CN102764324A - Medicine composition for treating neoplastic diseases and improving immunity - Google Patents
Medicine composition for treating neoplastic diseases and improving immunity Download PDFInfo
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- CN102764324A CN102764324A CN2012102624180A CN201210262418A CN102764324A CN 102764324 A CN102764324 A CN 102764324A CN 2012102624180 A CN2012102624180 A CN 2012102624180A CN 201210262418 A CN201210262418 A CN 201210262418A CN 102764324 A CN102764324 A CN 102764324A
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Abstract
The invention relates to the technical field of medicine, in particular to a medicine composition for treating neoplastic diseases and improving immunity. The medicine composition comprises 35-60% of mistletoe, 8-15% of astragalus, 8-15% of radix scutellariae, 8-15% of coptis root, 8-20% of Cape jasmine and 5-8% of dandelion. The composition has anticancer and immunotherapy functions, and can achieve the effects of resisting cancer, improving immunity and preventing diseases.
Description
Technical field:
The present invention relates to medical technical field, exactly is a kind of tumor disease and pharmaceutical composition that improves immunity of treating.
Background technology:
Malignant tumor (Tumor) be body under various carcinogenic factor effects, some cells of local organization lose the normal regulation to its growth on gene level, cause its clonal abnormality hypertrophy and the neoplasm that forms.Educational circles generally is divided into optimum and pernicious two big types with tumor.At present the method for treatment tumor mainly contains following several kinds, and 1, excision: relatively be fit to early discovery and the reasonable patient of health: 2, chemotherapy: drug side effect is bigger; 3, radiotherapy: side effect is also bigger; The targeted drug treatment: very expensive, majority do not afford to do; Chinese and western medicine medicine combined treatment, Chinese and western medicine medicine curative effect is remarkable inadequately at present.
Summary of the invention:
The object of the invention just provides a kind of more efficiently antitumor that can be used for, the medicine of immunization therapy and enhancing immunity---a kind of pharmaceutical composition of treating tumor disease and raising immunity, and its preparation method is provided.
The present invention selects Herba Visci, the Radix Astragali, and Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Herba Taraxaci makes up, and makes each efficacy of drugs produce synergism these drug regimens then, thereby can play antitumor, the effect of immunization therapy and immunostimulant.
Herba Visci contains coagulation bundle (lectin), viscotoxin, polysaccharide; Kind of composition surplus the alkaid, oleanolidacid etc. 1700, but coagulation bundle kill harmful cell wherein; Promote secretion, viscusin can downright badly be harmful to cell when high dose, improves the effect of immunity during low dosage; Antitumor action is arranged, the immunocompetence of polysaccharide enhanced NK cell and LAK cell, forceful action is in the propagation of T cell.
In order to increase drug effect, reduce side effect, the present invention adds the Radix Astragali, Radix Scutellariae, Rhizoma Coptidis, Fructus Gardeniae, Herba Taraxaci makes up.This is because of the Radix Astragali, ability yang invigorating warm in nature, slightly sweet flavor.Have effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, detoxification evacuation of pus, granulation promoting.Rhizoma Coptidis, meridian distribution of property and flavor, (root) hardship, cold, nontoxic.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.The ability heat clearing and damp drying, eliminating fire and detoxication.Radix Scutellariae contains baicalin, baicalin, antipathogen, antiinflammatory, adjusting immunologic function, analgesic, calm, protect the liver, choleretic effect.Fructus Gardeniae, GUIXIN liver lung stomach tri-jiao channel.Have effects such as hepatoprotective function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence.Herba Taraxaci contains multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin, and effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting are arranged.Have better curative effect and need test repeatedly just can obtain and how it is arranged in pairs or groups.The concrete prescription as follows: contain Herba Visci 35-60 ﹪ in the medicine; The Radix Astragali 8-15 ﹪; , Radix Scutellariae 8-15 ﹪, Rhizoma Coptidis 8-15 ﹪, Fructus Gardeniae 8-20 ﹪; The ratio of Herba Visci and distilled water is 1-1.5:5-7 in the prescription.More than be weight ratio.
