CN114295550A - Optical flow control device based on surface lattice resonance and application thereof - Google Patents
Optical flow control device based on surface lattice resonance and application thereof Download PDFInfo
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Abstract
The invention discloses a surface lattice resonance-based optical flow control device and application thereof, belonging to the technical field of optical flow control and comprising a substrate layer, a thin film layer, a periodic nano-structure layer and a liquid environment layer. The light absorption rate is obviously improved through the interference phenomenon caused by the local surface plasmon resonance generated by the periodic nano-structure layer and the diffraction grating action supported by the periodic arrangement of the nano-structure on the metal film layer. In addition, the film layer can effectively diffuse heat generated by the nano structures arranged on the film layer, the spatial range of temperature distribution is increased through self heat dissipation, and the photo-thermal response of the device is remarkably improved, so that the flow rate of fluid convection induced by the photo-thermal response is improved, and the problem of low photo-flow control rate of the traditional plasmon photo-flow control device is solved. The invention can be used for medical care diagnosis and prevention and detection of certain diseases.
Description
Technical Field
The invention belongs to the technical field of optical flow control, and particularly relates to an optical flow control device based on surface lattice resonance and application thereof.
Background
Optofluidic control mainly studies how to control the interaction of light and fluid on a micro-nano scale. With the rapid development of optofluidic technologies in recent years, the trend of miniaturization, price reduction and compactness of flow cytometers is becoming more and more obvious, which will bring great convenience to medical care diagnosis and preventive detection of certain diseases. In recent years, in the field of optofluidic research, plasmons are attracting more and more attention due to their unique properties such as excellent near-field local enhancement, breakthrough of optical diffraction limit characteristics, confinement of a light field in a sub-wavelength scale, and remarkable photothermal response. By utilizing the temperature gradient characteristic generated by the photo-thermal effect enhanced by the plasmon, the heat energy can be further converted into energy in other forms such as force, sound and the like, and the method is applied to the field of optical flow control. Currently, the most mature application is the use of energy conversion, such as photo-thermal-force, as a mechanism for the transport and capture of molecules or drugs for biomedical devices, disease diagnosis or detection. For example, thermally induced convection sustained by the electromagnetic heat generated by localized plasmonic structures can be used for microfluidic mixing (Applied Physics Letters,2008,92(12): 124108). The photothermal effect of the localized plasmon structure induced by the gold nanorods is converted into a strong optical gradient force, and the strong optical gradient force can be Applied to particle aggregation (Applied Physics Letters,2012,101(5): 053118). It can be seen that convection induced by the photothermal effect of the plasmonic structure has very important application value for particle transmission and capture on the micro-nano scale. The Chinese patent CN109092378B discloses a micro-fluidic chip flow rate light control method based on a plasmon nano structure, which adopts nano rods made of different materials to realize different temperature and flow field distributions, and realizes the accurate regulation and control of fluid in a micro-channel by regulating the polarization and the intensity of external pump light.
Although plasmonic micro-nano structures can be used as micro-nano heat sources, common plasmonic structures (such as particles, super-surface structures) have low light absorption rate, and thus the flow velocity of induced fluid convection is low. Moreover, the structures are single structural unit responses under the action of external light, and finally the whole structure shows a macroscopic photo-thermal-fluidic physical process instead of all structural unit resonance responses. This results in low flow rates for its photothermal response and thus induced fluid convection, preventing its application as a photothermal fluidic device.
Disclosure of Invention
The invention aims to solve the technical problems that the traditional optofluidic device based on a plasmon structure is low in light absorption rate and low in fluid convection speed induced by the low light absorption rate, and provides an optofluidic device based on surface lattice resonance. The light absorption rate is obviously improved through the interference phenomenon caused by the local surface plasmon resonance generated on the periodic nano-structure layer and the diffraction grating behavior supported by the periodic arrangement of the nano-structure on the film; the structure can realize resonance response of all structural units. The film layer in the structure not only can effectively diffuse the heat generated by the nano structures arranged on the film layer, but also can increase the spatial range of temperature distribution through self heat dissipation, obviously improve the photo-thermal response of the device, and further improve the flow rate of the fluid convection of the liquid environment layer induced by the photo-thermal response.
