CN104667110A - Preparation method of medicine for treating children virus enteritis in pediatric examination room - Google Patents
Preparation method of medicine for treating children virus enteritis in pediatric examination room Download PDFInfo
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Abstract
The invention relates to a preparation method of a medicine for treating children virus enteritis in a pediatric examination room. The method can comprise the following steps: packing omei meadowrue herb, indian adenosma, barberry, herba pteridis multifidae, droughtdysentery holarrhena bark, caraway, longseed willowseed herb and trichothecium spp into a container; adding water, refluxing and heating for 4 hours, cooling a room temperature, and filtering; adding ethanol to filtrate until the content of ethanol is 80vol%; standing at a room temperature for 24 hours, filtering, recovering ethanol in the filtrate, and drying by distillation to obtain dried cream 1; packing bauhinia championii, elecampane, aster fastigiatus fisch, osbeckia chinensis, securidaca inappendieulata hassk, shortstyle cratoxylum leaf root bark, Japanese xylosma leaf, rungia pectinata, japanese smartweed, seeds of Chinese sumac, liquorice and wild spikenard stem and leaf into the container, adding ethanol water, heating for 5 hours under the reflux condition, cooling to the room temperature, filtering, recovering ethanol in the filtrate, drying by distillation to obtain a dried cream 2, and merging the dried cream 1 and the dried cream 2; and crushing, adding vaseline and wool fat, stirring evenly, and evenly smearing on non-woven fabrics.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to the preparation method of the medicine of a kind of children's's inspection chamber treatment infantile viral enteritis.
Background technology
Infantile viral enteritis is as one of clinical pediatric common disease, and account for department of pediatrics diarrhea disease sum about 50%-60%, autumn is multiple, causes because rotavirus or adenovirus etc. infect, and wherein rotavirus is topmost pathogenic former.Main clinical manifestation is upper respiratory tract infection, heating, vomiting, egg style or rare watery stool, and every day, times of defecation was inferior more than 10.As treated not in time, easily causing dehydration, acid base imbalance even suffers a shock, dead.Due to its PD be exceedingly fast, the course of disease is longer and symptom is heavier, thus timely and effectively treat infantile viral enteritis significant.
Doctor trained in Western medicine is thought, the pathogenesis of infantile viral enteritis is that virus invades small intestinal, 3-7 days incubation period and onset are anxious, the epithelial cell of the band brush border maturation on virus attack small intestinal mucosa fine hair top, this place's epithelial cell of After acute stage comes off mostly, and fine hair shortens, rust, the jejune cuboid cell without brush border instead of above-mentioned cell by rising bottom mucosa, cause Small Intestinal to decline, enteric cavity osmotic pressure changes, and the liquid entering enteric cavity increases and causes diarrhoea.Current primary disease is clinical adopts diet guide more; Drug therapy application antiviral, mucosa protective agent, microbial ecological agent, trace element supplement, fluid therapy, correction acidosis etc. are suited the medicine to the illness or Supporting Therapy; there is no specific treatment medicine; and inappropriate medication can cause Drug alteration of intestinal flora, the breeding of the anaerobic bacillus(cillus anaerobicus) of drug resistance can be invaded small intestinal and intestinal mucosa and secrete enterotoxin and be caused watery diarrhea to increase the weight of.
Infantile viral enteritis belongs to motherland's medical science and " to have loose bowels " category, thinks that " insufficiency of the spleen leading to overabundance of dampness " is for basic pathogenesis more, in treatment with " activating the spleen removing dampness " for the basic rule for the treatment of.The spleen and stomach in children functional development is not yet perfect, and no matter diseases caused by exogenous pathogenic factor or internal injury all can cause taste to receive the imbalance of fortune elevating function.Rotavirus enteritis at a time when the season of long summer, the heresy that susceptible is damp and hot, retention of heat due to blockage of dampness, foul middle resistance, spleen received failure of the spleen to transport and transform, lifting imbalance, clear QI being mixed up with turbid QI and causing is had loose bowels.The treatment clinical experience of Chinese medicine to primary disease enriches, and has efficient, safe unique advantage, has very high social and economic effects and wide DEVELOPMENT PROSPECT.
