CN106492266B - A kind of surface has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation method - Google Patents
A kind of surface has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The present invention relates to a kind of surfaces to have antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation method, to prepare the hydrogel antimicrobial dressing with good antibiotic property.The second object of the present invention is to have the hydrogel carrier in uniform aperture with dissolution-regeneration method preparation.The third object of the present invention is to be impregnated in the hydrogel of synthesis in certain density silver nitrate solution with ultraviolet light, Ag ion is reduced to the small Nano silver grain of partial size in situ to be evenly distributed in hydrogel, the generation of the Nano silver grain catalysis oxidation zinc nanometer rods obtained simultaneously, so that nano silver and oxidation zinc bar is played Synergistic biocidal effect on the hydrogel, improves the anti-microbial property of hydrogel.
Description
Technical field
The present invention relates to a kind of preparation methods of aerogel dressing, especially a kind of to have antibacterial surface nano silver/oxygen
Change the preparation method of zinc composite hydrogel dressing.
Background technique
Bio-medical material is the basis for studying artificial organs and medical instrument, for being diagnosed, being treated to organism
Illness, surgical repair replace its disease damage tissue, organ or promote its function, and will not generate dysgenic material to organism
Material.As bio-medical material, it should be property nontoxic to the human body, without sensitization, nonirritant, hereditary-less toxicity and non-carcinogenesis
Equal adverse reactions.
Cellulose is the most abundant renewable natural organic polymeric materials in nature, due to its superior structure and performance
It is widely noticed.But cellulose solubility in most of solvents is low to cause its use to be restricted, however, with cellulose solvent
Such as the research and development of sodium hydroxide, cellulose are more and more by the most common dissolution-regeneration method conduct
Raw material are applied in the synthesis of hydrogel.
Surgical operation, high temperature, skin injury caused by radiation and chemical reagent etc. will lead to by microorganism especially large intestine
Bacterium infection caused by bacillus and staphylococcus aureus.In in the past few years, the treatment of this wound and burn is caused extensively
The healing of general concern, this wound needs a wet environment.Hydrogel is three-dimensional net structure, has good biology
Compatibility and hydrophilic a kind of high molecular material, can be swollen ten to thousands of times in water environment.Therefore hydrogel can be made
For antibacterial agent carrier and regeneration can be promoted, be the fester that can be absorbed due to it in wound and kill in wound
Bacterium promote the healing of wound.Therefore, researchers start to change hydrogel with some organic and inorganic antiseptic
Property enhances its antibiotic property.However, inorganic antiseptic has attracted more concerns, because they are poor compared to stability, due to
Abuse of antibiotics and caused by bacterial drug resistance organic antibacterial agent, have powerful and lasting anti-microbial property and safety.
In order to obtain with the hydrogel antimicrobial dressing of good antibiotic property, we are by the method for ultraviolet reduction by hydrogel
In the Ag that is combined with-COO-+It is reduced into nanoscale, uniform particle diameter and evenly dispersed Nano silver grain.However nanometer silver granuel
To gram-positive bacteria, for example staphylococcus aureus shows lower antibacterial effect to son.For this purpose, we by with alkali by water
The Zn combined in gel with-COO-2+Precipitate into the zinc oxide nano rod of nanoscale, staphylococcus aureus to zinc oxide very
It is sensitive.
Further, since silver can improve photocatalytic activity related with zinc oxide antibacterial, then compared to simple zinc oxide
The antibiotic property of the hybrid systems of antibacterial, zinc oxide and silver can significantly improve.
Chinese patent 201510770130.8 discloses a kind of antibiotic property hydrogel composite material and preparation method thereof, described
Hydrogel material be using chitosan as alkaline polysaccharide.Specific: under acidic environment, the chemical conversion of chitosan side chain protons is poly-
Cationic polyelectrolyte can form uniform hydrogel by electrostatic interaction, recycle the swelling action of hydrogel, so that
With the silver ion uniform adsorption in the evenly dispersed good silver nitrate of stabilizer in hydrogel reticular structure, reducing agent is utilized
NaBH4, fabricated in situ nano silver particles on the hydrogel.Advantage is: obtained hydrogel composite material nano silver partial size
It is small, and be uniformly distributed it is not easy to reunite, thus have strong anti-microbial property.
