CN104666596B - A kind of Chinese medicine preparation and preparation method thereof for treating pernio - Google Patents
A kind of Chinese medicine preparation and preparation method thereof for treating pernio Download PDFInfo
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- CN104666596B CN104666596B CN201510067953.4A CN201510067953A CN104666596B CN 104666596 B CN104666596 B CN 104666596B CN 201510067953 A CN201510067953 A CN 201510067953A CN 104666596 B CN104666596 B CN 104666596B
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Abstract
The present invention relates to a kind of Chinese medicine preparations and preparation method thereof for treating pernio, belong to field of medicaments.The object of the present invention is to provide it is a kind of it is easy to use, curative effect is apparent, cure rate is high, difficulty in relapse after healing, there is promoting blood circulation to remove blood stasis, the Chinese medicine preparation of the treatment pernio of antalgic and other effects.A kind of Chinese medicine preparation for treating pernio, counts mainly be made of following raw materials in parts by weight：10 30 parts of Radix Angelicae Sinensis, 5 25 parts of Chinese cassia tree, 5 35 parts of Radix Salviae Miltiorrhizae, 5 20 parts of safflower, 5 30 parts of Asian puccoon, 10 35 parts of capsicum.Compared with prior art, the present invention having the following advantages that：1, promoting blood circulation to remove blood stasis, antalgic, mild in medicine property and.2, easy to use, curative effect is apparent, cure rate is high, difficulty in relapse after healing.3, the scar that pernio leaves is dispelled.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparations and preparation method thereof for treating pernio, belong to field of medicaments.
Background technology
Pernio is the damage caused by Persistent Low Temperature, moist invasion, and human body heat production is few, and heat dissipation is more, and body heat is not
Foot makes continuous vessel shrink, causes tissue edema, dysbolism.It is apt to occur in brothers' back of the body, heel refers to toe, auricle and nose etc.
Place, damage is not of uniform size, and from the beginning of for red or aubergine congestive erythema, the colour fading of pressure goes red slowly recovery after pressure, seriously
Person can have bubble, and ulcer is formed after broken, feel local swelling, ice-cold, have itch, scorching hot or feeling of pain rear often to lose after warm heat
Leave atrophic scar.
Currently, in the market it is existing treatment pernio drug exist mostly effect is poor, treatment cycle length, cannot thoroughly cure
The shortcomings of.
Invention content
Present invention aim to address problems of the prior art, provide it is a kind of it is easy to use, curative effect is apparent, cures
Rate height, difficulty in relapse after healing, have promoting blood circulation to remove blood stasis, the Chinese medicine preparation of the treatment pernio of antalgic and other effects.
To achieve the above object, the present invention adopts the following technical scheme that：A kind of Chinese medicine preparation for treating pernio, by weight
Number meter is mainly made of following raw materials：10-30 parts of Radix Angelicae Sinensis, 5-25 parts of Chinese cassia tree, 5-35 parts of Radix Salviae Miltiorrhizae, 5-20 parts of safflower, Asian puccoon 5-30
Part, 10-35 parts of capsicum.
Preferably, it counts in parts by weight, each component content is, 10-25 parts of Radix Angelicae Sinensis, 5-15 parts of Chinese cassia tree, 5-20 parts of Radix Salviae Miltiorrhizae, red
7-20 parts of flower, 5-25 parts of Asian puccoon, 10-25 parts of capsicum.
It is a further object to provide a kind of methods for the Chinese medicine preparation preparing above-mentioned treatment pernio.
Preparation method is as described below：
(1) by 10-30 parts of Radix Angelicae Sinensis, 5-25 parts of Chinese cassia tree, 5-35 parts of Radix Salviae Miltiorrhizae, 5-20 parts of safflower, 5-30 parts of Asian puccoon, capsicum 10-
35 parts of first clean, segments, after adding 10-12 times of purified water to impregnate 30-45 minutes, heating is boiled 60-120 minutes, filtering extraction,
Obtain an extracting solution；
(2) dregs of a decoction in step (1) are added again 8-10 times of purified water, heating to boil 45-90 minutes, filtering extraction obtains
Secondary raffinate；
(3) after mixing by the extracting solution twice in step (1), (2), it is 1.24- that heating, which is concentrated into density,
1.36g/m3Concentrate.
