CN107412397A - A kind of pharmaceutical composition for treating eye disease and preparation method thereof, preparation and application - Google Patents
A kind of pharmaceutical composition for treating eye disease and preparation method thereof, preparation and application Download PDFInfo
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Abstract
The invention discloses a kind of pharmaceutical composition for treating eye disease and preparation method thereof, preparation and application.The eyesight-improving tea 0.1~99% of the pharmaceutical composition of described treatment eye disease including raw material weight percentage, raspberry 0.1~99%, dispute over trifles 0.1~99%, be prepared through pre-treatment, extraction, post-processing step；Preparation is to add the auxiliary material pharmaceutically received in described pharmaceutical composition to be prepared into granule, tablet, capsule, soft capsule, mixture and Eye ointments etc.；Three kinds of prophylactic treatment cataract of old people, vitreous opacity and optic atrophy common eye diseases are being prepared using for described pharmaceutical composition.Pharmaceutical composition of the present invention has a special effect, Small side effects, no toxicity, can prevent, alleviate, treating eye disorders and have good therapeutic effect.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of pharmaceutical composition for treating eye disease and its preparation side
Method, preparation and application.
Background technology
The traditional Chinese medical science thinks that myopia belongs to the discussion category of " the remote diseases of the nearly Eradicates of energy ", and pathogenesis is insufficiency of the heart-yang, and God Light must not be sent out
More at a distance;Or liver and kidney deficiency, asthenia of essence and blood, so that ophthalmocopia, it is impossible to look far into the distance.The traditional Chinese medical science is divided to actual situation two big types illness in eye,
Real example is the most common with " cute conjunctivitis ", or because of wind-heat, or because of irascibility, preferably treated with dispelling wind and heat from the body or the patent medicine of clearing liver fire;Asthenic symptoms
It is then more to common are blurring of vision, cataract or glaucoma and yctalopia etc. caused by kidney deficiency and liver, preferably use the patent medicine to tonify the liver and kidney to treat.
Jin Daige floods exist《Handbook of Prescriptions for Emergencies》In recorded and dissipate (6 grams of Chinese gall, 9 grams of fructus viticis, grind face) plus water in copper pot with wind dispelling
Decoct, take liquid to rinse eyes, to treat foreign body sensation and itching in the eye pain.To the Tang Dynasty, eye therapy further develops, such as SUN Si miao《Qianjin Yi Fang》
Load washes eye side (cassia seed, radix polygonati officinalis, the bark of ash, the coptis, firefly) with Cassia, decocts drip flushing eyes, controls the misty no finding of eye.This
Outside, the Tang Dynasty Wang Tao《Medical secrets of official》, Song Dynasty《Peaceful holy benevolent prescriptions》, Ming Dynasty's Li Shizhen《Compendium of Materia Medica》, Qing Dynasty's Wu Shangxian
's《Li Yue Pianwen, Rhymed Discourse for Topical Remedies》Etc. the abundant content for describing a therapy, wherein《Peaceful holy benevolent prescriptions》In the 163 first smoked sides of washing recorded, it is used for
The prescription that eye is controlled is just first up to 24, and excellent basis has been laid for the development of eye therapy.
The eyes are the windows of the mind, and the eyes that everyone is intended to oneself are bright and limpid beautiful, however, with society development,
Living-pattern preservation is because the reason of weather, diet or daily life, people easily suffer from various eye part diseases, if too late
When treatment or malpractice, often changed into because of protracted course of disease chronic.However, the eye illness morbidity situation in China is but increasingly tight
It is high, and the trend that becomes younger is increasingly obvious.Threaten eyes disease no longer be mainly appeal, the disease related to age, metabolism
The incidence of disease rapidly increases, and new illness in eye blind rate is high, can not be ignored.New eye disease includes eyelid disease, lacrimal apparatus disease, conjunctiva
Disease, keratonosus, sclera disease, cataract, retinal disease, eye traumas, ocular tumor etc..Expert introduction, 80% cause
Blind property eye disease can be prevented can more, but treatment cycle is long, recurrence rate is higher, and treatment mostly is even more and cured the symptoms, not the disease, and after
It is serious to lose disease.More patients are more willing to select Traditional Chinese Medicine therapy, while yellow by some factors such as the elderly's ophthalmology disease picture
Spot denaturation, the increase of the diabetic retinopathy incidence of disease, ophthalmic remedy are just developing into a uniqueness for being full of competitive vigor
Market.
The content of the invention
The first object of the present invention is to provide a kind of pharmaceutical composition for treating eye disease；Second purpose is to provide
The preparation method of the pharmaceutical composition of described treatment eye disease；3rd purpose is to provide described treatment eye disease
The preparation of pharmaceutical composition；4th purpose is the application for providing the pharmaceutical composition of described treatment eye disease.
The first object of the present invention is achieved in that the pharmaceutical composition of described treatment eye disease includes raw material weight
Sparrow mouth tea 0.1 ~ 99%, raspberry 0.1 ~ 99% and the dried orange peel 0.1 ~ 99% of percentage are measured, through pre-treatment, extraction and post-processing step
It is prepared.