Summary of the invention
The purpose of the present invention is to provide a kind of surfaces to have antibacterial nano-silver, zinc oxide composite hydrogel dressing, this
Invention additionally provides a kind of preparation method of composite hydrogel dressing.
A kind of surface has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation method, includes the following steps:
It is 3-5%, parts by weight 20-35 that S1, the carboxymethyl cellulose for being 20-35 by parts by weight, which are dissolved in mass volume ratio,
NaOH solution in and mechanical stirring 30-50 minutes, then by parts by weight be 50-90 epoxychloropropane be slowly dropped into it is above-mentioned
In mixed liquor and mechanical stirring 2-6 hours；
S2, above-mentioned mixed liquor is slowly injected into glass container and is placed in baking oven, prepolymerization 2-3 is small at 60-80 DEG C
When performed polymer is made, then performed polymer is cleaned with deionized water and is placed in baking oven afterwards several times, it is small that 18-30 is polymerize at 50-60 DEG C
When be made carboxymethyl cellulose hydrogel；
S3, obtained hydrogel is cut into sequin, is placed in deionized water 10-12 hours, is immersed in after taking-up dense
It is placed within 10-12 hours under ultraviolet lamp and irradiates 2-5 hours in the silver nitrate solution that degree is 1.25mM, loading nano silvery particle is made
Hydrogel；
S4, the hydrogel for the loading nano silvery particle that S3 is obtained is immersed in 10-12 in the zinc nitrate solution that concentration is 5mM
Hour, then be soaked in sodium hydroxide solution after 2-5 hours and clean up after above-mentioned hydrogel is cleaned, obtain nano silver/
Zinc oxide composite hydrogel.
Epoxychloropropane is slowly dropped into above-mentioned mixed liquor with constant pressure funnel in step S1, the glass container
For the glass dish of diameter 15cm, obtained hydrogel is cut into sequin with mold；The preferred concentration quality of NaOH solution in S1
Volume ratio is 3%；The mixing time that carboxymethyl cellulose is dissolved described in S1 is 30 minutes；It is dried when prepolymerization described in step 1
Box temperature degree is set as 80 DEG C；Ultraviolet lamp irradiation time described in step S3 is 2 hours；It is impregnated in silver nitrate described in step S3
Time is 12 hours；Soaking time is 12 hours in zinc nitrate described in step S4.
A kind of surface of the present invention has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation method,
The comparison prior art has the advantages that
(1) nano silver is prepared using ultraviolet reduction and with alkali precipitation zinc oxide nano rod, be not required to heat while also not have
Evil gas generates, economic and environment-friendly；
(2) since silver can improve photocatalytic activity related with zinc oxide antibacterial, zinc oxide is anti-with the hybrid systems of silver
Bacterium property can significantly improve；
(3) preparation method is simple, and equipment investment is few, and consumption resource is few, and enforcement difficulty is small；
(4) hydrogel antimicrobial dressing prepared by has good antibiotic property, and the aperture of hydrogel carrier is uniform；
(5) that the Ag ion in silver nitrate solution is reduced to the small Nano silver grain of partial size in situ by ultraviolet light is equal
It is even to be distributed in hydrogel, while the generation of obtained Nano silver grain catalysis oxidation zinc nanometer rods, make nano silver and zinc oxide
Stick plays Synergistic biocidal effect on the hydrogel, improves the anti-microbial property of hydrogel.
Detailed description of the invention
Fig. 1 is the SEM figure of composite hydrogel in embodiment 1；
Fig. 2 is ratio chart of the different antibiotic property composite hydrogels to Escherichia coli and staphylococcus aureus antibiotic rate.
Specific embodiment
Hydrogel of the present invention is described further with reference to the accompanying drawings and examples, but the present invention claims guarantors
The range of shield is not limited to range described in embodiment.
