CN104649938A - 硝基苯磺酰肼类gpr119激动剂、制备方法及其用途 - Google Patents
硝基苯磺酰肼类gpr119激动剂、制备方法及其用途 Download PDFInfo
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- CN104649938A CN104649938A CN201510080391.7A CN201510080391A CN104649938A CN 104649938 A CN104649938 A CN 104649938A CN 201510080391 A CN201510080391 A CN 201510080391A CN 104649938 A CN104649938 A CN 104649938A
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- 0 [O-][N+](*1C=CC(S(NNC(Nc(cc2)ccc2NC(Nc(c2c3CCCC2)ccc3Cl)=O)=O)(=O)=O)=CC=C1)=O Chemical compound [O-][N+](*1C=CC(S(NNC(Nc(cc2)ccc2NC(Nc(c2c3CCCC2)ccc3Cl)=O)=O)(=O)=O)=CC=C1)=O 0.000 description 1
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
Description
化合物 | EC50(nM) |
参比化合物D-1 | 20.9 |
化合物I-1 | 11.8 |
化合物I-2 | 13.1 |
化合物I-3 | 13.6 |
Claims (4)
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CN201510080391.7A CN104649938B (zh) | 2015-02-13 | 2015-02-13 | 硝基苯磺酰肼类gpr119激动剂、制备方法及其用途 |
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CN201510080391.7A CN104649938B (zh) | 2015-02-13 | 2015-02-13 | 硝基苯磺酰肼类gpr119激动剂、制备方法及其用途 |
Publications (2)
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CN104649938A true CN104649938A (zh) | 2015-05-27 |
CN104649938B CN104649938B (zh) | 2016-06-01 |
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08238852A (ja) * | 1995-03-06 | 1996-09-17 | Nippon Paper Ind Co Ltd | 感熱記録シート |
EP1314723A1 (en) * | 2001-11-27 | 2003-05-28 | Warner-Lambert Company | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases |
WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
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2015
- 2015-02-13 CN CN201510080391.7A patent/CN104649938B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08238852A (ja) * | 1995-03-06 | 1996-09-17 | Nippon Paper Ind Co Ltd | 感熱記録シート |
EP1314723A1 (en) * | 2001-11-27 | 2003-05-28 | Warner-Lambert Company | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases |
WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
Non-Patent Citations (3)
Title |
---|
MOHAMMAD REZA GANJALI等: ""novel erbium (III)-selective fluorimetric bulk optode"", 《SENSORS AND ACTUATORS B》 * |
李占梅等: ""果糖-1, 6-二磷酸酶AMP 变构抑制剂的研究进展"", 《药学学报》 * |
李鹏飞等: ""4-(取代嘧啶-2-基)-1-芳磺酰基氨基脲化合物的合成与表征"", 《有机化学》 * |
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Publication number | Publication date |
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CN104649938B (zh) | 2016-06-01 |
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Denomination of invention: Nitrobenzenesulfonyl hydrazide type GPR119 agonist, as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Date of cancellation: 20190604 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20190805 Address after: 233000 Yuhui District, Bengbu City, Anhui Province, No. 1750 Shengli West Road, No. 316 Pioneering Building, Huineng Small and Micro Enterprise Pioneering Center Patentee after: Bengbu Dingrong Science and Technology Information Consulting Co., Ltd. Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |