CN104645111A - Nasopharyngeal carcinoma liver soothing and depression resolving agent and preparation method thereof - Google Patents
Nasopharyngeal carcinoma liver soothing and depression resolving agent and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a nasopharyngeal carcinoma liver soothing and depression resolving agent. The nasopharyngeal carcinoma liver soothing and depression resolving agent is prepared from the following main raw materials in parts by weight: 15-30 parts of astragalus root, 15-20 parts of lotus root section, 15-20 parts of cogongrass rhizome, 8-15 parts of sunflower seeds, 8-15 parts of mango cores, 10-20 parts of cicada slough, 9-16 parts of garden balsam seed, 15-30 parts of fructus arctii, 15-20 parts of cocklebur fruits, 8-12 parts of seeds of Livistona chinensis, 8-12 parts of gardenia, 8-10 parts of tetrandra root, 9-12 parts of oroxylum indicum, 15-20 parts of medical stone and 10-20 parts of dandelion. The nasopharyngeal carcinoma liver soothing and depression resolving agent disclosed by the invention has the functions of qi benefiting, blood nourishing, damp adjusting, phlegm reducing, cancer resisting, swelling eliminating and hard lump softening and resolving, so that the nasopharyngeal carcinoma liver soothing and depression resolving agent disclosed by the invention has an obvious curative effect to nasopharyngeal carcinoma and is capable of rapidly inhibiting and killing cancer cells.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI and method for making.
Background technology
Nasopharyngeal carcinoma refers to the malignant tumor betiding cavum nasopharyngeum top and sidewall.Be one of China's malignant tumor occurred frequently, sickness rate is first of ear,nose & throat malignant tumor, male's sickness rate be the 2-3 of women doubly, 40-50 year be age group occurred frequently.Common symptoms is for being with blood, ear suffocation sense, auditory dysesthesia, diplopia and headache etc. in nasal obstruction, tears.
Its common sympton is: 1. sniffle: can occur in early days being with blood or blowing out in tears in retraction tears being with blood, cut in and out, how not cause patient to pay attention to, the continuous increase of tumor body can block nostril, causes nasal obstruction, begins as one-sided, bilateral then.2. ear's symptom: tumor betides pharyngeal recess person, can oppress in early days or block pharyngeal opening of auditory tube, and cause this pick up the ears ring, deafness and auditory dysesthesia, hydrotympanum, clinical easy mistaken diagnosis is secretory otitis media.3. cervical lymph node enlargement: Cervical Lymph Node Metastasis person is more common is that starting symptom accounts for 60% with deradenoncus, and the lymph of transfer enlargement becomes group's lymph node in throat depth portion, increase in Progressive symmetric erythrokeratodermia, the hard inertia of matter, without tenderness, begin, for one-sided, then to develop into bilateral.4. cranial nerve symptom: tumor body by foramen lacerum Intracranial invasion, often first invades V, VI cranial nerve through Ipsilateral pharyngeal recess, then involves II, III, IV cranial nerve and has a headache, facial numbness, the cranial nerve such as eyeball abduction is limited, the ptosis are got involved symptom; Due to the direct infringement of tumor body or there is soft palate paralysis because Ⅸ, Ⅹ, Ⅺ, Ⅻ cranial nerve all can be caused impaired for metastatic lymph node compressing, choke cough, hoarseness, loll the symptoms such as deflection.5. metastasis: transfer can appear in advanced NPC, and common person has bone, lung, liver etc.
The cause of disease of nasopharyngeal carcinoma may with following factors about 1. ebv infection: Epstein and Barr in 1964 establishes the lymphoblast strain that a strain can be gone down to posterity first from the biopsy of african children lymphoma (Burkitt lymphoma), visible herpes type virus granule under Electronic Speculum.From tissues of nasopharyngeal carcinoma separable go out viruliferous lymphoblastoid strain, minority is visible virion under Electronic Speculum.Immunology and biochemical research confirm Epstein-Barr virus and Nasopharyngeal Cancer closely, and the dynamic change of Epstein-Barr virus antibody titer and monitoring, can as clinical diagnosis, estimating prognosis and the index of following up a case by regular visits to monitoring.Except Epstein-Barr virus, other viruses, as coronavirus etc., are also considered to the generation evolution that take part in nasopharyngeal carcinoma.2. environment and diet: have the Chinese reporting and show and expatriate, its NPC mortality declines gradually with genetic algebra.Otherwise be born in the white people in Southeast Asia, its danger suffering from nasopharyngeal carcinoma but increases.Epidemiological study finds, the baby in Guangdong Province's high risky area of nasopharyngeal carcinoma, just has cured fish in the food first contacted after wean.In addition, dried fish, Guangdong cured meat and fish are also relevant with nasopharyngeal carcinoma sickness rate.These food all have nitrosamine precursor nitrite in curing process.The gastric juice pH of people is when 1-3, and nitrous acid or nitrate (need be reduced into nitrite through cell) can synthesize nitrosamine compound with the secondary amine in cell, and these materials have stronger carcinogenesis.Some trace element, as the content overproof in the environment such as nickel, also likely brings out nasopharyngeal carcinoma.3. inherited genetic factors: nasopharyngeal cancer patient has race and Familial aggregation phenomenon, the factor analysis offspring as lived in other countries still remains the sickness rate of high nasopharyngeal carcinoma, and this prompting nasopharyngeal carcinoma may be hereditary.In recent years, molecule genetics research finds, mainly 1,3,11,12 and No. 17 chromosome of nasopharyngeal carcinoma tumor cell generation chromosome change, finds that in nasopharyngeal carcinoma tumor cell the variation that there is multiple tumor antioncogene in nasopharyngeal carcinoma generation evolution may be pointed out by polysomy loss of heterozygosity district (1p, 9p, 9q, 11q, 13q, 14q and 16q).
At present, the medicine for the treatment of nasopharyngeal carcinoma is a lot, publication number CN 104324280 A (application number 201410679028.2) patent document discloses a kind of Chinese medicine composition for the treatment of nasopharyngeal carcinoma and preparation method thereof, comprise following medicine to be prepared from according to parts by weight: Rhizoma Polygonati Odorati 10-50 part, Cortex Fraxini 10-50 part, Radix Arnebiae (Radix Lithospermi) 5-40 part, Fructus Ligustri Lucidi 5-40 part, Cortex Lycii 5-25 part, Radix Rehmanniae 5-25 part, Fructus Xanthii 5-25 part, Pseudobulbus Cremastrae Seu Pleiones 10-40 part, Fructus Piperis Longi 5-25 part, Radix Adenophorae (Radix Glehniae) 10-50 part, Semen Cuscutae 10-40 part, Semen Coicis 10-30 part, Rhizoma Polygoni Cuspidati 5-25 part, Spica Prunellae 5-25 part, Concha Arcae 5-25 part.Publication number CN 103845613 A(application number 201210532689.3) patent document discloses a kind of Chinese medicine for the treatment of nasopharyngeal carcinoma, it is made up of the component of following weight portion: Herba Solani Nigri 20-40 gram, Radix Sophorae Tonkinensis 15-25 gram, Pseudobulbus Cremastrae Seu Pleiones 15-25 gram.Publication number CN 103920098 A(application number 201410192391.1) patent document discloses a kind of medicament for the treatment of nasopharyngeal carcinoma and preparation method thereof, be prepared from by the medical material of following weight proportion: Pseudobulbus Cremastrae Seu Pleiones 3-6 part, Herba Selaginellae Involventis 15-30 part, Caulis Akebiae 1-3 part, Matrii Sulfas Exsiccatus 3-7 part, Herba Trifolii Pratentis 0.5-1 part, Flos Chrysanthemi 5-9 part, Radix glochidionis puberi 0.5-2 part, Rhizoma Polygonati Odorati 6-12 part, Radix Peucedani 5-10 part, fine branch Chinese lime 3-5 part, Semen Litchi 6-10 part, Herba ajugae forrestii 3-5 part, Rhizoma Pinelliae 3-9 part, Folium Coreopsis lanceolatae 3-7 part, Rhizoma Curcumae 6-9 part, Radix Panacis Quinquefolii 0.8-2 part, Herba Tripterospermi 1-7 part, Folium Toddaliae Asiaticae 10-15 part, Herba Peristrophes 9-15 part, Radix Asparagi Officinalis 1-3 part, Radix vitis romanetii 5-7 part, Herba Hyperici perforati 2-3 part.
Current western medical treatment nasopharyngeal carcinoma many employings radiotherapy, chemotherapy, operative treatment, maximum be exactly radiotherapy, but radiotherapy often can produce the toxicities such as radiodermatitis, radiation esophagitis, appetite decline, nausea and vomiting, abdominal pain diarrhea or constipation.Chinese medicine has the following disadvantages: DeGrain, takes effect slow, can not effectively suppress throat tumor growth, metastasis and extension.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide the agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, has effect of benefiting qi and nourishing blood, reason humidifying expectorant, heat-clearing and toxic substances removing, anti-cancer and detumescence, hard masses softening and resolving, has obvious curative effect to nasopharyngeal carcinoma.Another object of the present invention is just to provide the preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 15-30 part; Nodus Nelumbinis Rhizomatis 15-20 part; Rhizoma Imperatae 15-20 part; Semen Helianthi 8-15 part; Fructus Mangifera Indicae core 8-15 part; Periostracum Cicadae 10-20 part; Semen Impatientis 9-16 part; Fructus Arctii 15-30 part; Fructus Xanthii 15-20 part; Seed of Livistona chinensis R.Br. 8-12 part; Fructus Gardeniae 8-12 part; Radix Stephaniae Tetrandrae 8-10 part; Semen Oroxyli 9-12 part; Maifanitum 15-20 part; Herba Taraxaci 10-20 part.
The agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 20-25 part; Nodus Nelumbinis Rhizomatis 16-19 part; Rhizoma Imperatae 16-19 part; Semen Helianthi 10-13 part; Fructus Mangifera Indicae core 10-13 part; Periostracum Cicadae 13-17 part; Semen Impatientis 11-14 part; Fructus Arctii 20-25 part; Fructus Xanthii 16-19 part; Seed of Livistona chinensis R.Br. 9-11 part; Fructus Gardeniae 9-11 part; Radix Stephaniae Tetrandrae 8.5-9.5 part; Semen Oroxyli 10-11 part; Maifanitum 16-19 part; Herba Taraxaci 13-17 part.
The agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from
:the Radix Astragali 22 parts; Nodus Nelumbinis Rhizomatis 18 parts; Rhizoma Imperatae 18 parts; Semen Helianthi 12 parts; Fructus Mangifera Indicae core 12 parts; Periostracum Cicadae 15 parts; Semen Impatientis 12 parts; Fructus Arctii 22 parts; Fructus Xanthii 18 parts; Seed of Livistona chinensis R.Br. 10 parts; Fructus Gardeniae 10 parts; Radix Stephaniae Tetrandrae 9 parts; Semen Oroxyli 10.5 parts; Maifanitum 18 parts; Herba Taraxaci 15 parts.
Present invention also offers the preparation method agent of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI being made pharmaceutically acceptable powder, decoction, pill, tablet and capsule.
The preparation method of described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent powder, step is as follows:
(1) Maifanitum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) put by Fructus Xanthii in parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dries in the air cool, grind deburring, smash to pieces, crosses 120-160 mesh sieve (preferred cross 130-150 mesh sieve, be more preferably 140 mesh sieves);
(3) Radix Astragali and Radix Stephaniae Tetrandrae are placed in boiling container, add water and rice vinegar, infiltrate 2-3 hour, slow fire heats, boil to vinegar liquid and be sucked, take out, dry in the air to 6 seventy percent dry, cut sheet, drying, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii and Herba Taraxaci are cleaned, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(6) by step (1)-(5) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
The preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent powder, the consumption of the preferred rice vinegar of step (3) is the 25%-35% of the Radix Astragali and Radix Stephaniae Tetrandrae gross mass, and the consumption being more preferably rice vinegar is 30% of the Radix Astragali and Radix Stephaniae Tetrandrae gross mass.
Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 20 days courses for the treatment of by the warm waters of about 50 DEG C.
The preparation method of described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent decoction, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) step (3) gains are joined in step (4) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, obtain decoction.
Instructions of taking: each 15-20ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 20 days courses for the treatment of.
The preparation method of described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent pill, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) join in step (4) gained filtrate by step (3) gains, mixing, is condensed into the thick paste that relative density is 1.10-1.30 and (is preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), dry, pulverize, obtain medicated powder;
(6) be placed in pot by Mel, slow fire is tempered to thick, adds step (5) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
The preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent pill, the consumption of the preferred Mel of step (6) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.
Instructions of taking: each 10-15 ball, every day 3 times, 20 days courses for the treatment of.
The preparation method of described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent tablet, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) step (3) gains are joined in step (4) gained filtrate, mixing, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, was more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.
Instructions of taking: each 2-3 sheet, every day 3 times, 20 days courses for the treatment of.
The preparation method of described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent capsules, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) join in step (4) gained filtrate by step (3) gains, mixing, is condensed into the thick paste that relative density is 1.10-1.20, dries, and pulverizes, obtains medicated powder;
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.
Instructions of taking: at every turn get 2-3 grain, every day 3 times, 20 days courses for the treatment of.
Technical advantage of the present invention is mainly reflected in:
1, each raw material effect of a kind of nasopharyngeal carcinoma of the present invention dispersing the stagnated live-QI to relieve the stagnation of QI agent is worked in coordination with, all medicine compatibilities, there is effect of benefiting qi and nourishing blood, reason humidifying expectorant, heat-clearing and toxic substances removing, anti-cancer and detumescence, hard masses softening and resolving, can suppress rapidly, kill and wound cancerous cell, thus make cancerous protuberance have different softening and reduce in the short time.
2, treatment by Chinese herbs can make up operative treatment, radiotherapy, chemotherapeutical deficiency.The traditional Chinese medical science, from organic conception, had both considered the treatment of local, and had taked again the method for the body resistance strengthening and constitution consolidating, all have important effect for the local symptom and overall health of patients improving Nasopharyngeal Carcinoma Patients.
3, the present invention is evident in efficacy, take 3-5 the course for the treatment of stable disease, control cancerous cell diffusion, transfer, progressively disappear.
4, selected materials great majority of the present invention are Chinese medicine material, and medical material is easy to get, and cost is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): the Radix Astragali 15 parts; Nodus Nelumbinis Rhizomatis 15 parts; Rhizoma Imperatae 15 parts; Semen Helianthi 8 parts; Fructus Mangifera Indicae core 8 parts; Periostracum Cicadae 10 parts; Semen Impatientis 9 parts; Fructus Arctii 15 parts; Fructus Xanthii 15 parts; Seed of Livistona chinensis R.Br. 8 parts; Fructus Gardeniae 8 parts; Radix Stephaniae Tetrandrae 8 parts; Semen Oroxyli 9 parts; Maifanitum 15 parts; Herba Taraxaci 10 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent powder, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;
(2) put by Fructus Xanthii in parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring, smash to pieces, cross 140 mesh sieves;
(3) Radix Astragali and Radix Stephaniae Tetrandrae are placed in boiling container, add water and rice vinegar (consumption of rice vinegar is 30% of the Radix Astragali and Radix Stephaniae Tetrandrae gross mass), infiltrate 2 hours, slow fire heats, boil to vinegar liquid and be sucked, take out, dry in the air to 6 seventy percent dry, cut sheet, drying, porphyrize, crosses 140 mesh sieves;
(4) be placed in pot by humus flava usta, moderate heat heats, and fries and presents flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cool, be ground into fine powder altogether, cross 140 mesh sieves;
(5) Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii and Herba Taraxaci are cleaned, dry, pulverize, cross 140 mesh sieves;
(6) by step (1)-(5) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 20 days courses for the treatment of by the warm waters of about 50 DEG C.