The second object of the present invention is achieved in that including pre-treatment, extraction and post-processing step, is specifically included：
A, pre-treatment：Weighed respectively by bulk drug composition and ratio, crushed the standby to material a of 20 ~ 100 mesh sieves mixing；
B, extract：The alcoholic extraction of concentration expressed in percentage by volume 30 ~ 70% that 8 ~ 12 times of material a weight is added in material a obtains extract solution
B, extract solution b is concentrated into relative density and obtains the liquid extract c of drug target composition for 1.01 ~ 1.07；
C, post-process：By the liquid extract of drug target composition through being dried to obtain the dry extract d of drug target composition.
The third object of the present invention, which is achieved in that in the pharmaceutical composition of described treatment eye disease, adds pharmacy
The auxiliary material of upper receiving is prepared into granule, powder, tablet, capsule, soft capsule, mixture, supensoid agent or Eye ointments.
The fourth object of the present invention is achieved in that the pharmaceutical composition of described treatment eye disease is being prepared in advance
Application in anti-/ treatment eye disease medicine.
Described eye disease is that the purport caused by the insufficiency of the spleen damp and hot, deficiency of liver-yin and kidney-yin is targetedly to improve cataract of old people
Also three kinds of cataract, vitreous opacity and optic atrophy common eye diseases are.
The pharmaceutical composition for the treatment of eye disease of the present invention has special effect, Small side effects, can treat old age
Cataract, vitreous opacity and optic atrophy illness, there is good therapeutic effect, no toxicity to above-mentioned illness.
Sparrow mouth tea in prescription of the present invention：Vaccinium dunalianum Wight.For Ericaceae blueberry platymiscium camphor tree
The drying herb of leaf blueberry.Camphor tree leaf blueberry nature and flavor：Micro-sweet, puckery, cool, return liver warp, kidney channel, large intestine road；Effect：Clearing heat and nourishing yin, dispel
Wind improving eyesight, relaxes bowel, relaxing tendons and activating collaterals.For vertigo, blurring of vision, product dyspepsia, arthralgia pain due to rheumatism.Yi nationality, distributed over Yunnan, Sichuan and Guizhou's use among the people
In：Hypopsia, weakness of the spleen and the stomach, indigestion, vertigo, blurring of vision, damp-heat accumulation, accumulation of food in the stomach and intes tine due to indigestion, mouth parched and tongue scorched, on
It is burnt damp and hot, drunk extensively in Central Yunnan as Yi nationality, distributed over Yunnan, Sichuan and Guizhou health protection tea among the people from ancient times, its soup look is orange bright, fragrant aroma, alcohol and
It is sweet.
Modern study shows that camphor tree leaf blueberry contains the phenolic substance of abundant antioxidation, such as flavonoids, anthocyan
With OPC class and caffeoyl ursin analog derivative etc., while also there is researcher to find that the tea also contains complete amino
Nutrient and manganese, iron, zinc, the selenium and other trace elements such as acid, crude fibre and Vc, and can obvious hyperkalemia hyponatremia feature.
Dried orange peel is rutaceae orange Citrus reticulate Blanco and its ripe pericarp of variety.It is different
Name orange peel《Sheng Nong's herbal classic》, orange peel《The southern regions of the Yunnan Province book on Chinese herbal medicine》, wide orange peel《Proper book on Chinese herbal medicine》.It is used as medicine and is preferred with old person.Acrid flavour,
Hardship, it is warm-natured.Returns spleen, stomach, lung channel.Function is with curing mainly：Regulating QI and lowering the adverseness, whet the appetite in tune, it is eliminating dampness and eliminating phlegm.Taste retention of dampness due to stagnation of QI is cured mainly,
Full vexed, the abdominal distention of chest diaphragm, do not feel like eating, vomits superinverse, difficulty in urination and defecation；Lung qi blocks, coughing with a lot of sputum.《Medical center, which is usurped, wants medicines
Property》：" on then purging the lung of pathogenic fire gas, lowering the adverse flow of qi；In then dry spleen it is wet, and middle gas；Under then relax edema with the liver involved, profit kidney life.It is main in pleasant, dissolving phlegm, go
It is strongly fragrant.”《Compendium of Materia Medica》：" orange peel, hardship can rush down can it is dry, it is pungent can dissipate, temperature can and.It controls all kinds of diseases and ailments, always takes the work(of its qi-regulating eliminating dampness,
Then mend with tonic, then rushed down with cathartic, then risen with hydrargyrum oxydatum crudum, then dropped with medicine is dropped.Spleen is the vigour wind-weed, and lung is to take the photograph wanting for gas, therefore orange peel
For two through qi leel will, but with match somebody with somebody and reinforcing and reducing methods lift.”《Daily book on Chinese herbal medicine》：" can dissipate to be rushed down, and energy temperature energy dried orange peel is mended, and can disappear diaphragm
Gas, resolving sputum saliva, and spleen are only coughed, and lead to five leaching.”