Summary of the invention
The object of this invention is to provide the preparation method, particularly a kind of preparation method for the treatment of the medicine of infantile viral enteritis of the medicine of a kind of children's's inspection chamber treatment infantile viral enteritis.
In order to realize object of the present invention, the invention provides the preparation method of the medicine of a kind of children's's inspection chamber treatment infantile viral enteritis, the method comprises the following steps:
(1) Caulis Bauhihiae Championii 100 grams, Thalictrum omeiense W. T. Wang et S. H. Wang 120 grams, Radix Inulae 50 grams, Herba Adenosmae 150 grams, Herba Turczaninowiae Fastigiatae 100 grams, Radix Berberidis Amurensis 80 grams, well limit grass 100 grams, Herba Osbeckiae 150 grams, 50 grams, five tastes rattan, Cortex Holarrhenae Antidysentericae 120 grams, Herba Ocimi (Herba Ocimi Pilosi) 100 grams, Herba Epilobii Pyrricholophi 100 grams, Folium cratoxyli ligustrini 80 grams, Ramulus et Folium xylosmae japonici 100 grams, Herba rungiae pectinatae 100 grams, shellflower 50 grams, Herba Polygoni japonici 100 grams, 50 grams, salt skin, 80 grams, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis 80 grams is taken;
(2) Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Adenosmae, Radix Berberidis Amurensis, Jing Biancao, Cortex Holarrhenae Antidysentericae, Herba Ocimi (Herba Ocimi Pilosi), Herba Epilobii Pyrricholophi, shellflower are loaded in container, add 5000 ml waters, reflux 4 hours, be cooled to room temperature, filter, in filtrate, add ethanol to alcohol content is 80 volume %, and room temperature is placed after 24 hours and filtered, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 1;
(3) Caulis Bauhihiae Championii, Radix Inulae, Herba Turczaninowiae Fastigiatae, Herba Osbeckiae, five tastes rattan, Folium cratoxyli ligustrini, Ramulus et Folium xylosmae japonici, Herba rungiae pectinatae, Herba Polygoni japonici, salt skin, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis are loaded in container, add the ethanol water of 6000 milliliter of 85 volume %, heating 5 hours under the condition of backflow, then room temperature is cooled to, filter, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 2; And
(4) merge described dry cream 1, dry cream 2, pulverize, add 400 grams, vaseline and lanoline 200 grams, stir, uniform application is on 400 blocks of non-woven fabrics, and every block non-woven fabrics is long and wide is 10 centimetres, and thickness is 1 centimetre.
