CN104645253A - Patch for preventing and treating dyspepsia - Google Patents

Abstract

The invention belongs to the technical field of medicines, and discloses a patch for preventing and treating dyspepsia. The patch is prepared from the following raw materials: astragalus mongholicus, mulberry leaves, glutinous rice, honeysuckle, hawthorn, cortex magnoliae officinalis, myrrh, rhizoma zedoariae, Chinese yam, radix scutellariae, fructus aurantii immaturus, pericarpium citri reticulatae, poria cocos, fructus lycii, salvia miltiorrhiza, chrysanthemum, radix bupleuri, radix paeoniae alba, liquorice, cassia twigs, rhizoma cyperi, cinnamomum cassia, fructus amomi, endothelium corneum gigeriae galli and dandelion. The patch is good in dyspepsia treatment effect, low in toxic and side effects and low in cost.

Description

For the dyspeptic patch of prevention and therapy

Technical field

The invention belongs to medical art, be specifically related to for the dyspeptic patch of prevention and therapy.

Background technology

Dyspepsia, refers to have the malaise symptoms such as upper abdominal pain, big belly, early full, belch, inappetence, Nausea and vomiting, gets rid of the one group of clinical syndrome causing the organic disease of above-mentioned symptom on inspection.Sustainable or the recurrent exerbation of symptom, dyspepsia has been modal a kind of functional gastrointestinal disorder clinically.

Dyspepsia atypism belongs to common disease in children disease, and it is similar with adult's symptom, main clinical manifestation, mainly contains upper abdominal pain, big belly, early full, belch, inappetence, Nausea and vomiting etc.Can occur separately or with one group of symptom.Mainly comprise: early satisfy after referring to feed and namely have full sense soon, so that dietary intake obviously reduces; Big belly is multiple to be born in after the meal, or in persistence dining postemphasis; Early saturated big belly is often with belch; Nausea and vomiting is uncommon, often occurs in the patient that gastric emptying obviously postpones, and vomiting mostly is when meal gastric content; Many patients is simultaneously with insomnia, anxiety, depression, headache, the mental symptom such as absent minded; In the course of disease, symptom also can change, and how slow, for years onset is, persistence or recurrent exerbation, the risk factors such as many patients have diet, spirit.

The Western medicine huge number of current treatment dyspepsia disease, as gastric acid inhibitory class medicine, improves gastric motility medicine etc., although instant effect, good effect, but all there is certain side effect, and cure the symptoms, not the disease, Chinese medicine is little with its toxic and side effects, and the occupancy volume of the market share expands year by year.Seek a kind of high-efficiency low-toxicity, treating both the principal and secondary aspects of a disease, Chinese Traditional Medicines with low cost put a technical barrier in face of medical circle at home.

Summary of the invention

Present inventor is according to forefathers' experience and oneself medical practice for many years, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways the length of many families is collected, seek therapeutic regimen, be meticulously mixed with the dyspeptic pharmaceutical preparation of prevention and therapy of the present invention in conjunction with Traditional Chinese Medicine technology, dyspepsia had to the effect of taking stopgap measures and effecting a permanent cure, and toxic and side effects is low, with low cost.

For achieving the above object, the technical solution used in the present invention is as follows:

For the dyspeptic patch of prevention and therapy, it is prepared from by following raw material:

The Radix Astragali, Folium Mori, Semen oryzae sativae, Flos Lonicerae, Fructus Crataegi, Cortex Magnoliae Officinalis, Myrrha, Rhizoma Curcumae, Rhizoma Dioscoreae, Radix Scutellariae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Poria, Fructus Lycii, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Radix Bupleuri, the Radix Paeoniae Alba, Radix Glycyrrhizae, Ramulus Cinnamomi, Rhizoma Cyperi, Cortex Cinnamomi, Fructus Amomi, Endothelium Corneum Gigeriae Galli, Herba Taraxaci.

Particularly, it is prepared from by the raw material of following weight portion:

The Radix Astragali 30 parts, 28 parts, Folium Mori, Semen oryzae sativae 26 parts, Flos Lonicerae 25 parts, Fructus Crataegi 22 parts,

Cortex Magnoliae Officinalis 20 parts, Myrrha 18 parts, Rhizoma Curcumae 16 parts, Rhizoma Dioscoreae 16 parts, Radix Scutellariae 15 parts,

Fructus Aurantii Immaturus 13 parts, Pericarpium Citri Reticulatae 12 parts, 12 parts, Poria, Fructus Lycii 10 parts, Radix Salviae Miltiorrhizae 10 parts,

Flos Chrysanthemi 9 parts, Radix Bupleuri 9 parts, the Radix Paeoniae Alba 8 parts, 8 parts, Radix Glycyrrhizae, Ramulus Cinnamomi 8 parts,

Rhizoma Cyperi 7 parts, Cortex Cinnamomi 6 parts, Fructus Amomi 4 parts, Endothelium Corneum Gigeriae Galli 2 parts, Herba Taraxaci 1 part.

