CN104666145B - A kind of Chinese herbal medicine and its application in cosmetics for ultraviolet injury repair and promotion energetic supersession - Google Patents
A kind of Chinese herbal medicine and its application in cosmetics for ultraviolet injury repair and promotion energetic supersession Download PDFInfo
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- CN104666145B CN104666145B CN201310625970.6A CN201310625970A CN104666145B CN 104666145 B CN104666145 B CN 104666145B CN 201310625970 A CN201310625970 A CN 201310625970A CN 104666145 B CN104666145 B CN 104666145B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/004—Aftersun preparations
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Abstract
The invention discloses a kind of Chinese herbal medicines and its application in cosmetics for ultraviolet injury repair and promotion energetic supersession.Specifically, the invention discloses loquat-leaf extracts in ultraviolet injury repair and to promote the purposes of purposes and loquat-leaf extract as the additive with ultraviolet injury repair and promotion energetic supersession effect in cosmetics in energetic supersession.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine with ultraviolet injury repair and promotion energetic supersession effect and its in cosmetics
In application, and in particular to loquat-leaf extract and its application in cosmetics.
Background technology
Ultraviolet light not only destroys outermost Skin Cell, while can also lead to dermal cell necrosis and metabolic disorder,
Intracellular impurity can not be metabolized away, and skin is enabled sunburn occur, lose elasticity, and aging ahead of time becomes sensitive, wrinkle occurs, and
And shouting pain itch unbearably, scratches bleeding after skin injury, the disease-resistant and resistivity of skin itself weakens or even oedema, exudation,
Epifolliculitis is formed, furuncle etc. is difficult to the skin disease cured.
Have at present to the mechanism understanding of skin injury to ultraviolet light：Oxidative stress, inflammatory reaction, Apoptosis, collagen and
The degradation of elastin laminin.Skin receives excessive ultraviolet light irradiation, and skin tissue cell will produce oxidative stress, generate excessive
Reactive oxygen species ROS destroys the integrality of cell membrane and intracellular antioxidant system, further causes cellular inflammation, cell withers
It dies and the formation of tumour.Excessive ultraviolet light irradiation makes skin collagen, hyaluronic acid, elastin degradation simultaneously, leads to skin
Elastic deformation, coarse, formation wrinkle.Therefore, for the restorative procedure after ultraviolet injury made from these mechanism mostly
With with substance that is anti-oxidant, anti-inflammatory, inhibiting matrix metalloproteinase effect.Such as Chinese ash extract effectively removes UVB
The a large amount of free radicals generated in irradiation descendant's Fb cells, reduce the expression of the mRNA and albumen of MMP-1, to fight UVB irradiations
Skin injury afterwards；For another example contain bata-carotene in marigold flower extract, by inhibiting hyaluronidase, elastin laminin
The activity of enzyme, MMP-1 inhibits wrinkle to generate, to play the role of ultraviolet protection.
ATP is the key molecule of cellular energy metabolism, is the primary energy source that Skin Cell can be used directly,
It is an important indicator of reacting cells health vigor, the reduction of ATP causes the decrease of energetic supersession, body that can go out accordingly
Existing functional decline, most significantly no more than skin aging, obscure acne etc..New research finds the strong photograph of ultraviolet light
It penetrates, ATP can be caused to generate and reduced, lead to the decrease of energetic supersession, influence Skin Cell normal function.Therefore ATP promotes damage
The increase of cell can promote cellular energy metabolic afterwards, and skin injury caused by be conducive to ultraviolet light irradiation is repaiied
It is multiple.
Loguat leaf is rosaceous plant loquat Eriobotrya japonica（Thunb.）Lindl. leaf.It is commonly used to clear
Lung cough-relieving, stopping nausea and vomiting by lowering the adverse flow of QI.Dry can be treated to quench one's thirst, lung wind face sore, acne.It is preferable that modern pharmacological research report confirms that it has
Anti-inflammatory, antibacterial and antitussive action are frequently used for treatment acne and remove acne cosmeceutical.
The prior art points out that skin, which is chronically exposed under ultraviolet light, can cause skin injury, skin photoage occurs very
To there is skin canceration and other cutaneous lesions.The main mechanism of UV-induced skin photoage has：Oxidative stress, inflammation
Reaction, the degradation etc. of Apoptosis, collagen and elastin laminin.Focus of attention is exploitation ultra-violet protecting agent both at home and abroad at present,
That mainly studies at present has flavone compound, terpenoid, tannin class and Coumarins etc..But existing document report
Road, which is not mentioned, promotes energetic supersession and the synthesis of ATP that can also be repaired to UVB.