Embodiment 1:
(1) in the NaOH solution for the 3%W/V that 3g carboxymethyl cellulose (CMC) is dissolved in 100mL and mechanical stirring
Then the epoxychloropropane of 6mL is slowly dropped into above-mentioned mixed liquor and mechanical stirring 2h by 30min with constant pressure funnel,
And then mixed liquor is slowly injected into the glass dish that diameter is 15cm and is placed in baking oven, prepolymerization 2h at 80 DEG C, then will
Performed polymer is cleaned with deionized water and is placed in baking oven afterwards several times, polymerize at 50 DEG C and carboxymethyl cellulose hydrogel circle is made for 24 hours
Piece；
(2) hydrogel disks that step 1 obtains sequin (diameter 18mm, thickness 1.5mm) is cut into mold to be placed in
The hydrogel sequin of obtained swelling is immersed in the silver nitrate solution that 100mL concentration is 1.25mM by 12h in ionized water
12h, which is placed under ultraviolet lamp, irradiates 2h, and the hydrogel of loading nano silvery particle is made；
(3) by the hydrogel for the loading nano silvery particle that step 2 obtains be immersed in 100mL concentration be 5mM zinc nitrate it is molten
12h in liquid, then above-mentioned hydrogel is soaked in the sodium hydroxide solution that 100mL concentration is 0.01M clean up after 4h it is obtained
Nanometer silver/zinc oxide composite hydrogel.
Embodiment 2:
It (1) will be in the NaOH solution for the 3.5%W/V that 3.2g carboxymethyl cellulose (CMC) is dissolved in 100mL and machinery stirs
40min is mixed, is then slowly dropped into the epoxychloropropane of 5mL in above-mentioned mixed liquor and mechanical stirring with constant pressure funnel
3h.And then mixed liquor is slowly injected into the glass dish that diameter is 15cm and is placed in baking oven, prepolymerization 3h at 80 DEG C.Again
Performed polymer is cleaned with deionized water and is placed in baking oven afterwards several times, carboxymethyl cellulose hydrogel is made in polyase 13 0h at 60 DEG C
Disk；
(2) hydrogel disks that step 1 obtains sequin (diameter 18mm, thickness 1.5mm) is cut into mold to be placed in
The hydrogel sequin of obtained swelling is immersed in the silver nitrate solution that 100mL concentration is 0.75mM by 12h in ionized water
12h is placed under ultraviolet lamp and cleans up obtained nano silver composite hydrogel after irradiation 3h；
(3) hydrogel of obtained loading nano silvery particle is immersed in the zinc nitrate solution that concentration is 6mM 10 hours,
It is soaked in sodium hydroxide solution after 2 hours and cleans up after above-mentioned hydrogel is cleaned again, it is multiple to obtain nanometer silver/zinc oxide
Heshui gel.
Embodiment 3:
(1) 3.5g carboxymethyl cellulose (CMC) is dissolved in the NaOH solution that 100mL mass volume ratio is 4.5% simultaneously
And mechanical stirring 50min, then the epoxychloropropane of 8ml is slowly dropped into above-mentioned mixed liquor and machine with constant pressure funnel
Tool stirs 3h.And then mixed liquor is slowly injected into the glass dish that diameter is 15cm and is placed in baking oven, pre-polymerization at 55 DEG C
Close 4h.Performed polymer is cleaned with deionized water again and is placed in baking oven afterwards several times, 25h is polymerize at 60 DEG C, carboxymethyl cellulose is made
Hydrogel disks；
(2) above-mentioned mixed liquor is slowly injected into glass container and is placed in baking oven, is made within prepolymerization 3 hours at 75 DEG C
Performed polymer, then performed polymer is cleaned with deionized water and is placed in baking oven afterwards several times, 20 hours obtained carboxymethyls are polymerize at 50 DEG C
Cellulose aquagel；
(3) obtained hydrogel is cut into sequin, be placed in deionized water 12 hours, concentration is immersed in after taking-up is
It is placed within 10 hours in the silver nitrate solution of 3Mm/L under ultraviolet lamp and irradiates 3.5 hours, the water-setting of loading nano silvery particle is made
Glue；
(4) the hydrogel sequin of obtained swelling is immersed in 10h in the zinc nitrate solution that 100mL concentration is 5mM, then
Above-mentioned hydrogel is soaked in the sodium hydroxide solution that 100mL concentration is 0.01M after 4h and cleans up obtained nano zine oxide
Composite hydrogel.