The main pharmacodynamics composition contained in dried orange peel is flavonoids（Dried orange peel glycosides, dried orange peel polymethoxyflavone, Nobiletin）, volatile oil
（Limonene）, alkaloids（Synephrine）.Aurantiamarin has the aldehyde reductase effect for suppressing rat crystalline lenses, and aurantiamarin can also
Strengthen toxic action of the adrenal gland to mouse, it is also possible to suppressing catechol-O-methyl transferase (COMT)（COMT）So as to reduce on kidney
Parathyrine destroys relevant.Aurantiamarin（Ⅰ）To diabetes rat renal function morphology influence caused by streptostacin, and and aminoguanidine（Ⅱ）
Contrasted.As a result aurantiamarin is shown（Ⅰ）The excretion of rat Urine proteins can be significantly reduced；Glomerular mesangial matrixes and basilar memebrane
Obvious mitigation is thickened, prompts I suppressing albumen non-glycosylation, prevention diabetogenous nephrosis complication has and aminoguanidine（Ⅱ）Tool
Play the role of similar.
Raspberry：Rubus chingii Hu.Different name covers basin《Bencao jizhu》, small pallet, Shan Pao《Chinese medicine handbook》.
Channel tropism：《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" enter liver, kidney two warp, sweet, sour, slightly warm in nature.With liver-kidney tonifying, astringent sperm contracting urine, improving eyesight.Cure mainly sun
Impotence premature ejaculation, emission and spermatorrhea, fertility is thin with, and frequent micturition, which is lost, drowns, visual dim, poliosis.《Kaibao Bencao》：" qi-restoratives
Continue absolutely, strong cloudy Jianyang, smoothing skin, peace and internal organs, middle benefit gas benefit power, treat wind void of straining, nourishing liver and improving eyesight."《Book on Chinese herbal medicine is stated》：" control labor
Tired, consumptive disease, liver kidney qi deficiency aversion to cold, kidney qi deficiency inverse cough, impotence, disappear illness, diarrhea, reddish and whitish turbid urine, and the arthroncus of knee is all to see blood trouble and mesh disease."
Also there is ancient books record《Shanghai collection proved recipe》Raspberry can control eye and secretly lose thing, and cold tears contamination is more than and glaucoma, day row mesh are dark：Western state
Grass, mesh is suddenly and violently dry, smashes and makes completely mashed, and thin silk floss wraps up in it, and with milk leaching, such as row eight or nine is inner uses long.In point mesh, that is, lie on the back.
Modern study shows that red raspberry contains organic acid, carbohydrate and a small amount of vitamin C, benzoaric acid (ellagic
Acid), cupreol (β-sitosterol), red raspberry acid (fupenzic acid).Except the warming kidney and enhancing yang of Traditional Chinese Medicine is consolidated
Essence effect is outer, still has anti-aging, anti-mutagenesis, promotes lymphopoiesis, reduces the multiple pharmacological effects such as serum cholesterol, with
Research is deepened continuously, and the exploratory development to the anticancer nootropic effect of raspberry will be brought more with confirmation for our life
Wide prospect.
In above-mentioned three medicine, sparrow mouth tea nature and flavor micro-sweet, puckery, cool, return liver warp, kidney channel, energy clearing heat and nourishing yin, dispelling pathogenic wind for improving eyesight, Yi nationality doctor
Weakness of the spleen and the stomach, damp-heat accumulation, it is monarch drug in a prescription for hypopsia.Dried orange peel bitter, pungent, temperature, returns spleen, stomach, lung channel.Energy regulating qi-flowing for strengthening spleen,
It is eliminating dampness and eliminating phlegm, it is ministerial drug.Raspberry is sweet, sour, temperature, energy supplementing the kidney to control the nocturnal, nourishing liver and improving eyesight, to the mesh screen cataract or glaucoma caused by deficiency and exhaustion of liver-YIN
Effectively, it is adjutant.Multiply insult theory from the five-element, raspberry makes wood not multiply soil, and water does not insult soil, makes to locate between liver, kidney, spleen
In relative balance state.We have invigorating the spleen to dry, dispelling pathogenic wind for improving eyesight.It is muddy for insufficiency of the spleen damp and hot caused brilliant pearl, it is dry and astringent dim-sighted,
Dry is not intended to drink；Cataract of old people, vitreous opacity, optic atrophy are shown in above-mentioned patient.
Brief description of the drawings
Fig. 1 is present invention process schematic flow sheet；
Fig. 2 is invention formulation process flow diagram.
Embodiment
With reference to embodiment and accompanying drawing, the present invention is further illustrated, but the present invention is not subject in any way
Limitation, based on present invention teach that any conversion or replacement made, belong to protection scope of the present invention.
Sparrow mouth tea 0.1 of the pharmaceutical composition including raw material weight percentage for the treatment of eye disease of the present invention ~
99%th, raspberry 0.1 ~ 99% and dried orange peel 0.1 ~ 99%, are prepared through pre-treatment, extraction and post-processing step.
The pharmaceutical composition of described treatment eye disease includes the sparrow mouth tea 50 ~ 75% of raw material weight percentage, raspberry
10 ~ 35% and dried orange peel 10 ~ 30%, it is prepared through pre-treatment, extraction and post-processing step.