The technical problem to be solved by the invention is realized by the following technical scheme:
the utility model provides a optofluidic device based on surface lattice resonance, includes substrate layer 10, thin layer 20, periodic nanostructure layer 30, thin layer 20 sets up on the substrate layer, periodic nanostructure layer 30 sets up on the thin layer, periodic nanostructure layer 30 comprises the micro-nano structure of periodic arrangement, its characterized in that: the surface lattice resonance-based optofluidic device further comprises a liquid environmental layer 40, the liquid environmental layer 40 being disposed on the periodic nanostructure layer 30 for converting heat generated by the device into convection.
It is further preferred that the thin film layer be a high thermal conductivity material for effectively diffusing the heat generated by the periodic nanostructure layer 30 arranged thereon, while the heat dissipation of the thin film layer 20 itself can increase the spatial range of temperature distribution, improving the photothermal response, and thus increasing the flow rate of the fluid convection induced thereby.
More preferably, the thin film layer is a gold thin film or graphite.
Further preferably, the micro-nano structure in the periodic nano structure layer is circular or square.
Further preferably, the periodic nanostructure layer 30 is composed of a plurality of nanopillars with a radius of 70-170nm and a thickness of 20-80nm, the nanopillars are spatially arranged according to a periodic square structure or hexagonal structure, and the gap between adjacent nanopillars is 550-620 nm.
Further preferably, the periodic nanostructure layer 30 is composed of a plurality of square nanoplates with the side length of 140-340nm and the thickness of 20-80nm, the plurality of square nanoplates are spatially arranged according to a periodic square structure or hexagonal structure, and the gap between adjacent square nanoplates is 550-620 nm.
Further preferably, the thickness of the thin film layer is 20-100 nm, preferably 40 nm.
More preferably, the material of the substrate layer is a dielectric material, preferably silicon dioxide.
In a second aspect, the present invention provides an application of a surface lattice resonance-based optofluidic device in disease diagnosis and treatment, wherein the application of the surface lattice resonance-based optofluidic device includes the following steps:
step 3, mixing the antibody-modified large-size nano structure into a micro-flow chamber;
step 5, the fluorescence-labeled nanostructure modified by the antigen and the nanostructure modified by the antibody collide under the action of convection and fully perform antigen-antibody reaction, at the moment, the nanostructure with the specific antigen is attached to the nanostructure modified by the antibody to form an aggregation structure, and moves along a streamline under the action of convection, so that the aggregation structure is aggregated near the light flow control device;
and 6, closing the laser, carrying out fluorescence detection on the gathering structure gathered near the optical flow control device, and judging whether the antigen and the antibody react according to whether the antigen is detected so as to finish the detection of the antibody.
Compared with the prior art, the invention has the following beneficial effects:
the optofluidic device of the present invention is a surface lattice resonance-based structure that achieves a collective response of resonant structures through coupling of localized surface plasmon resonances occurring on the nanostructures with rayleigh anomalous diffracted light supported by periodic arrangement of the nanostructures on a high thermal conductivity film, whereas ordinary localized plasmon resonance optofluidic devices are only single device responses. When incident light irradiates the optofluidic device of the present invention, surface lattice resonance occurs due to interference phenomena caused by localized surface plasmon resonance occurring in the periodic nanostructure layer constituting the optofluidic device and diffraction grating behavior supported by the periodic arrangement of the nanostructures on the thin film layer, which can generate a stronger localized electromagnetic field and higher absorption than an optofluidic device based on localized plasmon resonance in which only dipole electromagnetic resonance occurs. Therefore, the device can effectively convert more energy of incident light into kinetic energy of collective vibration of electrons, and finally convert the energy into more heat energy through electron-phonon interaction. This thermal energy is dissipated from the periodic nanostructure layers and the thin film layers to the liquid environmental layer by thermal radiation and conduction processes, which can create higher temperature gradients in the liquid environmental layer. Fluid convection may eventually occur due to changes in the density of the liquid caused by changes in its temperature. Because the magnitude of the fluid flow velocity in fluid convection is dependent on temperature changes, the surface lattice resonance-based optofluidic device of the present invention can produce faster fluid convection. Meanwhile, the thin film layer of the optofluidic device can not only effectively diffuse the heat generated by the nano structures arranged on the thin film layer, but also increase the spatial range of temperature distribution through self heat dissipation, so that the optofluidic device based on surface lattice resonance allows the temperature field to be reconstructed widely in space and time, and provides higher control freedom for optofluidic applications such as particle manipulation and the like.