Preferably, the Chinese medicine preparation for the treatment of pernio of the invention is paste.
Paste preparation method is as described below：
(1) it is that externally used paste is further made in the Chinese medicine preparation, by the concentrate and Tween 80 in above-mentioned steps (3)
1-15 parts, 1-15 parts of triethanolamine, 10-35 parts of glycerine, 0.1-1 parts of ethyl hydroxy benzoate, 5-25 parts of purified water after mixing, as
Heated aqueous is to 75-85 DEG C, by 5-25 parts of hexadecanol, 3-20 parts of stearic acid, 3-20 parts of monoglyceride, 8-25 parts of albolene, liquid
1-15 parts of shape paraffin is heated to 75-85 DEG C as oil phase；
（2）Oil phase in step (1) is poured into the water phase in step (1), after stirring evenly, condensation to body of paste；
（3）By step（2）In body of paste through packing, outsourcing, the externally used paste of 20g/ box -40g/ boxes is made.
Preferably, the paste as described in the above method is prepared, is counted in parts by weight, each auxiliary material component content is 16
5-15 parts of alcohol, 3-15 parts of stearic acid, 3-15 parts of monoglyceride, 8-20 parts of albolene, 2-10 parts of liquid paraffin, Tween 80 2-10
Part, 2-10 parts of triethanolamine, 10-20 parts of glycerine, 0.2-0.8 parts of ethyl hydroxy benzoate, 5-15 parts of purified water.
Principle：Traditional Chinese medicine think the cold dermatoses such as pernio, skin frostbite normally due to cold-evil's external beam and cause part cold
Blood coagulation is stagnant, and QI-blood circulation is unfavorable, and numbness resistance is obstructed to be formed.Therefore it is fixed side to treat such skin disease with promoting blood circulation to remove blood stasis, antalgic
Then.《Book on Chinese herbal medicine is just》Cloud：" Radix Angelicae Sinensis, sweet in flavor and weigh, therefore can specially enrich blood, gas is light and pungent, thus again can promoting circulation of blood, bowl spares has, in row
There is benefit, the gas medicine in sincere blood, the also panacea in blood." event side takes the panacea in blood to arrogate to oneself replenishing and activating blood when being classified as monarch, it is warm-natured
Acrid-sweet flavor, external application are mostly used to control the diseases such as ulcer sores.Product Chinese cassia tree of the minister to warm, the pungent sweet big heat of the medicine, let the fire back to its origin, Wen Jingtong
Arteries and veins, eliminating cold to stop pain.Radix Salviae Miltiorrhizae, safflower are equipped with as adjutant, the former is relieved pain at bitter cold with cool blood to disappear carbuncle, the Eradicates stasis of bloods, and apocenosis myogenic is to arrogate to oneself；The latter
Then slight bitter fragrance, with Eradicates stasis of bloods analgesic of invigorating blood circulation for length, the two assists monarch drug in a prescription cooling and activating blood, relieves pain dispersing blood stasis, helps the quick apocenosis of sore swell and ache curative
Detumescence, analgesic myogenic.It is to make to take the Asian puccoon of cooling and activating blood, and the cold promoting eruption of preferably detoxifying of the pharmacological property, the particularly outer used time is chiefly used in controlling sore carbuncle
Furuncle, the disease that do not close up long of festering.Capsicum is hot, root energy activating blood circulation and reducing swelling, is the normal medicine of external curing pernio, therefore takes it to make
Medicine.
Compared with prior art, the present invention having the following advantages that：
1, promoting blood circulation to remove blood stasis, antalgic, mild in medicine property and.
2, easy to use, curative effect is apparent, cure rate is high, difficulty in relapse after healing.
3, the scar that pernio leaves is dispelled.
