CN106492266A - A kind of surface has the preparation method of antibacterial nano-silver/zinc oxide composite aquogel dressing - Google Patents
A kind of surface has the preparation method of antibacterial nano-silver/zinc oxide composite aquogel dressing Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The present invention relates to a kind of surface has the preparation method of antibacterial nano-silver/zinc oxide composite aquogel dressing, in order to prepare the hydrogel antimicrobial dressing with good antibiotic property.The second object of the present invention is to prepare the hydrogel carrier with homogeneous aperture with dissolving regeneration method.The third object of the present invention is to impregnated in use in certain density silver nitrate solution ultraviolet light by the hydrogel of synthesis, Ag ions original position is reduced to the little Nano silver grain of particle diameter to be evenly distributed in hydrogel, the generation of the Nano silver grain catalysis oxidation zinc nanometer rods for obtaining simultaneously, make nanometer silver and oxidation zinc bar that Synergistic biocidal effect is played on hydrogel, improve the anti-microbial property of hydrogel.
Description
Technical field
The present invention relates to a kind of preparation method of aerogel dressing, particularly a kind of have antibacterial surface nanometer silver/oxygen
Change the preparation method of zinc composite aquogel dressing.
Background technology
Bio-medical material is the basis for studying artificial organ and medical apparatus and instruments, for organism is carried out diagnosing, treated
Illness, surgical repair are replaced its disease damage tissue, organ or promote its function, and will not produce dysgenic material to organism
Material.As bio-medical material, it should be to human body avirulence, without sensitization, nonirritant, hereditary-less toxicity and non-carcinogenesis
Deng untoward reaction.
Cellulose is most abundant renewable natural organic polymeric materials in nature, due to its superior structure and performance and
Extensively concerned.But cellulose dissolubility in most of solvents is low to cause which using being restricted, however, with cellulose solvent
Such as the research and development of sodium hydroxide, cellulose is more and more to be used as by modal dissolving-regeneration method
Raw material is applied in the synthesis of hydrogel.
Surgical operation, high temperature, the skin injury that radiation and chemical reagent etc. are caused can cause by microorganism especially large intestine
The bacterium infection that bacillus and staphylococcus aureuses are caused.In in the past few years, the treatment of this wound and burn is caused extensively
General concern, the healing of this wound need the environment of a moistening.Hydrogel is three-dimensional net structure, with good biology
The compatibility and hydrophilic family macromolecule material, can in water environment swelling ten to thousands of times.Therefore hydrogel can be made
Carrier for antibacterial and can promotion organization regeneration, be as it can absorb the puss in wound and kill in wound
Antibacterial promoting the healing of wound.Therefore, researchers start to change hydrogel with some organic and inorganic antiseptics
Property is strengthening its antibiotic property.However, inorganic antiseptic has attracted more concerns, because they are poor compared to stability, due to
Abuse of antibiotics and the organic antibacterial agent of bacterial drug resistance that causes, with powerful and lasting anti-microbial property and safety.
In order to obtain the hydrogel antimicrobial dressing with good antibiotic property, we are by the method for ultraviolet reduction by hydrogel
In the Ag that combined with-COO-+It is reduced into nanoscale, uniform particle diameter and homodisperse Nano silver grain.But nanometer silver granuel
To gram positive bacteria, for example staphylococcus aureuses show relatively low antibacterial effect to son.For this purpose, we pass through water with alkali
The Zn combined with-COO- in gel2+Precipitate into the zinc oxide nano rod of nanoscale, staphylococcus aureuses to zinc oxide very
Sensitive.Further, since silver can improve the photocatalytic activity relevant with zinc oxide antibacterial, then anti-compared to simple zinc oxide
The antibiotic property of the hybrid systems of bacterium, zinc oxide and silver can be significantly improved.
Chinese patent 201510770130.8 discloses a kind of antibiotic property hydrogel composite material and preparation method thereof, described
Hydrogel material be as alkaline polysaccharide using shitosan.Specifically：Under sour environment, the chemical conversion of shitosan side chain protons is poly-
Cationic polyelectrolyte, can form homogeneous hydrogel by electrostatic interaction, recycle the swelling action of hydrogel so that
With the silver ion uniform adsorption in the dispersed good silver nitrate of stabilizer in hydrogel network structure, using reducing agent
NaBH4, fabricated in situ nano silver particles on hydrogel.Advantage is：Obtained hydrogel composite material nanometer silver particle diameter
Little, and be uniformly distributed and be difficult to reunite, thus there is strong anti-microbial property.