Sparrow mouth tea 45.5. ~ 70.50% of the pharmaceutical composition including raw material weight percentage of described treatment eye disease,
Raspberry 14.82 ~ 33.60% and dried orange peel 11.90 ~ 28.36%, are prepared through pre-treatment, extraction and post-processing step.
The preparation method of the pharmaceutical composition for the treatment of eye disease of the present invention, including pre-treatment, extraction and rear place
Step is managed, is specifically included：
A, pre-treatment：Weighed respectively by bulk drug composition and ratio, crushed the standby to material a of 20 ~ 100 mesh sieves mixing；
B, extract：The alcoholic extraction of concentration expressed in percentage by volume 30 ~ 70% that 8 ~ 12 times of material a weight is added in material a obtains extract solution
B, extract solution b is concentrated into relative density and obtains the liquid extract c of drug target composition for 1.01 ~ 1.07；
C, post-process：By the liquid extract of drug target composition through being dried to obtain the dry extract d of drug target composition.
Also include clarification steps in step B, it is specifically that the volume basis that 8 ~ 12 times of material a weight is added in material a is dense
30 ~ 70% alcoholic extractions of degree obtain extract solution b, and extract solution b is concentrated into relative density obtains drug target group for 1.01 ~ 1.07
The liquid extract c first products of compound, the fining agent for adding liquid extract c first products percetage by weight 0.15 ~ 0.25 ‰ are clarified, specially 25 ~
35 DEG C of 0.5 ~ 1.5h of insulation, then 10 DEG C once stand 8 ~ 24h, take supernatant liquid filtering, filtrate decompression is concentrated to give drug target
The liquid extract c of composition.
Described fining agent is diatomite or chitosan.
It is extracted as seepage pressure effects, refluxing extraction described in step B, decocts extraction, Microwave Extraction, ultrasonic extraction, cold soaking
Extraction or temperature extraction take.
The dry extract d of drug target composition described in step C moisture content is 5 ~ 7%.
The present invention specifically prepares liquid extract and the method for dry extract is as follows：
First, for treating the liquid extract preparation method of eye disease
Percolation extracts
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, crushed as coarse powder, the 8-12 times of 30-70% measured of addition wine
Essence, the effective component extracting with 1-3ml/kg speed collection percolate；Collect percolate and be concentrated into solid-liquid ratio as 1：6, use
0.03-0.06 ‰ fining agent diatomite clarification, 40-60 DEG C of insulation 20-60min, in less than 10 DEG C left undisturbed overnights, filtering, adds
Enter preservative and obtain liquid extract.
Circumfluence method is extracted
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, crushed as coarse powder, the 8-12 times of 30-70% measured of addition wine
Essence immersion 2-4h, water is supplied before backflow by water absorption rate, and flow back 1-2h for the first time, second, third time respectively plus 8 times of amount alcohol return
0.5-1h is flowed, filtration, merges filtrate three times, is concentrated into solid-liquid ratio as 1：6, clarified with 0.03-0.06 ‰ fining agent diatomite,
40-60 DEG C of insulation 20-60min, in less than 10 DEG C left undisturbed overnights, filtering, add preservative and obtain liquid extract.
Decocting method extracts
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, crushed as coarse powder, the 8-12 times of 30-70% measured of addition wine
Essence soaks 2-4h, and decoction is preceding to supply water by water absorption rate, decocts 1-2h for the first time, respectively adds 8 times of amount alcohol to decoct for the second time, for the third time
0.5-1h is boiled, is filtered, merges filtrate three times, is concentrated into solid-liquid ratio as 1：6, clarified with 0.03-0.06 ‰ fining agent diatomite,
40-60 DEG C of insulation 20-60min, in less than 10 DEG C left undisturbed overnights, filtering, add preservative and obtain liquid extract.
Ultrasonic wave extraction
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, crushed as coarse powder, the 8-12 times of 30-70% measured of addition wine
Essence immersion 2-4h, supplies water before ultrasonic extraction, for the first time ultrasonic 10-40min by water absorption rate, second, third time respectively plus 8 times
Alcohol 50HZ ultrasound 0.5h are measured, filtration, merge filtrate three times, are concentrated into solid-liquid ratio as 1：6, with 0.03-0.06 ‰ fining agent
Diatomite is clarified, and 40-60 DEG C of insulation 20-60min, in less than 10 DEG C left undisturbed overnights, filtering, is added preservative and is obtained liquid extract.
2nd, for improving, treating the dry extract preparation method of eye disease
Percolation extracts
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, infiltrate 2-4h with 8-12 times of 30-70% alcohol；With oozing
Method of filtering is extracted, and percolate is collected with the speed of 1-3ml per kilogram inventorys, is concentrated into relative density and is filtered for 1.01-1.07, is added
Enter 0.03-0.06 ‰ chitosan, stir evenly.More than 24 hours are stood, Aspirate supernatant filtering, filtrate decompression is concentrated to give stream leaching
Cream, continue to be condensed into dry extract.