The present invention also provides a kind of preparation method for the treatment of the medicine of infantile viral enteritis, and the method comprises the following steps:
(1) Caulis Bauhihiae Championii 100 grams, Thalictrum omeiense W. T. Wang et S. H. Wang 120 grams, Radix Inulae 50 grams, Herba Adenosmae 150 grams, Herba Turczaninowiae Fastigiatae 100 grams, Radix Berberidis Amurensis 80 grams, well limit grass 100 grams, Herba Osbeckiae 150 grams, 50 grams, five tastes rattan, Cortex Holarrhenae Antidysentericae 120 grams, Herba Ocimi (Herba Ocimi Pilosi) 100 grams, Herba Epilobii Pyrricholophi 100 grams, Folium cratoxyli ligustrini 80 grams, Ramulus et Folium xylosmae japonici 100 grams, Herba rungiae pectinatae 100 grams, shellflower 50 grams, Herba Polygoni japonici 100 grams, 50 grams, salt skin, 80 grams, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis 80 grams is taken;
(2) Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Adenosmae, Radix Berberidis Amurensis, Jing Biancao, Cortex Holarrhenae Antidysentericae, Herba Ocimi (Herba Ocimi Pilosi), Herba Epilobii Pyrricholophi, shellflower are loaded in container, add 5000 ml waters, reflux 4 hours, be cooled to room temperature, filter, in filtrate, add ethanol to alcohol content is 80 volume %, and room temperature is placed after 24 hours and filtered, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 1;
(3) Caulis Bauhihiae Championii, Radix Inulae, Herba Turczaninowiae Fastigiatae, Herba Osbeckiae, five tastes rattan, Folium cratoxyli ligustrini, Ramulus et Folium xylosmae japonici, Herba rungiae pectinatae, Herba Polygoni japonici, salt skin, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis are loaded in container, add the ethanol water of 6000 milliliter of 85 volume %, heating 5 hours under the condition of backflow, then room temperature is cooled to, filter, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 2; And
(4) merge described dry cream 1, dry cream 2, pulverize, add 400 grams, vaseline and lanoline 200 grams, stir, uniform application is on 400 blocks of non-woven fabrics, and every block non-woven fabrics is long and wide is 10 centimetres, and thickness is 1 centimetre.
The present invention also provides the purposes of compositions in the medicine of preparation treatment infantile viral enteritis, it is characterized in that described compositions is made up of the material of following weight portion: Caulis Bauhihiae Championii 5-15 part, Thalictrum omeiense W. T. Wang et S. H. Wang 5-15 part, Radix Inulae 1-10 part, Herba Adenosmae 10-20 part, Herba Turczaninowiae Fastigiatae 5-15 part, Radix Berberidis Amurensis 1-10 part, well limit grass 5-15 part, Herba Osbeckiae 10-20 part, five tastes rattan 1-10 part, Cortex Holarrhenae Antidysentericae 5-15 part, Herba Ocimi (Herba Ocimi Pilosi) 5-15 part, Herba Epilobii Pyrricholophi 5-15 part, Folium cratoxyli ligustrini 1-10 part, Ramulus et Folium xylosmae japonici 5-15 part, Herba rungiae pectinatae 5-15 part, shellflower 1-10 part, Herba Polygoni japonici 5-15 part, salt skin 1-10 part, Radix Glycyrrhizae 1-10 part, Caulis et Folium Hyptidis suaveolentis 1-10 part.
Preferably, described compositions is made up of the material of following weight portion: Caulis Bauhihiae Championii 10 parts, Thalictrum omeiense W. T. Wang et S. H. Wang 12 parts, Radix Inulae 5 parts, Herba Adenosmae 15 parts, Herba Turczaninowiae Fastigiatae 10 parts, Radix Berberidis Amurensis 8 parts, well limit grass 10 parts, Herba Osbeckiae 15 parts, 5 parts, five tastes rattan, Cortex Holarrhenae Antidysentericae 12 parts, Herba Ocimi (Herba Ocimi Pilosi) 10 parts, Herba Epilobii Pyrricholophi 10 parts, Folium cratoxyli ligustrini 8 parts, Ramulus et Folium xylosmae japonici 10 parts, Herba rungiae pectinatae 10 parts, shellflower 5 parts, Herba Polygoni japonici 10 parts, 5 parts, salt skin, 8 parts, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis 8 parts.
More preferably, described pharmaceutical composition can be tablet, dispersible tablet, capsule, soft capsule or patch.