Content of the invention
It is an object of the invention to provide a kind of surface has antibacterial nano-silver, zinc oxide composite aquogel dressing, this
Invention additionally provides a kind of preparation method of composite aquogel dressing.
A kind of surface has the preparation method of antibacterial nano-silver/zinc oxide composite aquogel dressing, comprises the steps：
S1, the carboxymethyl cellulose by weight portion for 20-35 are dissolved in mass volume ratio for 3-5%, and weight portion is 20-35's
In NaOH solution and mechanical agitation 30-50 minute, then by weight portion for 50-90 epoxychloropropane be slowly dropped into above-mentioned mixed
Close in liquid and mechanical agitation 2-6 hour；
S2, above-mentioned mixed liquor is slowly injected in glass container and is positioned in baking oven, prepolymerization 2-3 hour systems at 60-80 DEG C
Into performed polymer, then the cleaning of performed polymer deionized water is positioned in baking oven several times afterwards, be polymerized at 50-60 DEG C 18-30 hour systems
Obtain carboxymethyl cellulose hydrogel；
S3, the hydrogel for obtaining being cut into sequin, being placed in 10-12 hours in deionized water, concentration is immersed in after taking-up is
Irradiation 2-5 hours under uviol lamp are placed in the silver nitrate solution of 1.25mM after 10-12 hours, and the water of loading nano silvery particle is obtained
Gel；
It is little that S4, the hydrogel of the loading nano silvery particle for obtaining S3 are immersed in 10-12 in the zinc nitrate solution that concentration is 5mM
When, then will above-mentioned hydrogel clean after be soaked in sodium hydroxide solution and clean up after 2-5 hours, that is, nanometer silver/oxygen is obtained
Change zinc composite aquogel.
Epoxychloropropane is slowly dropped in above-mentioned mixed liquor with constant pressure funnel in step S1, described glass container
For the glass dish of diameter 15cm, the hydrogel mould for obtaining is cut into sequin；The preferred concentration quality of NaOH solution in S1
Volume ratio is 3%；The mixing time of the dissolving carboxymethyl cellulose described in S1 is 30 minutes；Dry during prepolymerization described in step one
Case temperature is set as 80 DEG C；The ultra violet lamp time described in step S3 is 2 hours；Soaking in zinc nitrate described in step S3
Time is 12 hours；Soak time in sodium hydroxide described in step S4 is 12 hours.
A kind of surface of the present invention has the preparation method of antibacterial nano-silver/zinc oxide composite aquogel dressing,
Contrast prior art has the advantage that：
(1) nanometer silver is prepared using ultraviolet reduction and use alkali precipitation zinc oxide nano rod, be not required to heating while not also being harmful to gas
Body is produced, economic and environment-friendly；
(2) as silver can improve the antibiotic property of the hybrid systems of the photocatalytic activity relevant with zinc oxide antibacterial, zinc oxide and silver
Can significantly improve；
(3) preparation method is simple, and equipment investment is few, and consumption resource is few, and enforcement difficulty is little；
(4) hydrogel antimicrobial dressing prepared by has good antibiotic property, and the aperture of hydrogel carrier is homogeneous；
(5) the Ag ions original position in silver nitrate solution is reduced to the little Nano silver grain of particle diameter by ultraviolet light uniformly to divide
Cloth is in hydrogel, while the generation of the Nano silver grain catalysis oxidation zinc nanometer rods for obtaining, makes nanometer silver and oxidation zinc bar exist
Synergistic biocidal effect is played on hydrogel, improves the anti-microbial property of hydrogel.
Description of the drawings
Fig. 1 is the SEM figures of composite aquogel in embodiment 1；
Fig. 2 is different antibiotic property composite aquogels to escherichia coli and the ratio chart of staphylococcus aureuses antibiotic rate.
Specific embodiment
With reference to the accompanying drawings and examples hydrogel of the present invention is described further, but application claims are protected
The scope of shield is not limited to the scope described in embodiment.