embodiment 2the agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, takes off the primary raw material stating weight proportion and is prepared from (every part of 18g): the Radix Astragali 30 parts; Nodus Nelumbinis Rhizomatis 20 parts; Rhizoma Imperatae 20 parts; Semen Helianthi 15 parts; Fructus Mangifera Indicae core 15 parts; Periostracum Cicadae 20 parts; Semen Impatientis 16 parts; Fructus Arctii 30 parts; Fructus Xanthii 20 parts; Seed of Livistona chinensis R.Br. 12 parts; Fructus Gardeniae 12 parts; Radix Stephaniae Tetrandrae 10 parts; Semen Oroxyli 12 parts; Maifanitum 20 parts; Herba Taraxaci 20 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent decoction, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, and discard impurity, merge suspension, leave standstill 3 hours, the clear water inclined above, gets precipitation and dry, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) be placed in pot by humus flava usta, moderate heat heats, and fries and presents flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cool, be ground into fine powder altogether, cross 140 mesh sieves;
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 35 minutes, add step (1)-(2) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) step (3) gains are joined in step (4) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, obtain decoction.
Instructions of taking: each 20ml, every day 3 times, 20 days courses for the treatment of.
model case onegrandson XX, man, 41 years old, Zaozhuang City of Shandong Province from Shanting District.Occur that cervical region swells thing without obvious inducement before about 3 years, originally smaller, similar one piece of Semen Viciae fabae size, without other any discomfort symptoms, so do not arouse attention, swollen thing increases gradually afterwards, feels sometimes and pain and constriction sometimes can occur hoarseness.Remove examination in hospital, find that left neck has the swollen thing of an about 3cm*3cm*2cm size, matter is real, neat in edge, with surrounding tissue without obvious adhesion, touches a tender spot.Give the treatment such as antiinflammatory and pain relieving, bad during symptom fashion.Transfer from one hospital to another afterwards, make a definite diagnosis nasopharyngeal carcinoma on inspection, Mr. Sun selects expectant treatment, sustainable expectant treatment nearly a year, without being clearly better.
After taking 2 courses for the treatment of of gained nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent decoction (embodiment 2) of the present invention, lump obviously reduces, and pain and constriction obviously alleviate.Continue to take 2 courses for the treatment of, the basic cancellation of lump, all malaise symptoms are all eased, and the mental status is good.Tracing observation is learnt and is fully recovered, without recurrence.
embodiment 3the agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): the Radix Astragali 20 parts; Nodus Nelumbinis Rhizomatis 16 parts; Rhizoma Imperatae 16 parts; Semen Helianthi 10 parts; Fructus Mangifera Indicae core 10 parts; Periostracum Cicadae 13 parts; Semen Impatientis 11 parts; Fructus Arctii 20 parts; Fructus Xanthii 16 parts; Seed of Livistona chinensis R.Br. 9 parts; Fructus Gardeniae 9 parts; Radix Stephaniae Tetrandrae 8.5 parts; Semen Oroxyli 10 parts; Maifanitum 16 parts; Herba Taraxaci 13 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent pill, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, and discard impurity, merge suspension, leave standstill 3 hours, the clear water inclined above, gets precipitation and dry, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) be placed in pot by humus flava usta, moderate heat heats, and fries and presents flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cool, be ground into fine powder altogether, cross 140 mesh sieves;
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 35 minutes, add step (1)-(2) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) join in step (4) gained filtrate by step (3) gains, mixing, is condensed into the thick paste that relative density is 1.20, dries, and pulverizes, obtains medicated powder;
(6) be placed in pot by Mel (consumption of Mel is 35% of medicated powder quality), slow fire is tempered to thick, adds step (5) gained medicated powder, fully mixes into ointment thoroughly, makes the pill that diameter is 4mm.
Instructions of taking: each 10 balls, every day 3 times, 20 days courses for the treatment of.
embodiment 4the agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, takes off the primary raw material stating weight proportion and is prepared from (getting 25g for every part): the Radix Astragali 25 parts; Nodus Nelumbinis Rhizomatis 19 parts; Rhizoma Imperatae 19 parts; Semen Helianthi 13 parts; Fructus Mangifera Indicae core 13 parts; Periostracum Cicadae 17 parts; Semen Impatientis 14 parts; Fructus Arctii 25 parts; Fructus Xanthii 19 parts; Seed of Livistona chinensis R.Br. 11 parts; Fructus Gardeniae 11 parts; Radix Stephaniae Tetrandrae 9.5 parts; Semen Oroxyli 11 parts; Maifanitum 19 parts; Herba Taraxaci 17 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent tablet, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, and discard impurity, merge suspension, leave standstill 3 hours, the clear water inclined above, gets precipitation and dry, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) be placed in pot by humus flava usta, moderate heat heats, and fries and presents flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cool, be ground into fine powder altogether, cross 140 mesh sieves;
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 35 minutes, add step (1)-(2) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) join in step (4) gained filtrate by step (3) gains, mixing, is condensed into the thick paste that relative density is 1.20, with fashion of extrusion by 22 eye mesh screens, makes single-size, dry, is pressed into lamellar, sugar coating.
