CN109092378A - A kind of micro-fluidic chip flow light control method based on phasmon nanostructure - Google Patents
A kind of micro-fluidic chip flow light control method based on phasmon nanostructure Download PDFInfo
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Abstract
A kind of micro-fluidic chip flow light control method based on phasmon nanostructure, the present invention relates to micro-fluidic chip flow light control methods.The purpose of the present invention is to solve existing microfluidic device is complicated for operation, equipment is expensive, and portability is poor and light-operated micro-fluidic technologies need to be added other media into microfluid, or the problem of use special fluid channel material etc., strongly limit the application range of microflow control technique.Process are as follows: one, be calculated different sizes, the nanometer stick array of different interval and different materials nanometer stick array absorption cross-section under different incident laser intensities and polarization direction, the temperature field of fluid and Flow Field Distribution situation in fluid channel where nanometer stick array；Two, satisfactory nano-array is chosen；Three, the satisfactory nanometer stick array chosen using the laser irradiation of wavelengths characteristic regulates and controls the microfluidic of fluid in fluid channel by the laser intensity of control characteristic wavelength and polarization direction.The present invention is used for micro-fluidic field.
Description
Technical field
The present invention relates to the micro-fluidic chip flow light control methods based on phasmon nanostructure.
Background technique
Microflow control technique can be applied to biomedicine, medicine and pharmacology, the various fields such as chemistry and biology.Specifically its
All in occupation of importantly in the application of MEMS, biochip, chip lab, micro-total analysis system and Micro-Robot
Position.The research of microflow control technique at present is concentrated mainly on two aspects of micro-valve and Micropump, and the driving method of micro-valve mainly includes shape
The driving of shape memory material, piezoelectric effect driving, electrostatic force and electromagnetism power drive, capillary power drive etc..Micropump is broadly divided into machine
Tool formula and non-mechanical Micropump.
Compared to other measuring technologies, micro-fluidic remarkable advantage is that consumption amount of reagent is minimum, can greatly reduce
Operating cost.Meanwhile lesser amount of reagent (nanoliter to picoliters) can improve analysis efficiency, save the testing time, be more suitable for facing
The timely detection of bed medicine.Simultaneously as microfluidic device small volume (except external device), it can be by a variety of different function collection
On Cheng Yi fritter chip, forms complete microfluidic system and be easy to use.Due to its superior performance and development prospect, miniflow
Control technology was cited as influencing human future most important invention in 15 years in 2003, and changed following one of the technology.
However, traditional microflow control technique is primarily present following problems: being used to control firstly the need of complicated external device
The flowing of microfluid causes microfluidic device complicated for operation, and equipment is expensive, and portability is poor.It is proposed in recent years light-operated micro-
Although fluid technique solves the above problem to a certain extent, other problems are brought simultaneously, are such as needed into microfluid
Other media are added, or use special fluid channel material etc..This strongly limits the application ranges of microflow control technique, such as in life
In object medicine detection process, other additives meeting pollution detection sample is added into fluid, to influence testing result.
Summary of the invention
The purpose of the present invention is to solve existing microfluidic device is complicated for operation, equipment is expensive, and portability it is poor with
And light-operated micro-fluidic technologies need to be added other media into microfluid, or use special fluid channel material etc., greatly limit
The problem of application range of microflow control technique, and propose a kind of micro-fluidic chip flow light based on phasmon nanostructure
Control method.
A kind of micro-fluidic chip flow light control method detailed process based on phasmon nanostructure are as follows:
Step 1: different sizes are calculated, the nanometer stick array of different interval and different materials is different incident sharp
Nanometer stick array absorption cross-section under luminous intensity and polarization direction, the temperature field and flow field of fluid in fluid channel where nanometer stick array
Distribution situation；
Step 2: choosing satisfactory nano-array according to the calculated result of step 1；Detailed process are as follows:
(1) it is chosen under different incident laser intensities and polarization direction, the difference of the same nanometer stick array absorption cross-section
Change maximum nanometer stick array；
(2) it on satisfaction (1) conditioned basic, chooses under identical incident laser intensity and polarization direction, nanometer stick array institute
The temperature of fluid increases highest nanometer stick array in fluid channel；
If it is 1 that temperature, which increases highest nanometer stick array, it is to meet the requirements that temperature, which increases highest nanometer stick array,
Nano-array；
If temperature, which increases highest nanometer stick array, is greater than 1, (3) are executed；
(3) on satisfaction (2) conditioned basic, the maximum nanometer rods of fluid channel inner fluid speed where nanometer stick array are chosen
Array is as satisfactory nano-array；
Step 3: the satisfactory nanometer stick array chosen using the laser irradiation step two of wavelengths characteristic, passes through tune
Save the microfluidic of fluid in the laser intensity and polarization direction regulation fluid channel of wavelengths characteristic.