Circumfluence method is extracted
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, infiltrate 2-4h with 8-12 times of 30-70% alcohol；Backflow
Preceding to supply water by water absorption rate, backflow 1-2h, respectively adds 8 times of amount reflow of alcohol 0.5-1h, filters for the second time, for the third time for the first time,
Merge filtrate three times, be concentrated into relative density and filtered for 1.01-1.07, add 0.03-0.06 ‰ chitosan, stir evenly.Stand
More than 24 hours, Aspirate supernatant filtering, filtrate decompression was concentrated to give liquid extract, continues to be condensed into dry extract.
Decocting method extracts
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, infiltrate 2-4h with 8-12 times of 30-70% alcohol；Decoct
It is preceding to supply water by water absorption rate, 1-2h is decocted for the first time, is respectively added 8 times of amount alcohol to decoct 0.5-1h for the second time, for the third time, is filtered,
Merge filtrate three times, be concentrated into relative density and filtered for 1.01-1.07, add 0.03-0.06 ‰ chitosan, stir evenly.Stand
More than 24 hours, Aspirate supernatant filtering, filtrate decompression was concentrated to give liquid extract, continues to be condensed into dry extract.
Ultrasonic wave extraction
Sparrow mouth tea, raspberry, the taste pharmaceutical decocting piece of dried orange peel three are cleaned, infiltrate 2-4h with 8-12 times of 30-70% alcohol；Ultrasound
Water is supplied by water absorption rate before extracting, for the first time ultrasonic 10-40min, respectively adds 8 times of amount alcohol ultrasound 0.5h for the second time, for the third time,
Filtration, merge filtrate three times, be concentrated into relative density and filtered for 1.01-1.07, add 0.03-0.06 ‰ chitosan, stir evenly.
More than 24 hours are stood, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, continues to be condensed into dry extract.
It is of the present invention be used to improving, treat can be added in the pharmaceutical composition of eye disease medicinal fining agent, excipient,
Solvent, preservative, PH conditioning agents, isotonic regulator.
Fining agent：101 fruit juice clarifiers：Production unit：Zhengzhou Tian Shuan Year food additives Co., Ltd；Gelatin：Production is single
Position：Dongguan City is newly into gelatin Co., Ltd；Chitosan, production unit：Qingdao latent light bioengineering Co., Ltd；Diatomite：Cloud
Nan Sheng Tengchong Counties filter aid factory；Preservative：Sodium benzoate, parabens；
Excipient：Gelatin, glycerine, dextrin, starch, silica, magnesium stearate, microcrystalline cellulose, sodium carboxymethylcellulose, second
Base cellulose, hydroxypropyl cellulose, polyethylene glycol, polyvinylpyrrolidone, Tween-80.
Solvent：Vegetable oil（Eucalyptus oil, peanut oil, rapeseed oil, walnut oil）, glycerine, propane diols, atoleine, beeswax；
Purified water.
Excipient：Gelatin, glycerine, dextrin, starch, silica, magnesium stearate, microcrystalline cellulose, carboxymethyl cellulose
Sodium, ethyl cellulose, hydroxypropyl cellulose, activated carbon, beeswax, polyethylene glycol, polyvinylpyrrolidone, tween -80.
Preservative：Salicylic acid, benzoic acid and sodium benzoate, methyl p-hydroxybenzoate, ethyl ester, propyl ester, butyl ester（Nipalgin
Class）, eucalyptus oil.
Flavouring：Honey, stevioside glycosides, saccharin sodium.
Isotonic regulator：Sodium chloride, glucose.
The fining agent of addition, excipient, solvent, preservative, the quantity of PH conditioning agents are carried out by medicinal standard requirement above.
The preparation of pharmaceutical composition of the present invention is to add the auxiliary material pharmaceutically received in described pharmaceutical composition
It is prepared into granule, powder, tablet, capsule, soft capsule, mixture, supensoid agent or Eye ointments.
It is described be used to treat the preparation method of eye disease granule be：Medicine dry extract is crushed, crosses 80-100 mesh sieves,
It is with auxiliary materials and mixing, granulation, drying, whole grain, packing such as starch, dextrin, superfine silica gel powder, carboxymethyl cellulose-Na, magnesium stearates
.
It is described be used to treat the preparation method of eye disease powder be：By the liquid extract of medicine extraction gained, bigcatkin willow is added
Acid, boric acid, zinc oxide, starch etc., sterilizing, thus obtaining the product.
It is described be used to treat the preparation method of eye disease tablet be：Each supplementary material for being formulated dosage is weighed, mixed, system
Grain, dry, tabletting produce；The preparation method for eye disease Film coated tablets or Enteric coated tablets is：By medicine dry extract
Crush, cross 80 mesh sieves, with starch, microcrystalline cellulose, magnesium stearate mixing, granulation, dry, tabletted, film coating or intestines
Molten clothing produces.