Instructions of taking: each 2-3 sheet, every day 3 times, 20 days courses for the treatment of.
model case twoconsolidate XX, man, 56 years old, people from Chiping County, Liaocheng of Shandong Province.Remove hospital admission because of nasal mucus band blood before about 5 years, the inspection of conchoscope biopsy pathology is shown: squamous cell carcinoma.After a radiotherapy, nasal mucus band mass formed by blood stasis shape is eased, but find after 1 wheat harvesting period that left neck has an enclosed mass, be thought of as nasopharyngeal carcinoma lymph metastasis, so row radiotherapy first quarter moon again, skin of neck ulceration is there is after result radiotherapy, suppurate, pus foul smelling, gives the anti symptom treatment such as antiinflammatory, to suppurate minimizing, but wound heals not yet.Have a medical check-up: albumin 20g/L, give infusion albumin etc.Continued treatment is half a year nearly, bad during symptom fashion, and be not completely recovered, yellowish complexion is become thin, the enlargement of left side face, and the diabrosis of left neck large area, has a little purulent secretion.
After taking 2 courses for the treatment of of gained nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent tablet (embodiment 4) of the present invention, symptom obviously alleviates, and sleep takes a turn for the better, and appetite starts to recover, and lump obviously reduces.After continuing to take 2 courses for the treatment of, go examination in hospital CT to show: nasopharynx part enclosed mass disappears, whole body does not find transfer.Later stage follows up a case by regular visits to and learns that period does not take other any medicines, and pass by for many years, the state of an illness does not recur, without transfer.
embodiment 5the agent of a kind of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): the Radix Astragali 22 parts; Nodus Nelumbinis Rhizomatis 18 parts; Rhizoma Imperatae 18 parts; Semen Helianthi 12 parts; Fructus Mangifera Indicae core 12 parts; Periostracum Cicadae 15 parts; Semen Impatientis 12 parts; Fructus Arctii 22 parts; Fructus Xanthii 18 parts; Seed of Livistona chinensis R.Br. 10 parts; Fructus Gardeniae 10 parts; Radix Stephaniae Tetrandrae 9 parts; Semen Oroxyli 10.5 parts; Maifanitum 18 parts; Herba Taraxaci 15 parts.
The preparation method of above-mentioned nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent capsules, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2 times, and discard impurity, merge suspension, leave standstill 3 hours, the clear water inclined above, gets precipitation and dry, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) be placed in pot by humus flava usta, moderate heat heats, and fries and presents flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cool, be ground into fine powder altogether, cross 140 mesh sieves;
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 35 minutes, add step (1)-(2) gains, decoct twice, boil 35 minutes at every turn, twice filtrate merges;
(5) join in step (4) gained filtrate by step (3) gains, mixing, is condensed into the thick paste that relative density is 1.15, dries, and pulverizes, obtains medicated powder;
(6) step (5) gained medicated powder is made capsule by the specification of 0.5g/ grain.
Instructions of taking: each 2-3 grain, every day 3 times, 20 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Astragali: sweet in the mouth, warm in nature.Return lung, spleen channel.For the dry root of leguminous plant Radix Astagali or Radix Astragali.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
Nodus Nelumbinis Rhizomatis: sweet in the mouth, puckery, property is put down.Return liver, lung, stomach warp.For the dry root stipes portion of nymphaeaceae plant lotus.There is hemostasis, effect of repercussive, for spitting blood, spitting of blood, epistaxis, hematuria, metrorrhagia.
Rhizoma Imperatae: sweet in the mouth, cold in nature.Return lung, stomach, urinary bladder channel.For the dry rhizome of grass Herba Imperatae, Arundoin, Coixol, fernenol, simiarenol, Isoarborinol, Anemonin, also containing sterols: stigmasterol, cupreol, campesterol, saccharide, volume sucrose, glucose and a small amount of fructose, xylose, simple acids: citric acid, oxalic acid and malic acid.There is cooling blood for hemostasis, effect of heat-clearing and toxic substances removing.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, acute nephritis edema, dysuria, gastric heat is vomitted the sound of vomiting, coughs.
Semen Helianthi: sweet in the mouth, property is put down.For the seed of feverfew Helianthi.Fatty oil can reach about 50%, in have volume linoleic acid to reach 70%, still have the sterol such as phospholipid, cupreol.In kernel, the major part (58%) of sugar is monosaccharide and disaccharide and the trisaccharide of solubility, not starch-containing, still containing the organic acid such as citric acid, tartaric acid, chlorogenic acid, quininic acid, caffeic acid and beta-carotene, phytin., 3,4-benzene a pair of horses going side by side pyrenes.There is rash, dysentery relieving, effect of saturating pus of carbuncle.Send out not saturating for rash, dysentery, chronic osteomyelitis, dysentery, impetigo, hyperlipemia, arteriosclerosis, cancer, atherosclerosis, hypertension, coronary heart disease, neurasthenia.
