a kind of zinc containing composite silver anti-biotic material and preparation method thereof, this foam dressing containing composite silver zinc anti-biotic material includes polyurethane foam plastics and the composite silver zinc anti-biotic material being attached in this polyurethane foam plastics, composite silver zinc anti-biotic material includes Nano Silver, Nano-Zinc and nano inorganic carrier, in composite silver zinc anti-biotic material, the effective content of silver is 10 20% by percentage to the quality, and the effective content of zinc is 20 40%；This composite silver zinc anti-biotic material is scattered in foam dressing in the way of foaming common with foam or ultrasonic wave impregnate.The foam dressing of the anti-biotic material of zinc containing composite silver that the present invention provides can effectively absorb the diffusate of the surface of a wound, and can effectively suppress staphylococcus aureus, pseudomonas aeruginosa, the growth of Candida albicans and breeding.
Description
Technical field
The present invention relates to technical field medical dressing and preparation method thereof, be specifically related to a kind of zinc containing composite silver and resist
Medical dressing of bacterium material and preparation method thereof.
Background technology
Skin belongs to the first immunization barrier of the mankind, skin after wound, burn or ulcer, skin wound
Be easily generated diffusate, fester, toxin and toxic product etc., wherein in diffusate containing substantial amounts of inflammation because of
Son, protease and free radical etc., if these harmful substance extended stationary periods all can slow down wound at skin surface
Healing.
Foam type medical dressing is applicable to wound granulation and forms the phase, and foam type dressing can absorb the unnecessary surface of a wound and ooze
Go out liquid, extraneous foreign matter and part bacterium, the nerve endings that protection exposes can be intercepted simultaneously, ease the pain.
Meanwhile, foam dressing is owing to keeping moistening, thus avoids the excessive vaporization of surface of a wound exudate and form dry scab,
Therefore property mechanical injuries again, the beneficially healing of the surface of a wound will not be produced when more change dressings.
In order to improve antibacterial anti-infection and the promotion healing ability of wound dressing, medical dressing generally with the addition of
Have restraining and sterilizing bacteria effect the carbohydrate that such as the bactericide containing metal, there is bacteriostasis, have antimycotic
The natural drug of effect.Dressing containing metal bactericide, as disclosed in patent CN200410090621.X " one
The wound dressing of kind of containing Ag-Zn composition ", can and the healing that promote wound effectively antibacterial to wound.
Distribution in dressing for the antibiotic effective ingredient, the effect for dressing is most important, especially for containing
For having the dressing of the metal bactericide such as silver-colored zinc, patent 2008802100.5 discloses a kind of polyurethane foam and applies
The preparation method of material, in this invention, by 0.01-20 weight portion to have antibacterial or antiinflammatory action medicine direct
Make an addition to the mixed liquor that foams.The foaming agent prepared by this kind of mode, medicine easily easily occurs dividing in the foam
Cloth is uneven or medicine is directly wrapped up by foam, significantly hinders the performance of efficacy of drugs.
Content of the invention
For overcoming the defect of prior art, it is an object of the invention to provide a kind of antimicrobial component and be more evenly distributed
The foam dressing of the anti-biotic material of zinc containing composite silver.
The technical solution adopted in the present invention is as follows for achieving the above object:
A kind of foam dressing of the anti-biotic material of zinc containing composite silver, this foam dressing include polyurethane foam plastics and
The composite silver zinc anti-biotic material being attached in polyurethane foam plastics；
Described composite silver zinc anti-biotic material includes Nano Silver, Nano-Zinc and nano inorganic carrier, with percent mass
Being 10-20% than the effective content of meter silver, the effective content of zinc is 20-40%, balance of nano inorganic carrier.
As preferably, the raw material of described Nano Silver is selected from Ag2O、Ag2O2、Ag2CO3、Ag2C2H3O3With
Ag2SO4In one or more.
As preferably, the raw material of described Nano-Zinc is selected from ZnSO4、Zn(C2H3O2)2、ZnO、ZnCO3、
Zn(OH)2、ZnSO4·6H2O and Zn (C2H3O2)2·6H2One or more in O.
