CN107185030A - A kind of high adsorption foam dressing and preparation method thereof - Google Patents
A kind of high adsorption foam dressing and preparation method thereof Download PDFInfo
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- CN107185030A CN107185030A CN201710273680.8A CN201710273680A CN107185030A CN 107185030 A CN107185030 A CN 107185030A CN 201710273680 A CN201710273680 A CN 201710273680A CN 107185030 A CN107185030 A CN 107185030A
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- starch
- wound
- foam dressing
- high adsorption
- dressing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention is to provide a kind of high adsorption foam dressing and preparation method thereof.Mass fraction is constituted：Starch 10% 40%；Polyurethane prepolymer 26% 40%；Crosslinking agent 0.6% 1%；Chain extender 0.6 20%；Surfactant 1.4% 2%；Wetting agent 14% 20%；Foaming agent 18% 27%.The present invention is due to using starch for filler, make dressing that not only there is higher and faster water absorbing capacity, and starch can effectively pin the solute in sepage, while moist environment is provided for patient, the harmful substances such as the toxin and particulate in sepage are pinned, wound automatically cleaning effect is realized, reduced due to failing timely more change dressings, and the probability of wound infection is caused, cicatrize a wound faster.Its application includes partial thickness and full thickness wound, superficial wound, skin pressure ulcer, skin ulcer, leg ulcer, skin abrasion, diabetic ulcer, surgical drainage etc..
Description
Technical field
What the present invention was designed is a kind of preparation method of foam dressing, and specifically one kind can promote wound healing
Foam dressing preparation method.
Background technology
Common wound includes the acute injuries such as mechanical damage, burn in daily life, and due to poor circulation
Caused by the chronic wounds such as bedsore, ulcer.Some wound protracteds course of disease, considerable distress is brought to patient.
Wound healing is that body is related to histiocytic differentiation, migration, propagation and secretion by a variety of inflammatory cells
Growth factor, the repair process completed jointly by complicated coordinative role.Current polyurethane foam dressing is for wound
Sepage only has obvious absorbability, and the adsorption capacity to solute in sepage has no report.
The relevant report for the foam dressing for being loaded with starch or composite starch is had no at present, and with Adsorption of solute effect,
Wound self-cleaning function is played, the foam dressing that nutriment can also be provided for wound has no report.Therefore, exploitation can either
Sepage is absorbed faster and more, nutrition is provided for wound, and inflammatory factor, toxin and the particulate absorbed in sepage can be adsorbed again, is
Wound provides the healing environment for moistening and cleaning, the multifunctional foam dressing of wound healing can be promoted to have important clinical
Value.
The content of the invention
Moistening and clean environment can be provided for wound it is an object of the invention to provide one kind, nutrition is provided for wound
Promote the high adsorption foam dressing of wound healing.The present invention also aims to provide a kind of system of high adsorption foam dressing
Preparation Method.
The high adsorption foam dressing mass fraction of the present invention is constituted：Starch 10%-40%；Polyurethane prepolymer 26%-
40%；Crosslinking agent 0.6%-1%；Chain extender 0.6-20%；Surfactant 1.4%-2%；Wetting agent 14%-20%；Foaming
Agent 18%-27%.
The starch be a kind of plant amylum or its modified starch, or more than one plant amylum or its be modified form sediment
Powder uniformly mixes the composite starch of composition.
The plant amylum is that cornstarch, farina, starch from sweet potato, chestnut starch, rice starch or lotus rhizome form sediment
Powder.
The preparation method of high adsorption foam dressing of the present invention is：
(1) base polyurethane prepolymer for use as is prepared：35-50 parts of drying Hydrophilicrto polyether polyalcohol, 15-30 parts of two isocyanic acids
Ester, 0.5-3 parts of glycerine is well mixed heating stirring, and temperature range is 60 DEG C -85 DEG C, and the time is 2-4.5 hours, is gathered
Urethane performed polymer；
(2) starch is quickly uniformly mixed with crosslinking agent, chain extender, surfactant, foaming agent, wetting agent；
(3) mixture for obtaining step (2) is poured into base polyurethane prepolymer for use as, and is quickly uniformly mixed, and will be mixed
Thing is poured into mould and foamed, curing；
(4) dressing after curing is cut into regulatory specifications.
The rotating speed of quick stirring described in step (2) and (3) is 2000-4000rpm.
Described wetting agent is glycerine or propane diols.
Described base polyurethane prepolymer for use as is hydrophilic polyurethane performed polymer.
Described foaming includes using foaming agent foam or uses CO2Reactive blowing agent foaming.
Described foaming agent includes water, dichloromethane, n-hexane, pentane or Arcton 11.