Embodiment 1：
(1) in the NaOH solution of the 3%W/V that 3g carboxymethyl celluloses (CMC) are dissolved in 100mL and mechanical agitation 30min,
Then the epoxychloropropane of 6mL is slowly dropped in above-mentioned mixed liquor and mechanical agitation 2h with constant pressure funnel, and then
Mixed liquor is slowly injected in the glass dish of a diameter of 15cm and is positioned in baking oven, prepolymerization 2h at 80 DEG C, then by performed polymer
Deionized water cleaning is positioned in baking oven several times afterwards, and at 50 DEG C, polymerization 24h is obtained carboxymethyl cellulose hydrogel disks；
(2) the hydrogel disks mould for obtaining step 1 is cut into sequin (diameter 18mm, thickness 1.5mm) and is placed in deionization
12h in water, the swelling hydrogel sequin for obtaining is immersed in the silver nitrate solution that 100mL concentration is 1.25mM after 12h
Irradiation 2h under uviol lamp is placed in, the hydrogel of loading nano silvery particle is obtained；
(3) hydrogel of the loading nano silvery particle for obtaining step 2 is immersed in the zinc nitrate solution that 100mL concentration is 5mM
12h, then above-mentioned hydrogel is soaked in the sodium hydroxide solution that 100mL concentration is 0.01M cleans up prepared nanometer after 4h
Silver/zinc oxide composite aquogel.
Embodiment 2：
(1) in the NaOH solution of the 3.5%W/V that 3.2g carboxymethyl celluloses (CMC) are dissolved in 100mL and mechanical agitation
Then the epoxychloropropane of 5mL is slowly dropped in above-mentioned mixed liquor and mechanical agitation 3h by 40min with constant pressure funnel.
And then mixed liquor is slowly injected in the glass dish of a diameter of 15cm and is positioned in baking oven, prepolymerization 3h at 80 DEG C.Again will
The cleaning of performed polymer deionized water is positioned in baking oven several times afterwards, and at 60 DEG C, polyase 13 0h is obtained carboxymethyl cellulose hydrogel circle
Piece；
(2) the hydrogel disks mould for obtaining step one is cut into sequin (diameter 18mm, thickness 1.5mm) and is placed in deionization
12h in water, the swelling hydrogel sequin for obtaining is immersed in the silver nitrate solution that 100mL concentration is 0.75mM after 12h
Be placed under uviol lamp prepared nano silver composite hydrogel is cleaned up after irradiation 3h；
(3) hydrogel of the loading nano silvery particle for obtaining is immersed in 10 hours in the zinc nitrate solution that concentration is 6mM, then will
Above-mentioned hydrogel is soaked in sodium hydroxide solution after cleaning and cleans up after 2 hours, that is, nanometer silver/zinc oxide Compound Water is obtained
Gel.
Embodiment 3：
(1) 3.5g carboxymethyl celluloses (CMC) are dissolved in the NaOH solution that 100mL mass volume ratios are 4.5% and machine
Tool stirs 50min, then the epoxychloropropane of 8ml is slowly dropped in above-mentioned mixed liquor with constant pressure funnel and machinery is stirred
Mix 3h.And then mixed liquor is slowly injected in the glass dish of a diameter of 15cm and is positioned in baking oven, prepolymerization 4h at 55 DEG C.
Again the cleaning of performed polymer deionized water is positioned in baking oven several times afterwards, at 60 DEG C, polymerization 25h is obtained carboxymethyl cellulose water-setting
Glue disk；
(2) above-mentioned mixed liquor is slowly injected in glass container and is positioned in baking oven, prepolymerization at 75 DEG C makes pre-polymerization in 3 hours
Body, then the cleaning of performed polymer deionized water is positioned in baking oven several times afterwards, be polymerized at 50 DEG C 20 hours prepared carboxymethyl celluloses
Hydrogel；
(3) hydrogel for obtaining being cut into sequin, being placed in 12 hours in deionized water, concentration is immersed in after taking-up for 3Mm/
It is placed in after 10 hours in the silver nitrate solution of L under uviol lamp and irradiates 3.5 hours, the hydrogel of loading nano silvery particle is obtained；
(4) the swelling hydrogel sequin for obtaining is immersed in 10h in the zinc nitrate solution that 100mL concentration is 5mM, then will be upper
Stating hydrogel and being soaked in prepared nano zine oxide is cleaned up after 4h in the sodium hydroxide solution that 100mL concentration is 0.01M be combined
Hydrogel.
