CN104647903B - A kind of printing head device based on micro-fluidic chip - Google Patents
A kind of printing head device based on micro-fluidic chip Download PDFInfo
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- CN104647903B CN104647903B CN201510069086.8A CN201510069086A CN104647903B CN 104647903 B CN104647903 B CN 104647903B CN 201510069086 A CN201510069086 A CN 201510069086A CN 104647903 B CN104647903 B CN 104647903B
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Abstract
The invention discloses a kind of printing head device based on micro-fluidic chip, including chip basal body, described chip basal body is provided with at least one material runner and at least one and controls runner, described material runner is used for carrying printed material, the flowing material that in described control runner, circulating pressure is controlled, described control runner is staggered with corresponding material runner and forms control valve at intervening portion, described control valve includes the fexible film separated at intervening portion by described control runner with corresponding material runner, described fexible film produces deformation according to the pressure in described control runner, control the conducting of described material runner and block.The present invention can be hocketed by single shower nozzle the printing of multiple material in a print procedure.
Description
Technical field
The present invention relates to a kind of printing head device based on micro-fluidic chip.
Background technology
The target of microfluidic chip technology (Microfluidics) is that the function in whole laboratory is integrated on microchip, and can repeatedly use.It is at least micron order yardstick that its device characteristic is mainly resulting structure (passage, reative cell and some other functional part) in a dimension, thus develops the analytical performance of uniqueness.It has, and liquid flowing is controlled, consume sample and reagent is few, carry high with analyzing speed tenfold hundreds of times, and the emphasis application of current job development is life science.
3D prints (3Dprinting), the i.e. one of rapid shaping technique, is a kind of based on mathematical model file, use powdery metal or plastics etc. can jointing material, carried out the technology of constructed object by the mode successively printed.By the method for the materials such as 3D method the molding biomaterial, particularly cell printed, biological 3D is just made to print.Biological 3D printing is the field of 3D printing technique research forefront, better in medical domain application prospect.
Jointly being printed upon of multiple material (such as various kinds of cell material) has important meaning during biological 3D prints.In order to solve this problem, the means adopted at present are mainly many nozzle printings machine.But, many nozzle printings apparatus structure is complicated, relatively costly；Frequently use work efficiency during shower nozzle instead relatively low；There is the site error that many shower nozzles coordinate compensates；And there is location conflicts between many shower nozzles, which has limited the lateral dimension of printout；After exchange, material interface has knob-like to tie more.
A kind of considerable novel thinking is single shower nozzle and multiple flow passages conveying material, by controlling the opening and closing of runner, changes the material used by nozzle printing.But, the runner of macro-size easily occurs liquid material to mix, and causes the mutual pollution of not same material.
Summary of the invention
Present invention is primarily targeted at for the deficiencies in the prior art, it is provided that a kind of ejecting device based on micro-fluidic chip, the printing of the multiple material that can be hocketed by single shower nozzle in a print procedure.
For achieving the above object, the present invention is by the following technical solutions:
A kind of printing head device based on micro-fluidic chip, including chip basal body, described chip basal body is provided with at least one material runner and at least one and controls runner, described material runner is used for carrying printed material, the flowing material that in described control runner, circulating pressure is controlled, described control runner is staggered with corresponding material runner and forms control valve at intervening portion, described control valve includes the fexible film separated at intervening portion by described control runner with corresponding material runner, described fexible film produces deformation according to the pressure in described control runner, control the conducting of described material runner and block.
Further:
Described printing head device includes a plurality of described material runner, wherein portion of material runner or all material runner be provided with correspondence described control valve, each material runner meets at converges runner, described in converge runner through delivery channel connection outlet.
The described material runner height at described control valve place is less than 100 microns, more than 50 microns.
The width of described material runner is 100-200 micron.
The width of described control runner is 200-300 micron.
The described width converging runner is 100-200 micron.
The width of described delivery channel is 100-200 micron.
Described fexible film is thickness is the PDMS film of 30-80 micron.
Described printed material is metal or plastics or biomaterial, and described biomaterial can be the fluent material containing support, nutritional solution or cell etc..