The invention has the benefit that
The present invention passes through theoretical calculation first and obtains different sizes, and the nanometer stick array of different interval and different materials exists
Nanometer stick array absorption cross-section under different incident laser intensities and polarization direction, the temperature of fluid in fluid channel where nanometer stick array
Field and Flow Field Distribution situation are spent, the light-operated miniature valve in different types fluid channel is then designed on this basis, finally by tune
The method for saving the intensity and polarization direction of incident laser, reaches the control accurate to fluid in fluid channel.The present invention uses stable state
Laser, laser buy cheap is convenient, easy to operate, and without other external equipments in addition to polarizing film, the scope of application is wider, greatly
It is complicated for operation to improve traditional microflow control technique external equipment, equipment is expensive, and portability poor.The present invention can apply
In the fluid channel of different types, a kind of quick, easy method is provided for accurately microflow control technique, to biomedicine, doctor
Pharmacy, chemistry and biology all have a very important significance.
It is less than the Y type micro sprue system of 1000nm/s for inlet flow rate, the flow adjustment range arbitrarily exported is total
The 35%~65% of inlet flow rate.
Detailed description of the invention
Fig. 1 is light-operated microfluidic valve schematic device in Y type fluid channel in the specific embodiment of the invention one, θ be runner A and
Angle between runner B takes 90 °；A is runner A, and B is runner B；
Fig. 2 is light-operated microfluidic valve operation principle schematic diagram in Y type fluid channel in the specific embodiment of the invention one, and k is sharp
The incident direction of light, EincFor the electric field strength of incident laser；
Fig. 3 is the light-operated microfluidic valve absorption factor of the present invention and direction character parameter schematic diagram, E are electric field strength；
Fig. 4 is light-operated miniflow valve gear and operation principle schematic diagram in Y type fluid channel in the specific embodiment of the invention one,
H0Indicate different fluid channel height, K is the unit of temperature；
Fig. 5 is light-operated miniflow valve gear and operation principle schematic diagram in Y type fluid channel in the specific embodiment of the invention one,
Inlet is entrance.
Specific embodiment
Specific embodiment 1: a kind of micro-fluidic chip flow light based on phasmon nanostructure of present embodiment
Control method detailed process are as follows:
Step 1: different sizes are calculated, the nanometer rods of different interval (being spaced between nanometer rods) and different materials
Array (multiple nanometer rods composition nanometer stick arrays) nanometer stick array under different incident laser intensities and polarization direction, which absorbs, to be cut
Face, the temperature field of fluid and Flow Field Distribution situation in fluid channel where nanometer stick array；
Difference is having a size of A1, different interval A2, different materials A3, different incident laser intensities are B1, different polarization side
To for B2；
A1, A2, A3, B1, B2Separately include many situations；
Nanometer stick array (multiple nanometer rods of different sizes, different interval (being spaced between nanometer rods) and different materials
Form nanometer stick array) it is divided into following situations in different incident laser intensities and polarization direction:
A1B1, A1B2, A2B1, A2B2, A3B1, A3B2；
A1A2B1, A1A2B2, A2A3B1, A2A3B2, A1A3B1, A1A3B2；
A1A2A3B1, A1A2A3B2；
A1B1B2, A2B1B2, A3B1B2；
A1A2B1B2, A1A3B1B2, A2A3B1B2；
A1A2A3B1B2；
Step 2: choosing satisfactory nano-array according to the calculated result of step 1；Detailed process are as follows:
(1) it is chosen under different incident laser intensities and polarization direction, the difference of the same nanometer stick array absorption cross-section
Change maximum nanometer stick array；
What the Comsol Multiphysics software used by embodiment two was calculated.