Embodiment 4：
(1) 2.5g carboxymethyl celluloses are dissolved in the NaOH solution that mass volume ratio is 3% and mechanical agitation 35 minutes,
Then the epoxychloropropane of 6g is slowly dropped in above-mentioned mixed liquor and mechanical agitation 3.5 hours；
(2) above-mentioned mixed liquor is slowly injected in glass container and is positioned in baking oven, prepolymerization at 60 DEG C makes pre-polymerization in 2 hours
Body, then the cleaning of performed polymer deionized water is positioned in baking oven several times afterwards, be polymerized at 50 DEG C 18 hours prepared carboxymethyl celluloses
Hydrogel；
(3) hydrogel for obtaining being cut into sequin, being placed in 10 hours in deionized water, concentration is immersed in after taking-up is
It is placed in after 10 hours in the silver nitrate solution of 0.75mM under uviol lamp and irradiates 2.5 hours, the water-setting of loading nano silvery particle is obtained
Glue；
(4) hydrogel of the loading nano silvery particle for obtaining is immersed in 10 hours in the zinc nitrate solution that concentration is 6mM, then will
Above-mentioned hydrogel is soaked in sodium hydroxide solution after cleaning and cleans up after 2.5 hours, that is, nanometer silver/zinc oxide is obtained and is combined
Hydrogel.
Embodiment 5：
(1) 2.2g carboxymethyl celluloses are dissolved in the NaOH solution that mass volume ratio is 3.8% and 45 points of mechanical agitation
Then the epoxychloropropane of 6.5g is slowly dropped in above-mentioned mixed liquor and mechanical agitation 3.5 hours by clock；
(2) above-mentioned mixed liquor is slowly injected in glass container and is positioned in baking oven, prepolymerization at 75 DEG C is made pre- for 2.5 hours
Aggressiveness, then the cleaning of performed polymer deionized water is positioned in baking oven several times afterwards, the 25 hours prepared carboxymethyls that are polymerized at 55 DEG C are fine
Dimension hydrogel；
(3) hydrogel for obtaining being cut into sequin, being placed in 10 hours in deionized water, concentration is immersed in after taking-up for 3mM
Silver nitrate solution in be placed in after 10 hours under uviol lamp and irradiate 5 hours, the hydrogel of loading nano silvery particle is obtained；
(4) hydrogel of the loading nano silvery particle for obtaining is immersed in 10 hours in the zinc nitrate solution that concentration is 3.5mM, then
It is soaked in sodium hydroxide solution after above-mentioned hydrogel is cleaned and cleans up after 2.5 hours, that is, nanometer silver/zinc oxide is obtained multiple
Heshui gel.
Comparative example 1：
(1) step is with embodiment 1；
(2) hydrogel for obtaining being cut into sequin, being placed in 10 hours in deionized water, concentration is immersed in after taking-up for 3mM
Silver nitrate solution in be placed in after 10 hours under uviol lamp and irradiate 5 hours, the hydrogel of loading nano silvery particle is obtained.
Comparative example 2：
(1) step is with embodiment 1；
(2) the hydrogel disks mould for obtaining step one is cut into sequin (diameter 18mm, thickness 1.5mm) and is placed in deionization
10h in water, the swelling hydrogel sequin for obtaining is immersed in 10 hours in the zinc nitrate solution that 100mL concentration is 5mM, then
It is soaked in sodium hydroxide solution after above-mentioned hydrogel is cleaned and cleans up after 2 hours, that is, load Zinc oxide water gel is obtained.
Description of the drawings and measurement result：1) electron-microscope scanning figures of the Fig. 1 for hydrogel obtained in embodiment 1, scanning result show
Show, described zinc oxide is club shaped structure, length is about 1um, and diameter shows which has good probably in 100nm or so
Composite performance.2) Fig. 2 is embodiment 1,2, and the hydrogel obtained by comparative example 1,2 is anti-to escherichia coli and staphylococcus aureuses
The ratio chart of bacterium rate, as a result shows, obtained hydrogel is verified for colibacillary resistance, and comparative example 1 reaches 80%, in fact
It is 76% to apply example 1, and comparative example 2 is 68%, and the effect of embodiment 2 is worst, is 64%.To staphylococcus aureuses, embodiment 1 reaches
To 95%, next to that embodiment 2 and comparative example 2, reach 92%, the effect of comparative example 1 is worst, and about 64%.