It is described be used to treat the preparation method of eye disease capsule be：Medicine dry extract is crushed, crosses 80-100 sieves, with
Silica, magnesium stearate, microcrystalline cellulose, ethyl cellulose mix, and granulation, whole grain, are packed into hard shell capsules or capsulae enterosolubilis
Inside produce.Medicine preparation, medicine dry extract is crushed, cross 200 mesh sieves, pelletized, dried with hydroxypropyl cellulose, whole grain, by capsule
Grain is placed in seed-coating machine, and micro-capsule is made in the ethanol solution for adding polyethylene glycol and ethyl cellulose, is packed into hard shell capsules or compacting
In flakes, produce.
It is described be used to treat the preparation method of eye disease soft capsule be：Medicine dry extract is crushed, crosses 200 mesh sieves,
With the auxiliary materials and mixing such as polyethylene glycol, gelatin, glycerine, water, soft capsule is made and produces；The preparation side for eye disease dripping pill
Method is：Medicine dry extract is crushed, crosses 200 mesh sieves, with the auxiliary materials and mixing such as polyethylene glycol, glycerine, dripping pill is made and produces.
It is described to be used to treat eye disease mixture（Oral liquid）Preparation technology be：By medicine liquid extract add purified water,
Dissolve by heating, addition honey, activated carbon boil, and filter, refrigerate while hot, filtering, and filtrate adds citric acid, addition purified water adjustment
To amount of preparation, packing, sterilizing, produce.
It is described be used to treat the preparation technology of eye disease eye drops be：Medicine liquid extract is added into purified water, heating is molten
Solution, activated carbon is added, boils, filter, filtrate refrigeration, Aspirate supernatant filtering, filtrate addition sodium chloride regulation is isotonic, adds phosphorus
Acid dihydride sodium and disodium hydrogen phosphate regulation pH value, add ethylparaben, add purified water and adjust to amount of preparation, dispense, i.e.,
.
For treating the purposes of eye disease drug regimen：The drug regimen is characterized in that senile white interior for treating
The eye class illness such as barrier, vitreous opacity, chronic retrobulbar neuritis.In terms of tcm syndrome including：It is insufficiency of the spleen damp and hot, damp and hot to accumulate
Knot, wet turbid general, deficiency of liver-yin and kidney-yin etc..
The drug regimen formula of present invention treatment eye disease has special effect, and Small side effects, no toxicity can be pre-
Prevent, treat a variety of eye diseases, there is good therapeutic effect.
The application of pharmaceutical composition of the present invention is that described pharmaceutical composition is preparing alleviation, treating a variety of eyes
Application in disease medicament.
The preparation of the pharmaceutical composition for the treatment of eye disease of the present invention is the described medicine for treating eye disease
The auxiliary material pharmaceutically received is added in composition and is prepared into granule, powder, tablet, capsule, soft capsule, mixture, suspension
Agent or Eye ointments.
The application of the pharmaceutical composition for the treatment of eye disease of the present invention is the described medicine for treating eye disease
Application of the composition in preventing/treating eye disease medicine is prepared.
So that case is embodied, the present invention will be further described below：
Embodiment 1
Sparrow mouth tea 150g, raspberry 50g, dried orange peel 60g, the three common 260g of taste pharmaceutical decocting piece are weighed, are crushed as coarse powder, mixing.First
Secondary plus 10 times of amounts 70% ethanol soaks 2h, and amount of alcohol is supplied by water absorption rate before backflow, and flow back 2h for the first time, and second and third time respectively adds
8 times of amount backflow 1h, filtration, merge filtrate three times, are concentrated into relative density as 1.05.It is clear to add the chitosan that dosage is 0.2 ‰
Clearly, 30 DEG C of insulation 1h, less than 10 DEG C standing more than 8h, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, dry to do
Medicinal extract.
Embodiment 2
Sparrow mouth tea 450g, raspberry 150g, dried orange peel 180g, the three common 780g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.For the first time
Add the ethanol of 12 times of amounts 50% to soak 4h, amount of alcohol is supplied by water absorption rate before backflow, flow back 1.5h for the first time, and second and third time respectively adds
9 times of amount backflow 1h, filtration, merge filtrate three times, are concentrated into relative density as 1.10.It is clear to add the diatomite that dosage is 0.3%
Clearly, 50 DEG C of insulation 1h, less than 10 DEG C standing more than 12h, Aspirate supernatant filter, and filtrate decompression is concentrated to give liquid extract, dry
Dry extract.
Embodiment 3
Sparrow mouth tea 900g, raspberry 300g, dried orange peel 360g, the three common 1560g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.For the first time
Add the ethanol immersion 1h of 10 times of amounts 70%, container is put into ultrasonic washing instrument, ultrasonic extraction 30min, stood after stirring 1 time
30min, again ultrasonic extraction 30min, stood after stirring 1 time, so repeatedly after ultrasonic extraction 3 times, filtration, merging is filtered three times
Liquid, relative density is concentrated into as 1.05.Add the chitosan that dosage is 0.3 ‰ to clarify, 30 DEG C of insulations 1h, less than 10 DEG C standing 8h
More than, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, dry dry extract.