As preferably, described nano inorganic carrier selected from nano level calcium carbonate, hydrotalcite, titanium dioxide,
One or more in bentonite, diatomite, sepiolite, kaolin.
As preferably, the surface of described foam dressing is also covered with the hypothallus of tack, separator paper layer, water
One or more of colloid layer.
The method preparing the foam dressing of above-mentioned zinc containing composite silver anti-biotic material, comprises the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate and the step 1 of 1.0-2.0 weight portion) described composite silver zinc is antibacterial
Material mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute, and obtain containing anti-biotic material is thick
Performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, the mixing of 0.8-2.6 weight portion water, stir rapidly, add to step 2) institute
State thick performed polymer, immediately high-speed stirred, pour rapidly foaming mould foaming after mixing into, cure 24-28
The foam dressing of the anti-biotic material of zinc containing composite silver is i.e. obtained after little Shi.
The method preparing the foam dressing of above-mentioned zinc containing composite silver anti-biotic material, comprises the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute,
Obtain thick performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight portion water and 1.0-2.0 weight portion step 1) described composite silver zinc
Anti-biotic material mixes, and stirs rapidly, adds to step 2) described thick performed polymer, high-speed stirred immediately,
Pour rapidly foaming mould foaming after mixing into, after curing 24-28 hour, i.e. obtain the anti-biotic material of zinc containing composite silver
Foam dressing.
The method preparing the foam dressing of above-mentioned zinc containing composite silver anti-biotic material, comprises the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare foamed plastics: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
The ratio mixing of 25.0-35.0 parts by weight of toluene diisocyanate, heating stirring, 80-85 DEG C of insulation reaction 80-120
Minute, take 10.0-20.0 weight portion PPG, 0.5-1.5 parts by weight of octanoic acid stannous, 0.5-1.4 weight portion two
Methylethanolamine, 0.5-1.8 weight portion silicon surface active agent, 0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight
Part water mixing, high-speed stirred immediately, pour rapidly foaming mould foaming after mixing into, cure 24-28 hour
Obtain foamed plastics；
3) preparation of the foam dressing containing anti-biotic material: by 90-95 parts per weight dispersing agent, 2.0-4.0 weight portion again
Closing silver zinc anti-biotic material, the mixing of 1.0-7.0 weight portion suspending agent, stir to obtain composite silver zinc anti-biotic material outstanding
Turbid liquid, by step 2) described foamed plastics immerses this suspension, with the frequency effect 2-5min of 28-40Hz,
It is dried, the foam dressing of composite silver zinc anti-biotic material must be contained.
As preferably, described dispersant is purified water or ethanol；
Described suspending agent selected from cataloid, CMC, sodium alginate, CMC-Na one or more.
As preferably, also cover on the surface of the described foam dressing containing anti-biotic material tack hypothallus,
One or more in separator paper layer or hydrocolloid layer.
Compared to existing technology, the beneficial effects of the present invention is:
1) the invention provides foam dressing of a kind of zinc containing composite silver anti-biotic material and preparation method thereof, this bubble
The anti-biotic material of foam dressing is distributed evenly in foamed plastics, can efficiently reduce due to anti-biotic material distribution
The problem such as local bacterial amount reproduction that inequality causes or localized metallic poisoning；
2) the invention provides the foam dressing of a kind of zinc containing composite silver anti-biotic material, the antibacterial material of zinc containing composite silver
Material is adsorbed on nano grade inorganic carrier by Nano Silver zinc antimicrobial component, and this composite silver zinc anti-biotic material has relatively
Big specific surface area and abundant pore structure, be conducive to being sustained in a long time sterilization factors, and maintaining has for a long time
The sterilization factors concentration of effect, sterilization efficiency time is long；
3) foam dressing of the anti-biotic material of zinc containing composite silver that the present invention provides, for the process of wound surface,
Can the penetrating fluid of the Prolonged absorption surface of a wound, fester, toxin etc., the growth of surface of a wound bacterial virus and numerous can be suppressed
Growing, meanwhile, the terminal nerve at the protection surface of a wound, and will not be to wound surface when changing reducing pain
Cause secondary damage；
4) the invention provides the preparation method of the foam dressing of the anti-biotic material of zinc containing composite silver, by anti-biotic material
It is distributed evenly in foam, the anti-biotic material of zinc containing composite silver prepared by the preparation method using the present invention to provide
The specific surface area of anti-biotic material of foam dressing big, contact with bacterium more fully, uses less antibacterial material
Material just can reach more excellent bactericidal effect；
5) preparation method of the foam dressing of the anti-biotic material of zinc containing composite silver that the present invention provides, can subtract effectively
Few foamed plastics is to the embedding of anti-biotic material, the antibacterial effect improving Unit Weight anti-biotic material；
6) foam dressing of the anti-biotic material of zinc containing composite silver that the present invention provides, can be widely applied to infectious wound
Mouth, operative incision, surgery wound, body surface ulcer, the process of various burn traumatic wounds, especially
The antibacterial growth promoting function effect of the more infected wound of diffusate is more significantly.
