CN104666971A - Traditional Chinese medicine capable of reducing blood sugar - Google Patents

Abstract

The invention relates to a traditional Chinese medicine capable of reducing blood sugar. The traditional Chinese medicine comprises 10-15 parts of radix astragali, 10-20 parts of ginseng, 8-15 parts of Mongolian snakegourd root, 10-15 parts of kudzuvine root, 8-15 parts of corn stigma, 8-15 parts of fragrant solomonseal rhizome, 6-10 parts of barbary wolfberry fruit, 10-15 parts of common anemarrhena rhizome, 6-10 parts of rehmannia root, 6-10 parts of Chinese wolfberry root-bark and 6-10 parts of balsam pear. The traditional Chinese medicine is jointly prepared from the following traditional Chinese medicine active pharmaceutical ingredients in parts by weight: 12 parts of radix astragali, 15 parts of ginseng, 10 parts of Mongolian snakegourd root, 12 parts of kudzuvine root, 10 parts of corn stigma, 10 parts of fragrant solomonseal rhizome, 8 parts of barbary wolfberry fruit, 12 parts of common anemarrhena rhizome, 8 parts of rehmannia root, 8 parts of Chinese wolfberry root-bark and 8 parts of balsam pear. The traditional Chinese medicine is suitable for patients with diabetes mellitus at the initial stage, is capable of effectively reducing blood sugar and preventing conditions from worsening and has low toxic and side effects.

Description

A kind of hypoglycemic Chinese medicine

Technical field

The present invention relates to a kind of hypoglycemic Chinese medicine.

Background technology

Diabetes (Diabetes Mellitus) be a complex disease because of syndrome, be because the hormone of insulin deficit in body or antagonism insulin increases, or insulin can not be brought into normal play physiological action and a kind of syndrome of glucose, protein and lipid metabolic disorder of causing in target cell.To it is characterized by blood circulation that concentration of glucose is abnormal to be raised and glucose in urine, blood glucose can occur typical three-many-one-little symptom time too high, i.e. polydipsia, polyuria, polyphagia and lose weight, and with fatigue and weak.Can be there is ketoacidosis, hypertonicity diabetic coma in severe patient, and easily merge multi-infection.Along with the prolongation of the course of disease, its metabolism disorder can cause the chronic progressive external pathological changes of the histoorgans such as eye, kidney, nerve, blood vessel and heart.If can not get treatment appropriate in time, then can there is heart change, cerebrovascular disease, renal failure, lose the sight of both eyes, lower limb gangrene etc. and become the lethal main cause disabled.Because the cause of disease of primary diabetes mellitus is illustrated so far not yet completely, therefore diabetes there is no radical cure measure so far.

Adopt the treatment of Diet Therapy, exercise therapy, oral antidiabetic drug, insulin and traditional medicine, can only symptom management, but can't diabetes be effected a radical cure at present.

Summary of the invention

The invention provides a kind of hypoglycemic Chinese medicine, be applicable to diabetes mellitus patient, effectively can reduce blood glucose, prevent that sb.'s illness took a turn for the worse, toxic and side effects is low.

For this reason, the invention provides following Chinese medicine: comprise Radix Astragali 10-15 part, Radix Ginseng 10-20 part, Radix Trichosanthis 8-15 part, Radix Puerariae 10-15 part, Stigma Maydis 8-15 part, Rhizoma Polygonati Odorati 8-15 part, Fructus Lycii 6-10 part, Rhizoma Anemarrhenae 10-15 part, Radix Rehmanniae 6-10 part, Cortex Lycii 6-10 part, Fructus Momordicae charantiae 6-10 part.

Above-mentioned Chinese medicine is formed by following weight parts raw material of Chinese medicine medicine system of closing: the Radix Astragali 12 parts, Radix Ginseng 15 parts, Radix Trichosanthis 10 parts, Radix Puerariae 12 parts, Stigma Maydis 10 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Lycii 8 parts, the Rhizoma Anemarrhenae 12 parts, Radix Rehmanniae 8 parts, Cortex Lycii 8 parts, 8 parts, Fructus Momordicae charantiae.

