CN106581739A - Preparation method of composite absorbable protein-type non-sticky foam dressing - Google Patents
Preparation method of composite absorbable protein-type non-sticky foam dressing Download PDFInfo
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- CN106581739A CN106581739A CN201611030911.4A CN201611030911A CN106581739A CN 106581739 A CN106581739 A CN 106581739A CN 201611030911 A CN201611030911 A CN 201611030911A CN 106581739 A CN106581739 A CN 106581739A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0085—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention discloses a preparation method of a composite absorbable protein-type non-sticky foam dressing, and belongs to the technical field of preparation of medical dressings. The preparation method comprises the following steps: firstly, preparing human hair keratin powder from black human hair; then, crushing corn stalks and washing and drying the crushed corn stalks with a hydrogen peroxide solution, and heating and filtering collected dry fibers with keratinase, acrylic acid and the like; then, collecting a filter cake and drying and milling the filter cake, mixing the processed filter cake with polyether polyol 330N, the human hair keratin powder and the like, and curing an obtained mixture in a die, and finally, conducting demoulding so as to obtain the composite absorbable protein-type non-sticky foam dressing. The composite absorbable protein-type non-sticky foam dressing provided by the invention can form a wet environment in the surface area of a wound surface, so as to bring about benefits for promoting the growth of granulation tissues of the wound surface and to accelerate healing of the wound surfaces; meanwhile, the foam dressing provided by the invention is good in integrity after getting swollen and is the foam dressing is capable of effectively preventing fluid seepage; and the dressing is convenient to change and cannot remain in the wound surfaces or cause adhesion of wounds easily; therefore, the dressing has a broad application prospect.
Description
Technical field
The invention discloses a kind of absorbable compound protein type does not glue the preparation method of glutinous foam dressing, belong to medical dressing
Preparing technical field.
Background technology
Skin has internal protection, body temperature adjustment, the critical functions such as bacterium infection, consciousness, secretion is prevented, if occurring each
Wound or wound, burn, straw mat sore etc. are planted, that can lose its function.If losing its function, then be until wound heals completely
Only, pain is brought to patient, is such as damaged by serious, that can be subject to the danger of life, and after treatment end, because serious
Scar and give people to bring the pain of the 2nd time.
Foam type medical dressing is applied to wound granulation and forms the phase, unnecessary wound fluid can be absorbed, while can hinder
Every extraneous foreign matter and part bacterium, exposed nerve endings is protected, mitigate pain.Additionally, foam dressing is due to keeping moistening, from
And avoid the excessive vaporization of surface of a wound exudate and form dry scab, therefore property mechanicalness damage again will not be produced in more change dressings
Wound, is conducive to the healing of the surface of a wound.
The dressing of novel foam class is mainly made up of polyurethane and polyvinyl alcohol foam, and outer layer is hydrophobic material, and internal layer is parent
Water material, with porous, low surface tension, high resilience, plasticity it is strong, it is light the characteristics of, can to the absorbability of diffusate
10 times of dressing weight itself are reached, to oxygen and carbon dioxide almost full through can be used as pharmaceutical carrier, it is adaptable to middle amount
To the wound of a large amount of sepages, but a subject matter running into of this kind of foam dressing be when being exposed under corrosive fluid,
They are easily destroyed, and when these compositions are used as skin barrier, can absorb parameatal fluid, after absorbing fluid, dispersion
Hydrocolloid in rubber can be swelling, swelling to make dressing lose integrality.The skin barrier of integrality is lost, fluid can be caused
Seepage, dressing needs frequently to change, and residuals are frequently stayed on skin, while cell is possible to grow into hole, glues
Connect wound, so as to cause larger puzzlement to health care workers and patient.
