CN105920238A - Medicine for treating Qi-stagnation and blood stasis type pelvic inflammation and preparation method thereof - Google Patents

Medicine for treating Qi-stagnation and blood stasis type pelvic inflammation and preparation method thereof Download PDF

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CN105920238A
CN105920238A CN201610336912.5A CN201610336912A CN105920238A CN 105920238 A CN105920238 A CN 105920238A CN 201610336912 A CN201610336912 A CN 201610336912A CN 105920238 A CN105920238 A CN 105920238A
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weight
radix
herba
medicine
stagnation
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王丽丽
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Yantai Minwang Electromechanical Technology Co Ltd
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Yantai Minwang Electromechanical Technology Co Ltd
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    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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Abstract

The invention discloses medicine for treating Qi-stagnation and blood stasis type pelvic inflammation and a preparation method thereof, wherein the medicine is prepared from the following medicinal materials including beefwood-like clubmoss herb, curious kadsura roots or stems, Chinese clovershrub roots, homalomena rhizome, trifoliate acanthopanax roots or root-bark, white chinaure herb, Japanese inula herb, radix anemones rivularis, oval kumquat roots, gaultheria pyroloides, loquat seeds, finger citron flowers, chinese buckeye seeds, fructus citri, lathyrus davidii, perilla leaves, pummelo seeds, roses, acanthopanax roots, semen hoveniae, manyinflorescenced sweetvetch roots, capitate knotweed herb, common claoxylon roots and leaves, hypericum japonicum, Tonkin pepper herb, chun spicebush roots, lamiophlomis rotate, rapeseeds, statice sinensis girald, lacca and peach blossoms. The medicine has the efficacies of relaxing the muscles, stimulating the blood circulation, soothing the liver, regulating Qi, tonifying Qi, strengthening exterior, eliminating stagnation, relieving pain and promoting blood circulation to remove blood stasis, and is mainly used for treating the Qi-stagnation and blood stasis type pelvic inflammation; when the medicine is used for treating the Qi-stagnation and blood stasis type pelvic inflammation, both symptoms and root causes are treated; the effect is good; the curative effect taking speed is high; reoccurrence cannot occur; no toxic and side effects exist; the holism concept is emphasized; the curative effect is obvious; no side effect exists; and meanwhile, the integral immunity can be improved.

Description

A kind of medicine treating qi stagnation and blood stasis type pelvic inflammatory disease and preparation method thereof
Technical field
The present invention relates to containing the medicinal preparation deriving from plant, animal or raw mineral materials, particularly to a kind of medicine treating qi stagnation and blood stasis type pelvic inflammatory disease and preparation method thereof.
Background technology
Female pelvic cavity genitals and connective tissue about, when pelvic peritoneum is inflamed, referred to as pelvic inflammatory disease, including metritis, adnexitis, inflammation of pelvic connective tissue and pelvioperitonitis, can fall ill at one or a few place simultaneously, be one of commonly encountered disease.Due to fallopian tube, ovary is referred to as adnexa, and fallopian tube inflammation involves the ovary of neighbour often.Therefore, there is again the title of adnexitis.
Clinical manifestation
The symptom feature of acute pelvic inflammatory disease is: it is sick anxious, and state of an illness weight may occur in which hypogastralgia, fever, shiver with cold, headache, inappetence, finds during inspection that patient is face of acute ill, fever, heart rate is fast, and hypogastric region has muscle tonus, tenderness and rebound tenderness, pelvioscopy: vagina has substantial amounts of purulent secretion, fornix has substantially tenderness, and uterus and double accessory have tenderness, rebound tenderness, or side adnexa thickens.The symptom feature of chronic pelvic inflammatory disease is: it is sick slow, and the course of disease is long, and how inconspicuous General Symptoms is, can have low grade fever, susceptible tired, companion's lower abdomen pendant lumbago etc., finds, Chang Chenghou position, uterus, limitation of activity, or adhesion is fixed during inspection.
Symptom and sign:
Symptom: how inconspicuous (1) General Symptoms is, sometimes can there is low grade fever, susceptible tired, course of disease time relatively elder, some patients can have neurasthenia symptom, and such as lassitude, the whole body is uncomfortable, insomnia etc., when patient's resistance difference, tend to have acute or subacute outbreak, the cicatricial adhesion of (2) chronic inflammatory disease formation and pelvic congestion, hypogastric region falling inflation can be caused, pain and lumbosacral region are ached, and often aggravate after fatigue, sexual intercourse and before and after menstruation, (3) due to pelvic congestion, patient can have menstruation to increase;Menoxenia can be had during ovarian function infringement;Fallopian tube adhesion can cause infertile when blocking.