Medical material selected by the present invention and pharmacology as follows:

The Radix Astragali: sweet, tepor.Return lung, spleen, liver, kidney channel.Consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage, the treatment deficiency of vital energy.The Radix Astragali, by increasing glycogen synthase activity, IRS activity, protein kinase B and protein kinase C activity, makes glycogen synthase activity increase and play increase insulin sensitivity, hypoglycemic effect.

Radix Ginseng: Radix Ginseng can promote that laboratory animal blood glucose reduces, and the rising of diabetic blood fat and unable symptom can be reduced.Clinical report Radix Ginseng extractum has therapeutic effect to early stage mild diabetes, and glucose in urine is reduced, and blood glucose reduces, curative effect still sustainable more than 2 weeks after drug withdrawal.

Radix Trichosanthis: sweet, micro-hardship, is slightly cold.Attach to the lung and stomach meridians.Clearing away heat and promoting production of body fluid, detumescence and apocenosis.Treated With Trichosanthin diabetes Be very effective.

Radix Puerariae: this product can relieving muscles diaphoresis, invigorating YANG QI to promote eruption, antipyreticly to promote the production of body fluid, there is the hypoglycemic activity shown.

Stigma Maydis: leaven has obvious hypoglycemic activity to laboratory animal diabetes, and effect is improved to diabetic hypertension, nephropathy.

Rhizoma Polygonati Odorati: with 0.5g/kg Rhizoma Polygonati Odorati preserved material to rabbit intramuscular injection, can make blood glucose raise.Oral Rhizoma Polygonati Odorati extractum, then blood glucose is fallen after rising, and has significant inhibitory action to the hyperglycemia that epinephrine causes, right glucose, alloxanthe Hyperglycemia In Stz-induced Diabetic Rats caused also has inhibitory action.

Fructus Lycii: wolfberry fruit extract significantly and lastingly can reduce rat blood sugar, increase carbohydrate tolerance, and toxicity is less.In addition, these product also have antitumor, promote the effects such as hemopoietic function.

The Rhizoma Anemarrhenae: bitter, sweet, cold.Return lung, stomach, kidney channel.Clearing away heat-fire, promotes the production of body fluid and moisturizes.Rhizoma Anemarrhenae water logging extract, can reduce the blood sugar level of normal rabbit, particularly to the close pyridine of four oxygen diabetesrabbit effect is more remarkable.

Radix Rehmanniae: sweetness and bitterness is cool.Enter the heart, liver, kidney channel.Can reduce euglycemia and by epinephrine, the hyperglycemia that causes of ammonia chloride.Once report was had, rabbit hemostasis Radix Rehmanniae alcohol extractum solution2g/kg or gavage 4g/kg all can make blood glucose decline.

Cortex Lycii: sweet, cold.Return lung, kidney channel.Removing heat from blood moves back steaming, eliminating heat from the lung.Preserved material, decoct, tincture and injection all have obvious hypotensive effect.Slight hypoglycemic activity is had to rabbit.And have the effect reducing serum total cholesterol content.

Fructus Momordicae charantiae: bitter in the mouth cold in nature, enter the heart, lung, stomach, has that clearing away summer-heat quenches one's thirst, blood pressure lowering, blood fat, skin maintenance, the function such as enhances metabolism.Reduce blood glucose effect.After rabbit that is normal and trouble alloxan diabetes gavages Fructus Momordicae charantiae juice, blood glucose can be made obviously to reduce.

The present invention reacts this product and has the function reducing hyperglycemia after hyperglycemic patients is taken, and has the features such as bioavailability is high, taking convenience simultaneously.

Detailed description of the invention

Embodiment 1:

Filter out the Radix Astragali 12 parts, Radix Ginseng 15 parts, Radix Trichosanthis 10 parts, Radix Puerariae 12 parts, Stigma Maydis 10 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Lycii 8 parts, the Rhizoma Anemarrhenae 12 parts, Radix Rehmanniae 8 parts, Cortex Lycii 8 parts, 8 parts, Fructus Momordicae charantiae, 30 parts are divided into be the consumption of month, every day gets portion and decocts, cold water soak 20 minutes are first used before decoction, pulled out into marmite, after the cold water of medical material 3 times of reinjecting boils with high heat, use slow fire instead and simmer 30 minutes, midway need stir twice.After cooked, take concoction, every agent medicine can decoction twice.Second time injects the water continuation decoction of 2 times, and decocting time can shorten 10 points of kinds.Sooner or later service once, contraindication in pregnancy.