The content of the invention
Present invention mainly solves technical problem：It is fragile when being exposed under corrosive fluid for existing foam dressing
It is bad, it is easily swelling to lose integrality, cause fluid seepage, and cell easily grows into dressing hole, causes the defect of wound adhesion, there is provided
It is a kind of easily to absorb amino acid and polypeptide structure by by human hair protein breakdown, forming human body, it is loaded in foam dressing by it,
During dressing use, while accelerating human body healing, human body is fully absorbed, do not produce the secondary phenomenon glued and stick, this
It is bright to prepare human hair keratin powder for raw material first with Black Human Hair, subsequently will wash with hydrogenperoxide steam generator after corn straw smashing
Wash, be dried, collect the heating such as gained dry fiber and keratinase, acrylic acid, filter, regather after filtration cakes torrefaction is milled with it is poly-
Ethoxylated polyhydric alcohol 330N, human hair keratin powder etc. mix and are put into mould maturation process, and the last demoulding can obtain a kind of absorbable
Compound protein type does not glue glutinous foam dressing, and the absorbable compound protein type of the present invention does not glue glutinous foam dressing can be in surface of a wound surface district
Domain forms moist environment, may advantageously facilitate the growth of wound granulation tissue, wound healing, while foam dressing of the present invention is molten
Swollen rear integrality is good, can effectively prevent fluid seepage, and change of dressing is convenient, is difficult to remain in the surface of a wound or adhesion wound, has
It is widely applied prospect.
In order to solve above-mentioned technical problem, the technical solution adopted in the present invention is：
（1）Black Human Hair is chosen, is cleaned and is dried naturally, crushed with airslide disintegrating mill and sieved, collect 75～80 mesh people
Hair powder end, in mass ratio 1:20, human hair powder is mixed with the stirring of the sodium hydroxide solution of mass fraction 10%, at 75～80 DEG C
2～3h of heating water bath, subsequently filters and collects filtrate, with 1mol/L salt acid for adjusting pH to 7.0, staticly settles 3～5h, subsequent mistake
Filter cake is filtered and collects, vacuum freeze drying is milled and is prepared into human hair keratin powder, standby；
（2）Maize straw is collected, is cleaned and be dried at being placed in 75～80 DEG C 6～8h, subsequently mill and cross 90～100 mesh
Sieve, collects to obtain maize straw powder, then in mass ratio 1:20, by maize straw powder and the hydrogenperoxide steam generator of mass fraction 10%
Stirring mixing, 2～3h of heating water bath at 45～50 DEG C subsequently stands and is cooled to room temperature, after spending ion-cleaning 3～5 times,
3～5h is dried at 65～70 DEG C；
（3）After the completion of to be dried, dry fiber is collected to obtain, counted by weight, respectively 10～15 parts of dry fibers of weighing, 15～
20 parts of keratinases, 65～70 parts of deionized waters, 15～20 parts of acrylic acid, 1～2 part of benzoyl peroxide and 1～2 part of persulfuric acid
Potassium is placed in there-necked flask, and in a nitrogen atmosphere, 6～8h of heating water bath at 65～70 DEG C subsequently filters and collect filter cake,
6～8h is dried at 65～75 DEG C, is milled and is prepared into modified resin microballoon；
（4）Count by weight, the modified resin of 25～30 parts of PPG 330N, 10～15 parts of above-mentioned preparations is weighed respectively
Microballoon, 15～20 parts of steps（1）Standby human hair keratin powder, 35～40 parts of deionized waters, 8～12 parts of dodecyl sulphates
Sodium, 1～2 part of stannous octoate and 15～20 parts of isocyanates are placed in beaker, at 25～30 DEG C, are stirred with 350～400r/min
20～25s of mixing is mixed, after the completion of mixing to be mixed, is collected at compound is placed in 45～50 DEG C in stainless steel mould, subsequently guarantor
Temperature 1～2h of curing, demoulding juxtaposition stands at room temperature 20～24h, you can be prepared into a kind of absorbable compound protein type viscous glutinous
Foam dressing.
The present invention application process be：First to scald and with the surface of a wound hydrogen peroxide flushing 3～5 times of inflammation, and will
The skin of wound circumference is dried, and the viscous glutinous foam dressing of compound protein type subsequently will be can absorb obtained in the present invention and is covered in wound
Face, and 2～4s is pressed lightly on, make dressing be brought into close contact the surface of a wound, fine or not situation is kept further according to wound fluid amount and dressing, often
1 dressing was changed every 1～3 day, until the surface of a wound heals completely.After testing, the obtained absorbable compound protein type of the present invention
It is 60～70MPa not glue glutinous foam dressing tensile strength, and 24h water absorptions are up to 2500～5500g/m2, swellability be 250～
360%th, up to 88～95%, water absorption rate is 860～980% to dressing integrality, moisturizing rate up to 98.2～99.5%, dressing water absorption is high,
Integrality is good, is difficult adhesion wound, while foam dressing of the present invention has preferable bacteriostasis, can completely kill dressing interface
Escherichia coli, staphylococcus aureus, Candida albicans, effectively prevent the foreign body rejection surface of a wound, its effective antibacterial cycle can tie up
Hold more than 7 days.