Sign: Chang Chenghou position, uterus, limitation of activity or adhesion are fixed, if salpingitis, then contact in one or both sides, uterus and increase thick fallopian tube, in rope strip, and have mild tenderness, if hydrosalpinx or tubo-ovarian cyst, then touching Cystic lesions in pelvic cavity one or both sides, how limited activity is, if during inflammation of pelvic connective tissue, one or both sides, uterus have lamellar to thicken, tenderness, and uterosacral ligament increases thick, hardening, there is tenderness.
Diagnosis: have acute pelvic inflammatory disease history and sings and symptoms person, diagnosis is many without difficulty, but patients symptomatic is more sometimes, and without obvious pelvic inflammatory disease medical history and positive sign, now the diagnosis to chronic pelvic inflammatory disease must be prudent, in order to avoid rashness is made diagnosis and is caused patient's mental burden, sometimes pelvic congestion or broad ligament angular vein varicose also can produce the symptom of similar chronic inflammatory disease, chronic pelvic inflammatory disease is difficult to endometriosis differentiate sometimes, endometriosis dysmenorrhea is more significant, if typical case's tuberosity can be touched, contribute to diagnosis, differentiate feasible laparoscopy during difficulty, hydrosalpinx or tubo-ovarian cyst need to differentiate with ovarian cyst, the former is in addition to having pelvic inflammatory disease medical history, lump is sausage type, cyst wall is relatively thin, around there is adhesion;And ovarian cyst is typically with circular or oval more, around without adhesion, activity freely, pelvic inflammatory accessory installation and surrounding adhesion, inertia, sometimes obscure mutually with ovarian cancer, inflammatory mass is capsule and ovarian cancer is reality, and B-mode ultrasonography contributes to discriminating.
Acute chronic pelvic inflammatory disease is according to medical history, and sings and symptoms may be made that diagnosis, but must carry out Differential Diagnosis, and the Differential diagnosis of acute pelvic inflammatory disease has: acute appendicitis, ectopic pregnancy, torsion of the pedicle of ovarian cyst etc.;The Differential diagnosis of chronic pelvic inflammatory disease has: endometriosis and ovarian cancer.
Acute pelvic inflammatory disease has actute infection medical history, lower abdomen dull pain, muscular tone, has tenderness and rebound tenderness, fast with heart rate, heating, vagina has a large amount of purulent secretion, can have high heat, headache, shiver with cold when being in a bad way, inappetence, substantial amounts of yellow leucorrhea has taste, lower abdominal distention pain, tenderness, and waist is ached;Occur feeling sick when having peritonitis, abdominal distention, vomiting, diarrhoea etc.;When having pus bulging to become, can have lower abdomen enclosed mass and local compression irritation, enclosed mass is located anteriorly dysuria, frequent micturition, dysurea etc., and enclosed mass is located behind causing diarrhoea.
Chronic pelvic inflammatory disease General Symptoms is low grade fever, susceptible fatigue sometimes, and some patients neurasthenia symptom occurs due to course of disease length, such as insomnia, lassitude, the whole body is uncomfortable, hypogastric region falling inflation, pain and lumbosacral region are ached, often in fatigue, after sexual intercourse, aggravate before and after menstruation, cause pelvic congestion, menorrhagia due to chronic inflammatory disease, there will be menoxenia during ovarian function infringement, infertility when fallopian tube is adhered obstruction, can be caused.
Symptoms: 1. chronic pelvic inflammatory disease mainly shows as hypogastric region falling inflation, pain and lumbosacral region are ached, and are sometimes also possible to rectal tenesmus uncomfortable, often in fatigue, aggravate after sexual intercourse and before and after menstruation, this is because caused by the cicatricial adhesion that formed of chronic inflammatory disease and pelvic congestion.2. due to pelvic congestion, the symptoms such as patient can have leucorrhoea grow in quantity, and menstruation increases, dysmenorrhea;Menoxenia can be had during ovarian function infringement;Fallopian tube adhesion can cause infertile when blocking.3. how inconspicuous General Symptoms is, sometimes can have low grade fever, susceptible tired, course of disease time relatively elder, and some patients can have neurasthenia symptom.4., during gynecologial examination, if adnexitis, the thick streak thing of increasing or sheet block can be laid one's hand in the one or both sides in uterus, and with mild tenderness;As formed hydrosalpinx or cyst of fallopian tube, the most accessible capsule enclosed mass;If inflammation of pelvic connective tissue, then both sides, uterus can thicken in the form of sheets and have tenderness in various degree.