(2) it on satisfaction (1) conditioned basic, chooses under identical incident laser intensity and polarization direction, nanometer stick array institute
The temperature of fluid increases highest nanometer stick array in fluid channel；
If it is 1 that temperature, which increases highest nanometer stick array, it is to meet the requirements that temperature, which increases highest nanometer stick array,
Nano-array；
If temperature, which increases highest nanometer stick array, is greater than 1, (3) are executed；
What the Comsol Multiphysics software used by embodiment two was calculated.
(3) on satisfaction (2) conditioned basic, the maximum nanometer rods of fluid channel inner fluid speed where nanometer stick array are chosen
Array is as satisfactory nano-array；
What the Comsol Multiphysics software used by embodiment two was calculated；
Step 3: being conformed under fluid channel normal running conditions using what the laser irradiation step two of wavelengths characteristic was chosen
The nanometer stick array asked regulates and controls the microfluidic of fluid in fluid channel by the laser intensity of control characteristic wavelength and polarization direction.
Specific embodiment 2: the present embodiment is different from the first embodiment in that: it is calculated in the step 1
To different sizes, the nanometer stick array of different interval and different materials nanometer under different incident laser intensities and polarization direction
Stick array absorption cross-section, the temperature field of fluid and Flow Field Distribution situation in fluid channel where nanometer stick array；Detailed process are as follows:
Different sizes, different interval and different materials are calculated using business software Comsol Multiphysics
Nanometer stick array under different incident laser intensities and polarization direction nanometer stick array absorption cross-section, it is micro- where nanometer stick array
The temperature field of fluid and Flow Field Distribution situation in runner.
Other steps and parameter are same as the specific embodiment one.
Specific embodiment 3: the present embodiment is different from the first and the second embodiment in that: make in the step 3
With the specific choice standard of the laser of wavelengths characteristic are as follows:
(1) the maximum wavelength of selected directions characteristic parameter, wherein direction character parameter definition are as follows:
Wherein Q||And Q⊥Respectively indicate absorption factor when incident laser polarization direction is parallel and perpendicular to nanometer stick array；
(2) absorption factor maximum wavelength is chosen on the basis of the condition that meets (1).
Other steps and parameter are the same as one or two specific embodiments.
Specific embodiment 4: unlike one of present embodiment and specific embodiment one to three: described to use quotient
Different sizes are calculated with software Comsol Multiphysics, and the nanometer stick array of different interval and different materials exists
Nanometer stick array absorption cross-section under different incident laser intensities and polarization direction, the temperature of fluid in fluid channel where nanometer stick array
Spend field and Flow Field Distribution situation；Detailed process are as follows:
The absorption cross-section of nanometer stick array is calculate by the following formula to obtain:
Wherein CabsFor absorption cross-section size；I0For incident laser intensity；Q is the power loss density in nanometer stick array；
V is nanometer stick array volume；
One-wavelength laser irradiates the Temperature Distribution of fluid in lower nanometer stick array and nanometer stick array place fluid channel by asking
Solution Transient Heat Transfer equation obtains:
Wherein subscript Au and w respectively indicate Jin Heshui；ρ, c and k respectively indicate density, specific heat capacity and thermal coefficient；T table
Temperature displaying function (fluid temperature (F.T.) in fluid channel where referring to nanometer stick array temperature or nanometer stick array)；R and t respectively indicates position (position
Set and refer to fluid in nanometer stick array or nanometer stick array place fluid channel) and the time；The flowing velocity of u expression water；ρAuIndicate gold
Density, cAuIndicate the specific heat capacity of gold, kAuIndicate the thermal coefficient of gold, ρwIndicate the density of water, cwIndicate the specific heat capacity of water, kw
Indicate the thermal coefficient of water,For Hamiltonian；Q (r) indicates that heat source, heat source q (r) are solved by following formula:
Wherein ω indicates the frequency of incident laser；ε indicates the dielectric constant of material at the r of position；E indicates electric field strength；
The Flow Field Distribution of fluid is obtained by solving Navier Stokes equation in fluid channel where nanometer stick array:
Wherein v indicates the dynamic viscosity of water；The flowing velocity of u expression water；fthIndicate the temperature difference due to the different location of water
Caused buoyancy is calculate by the following formula to obtain:
fth(T)=β g δ T (r, t) uz (6)
Wherein g indicates acceleration of gravity；The coefficient of expansion of β expression water；uzIndicate the unit vector of gravity opposite direction；δ T table
Temperature indicating is poor.