Fructus Mangifera Indicae core: bitter in the mouth, property is put down.For the pit of Anacardiaceae Zhi Wu Fructus Mangifera Indicae.Kernel fatty 5.2%, wherein saturated glyceride accounts for 14%, monoolein 24%, diolein 61%, glycerol three unsaturated acid ester 1% be weak; Its fatty acid composition is: stearic acid 34%, oleic acid 50%, and Palmic acid, arachidic acid and a small amount of myristic acid.Still containing sitosterol and volume starch.There is the kidney invigorating, the effect of renal cold of dispelling.For hernia, colic, dyspepsia, suffers from a deficiency of the kidney, renal cold, lumbago and skelalgia.
Periostracum Cicadae: sweet in the mouth, cold in nature.Return lung, Liver Channel.Exuviae shell when nymph for cicada Cryptotympana atrata Fabr. sprouts wings.There is loose wind heat extraction, sore-throat relieving, rash, nebula removing, effect of spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion buckwheat hinders, convulsion with spasms, tetanus.
Semen Impatientis: mildly bitter flavor, pungent, warm in nature.Return lung, Liver Channel.For the dry mature seed of Balsaminaceae plant Flos Impatientis.There is removing blood stasis softening the hard mass, effect of removing food stagnancy.Yong Yu mass in the abdomen mass in the abdomen, amenorrhea, dysphagic.
Fructus Arctii: acrid in the mouth, hardship, cold in nature.Attach to the lung and stomach meridians.For the dry mature fruit of feverfew Fructus Arctii.There is dispelling wind and heat pathogens, lung qi dispersing rash, effect of resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, cheek erysipelas of itching, carbuncle sore tumefacting virus.
Fructus Xanthii: acrid in the mouth, hardship, warm in nature.Return lung meridian.For the fruit of the drying and ripening band involucre of feverfew Herba Xanthii.There is the dehumidifying of loose wind, effect of clearing the nasal passage.For headche due to wind-cold, nasal sinusitis watery nasal discharge, rubella pruritus, arthralgia chiefly caused by damp pathogen contracture.
Seed of Livistona chinensis R.Br.: sweet in the mouth, puckery, property is put down.Return lung, liver, kidney, stomach warp.For the seed of plant Palmae Semen livistonae chinensis.Containing phenols, reducing sugar, tannin and triglyceride.Have relieve internal heat anticancer, repercussive hemostasis effect.For nasopharyngeal carcinoma, esophageal carcinoma, pulmonary carcinoma, chorionic epithelioma, cerebroma, leukemia, malignant mole, leukemia etc.
Fructus Gardeniae: bitter in the mouth, cold in nature.GUIXIN, lung, tri-jiao channel.Another name SHANZHIZI etc.For the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae.There is pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, effect of removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, yellow cellulitis dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.
Radix Stephaniae Tetrandrae: bitter in the mouth, cold in nature.Return bladder, spleen, kidney channel.For the dry root of menispermaceous plants Radix stephaniae tetrandrae.There is inducing diuresis to remove edema, wind-expelling pain-stopping, analgesia, antipyretic, antiinflammatory, of flaccid muscles, diuresis, antianaphylaxis shock and the effect reduced blood pressure.For edema beriberi, dysuria, eczema sore, rheumatic arthralgia, brothers' contraction is anxious, and flaccid pulmonary dyspnea is coughed, summer vomiting and diarrhea, and scabies skin ulcer swells, vascular hypertension.
Semen Oroxyli: bitter in the mouth, sweet, cool in nature.Return lung, liver, stomach warp.For the dry mature seed of Bignoniaceae plant oroxylum indicum.There is removing heat from the lung and relieving sorethroat, effect of dispersing the stagnated liver-QI for regulating the stomach.For cough due to lung-heat, sore throat, hoarseness, stomachache due to hyperactive liver-QI attacking the stomach.
Maifanitum: sweet in the mouth, warm in nature.For Acid-intermediate igneous rock rocks beschtauite.Maifanitum main component has silicon dioxide, aluminium oxide, ferrum oxide, ferrous oxide, magnesium oxide, calcium oxide, sodium oxide, potassium oxide, titanium dioxide, phosphorus pentoxide, manganese oxide, carbon dioxide, and the trace element such as fluorine, sulfur, strontium, barium, copper, zinc.There is removing toxic substances and promoting granulation, effect of damp eliminating spleen invigorating.For carbuncle carbuncle on the back, acne, eczema, beriberi, miliaria, finger is chapped, chloasma, toothache, oral ulcer, rheumatic arthralgia, lumbago and backache, chronic hepatitis, gastritis, dysentery, diabetes, neurasthenia, wound is red and swollen, hypertension, senile sclerosis of blood vessels, tumor, lithangiuria.