Embodiment 4:
(1) by 2.5g carboxymethyl cellulose be dissolved in mass volume ratio be 3% NaOH solution in and mechanical stirring 35
Minute, then the epoxychloropropane of 6g is slowly dropped into above-mentioned mixed liquor and mechanical stirring 3.5 hours；
(2) above-mentioned mixed liquor is slowly injected into glass container and is placed in baking oven, is made within prepolymerization 2 hours at 60 DEG C
Performed polymer, then performed polymer is cleaned with deionized water and is placed in baking oven afterwards several times, 18 hours obtained carboxymethyls are polymerize at 50 DEG C
Cellulose aquagel；
(3) obtained hydrogel is cut into sequin, be placed in deionized water 10 hours, concentration is immersed in after taking-up is
It is placed within 10 hours in the silver nitrate solution of 0.75mM under ultraviolet lamp and irradiates 2.5 hours, the water-setting of loading nano silvery particle is made
Glue；
(4) hydrogel of obtained loading nano silvery particle is immersed in the zinc nitrate solution that concentration is 6mM 10 hours,
It is soaked in sodium hydroxide solution after 2.5 hours and cleans up after above-mentioned hydrogel is cleaned again, obtain a nanometer silver/zinc oxide
Composite hydrogel.
Embodiment 5:
(1) by 2.2g carboxymethyl cellulose be dissolved in mass volume ratio be 3.8% NaOH solution in and mechanical stirring
45 minutes, then the epoxychloropropane of 6.5g is slowly dropped into above-mentioned mixed liquor and mechanical stirring 3.5 hours；
(2) above-mentioned mixed liquor is slowly injected into glass container and is placed in baking oven, made within prepolymerization 2.5 hours at 75 DEG C
At performed polymer, then performed polymer is cleaned with deionized water and is placed in baking oven afterwards several times, 25 hours obtained carboxylic first are polymerize at 55 DEG C
Base cellulose aquagel；
(3) obtained hydrogel is cut into sequin, be placed in deionized water 10 hours, concentration is immersed in after taking-up is
It is placed within 10 hours in the silver nitrate solution of 3mM under ultraviolet lamp and irradiates 5 hours, the hydrogel of loading nano silvery particle is made；
(4) hydrogel of obtained loading nano silvery particle is immersed in 10 small in the zinc nitrate solution that concentration is 3.5mM
When, then be soaked in sodium hydroxide solution after 2.5 hours and clean up after above-mentioned hydrogel is cleaned, obtain nano silver/oxygen
Change zinc composite hydrogel.
Comparative example 1:
(1) step is the same as embodiment 1；
(2) obtained hydrogel is cut into sequin, be placed in deionized water 10 hours, concentration is immersed in after taking-up is
It is placed within 10 hours in the silver nitrate solution of 3mM under ultraviolet lamp and irradiates 5 hours, the hydrogel of loading nano silvery particle is made.
Comparative example 2:
(1) step is the same as embodiment 1；
(2) hydrogel disks that step 1 obtains sequin (diameter 18mm, thickness 1.5mm) is cut into mold to be placed in
It is small in the zinc nitrate solution of 5mM 10 to be immersed in 100mL concentration by 10h in ionized water for the hydrogel sequin of obtained swelling
When, then be soaked in sodium hydroxide solution after 2 hours and clean up after above-mentioned hydrogel is cleaned, obtain load Zinc oxide water
Gel.
Detailed description of the invention and measurement result: 1) Fig. 1 is the electron-microscope scanning figure of hydrogel made from embodiment 1, and scanning result is aobvious
Show, the zinc oxide is club shaped structure, and length is about 1um, and diameter shows it with good probably in 100nm or so
Composite performance.2) Fig. 2 is embodiment 1,2, and hydrogel obtained by comparative example 1,2 is anti-to Escherichia coli and staphylococcus aureus
The ratio chart of bacterium rate, the results show that resistance of the obtained hydrogel for Escherichia coli is verified, comparative example 1 reaches 80%, in fact
Applying example 1 is 76%, and comparative example 2 is 68%, and the effect of embodiment 2 is worst, is 64%.To staphylococcus aureus, embodiment 1 reaches
To 95%, followed by embodiment 2 and comparative example 2, reaching 92%, the effect of comparative example 1 is worst, and about 64%.