Specific implementation mode
The present invention is further described below：
Embodiment 1：
A kind of Chinese medicine preparation for treating pernio, is counted in parts by weight, and each component content is 15 parts of Radix Angelicae Sinensis, 8 parts of Chinese cassia tree, pellet
12 parts of ginseng, 8 parts of safflower, 15 parts of Asian puccoon, 25 parts of capsicum.
Preparation method includes the following steps：(1) by 15 parts of Radix Angelicae Sinensis, 8 parts of Chinese cassia tree, 12 parts of Radix Salviae Miltiorrhizae, 8 parts of safflower, 15 parts of Asian puccoon,
25 parts of capsicum is first cleaned, segment is heated and boiled 60 minutes after adding 12 times of purified water to impregnate 45 minutes, and filtering extraction obtains once
Extracting solution；
(2) dregs of a decoction in step (1) are added again 8 times of purified water, heating to boil 90 minutes, filtering extraction obtains secondary carry
Take liquid；
(3) after mixing by the extracting solution twice in step (1), (2), it is 1.26g/m that heating, which is concentrated into density,3's
Concentrate.
Embodiment 2：
On the basis of embodiment 1, which is further made paste, is included the following steps：（1）By embodiment
0.3 part of 15 parts of 5 parts of 5 parts of concentrate Yu Tween 80, triethanolamine, glycerine, the ethyl hydroxy benzoate of step (3), 8 parts of purified water are mixed in 1
After closing uniformly, as heated aqueous to 85 DEG C, by 10 parts of hexadecanol, 8 parts of stearic acid, 5 parts of monoglyceride, 12 parts of albolene, liquid
2 parts of shape paraffin is heated to 80 DEG C as oil phase；
（2）Oil phase in step (1) is poured into the water phase in step (1), after stirring evenly, condensation to body of paste；
（3）By step（2）In body of paste through packing, outsourcing, the externally used paste of 20g/ boxes is made.
Embodiment 3：
A kind of Chinese medicine preparation for treating pernio, is counted in parts by weight, and each component content is 12 parts of Radix Angelicae Sinensis, 10 parts of Chinese cassia tree, pellet
15 parts of ginseng, 10 parts of safflower, 20 parts of Asian puccoon, 20 parts of capsicum.
Preparation method includes the following steps：(1) by 12 parts of Radix Angelicae Sinensis, 10 parts of Chinese cassia tree, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of safflower, Asian puccoon 20
Part, 20 parts of capsicum are first cleaned, segment is heated and boiled 90 minutes after adding 10 times of purified water to impregnate 30 minutes, and filtering is extracted, and is obtained
Extracting solution；
(2) dregs of a decoction in step (1) are added again 10 times of purified water, heating to boil 45 minutes, filtering extraction obtains secondary carry
Take liquid；
(3) after mixing by the extracting solution twice in step (1), (2), it is 1.29g/m that heating, which is concentrated into density,3's
Concentrate.
Embodiment 4：
On the basis of embodiment 3, which is further made paste, is included the following steps：(1) by embodiment
0.2 part of 18 parts of 2 parts of 3 parts of concentrate Yu Tween 80, triethanolamine, glycerine, the ethyl hydroxy benzoate of step (3), 10 parts of purified water in 3
After mixing, as heated aqueous to 80 DEG C, by 12 parts of hexadecanol, 6 parts of stearic acid, 8 parts of monoglyceride, 10 parts of albolene,
5 parts of liquid paraffin is heated to 85 DEG C as oil phase；
（2）Oil phase in step (1) is poured into the water phase in step (1), after stirring evenly, condensation to body of paste；
（3）By step（2）In body of paste through packing, outsourcing, the externally used paste of 25g/ boxes is made.
Embodiment:5：
A kind of Chinese medicine preparation for treating pernio, is counted in parts by weight, and each component content is 20 parts of Radix Angelicae Sinensis, 6 parts of Chinese cassia tree, pellet
14 parts of ginseng, 6 parts of safflower, 12 parts of Asian puccoon, 18 parts of capsicum.