Therapeutic modality: 1. general treatment releases patient's thought misgivings, strengthens the confidence for the treatment of, has additional nutrients, take exercises, note striking a proper balance between work and rest, and improves Abwehrkraft des Koepers.2. the optimal stimulation of physiotherapy warm can promote pelvic cavity local blood circulation, improves the nutritional status of tissue, improves metabolism, in order to the absorption of inflammation with disappear, conventional has shortwave, ultrashort wave, ion-transmission (can add various medicine such as penicillin, streptomycin etc.), wax therapy etc..3. other drug is treated when using anti-inflammatory drug, also can use Chymetin 5mg or hyaluronidase 1500U simultaneously, intramuscular injection, the next day 1 time, it it is for 5~10 times a course for the treatment of, in order to adhesion and the absorption of inflammation, few patients locally or systemically occurs answering drug withdrawal, in some cases during anaphylaxis, antibiotic is applied with dexamethasone simultaneously, oral dexamethasone 0.75mg, three times a day, notes gradually decrement during drug withdrawal.4. operative treatment has lump such as hydrosalpinx or the treatment of tubo-ovarian cyst operable;There is little focus of infection, the person that repeatedly causes inflammatory episode also suitable operative treatment, perform the operation thoroughly to cure as principle, avoid leaving over focus and have the chance of recurrence again, the unilateral adnexectomy of row or Total hysterectomy add bilateral adnexectomy, should try one's best young woman Ovary conservation function, chronic pelvic inflammatory disease monotherapy effect is poor, uses Comprehensive Treatment to be advisable.
Chinese medical discrimination is divided into: 1. noxious dampness accumulates Sheng type: generate heat before and after row, lower abdominal pain tenderness, band yellow skin or smelly, and yellowish or reddish urine is defecated uncomfortable.Yellow and greasy fur, red tongue, rolling pulse.2. qi stagnation and blood stasis type: lower abdominal pain tenderness, or have low grade fever, lumbosacral aching pain, dysmenorrhea, distention and pain of breast before menstruation, menoxenia, pelvic cavity has enclosed mass.Body of the tongue is purple dim or has petechia, thready and stringy pulse.3. zang-fu disharmony type: pelvic cavity chronic inflammatory disease is delayed for many years, sacrum soreness of waist pain, through row aggravation, tired, have a dizzy spell, anorexia loose stool.Greasy fur, light red tongue is purple, while there is petechia, thready and weak pulse.
Western medical treatment mode toxic and side effects is relatively big, and by comparison, Chinese traditional treatment is more ecological does not has toxic and side effects, has more preferable effect.
Summary of the invention
The technical problem to be solved is, it is provided that a kind of medicine, has effect of relaxing muscles and tendons to promote blood circulation, depressed liver-energy dispersing and QI regulating, benefiting QI for strengthening the superficies, eliminating stasis to stop pain, blood circulation promoting and blood stasis dispelling, cures mainly qi stagnation and blood stasis type pelvic inflammatory disease.The present invention treats qi stagnation and blood stasis type pelvic inflammatory disease, internal and external application, and effective, curative effect is fast, does not recurs, and does not has toxic and side effects, payes attention to organic conception, evident in efficacy, is free from side effects, can improve overall immunity simultaneously.
For solving above-mentioned technical problem, the present invention provides a kind of medicine treating qi stagnation and blood stasis type pelvic inflammatory disease, including following raw medicinal material: Lycopodium casuarinoides Spring, Radix seu Caulis Kadsurae Heteroclitae, Radix Campylotropis Macrocarpae, Rhizoma Homalomenae, Radix Acanthopanacis Trifoliati, Herba Boenninghauseniae Albiflorae, Herba Inulae, Radix Anemones Rivularis, Radix Fortunellae Margaritae, Gaultheria, Radix Eriobotryae, Flos Citri Sarcodactylis, Semen Aesculi, Fructus Citri, Herba lathyri davidii, Folium Perillae, Semen Citri grandis, Flos Rosae Rugosae, Radix Et Caulis Acanthopanacis Senticosi, Japanese raisintree fruit, Radix Hedysari, Herba Polygoni Capitati, Ramulus et Folium Claoxyli, Herba Hyperici Japonici, Herba Piperris Tonkinensis, Radix Linderae Chunii, Radix Lamiophlomidis Rotatae, Semen Brassicae Campestris, Radix limonii sinensis, Lacca and Flos persicae.