Embodiment 2:

Filter out the Radix Astragali 12 parts, Radix Ginseng 15 parts, Radix Trichosanthis 10 parts, Radix Puerariae 12 parts, Stigma Maydis 10 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Lycii 8 parts, the Rhizoma Anemarrhenae 12 parts, Radix Rehmanniae 8 parts, Cortex Lycii 8 parts, 8 parts, Fructus Momordicae charantiae, after water extraction, under 60 DEG C of conditions, microwave drying must extract dry thing, drying and crushing crosses 120 mesh sieves, add Mel and make big honeyed pills agent, be divided into 30 parts, every day is a.

Embodiment 3:

Filter out the Radix Astragali 12 parts, Radix Ginseng 15 parts, Radix Trichosanthis 10 parts, Radix Puerariae 12 parts, Stigma Maydis 10 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Lycii 8 parts, the Rhizoma Anemarrhenae 12 parts, Radix Rehmanniae 8 parts, Cortex Lycii 8 parts, 8 parts, Fructus Momordicae charantiae, crushed after being dried becomes fine powder, cross 120 mesh sieves, with water pill, dry sepia watered pill, is divided into 30 parts.Oral, three times on the one, warm water takes.

clinical experiment is observed:

(1) Therapeutic Method:

Select age 48-58 year patient 100 example, 55 years old mean age ,-8 years April of the course of disease, average course of disease 6 months.Patient did not accept other treatment before this treatment, surveyed its blood glucose and all exceeded normal value, and equal nongenetic diabetes.Within 30 days, be a course for the treatment of, after 30 days, carry out symptom score.

Treatment group 1(20 people): the medicine giving the embodiment of the present invention one, take one month.

Treatment group 2(20 people): the medicine giving the embodiment of the present invention two, take one month.

Treatment group 3(20 people): the medicine giving the embodiment of the present invention three, take one month.

Control group A (20 people): take conventional western medicine glipizidecarry out blood sugar lowering.

Matched group B(20 people): do not take any medicine.

(2) efficacy assessment standard:

Effective: clinical symptoms disappears substantially, on an empty stomach venous bloodslurry blood glucose 3.9 ~ 6.0mmol/L, after the meal venous bloodslurry blood glucose < 7.8mmol/L.

Invalid: to compare with before treatment, the unchanged or exacerbation of symptoms of every Physico-chemical tests index.

Bounce-back: measure high pressure blood pressure after referring to drug withdrawal and be all greater than normal value.

(3) therapeutic outcome sees the following form:

Detect the safety indexes for the treatment of group patient, do not find liver, kidney, core function abnormality, hematuria just checks and meets conventional criteria.Treatment group 1, treatment group 2 and treatment group 3 strictly press prescriptions, medication 1 month, successful, and it is high that control group A takes common Western medicine blood sugar lowering rebound rate, and dependency is strong, and have the people of 5% to occur feeling sick, the side effect such as gastrointestinal upset.

Claims (2)

1. a hypoglycemic Chinese medicine, is characterized in that: the present invention comprises Radix Astragali 10-15 part, Radix Ginseng 10-20 part, Radix Trichosanthis 8-15 part, Radix Puerariae 10-15 part, Stigma Maydis 8-15 part, Rhizoma Polygonati Odorati 8-15 part, Fructus Lycii 6-10 part, Rhizoma Anemarrhenae 10-15 part, Radix Rehmanniae 6-10 part, Cortex Lycii 6-10 part, Fructus Momordicae charantiae 6-10 part.

2. hypoglycemic Chinese medicine according to claim 1, is characterized in that: it is formed by following weight parts raw material of Chinese medicine medicine system of closing: the Radix Astragali 12 parts, Radix Ginseng 15 parts, Radix Trichosanthis 10 parts, Radix Puerariae 12 parts, Stigma Maydis 10 parts, Rhizoma Polygonati Odorati 10 parts, Fructus Lycii 8 parts, the Rhizoma Anemarrhenae 12 parts, Radix Rehmanniae 8 parts, Cortex Lycii 8 parts, 8 parts, Fructus Momordicae charantiae.