The measurement result analysis that correlation prepares product is carried out to composite hydrogel dressing obtained by above-described embodiment, it can be with
It obtains as follows:
(1) hydrogel obtained by above-described embodiment using ultraviolet reduction prepares nano silver and with alkali precipitation zinc-oxide nano
Stick is evenly distributed on water, and obtained composite hydrogel has excellent antibacterial effect；
(2) it is evenly distributed in hydrogel by alkali precipitation zinc oxide nano-particle, what is obtained under this situation is oxidation
Zinc nanoparticle rather than oxidation zinc bar, illustrate that silver has catalytic action to the formation of oxidation zinc bar really, but it is to large intestine bar
The antibacterial effect of bacterium seems general；
(3) nano silver is prepared using ultraviolet reduction and with alkali precipitation zinc oxide nano rod, be evenly distributed in hydrogel, institute
The length of oxidation zinc bar obtained is longer, and is easy to reunite, and illustrates that the amount of silver is influential on the oxidation length of zinc bar, and
Its antibacterial effect will be slightly poorer to the antibacterial of composite hydrogel.
It should be understood that these examples are only for illustrating the present invention and are not intended to limit the scope of the present invention.In addition, it should also be understood that,
After reading the content taught by the present invention, those skilled in the art can make various modifications or changes to the present invention, these
Equivalent form is also fallen within the scope of the appended claims of the present application.
Claims (10)
1. a kind of surface has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation method, which is characterized in that including
Following steps:
It is 3-5% that S1, the carboxymethyl cellulose for being 20-35 by parts by weight, which are dissolved in mass volume ratio, and parts by weight are 20-35's
In NaOH solution and mechanical stirring 30-50 minutes, then the epoxychloropropane that parts by weight are 50-90 is slowly dropped into above-mentioned mixed
Close liquid in and mechanical stirring 2-6 hours；
S2, above-mentioned mixed liquor is slowly injected into glass container and is placed in baking oven, made within prepolymerization 2-3 hours at 60-80 DEG C
At performed polymer, then performed polymer is cleaned with deionized water and is placed in baking oven afterwards several times, polymerize at 50-60 DEG C 18-30 hours and make
Obtain carboxymethyl cellulose hydrogel；
S3, obtained hydrogel is cut into sequin, be placed in deionized water 10-12 hours, concentration is immersed in after taking-up is
It is placed within 10-12 hours in the silver nitrate solution of 0.75-3mM under ultraviolet lamp and irradiates 2-5 hours, loading nano silvery particle is made
Hydrogel；
S4, the hydrogel for the loading nano silvery particle that S3 is obtained is immersed in concentration be 3-6mM zinc nitrate solution in 10-12 it is small
When, then be soaked in sodium hydroxide solution after 2-5 hours and clean up after above-mentioned hydrogel is cleaned, obtain nano silver/oxygen
Change zinc composite hydrogel.
2. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that epoxychloropropane is slowly dropped into above-mentioned mixed liquor with constant pressure funnel in step S1.
3. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that step S2 again and will be placed in baking oven after mixed liquor implantation glass container, and the glass container is
The glass dish of diameter 15cm.
4. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that obtained hydrogel is cut into sequin with mold.
5. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that the mass volume ratio concentration of NaOH solution is 3% in S1.
6. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that the mixing time that carboxymethyl cellulose is dissolved described in S1 is 30 minutes.
7. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that oven temperature is set as 80 DEG C when prepolymerization described in step 1.
8. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that ultraviolet lamp irradiation time described in step S3 is 2 hours.
9. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that soaking time is 12 hours in silver nitrate described in step S3.
10. a kind of surface according to claim 1 has antibacterial nano-silver/zinc oxide composite hydrogel dressing preparation
Method, which is characterized in that soaking time is 12 hours in zinc nitrate described in step S4.
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| CN106983907A (en) * | 2017-03-16 | 2017-07-28 | 湖北大学 | A kind of preparation method of the Ag/Ag AgCl/ZnO composite aquogel dressing of optical dynamic therapy skin trauma |
| CN108904466B (en) * | 2018-06-11 | 2020-08-25 | 太原理工大学 | Method for encapsulating insoluble drug by ZnO-containing hydrogel beads |
| CN109735154B (en) * | 2018-12-21 | 2021-08-27 | 天津西敦粉漆科技有限公司 | Long-acting antibacterial agent, long-acting antibacterial agent with immediate effect and preparation method thereof |
| CN111303453B (en) * | 2020-03-09 | 2021-06-04 | 中国海洋大学 | Preparation method and application of multiple sensitive hydrogel polymer |
| CN111643720A (en) * | 2020-06-24 | 2020-09-11 | 四川大学华西医院 | Hydrogel with antibacterial property for healing burn wound and preparation method thereof |
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