Detailed description of the invention
The present invention provides the foam dressing of a kind of zinc containing composite silver anti-biotic material, and this foam dressing includes polyurethane foam
Foam plastics and the composite silver zinc anti-biotic material being attached in polyurethane foam plastics；The antibacterial material of described composite silver zinc
Material includes Nano Silver, Nano-Zinc and nano inorganic carrier, and the effective content of silver is by percentage to the quality
10-20%, the effective content of zinc is 20-40%, balance of nano inorganic carrier；This composite silver zinc anti-biotic material
With foamed plastics common foaming or by ultrasonic wave dipping in the way of be scattered in foamed plastics.
The foam dressing of the anti-biotic material of zinc containing composite silver of the present invention can use following three kinds of methods to prepare
Obtain.
Prepare the method one of the foam dressing of above-mentioned zinc containing composite silver anti-biotic material, comprise the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate and the step 1 of 1.0-2.0 weight portion) described composite silver zinc is antibacterial
Material mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute, and obtain containing anti-biotic material is thick
Performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, the mixing of 0.8-2.6 weight portion water, stir rapidly, add to above-mentioned thick
Performed polymer, immediately high-speed stirred, pour rapidly foaming mould foaming into, after curing 24-28 hour after mixing
Obtain the foam dressing of the anti-biotic material of zinc containing composite silver.
Prepare the method two of the foam dressing of above-mentioned zinc containing composite silver anti-biotic material, comprise the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute,
Obtain thick performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight portion water and 1.0-2.0 weight portion step 1) described composite silver zinc
Anti-biotic material mixes, and stirs rapidly, adds to above-mentioned thick performed polymer, high-speed stirred immediately, mixing
Pour rapidly foaming mould foaming after Jun Yun into, after curing 24-28 hour, i.e. obtain the bubble of the anti-biotic material of zinc containing composite silver
Foam dressing.
Prepare the method three of the foam dressing of above-mentioned zinc containing composite silver anti-biotic material, comprise the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare foamed plastics: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
The ratio mixing of 25.0-35.0 parts by weight of toluene diisocyanate, heating stirring, 80-85 DEG C of insulation reaction 80-120
Minute, take 10.0-20.0 weight portion PPG, 0.5-1.5 parts by weight of octanoic acid stannous, 0.5-1.4 weight portion two
Methylethanolamine, 0.5-1.8 weight portion silicon surface active agent, 0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight
Part water mixing, high-speed stirred immediately, pour rapidly foaming mould foaming after mixing into, cure 24-28 hour
Obtain foamed plastics；
3) preparation of the foam dressing containing anti-biotic material: by 90-95 parts per weight dispersing agent, 2.0-4.0 weight portion again
Closing silver zinc anti-biotic material, the mixing of 1.0-7.0 weight portion suspending agent, stir to obtain composite silver zinc anti-biotic material outstanding
Turbid liquid, by step 2) described foamed plastics immerses this suspension, with the frequency effect 2-5min of 28-40Hz,
It is dried, the foam dressing of composite silver zinc anti-biotic material must be contained.