The invention has the beneficial effects as follows：
（1）Compound protein type of the invention obtained absorbable does not glue that glutinous foam dressing is easy to use, compliance is good, can effectively hinder
Every granulation tissue, it is to avoid be adhered between granulation tissue and dressing, cause to pull bleeding, the safety for the treatment of has been effectively ensured
Property, it is adaptable to the surface of a wound of corporal parts；
（2）Obtained absorbable compound protein type of the invention does not glue glutinous foam dressing and there is quick and powerful diffusate to absorb energy
Power, can be prevented effectively from wound dipping phenomenon, and foam dressing permeability of the present invention is low, makes the surface of a wound keep moistening, it is to avoid to change and apply
Mechanical injuries are again resulted in during material.
Specific embodiment
Black Human Hair is chosen first, is cleaned and is dried naturally, crushed with airslide disintegrating mill and sieved, collect 75～80
Mesh human hair powder, in mass ratio 1:20, human hair powder is mixed with the stirring of the sodium hydroxide solution of mass fraction 10%, 75～80
2～3h of heating water bath at DEG C, subsequently filters and collects filtrate, with 1mol/L salt acid for adjusting pH to 7.0, staticly settles 3～5h, with
After filter and collect filter cake, vacuum freeze drying is milled and is prepared into human hair keratin powder, standby；Maize straw is subsequently collected,
Cleaned and be dried at being placed in 75～80 DEG C 6～8h, subsequently milled and crossed 90～100 mesh sieves, collected to obtain maize straw powder,
Again in mass ratio 1:20, maize straw powder is mixed with the stirring of the hydrogenperoxide steam generator of mass fraction 10%, the water at 45～50 DEG C
Bath 2～3h of heating, subsequently stands and is cooled to room temperature, after spending ion-cleaning 3～5 times, 3～5h is dried at 65～70 DEG C；Treat
After the completion of drying, dry fiber is collected to obtain, counted by weight, 10～15 parts of dry fibers, 15～20 portions of angle eggs are weighed respectively
White enzyme, 65～70 parts of deionized waters, 15～20 parts of acrylic acid, 1～2 part of benzoyl peroxide and 1～2 part of potassium peroxydisulfate are placed in three
In mouth flask, in a nitrogen atmosphere, 6～8h of heating water bath at 65～70 DEG C subsequently filters and collects filter cake, at 65～75 DEG C
6～8h of lower drying, mills and is prepared into modified resin microballoon；Finally count by weight, 25～30 parts of polyether polyols are weighed respectively
Alcohol 330N, the modified resin microballoon of 10～15 parts of above-mentioned preparations, 15～20 parts of above-mentioned standby human hair keratin powder, 35～40
Part deionized water, 8～12 parts of lauryl sodium sulfate, 1～2 part of stannous octoate and 15～20 parts of isocyanates are placed in beaker,
At 25～30 DEG C, with 350～400r/min stirring 20～25s of mixing, after the completion of mixing to be mixed, collect compound and be placed in
At 45～50 DEG C in stainless steel mould, subsequently insulation cures 1～2h, and demoulding juxtaposition stands at room temperature 20～24h, you can prepare
Obtain a kind of absorbable compound protein type and do not glue glutinous foam dressing.