nullWherein,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 15-25 weight portion、Radix seu Caulis Kadsurae Heteroclitae 10-15 weight portion、Radix Campylotropis Macrocarpae 7-12 weight portion、Rhizoma Homalomenae 5-9 weight portion、Radix Acanthopanacis Trifoliati 4-8 weight portion、Herba Boenninghauseniae Albiflorae 15-20 weight portion、Herba Inulae 1-3 weight portion、Radix Anemones Rivularis 1-2 weight portion、Radix Fortunellae Margaritae 15-25 weight portion、Gaultheria 10-20 weight portion、Radix Eriobotryae 6-12 weight portion、Flos Citri Sarcodactylis 5-9 weight portion、Semen Aesculi 10-15 weight portion、Fructus Citri 8-14 weight portion、Herba lathyri davidii 6-12 weight portion、Folium Perillae 15-25 weight portion、Semen Citri grandis 10-20 weight portion、Flos Rosae Rugosae 15-25 weight portion、Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion、Japanese raisintree fruit 10-20 weight portion、Radix Hedysari 7-14 weight portion、Herba Polygoni Capitati 10-20 weight portion、Ramulus et Folium Claoxyli 2-4 weight portion、Herba Hyperici Japonici 8-13 weight portion、Herba Piperris Tonkinensis 4-8 weight portion、Radix Linderae Chunii 5-10 weight portion、Radix Lamiophlomidis Rotatae 1-3 weight portion、Semen Brassicae Campestris 8-14 weight portion、Radix limonii sinensis 10-20 weight portion、Lacca 1-3 weight portion and Flos persicae 15-20 weight portion.
nullWherein,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 15-20 weight portion、Radix seu Caulis Kadsurae Heteroclitae 10-15 weight portion、Radix Campylotropis Macrocarpae 7-12 weight portion、Rhizoma Homalomenae 5-9 weight portion、Radix Acanthopanacis Trifoliati 4-8 weight portion、Herba Boenninghauseniae Albiflorae 15-20 weight portion、Herba Inulae 1-3 weight portion、Radix Anemones Rivularis 1-2 weight portion、Radix Fortunellae Margaritae 15-20 weight portion、Gaultheria 15-20 weight portion、Radix Eriobotryae 6-12 weight portion、Flos Citri Sarcodactylis 5-9 weight portion、Semen Aesculi 10-15 weight portion、Fructus Citri 8-10 weight portion、Herba lathyri davidii 6-12 weight portion、Folium Perillae 20-25 weight portion、Semen Citri grandis 15-20 weight portion、Flos Rosae Rugosae 15-20 weight portion、Radix Et Caulis Acanthopanacis Senticosi 7-10 weight portion、Japanese raisintree fruit 15-20 weight portion、Radix Hedysari 7-10 weight portion、Herba Polygoni Capitati 15-20 weight portion、Ramulus et Folium Claoxyli 2-4 weight portion、Herba Hyperici Japonici 8-10 weight portion、Herba Piperris Tonkinensis 4-8 weight portion、Radix Linderae Chunii 5-10 weight portion、Radix Lamiophlomidis Rotatae 1-3 weight portion、Semen Brassicae Campestris 8-10 weight portion、Radix limonii sinensis 15-20 weight portion、Lacca 1-3 weight portion and Flos persicae 15-20 weight portion.
nullWherein,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 17 weight portion、Radix seu Caulis Kadsurae Heteroclitae 12 weight portion、Radix Campylotropis Macrocarpae 9 weight portion、Rhizoma Homalomenae 7 weight portion、Radix Acanthopanacis Trifoliati 6 weight portion、Herba Boenninghauseniae Albiflorae 17 weight portion、Herba Inulae 2 weight portion、Radix Anemones Rivularis 2 weight portion、Radix Fortunellae Margaritae 18 weight portion、Gaultheria 15 weight portion、Radix Eriobotryae 8 weight portion、Flos Citri Sarcodactylis 6 weight portion、Semen Aesculi 12 weight portion、Fructus Citri 12 weight portion、Herba lathyri davidii 12 weight portion、Folium Perillae 18 weight portion、Semen Citri grandis 12 weight portion、Flos Rosae Rugosae 16 weight portion、Radix Et Caulis Acanthopanacis Senticosi 12 weight portion、Japanese raisintree fruit 15 weight portion、Radix Hedysari 9 weight portion、Herba Polygoni Capitati 15 weight portion、Ramulus et Folium Claoxyli 2 weight portion、Herba Hyperici Japonici 12 weight portion、Herba Piperris Tonkinensis 6 weight portion、Radix Linderae Chunii 7 weight portion、Radix Lamiophlomidis Rotatae 1 weight portion、Semen Brassicae Campestris 12 weight portion、Radix limonii sinensis 16 weight portion、Lacca 2 weight portion and Flos persicae 17 weight portion.