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1: use the foam dressing of the method one preparation anti-biotic material of zinc containing composite silver
1) 220g nanoscale Ag is taken2The stirring mixing of O, 500g nanoscale ZnO, 280g nanometer grade calcium carbonate
Uniformly, it is placed in porcelain dish, puts into high temperature furnace in 800 DEG C of calcinations 3 hours, cross 200 mesh sieves after cooling, i.e.
Prepare composite silver zinc anti-biotic material；
2) in three-necked bottle, add 45.0g dehydration polyethylene glycol, 2.0g glycerine, 31.5g toluene di-isocyanate(TDI)
And 1g above-mentioned composite silver zinc anti-biotic material, heating stirring, 85 DEG C of insulation reaction 80min, obtain containing antibacterial
The thick performed polymer of material；
3) 15g PPG, 0.9g stannous octoate, 1.1g dimethylethanolamine, 1.0g silicon face are taken
Activating agent, 1.0g dichloromethane and 1.5g deionized water, stir rapidly, adds to above-mentioned thick pre-polymerization
Body, immediately high-speed stirred, pour rapidly foaming mould foaming into, i.e. obtain and contain after curing 24 hours after mixing
The flexible polyurethane foams dressing of composite silver zinc anti-biotic material.
Embodiment 2: use the foam dressing of the method two preparation anti-biotic material of zinc containing composite silver
1) 220g nanoscale Ag is taken2CO3, 500g nanoscale ZnO, 280g nano silicone diatomaceous earth, stirring
Mix, be placed in porcelain dish, put into high temperature furnace in 800 DEG C of calcinations 3 hours, after cooling, cross 200 mesh sieves,
I.e. prepare composite silver zinc anti-biotic material；
2) in three-necked bottle, add 45.0g dehydration polyethylene glycol, 2.0g glycerine, 31.5g toluene di-isocyanate(TDI),
Heating stirring, 80 DEG C of insulation reaction 120min, obtain thick performed polymer；
3) 15g PPG, 0.9g stannous octoate, 1.1g dimethylethanolamine, the work of 1.0g silicon face are taken
Property agent, 1.0g dichloromethane and 1.5g deionized water and 1g above-mentioned composite silver zinc anti-biotic material, stirring is all rapidly
Even, add to above-mentioned thick performed polymer, be subsequently adding high-speed stirred immediately, pour into rapidly after mixing and send out
Bubble mould foaming, i.e. obtains the flexible polyurethane foams dressing of the anti-biotic material of zinc containing composite silver after curing 24 hours.
Embodiment 3: use the foam dressing of the method three preparation anti-biotic material of zinc containing composite silver
1) 230g nanoscale AgO, 500g nanoscale ZnO, 270g Nano titanium dioxide, stirring mixing
Uniformly, it is placed in porcelain dish, puts into high temperature furnace in 800 DEG C of calcinations 3 hours, cross 200 mesh sieves after cooling, i.e.
Prepare composite silver zinc anti-biotic material；
2) middle addition 45.0g dehydration polyethylene glycol, 2.0g glycerine, 31.5g toluene diisocynate in three-necked bottle
Ester, heating stirring, 85 DEG C of insulation reaction 80min, add 15g PPG, 0.9g stannous octoate,
The mixing of 1.1g dimethylethanolamine, 1.0g silicon surface active agent, 1.0g dichloromethane and 1.5g deionized water
Liquid, immediately high-speed stirred, pour rapidly foaming mould foaming into after mixing, cures 28 hours soft poly-
Urethane foamed plastics；
3) take 90g ethanol and 4g composite silver zinc anti-biotic material, add 6g cataloid, stir
Obtain the suspension of composite silver zinc anti-biotic material, above-mentioned flexible polyurethane foam is immersed this suspension, with
The frequency effect 5min of 28Hz, is drying to obtain the flexible polyurethane foams dressing of the anti-biotic material of zinc containing composite silver.