Other steps and parameter are identical as one of specific embodiment one to three.
Beneficial effects of the present invention are verified using following embodiment: being less than the Y type miniflow of 1000nm/s for inlet flow rate
Road system, the flow adjustment range arbitrarily exported are the 35%~65% of total inlet flow.
Embodiment one:
The present embodiment is specifically to be prepared according to the following steps:
One, the Y type fluid channel for being 8 μm for width, choosing length is 0.5 μm, and it is highly 0.1 μm that width, which is 0.2 μm,
For nanometer rods as light-operated microfluidic valve, absorption factor and direction character parameter are as shown in Figure 3.According to specific embodiment four, choosing
Taking wavelength is the light source of 800nm.
Two, light-operated microfluidic valve size and optical source wavelength according to selected by one, have been calculated different fluid channel height items
The flow of two outlets is relative to inlet flow rate proportion under part, as shown in Figure 4.
H in figure0Indicate that different fluid channel height, temperature are the temperature of light-operated microfluidic valve.It can be seen that the flow of outlet
Control range is the 35%~65% of total inlet flow.When inlet flow rate is 50nm/s, temperature field and Flow Field Distribution in fluid channel
As shown in Figure 5.
The present invention can also have other various embodiments, without deviating from the spirit and substance of the present invention, this field
Technical staff makes various corresponding changes and modifications in accordance with the present invention, but these corresponding changes and modifications all should belong to
The protection scope of the appended claims of the present invention.
Claims (4)
1. a kind of micro-fluidic chip flow light control method based on phasmon nanostructure, it is characterised in that: the method
Detailed process are as follows:
Step 1: different sizes are calculated, the nanometer stick array of different interval and different materials is strong in different incident lasers
Nanometer stick array absorption cross-section under degree and polarization direction, the temperature field of fluid and Flow Field Distribution in fluid channel where nanometer stick array
Situation；
Step 2: choosing satisfactory nano-array according to the calculated result of step 1；Detailed process are as follows:
(1) it is chosen under different incident laser intensities and polarization direction, the difference variation of the same nanometer stick array absorption cross-section
Maximum nanometer stick array；
(2) it on satisfaction (1) conditioned basic, chooses under identical incident laser intensity and polarization direction, it is micro- where nanometer stick array
The temperature of fluid increases highest nanometer stick array in runner；
If it is 1 that temperature, which increases highest nanometer stick array, it is satisfactory receive that temperature, which increases highest nanometer stick array,
Rice array；
If temperature, which increases highest nanometer stick array, is greater than 1, (3) are executed；
(3) on satisfaction (2) conditioned basic, the maximum nanometer stick array of fluid channel inner fluid speed where nanometer stick array is chosen
As satisfactory nano-array；
Step 3: the satisfactory nanometer stick array chosen using the laser irradiation step two of wavelengths characteristic, special by adjusting
Property wavelength laser intensity and polarization direction regulation fluid channel in fluid microfluidic.
2. a kind of micro-fluidic chip flow light control method based on phasmon nanostructure according to claim 1,
It is characterized in that: being calculated different sizes in the step 1, the nanometer stick array of different interval and different materials is in difference
Nanometer stick array absorption cross-section under incident laser intensity and polarization direction, the temperature field of fluid in fluid channel where nanometer stick array
With Flow Field Distribution situation；Detailed process are as follows:
Different sizes are calculated using business software Comsol Multiphysics, different interval and different materials are received
Rice stick array nanometer stick array absorption cross-section under different incident laser intensities and polarization direction, fluid channel where nanometer stick array
The temperature field of interior fluid and Flow Field Distribution situation.