Processing technology is following:
1, gathers the Herba Visci that contains cohesion bundle (viscotoxin, polysaccharide, alkaioid, oleanolic acid) in stage in February October to next year;
2, in flowing water, clean Herba Visci;
3, cut into slices behind the removal moisture;
Mix Herba Visci and distilled water, the mixing ratio of Herba Visci and distilled water is 1-1.5:5-7, contains Herba Visci 35-60 ﹪ in the medicine; The Radix Astragali 8-15 ﹪; , Radix Scutellariae 8-15 ﹪, Rhizoma Coptidis 8-15 ﹪, Fructus Gardeniae 8-20 ﹪;
4,60-120 ℃ was heated distillation extraction 2 hours; Extracting solution is put into filter; The specification of microporous filter membrane is 0.1-0.4um;
5, extracting solution is put into glass medicine bottle;
6, sterilization after the medicine bottle vacuum compression, 20 minutes sterilizations between 120 ℃ to 130 ℃;
Also can add Herba Taraxaci 5-8 ﹪ in the above medicine.Extract extracts filtration under the nanometer state, regulated pH value 7.35-7.42 when extracting simultaneously.
The beneficial effect of the invention is: the present invention filters with filter after Herba Visci and the additive distillation extraction, vacuum sterilization, forms anticancer, the immunotherapy medicaments thing, can produce anticancer, raising immunity and prophylactic effect.Pharmaceutical compositions of the present invention is a natural plants, and human body is had no side effect, and is free of a burden, but life-time service.
The specific embodiment
:
ImplementExample 1:
(1) Herba Visci (formal name used at school: VISCUM ALBUM, contain composition: Lectin, Viscotoxin, Polysacchaide; Alkaioid, Oleanolic acid, other are kind surplus 1700) gather be February-October next year, in flowing water, clean; Herba Visci 150 grams, Rhizoma Coptidis 35 grams, Radix Scutellariae 20 grams, the Radix Astragali 30 grams; Fructus Gardeniae 25 grams after Herba Taraxaci 15 grams are cleaned, are removed moisture, section.
Cut into slices after removing moisture.
(2) Herba Visci mixes with distilled water, and mixing ratio is 1-1.5:5-7, and mixed proportion is 1:5 for well, surpasses or concentration change can take place when not enough, and concentration is low excessively, influences drug effect, excessive concentration, and slight side effect such as cause vomiting;
(3) pack mixture in the container into, heating when at this moment too high or too low for temperature, can not fully be extracted the effective ingredient of Herba Visci in 60 ℃ to 110 ℃, optimum temperature be 80 ℃ for well;
(4) the vial of dress extract high temperature sterilize in Celsius 120 spend-130 ℃;
(5) liquid that extracts filters in filter, and the specification of microporous filter membrane is 0.1-0.4um, vacuum compression sealing back sterilization in the vial of the sterilization of packing into;
(6) through clinical experiment, extract has antitumaous effect, reduces the side effect of the chemotherapy in anticancer, and the raising immunologic function has therapeutical effect to various dermatosiss simultaneously.
Embodiment 2:(1) Herba Visci 100 grams, Rhizoma Coptidis 25 grams, Radix Scutellariae 25 grams, the Radix Astragali 25 grams, Fructus Gardeniae 25 grams after Herba Taraxaci 15 grams are cleaned, are removed moisture, section.
(2) Rhizoma Coptidis: herbaceos perennial, belong to the Ranunculaceae Coptis, contain berberrine, worene, other polnitine co-ptisine
(3) Radix Scutellariae: be labiate, contain baicalin, baicalin, antipathogen, antiinflammatory, adjusting immunologic function, analgesic, calm, protect the liver, choleretic effect.
(4) Radix Astragali, ability yang invigorating warm in nature, slightly sweet flavor.Have invigorating QI to consolidate the body surface resistance, diuretic detumescent, detoxification evacuation of pus,
Effects such as granulation promoting.