Comparative example
1) 230g nanoscale AgO, 500g nanoscale ZnO, 270g Nano titanium dioxide, stirring mixing
Uniformly, composite silver zinc anti-biotic material is prepared；
2) middle addition 45.0g dehydration polyethylene glycol, 2.0g glycerine, 31.5g toluene diisocynate in three-necked bottle
Ester, heating stirring, 85 DEG C of insulation reaction 80min, add 15g PPG, 0.9g stannous octoate,
The mixing of 1.1g dimethylethanolamine, 1.0g silicon surface active agent, 1.0g dichloromethane and 1.5g deionized water
Liquid, immediately high-speed stirred, pour rapidly foaming mould foaming into after mixing, cures 24 hours soft poly-
Urethane foamed plastics；
3) taking 90g ethanol and 4g composite silver zinc anti-biotic material, adding 6g cataloid, stirring is all
Above-mentioned polyurethane foam plastics is immersed in this suspension and impregnates by the even suspension obtaining composite silver zinc anti-biotic material
60min, is drying to obtain the polyurethane foam dressing of the anti-biotic material of zinc containing composite silver.
The foam dressing of the anti-biotic material of zinc containing composite silver prepared by embodiment 1-3, can be done directly on the surface of a wound, or
One in the surface of this foam dressing covers hypothallus, separator paper layer or the hydrocolloid layer with tack,
Wherein one in the polyurethane composite membrane, non-woven fabrics of spraying medical pressure sensitive adhesive for the hypothallus of tack,
The separator paper layer one of Ge Laxin paper or CCK paper or release liners, hydrocolloid layer is fine by PUR, carboxymethyl
Dimension element is received (CMC), polyisobutene, paraffin oil and is prepared from.
Performance test
1.Antibacterial tests
By the foam dressing of the anti-biotic material of zinc containing composite silver prepared by embodiment 1-3, comparative example 1 to several
Planting common representative bacterium and carrying out antibacterial tests, operating procedure is as follows: sample is cut into 1.0cm*1.0cm size,
Weigh 0.75g, put in the conical flask of 250mL, be separately added into 70mLPBS and 5mL bacteria suspension, and
Concentration in PBS for the bacteria suspension is made to be 1 × 104-9×104Conical flask is fixed on vibration and shakes by CFU/mL
On bed, shake 1h with 300r/min, take the sample liquid before shaking and after shaking respectively, after suitably diluting with PBS,
Inoculate plate with agar tilt-pour process, carry out colony counting.Control group should be set simultaneously.The sample that control group uses
For the foam dressing without antimicrobial component, only add PBS and bacteria suspension.Before bacteriostasis rate is for being shaken by test agent
The ratio of the difference of rear average colony number front average colony number with shaking.In terms of percentage.Should meet and not be loaded
Product group clump count is 1 × 104-9×104Between CFU/mL, and this group shaking forward backward averaging clump count difference exists
Within 10%；It is more than 26% by coupons group bacteriostasis rate with the difference compareing print group bacteriostasis rate, be i.e. considered as product
There is antibacterial action.Result is as shown in table 1:
Table 1 antibacterial tests result
From the result explanation of table 1, compared with control group, the foam of the application anti-biotic material of zinc containing composite silver applies
Material is to staphylococcus aureus, pseudomonas aeruginosa, Candida albicans effect a period of time, the number of three kinds of bacterium
Magnitude all reduces 2-3 unit, shows that it has very strong antibacterial effect.Contain from made with comparative example
The antibacterial effect data of the foam dressing of composite silver zinc anti-biotic material understand, prepared by employing conventional impregnation contains
The foam dressing antibacterial effect having composite silver zinc anti-biotic material is prepared far below employing method provided by the present invention
Foam dressing；Knowable to from embodiment, the 1st, the 2nd, the data between 3 compare, foam is applied by different preparation process
The anti-microbial property of material has large effect, uses its anti-microbial property of foam dressing prepared by ultrasonic wave infusion process slightly
Excellent.