Preparation method includes the following steps：(1) by 20 parts of Radix Angelicae Sinensis, 6 parts of Chinese cassia tree, 14 parts of Radix Salviae Miltiorrhizae, 6 parts of safflower, 12 parts of Asian puccoon,
18 parts of capsicum first clean, segment, add 11 times purified water impregnate after forty minutes, heating boil 80 minutes, filtering extraction, obtain once
Extracting solution；
(2) dregs of a decoction in step (1) are added again 10 times of purified water, heating to boil 80 minutes, filtering extraction obtains secondary carry
Take liquid；
(3) after mixing by the extracting solution twice in step (1), (2), it is 1.31g/m that heating, which is concentrated into density,3's
Concentrate.
Embodiment 6：
On the basis of embodiment 5, which is further made paste, is included the following steps：(1) by embodiment
0.5 part of 12 parts of 3 parts of 4 parts of concentrate Yu Tween 80, triethanolamine, glycerine, the ethyl hydroxy benzoate of step (3), 12 parts of purified water in 5
After mixing, as heated aqueous to 78 DEG C, by 10 parts of hexadecanol, 10 parts of stearic acid, 10 parts of monoglyceride, albolene 15
Part, 6 parts of liquid paraffin are heated to 75 DEG C as oil phase；
（2）Oil phase in step (1) is poured into the water phase in step (1), after stirring evenly, condensation to body of paste；
（3）By step（2）In body of paste through packing, outsourcing, the externally used paste of 30g/ boxes is made.
Embodiment 7：
A kind of Chinese medicine preparation for treating pernio, is counted in parts by weight, and each component content is 18 parts of Radix Angelicae Sinensis, 5 parts of Chinese cassia tree, pellet
10 parts of ginseng, 5 parts of safflower, 10 parts of Asian puccoon, 15 parts of capsicum.
Preparation method includes the following steps：(1) by 18 parts of Radix Angelicae Sinensis, 5 parts of Chinese cassia tree, 10 parts of Radix Salviae Miltiorrhizae, 5 parts of safflower, 10 parts of Asian puccoon,
15 parts of capsicum is first cleaned, segment is heated and boiled 60-120 minutes, filtering carries after adding 12 times of purified water to impregnate 30-45 minutes
It takes, obtains an extracting solution；
(2) dregs of a decoction in step (1) are added again 9 times of purified water, heating to boil 45-90 minutes, filtering extraction obtains secondary
Extracting solution；
(3) after mixing by the extracting solution twice in step (1), (2), it is 1.35g/m that heating, which is concentrated into density,3's
Concentrate.
Embodiment 8：
On the basis of embodiment 7, which is further made paste, is included the following steps：(1) by embodiment
0.4 part of 18 parts of 6 parts of 2 parts of concentrate Yu Tween 80, triethanolamine, glycerine, the ethyl hydroxy benzoate of step (3), 5 parts of purified water are mixed in 7
After closing uniformly, as heated aqueous to 75 DEG C, by 6 parts of hexadecanol, 12 parts of stearic acid, 3 parts of monoglyceride, 8 parts of albolene, liquid
4 parts of paraffin is heated to 78 DEG C as oil phase；
（2）Oil phase in step (1) is poured into the water phase in step (1), after stirring evenly, condensation to body of paste；
（3）By step（2）In body of paste through packing, outsourcing, the externally used paste of 40g/ boxes is made.
Clinical test：
Case 1：Jiang, female 43 years old, suffer from habitual pernio for many years, whenever winter both hands, both feet all have different degrees of length
Pernio, both hands pernio are particularly acute, and are festered, are itched pain unbearably, in the chilblain medicine of the coating present invention in 2007, once a day, one
After the course for the treatment of, ulcer, pain of itching are substantially reduced, continue after smearing a course for the treatment of, cure, and pay a return visit within subsequent 2 years pernio without recurrence.
Case 2：Lee, female 19 years old, suffer from I degree pernio 3 years, whenever winter both hands, both feet, two cheeks all can long pernio, two
Cheek pernio is particularly acute, and red and swollen, itch unbearably, in 2010 applies chilblain medicine of the invention, once a day, the half course for the treatment of
Afterwards, it cures, pays a return visit within subsequent 2 years pernio without recurrence.