Compositions of the present invention is with the prescription compatibility theory of " monarch, minister, help, make " for instructing appropriate compatibility, and wherein Herba Adenosmae, Herba Turczaninowiae Fastigiatae, Cortex Holarrhenae Antidysentericae are monarch drug; Thalictrum omeiense W. T. Wang et S. H. Wang, Radix Berberidis Amurensis, Herba Epilobii Pyrricholophi, Folium cratoxyli ligustrini, Herba Polygoni japonici are ministerial drug; Caulis Bauhihiae Championii, Radix Inulae, Jing Biancao, Herba Osbeckiae, five tastes rattan, Herba Ocimi (Herba Ocimi Pilosi), Ramulus et Folium xylosmae japonici, Herba rungiae pectinatae, shellflower, salt skin, Caulis et Folium Hyptidis suaveolentis are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Pharmaceutical composition of the present invention is from integral status, giving consideration to both the incidental and fundamental, full side plays the merit of heat clearing away of inducing sweat, eliminating dampness to stop diarrhea, invigorating the spleen and regulating the stomach altogether, and can strengthen anti-virus ability, improves intestinal digestive and absorptive functions, treatment infantile viral enteritis is evident in efficacy, and shorten the course for the treatment of, and have no side effect over the course for the treatment of, application safety, drug resistance can not occur, clinic is promoted.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment pharmaceutical composition of the present invention
For patch, the preparation method of pharmaceutical composition of the present invention is as follows:
(1) Caulis Bauhihiae Championii 100 grams, Thalictrum omeiense W. T. Wang et S. H. Wang 120 grams, Radix Inulae 50 grams, Herba Adenosmae 150 grams, Herba Turczaninowiae Fastigiatae 100 grams, Radix Berberidis Amurensis 80 grams, well limit grass 100 grams, Herba Osbeckiae 150 grams, 50 grams, five tastes rattan, Cortex Holarrhenae Antidysentericae 120 grams, Herba Ocimi (Herba Ocimi Pilosi) 100 grams, Herba Epilobii Pyrricholophi 100 grams, Folium cratoxyli ligustrini 80 grams, Ramulus et Folium xylosmae japonici 100 grams, Herba rungiae pectinatae 100 grams, shellflower 50 grams, Herba Polygoni japonici 100 grams, 50 grams, salt skin, 80 grams, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis 80 grams is taken;
(2) Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Adenosmae, Radix Berberidis Amurensis, Jing Biancao, Cortex Holarrhenae Antidysentericae, Herba Ocimi (Herba Ocimi Pilosi), Herba Epilobii Pyrricholophi, shellflower are loaded in container, add 5000 ml waters, reflux 4 hours, be cooled to room temperature, filter, in filtrate, add ethanol to alcohol content is 80 volume %, and room temperature is placed after 24 hours and filtered, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 1;
(3) Caulis Bauhihiae Championii, Radix Inulae, Herba Turczaninowiae Fastigiatae, Herba Osbeckiae, five tastes rattan, Folium cratoxyli ligustrini, Ramulus et Folium xylosmae japonici, Herba rungiae pectinatae, Herba Polygoni japonici, salt skin, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis are loaded in container, add the ethanol water of 6000 milliliter of 85 volume %, heating 5 hours under the condition of backflow, then room temperature is cooled to, filter, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 2; And
(4) merge described dry cream 1, dry cream 2, pulverize, add 400 grams, vaseline and lanoline 200 grams, stir, uniform application is on 400 blocks of non-woven fabrics.Every block non-woven fabrics is long and wide is 10 centimetres, and thickness is 1 centimetre.
The curative effect of experimental example pharmaceutical composition of the present invention
1 data and method
1.1 physical data
This papova enteritis infant is totally 60 examples, all meet with reference to Ministry of Health of the People's Republic of China " Chinese diarrhoeal diseases diagnoses and treatment scheme " (1998) and " all good fortune Chinese bush cherry practical paidonosologies " (Hu Yamei, virtue will be carried, People's Health Publisher, 2002,7th edition, 851st page) diagnostic criteria of formulating: times of defecation increases, every day 3 ~ 5 times, notably nearly more than 10 times, in faint yellow, as egg soup sample.Or with Nausea and vomiting, stomachache, heating, the disease such as thirsty, heavy then have dehydration performance; There is excess in feeding, unhygienic diet or experience the medical history of seasonal pathogen; Stool routine examination inspection visible significant quantities of fat ball or leukocyte, erythrocyte are a little; Stool wheel virus antigen tests positive.60 routine infants are divided into observation group 30 example and matched group 30 example.Wherein observation group man 20 example, female 10 example; Age between 6 months-5 years old, 1.3 years old mean age; Average 6.1 ± 1.4 days of the course of disease.Matched group man 18 example, female 12 example; Age between 6 months-4 years old, 1.5 years old mean age; Average 5.9 ± 1.5 days of the course of disease.Two groups of infants, at the equal not statistically significant of the difference of above-mentioned each side (p > 0.05), have comparability.