Embodiment 4
Sparrow mouth tea 150g, raspberry 50g, dried orange peel 60g, the three common 260g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.Add for the first time
The ethanol immersion 2h of 12 times of amounts 30%, container is put into ultrasonic washing instrument, ultrasonic extraction 35min, stood after stirring 1 time
30min, again ultrasonic extraction 20min, stood after stirring 1 time, so repeatedly after ultrasonic extraction 3 times, filtration, merging is filtered three times
Liquid, merge filtrate three times, be concentrated into relative density as 1.10.Add dosage be 0.4% diatomite clarify, 40 DEG C insulation 1h, 10
More than 12h, Aspirate supernatant filtering are stood below DEG C, filtrate decompression is concentrated to give liquid extract, dry dry extract.
Embodiment 5
Sparrow mouth tea 900g, raspberry 300g, dried orange peel 360g, the three common 1560g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.Add by several times
The ethanol immersion 6h of 10 times of amounts 70%, the medicinal material infiltrated is put into diacolation bucket and flattened, is covered above with filter paper, cold soaking 96h,
Piston is opened, starts to collect percolate with 1ml/min at a slow speed, is concentrated into relative density as 1.05.Add the shell that dosage is 0.4 ‰
Glycan is clarified, and 40 DEG C of insulation 1h, less than 10 DEG C standing more than 8h, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, dry
It is dry to obtain dry extract.
Embodiment 6
Sparrow mouth tea 450g, raspberry 150g, dried orange peel 180g, the three common 780g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.Add by several times
The ethanol immersion 6h of 12 times of amounts 50%, the medicinal material infiltrated is put into diacolation bucket and flattened, is covered above with filter paper, cold soaking 72h,
Piston is opened, starts to collect percolate with 2ml/min at a slow speed, is concentrated into relative density as 1.10.Add the silicon that dosage is 0.5%
Diatomaceous earth is clarified, and 50 DEG C of insulation 1h, less than 10 DEG C stand more than 12h, Aspirate supernatant filtering, and filtrate decompression is concentrated to give liquid extract,
Dry dry extract.
Embodiment 7
Sparrow mouth tea 4.5g, raspberry 1.5g, dried orange peel 1.8g, the three common 7.8g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.Add by several times
The ethanol immersion 6h of 10 times of amounts 70%, the medicinal material infiltrated is put into diacolation bucket and flattened, is covered above with filter paper, cold soaking 96h,
Piston is opened, starts to collect percolate with 1ml/min at a slow speed, is concentrated into relative density as 1.18.It is sterile to add 5 times of amounts
Water, stir evenly, stand more than 24h, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, dry dry extract.
Embodiment 8
Sparrow mouth tea 450g, raspberry 150g, dried orange peel 180g, the three common 780g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.Add by several times
The ethanol immersion 6h of 12 times of amounts 50%, the medicinal material infiltrated is put into diacolation bucket and flattened, is covered above with filter paper, cold soaking 72h,
Piston is opened, starts to collect percolate with 2ml/min at a slow speed, is concentrated into relative density as 1.26.2 times of amount sterilized waters are added, are stirred
It is even, more than 24h, Aspirate supernatant filtering are stood, filtrate decompression is concentrated to give liquid extract, dry dry extract.
Embodiment 9
Sparrow mouth tea 900g, raspberry 300g, dried orange peel 360g, the three common 1560g of taste pharmaceutical decocting piece, crush as coarse powder, mixing.Add by several times
The ethanol immersion 6h of 10 times of amounts 70%, the medicinal material infiltrated is put into diacolation bucket and flattened, is covered above with filter paper, cold soaking 96h,
Piston is opened, starts to collect percolate with 1ml/min at a slow speed, is concentrated into relative density as 1.18.It is sterile to add 5 times of amounts
Water, stir evenly, stand more than 24h, Aspirate supernatant filtering, filtrate decompression is concentrated to give liquid extract, dry dry extract.
Embodiment 10
The embodiment for treating the granule of ocular disease drug combination
Embodiment 11
The embodiment for treating the tablet of ocular disease drug combination
Embodiment 12
The embodiment for treating the capsule of ocular disease drug combination
Embodiment 13
The embodiment for treating the soft capsule of ocular disease drug combination
Embodiment 14
Choose the therapeutic effect that 54 Aged-related Cataract Patients observe medicine.Treatment group takes embodiment 3 and is prepared
Pharmaceutical composition, 6g/ times, 3 times a day；Water is taken in control.After uninterruptedly taking 20d, the vision condition of follow-up patient, brilliant pearl
Muddiness is reduced, and is bleached substantially without sensation of dryness, tongue fur by yellow greasy；The comparison sheet of two groups of patient clinical curative effects is as follows：
Embodiment 15
Certain male, 63 years old, make a definite diagnosis vitreous opacity 3 years, during one's sickness intermittent treatment mistake, but it is ineffective.Persistently take this hair
After the pharmaceutical composition 45d that bright embodiment 3 is prepared, with the elegant sense of winged shadow of the mosquito, fly, starlet of presensation at the moment
Significantly reduce, mitigation uncomfortable in chest, no vexed sense of bitter taste.This user is fine to drug evaluation provided by the invention.Tested more than
Understand：Medicine provided by the invention has remarkable result to improving, treating vitreous opacity.