Case 3：Xiong, man, 55 years old, II degree pernio of the biped with seeing about 3cm × 4cm, it is red and swollen, swollen, ache, itch obviously.
In the chilblain medicine of the coating present invention in 2014, twice a day, after the half course for the treatment of, symptom is substantially reduced, then once a day,
Continue after smearing a course for the treatment of, cure, pays a return visit within subsequent 3 years pernio without recurrence.
Clinical observation the result shows that：2007 so far hospital accept the pernio patients up to 1327 of different extents for medical treatment
Example carries out clinical observation treatment, 12 to 70 years old ages, medication 3 to 12 times, only a few patient to wherein 352 pernio patients
Medication is more than 15 times or more, and cure rate 92%, remaining symptom is all also reduced to varying degrees；In all recovery from illness patients, second year
56 people are recurred, recurrence rate 15.9%.
Above-described embodiment is only to be illustrated to technical scheme of the present invention, the limitation not made to the present invention.Appoint
The modification and equivalent replacement what makes technical scheme of the present invention, belong to the protection domain of technical scheme of the present invention.
Claims (10)
1. a kind of Chinese medicine preparation for treating pernio, it is characterised in that：It counts and is made of following raw materials in parts by weight：Radix Angelicae Sinensis 10-30
Part, 5-25 parts of Chinese cassia tree, 5-35 parts of Radix Salviae Miltiorrhizae, 5-20 parts of safflower, 5-30 parts of Asian puccoon, 10-35 parts of capsicum.
2. the Chinese medicine preparation for the treatment of pernio according to claim 1, it is characterised in that：It is counted in parts by weight by following raw materials
It is made：10-25 parts of Radix Angelicae Sinensis, 5-15 parts of Chinese cassia tree, 5-20 parts of Radix Salviae Miltiorrhizae, 7-20 parts of safflower, 5-25 parts of Asian puccoon, 10-25 parts of capsicum.
3. the Chinese medicine preparation for the treatment of pernio according to claim 1 or 2, it is characterised in that：It is counted in parts by weight by following
Raw material is made：15 parts of Radix Angelicae Sinensis, 8 parts of Chinese cassia tree, 12 parts of Radix Salviae Miltiorrhizae, 8 parts of safflower, 15 parts of Asian puccoon, 25 parts of capsicum.
4. the Chinese medicine preparation for the treatment of pernio according to claim 1 or 2, it is characterised in that：It is counted in parts by weight by following
Raw material is made：12 parts of Radix Angelicae Sinensis, 10 parts of Chinese cassia tree, 15 parts of Radix Salviae Miltiorrhizae, 10 parts of safflower, 20 parts of Asian puccoon, 20 parts of capsicum.
5. the Chinese medicine preparation for the treatment of pernio according to claim 1 or 2, it is characterised in that：It is counted in parts by weight by following
Raw material is made：20 parts of Radix Angelicae Sinensis, 6 parts of Chinese cassia tree, 14 parts of Radix Salviae Miltiorrhizae, 6 parts of safflower, 12 parts of Asian puccoon, 18 parts of capsicum.
6. the Chinese medicine preparation for the treatment of pernio according to claim 1 or 2, it is characterised in that：It is counted in parts by weight by following
Raw material is made：18 parts of Radix Angelicae Sinensis, 5 parts of Chinese cassia tree, 10 parts of Radix Salviae Miltiorrhizae, 5 parts of safflower, 10 parts of Asian puccoon, 15 parts of capsicum.
7. the method for preparing the Chinese medicine preparation for the treatment of pernio as described in claim 1, it is characterised in that：Include the following steps：
(1) 10-30 parts of Radix Angelicae Sinensis, 5-25 parts of Chinese cassia tree, 5-35 parts of Radix Salviae Miltiorrhizae, 5-20 parts of safflower, 5-30 parts of Asian puccoon, 10-35 parts of capsicum are first washed
Only, segment, after adding 10-12 times of purified water to impregnate 30-45 minutes, heating is boiled 60-120 minutes, and filtering extraction is obtained and once carried
Take liquid；
(2) dregs of a decoction in step (1) are added again 8-10 times of purified water, heating to boil 45-90 minutes, filtering extraction obtains secondary
Extracting solution；
(3) after mixing by the extracting solution twice in step (1), (2), it is 1.24-1.36g/m that heating, which is concentrated into density,3's
Concentrate.