3. a kind of micro-fluidic chip flow light control method based on phasmon nanostructure according to claim 2,
It is characterized in that: using the specific choice standard of the laser of wavelengths characteristic in the step 3 are as follows:
(1) the maximum wavelength of selected directions characteristic parameter, wherein direction character parameter definition are as follows:
WhereinWithRespectively indicate absorption factor when incident laser polarization direction is parallel and perpendicular to nanometer stick array；
(2) absorption factor maximum wavelength is chosen on the basis of the condition that meets (1).
4. a kind of micro-fluidic chip flow light control method based on phasmon nanostructure according to claim 3,
It is characterized in that: described that different sizes, different interval and difference are calculated using business software Comsol Multiphysics
The nanometer stick array of material nanometer stick array absorption cross-section under different incident laser intensities and polarization direction, nanometer stick array institute
The temperature field of fluid and Flow Field Distribution situation in fluid channel；Detailed process are as follows:
The absorption cross-section of nanometer stick array is calculate by the following formula to obtain:
Wherein CabsFor absorption cross-section size；I0For incident laser intensity；Q is the power loss density in nanometer stick array；V is to receive
Rice stick array volume；
The Temperature Distribution of fluid passes through solution wink in fluid channel where one-wavelength laser irradiates lower nanometer stick array and nanometer stick array
State heat transfer equation obtains:
Wherein subscript Au and w respectively indicate Jin Heshui；ρ, c and k respectively indicate density, specific heat capacity and thermal coefficient；T indicates temperature
Degree；R and t respectively indicate position and time；The flowing velocity of u expression water；ρAuIndicate the density of gold, cAuIndicate the specific heat capacity of gold,
kAuIndicate the thermal coefficient of gold, ρwIndicate the density of water, cwIndicate the specific heat capacity of water, kwIndicate the thermal coefficient of water, ▽ is Hami
Pause operator；Q (r) indicates heat source；
Heat source q (r) is solved by following formula:
Wherein ω indicates the frequency of incident laser；ε indicates the dielectric constant of material at the r of position；E indicates electric field strength；
The Flow Field Distribution of fluid is obtained by solving Navier Stokes equation in fluid channel where nanometer stick array:
Wherein v indicates the dynamic viscosity of water；The flowing velocity of u expression water；fthIt indicates to cause due to the temperature difference of the different location of water
Buoyancy, be calculate by the following formula to obtain:
fth(T)=β g δ T (r, t) uz (6)
Wherein g indicates acceleration of gravity；The coefficient of expansion of β expression water；uzIndicate the unit vector of gravity opposite direction；δ T indicates temperature
Difference.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112326602A (en) * | 2020-10-15 | 2021-02-05 | 哈尔滨工业大学 | Screening method and application of nanocomposite capable of realizing dual functions of tumor optical diagnosis and photothermal therapy |
| CN113058668A (en) * | 2021-03-20 | 2021-07-02 | 山东大学 | Artificial surface plasmon micro-fluidic detection chip structure based on capacitive metamaterial structure and preparation and detection methods thereof |
| CN114295550A (en) * | 2021-12-31 | 2022-04-08 | 电子科技大学长三角研究院(湖州) | Optical flow control device based on surface lattice resonance and application thereof |
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| WO2017035262A1 (en) * | 2015-08-24 | 2017-03-02 | Gpb Scientific, Llc | Methods and devices for multi-step cell purification and concentration |
| CN105319197A (en) * | 2015-12-02 | 2016-02-10 | 中国科学院苏州生物医学工程技术研究所 | Liquid drop micro-fluidic chip based on microlens array |
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| CN112326602A (en) * | 2020-10-15 | 2021-02-05 | 哈尔滨工业大学 | Screening method and application of nanocomposite capable of realizing dual functions of tumor optical diagnosis and photothermal therapy |
| CN113058668A (en) * | 2021-03-20 | 2021-07-02 | 山东大学 | Artificial surface plasmon micro-fluidic detection chip structure based on capacitive metamaterial structure and preparation and detection methods thereof |
| CN114295550A (en) * | 2021-12-31 | 2022-04-08 | 电子科技大学长三角研究院(湖州) | Optical flow control device based on surface lattice resonance and application thereof |
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