2.Clinical testing
The granulation selecting the light degree Ⅱ surface of a wound and diffusate more forms each 36 cases of phase surface of a wound patient, uses local application
The method of the foam dressing of argentiferous zinc anti-biotic material carries out clinical testing, and clinical testing group wound surface uses real
Execute the foam dressing of example the 1st, the 2nd, the argentiferous zinc anti-biotic material prepared by 3, outer layer common gauze wrapping comparison
Group group wound surface uses not argentiferous zinc anti-biotic material foam dressing, and outer layer is wrapped up by common gauze.Clinical real
Testing result to show, the foam dressing of argentiferous zinc anti-biotic material has the effect significantly promoting wound healing.Face
Bed experimental group is shown in Table 2 with control group wound healing situation.
Table 2 clinical trial wound healing situation
Knowable to the data of table 2, the foam dressing of the argentiferous zinc anti-biotic material that the present invention provides, all can help
The light degree Ⅱ surface of a wound granulation more with diffusate forms the healing rate that phase surface of a wound patient reached 100% in 10 days
And the anti-infective rate of holding 100%, and the anti-infective rate of blank test group is respectively less than 90%, and more than 10 days
Healing rate all fails to reach 100%；The foam dressing of the argentiferous zinc anti-biotic material that the present invention provides is used in the granulation phase
Healing days is shorter than and is used in the shallow II degree surface of a wound phase；Use the anti-sense of the foam dressing of ultrasonic wave dipping method acquisition
The effect of dye rate and promotion healing is all more satisfactory.
Above-mentioned embodiment is only the preferred embodiment of the present invention, it is impossible to limit present invention protection with this
Scope, the change of any unsubstantiality that those skilled in the art is done on the basis of the present invention and replacement
Belong to scope of the present invention.
Claims (10)
1. the foam dressing of the anti-biotic material of zinc containing composite silver, it is characterised in that: this foam dressing includes gathering
Urethane foamed plastics and the composite silver zinc anti-biotic material being attached in polyurethane foam plastics；
Described composite silver zinc anti-biotic material includes Nano Silver, Nano-Zinc and nano inorganic carrier, with percent mass
Being 10-20% than the effective content of meter silver, the effective content of zinc is 20-40%, balance of nano inorganic carrier；
One of method of foam dressing of the described anti-biotic material of zinc containing composite silver of preparation, comprises the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate and the step 1 of 1.0-2.0 weight portion) described composite silver zinc is antibacterial
Material mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute, and obtain containing anti-biotic material is thick
Performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, the mixing of 0.8-2.6 weight portion water, stir rapidly, add to step 2) institute
State thick performed polymer, immediately high-speed stirred, pour rapidly foaming mould foaming after mixing into, cure 24-28
The foam dressing of the anti-biotic material of zinc containing composite silver is i.e. obtained after little Shi；
Or the two of the method for the foam dressing of the described anti-biotic material of zinc containing composite silver of preparation, comprise the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute,
Obtain thick performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight portion water and 1.0-2.0 weight portion step 1) described composite silver zinc
Anti-biotic material mixes, and stirs rapidly, adds to step 2) described thick performed polymer, high-speed stirred immediately,
Pour rapidly foaming mould foaming after mixing into, after curing 24-28 hour, i.e. obtain the anti-biotic material of zinc containing composite silver
Foam dressing；
Or the three of the method for the foam dressing of the described anti-biotic material of zinc containing composite silver of preparation, comprise the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare foamed plastics: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
The ratio mixing of 25.0-35.0 parts by weight of toluene diisocyanate, heating stirring, 80-85 DEG C of insulation reaction 80-120
Minute, take 10.0-20.0 weight portion PPG, 0.5-1.5 parts by weight of octanoic acid stannous, 0.5-1.4 weight portion two
Methylethanolamine, 0.5-1.8 weight portion silicon surface active agent, 0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight
Part water mixing, high-speed stirred immediately, pour rapidly foaming mould foaming after mixing into, cure 24-28 hour
Obtain foamed plastics；
3) preparation of the foam dressing containing anti-biotic material: by 90-95 parts per weight dispersing agent, 2.0-4.0 weight portion again
Closing silver zinc anti-biotic material, the mixing of 1.0-7.0 weight portion suspending agent, stir to obtain composite silver zinc anti-biotic material outstanding
Turbid liquid, by step 2) described foamed plastics immerses this suspension, with the frequency effect 2-5min of 28-40Hz,
It is dried, the foam dressing of composite silver zinc anti-biotic material must be contained.