nullWherein,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 19 weight portion、Radix seu Caulis Kadsurae Heteroclitae 14 weight portion、Radix Campylotropis Macrocarpae 8 weight portion、Rhizoma Homalomenae 8 weight portion、Radix Acanthopanacis Trifoliati 7 weight portion、Herba Boenninghauseniae Albiflorae 16 weight portion、Herba Inulae 2 weight portion、Radix Anemones Rivularis 2 weight portion、Radix Fortunellae Margaritae 18 weight portion、Gaultheria 17 weight portion、Radix Eriobotryae 10 weight portion、Flos Citri Sarcodactylis 7 weight portion、Semen Aesculi 12 weight portion、Fructus Citri 9 weight portion、Herba lathyri davidii 8 weight portion、Folium Perillae 23 weight portion、Semen Citri grandis 17 weight portion、Flos Rosae Rugosae 17 weight portion、Radix Et Caulis Acanthopanacis Senticosi 8 weight portion、Japanese raisintree fruit 18 weight portion、Radix Hedysari 8 weight portion、Herba Polygoni Capitati 17 weight portion、Ramulus et Folium Claoxyli 2 weight portion、Herba Hyperici Japonici 9 weight portion、Herba Piperris Tonkinensis 6 weight portion、Radix Linderae Chunii 7 weight portion、Radix Lamiophlomidis Rotatae 2 weight portion、Semen Brassicae Campestris 9 weight portion、Radix limonii sinensis 16 weight portion、Lacca 2 weight portion and Flos persicae 18 weight portion.
In order to achieve the above object, present invention also offers the preparation method of described medicine, wherein, the dosage form of described medicine is injection liquor, and its preparation method is:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1~10 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 96%;
Second step, the ethanol that determining alcohol is 85%~95% of the quality 3 relative to described mixed powder~5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24~36 hours under conditions of 5 DEG C~10 DEG C, use percolation with per minute 1~2ml speed slowly percolation, collect percolate, it is concentrated and dried, and pulverizing 40~60 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 0.1~10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%;
3rd step, takes mixed powder 10g~20g that second step obtains, and adds propylene glycol 20g~40g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g~1.5g needle-use activated carbon, be sufficiently stirred for 40~50 minutes;Decarbonization filtering;With 0.22~0.24 μm filtering with microporous membrane;Lyophilization obtains sterilized powder, subpackage embedding and get final product.
Wherein, the dosage form of described medicine is tablet, and its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2~the ethanol that determining alcohol is 80~90% of 4 times, is heated to reflux 1~3 hour, extracts, and filters and obtains the first extracting solution;Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80~90% relative to described medicinal residues quality 1~2 times, be heated to reflux 1~3 hour, extract, filter and obtain the second extracting solution;First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 1~2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
3rd step, the micropowders that second step is obtained, add relative to its quality 0.1~the microcrystalline Cellulose of 0.2 times, 0.01~0.1 times of lactose, starch of 0.1~0.3 times, sieve, mix homogeneously, pelletize, it is dried, adds relative to micropowders quality 0.001~0.01 times of magnesium stearate, granulate, tabletting, makes.
Wherein, the dosage form of described medicine is syrup, and its preparation method is:
The first step, is mixed Radix Eriobotryae, Flos Citri Sarcodactylis, Semen Aesculi and Fructus Citri in described ratio, dissolves with the ethanol of the determining alcohol 85%~95% of 3~5 times of the mixture quality relative to acquisition, extracts after being heated to reflux 2~4 hours, filters, obtain the first filtrate;Filtering residue is dissolved with the ethanol of the determining alcohol 85%~95% of 1~2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1~2 hour, filter, obtain the second filtrate;Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8~0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%~95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder;
Second step, Japanese raisintree fruit, Radix Hedysari, Herba Polygoni Capitati and Ramulus et Folium Claoxyli are mixed in described ratio, the alcohol heating reflux adding the determining alcohol 85%~95% relative to 2~4 times of mixture quality obtained extracts 1~2 time, extracting solution merges, it is centrifuged remove impurity with tube centrifuge, when extracting solution after remove impurity is evaporated under conditions of 60 DEG C~70 DEG C 60 DEG C, relative density is the mastic of 1.20~1.23, and the mastic spray dryer after concentrating is dried to powder;
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 2~4 times of mixture quality obtained, and heating decocts 2~4 hours, filters;By filtering residue again with the water dissolution of 1~2 times of the mixture quality relative to acquisition, heating decoction 1~2 hour, filter;Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add relative to mixture quality 1.5~the water dissolution of 2 times, with 40% sodium hydroxide solution regulation pH value to 7.0, stir evenly, cold preservation 48 hours~72 hours under the conditions of 4 DEG C~8 DEG C, filtering, filtrate adds relative to the mixture quality 0.2 obtained~the sucrose of 0.4 times, stirs and dissolves, regulation pH value, to 7.0, adds water appropriate, stirring, static 12~18 hours, filter, fill, sterilizing, it is thus achieved that syrup.
Wherein, the dosage form of described medicine is: tablet, film coated tablet, sugar coated tablet, soft capsule drop, suck agent, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, solution, sublimed preparation, suppository, syrup, injection, powder, liniment, spray, drop, patch and liniment.