Example 1
Black Human Hair is chosen first, is cleaned and is dried naturally, crushed with airslide disintegrating mill and sieved, collect 75 mesh people's hair powder
End, in mass ratio 1:20, human hair powder is mixed with the stirring of the sodium hydroxide solution of mass fraction 10%, the heating water bath at 75 DEG C
2h, subsequently filters and collects filtrate, with 1mol/L salt acid for adjusting pH to 7.0, staticly settles 3h, subsequently filters and collect filter cake,
Vacuum freeze drying, mills and is prepared into human hair keratin powder, standby；Maize straw is subsequently collected, is cleaned and is placed in 75
6h is dried at DEG C, 90 mesh sieves are subsequently milled and cross, maize straw powder, then in mass ratio 1 is collected to obtain:20, by corn stalk powder
End mixes with the stirring of the hydrogenperoxide steam generator of mass fraction 10%, the heating water bath 2h at 45 DEG C, subsequently stands and is cooled to room temperature, uses
After deionization washs 3 times, at 65 DEG C 3h is dried；After the completion of to be dried, dry fiber is collected to obtain, counted by weight, respectively
Weigh 10 parts of dry fibers, 15 parts of keratinases, 65 parts of deionized waters, 15 parts of acrylic acid, 1 part of benzoyl peroxide and 1 part of mistake
Potassium sulfate is placed in there-necked flask, and in a nitrogen atmosphere, the heating water bath 6h at 65 DEG C subsequently filters and collect filter cake, 65
6h is dried at DEG C, is milled and is prepared into modified resin microballoon；Finally count by weight, 25 parts of PPGs are weighed respectively
330N, the modified resin microballoon of 10 parts of above-mentioned preparations, 15 parts of above-mentioned standby human hair keratin powder, 35 parts of deionized waters, 8 parts
Lauryl sodium sulfate, 1 part of stannous octoate and 15 parts of isocyanates are placed in beaker, mixed with 350r/min stirrings at 25 DEG C
20s is closed, after the completion of mixing to be mixed, is collected at compound is placed in 45 DEG C in stainless steel mould, subsequently insulation curing 1h, the demoulding
Juxtaposition stands at room temperature 20h, you can is prepared into a kind of absorbable compound protein type and does not glue glutinous foam dressing.
This example operation is easy, when using, first to scald and with the surface of a wound hydrogen peroxide flushing 3 times of inflammation, and will
The skin of wound circumference is dried, and the viscous glutinous foam dressing of compound protein type subsequently will be can absorb obtained in the present invention and is covered in wound
Face, and 2s is pressed lightly on, make dressing be brought into close contact the surface of a wound, fine or not situation is kept further according to wound fluid amount and dressing, every 1
It changes 1 dressing, until the surface of a wound heals completely.After testing, the obtained absorbable compound protein type of the present invention does not glue glutinous
Foam dressing tensile strength is 60MPa, and 24h water absorptions reach 2500g/m2, swellability be 250%, dressing integrality up to 88%, water suction
Rate is 860%, and, up to 98.2%, dressing water absorption is high, integrality is good, adhesion wound is difficult, while foam dressing of the present invention for moisturizing rate
With preferable bacteriostasis, Escherichia coli, staphylococcus aureus, the Candida albicans at dressing interface can be completely killed, be had
Effect prevents the foreign body rejection surface of a wound, and its effective antibacterial cycle can maintain 8 days.
Example 2
Black Human Hair is chosen first, is cleaned and is dried naturally, crushed with airslide disintegrating mill and sieved, collect 78 mesh people's hair powder
End, in mass ratio 1:20, human hair powder is mixed with the stirring of the sodium hydroxide solution of mass fraction 10%, the heating water bath at 78 DEG C
2h, subsequently filters and collects filtrate, with 1mol/L salt acid for adjusting pH to 7.0, staticly settles 4h, subsequently filters and collect filter cake,
Vacuum freeze drying, mills and is prepared into human hair keratin powder, standby；Maize straw is subsequently collected, is cleaned and is placed in 78
7h is dried at DEG C, 95 mesh sieves are subsequently milled and cross, maize straw powder, then in mass ratio 1 is collected to obtain:20, by corn stalk powder
End mixes with the stirring of the hydrogenperoxide steam generator of mass fraction 10%, the heating water bath 2h at 48 DEG C, subsequently stands and is cooled to room temperature, uses
After deionization washs 4 times, at 68 DEG C 4h is dried；After the completion of to be dried, dry fiber is collected to obtain, counted by weight, respectively
Weigh 13 parts of dry fibers, 18 parts of keratinases, 68 parts of deionized waters, 18 parts of acrylic acid, 1 part of benzoyl peroxide and 1 part of mistake
Potassium sulfate is placed in there-necked flask, and in a nitrogen atmosphere, the heating water bath 7h at 68 DEG C subsequently filters and collect filter cake, 70
7h is dried at DEG C, is milled and is prepared into modified resin microballoon；Finally count by weight, 28 parts of PPGs are weighed respectively
330N, the modified resin microballoon of 13 parts of above-mentioned preparations, 18 parts of above-mentioned standby human hair keratin powder, 38 parts of deionized waters, 10
Part lauryl sodium sulfate, 1 part of stannous octoate and 18 parts of isocyanates are placed in beaker, at 28 DEG C, with 375r/min stirrings
Mixing 23s, after the completion of mixing to be mixed, collects at compound is placed in 48 DEG C in stainless steel mould, and subsequently insulation curing 1h, takes off
Mould juxtaposition stands at room temperature 22h, you can is prepared into a kind of absorbable compound protein type and does not glue glutinous foam dressing.