Patent document 201110250949.3, which discloses, a kind for the treatment of cough foot-bath traditional Chinese medicine composition.Specifically, the document
Disclose a kind of foot-bath traditional Chinese medicine composition for treating flu, including asarum, cassia twig, cloves, myrrh, loguat leaf, cymose buckwheat rhizome, Chinese herbaceous peony
Grass, evodia rutaecarpa, ramulus mori, cat gas rattan, Rhizoma Et Radix Notopterygii, sealwort, ching-chieh, Rhizoma Atractylodis Macrocephalae, Chinese ephedra, Chinese cassia tree, Radix Astragali.Work(with clearing and activating the channels and collaterals
Can, metabolism is effectively facilitated, blood circulation is increased, enhances the basic constitution of human body, effectively treats flu.But the patent
For a kind of composition, and proves that loguat leaf single medicinal material has without evidence and promote energetic supersession effect.
Patent document 200810048647.6 discloses a kind of with the treatment acne of antianaphylaxis function and its medicine of scar
It applies some make up.Specifically, the document is related to a kind of with the treatment acne of antianaphylaxis function and the cosmeceutical of scar.Its at
Divide and is made of honeysuckle, onion, loguat leaf, the tuber of stemona, centella, Radix Salviae Miltiorrhizae, VC.Preparation method include boil carry, liquid concentration, preparation
Several steps such as molding.The patent application is an anti-allergic effects of the loguat leaf prescription in cosmeceutical, is wrapped simultaneously
Preparation method has been included, has not mentioned energetic supersession.
It can be seen that the prior art does not refer to loguat leaf in terms of the reparation of UVB irradiation damages and promoting energetic supersession
Effect.Present invention firstly discovers that loquat-leaf extract has ultraviolet injury repair and promotes the property in terms of Skin Cell energetic supersession
Matter.
Invention content
Present invention aims at provide a kind of Chinese herbal medicine extraction with ultraviolet injury repair and promotion cellular energy metabolism
Object, the Chinese herbal medicine extract can promote ATP to synthesize, and ultraviolet injury is repaired caused by UVB.At the same time as effect
Additive is added in cosmetics and uses, for ultraviolet injury repair and the supplement of Skin Cell energy.
Loguat leaf extraction process flow is as follows：
Loguat leaf medicinal material is micro- broken, about 0.5-1h is impregnated with appropriate vehicle, is extracted with correlation method, filters, takes filtrate dense
It is reduced to 1 times or so of medicinal material total amount（V/W）, the solution of the 0.5-2g/ml containing crude drug amount is made.
Chinese medicine proportionally can be zoomed in or out suitably in formula；Appropriate vehicle includes water（Distilled water, deionized water,
Pure water）, the ethanol solution of various concentration, the polyhydric alcohol solutions of various concentration and the similar solvent of other polarity；Extraction side
Method can be the methods of decoction, refluxing extraction, dipping, diacolation etc..
Producing for loquat-leaf extract can also take supercritical extract, subcritical abstraction, organic solvent extraction.It is organic molten
The solvent of agent extraction includes low polar solvent and various concentration in n-hexane, ethyl acetate, ether, petroleum ether, acetone etc.
Ethyl alcohol, methanol and polyalcohol etc..Extracting method can be the methods of refluxing extraction, dipping, diacolation.Moreover, in extraction process
The method that ultrasound or microwave can also be used is assisted.
In a first aspect, the purposes the present invention relates to loquat-leaf extract in ultraviolet injury repair and in promoting energetic supersession.
Second aspect is used as with ultraviolet injury repair the present invention relates to loquat-leaf extract and promotes energetic supersession effect
Purposes of the additive in cosmetics.
In one embodiment, the dosage of loquat-leaf extract is in 0.00001-100 weight %.In another embodiment party
In formula, the dosage of loquat-leaf extract is in 0.0001-50 weight %.In a preferred embodiment, the dosage of loquat-leaf extract
For 0.001%-20 weight %.
The cosmetics of the present invention are selected from：Mildy wash, toner, lotion, cream, gel, facial mask.In an embodiment
In, toiletry bag of the invention contains loquat-leaf extract and acceptable auxiliary material.
In one embodiment, the loquat-leaf extract of toiletry bag weight containing 0.00001-100 %.In another reality
It applies in mode, the loquat-leaf extract of toiletry bag weight containing 0.0001-50 %.In another embodiment, toiletry bag contains
The loquat-leaf extract of 0.001%-20 weight %.