(5) Fructus Gardeniae: Maguireothamnus speciosus, contain flavonoid gardenin (Gardenin), triterpenoid compound crocin (Crocin), crocetin (Crocetin) and α-Stigma Croci glycoside unit (α-Crocetin); Also contain iridoid glycosides gardenoside (Jasminoidin), gardenoside (Gardenoside), geniposide (geniposide, Geniposide), genipin gentiobioside (Genipingentiobioside), shanzhiside (Shan-zhiside), Fructus Gardeniae ketone glycoside (Gardoside), Herba Paederiae time glycoside methyl ester (Scandoside methyl ester), take off acetyl rubichloric acid. acid methyl ester (Deacetylasperulosidic acid methyl ester), geniposidic acid (Geniposidic acid) etc. in addition, still contain D-mannitol (D-mannitol), cupreol (β-sitosterol), nonacosane (Nonacosane), ursolic acid (Ursolic acid).
(6) Herba Taraxaci: Dandelion Compositae herbaceos perennial.Head inflorescence, the bobbles that the adularescent pappus is formed on the seed, new life is bred in the new place that racks after the flowers are in blossom.Contain multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in the Herba Taraxaci plant, effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting are arranged.Herba Taraxaci contains protein, fat, carbohydrate, trace element and vitamin etc. simultaneously, and abundant nutritive value is arranged, and is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Technology is with embodiment 1.
Other 3-4 embodiment drug ratios see the following form:
The clinical experiment result,
Extract is to improving immunity, and skin allergy is prevented apoplexy, and the patient's that has a high fever treatment has effect significantly.
The foregoing description 1, among the embodiment 2, extract extracts filtration under the nanometer state, regulated pH value 7.35-7.45 when extracting simultaneously, can be used for intravenous injection, and subcutaneous injection or external can be used safely.
More than explanation only illustrates basic thought of the present invention, in technical scope of the present invention, has the people of corresponding knowledge correspondingly to change.The present invention belongs to low cytotoxic drug through toxicity test, and life-time service also can.
Range of application: the present invention can be used for anticancer, extensive use in the making field of the constituent of immunization therapy.
Usage: subcutaneous, or intramuscular injection 0.5-1.0 milliliter, day is once.
Comprise various compositions such as lectin, enhancing human body immunity power, performance antitumaous effect; Be that it is the activate immunity function, improve anticancer power, optionally attack cancerous cell; The growth of anticancer; Be summarized in short, can activate immunocytes such as natural killer cell, phagocyte, dendritic cell, T cell, secretion cytokin performance
1: activate natural killer cell, secretion peoporin granule is eliminated cancerous cell at the cancer initial stage.
2: activate phagocyte, kill cancerous cell, send cancerous cell information to helper T cell simultaneously.
3: activated phagocyte secretion interlukin-1, TNF-α, interlukin-12 etc. destroy tumor factor cytokin, simultaneously activate immunity commander in chief helper T cell.
4: activate dendritic cell, gulp down cancerous cell, and cancerous cell information is passed to helper T cell.
5: the helper T cell secretion interlukin-2 that receives information, activate killer T cell, B cell.
6: auxiliary (Th0) T cell is accepted the information that phagocyte passes to and is secreted interlukin-12 later on, activates the killerT cell.
7: the killerT emiocytosis peoporin granule that is activated, penetrate cancer cell membrane, attack cancerous cell, destruction of cancer cells.
Pharmacological action
1, transfer and the growth to the perioperatively cancerous cell of various cancers has inhibitory action.
2, the side effect after minimizing anticarcinogen and the radiotherapy promotes to recover.
3, inoperable advanced carcinoma patient after receiving treatment, palliates the agonizing sufferings, and improves the nature therapeutic effect, prolongs life, improves the quality of living.