2. the foam dressing of the anti-biotic material of zinc containing composite silver according to claim 1, it is characterised in that: institute
The raw material stating Nano Silver is selected from nano level Ag2O、Ag2O2、Ag2CO3、Ag2C2H3O3And Ag2SO4In
One or more.
3. the foam dressing of the anti-biotic material of zinc containing composite silver according to claim 1, it is characterised in that: institute
The raw material stating Nano-Zinc is selected from nano level ZnSO4、Zn(C2H3O2)2、ZnO、ZnCO3、Zn(OH)2、
ZnSO4·6H2O and Zn (C2H3O2)2·6H2One or more in O.
4. the foam dressing of the anti-biotic material of zinc containing composite silver according to claim 1, it is characterised in that: institute
State nano inorganic carrier selected from nano level calcium carbonate, hydrotalcite, titanium dioxide, bentonite, diatomite,
One or more in sepiolite, kaolin.
5. the foam dressing of the anti-biotic material of zinc containing composite silver according to claim 1, it is characterised in that: institute
The surface stating foam dressing is also covered with the hypothallus of tack, separator paper layer, a kind of or two in hydrocolloid layer
More than Zhong.
6. the method preparing the foam dressing of the anti-biotic material of zinc containing composite silver described in any one of claim 1-5, bag
Include following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate and the step 1 of 1.0-2.0 weight portion) described composite silver zinc is antibacterial
Material mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute, and obtain containing anti-biotic material is thick
Performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, the mixing of 0.8-2.6 weight portion water, stir rapidly, add to step 2) institute
State thick performed polymer, immediately high-speed stirred, pour rapidly foaming mould foaming after mixing into, cure 24-28
The foam dressing of the anti-biotic material of zinc containing composite silver is i.e. obtained after little Shi.
7. the method preparing the foam dressing of the anti-biotic material of zinc containing composite silver described in any one of claim 1-5,
Comprise the following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare performed polymer: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
25.0-35.0 parts by weight of toluene diisocyanate mixes, heating stirring, 80-85 DEG C of insulation reaction 80-120 minute,
Obtain thick performed polymer；
3) preparation of the foam dressing containing anti-biotic material: take 10.0-20.0 weight portion PPG, 0.5-1.5
Parts by weight of octanoic acid stannous, 0.5-1.4 weight portion dimethylethanolamine, 0.5-1.8 weight portion silicon surface active agent,
0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight portion water and 1.0-2.0 weight portion step 1) described composite silver zinc
Anti-biotic material mixes, and stirs rapidly, adds to step 2) described thick performed polymer, high-speed stirred immediately,
Pour rapidly foaming mould foaming after mixing into, after curing 24-28 hour, i.e. obtain the anti-biotic material of zinc containing composite silver
Foam dressing.
8. the method preparing the foam dressing of the anti-biotic material of zinc containing composite silver described in any one of claim 1-5, bag
Include following steps:
1) composite silver zinc anti-biotic material is prepared；
2) prepare foamed plastics: take 40.0-53.0 weight portion dehydration polyethylene glycol, 1.5-3.0 parts by weight of glycerin,
The ratio mixing of 25.0-35.0 parts by weight of toluene diisocyanate, heating stirring, 80-85 DEG C of insulation reaction 80-120
Minute, take 10.0-20.0 weight portion PPG, 0.5-1.5 parts by weight of octanoic acid stannous, 0.5-1.4 weight portion two
Methylethanolamine, 0.5-1.8 weight portion silicon surface active agent, 0.5-1.6 weight parts Methylene chloride, 0.8-2.6 weight
Part water mixing, high-speed stirred immediately, pour rapidly foaming mould foaming after mixing into, cure 24-28 hour
Obtain foamed plastics；
3) preparation of the foam dressing containing anti-biotic material: by 90-95 parts per weight dispersing agent, 2.0-4.0 weight portion again
Closing silver zinc anti-biotic material, the mixing of 1.0-7.0 weight portion suspending agent, stir to obtain composite silver zinc anti-biotic material outstanding
Turbid liquid, by step 2) described foamed plastics immerses this suspension, with the frequency effect 2-5min of 28-40Hz,
It is dried, the foam dressing of composite silver zinc anti-biotic material must be contained.