Described crosslinking agent includes the polyethylene glycol that glycerine, molecular weight are 200-2000.
Described chain extender is 1,4 butanediols or ethylenediamine.
Described surfactant is the surfactant used in the conventional polyurethanes foam dressings such as F68, silicone oil.
Also include antiseptic, the antiseptic is poly (hexamethylene), triclosan, suppresses bacteroidal polysaccharide, eats
Oil or radix glycyrrhizae.
The starch includes starch artificial synthesized or that natural plants are derived from by various methods.
The invention provides a kind of foam dressing for being loaded with starch, the dressing can quick absorbing wound exudate, for wound
Mouth provides nutrition, promotes the tumor growth factor to assemble to wound, the solute in absorption sepage, provides moistening for wound and cleans
Environment, provides nutrition for wound and promotes wound healing.
Foam dressing proposed by the present invention with high Adsorption of solute can significantly and quickly absorb the diffusate of the surface of a wound,
Promote the tumor growth factor to assemble to wound, and there is very strong adsorption capacity to solute, this characteristic can not only be wound
Mouthful providing cleaning moist environment promotes healing, and can more reduce inflammatory factor and deposited to wound, forms scar.
The foam dressing with high adsorption of the present invention, which is applied, includes partial thickness and full thickness wound, superficial wound,
Skin pressure ulcer, skin ulcer, leg ulcer, skin abrasion, diabetic ulcer, surgical drainage.
A kind of preparation method for foam dressing with high Adsorption of solute that the present invention is provided is simple, and products obtained therefrom is easy to
Carry, and the excellent results of the present invention are also manifested by：
(1) foam dressing with high Adsorption of solute that the present invention is provided, stability is good, exquisite in texture, composition used
And process is nontoxic, product is non-stimulated to human body, with excellent biocompatibility；
(2) present invention makes to contain micro nutrition in dressing from filler of one or more starch as foam dressing
Element or the function of possessing certain specific starch, for example, cornstarch, water imbibition is high, containing micro mineral matter element and
Vitamin E, Lotus Root Starch has certain anastalsis.
(3) starch and polyurethane foam dressing are combined by the present invention, make dressing while being provided with starch and polyurethane foam
The excellent characteristics of foam dressing, can absorb wound exudate, moist environment is provided for wound, it is to avoid change the secondary wound of dressing belt
Evil, more effectively protects wound, promotes wound healing.
Brief description of the drawings
Fig. 1：Contrast case (left side) soaks 15h in same concentrations same volume dyestuff respectively with specific implementation case (right side)
Contrast afterwards.
Fig. 2：Dog hip bedsore paralyse using the agglutination after the foam dressing treatment of the high adsorption of the present invention.
Embodiment
Illustrate below and the present invention is described in more detail.
A kind of foam dressing with high adsorption, the dressing includes starch, polyurethane, crosslinking agent, surfactant etc..
Starch contained therein in dressing, content is the 10% of dressing mass fraction；Base polyurethane prepolymer for use as 40%；Crosslinking agent 1%；Table
Face activating agent 2%；Wetting agent 20%；Foaming agent 27%.
Base polyurethane prepolymer for use as is prepared first：The Hydrophilicrto polyether polyalcohol of 50 parts of drying, 15 parts of diisocyanate, 3
The glycerine of part is well mixed heating stirring, and temperature is 80 DEG C, and the time is 2.5 hours, obtains performed polymer；By starch and crosslinking agent,
Surfactant, foaming agent, wetting agent etc. are quickly uniformly mixed；Well mixed additive is poured into performed polymer, and
Quickly it is uniformly mixed, rotating speed is 4000rpm, pours the mixture into mould and foam, curing；By the dressing cutting after curing
Into regulatory specifications.
The starch is to include cornstarch, farina, starch from sweet potato, chestnut starch, rice starch, Lotus Root Starch
Etc. the one or more composite starch mixed uniformly by a certain percentage including various plant amylums or its modified starch；Institute
State each content of starch scope in starch, cornstarch (0~50 part), farina (0~50 part), starch from sweet potato (0~50
Part), chestnut starch (0~50 part), rice starch (0~50 part), Lotus Root Starch (0~50 part)；Wetting agent used includes the third three
Alcohol, propane diols etc.；Base polyurethane prepolymer for use as is any hydrophilic polyurethane performed polymer；Foam pattern used is included using foaming agent hair
Steep and use CO2Deng the foam pattern of reactive blowing agent；Foaming agent used includes water, dichloromethane, n-hexane, pentane, trichlorine
One kind in the Traditional blowing agents such as fluoromethane；Crosslinking agent used includes the polyethylene glycol that glycerine, molecular weight are 200-2000；Institute
It is the one or more in the amines such as 1,4 butanediols, ethylenediamine with chain extender；Surfactant used is that F68, silicone oil etc. are conventional
Surfactant used in polyurethane foam dressing；The antiseptic includes poly (hexamethylene), triclosan, suppresses bacillary
The Chinese medicine such as polysaccharide, edible oil or radix glycyrrhizae；There is the foam dressing of high adsorption, which to apply, for this includes partial thickness and full cortex
Wound, superficial wound, skin pressure ulcer, skin ulcer, leg ulcer, skin abrasion, diabetic ulcer, surgical drainage
Deng；The starch includes starch artificial synthesized or that natural plants are derived from by various methods.