The preparation technology of above-mentioned patch comprises the steps:

(1) each raw material is taken according to weight portion, for subsequent use;

(2) Radix Astragali is got, Folium Mori, Semen oryzae sativae, Flos Lonicerae, Fructus Crataegi, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Poria, Fructus Lycii, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, mixing, add relative to mixture 5 times of weight 80%(v/v) soak with ethanol 24 hours, then reflux, extract, 2 hours, collects extracting solution, be condensed into the extractum that density is 1.2g/mL, be complex 1;

(3) get surplus stock, mixing, by water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour, collecting by filtration filtrate and filtering residue; Second time extracts the water adding 2 times of weight in filtering residue, and extraction time is 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, be concentrated into the extractum that density is 1.2g/mL, be complex 2;

(4) by complex 1 and complex also 2-in-1, stir, be then split on non-woven fabrics, be prepared into patch, the area of non-woven fabrics is 15 be multiplied by 10cm; Sharing dosage is the every block non-woven fabrics of 5g/.

Method of application: be affixed on umbilicus place, changes once for every 24 hours.

Technical solutions according to the invention are on the dyspeptic clinical experience basis of Chinese traditional treatment, the dialectical acquisition technical scheme of the length in conjunction with many families, the advantages such as it has treating both the principal and secondary aspects of a disease, and toxic and side effects is little, with low cost.

The dosage form reasonable recipe of patch of the present invention, compatibility is simplified, and clinical practice reaction is fine, preparation technology's simple possible, and adopts different material Different treatments, releases drug effect to greatest extent.

Detailed description of the invention

Technical scheme in the application is understood better in order to make those skilled in the art person, below in conjunction with the application's specific embodiment, carry out clearly, intactly describing to the present invention, obviously, described embodiment is only some embodiments of the present application, instead of whole embodiments.Based on the embodiment in the application, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, should belong to the scope of protection of the invention.

Embodiment 1

For the dyspeptic patch of prevention and therapy, it is prepared from by the raw material of following weight portion:

The Radix Astragali 30 parts, 28 parts, Folium Mori, Semen oryzae sativae 26 parts, Flos Lonicerae 25 parts, Fructus Crataegi 22 parts,

Cortex Magnoliae Officinalis 20 parts, Myrrha 18 parts, Rhizoma Curcumae 16 parts, Rhizoma Dioscoreae 16 parts, Radix Scutellariae 15 parts,

Fructus Aurantii Immaturus 13 parts, Pericarpium Citri Reticulatae 12 parts, 12 parts, Poria, Fructus Lycii 10 parts, Radix Salviae Miltiorrhizae 10 parts,

Flos Chrysanthemi 9 parts, Radix Bupleuri 9 parts, the Radix Paeoniae Alba 8 parts, 8 parts, Radix Glycyrrhizae, Ramulus Cinnamomi 8 parts,

Rhizoma Cyperi 7 parts, Cortex Cinnamomi 6 parts, Fructus Amomi 4 parts, Endothelium Corneum Gigeriae Galli 2 parts, Herba Taraxaci 1 part.

The preparation technology of above-mentioned patch comprises the steps:

(1) each raw material is taken according to weight portion, for subsequent use;

(2) Radix Astragali is got, Folium Mori, Semen oryzae sativae, Flos Lonicerae, Fructus Crataegi, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Poria, Fructus Lycii, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, mixing, add relative to mixture 5 times of weight 80%(v/v) soak with ethanol 24 hours, then reflux, extract, 2 hours, collects extracting solution, be condensed into the extractum that density is 1.2g/mL, be complex 1;

(3) get surplus stock, mixing, by water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour, collecting by filtration filtrate and filtering residue; Second time extracts the water adding 2 times of weight in filtering residue, and extraction time is 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, be concentrated into the extractum that density is 1.2g/mL, be complex 2;

(4) by complex 1 and complex also 2-in-1, stir, be then split on non-woven fabrics, be prepared into patch, the area of non-woven fabrics is that 15cm is multiplied by 10cm; Sharing dosage is the every block non-woven fabrics of 5g/.

Method of application: be affixed on umbilicus place, changes once for every 24 hours.

Embodiment 2

Irritation test

By 10 rabbit, with 10% sodium sulfide to family's rabbit back depilation, unhairing area is about 150cm ²the patch sticking embodiment 1 preparation is also fixed with nonirritant adhesive plaster in depilation district, every animal sub-cage rearing, administration after 24 hours 1,24,48,72 little of the 7th day, observe every day and record the change of the body weight of animal, fur, gloss, diet, eye and mucosa, the activity of respiratory center, nervous system, extremity and death condition, and put to death rabbit after Yu Qi, the change of the internal organs such as its heart of anatomic observation, liver, spleen, lung, kidney.