Description of the drawings
Fig. 1 shows the ATP contents of the loquat-leaf extract of the present invention of normal cell, UV irradiating cells and various concentration
Percentage.In figure, # indicates that there were significant differences for UVB irradiation groups relative to normal group；* indicate, relative to UVB irradiation groups, have aobvious
Write difference（p<0.05).
Specific implementation mode
At present for after ultraviolet injury repair mostly from oxidative stress, the reparation of DNA, inflammatory reaction, Apoptosis,
The degradation of collagen and elastin laminin is angularly set out, and corresponding solution is provided.There has been no proposed from ATP energetic supersession angles
The solution of ultraviolet injury reparation.There is ultraviolet injury repair present invention firstly provides loguat leaf and promote energetic supersession
Effect.Cellular energy loss after loquat-leaf extract provided by the invention can irradiate UVB is repaired, and promotes skin thin
The synthesis of born of the same parents' energetic supersession and ATP, to be conducive to ultraviolet injury repair.
The present inventor have passed through extensively and found after in-depth study：Loquat-leaf extract has ultraviolet damage
Energetic supersession effect is repaired and promoted to wound.
Therefore, loquat-leaf extract can be used as functional additive and be added in cosmetics.
It is not directed to loquat-leaf extract in document with ultraviolet injury repair and promotes energetic supersession effect, does not also refer to
It is added in cosmetics as functional additive.Therefore, present invention firstly provides loquat-leaf extracts, and there is ultraviolet damage to repair
Multiple and promotion energetic supersession effect, can be used as functional additive to be added in cosmetics, thin for ultraviolet injury repair and skin
The supplement of born of the same parents' energy.
In cosmetic applications, loquat-leaf extract can be various forms.For example, loquat-leaf extract application form can
To be any dosage form that can be applied to human skin such as mildy wash, toner, lotion, cream, gel, facial mask.
Other compositions other than loquat-leaf extract can be any ingredient that cosmetic formulations need, such as：Water, ethyl alcohol,
Butanediol, propylene glycol, grease, emulsifier, thickener, preservative etc.；Other functional components can also be added and reach complex function,
Such as：Addition sun-prevention component, which becomes, promotes energetic supersession sun care preparations, and addition oil-control ingredient, which becomes, promotes energetic supersession control
Oiling cosmetic, addition moisturizing ingredient, which becomes, promotes energetic supersession moisture-keeping cosmetics, and addition whitening composition, which becomes, promotes energy generation
Thank to skin-lightening cosmetic, addition aging ingredient, which becomes, promotes energetic supersession anti-aging cosmetics etc..
In general, the use concentration of loquat-leaf extract can be in 0.00001-100 weight %.Preferably, loguat leaf carries
Take the use concentration of object can be in 0.0001-50 weight %.In an embodiment of the invention, loquat-leaf extract makes
With concentration in 0.00001-100 weight %.In another embodiment, the concentration of loquat-leaf extract is in 0.001-50 weights
Measure %.In one embodiment, a concentration of 0.001-20 weight % of the use of loquat-leaf extract.
Loquat-leaf extract can be added to according to the ratio of 0.00001-100 weight % in various cosmetics.For example, Pi
The dosage of rake leaf extract can be 0.00001-25 weight %, such as 0.0001-50 weight %, such as 0.001-75 weight %, example
Such as 0.1-100 weight %.In one preferred embodiment, the dosage of loquat-leaf extract is 0.0001-50 weights in cosmetics
Measure %.In another preferred embodiment, the dosage of loquat-leaf extract is 0.001-20 weight % in cosmetics.
With reference to specific embodiment, the present invention is further explained.It should be appreciated, however, that these embodiments are only used for
It is bright the present invention and be not meant to limit the scope of the invention.The test method of actual conditions is not specified in the following example, usually
According to normal condition, or according to the normal condition proposed by manufacturer.Unless otherwise indicated, all percentage and number be by weight
Meter.
Embodiment 1：Skin Cell Energy Damage reparative experiment caused by loguat leaf irradiates UVB
It is prepared by laboratory sample：
Loguat leaf Chinese medicine 200g is taken, it is micro- broken, add 15 times of deionization water boiling and extraction 1h, filtering and concentrating to 1 times of crude drug amount,
95% ethyl alcohol is added to final concentration of 70%, stands overnight, filters, filtrate is concentrated and dried to obtain loquat-leaf extract.