The described material runner cross section at described intervening portion place is tapered trapezoidal along the direction away from described control runner.
Described flowing material is density less than the gas of described printed material or liquid, and described control runner is positioned at above described material runner at described intervening portion place.
Beneficial effects of the present invention:
The printing head device based on micro-fluidic chip of the present invention, be capable of hocketing in a print procedure with single shower nozzle the printing of multiple material, by the gas/liquid pressure controlled in runner is controlled, make the deformation of fexible film to control the opening and closing of material runner, change the material that shower nozzle sprays, and the specific properties such as capillarity that liquid shows under micron order size, can prevent different liquid materials from mixing in runner preferably, it is prevented effectively from the mutual pollution of not same material, good engineering support is provided for biological file printing technology.The advantage such as the printing head device of the present invention has being quick on the draw, it is low to control cost, material contamination is little, plant bulk is less.The ejecting device of the present invention can directly be provided on existing 3D biometric print machine, it is achieved the controlled printing of many materials of single spraying head multiple flow passages, is with a wide range of applications.
Accompanying drawing explanation
Fig. 1 and Fig. 2 is the monnolithic case schematic diagram of the ejecting device that the preferred embodiments of the present invention provide, and Fig. 1 is overall appearance, and Fig. 2 is the perspective view of display internal structure.
Fig. 3 and Fig. 4 is the material runner in embodiment and the planar structure schematic diagram controlling runner respectively.
Fig. 5 is the perspective view controlling valve in embodiment.
Fig. 6 a is the material runner opening schematic cross-section in embodiment, and Fig. 6 b is that the material runner in embodiment closes shape cross section state schematic diagram；
The actual demonstration graph controlling example of Fig. 7 mono-.
Detailed description of the invention
Below in conjunction with accompanying drawing, embodiments of the present invention are elaborated.It is emphasized that the description below is merely exemplary, rather than in order to limit the scope of the present invention and application thereof.
In some embodiments, based on micro-fluidic chip ejecting device structure as shown in Figures 1 to 7.Ejecting device includes chip basal body 100 and the material runner 200 being formed in chip basal body 100, controls runner 300 and control valve 400.Wherein, controlling runner 300 and interlock with material runner 200 and be spatially positioned at above material runner 200, both staggered places are formed with control valve 400.Each runner is enclosed construction except gateway.In figure, the importation of material runner and control runner all have 5 tunnels, one_to_one corresponding.It is of course also possible to only for part, not all material runner arranges and controls runner accordingly, thus at least the material runner of this portion of material being played control action.The driving of material runner can adopt syringe pump or peristaltic pump, control runner and control valve can adopt gases at high pressure/liquid as operation material, directly do not contact with the liquid material in material passage in the course of the work, control runner and pneumatic/hydraulic can be adopted to drive to the driving controlling valve.
Preferably, the density of the pressure-air/liquid of employing is less than printed material, in staggered place, controls runner and is spatially positioned at above material runner 200.
As it is shown in figure 1, chip basal body 100 is provided with the entrance 101 of material runner 200, controls the gateway 102 of runner 300 and the outlet 103 of material runner 200.The gateway of the entrance of material runner 200 and control runner 300 is preferably disposed to the upper surface with macro-scale of chip basal body 100, and the outlet of material runner 200 may be disposed at the arbitrary surfaces of chip basal body 100.
As it is shown on figure 3, material runner 200 includes input duct 201, controls valve portion 202, converges runner 203 and delivery channel 204.
As shown in Figure 4, control runner 300 can pass into pressure-air, control runner 300 and include pressure-air input duct 301, control valve portion 302 and pressure-air delivery channel 303.
As shown in Figure 5, control valve 400 to include controlling runner 300 and the control runner section 401 of intervening portion of material runner 200, fexible film 402 and material runner part 403, be formed as valve arrangement, fexible film 402 separates two runners, and deformation can be produced according to the pneumatic/hydraulic controlling runner, thus control the conducting of material runner 200 and block.Fexible film 402 preferably employs restorative stronger thin-film material after having deformability and deforming, control runner and material runner are separated by it, bend by pressure plugging material runner when in controlling runner, gas/liquid pressure increases, it is achieved runner is closed, on the contrary open.Preferably, flexible thin-film material is PDMS (polydimethylsiloxane), and thickness should be little as far as possible, for 30-80 micron.