4, high dose therapy is directly thrown medicine into cancerous cell or lymphoid tissue, and downright bad cancerous cell palliates the agonizing sufferings, the quick growth of anticancer.
5, after the advanced carcinoma patient received treatment, body temperature rise palliated the agonizing sufferings, and stimulating appetite improves sleep, prolongs life, improves the nature cure rate greatly.
6, chronic hepatitis patient (Type B, C type), after receiving treatment, but recovering liver function, the transformation of prevention liver cirrhosis or hepatocarcinoma.
7, this therapy can be treated voluntarily, when the patient requires to leave hospital, for recurrence or the transfer that prevents cancer, should follow the doctor's advice continued treatment.
8, intrapleural injection can reduce hydrothorax.
This therapy is widely used in various dermatosiss and immunological diseases,
Hepatocarcinoma, gastric cancer, colorectal cancer, breast carcinoma, skin carcinoma, other tumors, abscess, anaphylaxis dermatosis, dermatosis, diseases associated with inflammation; Difficult disease, diabetes, hypertension, hypotension, energy goes down, heart disease, arteriosclerosis, apoplexy,, angiopathy; Hepatitis B, C type hepatitis, liver cirrhosis, liver detoxification, respiratory tract disease, pulmonary tuberculosis, laryngitis, flu, asthma; Pneumonia, kidney disease, edema, lymphoma, haemodialysis, immunization therapy, lipid therapy, thrombus treatment, or the like
Clinical experiment:
Experiment 2: splash into this extract in the blood, the immunocyte that can observe in the blood quickens.
Experiment 3: topical administration, curative effect are also fine.
Claims (2)
1. treat tumor disease and the pharmaceutical composition that improves immunity for one kind, by weight, Herba Visci 35-60 ﹪ contained in the compositions; The Radix Astragali 8-15 ﹪; , Radix Scutellariae 8-15 ﹪, Rhizoma Coptidis 8-15 ﹪, Fructus Gardeniae 8-20 ﹪.
2. a kind of tumor disease and pharmaceutical composition that improves immunity of treating according to claim 1 is characterized in that, adds Herba Taraxaci 5-8 ﹪ in the above medicine.
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| CN2012102624180A CN102764324A (en) | 2012-07-27 | 2012-07-27 | Medicine composition for treating neoplastic diseases and improving immunity |
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| CN2012102624180A CN102764324A (en) | 2012-07-27 | 2012-07-27 | Medicine composition for treating neoplastic diseases and improving immunity |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104645111A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Nasopharyngeal carcinoma liver soothing and depression resolving agent and preparation method thereof |
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| CN1491694A (en) * | 2003-08-27 | 2004-04-28 | 山东中医药大学 | Anti-cancer medicine and its producing method |
| CN1823987A (en) * | 2005-12-30 | 2006-08-30 | 山东省中医药研究院 | Application of coptic toxin resolving decoction in preparation of medicine for predventing and treating tumour chemotherapy tolerance |
| CN101837066A (en) * | 2009-03-18 | 2010-09-22 | 复旦大学 | Application of golden thread detoxication decoction as compound preparation in preparing IOD active medicaments |
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- 2012-07-27 CN CN2012102624180A patent/CN102764324A/en active Pending
Patent Citations (3)
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| CN1491694A (en) * | 2003-08-27 | 2004-04-28 | 山东中医药大学 | Anti-cancer medicine and its producing method |
| CN1823987A (en) * | 2005-12-30 | 2006-08-30 | 山东省中医药研究院 | Application of coptic toxin resolving decoction in preparation of medicine for predventing and treating tumour chemotherapy tolerance |
| CN101837066A (en) * | 2009-03-18 | 2010-09-22 | 复旦大学 | Application of golden thread detoxication decoction as compound preparation in preparing IOD active medicaments |
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| CN104645111A (en) * | 2015-03-11 | 2015-05-27 | 王立湖 | Nasopharyngeal carcinoma liver soothing and depression resolving agent and preparation method thereof |
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Application publication date: 20121107 |
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