1.2 Therapeutic Method
Observation group uses the patch of the present invention prepared in embodiment to treat, and 1 piece of patch is attached to umbilical part, 1 subsides/sky.Matched group takes montmorillonite powder (dioctahedral smectite, authentication code: the accurate word H20000690 of traditional Chinese medicines, Beaufour-lpsen Tianjin pharmaceutical Co. Ltd produces), 1 bag of (3 grams)/day of less than 2 years old infant, more than 2 years old infant 2 bags (6 grams)/days, divide equally 3 times and take.Two groups was all a course for the treatment of with 7 days, treated 1 course for the treatment of.
1.3 criterion of therapeutical effect
Formulate as follows with reference to criterion of therapeutical effect relevant in " practical combination of Chinese and Western medicine diagnoses and treatment " (Chen Guiyan, Yang Sishu, China Medical Science Press, 1991):
Recovery from illness: in 1 ~ 4 day, diarrhoea only, is defecated 1 time every day, stool is shaped or is substantially shaped, and microscopy is normal, other transference cures.
Effective: to suffer from diarrhoea in 5 ~ 6 days and significantly alleviate, defecate every day 2 ~ 3 times, other symptoms are obviously improved, and microscopy is normal;
Invalid: after treatment, diarrhoea number of times is without obvious change, symptom and sign are all without improvement.
1.4 statistical method
SPSS13.0 statistical software is adopted to carry out data analysis.Enumeration data adopts x
2inspection, with p < 0.05 for difference has statistical significance.
2 results
The antidiarrheal time of observation group and matched group infant is respectively 3.1 ± 0.7 days and 5.9 ± 1.2 days, and the antidiarrheal time of observation group is significantly shorter than matched group, and between group, comparing difference has statistical significance (p<0.05).
Two groups of infant clinical efficacies relatively in table 1.
The comparison of table 1 clinical efficacy
Note: compare with matched group, * p<0.05
As can be seen from Table 1, the difference of two groups of infant clinical efficacies has statistical significance (p<0.05).This shows that observation group's symptom takes a turn for the better and is better than matched group, and the clinical efficacy of pharmaceutical composition of the present invention is definite, treatment infantile viral enteritis Be very effective.