It is preferred that the input duct of each material runner, converge the shape of runner, be closely sized to, delivery channel can omit width, in order to reduces systematic error when controlling runner opening and closing.
The operation principle of the controlled printing of many materials is as follows.
Referring to Fig. 3, various materials are inputted by each input duct entrance respectively with certain hydraulic pressure P1, control through controlling valve, and only a kind of material of synchronization flows into and converges runner, and flows to spray outlet by delivery channel outlet.
Referring to Fig. 4, control to flow all the time in runner gas controlled for pressure P or liquid working substance, is realized the control of material runner by controlled medium pressure, and direction is as shown in the figure.
Referring to Fig. 6 a and Fig. 6 b, when certain road controls the gas in runner section 401 or liquid pressure P more than the liquid conveying pressure P1 in material runner part 403 and this pressure marginal value of pressure P2 sum needed for the complete deformation of fexible film 402 (P > P1+P2), material runner 403 can be made to block, otherwise turn on.Reality can control pressure P and be far longer than marginal value (i.e. P > > P1+P2) to realize reliably blocking of material runner 403.By controlling the pressure P of each control runner, what can control each material runner 403 goes out liquid.
In a preferred embodiment, the cross section of material runner part 403 is along away from tapered trapezoidal in direction controlling runner section 401, and this design is conducive to making fexible film 402 completely plugged material runner when material runner is closed controlling.
Such as Fig. 7, the sequential control valve of C-D-A-D as illustrated can opening (during a valve opening, other valves are turned off), the liquid stream c-d-a-d obtained at delivery channel is as shown.
Material runner is highly preferred less than 100 microns.Meeting on the basis closing down condition, the height of material runner can more than 50 microns, to avoid runner to block.
Preferably, each flow channel entry point, in the surrounding of chip basal body, converges runner and is positioned at chip basal body side, near outlet.Controlling flow channel shape and be preferably U-shaped, entrance and outlet are set up separately in material runner entrance both sides.
Preferably, converge runner width 100-200 micron, input duct and delivery channel width 100-200 micron, control runner width 200-300 micron, control valve place material runner width 100-200 micron.
Preferably, optional 50 microns of material runner height.Control valve place material runner length and all select 300 microns with width.
The material of chip basal body can be glass, and processing mode is the micro Process based on photoetching.
By adopting above-mentioned multiple flow passages on micro-fluidic chip and controlling the structural design of valve, the controlled printing of material more than single spraying can be realized preferably, and have and be quick on the draw, control the advantages such as cost is low, material contamination is little, plant bulk is less, it is easy to apply on existing cell printing machine.
Above content is to combine concrete/preferred embodiment further description made for the present invention, it is impossible to assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention; without departing from the inventive concept of the premise; these embodiments having described that can also be made some replacements or modification by it, and these substitute or variant all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. the printing head device based on micro-fluidic chip, it is characterized in that, including chip basal body, described chip basal body is provided with at least one material runner and at least one and controls runner, described material runner is used for carrying printed material, the flowing material that in described control runner, circulating pressure is controlled, described control runner is staggered with corresponding material runner and forms control valve at intervening portion, described control valve includes the fexible film separated at intervening portion by described control runner with corresponding material runner, described fexible film produces deformation according to the pressure in described control runner, control the conducting of described material runner and block.
2. printing head device as claimed in claim 1, it is characterized in that, including a plurality of described material runner, wherein portion of material runner or all material runner are provided with the described control valve of correspondence, each material runner meets at converges runner, described in converge runner through delivery channel connection outlet.
3. printing head device as claimed in claim 1 or 2, it is characterised in that the described material runner height at described control valve place is less than 100 microns, more than 50 microns.