This example operation is easy, when using, first to scald and with the surface of a wound hydrogen peroxide flushing 4 times of inflammation, and will
The skin of wound circumference is dried, and the viscous glutinous foam dressing of compound protein type subsequently will be can absorb obtained in the present invention and is covered in wound
Face, and 3s is pressed lightly on, make dressing be brought into close contact the surface of a wound, fine or not situation is kept further according to wound fluid amount and dressing, every 2
It changes 1 dressing, until the surface of a wound heals completely.After testing, the obtained absorbable compound protein type of the present invention does not glue glutinous
Foam dressing tensile strength is 65MPa, and 24h water absorptions reach 4000g/m2, swellability be 305%, dressing integrality up to 93%, water suction
Rate is 920%, and, up to 98.9%, dressing water absorption is high, integrality is good, adhesion wound is difficult, while foam dressing of the present invention for moisturizing rate
With preferable bacteriostasis, Escherichia coli, staphylococcus aureus, the Candida albicans at dressing interface can be completely killed, be had
Effect prevents the foreign body rejection surface of a wound, and its effective antibacterial cycle can maintain 9 days.
Example 3
Black Human Hair is chosen first, is cleaned and is dried naturally, crushed with airslide disintegrating mill and sieved, collect 80 mesh people's hair powder
End, in mass ratio 1:20, human hair powder is mixed with the stirring of the sodium hydroxide solution of mass fraction 10%, the heating water bath at 80 DEG C
3h, subsequently filters and collects filtrate, with 1mol/L salt acid for adjusting pH to 7.0, staticly settles 5h, subsequently filters and collect filter cake,
Vacuum freeze drying, mills and is prepared into human hair keratin powder, standby；Maize straw is subsequently collected, is cleaned and is placed in 80
8h is dried at DEG C, 100 mesh sieves are subsequently milled and cross, maize straw powder, then in mass ratio 1 is collected to obtain:20, by corn stalk powder
End mixes with the stirring of the hydrogenperoxide steam generator of mass fraction 10%, the heating water bath 3h at 50 DEG C, subsequently stands and is cooled to room temperature, uses
After deionization washs 5 times, at 70 DEG C 5h is dried；After the completion of to be dried, dry fiber is collected to obtain, counted by weight, respectively
Weigh 15 parts of dry fibers, 20 parts of keratinases, 70 parts of deionized waters, 20 parts of acrylic acid, 2 parts of benzoyl peroxides and 2 parts of mistakes
Potassium sulfate is placed in there-necked flask, and in a nitrogen atmosphere, the heating water bath 8h at 70 DEG C subsequently filters and collect filter cake, 75
8h is dried at DEG C, is milled and is prepared into modified resin microballoon；Finally count by weight, 30 parts of PPGs are weighed respectively
330N, the modified resin microballoon of 15 parts of above-mentioned preparations, 20 parts of above-mentioned standby human hair keratin powder, 40 parts of deionized waters, 12
Part lauryl sodium sulfate, 2 parts of stannous octoates and 20 parts of isocyanates are placed in beaker, at 30 DEG C, with 400r/min stirrings
Mixing 25s, after the completion of mixing to be mixed, collects at compound is placed in 50 DEG C in stainless steel mould, and subsequently insulation curing 2h, takes off
Mould juxtaposition stands at room temperature 24h, you can is prepared into a kind of absorbable compound protein type and does not glue glutinous foam dressing.