Herba Taraxaci: bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.For feverfew Herba Taraxaci, alkali ground Herba Taraxaci or the dry herb belonging to several plants together.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, enterodynia, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
test examplein order to verify the curative effect of gained nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI of the present invention agent (embodiment 5), do contrast test in June ,-2011 in April, 2006:
General data: screen 280 routine Nasopharyngeal Carcinoma Patients in Duo Jia hospital, wherein male patient 186 people, female patient 94 people; Minimal ages 19 years old, max age 68 years old, 47.8 years old mean age; 19-30 year 49 people, 31-50 year 149 people, 51-68 year 82 people.Be divided into experimental group and matched group two groups (wherein experimental group 180 people at random, matched group 100 people), two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.
Diagnostic criteria: the performance that 1. can have nasal obstruction, blood tears, tinnitus, deafness, headache, diplopia and other cranial nerve palsy clinically.2. pharyngorhinoscopy: can see swollen thing in nasopharynx top, posterior wall of nasopharynx and pharyngeal recess, swollen thing be speckle, swell under tuberosity or film, and during wellability change, surface is canescence, coarse, ulcer, has hemorrhage.3. examination of castoff cells: get nasopharynx diseased region surface secretions and make smear, can cancerous cell be found.4. biopsy: get nasopharynx part neoplasm, the living tissue of metastasis makes pathologic finding, finds cancerous tissue hypertrophy.
Usage and dosage: experimental group takes gained nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent capsules of the present invention, each 2-3 grain, every day 3 times, 20 days courses for the treatment of.Matched group uses other medicine (as Cyclophosphamide for injection, hydrochloride for injection Bleomycin A5 etc.), wherein, and Cyclophosphamide for injection: adult's usual amounts: each 500-1000mg/m of body surface area is pressed in single medicine intravenous injection
2, add normal saline 20-30ml, vein pours, and 1 time weekly, is used in conjunction 2 times, and rest 1-2 week repeats, drug combination 500-600mg/m
2; Usual pediatric dose: each 10-15mg/kg of intravenous injection, add after normal saline 20ml dilutes and slowly inject, 1 time weekly, be used in conjunction 2 times, rest 1-2 week repeats.Hydrochloride for injection Bleomycin A5: the concentration injection of dissolving this product 4-15mg (tiring)/ml with the injection 5-20ml of the applicable vein use such as normal saline or glucose solution.
Criterion of therapeutical effect: cure: after 4 courses for the treatment of of medication, the transference cure such as nasal obstruction, blood tears, tinnitus, deafness, headache, diplopia, lump disappearance, biopsy does not have cancerous cell.Effective: after 4 courses for the treatment of of medication, the symptom such as nasal obstruction, blood tears, tinnitus, deafness, headache, diplopia is eased, and lump obviously reduces even to disappear, check and do not find cancer cell metastasis.Invalid: after 4 courses for the treatment of of medication, the symptom such as nasal obstruction, blood tears, tinnitus, deafness, headache, diplopia is without alleviation, and cancerous cell fails to control even diffusion or transfer preferably.
4 courses for the treatment of of medication treatment, observe latter 3 years for the treatment of.The Comparison of therapeutic of the matched group adopting other drug and the experimental group taking gained nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI of the present invention agent, result is as shown in table 1:
Table 1
As can be seen from Table 1, take the cure rate of gained nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI of the present invention agent up to 71.67%, effective percentage is up to 95.56%; And the cure rate taking other drug only 38%, effective percentage also only has 77%, and inefficiency is up to 23%.So the successful taking gained nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI of the present invention agent is better than the effect using other drug.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. the agent of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 15-30 part; Nodus Nelumbinis Rhizomatis 15-20 part; Rhizoma Imperatae 15-20 part; Semen Helianthi 8-15 part; Fructus Mangifera Indicae core 8-15 part; Periostracum Cicadae 10-20 part; Semen Impatientis 9-16 part; Fructus Arctii 15-30 part; Fructus Xanthii 15-20 part; Seed of Livistona chinensis R.Br. 8-12 part; Fructus Gardeniae 8-12 part; Radix Stephaniae Tetrandrae 8-10 part; Semen Oroxyli 9-12 part; Maifanitum 15-20 part; Herba Taraxaci 10-20 part.
2. nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI according to claim 1 agent, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Radix Astragali 20-25 part; Nodus Nelumbinis Rhizomatis 16-19 part; Rhizoma Imperatae 16-19 part; Semen Helianthi 10-13 part; Fructus Mangifera Indicae core 10-13 part; Periostracum Cicadae 13-17 part; Semen Impatientis 11-14 part; Fructus Arctii 20-25 part; Fructus Xanthii 16-19 part; Seed of Livistona chinensis R.Br. 9-11 part; Fructus Gardeniae 9-11 part; Radix Stephaniae Tetrandrae 8.5-9.5 part; Semen Oroxyli 10-11 part; Maifanitum 16-19 part; Herba Taraxaci 13-17 part.
3. nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI according to claim 1 agent, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: the Radix Astragali 22 parts; Nodus Nelumbinis Rhizomatis 18 parts; Rhizoma Imperatae 18 parts; Semen Helianthi 12 parts; Fructus Mangifera Indicae core 12 parts; Periostracum Cicadae 15 parts; Semen Impatientis 12 parts; Fructus Arctii 22 parts; Fructus Xanthii 18 parts; Seed of Livistona chinensis R.Br. 10 parts; Fructus Gardeniae 10 parts; Radix Stephaniae Tetrandrae 9 parts; Semen Oroxyli 10.5 parts; Maifanitum 18 parts; Herba Taraxaci 15 parts.