Embodiment 16
Certain male, 43 years old, hence it is evident that feel that visual impairment had more than 2 years, be diagnosed as optic atrophy.Constantly take the embodiment of the present invention
After the 3 pharmaceutical composition 60d being prepared, blurring of vision sense mitigates, this disappearance of sensillary base that eye is swollen, and intraocular pressure reduces, and there is expansion in the visual field
Sense.This user is very good to drug evaluation provided by the invention.Tested more than：Medicine provided by the invention is to changing
Kind, treatment optic atrophy has remarkable result, and improving glaucoma type illness in eye to future has certain market prospects.
Embodiment 17
Respectively with embodiment 1, embodiment 2, embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8, embodiment 9, reality
Example 10, embodiment 11, embodiment 12, embodiment 13 is applied to be tested, the results showed that, the pharmaceutical composition that the present invention is prepared
Pharmaceutical composition prevention, treatment eye disease to eye disease disease have better effects, there is huge market prospects.
Claims (10)
- A kind of 1. pharmaceutical composition for treating eye disease, it is characterised in that the pharmaceutical composition bag of described treatment eye disease Include sparrow mouth tea 0.1 ~ 99%, raspberry 0.1 ~ 99% and the dried orange peel 0.1 ~ 99% of raw material weight percentage, through pre-treatment, extraction and after Processing step is prepared.
- 2. the pharmaceutical composition for the treatment of eye disease according to claim 1, it is characterised in that described treatment eye disease The pharmaceutical composition of disease includes sparrow mouth tea 50 ~ 75%, raspberry 10 ~ 35% and the dried orange peel 10 ~ 30% of raw material weight percentage, before menstruation Processing, extraction and post-processing step are prepared.
- 3. the pharmaceutical composition for the treatment of eye disease according to claim 1, it is characterised in that described treatment eye disease The pharmaceutical composition of disease includes sparrow mouth tea 45.5. ~ 70.50%, raspberry 14.82 ~ 33.60% and the dried orange peel of raw material weight percentage 11.90 ~ 28.36%, it is prepared through pre-treatment, extraction and post-processing step.
- A kind of 4. preparation method of the pharmaceutical composition of any described treatment eye disease of claim 1 ~ 3, it is characterised in that Including pre-treatment, extraction and post-processing step, specifically include：A, pre-treatment：Weighed respectively by bulk drug composition and ratio, crushed the standby to material a of 20 ~ 100 mesh sieves mixing；B, extract：The alcoholic extraction of concentration expressed in percentage by volume 30 ~ 70% that 8 ~ 12 times of material a weight is added in material a obtains extract solution B, extract solution b is concentrated into relative density and obtains the liquid extract c of drug target composition for 1.01 ~ 1.07；C, post-process：By the liquid extract of drug target composition through being dried to obtain the dry extract d of drug target composition.
- 5. preparation method according to claim 4, it is characterised in that also include clarification steps in step B, specifically by thing The alcoholic extraction of concentration expressed in percentage by volume 30 ~ 70% that 8 ~ 12 times of material a weight is added in material a obtains extract solution b, and extract solution b is concentrated The liquid extract c first products of drug target composition are obtained for 1.01 ~ 1.07 to relative density, add liquid extract c first product weight percents The fining agent clarification of number 0.15 ~ 0.25 ‰, specially 25 ~ 35 DEG C 0.5 ~ 1.5h of insulation, then 10 DEG C once stand 8 ~ 24h, take Supernatant liquid filtering, filtrate decompression are concentrated to give the liquid extract c of drug target composition.
- 6. preparation method according to claim 5, it is characterised in that described fining agent is diatomite or chitosan.
- 7. preparation method according to claim 4, it is characterised in that be extracted as seepage pressure effects, backflow described in step B Extraction, decoction extraction, Microwave Extraction, ultrasonic extraction, cold soaking extraction or temperature extraction take.
- 8. preparation method according to claim 4, it is characterised in that the dry leaching of the drug target composition described in step C Cream d moisture content is 5 ~ 7%.
- 9. the preparation of the pharmaceutical composition of any described treatment eye disease of a kind of claim 1 ~ 3, it is characterised in that described Treatment eye disease pharmaceutical composition in add the auxiliary material pharmaceutically received and be prepared into granule, powder, tablet, capsule Agent, soft capsule, mixture, supensoid agent or Eye ointments.
- 10. the application of the pharmaceutical composition of any described treatment eye disease of a kind of claim 1 ~ 3, it is characterised in that described Treatment eye disease application of the pharmaceutical composition in preventing/treating eye disease medicine is prepared.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524394A (en) * | 2008-10-08 | 2009-09-09 | 云南天秀植物科技开发有限公司 | Quezui tea preparation and application thereof |
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- 2017-05-18 CN CN201710356371.7A patent/CN107412397A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101524394A (en) * | 2008-10-08 | 2009-09-09 | 云南天秀植物科技开发有限公司 | Quezui tea preparation and application thereof |
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Application publication date: 20171201 |