The measurement result analysis that correlation prepares product is carried out to the composite aquogel dressing obtained by above-described embodiment, can be with
Draw as follows：
(1) hydrogel obtained by above-described embodiment prepares nanometer silver and equal with alkali precipitation zinc oxide nano rod using ultraviolet reduction
Even be distributed in water, obtained composite aquogel has excellent antibacterial effect；
(2) it is evenly distributed in hydrogel by alkali precipitation zinc oxide nano-particle, obtained under this situation is zinc oxide nano
Rice corpuscles rather than oxidation zinc bar, illustrate that silver has catalytic action to the formation for aoxidizing zinc bar really, but which are to colibacillary
Antibacterial effect seems general；
(3) nanometer silver is prepared using ultraviolet reduction and uses alkali precipitation zinc oxide nano rod, be evenly distributed in hydrogel, obtained
Oxidation zinc bar length longer, and easily reunite, illustrate that the amount of silver is influential on aoxidizing the length of zinc bar, and which resists
Bacterium effect will be slightly poorer to the antibacterial of composite aquogel.
It should be understood that these embodiments are only illustrative of the invention and is not intended to limit the scope of the invention.In addition, it is to be understood that
After the content for having read instruction of the present invention, those skilled in the art can be made various changes or modifications to the present invention, these
The equivalent form of value equally falls within the application appended claims limited range.
Claims (10)
1. a kind of surface has the preparation method of antibacterial nano-silver/zinc oxide composite aquogel dressing, it is characterised in that include
Following steps：
S1, the carboxymethyl cellulose by weight portion for 20-35 are dissolved in mass volume ratio for 3-5%, and weight portion is 20-35's
In NaOH solution and mechanical agitation 30-50 minute, then by weight portion for 50-90 epoxychloropropane be slowly dropped into above-mentioned mixed
Close in liquid and mechanical agitation 2-6 hour；
S2, above-mentioned mixed liquor is slowly injected in glass container and is positioned in baking oven, prepolymerization 2-3 hour systems at 60-80 DEG C
Into performed polymer, then the cleaning of performed polymer deionized water is positioned in baking oven several times afterwards, be polymerized at 50-60 DEG C 18-30 hour systems
Obtain carboxymethyl cellulose hydrogel；
S3, the hydrogel for obtaining being cut into sequin, being placed in 10-12 hours in deionized water, concentration is immersed in after taking-up is
Irradiation 2-5 hours under uviol lamp are placed in the silver nitrate solution of 0.75-3mM after 10-12 hours, and loading nano silvery particle is obtained
Hydrogel；
It is little that S4, the hydrogel of the loading nano silvery particle for obtaining S3 are immersed in 10-12 in the zinc nitrate solution that concentration is 3-6mM
When, then will above-mentioned hydrogel clean after be soaked in sodium hydroxide solution and clean up after 2-5 hours, that is, nanometer silver/oxygen is obtained
Change zinc composite aquogel.
2. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that epoxychloropropane is slowly dropped in above-mentioned mixed liquor with constant pressure funnel in step S1.
3. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that step S2 again and will be positioned in baking oven after mixed liquor implantation glass container, and described glass container is
The glass dish of diameter 15cm.
4. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that the hydrogel mould for obtaining is cut into sequin.
5. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that the mass volume ratio concentration of NaOH solution is 3% in S1.
6. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that the mixing time of the dissolving carboxymethyl cellulose described in S1 is 30 minutes.
7. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that oven temperature is set as 80 DEG C during prepolymerization described in step one.
8. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that the ultra violet lamp time described in step S3 is 2 hours.
9. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that the soak time in zinc nitrate described in step S3 is 12 hours.