Result: the present invention prepares patch to the behavior of damaged skin rabbit, activity, diet, fur gloss, respiratory center, nervous system and body weight without any harmful effect, and none rabbit is dead.Rabbit is put to death, the main organs no abnormality seens such as its heart of anatomic observation, liver, spleen, lung, kidney after seven days.Therefore patch of the present invention does not all cause acute toxic reaction to rabbit on damaged skin.

Embodiment 3

Clinical data

Choose clinical infantile dyspepsia 80 example, the age 1-5 year, the course of disease is the shortest three days, the longest 2 weeks, is divided into two groups at random, matched group 40 example, use DINGHUIER QITIE, treatment group 40 example use embodiment 1 preparation patch.

Diagnostic criteria: clinical manifestation is that large loose stool is thin, number of times increase or smelly dirty unpleasant, or accompany lump in breast and food debris, but just routine examination is normal, or with hypotrichosis, emaciation and sallow complexion, tired etc.

Therapeutic Method: treatment group sticks patch prepared by embodiment 1; Matched group sticks DINGHUIER QITIE; Be three days courses for the treatment of; Matched group and treatment group take conventional bacillus subtilis bigeminy viable bacteria granular adjustment intestinal microbial population all simultaneously.

Curative effect judging standard: cure: after 1-2 course for the treatment of, stool transfers to normal, clinical symptom disappearance.Effective: after 1-2 course for the treatment of, stool is close to normal, and clinical symptoms is improved.Invalid: after 1-2 course for the treatment of, stool and clinical symptoms are without improvement.

Therapeutic effect is in table 1:

Table 1

Conclusion: treatment group and matched group exist extremely significant difference on cure rate and total effective rate.

Although above done detailed explanation with general explanation and detailed description of the invention to this case, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, amendment done without departing from theon the basis of the spirit of the present invention or improvement, all belong to the scope of protection of present invention.

Claims (4)

1. for the dyspeptic patch of prevention and therapy, it is characterized in that, described patch is prepared from by following raw material:

The Radix Astragali, Folium Mori, Semen oryzae sativae, Flos Lonicerae, Fructus Crataegi, Cortex Magnoliae Officinalis, Myrrha, Rhizoma Curcumae, Rhizoma Dioscoreae, Radix Scutellariae, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Poria, Fructus Lycii, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, Radix Bupleuri, the Radix Paeoniae Alba, Radix Glycyrrhizae, Ramulus Cinnamomi, Rhizoma Cyperi, Cortex Cinnamomi, Fructus Amomi, Endothelium Corneum Gigeriae Galli, Herba Taraxaci.

2. patch according to claim 1, is characterized in that, described patch is prepared from by the raw material of following weight portion:

The Radix Astragali 30 parts, 28 parts, Folium Mori, Semen oryzae sativae 26 parts, Flos Lonicerae 25 parts, Fructus Crataegi 22 parts,

Cortex Magnoliae Officinalis 20 parts, Myrrha 18 parts, Rhizoma Curcumae 16 parts, Rhizoma Dioscoreae 16 parts, Radix Scutellariae 15 parts,

Fructus Aurantii Immaturus 13 parts, Pericarpium Citri Reticulatae 12 parts, 12 parts, Poria, Fructus Lycii 10 parts, Radix Salviae Miltiorrhizae 10 parts,

Flos Chrysanthemi 9 parts, Radix Bupleuri 9 parts, the Radix Paeoniae Alba 8 parts, 8 parts, Radix Glycyrrhizae, Ramulus Cinnamomi 8 parts,

Rhizoma Cyperi 7 parts, Cortex Cinnamomi 6 parts, Fructus Amomi 4 parts, Endothelium Corneum Gigeriae Galli 2 parts, Herba Taraxaci 1 part.

3. patch according to claim 1, is characterized in that, the preparation technology of described patch comprises the steps:

(1) each raw material is taken according to weight portion, for subsequent use;

(2) Radix Astragali is got, Folium Mori, Semen oryzae sativae, Flos Lonicerae, Fructus Crataegi, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Poria, Fructus Lycii, Radix Salviae Miltiorrhizae, Flos Chrysanthemi, mixing, add relative to mixture 5 times of weight 80% soak with ethanol 24 hours, then reflux, extract, 2 hours, collect extracting solution, be condensed into the extractum that density is 1.2g/mL, be complex 1;

(3) get surplus stock, mixing, by water boiling and extraction 2 times, first time extracts the water adding 5 times of weight, and extraction time is 1 hour, collecting by filtration filtrate and filtering residue; Second time extracts the water adding 2 times of weight in filtering residue, and extraction time is 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, be concentrated into the extractum that density is 1.2g/mL, be complex 2;

(4) by complex 1 and complex also 2-in-1, stir, be then split on non-woven fabrics, be prepared into patch.

4. claim 1-3 lets alone the application of patch in treatment dyspepsia described in.