Sepage absorbent properties are tested
Water absorption rate, absorption rate, the test of vertical wicking performance have been carried out to case study on implementation, this hair is illustrated with this
The bright absorbent properties to sepage.
Water absorption rate test：The foam dressing of case study on implementation is cut into 3cm*3cm*0.5cm specification, initial weight (A) is weighed
Afterwards, by sample at room temperature as in distilled water, after immersion 24h, extracted from distilled water, with the moisture of blotting paper adsorption surface,
Weigh (B), and water absorption rate calculation formula is：
Water absorption rate (%)=(B-A)/A*100
Absorption rate is tested：Using suction pipe by after water droplet to sample surfaces, test water is fully entrained sample interior institute's used time
Between.The process is operated 10 times repeatedly in sample surfaces different parts, is averaged, is produced absorption rate.
Vertical wicking performance test：The performance can characterize dressing pair and absorb wound point with gravity direction opposite direction
The ability of bleeding.
The specific specification that the foam dressing of case study on implementation is cut into 2cm*20cm*0.8cm, at room temperature immerses sample
Foam sample is determined in distilled water containing dyestuff and absorbs water to the time used in water surface 3cm, the process is operated 5 times, is averaged repeatedly
Value, as vertical wicking speed.
What the sample that vertical capillary absorption capacity then determines same size was reached at room temperature reaches absorption maximum height.
Case sepage absorbent properties test result explanation is embodied：
Absorption rate：0.98 second
Water absorption rate：1000%
Vertical wicking speed：2 points 10 seconds (lifting height is apart from liquid level 6cm at 15 minutes)
Vertical capillary absorption capacity：9cm
Vertical capillary absorption capacity be it is a kind of can show that to transmit the standard of measuring of juice with gravity opposite direction, and
The index of vertical wicking performance mainly includes vertical wicking speed and vertical capillary absorption capacity.
Sample is entered by specific implementation case at room temperature in the present invention foam sample is determined in the distilled water containing dyestuff
Product absorb water to water surface 3cm used in the time, as a result represent, specific implementation case in foam sample absorb water to apart from liquid level 3cm when institutes
With the time be 2 points 10 seconds, and sample lower end is immersed in containing in the bromocresol green aqueous solution always, is placed after 15h, solution such as Fig. 1
It is shown.
Fig. 1 results show that the bromocresol green solution colour for soaking the polyurethane foam dressing of specific implementation case is obvious
Thin out, the foam dressing of this explanation present invention has very strong suction-operated, and foam of the present invention to the material in the aqueous solution
The vertical capillary absorption rate of dressing is also higher, it is possible thereby to infer that the present invention has more compared to the foam dressing of same type
Strong vertical capillary absorption capacity and the adsorption capacity to solute in sepage.
Results of animal explanation
Influence of the foam dressing of the present invention to bedsore in beasle dog acute spinal cord injury model.Female beagle dogs,
Body weight 7kg.After general anesthesia, prone position is taken, fixing limbs centered on T9-10, do ridge Posterior midline approach, cut successively, cruelly
Reveal spinal cord, from T9 horizontal cross-sectional spinal cords, successively closing wound.Twice, massage urination defecation is twice for postoperative daily feeding.
The postoperative forelimb standing hind limb paralysis of beasle dog acute spinal cord injury, forms cotton-padded mattress at art one week after bilateral ischial tuberosity
Sore, left side is larger, diameter about 4.5cm, depth about 1cm, the reaction of periphery mild inflammation and surface necrotic area, and right side depth is relatively deeply about
2cm, forms the visible ischial tuberosity of sinus, sore face diameter about 3cm.The surface of a wound 2 weeks is applied with gauze, bedsore continuing advances can be used as pair
According to process.
Then foam dressing covering open sore part surface of the present invention, is fixed with gauze bandage, changed daily, such as application
It is impregnated with and is changed in time.Process photo is shown in Fig. 2, it is seen that processing in 3 days is shown in that fresh granulation occurs；Processing 20 days, sinus healing,
The open sore part is concordant with surrounding, and sore face substantially diminishes and dried without secretion, basic healing.