Drawings
Fig. 1 is a schematic structural diagram of a surface lattice resonance-based optofluidic device according to example 1 of the present application;
FIG. 2 is a schematic structural diagram of a local plasmon resonance-based optofluidic device;
fig. 3 is a graph comparing an absorption spectrum and an electromagnetic field distribution of a surface lattice resonance-based optofluidic device and a localized plasmon resonance-based optofluidic device in example 1 of the present application, where (a) is the absorption spectrum of the surface lattice resonance-based optofluidic device, (b) is the absorption spectrum of the localized plasmon resonance-based optofluidic device, (c) is the electromagnetic field distribution of the surface lattice resonance-based optofluidic device, and (d) is the electromagnetic field distribution of the localized plasmon resonance-based optofluidic device;
fig. 4 is light-induced temperature distributions of a surface lattice resonance-based optofluidic device and a local plasmon resonance-based optofluidic device according to embodiment 1 of the present application, where (a) is the light-induced temperature distribution of the surface lattice resonance-based optofluidic device in the xz plane, (b) is the light-induced temperature distribution of the local plasmon resonance-based optofluidic device in the xz plane, (c) is the light-induced temperature distribution of the surface lattice resonance-based optofluidic device in different xy planes z 40, 0, -100 nm, and (d) is the light-induced temperature distribution of the local plasmon resonance-based optofluidic device in different xy planes z 40, 0, -100 nm;
fig. 5 is a time-space axial temperature distribution of a surface lattice resonance-based optofluidic device and a local plasmon resonance-based optofluidic device according to example 1 of the present application, where (a) is the time-space axial temperature distribution of the surface lattice resonance-based optofluidic device, and (b) is the time-space axial temperature distribution of the local plasmon resonance-based optofluidic device;
fig. 6 is a thermal induced fluid convection distribution of a surface lattice resonance-based optofluidic device and a localized plasmon resonance-based optofluidic device according to example 1 of the present application, where (a) is the thermal induced fluid convection distribution of the surface lattice resonance-based optofluidic device, (b) is the thermal induced fluid convection distribution of the localized plasmon resonance-based optofluidic device, (c) is a graph of temperature changes of the two devices with time, and (d) is a graph of flow velocity changes of the two devices with time;
fig. 7 is a schematic diagram of a surface lattice resonance-based optofluidic device according to example 2 of the present application;
fig. 8 is an absorption spectrum and an electromagnetic field distribution of a surface lattice resonance-based optofluidic device according to example 2 of the present application, where (a) is the absorption spectrum and (b) is the electromagnetic field distribution;
fig. 9 is a light-induced temperature distribution of the surface lattice resonance-based optofluidic device according to example 2 of the present application, where (a) is the light-induced temperature distribution of the surface lattice resonance-based optofluidic device in the xz plane, and (b) is the light-induced temperature distribution of the surface lattice resonance-based optofluidic device in the different xy planes z 40, 0, -100 nm;
fig. 10 is a thermal induced fluid convection distribution of the surface lattice resonance-based optofluidic device of example 2 of the present application, wherein (a) is a thermal induced fluid convection distribution in an xz plane, and (b) is a thermal induced fluid convection distribution in an xy plane;
icon: 10-a substrate layer; 20-a thin film layer; 30-a periodic nanostructure layer; 40-liquid environmental layer.
Detailed Description
In order to make those skilled in the art better understand the technical solution of the present invention, the following detailed description of the present invention is provided with specific examples, but the embodiments of the present invention are not limited thereto.
Example 1
Fig. 1 is a schematic structural diagram of a surface lattice resonance-based optofluidic device provided by the invention, and the structure includes a substrate layer, a thin film layer, a periodic nanostructure layer, and a liquid environment layer. Wherein the thin film layer is arranged on the substrate layer, and the unit structure of the periodic nano structure is a disc and is arranged on the thin film layer. A liquid environmental layer is located over the periodic nanostructure layer.
Specifically, the method comprises the following steps:
the electromagnetic, photothermal and fluid responses of the optofluidic device of this embodiment based on surface lattice resonance are as follows:
multidisciplinary problems including optics, thermodynamics and hydrodynamics were studied by computational simulation and experiments using three-dimensional finite element method FEM computation software COMSOL Multiphysics, with the specific parameters preferably as follows:
the radius of the periodical nanometer disk is 120nm, the thickness is 40nm, the period is a square period, and the period size is 590 nm. The thickness of the thin film layer was set to 100 nm.