This example operation is easy, when using, first to scald and with the surface of a wound hydrogen peroxide flushing 5 times of inflammation, and will
The skin of wound circumference is dried, and the viscous glutinous foam dressing of compound protein type subsequently will be can absorb obtained in the present invention and is covered in wound
Face, and 4s is pressed lightly on, make dressing be brought into close contact the surface of a wound, fine or not situation is kept further according to wound fluid amount and dressing, every 3
It changes 1 dressing, until the surface of a wound heals completely.After testing, the obtained absorbable compound protein type of the present invention does not glue glutinous
Foam dressing tensile strength is 70MPa, and 24h water absorptions reach 5500g/m2, swellability be 360%, dressing integrality up to 95%, water suction
Rate is 980%, and, up to 99.5%, dressing water absorption is high, integrality is good, adhesion wound is difficult, while foam dressing of the present invention for moisturizing rate
With preferable bacteriostasis, Escherichia coli, staphylococcus aureus, the Candida albicans at dressing interface can be completely killed, be had
Effect prevents the foreign body rejection surface of a wound, and its effective antibacterial cycle can maintain 10 days.
Claims (1)
1. a kind of absorbable compound protein type does not glue the preparation method of glutinous foam dressing, it is characterised in that specifically preparation process is：
（1）Black Human Hair is chosen, is cleaned and is dried naturally, crushed with airslide disintegrating mill and sieved, collect 75～80 mesh people
Hair powder end, in mass ratio 1:20, human hair powder is mixed with the stirring of the sodium hydroxide solution of mass fraction 10%, at 75～80 DEG C
2～3h of heating water bath, subsequently filters and collects filtrate, with 1mol/L salt acid for adjusting pH to 7.0, staticly settles 3～5h, subsequent mistake
Filter cake is filtered and collects, vacuum freeze drying is milled and is prepared into human hair keratin powder, standby；
（2）Maize straw is collected, is cleaned and be dried at being placed in 75～80 DEG C 6～8h, subsequently mill and cross 90～100 mesh
Sieve, collects to obtain maize straw powder, then in mass ratio 1:20, by maize straw powder and the hydrogenperoxide steam generator of mass fraction 10%
Stirring mixing, 2～3h of heating water bath at 45～50 DEG C subsequently stands and is cooled to room temperature, after spending ion-cleaning 3～5 times,
3～5h is dried at 65～70 DEG C；
（3）After the completion of to be dried, dry fiber is collected to obtain, counted by weight, respectively 10～15 parts of dry fibers of weighing, 15～
20 parts of keratinases, 65～70 parts of deionized waters, 15～20 parts of acrylic acid, 1～2 part of benzoyl peroxide and 1～2 part of persulfuric acid
Potassium is placed in there-necked flask, and in a nitrogen atmosphere, 6～8h of heating water bath at 65～70 DEG C subsequently filters and collect filter cake,
6～8h is dried at 65～75 DEG C, is milled and is prepared into modified resin microballoon；
（4）Count by weight, the modified resin of 25～30 parts of PPG 330N, 10～15 parts of above-mentioned preparations is weighed respectively
Microballoon, 15～20 parts of steps（1）Standby human hair keratin powder, 35～40 parts of deionized waters, 8～12 parts of dodecyl sulphates
Sodium, 1～2 part of stannous octoate and 15～20 parts of isocyanates are placed in beaker, at 25～30 DEG C, are stirred with 350～400r/min
20～25s of mixing is mixed, after the completion of mixing to be mixed, is collected at compound is placed in 45～50 DEG C in stainless steel mould, subsequently guarantor
Temperature 1～2h of curing, demoulding juxtaposition stands at room temperature 20～24h, you can be prepared into a kind of absorbable compound protein type viscous glutinous
Foam dressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611030911.4A CN106581739A (en) | 2016-11-22 | 2016-11-22 | Preparation method of composite absorbable protein-type non-sticky foam dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611030911.4A CN106581739A (en) | 2016-11-22 | 2016-11-22 | Preparation method of composite absorbable protein-type non-sticky foam dressing |
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| Publication Number | Publication Date |
|---|---|
| CN106581739A true CN106581739A (en) | 2017-04-26 |
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| CN201611030911.4A Pending CN106581739A (en) | 2016-11-22 | 2016-11-22 | Preparation method of composite absorbable protein-type non-sticky foam dressing |
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