IN2015DN01185A - - Google Patents

Info

Publication number
IN2015DN01185A
IN2015DN01185A IN1185DEN2015A IN2015DN01185A IN 2015DN01185 A IN2015DN01185 A IN 2015DN01185A IN 1185DEN2015 A IN1185DEN2015 A IN 1185DEN2015A IN 2015DN01185 A IN2015DN01185 A IN 2015DN01185A
Authority
IN
India
Prior art keywords
relates
bis
preparation
ioforminol
preparing
Prior art date
Application number
Inventor
Mikkel Thaning
Andreas Olsson
Christian Glogard
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of IN2015DN01185A publication Critical patent/IN2015DN01185A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. More particularly, the invention relates to a work-up process for preparation of a compound mixture comprising l-fomylamino-3,5-bis(2,3-bis(formyloxy)propan-l-ylcarbamoyl)-2,4,6-trioodobenzene, a key intermediate in the process for preparing Ioforminol. Further, the invention relates to a process for preparing Ioforminol, a contrast agent useful in X-ray imaging.
IN1185DEN2015 2012-09-27 2015-02-13 IN2015DN01185A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20121102 2012-09-27
PCT/US2013/060081 WO2014052091A1 (en) 2012-09-27 2013-09-17 Preparation of an intermediate compound of ioforminol

Publications (1)

Publication Number Publication Date
IN2015DN01185A true IN2015DN01185A (en) 2015-06-26

Family

ID=49274871

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1185DEN2015 IN2015DN01185A (en) 2012-09-27 2015-02-13

Country Status (12)

Country Link
US (1) US9884808B2 (en)
EP (1) EP2900632B1 (en)
JP (1) JP6431842B2 (en)
KR (1) KR20150061635A (en)
CN (2) CN104661996A (en)
AU (1) AU2013323981B2 (en)
BR (1) BR112015004591A2 (en)
CA (1) CA2881852A1 (en)
IN (1) IN2015DN01185A (en)
MX (1) MX354604B (en)
RU (1) RU2654461C2 (en)
WO (1) WO2014052091A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015004591A2 (en) 2012-09-27 2017-07-04 Ge Healthcare As processes for preparing a mixture of a compound and preparing ioforminol, and mixing a compound in powder form

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3364536D1 (en) 1982-11-08 1986-08-21 Nyegaard & Co As X-ray contrast agents
WO1997000240A1 (en) 1995-06-16 1997-01-03 Biophysica Foundation Formyl derivatives as nonionic contrast media
GB9624612D0 (en) 1996-11-26 1997-01-15 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
NO20043305D0 (en) * 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
NO20053687D0 (en) * 2005-07-29 2005-07-29 Amersham Health As Crystallization Process.
CN103980154B (en) * 2007-07-12 2015-02-25 通用电气医疗集团股份有限公司 Contrast agents
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
RU2642436C2 (en) * 2012-09-27 2018-01-25 ДжиИ Хелткер АС Obtaining of ioforminol - radio-opaque agent
BR112015004591A2 (en) 2012-09-27 2017-07-04 Ge Healthcare As processes for preparing a mixture of a compound and preparing ioforminol, and mixing a compound in powder form

Also Published As

Publication number Publication date
AU2013323981B2 (en) 2017-09-14
US9884808B2 (en) 2018-02-06
US20150246871A1 (en) 2015-09-03
MX354604B (en) 2018-03-07
BR112015004591A2 (en) 2017-07-04
CA2881852A1 (en) 2014-04-03
WO2014052091A1 (en) 2014-04-03
KR20150061635A (en) 2015-06-04
JP6431842B2 (en) 2018-11-28
CN104661996A (en) 2015-05-27
RU2654461C2 (en) 2018-05-18
EP2900632A1 (en) 2015-08-05
AU2013323981A1 (en) 2015-03-05
MX2015003912A (en) 2015-08-05
RU2015107016A (en) 2016-11-20
JP2015532280A (en) 2015-11-09
CN110003038A (en) 2019-07-12
EP2900632B1 (en) 2019-10-30

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