10. a kind of surface according to claim 1 has the preparation of antibacterial nano-silver/zinc oxide composite aquogel dressing
Method, it is characterised in that the soak time in sodium hydroxide described in step S4 is 12 hours.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106983907A (en) * | 2017-03-16 | 2017-07-28 | 湖北大学 | A kind of preparation method of the Ag/Ag AgCl/ZnO composite aquogel dressing of optical dynamic therapy skin trauma |
| CN108904466A (en) * | 2018-06-11 | 2018-11-30 | 太原理工大学 | A method of the hydrogel beads containing ZnO encapsulate insoluble drug |
| CN109735154A (en) * | 2018-12-21 | 2019-05-10 | 天津西敦粉漆科技有限公司 | A kind of long-acting antibiotic agent, long-acting antibiotic agent with prompt effect and preparation method thereof |
| CN111303453A (en) * | 2020-03-09 | 2020-06-19 | 中国海洋大学 | Preparation method and application of multiple sensitive hydrogel polymer |
| CN111643720A (en) * | 2020-06-24 | 2020-09-11 | 四川大学华西医院 | Hydrogel with antibacterial property for healing burn wound and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1341358A (en) * | 2000-09-07 | 2002-03-27 | 刘建忠 | Silver zinc combined antimicrobial agent |
| CN1772311A (en) * | 2004-11-09 | 2006-05-17 | 深圳市清华源兴生物医药科技有限公司 | Wound dressing containing Ag-Zn composition |
| CN101445609A (en) * | 2008-11-14 | 2009-06-03 | 武汉大学 | Hydroscopic cellulose hydrogel and preparation method thereof |
| CN102114265A (en) * | 2011-02-23 | 2011-07-06 | 中国人民解放军军事医学科学院基础医学研究所 | Medical dressing containing nano silver and carboxymethyl chitosan and preparation method thereof |
| CN104667334A (en) * | 2015-03-24 | 2015-06-03 | 深圳市源兴纳米医药科技有限公司 | Foam dressing containing composite silver-zinc antibacterial material and preparation method of foam dressing |
| CN204655582U (en) * | 2015-05-18 | 2015-09-23 | 南阳市汇博生物技术有限公司 | The dressing of a kind of hydrogel antibacterial gauze |
-
2016
- 2016-10-14 CN CN201610898993.8A patent/CN106492266B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1341358A (en) * | 2000-09-07 | 2002-03-27 | 刘建忠 | Silver zinc combined antimicrobial agent |
| CN1772311A (en) * | 2004-11-09 | 2006-05-17 | 深圳市清华源兴生物医药科技有限公司 | Wound dressing containing Ag-Zn composition |
| CN101445609A (en) * | 2008-11-14 | 2009-06-03 | 武汉大学 | Hydroscopic cellulose hydrogel and preparation method thereof |
| CN102114265A (en) * | 2011-02-23 | 2011-07-06 | 中国人民解放军军事医学科学院基础医学研究所 | Medical dressing containing nano silver and carboxymethyl chitosan and preparation method thereof |
| CN104667334A (en) * | 2015-03-24 | 2015-06-03 | 深圳市源兴纳米医药科技有限公司 | Foam dressing containing composite silver-zinc antibacterial material and preparation method of foam dressing |
| CN204655582U (en) * | 2015-05-18 | 2015-09-23 | 南阳市汇博生物技术有限公司 | The dressing of a kind of hydrogel antibacterial gauze |
Non-Patent Citations (4)
| Title |
|---|
| ALI HEBEISH, ET AL.: "《Development of CMC hydrogels loaded with silver nano-particles for medical applications》", 《CARBOHYDRATE POLYMERS》 * |
| PING ZHU, ET AL.: "《Bionmedical Applications of Functionalized ZnO Nanomaterials: from Biosensors to Bioimaging》", 《ADV. MATER. INTERFACES》 * |
| 中国化学会高分子学科委员会: "《2005年全国高分子学术论文报告会》", 31 October 2005 * |
| 博士学位论文编辑部编著: "《2007年上海大学博士学位论文第1辑》", 30 September 2010, 上海：上海大学出版社 * |
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| CN106983907A (en) * | 2017-03-16 | 2017-07-28 | 湖北大学 | A kind of preparation method of the Ag/Ag AgCl/ZnO composite aquogel dressing of optical dynamic therapy skin trauma |
| CN108904466A (en) * | 2018-06-11 | 2018-11-30 | 太原理工大学 | A method of the hydrogel beads containing ZnO encapsulate insoluble drug |
| CN108904466B (en) * | 2018-06-11 | 2020-08-25 | 太原理工大学 | Method for encapsulating insoluble drug by ZnO-containing hydrogel beads |
| CN109735154A (en) * | 2018-12-21 | 2019-05-10 | 天津西敦粉漆科技有限公司 | A kind of long-acting antibiotic agent, long-acting antibiotic agent with prompt effect and preparation method thereof |
| CN109735154B (en) * | 2018-12-21 | 2021-08-27 | 天津西敦粉漆科技有限公司 | Long-acting antibacterial agent, long-acting antibacterial agent with immediate effect and preparation method thereof |
| CN111303453A (en) * | 2020-03-09 | 2020-06-19 | 中国海洋大学 | Preparation method and application of multiple sensitive hydrogel polymer |
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