In order to highlight the advantages of the surface lattice resonance-based optofluidic device of the present invention, the optofluidic device based on localized plasmon resonance is simultaneously designed as a contrast group in this embodiment, and a schematic structural diagram of the local plasmon resonance-based optofluidic device is shown in fig. 2, where the device includes a substrate layer, a periodic nanostructure layer (unit structure is a disk), and a liquid environment layer, where the periodic nanostructure disk is disposed on the substrate layer. The periodic nano-disc is made of a noble metal material Au. The specific parameters are the same as for optofluidic devices based on surface lattice resonances, namely: the radius of the periodical nanometer disk is 120nm, the thickness is 40nm, the period is a square period, and the period size is 590 nm.
Fig. 3 is an absorption spectrum and an electromagnetic field distribution diagram of the optical flow control device based on surface lattice resonance and the optical flow control device based on localized plasmon resonance in the present embodiment, wherein the incident light is an electromagnetic wave polarized along the x direction. From fig. 3(a), it is apparent that: the surface lattice resonance based optofluidic device has an extremely narrow absorption peak near 808nm, and the absorptivity of the optofluidic device can reach 97%. The resonance wavelength is close to the Rayleigh abnormal wavelength lambdaRAPn, where P is the structure period and n is the refractive index of the liquid environment layer. In addition, the electromagnetic field in fig. 3(c) is concentrated on both sides of the nanoplate and the thin film along the x-direction, and the strong electromagnetic field is localized on the liquid environment side of the metal/liquid environment interface, which shows that the simultaneous excitation of the localized surface plasmon resonance on the nanoplate and the rayleigh anomaly determined by the periodic arrangement, i.e. the localized surface plasmon resonance generated by the periodic nanostructure layer constituting the optofluidic device and the simultaneous excitation of the nanostructure on the metalThe diffraction grating behavior supported by the periodic arrangement on the thin film layer causes interference phenomena, that is to say surface lattice resonances are excited. As can be seen from fig. 3(b), the optical flow control device based on localized plasmon resonance has a wider absorption band near 980nm, with an absorption rate of 21.5%, corresponding to the dipole electromagnetic resonance obviously distributed on the nano-disc in fig. 3 (d). Therefore, the optical flow control device based on surface lattice resonance has significantly higher optical absorptivity than the optical flow control device based on localized plasmon resonance. In addition, due to the mirror charge in the Au thin film, it generates a radiation field equivalent to twice as high as that of the resonant nanostructure, resulting in an enhancement of the electromagnetic field of the optofluidic device based on the surface lattice resonance by nearly 2 times higher than that of the optofluidic device based on the localized plasmon resonance.
The surface lattice resonance-based optical flow control device can effectively convert the energy of incident light into kinetic energy of electron collective vibration through photothermal response, and finally converts the energy into heat energy through electron-phonon interaction. To further illustrate the advantages of the photothermal response of the surface lattice resonance-based optofluidic device of the present invention, the present embodiment discloses the light-induced temperature distributions of the surface lattice resonance-based optofluidic device and the local plasmon resonance-based optofluidic device, as shown in fig. 4. It can be observed that the spatial temperature rise of the optofluidic device based on surface lattice resonance is significantly higher in both the x-z plane (fig. 4(a)) and the x-y plane (fig. 4(c)) than in the optofluidic devices based on localized plasmon resonance (fig. 4(b) and fig. 4(d), respectively). This is because, on the one hand, the thermal conductivity of the Au thin-film layer is higher than that of SiO2A substrate which causes heat generated by the surface lattice resonance-based optofluidic device to be rapidly diffused through the Au thin-film layer; another reason is that the Au thin film layer itself, as part of the optofluidic device based on surface lattice resonance, also generates heat due to ohmic dissipation, thereby increasing the temperature and heat flow between the nano-discs.
In order to intuitively study the changes in the temperature rise distributions of the two devices in time and space, fig. 5(a) and 5(b) respectively plot axial (z-direction and x-direction) line graphs of the optofluidic device based on surface lattice resonance and the optofluidic device based on localized plasmon resonance at different irradiation times. Since the thermal conductivity of a metal is much greater than that of the surrounding liquid environment, the heat flows much faster inside the metal than in the liquid environment, and it can be observed that the maximum temperature rise at the metal surface is almost uniform in all cases. In addition, the x-direction line graph verifies the important function of the Au thin film layer on the surface lattice resonance-based light flow control device, namely the Au thin film layer not only can effectively disperse the heat generated by the nanometer disk, but also can increase the spatial temperature distribution through self heat dissipation. It has thus been demonstrated that the optofluidic device based on surface lattice resonances proposed in the present application allows a wide spatial and temporal reconstruction of the temperature field, which provides a higher degree of freedom of control for optofluidic applications such as the manipulation of particles in solution.