Precision weighs 0.1g loquat-leaf extracts, and 10mg/ml loquat leaf extracts are obtained with 10ml deionized water dissolvings, uses
PBS buffer solution is diluted to 10ug/ml, 1ug/ml, obtains sample solution.
Experimental method：
1）Cell recovery when to be grown in good condition, carries out cell synchronization processing.
2）Concentration is adjusted after synchronization to be inoculated in cell plates.It second day, is placed under UVB irradiation units, adds normal
Culture medium and culture medium containing embodiment extract continue culture and are incubated.
3）After being incubated after a period of time, test fluid in kit is added per hole, concussion is placed at room temperature for stable fluorescence, instrument
Device detection reading.
Experimental result：
The flat fluorescent RLU that each hole measures is recorded, every group of 3 multiple holes are averaged, and experimental result carries out t inspections, P<
0.05, indicate significant difference；p<0.01 indicates difference highly significant.Meanwhile on the basis of normal cell 100%, it is glimmering to calculate each group
Light unit ATP percentage composition numerical value.
The result shows that：Loquat-leaf extract has ultraviolet injury repair and promotes cellular energy metabolism effect.Even if low
Under concentration (for example, under concentration of 10ug/ml), loquat-leaf extract to after UVB ultraviolet irradiations cellular energy loss have compared with
Good repair promotes the synthesis of ATP, maintains Skin Cell energetic supersession horizontal.As shown in table 1 and Fig. 1, in 10ug/ml
Low dosage concentration under can reach nearly 20% repair rate.
Table 1：The ultraviolet injury repair of loquat-leaf extract acts on
| Loguat leaf extract concentration | Protection ratio（%） |
| 10ug/ml | 15.77% |
| 1ug/ml | 18.26% |
Embodiment 2：Promote the preparation of energetic supersession anti-aging cream
The promotion energetic supersession anti-aging for including loquat-leaf extract of the present invention is prepared according to the ingredient and dosage of table 2
Cream.
Table 2
| Ingredient | % concentration（Weight） |
| Loquat-leaf extract | 1.0 |
| Glyceryl stearate citrate | 4.0 |
| Stearine | 2.0 |
| Cetostearyl alcohol | 2.0 |
| Mineral oil | 10.0 |
| Caprylic/capric triglyceride | 5.0 |
| 1,3 butylene glycol | 7.0 |
| Preservative, essence | In right amount |
| Water | To 100.0 |
Preparation method：Loquat-leaf extract first is dissolved with 1,3-BDO, is then added in water, stirs evenly, obtain
Water phase.By Glyceryl stearate citrate, stearine, cetostearyl alcohol, caprylic/capric triglyceride, mineral oil
It is added in oil phase pot, is heated to 75 DEG C -80 DEG C, stirs evenly, obtain oil phase.Oil phase is slowly added in water phase, does not stop to stir
Mix, uniformly after preservative and essence is added, stir evenly to get.
Embodiment 3：Promote the preparation of energetic supersession moisture retention water
The promotion energetic supersession moisturizing for including loquat-leaf extract of the present invention is prepared according to the ingredient and dosage of table 3
Water.
Table 3
| Ingredient | % concentration（Weight） |
| Loquat-leaf extract | 2.0 |
| 1,3-BDO | 8.0 |
| Preservative, soluble perfume | In right amount |
| Water | To 100 |
Preparation method：Loquat-leaf extract first is dissolved with 1,3-BDO, is then added in water, is stirred, it is uniformly rear to add
Enter preservative and essence, stir evenly to get.
Claims (10)
1. purposes of the loquat-leaf extract of non-treatment purpose in ultraviolet injury repair, wherein the loquat-leaf extract is
With water boiling and extraction.
2. purposes of the loquat-leaf extract as the additive with ultraviolet injury repair effect in cosmetics, wherein described
Loquat-leaf extract water boiling and extraction.
3. purposes as claimed in claim 1 or 2, which is characterized in that the dosage of the loquat-leaf extract comprising
0.00001-100 weight %.
4. purposes as claimed in claim 1 or 2, which is characterized in that the dosage of the loquat-leaf extract is including 0.0001-
50 weight %.
5. purposes as claimed in claim 1 or 2, which is characterized in that the dosage of the loquat-leaf extract includes 0.001-20
Weight %.
6. purposes as claimed in claim 2, which is characterized in that the cosmetics are selected from：Mildy wash, toner, lotion, cream
Frost, gel, facial mask.
7. purposes as claimed in claim 6, which is characterized in that the toiletry bag is containing loquat-leaf extract and acceptable
Auxiliary material.
