CN104661996A - Ioforminol的中间体化合物的制备 - Google Patents

Ioforminol的中间体化合物的制备 Download PDF

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Publication number
CN104661996A
CN104661996A CN201380050455.8A CN201380050455A CN104661996A CN 104661996 A CN104661996 A CN 104661996A CN 201380050455 A CN201380050455 A CN 201380050455A CN 104661996 A CN104661996 A CN 104661996A
Authority
CN
China
Prior art keywords
compound
preparation
bis
ioforminol
short chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380050455.8A
Other languages
English (en)
Chinese (zh)
Inventor
M.萨宁
A.奥尔松
C.格罗加德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
GE Healthcare AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare AS filed Critical GE Healthcare AS
Priority to CN201910145184.3A priority Critical patent/CN110003038A/zh
Publication of CN104661996A publication Critical patent/CN104661996A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
CN201380050455.8A 2012-09-27 2013-09-17 Ioforminol的中间体化合物的制备 Pending CN104661996A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910145184.3A CN110003038A (zh) 2012-09-27 2013-09-17 Ioforminol的中间体化合物的制备

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20121102 2012-09-27
NO20121102 2012-09-27
PCT/US2013/060081 WO2014052091A1 (en) 2012-09-27 2013-09-17 Preparation of an intermediate compound of ioforminol

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910145184.3A Division CN110003038A (zh) 2012-09-27 2013-09-17 Ioforminol的中间体化合物的制备

Publications (1)

Publication Number Publication Date
CN104661996A true CN104661996A (zh) 2015-05-27

Family

ID=49274871

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910145184.3A Pending CN110003038A (zh) 2012-09-27 2013-09-17 Ioforminol的中间体化合物的制备
CN201380050455.8A Pending CN104661996A (zh) 2012-09-27 2013-09-17 Ioforminol的中间体化合物的制备

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201910145184.3A Pending CN110003038A (zh) 2012-09-27 2013-09-17 Ioforminol的中间体化合物的制备

Country Status (12)

Country Link
US (1) US9884808B2 (enExample)
EP (1) EP2900632B1 (enExample)
JP (1) JP6431842B2 (enExample)
KR (1) KR20150061635A (enExample)
CN (2) CN110003038A (enExample)
AU (1) AU2013323981B2 (enExample)
BR (1) BR112015004591A2 (enExample)
CA (1) CA2881852A1 (enExample)
IN (1) IN2015DN01185A (enExample)
MX (1) MX354604B (enExample)
RU (1) RU2654461C2 (enExample)
WO (1) WO2014052091A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9884808B2 (en) 2012-09-27 2018-02-06 Ge Healthcare As Preparation of an intermediate compound of ioforminol

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047549A1 (en) * 1999-02-11 2000-08-17 Nycomed Imaging As Preparation of iodixanol
CN101233092A (zh) * 2005-07-29 2008-07-30 通用电气医疗集团股份有限公司 碘化苯基衍生物的连续结晶方法
CN101687051A (zh) * 2007-07-12 2010-03-31 通用电气医疗集团股份有限公司 造影剂
CN101962342A (zh) * 2009-07-21 2011-02-02 通用电气医疗集团股份有限公司 非离子x射线造影剂的合成中的连续脱乙酰化和纯化工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO161368C (no) 1982-11-08 1989-08-09 Nyegaard & Co As Roentgenkontrastmidler samt radiologiske preparater derav.
AU6114396A (en) * 1995-06-16 1997-01-15 Biophysica Foundation Formyl derivatives as nonionic contrast media
GB9624612D0 (en) 1996-11-26 1997-01-15 Nycomed Imaging As Process
NO20043305D0 (no) 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
BR112015004580A2 (pt) * 2012-09-27 2017-07-04 Ge Healthcare As processo para a preparação de um composto, composto, e, composição
US9884808B2 (en) 2012-09-27 2018-02-06 Ge Healthcare As Preparation of an intermediate compound of ioforminol

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000047549A1 (en) * 1999-02-11 2000-08-17 Nycomed Imaging As Preparation of iodixanol
CN101233092A (zh) * 2005-07-29 2008-07-30 通用电气医疗集团股份有限公司 碘化苯基衍生物的连续结晶方法
CN101687051A (zh) * 2007-07-12 2010-03-31 通用电气医疗集团股份有限公司 造影剂
CN101962342A (zh) * 2009-07-21 2011-02-02 通用电气医疗集团股份有限公司 非离子x射线造影剂的合成中的连续脱乙酰化和纯化工艺

Also Published As

Publication number Publication date
MX2015003912A (es) 2015-08-05
AU2013323981B2 (en) 2017-09-14
JP2015532280A (ja) 2015-11-09
MX354604B (es) 2018-03-07
AU2013323981A1 (en) 2015-03-05
US20150246871A1 (en) 2015-09-03
RU2654461C2 (ru) 2018-05-18
EP2900632B1 (en) 2019-10-30
EP2900632A1 (en) 2015-08-05
BR112015004591A2 (pt) 2017-07-04
US9884808B2 (en) 2018-02-06
CA2881852A1 (en) 2014-04-03
WO2014052091A1 (en) 2014-04-03
RU2015107016A (ru) 2016-11-20
IN2015DN01185A (enExample) 2015-06-26
KR20150061635A (ko) 2015-06-04
CN110003038A (zh) 2019-07-12
JP6431842B2 (ja) 2018-11-28

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
EXSB Decision made by sipo to initiate substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20150527