4., according to the arbitrary described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent of claim 1-3, it is characterized in that, the preparation method of described powder, step is as follows:
(1) Maifanitum is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(2) put by Fructus Xanthii in parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dries in the air cool, grind deburring, smash to pieces, crosses 120-160 mesh sieve (preferred cross 130-150 mesh sieve, be more preferably 140 mesh sieves);
(3) Radix Astragali and Radix Stephaniae Tetrandrae are placed in boiling container, add water and rice vinegar, infiltrate 2-3 hour, slow fire heats, boil to vinegar liquid and be sucked, take out, dry in the air to 6 seventy percent dry, cut sheet, drying, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(5) Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii and Herba Taraxaci are cleaned, dry, pulverize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(6) by step (1)-(5) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.
5. the preparation method of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent powder according to claim 4, is characterized in that: the consumption of the preferred rice vinegar of step (3) is the 25%-35% of the Radix Astragali and Radix Stephaniae Tetrandrae gross mass, and the consumption being more preferably rice vinegar is 30% of the Radix Astragali and Radix Stephaniae Tetrandrae gross mass.
6., according to the arbitrary described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) step (3) gains are joined in step (4) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, obtain decoction.
7., according to the arbitrary described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) join in step (4) gained filtrate by step (3) gains, mixing, is condensed into the thick paste that relative density is 1.10-1.30 and (is preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), dry, pulverize, obtain medicated powder;
(6) be placed in pot by Mel, slow fire is tempered to thick, adds step (5) gained medicated powder, fully mixes into ointment thoroughly, makes pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm).
8. the preparation method of nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent pill according to claim 7, is characterized in that: the consumption of the preferred Mel of step (6) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.
9., according to the arbitrary described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) step (3) gains are joined in step (4) gained filtrate, mixing, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, was more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.
10., according to the arbitrary described nasopharyngeal carcinoma dispersing the stagnated live-QI to relieve the stagnation of QI agent of claim 1-3, it is characterized in that, the preparation method of described capsule, step is as follows:
(1) smashed by Maifanitum, be placed in mortar, add clear water and grind to form pasty state, add water stirring, incline and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discards impurity, merges suspension, leave standstill 2-4 hour, the clear water inclined above, gets precipitation and dries, porphyrize;
(2) put by Fructus Xanthii in preheating parch container, moderate heat heats, and fries to surperficial buff thorn burnt, inner light yellow, takes out, dry in the air cool, grind deburring;
(3) humus flava usta is placed in pot, moderate heat heats, fry and present flexible state to humus flava usta, add Semen Helianthi, Fructus Mangifera Indicae core, Semen Impatientis, seed of Livistona chinensis R.Br., Fructus Gardeniae and Semen Oroxyli, fry and hang up one deck humus flava usta to medical material surface, take out, sieve removes native powder, cools, is ground into fine powder altogether, cross 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);
(4) Radix Astragali, Nodus Nelumbinis Rhizomatis, Rhizoma Imperatae, Periostracum Cicadae, Fructus Arctii, Radix Stephaniae Tetrandrae and Herba Taraxaci are cleaned, be placed in marmite, soak 30-40 minute, add step (1)-(2) gains, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;
(5) join in step (4) gained filtrate by step (3) gains, mixing, is condensed into the thick paste that relative density is 1.10-1.20, dries, and pulverizes, obtains medicated powder;
(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764324A (en) * | 2012-07-27 | 2012-11-07 | 金忠和 | Medicine composition for treating neoplastic diseases and improving immunity |
| CN103055214A (en) * | 2013-01-05 | 2013-04-24 | 马长林 | Traditional Chinese medicine for treating nasopharynx cancer by utilizing lepidogrammitis intermedia |
| CN103550719A (en) * | 2013-11-18 | 2014-02-05 | 梁轶聪 | Traditional Chinese medicinal composition for treating nasopharyngeal carcinoma |
-
2015
- 2015-03-11 CN CN201510104996.5A patent/CN104645111A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764324A (en) * | 2012-07-27 | 2012-11-07 | 金忠和 | Medicine composition for treating neoplastic diseases and improving immunity |
| CN103055214A (en) * | 2013-01-05 | 2013-04-24 | 马长林 | Traditional Chinese medicine for treating nasopharynx cancer by utilizing lepidogrammitis intermedia |
| CN103550719A (en) * | 2013-11-18 | 2014-02-05 | 梁轶聪 | Traditional Chinese medicinal composition for treating nasopharyngeal carcinoma |
Non-Patent Citations (4)
| Title |
|---|
| 姜苗等: "鼻咽癌的中西医结合诊治", 《中国临床医生》 * |
| 本草害利释义: "《本草害利释义》", 31 March 2012, 山西科学技术出版社 * |
| 杜志强: "晚期鼻咽癌验案1则", 《新中医》 * |
| 王德鉴主编: "《中医耳鼻咽喉口腔科学》", 31 January 1994, 人民卫生出版社 * |
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Application publication date: 20150527 |