4. printing head device as claimed in claim 1 or 2, it is characterised in that the width of described material runner is 100-200 micron.
5. printing head device as claimed in claim 1 or 2, it is characterised in that the width of described control runner is 200-300 micron.
6. printing head device as claimed in claim 2, it is characterised in that described in converge the width of runner and/or described delivery channel be 100-200 micron.
7. the printing head device as described in claim 1 or 2 or 6, it is characterised in that described printed material is metal or plastics or biomaterial, and described biomaterial is the fluent material containing support, nutritional solution or cell.
8. the printing head device as described in claim 1 or 2 or 6, it is characterised in that described fexible film is thickness is the PDMS film of 30-80 micron.
9. the printing head device as described in claim 1 or 2 or 6, it is characterised in that the described material runner cross section at described intervening portion place is tapered trapezoidal along the direction away from described control runner.
10. the printing head device as described in claim 1 or 2 or 6, it is characterised in that described flowing material is density less than the gas of described printed material or liquid, and described control runner is positioned at above described material runner at described intervening portion place.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510069086.8A CN104647903B (en) | 2015-02-09 | 2015-02-09 | A kind of printing head device based on micro-fluidic chip |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510069086.8A CN104647903B (en) | 2015-02-09 | 2015-02-09 | A kind of printing head device based on micro-fluidic chip |
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| CN104647903A CN104647903A (en) | 2015-05-27 |
| CN104647903B true CN104647903B (en) | 2016-07-06 |
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| CN201510069086.8A Expired - Fee Related CN104647903B (en) | 2015-02-09 | 2015-02-09 | A kind of printing head device based on micro-fluidic chip |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6520519B2 (en) * | 2015-07-24 | 2019-05-29 | セイコーエプソン株式会社 | Channel structure and liquid jet head |
| CN105238676B (en) * | 2015-10-15 | 2017-04-05 | 清华大学深圳研究生院 | A kind of micro-fluidic chip for cell printing |
| CN105925479B (en) * | 2016-04-25 | 2018-08-24 | 清华大学深圳研究生院 | A kind of gradient 3D printing nozzle and 3D printer |
| WO2018165761A1 (en) * | 2017-03-15 | 2018-09-20 | Aspect Biosystems Ltd. | Systems and methods for printing a fiber structure |
| DE102017122488A1 (en) | 2017-09-27 | 2019-03-28 | Dürr Systems Ag | Applicator with a sealing membrane |
| DE102017122493A1 (en) | 2017-09-27 | 2019-03-28 | Dürr Systems Ag | Applicator with small nozzle spacing |
| DE102017122495A1 (en) * | 2017-09-27 | 2019-03-28 | Dürr Systems Ag | Applicator with a small nozzle spacing |
| CN107937270B (en) * | 2017-11-17 | 2021-02-26 | 清华大学深圳研究生院 | Micro-fluidic chip nozzle and biological 3D printer |
| CN110355991A (en) * | 2018-04-09 | 2019-10-22 | 北京大学 | 3D printing method and 3D printing equipment |
| CN108953758B (en) * | 2018-10-09 | 2019-09-10 | 河海大学常州校区 | A kind of microfluidic valve and its microfluid regulate and control method |
| CN109822898B (en) * | 2019-03-18 | 2020-09-15 | 清华大学 | Micro-nozzle device for biological 3D printer and application thereof |
| CN114720653A (en) * | 2022-05-24 | 2022-07-08 | 武汉正元环境科技股份有限公司 | Water quality detection method and device based on micro-flow control chip |
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| US20080003404A1 (en) * | 2006-06-30 | 2008-01-03 | 3M Innovative Properties Company | Flexible circuit |
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Inventor after: Sun Wei Inventor after: Victory Inventor after: Xu Yuanyuan Inventor after: Guo Xiao Inventor after: Wu Xiaoyue Inventor after: Qian Xiang Inventor before: Victory Inventor before: Xu Yuanyuan Inventor before: Guo Xiao Inventor before: Sun Wei Inventor before: Wu Xiaoyue Inventor before: Qian Xiang |
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