8. purposes as claimed in claim 6, which is characterized in that the loquat of toiletry bag weight containing the 0.00001-100 %
Leaf extract.
9. purposes as claimed in claim 6, which is characterized in that the loguat leaf of toiletry bag weight containing the 0.0001-50 %
Extract.
10. purposes as claimed in claim 6, which is characterized in that the loguat leaf of toiletry bag weight containing the 0.001-20 %
Extract.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310625970.6A CN104666145B (en) | 2013-11-28 | 2013-11-28 | A kind of Chinese herbal medicine and its application in cosmetics for ultraviolet injury repair and promotion energetic supersession |
| PCT/CN2014/092433 WO2015078397A1 (en) | 2013-11-28 | 2014-11-28 | Chinese herbal medicine for repairing ultraviolet damage and promoting energy metabolism, and uses thereof in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310625970.6A CN104666145B (en) | 2013-11-28 | 2013-11-28 | A kind of Chinese herbal medicine and its application in cosmetics for ultraviolet injury repair and promotion energetic supersession |
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| Publication Number | Publication Date |
|---|---|
| CN104666145A CN104666145A (en) | 2015-06-03 |
| CN104666145B true CN104666145B (en) | 2018-09-04 |
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| CN201310625970.6A Active CN104666145B (en) | 2013-11-28 | 2013-11-28 | A kind of Chinese herbal medicine and its application in cosmetics for ultraviolet injury repair and promotion energetic supersession |
Country Status (2)
| Country | Link |
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| CN (1) | CN104666145B (en) |
| WO (1) | WO2015078397A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106176377B (en) * | 2016-08-08 | 2019-03-05 | 珀莱雅化妆品股份有限公司 | A kind of sun-proof synergistic composition of plant origin and preparation method thereof |
| KR102212667B1 (en) | 2018-03-19 | 2021-02-05 | 스푸라우트 코포레이션 리미티드 | Extract of plant, preparation method and use thereof, and cosmeceutical and product comprising extract of plant |
| CN108703936A (en) * | 2018-07-17 | 2018-10-26 | 佛山市三水区嘉华化学研究院（普通合伙） | A kind of anti-aging facial mask of Radix et Rhizoma Gynurae divaricatae and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955083A (en) * | 1996-01-03 | 1999-09-21 | Lvmh Recherche | Use of eriobotrya japonica extract, in particular in cosmetics for stimulating glycosaminoglycan synthesis |
| CN101279996A (en) * | 2007-04-04 | 2008-10-08 | 研光通商株式会社 | Process for preparing high purity corosolic acid and high purity ursolic acid |
| CN103110558A (en) * | 2011-11-16 | 2013-05-22 | 毛雪莲 | Wrinkle resisting and brightening algal mask and its preparation method |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62249907A (en) * | 1986-04-22 | 1987-10-30 | Eikoudou:Kk | Cosmetic |
| JP4789334B2 (en) * | 2001-03-01 | 2011-10-12 | ポーラ化成工業株式会社 | Skin preparation for wrinkle improvement and prevention |
| KR100684776B1 (en) * | 2004-03-09 | 2007-02-22 | 주식회사 한생화장품 | Cosmetic composition comprising extract of Eriobotrya japonica L. for improving wrinkle |
| CN102293724B (en) * | 2011-08-05 | 2012-11-07 | 广东南方洁灵科技实业有限公司 | Cosmetic composition containing Chinese herbal compounds |
| CN103027867A (en) * | 2011-09-30 | 2013-04-10 | 天津市中科健新材料技术有限公司 | Finishing liquor applied on wet tissue and available for after-sun makeup removal and repair |
-
2013
- 2013-11-28 CN CN201310625970.6A patent/CN104666145B/en active Active
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2014
- 2014-11-28 WO PCT/CN2014/092433 patent/WO2015078397A1/en active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5955083A (en) * | 1996-01-03 | 1999-09-21 | Lvmh Recherche | Use of eriobotrya japonica extract, in particular in cosmetics for stimulating glycosaminoglycan synthesis |
| CN101279996A (en) * | 2007-04-04 | 2008-10-08 | 研光通商株式会社 | Process for preparing high purity corosolic acid and high purity ursolic acid |
| CN103110558A (en) * | 2011-11-16 | 2013-05-22 | 毛雪莲 | Wrinkle resisting and brightening algal mask and its preparation method |
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| Publication number | Publication date |
|---|---|
| WO2015078397A1 (en) | 2015-06-04 |
| CN104666145A (en) | 2015-06-03 |
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