8. the Chinese medicine preparation for the treatment of pernio according to claim 1 or 2, it is characterised in that：The Chinese medicine preparation is paste.
9. the Chinese medicine preparation for the treatment of pernio according to claim 8, it is characterised in that：Further include auxiliary in addition to the raw material
Material, is counted, each auxiliary material component content is 5-25 parts of hexadecanol, 3-20 parts of stearic acid, 3-20 parts of monoglyceride, Bai Fan in parts by weight
8-25 parts of intellectual circle, 1-15 parts of liquid paraffin, 1-15 parts of Tween 80,1-15 parts of triethanolamine, 10-35 parts of glycerine, ethyl hydroxy benzoate
0.1-1 parts, 5-25 parts of purified water.
10. the method for preparing the paste of the Chinese medicine preparation for the treatment of pernio as claimed in claim 8, it is characterised in that：Including with
Lower step：(1) by 10-30 parts of Radix Angelicae Sinensis, 5-25 parts of Chinese cassia tree, 5-35 parts of Radix Salviae Miltiorrhizae, 5-20 parts of safflower, 5-30 parts of Asian puccoon, capsicum 10-35
Part is first cleaned, segment is heated and boiled 60-120 minutes after adding 10-12 times of purified water to impregnate 30-45 minutes, and filtering extraction obtains
Extracting solution；
(2) dregs of a decoction in step (1) are added again 8-10 times of purified water, heating to boil 45-90 minutes, filtering extraction obtains secondary
Extracting solution；
(3) after mixing by the extracting solution twice in step (1), (2), it is 1.24-1.36g/m that heating, which is concentrated into density,3's
Concentrate；
(4) externally used paste is further made in the Chinese traditional medicine composition, also need by step (3) 1-15 parts of concentrate and Tween 80,
1-15 parts of triethanolamine, 10-35 parts of glycerine, 0.1-1 parts of ethyl hydroxy benzoate, 5-25 parts of purified water after mixing, as water phase plus
Heat is to 75-85 DEG C, by 5-25 parts of hexadecanol, 3-20 parts of stearic acid, 3-20 parts of monoglyceride, 8-25 parts of albolene, liquid paraffin
1-15 parts as oil phase are heated to 75-85 DEG C；
（5）Oil phase in step (4) is poured into the water phase in step (4), after stirring evenly, condensation to body of paste；
（6）By step（5）In body of paste through packing, outsourcing, the externally used paste of 20g/ box -40g/ boxes is made.
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| CN201510067953.4A CN104666596B (en) | 2015-02-10 | 2015-02-10 | A kind of Chinese medicine preparation and preparation method thereof for treating pernio |
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| CN113384519A (en) * | 2021-04-21 | 2021-09-14 | 北京圣永制药有限公司 | Formula and preparation method of chilblain cream |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839984A (en) * | 2006-01-05 | 2006-10-04 | 袁安龙 | Externally applied Chinese medicinal aqueous formulation for treating kibe |
| CN103893052A (en) * | 2012-12-29 | 2014-07-02 | 张涛 | Cosmetic for preventing and treating cold injury |
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2015
- 2015-02-10 CN CN201510067953.4A patent/CN104666596B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839984A (en) * | 2006-01-05 | 2006-10-04 | 袁安龙 | Externally applied Chinese medicinal aqueous formulation for treating kibe |
| CN103893052A (en) * | 2012-12-29 | 2014-07-02 | 张涛 | Cosmetic for preventing and treating cold injury |
Non-Patent Citations (2)
| Title |
|---|
| 中医药治疗冻伤的研究;刘义梅等;《中南民族大学学报（自然科学版）》;20130930;第32卷(第3期);第41-46页 * |
| 消肿酊治疗冻疮154例;曾冲;《国医论坛》;19971231;第12卷(第2期);第39页 * |
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