This thermal energy is dissipated from the periodic nanostructure layers and the thin film layers to the liquid environmental layer by thermal radiation and conduction processes, which can create a temperature gradient in the liquid environmental layer. Since the density of the liquid changes due to the temperature change of the liquid, part of the liquid moves upwards, and finally, fluid convection is generated. To further illustrate the advantage of the surface lattice resonance-based optofluidic device of the present invention in fluid dynamics, this embodiment compares the thermally induced fluid convection distribution of the surface lattice resonance-based optofluidic device and the local plasmon resonance-based optofluidic device, as shown in fig. 6. Fig. 6(a) and 6(b) are vertical and horizontal two-dimensional slice profiles of induced fluid convection around a surface lattice resonance-based optofluidic device and a localized plasmonic structure resonance-based optofluidic device under steady state conditions. Wherein the velocity vector and the streamline indicate the flowing direction of the liquid, and different colors indicate the temperature rise and the fluid velocity. In the vertical two-dimensional slice profile (in the x-z plane) of the fluid convection, it can be seen that the direction of fluid flow is away from the heat source, i.e. away from the position of the photo-fluidic device. In the vertical two-dimensional slice profile (in the x-y plane) of fluid convection, it can be seen that the fluid is flowing towards the heat source, i.e. close to the optofluidic device. FIG. 6(c) is a function of the average temperature rise over time of the liquid environment in two optofluidic systemsAnd (4) counting. Along with the increase of the irradiation time, the liquid environment temperature of the two systems rises rapidly and then gradually reaches a stable state about 4 microseconds. Fig. 6(d) depicts the fluid convection velocity over time induced at point (0, 200nm) by surface lattice resonance heating and localized plasmon resonance heating. It can be observed from fig. 6(c) that in steady state conditions, the surface lattice resonance-based optofluidic device induced a temperature change of about 86K, whereas the local plasmon resonance-based optofluidic device induced a temperature increase of only 20K. Correspondingly, as can be seen from FIG. 6(d), the maximum flow velocity of the convection of the fluid induced by the surface lattice resonance heating reached 0.01nm/s, and the maximum flow velocity of the convection of the fluid induced by the localized plasmon resonance heating reached 7.9X 10-3nm/s. As in the trend of fig. 6(c), the convection velocity of the fluid in the two optofluidic devices gradually stabilizes after increasing. Fig. 6(c) and 6(d) show that the surface lattice resonance-based optofluidic device, whether it is at steady-state speed or the speed of fluid convection induced by photothermal response, is greater than the localized plasmon resonance-based optofluidic device.
Example 2
Based on embodiment 1, another optofluidic device based on surface lattice resonance is provided in the embodiments of the present application. As shown in fig. 7, substantially the same as in example 1, except that the periodic nanostructures are nanopyramids. Preferably, the nano-square disc has a side length of 240nm and a thickness of 40 nm.
Fig. 8,9 and 10 are absorption spectra, electromagnetic field distribution, light-induced temperature increase distribution and heat-induced fluid convection distribution of the optofluidic device based on surface lattice resonance in example 2 of the present invention, respectively, and it can be seen from fig. 8,9 and 10 that the photo-thermal response, i.e. the amount of heat generated, of the optofluidic device is increased by increasing the area of the metal nanostructure relative to the area of the circular disk without changing the resonance, so that the flow rate of the fluid convection caused by the photo-thermal effect of the surface lattice resonance is increased.
Example 3
Based on the optical flow control device based on surface lattice resonance disclosed in embodiments 1 and 2, the present embodiment discloses an application of the optical flow control device based on surface lattice resonance in disease diagnosis and treatment, specifically including the following steps:
step 3, mixing the antibody-modified large-size nano structure into a micro-flow chamber;
step 5, the fluorescent-labeled nanostructure modified by the antigen and the nanostructure modified by the antibody collide under the action of convection and fully perform antigen-antibody reaction, at the moment, the nanostructure with the specific antigen is attached to the nanostructure of the antibody to form a larger aggregation structure, moves along a flow line under the action of convection and finally aggregates near the light flow control device;
and 6, closing the laser, carrying out fluorescence detection on the gathering structure gathered near the optical flow control device, and judging whether the antigen and the antibody react according to whether the antigen is detected so as to finish the detection of the antibody.