Claims (5)
1. a kind of high adsorption foam dressing, it is characterized in that mass fraction composition is：Starch 10%-40%；Polyurethane prepolymer
26%-40%；Crosslinking agent 0.6%-1%；Chain extender 0.6-20%；Surfactant 1.4%-2%；Wetting agent 14%-20%；
Foaming agent 18%-27%.
2. high adsorption foam dressing according to claim 1, it is characterized in that：The starch be a kind of plant amylum or its
Modified starch, or more than one plant amylum or its modified starch uniformly mix the composite starch of composition.
3. high adsorption foam dressing according to claim 2, it is characterized in that：The plant amylum is cornstarch, horse
Bell sweet potato starch, starch from sweet potato, chestnut starch, rice starch or Lotus Root Starch.
4. a kind of preparation method of the high adsorption foam dressing described in claim 1, it is characterized in that：
(1) base polyurethane prepolymer for use as is prepared：35-50 parts of drying Hydrophilicrto polyether polyalcohol, 15-30 parts of diisocyanate,
0.5-3 parts of glycerine is well mixed heating stirring, and temperature range is 60 DEG C -85 DEG C, and the time is 2-4.5 hours, obtains polyurethane
Performed polymer；
(2) starch is quickly uniformly mixed with crosslinking agent, chain extender, surfactant, foaming agent, wetting agent；
(3) mixture for obtaining step (2) is poured into base polyurethane prepolymer for use as, and is quickly uniformly mixed, and mixture is fallen
Enter in mould and foam, curing；
(4) dressing after curing is cut into regulatory specifications.
5. the preparation method of high adsorption foam dressing according to claim 4, it is characterized in that：Institute in step (2) and (3)
The rotating speed for the quick stirring stated is 2000-4000rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710273680.8A CN107185030A (en) | 2017-04-25 | 2017-04-25 | A kind of high adsorption foam dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710273680.8A CN107185030A (en) | 2017-04-25 | 2017-04-25 | A kind of high adsorption foam dressing and preparation method thereof |
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| Publication Number | Publication Date |
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| CN107185030A true CN107185030A (en) | 2017-09-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710273680.8A Pending CN107185030A (en) | 2017-04-25 | 2017-04-25 | A kind of high adsorption foam dressing and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186197A (en) * | 2017-12-28 | 2018-06-22 | 河南汇博医疗股份有限公司 | A kind of complex function dressing for preventing and treating pressure sore and preparation method thereof |
| CN111748071A (en) * | 2020-06-29 | 2020-10-09 | 武汉瑞法医疗器械有限公司 | Hydrophilic polyurethane foam dressing and preparation method thereof |
| CN114588306A (en) * | 2022-03-04 | 2022-06-07 | 广东舒尔康生物科技有限公司 | High-absorption polyurethane foam and preparation method thereof |
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| CN1095075A (en) * | 1994-04-28 | 1994-11-16 | 上海华一经济科技实业公司 | High water absorbency plastic foam and preparation method |
| CN104225665A (en) * | 2014-09-30 | 2014-12-24 | 南阳市汇博生物技术有限公司 | Organic polyurethane foam dressing and preparation method thereof |
| CN104667334A (en) * | 2015-03-24 | 2015-06-03 | 深圳市源兴纳米医药科技有限公司 | Foam dressing containing composite silver-zinc antibacterial material and preparation method of foam dressing |
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2017
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|---|---|---|---|---|
| CN1095075A (en) * | 1994-04-28 | 1994-11-16 | 上海华一经济科技实业公司 | High water absorbency plastic foam and preparation method |
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| 郭金全等: "玉米淀粉对聚氨酯（PU）泡沫化学改性的研究", 《厦门大学学报（自然科学版）》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108186197A (en) * | 2017-12-28 | 2018-06-22 | 河南汇博医疗股份有限公司 | A kind of complex function dressing for preventing and treating pressure sore and preparation method thereof |
| CN111748071A (en) * | 2020-06-29 | 2020-10-09 | 武汉瑞法医疗器械有限公司 | Hydrophilic polyurethane foam dressing and preparation method thereof |
| CN111748071B (en) * | 2020-06-29 | 2022-03-01 | 武汉瑞法医疗器械有限公司 | Hydrophilic polyurethane foam dressing and preparation method thereof |
| CN114588306A (en) * | 2022-03-04 | 2022-06-07 | 广东舒尔康生物科技有限公司 | High-absorption polyurethane foam and preparation method thereof |
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Application publication date: 20170922 |