The invention has the beneficial effects as follows: relaxing muscles and tendons to promote blood circulation of the present invention, depressed liver-energy dispersing and QI regulating, benefiting QI for strengthening the superficies, eliminating stasis to stop pain, effect of blood circulation promoting and blood stasis dispelling, cure mainly qi stagnation and blood stasis type pelvic inflammatory disease.The present invention treats qi stagnation and blood stasis type pelvic inflammatory disease, internal and external application, and effective, curative effect is fast, does not recurs, and does not has toxic and side effects, payes attention to organic conception, evident in efficacy, is free from side effects, can improve overall immunity simultaneously.
Detailed description of the invention
The present invention treats qi stagnation and blood stasis type pelvic inflammatory disease, there is effect of relaxing muscles and tendons to promote blood circulation, depressed liver-energy dispersing and QI regulating, benefiting QI for strengthening the superficies, eliminating stasis to stop pain, blood circulation promoting and blood stasis dispelling, select following raw medicinal material: Lycopodium casuarinoides Spring, Radix seu Caulis Kadsurae Heteroclitae, Radix Campylotropis Macrocarpae, Rhizoma Homalomenae, Radix Acanthopanacis Trifoliati, Herba Boenninghauseniae Albiflorae, Herba Inulae, Radix Anemones Rivularis, Radix Fortunellae Margaritae, Gaultheria, Radix Eriobotryae, Flos Citri Sarcodactylis, Semen Aesculi, Fructus Citri, Herba lathyri davidii, Folium Perillae, Semen Citri grandis, Flos Rosae Rugosae, Radix Et Caulis Acanthopanacis Senticosi, Japanese raisintree fruit, Radix Hedysari, Herba Polygoni Capitati, Ramulus et Folium Claoxyli, Herba Hyperici Japonici, Herba Piperris Tonkinensis, Radix Linderae Chunii, Radix Lamiophlomidis Rotatae, Semen Brassicae Campestris, Radix limonii sinensis, Lacca and Flos persicae.
Wherein, Lycopodium casuarinoides Spring, Radix seu Caulis Kadsurae Heteroclitae, Radix Campylotropis Macrocarpae, Rhizoma Homalomenae, Radix Acanthopanacis Trifoliati, Herba Boenninghauseniae Albiflorae, Herba Inulae, Radix Anemones Rivularis, Radix Fortunellae Margaritae, Gaultheria relaxing muscles and tendons to promote blood circulation;Radix Eriobotryae, Flos Citri Sarcodactylis, Semen Aesculi, Fructus Citri, Herba lathyri davidii, Folium Perillae, Semen Citri grandis, Flos Rosae Rugosae depressed liver-energy dispersing and QI regulating;Radix Et Caulis Acanthopanacis Senticosi, Japanese raisintree fruit, Radix Hedysari benefiting QI for strengthening the superficies;Herba Polygoni Capitati, Ramulus et Folium Claoxyli, Herba Hyperici Japonici, Herba Piperris Tonkinensis, Radix Linderae Chunii eliminating stasis to stop pain;Radix Lamiophlomidis Rotatae, Semen Brassicae Campestris, Radix limonii sinensis, Lacca, Flos persicae blood circulation promoting and blood stasis dispelling.Ingredients science is arranged in pairs or groups, scientific matching, thus reaches to treat the purpose of qi stagnation and blood stasis type pelvic inflammatory disease.
The pharmacology being respectively raw medicinal material is as follows:
Lycopodium casuarinoides Spring: [nature and flavor] " Traditional Chinese Medicine in Sichuan will ": " warm in nature, taste is micro-sweet, nontoxic." [function cures mainly] 1. " Traditional Chinese Medicine in Sichuan will ": " can relaxing muscles and tendons to promote blood circulation.Dispelling the wind and dampness pathogens arthralgia, traumatic injury, bones and muscles pain, menoxenia and tetany." 2. " Guangxi practicality Chinese herbal medicine newly selects ": " relaxing muscles and tendons and activating QI and blood in the collateral, antiinflammatory dehumidifies.Cure mainly nyctalopia, night sweat, lumbago due to pathogenic wind-dampness, infantile fever caused by exogenous pathogens."
Radix seu Caulis Kadsurae Heteroclitae: [nature and flavor] " choosing of Simao, Yunnan Chinese herbal medicine ": " micro-cover with mat pungent, temperature." [function cures mainly] expelling wind and removing dampness, promoting flow of QI and blood.Dispelling the wind and dampness pathogens arthralgia pain, gastric and duodenal ulcers, acute/chronic gastroenteritis, dysmenorrhea, puerperal abdonimal pain, traumatic injury.1. " register planted by Guangxi medicine ": " stem: bring down a fever, quenches the thirst.Control cough, liver lung-heat." 2. " Guangxi Chinese herbal medicine ": " promoting blood circulation to remove blood stasis, promoting the circulation of QI to relieve pain.Wind-damp dispelling.Control traumatic injury, rheumatic ostalgia, dysmenorrhea, puerperal abdonimal pain. acute/chronic gastroenteritis." 3. " Guangxi practicality Chinese herbal medicine newly selects ": " dispels the wind, analgesia, relaxing muscles and tendons to promote blood circulation." 4. " choosing of Yunnan Chinese herbal medicine "): " rattan: treat for stomachache, gastric and duodenal ulcers."