9. method as claimed in claim 8, it is characterised in that:
Described dispersant is purified water or ethanol；
Described suspending agent selected from cataloid, CMC, sodium alginate, CMC-Na one or more.
10. the method as described in any one of claim 6-9, it is characterised in that described containing anti-biotic material
The surface of foam dressing also covers one or both in the hypothallus of tack, separator paper layer or hydrocolloid layer
Above.
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| CN106139226A (en) * | 2016-08-30 | 2016-11-23 | 苏州美迪斯医疗运动用品股份有限公司 | A kind of medical sponge and preparation method thereof |
| CN106492266B (en) * | 2016-10-14 | 2019-08-06 | 湖北大学 | A kind of surface has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation method |
| CN106581739A (en) * | 2016-11-22 | 2017-04-26 | 唐林元 | Preparation method of composite absorbable protein-type non-sticky foam dressing |
| CN106832206A (en) * | 2017-01-20 | 2017-06-13 | 中国科学院长春应用化学研究所 | A kind of medical dressing material with cooling capacity and preparation method thereof |
| CN107185030A (en) * | 2017-04-25 | 2017-09-22 | 哈尔滨工程大学 | A kind of high adsorption foam dressing and preparation method thereof |
| CN108014362A (en) * | 2018-02-07 | 2018-05-11 | 苏州元禾医疗器械有限公司 | A kind of preparation method of the wound dressing of dispeling scar |
| CN108030950A (en) * | 2018-02-07 | 2018-05-15 | 苏州元禾医疗器械有限公司 | A kind of wound dressing of dispeling scar |
| CN109289085B (en) * | 2018-11-09 | 2021-02-02 | 广东体达康医疗科技有限公司 | Novel method for preparing hydrophilic polyurethane silver ion dressing |
| CN109432481A (en) * | 2018-12-06 | 2019-03-08 | 广州润虹医药科技股份有限公司 | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof |
| CN110433321A (en) * | 2019-07-06 | 2019-11-12 | 张明 | A kind of preparation method of the medical foam dressing with sustained-release antibacterial |
| CN112370565A (en) * | 2020-11-27 | 2021-02-19 | 河南汇博医疗股份有限公司 | Silver-containing long-acting antibacterial dressing |
| CN115678097A (en) * | 2022-10-11 | 2023-02-03 | 中山欣必康生物科技有限公司 | Medical high-absorption polyurethane foam dressing and preparation method thereof |
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| ES2358684T3 (en) * | 2007-03-01 | 2011-05-12 | Mölnlycke Health Care Ab | FOAM STRUCTURE CONTAINING SILVER. |
| WO2008156285A1 (en) * | 2007-06-21 | 2008-12-24 | Wonbiogen Co., Ltd. | Method for producing hydrophilic foam dressing and hydrophilic foam dressing produced thereby |
| CN102210325B (en) * | 2011-01-27 | 2013-11-06 | 深圳市源兴纳米医药科技有限公司 | Composite antibacterial powder and preparation method thereof |
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Address after: 518000 Nanshan High-tech Industrial Park, Shenzhen City, Guangdong Province, No. 1 North Songpingshan Road, North Ring Road, No. 10 Floor 001, South Block of Yuanxing Science and Technology Building Patentee after: Shenzhen Yuanxing pharmaceutical Limited by Share Ltd Address before: Room 1001, South Block, Yuanxing Science and Technology Building, No. 1 Songpingshan Road, North District, Nanshan Science and Technology Park, Shenzhen City, Guangdong Province, 518057 Patentee before: Shenzhen Yuanxing Nano-Pharmaceutical Co., Ltd. |