Claims (4)
1. a preparation method for the medicine of children's's inspection chamber treatment infantile viral enteritis, the method can comprise the following steps:
(1) Caulis Bauhihiae Championii 100 grams, Thalictrum omeiense W. T. Wang et S. H. Wang 120 grams, Radix Inulae 50 grams, Herba Adenosmae 150 grams, Herba Turczaninowiae Fastigiatae 100 grams, Radix Berberidis Amurensis 80 grams, well limit grass 100 grams, Herba Osbeckiae 150 grams, 50 grams, five tastes rattan, Cortex Holarrhenae Antidysentericae 120 grams, Herba Ocimi (Herba Ocimi Pilosi) 100 grams, Herba Epilobii Pyrricholophi 100 grams, Folium cratoxyli ligustrini 80 grams, Ramulus et Folium xylosmae japonici 100 grams, Herba rungiae pectinatae 100 grams, shellflower 50 grams, Herba Polygoni japonici 100 grams, 50 grams, salt skin, 80 grams, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis 80 grams is taken;
(2) Thalictrum omeiense W. T. Wang et S. H. Wang, Herba Adenosmae, Radix Berberidis Amurensis, Jing Biancao, Cortex Holarrhenae Antidysentericae, Herba Ocimi (Herba Ocimi Pilosi), Herba Epilobii Pyrricholophi, shellflower are loaded in container, add 5000 ml waters, reflux 4 hours, be cooled to room temperature, filter, in filtrate, add ethanol to alcohol content is 80 volume %, and room temperature is placed after 24 hours and filtered, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 1;
(3) Caulis Bauhihiae Championii, Radix Inulae, Herba Turczaninowiae Fastigiatae, Herba Osbeckiae, five tastes rattan, Folium cratoxyli ligustrini, Ramulus et Folium xylosmae japonici, Herba rungiae pectinatae, Herba Polygoni japonici, salt skin, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis are loaded in container, add the ethanol water of 6000 milliliter of 85 volume %, heating 5 hours under the condition of backflow, then room temperature is cooled to, filter, reclaim the ethanol in filtrate, evaporate to dryness obtains dry cream 2; And
(4) merge described dry cream 1, dry cream 2, pulverize, add 400 grams, vaseline and lanoline 200 grams, stir, uniform application is on 400 blocks of non-woven fabrics, and every block non-woven fabrics is long and wide is 10 centimetres, and thickness is 1 centimetre.
2. the purposes of compositions in the medicine of preparation treatment infantile viral enteritis, it is characterized in that described compositions is made up of the material of following weight portion: Caulis Bauhihiae Championii 5-15 part, Thalictrum omeiense W. T. Wang et S. H. Wang 5-15 part, Radix Inulae 1-10 part, Herba Adenosmae 10-20 part, Herba Turczaninowiae Fastigiatae 5-15 part, Radix Berberidis Amurensis 1-10 part, well limit grass 5-15 part, Herba Osbeckiae 10-20 part, five tastes rattan 1-10 part, Cortex Holarrhenae Antidysentericae 5-15 part, Herba Ocimi (Herba Ocimi Pilosi) 5-15 part, Herba Epilobii Pyrricholophi 5-15 part, Folium cratoxyli ligustrini 1-10 part, Ramulus et Folium xylosmae japonici 5-15 part, Herba rungiae pectinatae 5-15 part, shellflower 1-10 part, Herba Polygoni japonici 5-15 part, salt skin 1-10 part, Radix Glycyrrhizae 1-10 part, Caulis et Folium Hyptidis suaveolentis 1-10 part.
3. purposes according to claim 2, wherein said compositions is made up of the material of following weight portion: Caulis Bauhihiae Championii 10 parts, Thalictrum omeiense W. T. Wang et S. H. Wang 12 parts, Radix Inulae 5 parts, Herba Adenosmae 15 parts, Herba Turczaninowiae Fastigiatae 10 parts, Radix Berberidis Amurensis 8 parts, well limit grass 10 parts, Herba Osbeckiae 15 parts, 5 parts, five tastes rattan, Cortex Holarrhenae Antidysentericae 12 parts, Herba Ocimi (Herba Ocimi Pilosi) 10 parts, Herba Epilobii Pyrricholophi 10 parts, Folium cratoxyli ligustrini 8 parts, Ramulus et Folium xylosmae japonici 10 parts, Herba rungiae pectinatae 10 parts, shellflower 5 parts, Herba Polygoni japonici 10 parts, 5 parts, salt skin, 8 parts, Radix Glycyrrhizae, Caulis et Folium Hyptidis suaveolentis 8 parts.
4. purposes according to claim 3, wherein said medicine can be tablet, dispersible tablet, capsule, soft capsule or patch.
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| 周小翠等: "中药经皮给药佐治小儿腹泻疗效观察", 《中外妇儿健康》 * |
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| CN104689204A (en) * | 2015-03-31 | 2015-06-10 | 戴惠英 | Pharmaceutical composition for treating infantile virus enteritis |
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Application publication date: 20150603 |