Radix Campylotropis Macrocarpae: [nature and flavor] are bitter;Micro-pungent;Flat .[return through] liver;Spleen channel .[function cures mainly] dispelling wind to relieve the exterior syndrome;Control blood dredging collateral.Main anemofrigid cold;Acute filthy disease;Oedema due to nephritis;Numb limbs and tense tendons;Hemiplegia.
Rhizoma Homalomenae: [nature and flavor] are bitter, pungent, temperature.[return through] returns liver, kidney channel.[function cures mainly] wind-damp dispelling, muscle reinforcing and bone strengthening, promoting blood circulation and stopping pain.For anemofrigid-damp arthralgia, chills and pain of the waist and kness, lower limb contracture is numb.
Radix Acanthopanacis Trifoliati: [nature and flavor] toil is cool.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " warm in nature, bitter in the mouth is pungent." 2. " the SHENGCAO property of medicine is standby to be wanted ": " bitter in the mouth is pungent, cold nature." 3. " vegetation just side ": " Gan Xin, is slightly cold." [return through] 1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enters lung, kidney." 2. " east, Fujian book on Chinese herbal medicine ": " enters liver, kidney, stomach three warp." [function cures mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.Cure cold high heat, cough with blood-flecked phlegm, rheumatic arthritis, jaundice, leucorrhea, lithangiuria, traumatic injury, furuncle and phyma skin infection.
Herba Boenninghauseniae Albiflorae: [nature and flavor] " choosing of Yunnan Chinese herbal medicine ": " pungent light, cold.Belly pain is controlled in " [function cures mainly] 1. " will planted by middle traditional Chinese medicines ": " decoction.Leaf is mashed external application and is controlled scald." 2. " choosing of Yunnan Chinese herbal medicine ": " clearing away heat and cooling blood, relaxing muscles and tendons to promote blood circulation, antiinflammatory.Cure cold, pharyngolaryngitis, hepatitis, spitting of blood, epistaxis, lumbago, traumatic injury, ecchymoma."
Herba Inulae: [nature and flavor] are salty, temperature.1. " Suzhou this product medical material ": " salty toil, temperature." 2. " Traditional Chinese Medicine in Sichuan will ": " salty in the mouth, warm in nature." [return through] " Traditional Chinese Medicine in Sichuan will ": " enters lung, large intestine two warp." [function cures mainly] dispersing wind and cold, reduce phlegm drink, detumescence poison.Control cough due to wind and cold, latent fluid-retention phlegm dyspnea, distending pain in the hypochondrium, furuncle, toxic swelling.1. " Japan hanako materia medica ": " only incised wound blood." 2. " detailed outline ": " controls furuncle swelling toxin." 3. " classifying herbal ": " is controlled children's's salt and coughs, and salt is shouted, and rushes meter juice clothes." 4. " Tian Bao book on Chinese herbal medicine ": " lung heat clearing heat extraction, cold expelling reduces internal heat.Stopping vomiting is breathed with cough and is coughed, and tells nosebleed, has one's ideas straightened out treating stranguria." 5. " Nanjing medicinal herbs among the people ": " Seedling: damp eliminating, draws out pus by applying a plaster to the affected part, detumescence, dissipates." 6. " Traditional Chinese Medicine in Sichuan will ": " relieving cough and resolving phlegm, Dingchuan is except drink.Control heart spleen latent fluid-retention, distending pain in the hypochondrium, expectorant knot, saliva such as shellac varnish, and pathogenic wind arthralgia chiefly caused by damp pathogen in lung." 7. " Shaanxi Chinese herbal medicine ": " has relaxing muscles and tendons to promote blood circulation effect."
Radix Anemones Rivularis: [nature and flavor] are pungent, bitter, cold.[function cures mainly] clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.For laryngopharynx swelling and pain, tonsillitis, toothache, stomachache, acute hepatitis, chronic hepatitis, rheumatalgia, traumatic injury.
Radix Fortunellae Margaritae: nature and flavor are bitter, temperature.1. " Traditional Chinese Medicine in Sichuan will ": " acid is sweet, temperature, nontoxic." 2. " east, Fujian book on Chinese herbal medicine ": " toil, temperature." [function cures mainly] circulation of qi promoting, eliminating stagnation.Treat for stomachache and tell food, scrofula, hernia, puerperal abdonimal pain, uterine prolapse.1. " Traditional Chinese Medicine in Sichuan will ": " promoting the circulation of blood dissipates scrofula, qi-regulating and phlegm-dissipating.Treating for stomachache, nine sub-infectionss are from the beginning of not bursting due to stagnation of QI person." 2. " east, Fujian book on Chinese herbal medicine ": " regulating QI sending down the abnormal ascending QI, spleen benefiting and stimulating the appetite, relaxing muscles and tendons and activating QI and blood in the collateral.Control chest and abdomen pain, the stagnant QI rising in reverse order of expectorant, hernia and edema."