Wherein small-sized nanostructures refer to nanostructures with a size of 6nm or less; large-sized nanostructures refer to nanostructures greater than 6nm in size; the aggregation structure is a conjugate of an antigen-modified fluorescently labeled nanostructure and an antibody-modified nanostructure.
Optionally, the height of the microfluidic chamber is 2cm to 4 cm.
Optionally, the nanostructures are polystyrene spheres.
Optionally, the polystyrene spheres have a diameter of 2 to 10 nm.
The above is only a preferred embodiment of the present invention, and it should be noted that the above preferred embodiment should not be considered as limiting the present invention, and all technical solutions falling within the spirit of the present invention belong to the protection scope of the present invention. It will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and these modifications and adaptations should be considered within the scope of the invention.
Claims (9)
1. The utility model provides a optofluidic device based on surface lattice resonance, includes substrate layer (10), thin film layer (20), periodic nanostructure layer (30), thin film layer (20) set up on the substrate layer, periodic nanostructure layer (30) set up on the thin film layer, periodic nanostructure layer (30) comprise the little nano structure of periodic arrangement, its characterized in that: the surface lattice resonance-based optofluidic device further comprises a liquid environmental layer (40), the liquid environmental layer (40) being arranged on the periodic nanostructure layer (30) for converting heat generated by the device into convection.
2. The surface lattice resonance-based optofluidic device of claim 1, wherein: the thin film layer (20) is a high thermal conductivity material and is used for effectively diffusing heat generated by the periodic nanostructure layer (30) arranged on the thin film layer, and meanwhile, the heat dissipation of the thin film layer (20) can increase the spatial range of temperature distribution and improve the photo-thermal response, so that the flow velocity of fluid convection induced by the thermal response is improved.
3. The surface lattice resonance-based optofluidic device of claim 2, wherein: the thin film layer (20) is a graphite or gold thin film.
4. The surface lattice resonance-based optofluidic device of any one of claims 1 to 3, wherein: the periodic nanostructure layer (30) is composed of a plurality of nano discs with the radius of 70-170nm and the thickness of 20-80nm, the nano discs are arranged according to a periodic square structure or hexagonal structure in space, and the gap between adjacent nano discs is 550-620 nm.
5. The surface lattice resonance-based optofluidic device of any one of claims 1 to 3, wherein: the periodic nano-structure layer (30) is composed of a plurality of nano-square discs with the side length of 140-340nm and the thickness of 20-80nm, the nano-square discs are arranged according to a periodic square structure or hexagonal structure in space, and the gap between adjacent nano-square discs is 550-620 nm.
6. Use of a surface lattice resonance-based optofluidic device for diagnosis and treatment of diseases, realized based on the surface lattice resonance-based optofluidic device of any one of claims 1 to 5, comprising the steps of:
step 1, placing the surface lattice resonance-based optical flow control device in a microfluidic chamber of a liquid environment;
step 2, mixing the antigen-modified nano-structure with the size less than or equal to 6 into the micro-flow chamber, and marking the small-size nano-structure by using fluorescence;
step 3, mixing the antibody-modified nano structure with the size larger than 6 into the micro-flow chamber;
step 4, irradiating the optofluidic device by laser to generate fluid convection in the microfluidic chamber, wherein the fluorescent-labeled nanostructure modified by the antigen and the nanostructure modified by the antibody collide under the action of the convection and fully perform antigen-antibody reaction, and the nanostructure with the specific antigen is attached to the nanostructure modified by the antibody to form an aggregation structure and moves along a flow line under the action of the convection to enable the aggregation structure to aggregate near the optofluidic device;
and 5, closing the laser, carrying out fluorescence detection on the aggregation structure aggregated near the optical flow control device, and judging whether the antigen and the antibody react according to whether the antigen is detected so as to finish the detection of the antibody.
7. Use of a surface lattice resonance based optofluidic device according to claim 6 for diagnosis and treatment of diseases, wherein: the nanostructures are polystyrene spheres.
8. Use of a surface lattice resonance based optofluidic device according to any one of claims 6-7 in medical diagnostics, wherein: the height of the microfluidic chamber is 2-4 cm.
9. Use of a surface lattice resonance based optofluidic device according to claim 7 for diagnosis and treatment of diseases, wherein: the diameter of the polystyrene sphere is 2-10 nm.
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