Gaultheria: [nature and flavor] are pungent, temperature.[function cures mainly] expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain.For rheumatic arthritis, traumatic injury, cold syndrome of the stomach pain.Anemofrigid cold.
Radix Eriobotryae: [nature and flavor] are bitter is flat.1. " herbal classic is met former ": " Great Cold." 2. " modern Practical Chinese medicinal ": " is bitter, flat." 3. " Traditional Chinese Medicine in Sichuan will ": " cold nature, bitter in the mouth is nontoxic." [return through] " book on Chinese herbal medicine is the newest ": " enters kidney channel." [function cures mainly] preventing phlegm from forming and stopping coughing, depressed liver-energy dispersing and QI regulating.Control cough, hernia, edema, scrofula.1. " detailed outline is picked up any lost article from the road ": " treating the liver is had a surplus all diseases, and QI excess person can use." 2. " book on Chinese herbal medicine is the newest ": " controls hernia, consumer edema, profit joint, controls scrofula." 3. " modern Practical Chinese medicinal ": " relieving cough and expelling phlegm." 4. " Traditional Chinese Medicine in Sichuan will ": " depressed liver-energy dispersing and QI regulating."
Flos Citri Sarcodactylis: [nature and flavor] micro-hardship;Tepor.[return through] liver;Stomach warp.[function cures mainly] depressed liver-energy dispersing and QI regulating;Stomach function regulating soon every.Main stomachache due to hyperactive liver-QI attacking the stomach;Inappetence.
Semen Aesculi: [nature and flavor] " detailed outline ": " sweet, temperature, nontoxic." [return through] " book on Chinese herbal medicine is the newest ": " enters spleen, lung two warp." [function cures mainly] alleviating distention in middle-JIAO, regulates the flow of vital energy, parasite killing.Control cold syndrome of the stomach to have a pain, distension and fullness in the abdomen, infantile malnutrition worm pain, malaria, dysentery.1. " benefit portion square object is slightly remembered ": " eat wind contraction for a long time." 2. " logical refined ": " can the therapeutic method to keep the adverse QI flowing downwards." 3. " detailed outline is picked up any lost article from the road ": " inherited from one's ancestors side of Pueraria lobota, controls heart cold syndrome of the stomach pain, worm pain." " alleviating distention in middle-JIAO therapeutic method to keep the adverse QI flowing downwards, controls gastral cavilty liver diaphragm and expands, infantile malnutrition malaria dysentery, haematemesis impairment caused by overstrain, flat stomach dredging collateral."
Fructus Citri: [nature and flavor] are pungent, bitter, sour, temperature.[return through] returns liver, spleen, lung meridian.[function cures mainly] liver-smoothing, qi-regulating, alleviating distention in middle-JIAO, reduces phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavity abdomen feeling of fullness, vomitting eructation, abundant expectoration is coughed.
Herba lathyri davidii: [nature and flavor] are pungent;Temperature.[return through] Liver Channel.[function cures mainly] depressed liver-energy dispersing and QI regulating;Menstruction regulating and pain relieving.Main dysmenorrhea;Have through uncomfortable.
Folium Perillae: [nature and flavor] are pungent, temperature.1. " not Lu ": " acrid in the mouth, temperature." 2. " a thousand pieces of gold dietetic therapy ": " acrid in the mouth, tepor, nontoxic." 3. amplification on Canon of Materia Medica: " taste is micro-pungent sweet." [return through] enters lung, spleen channel.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " enter spleen, lung two warp." 2. " Bencao Jingshu ": " few the moon of starting with, lunar, Foot yangming Channel." 3. " book on Chinese herbal medicine is through solving ": " enters liver channel of foot-Jueyin, lung meridian." [function cures mainly] delivers, and cold expelling is regulated the flow of vital energy, and battalion.Cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement.And can solving toxin of fish and crab.
Semen Citri grandis: [nature and flavor] are bitter;Flat;Temperature.[return through] Liver Channel.[function cures mainly] depressed liver-energy dispersing and QI regulating;Lung qi dispersing cough-relieving.Main hernia lung cold cough.
Flos Rosae Rugosae: [nature and flavor] sweet micro-hardship, temperature. 1. Yao can become " food book on Chinese herbal medicine ": " sweet and slightly bitter taste, temperature, nontoxic." 2. " occupying diet spectrum with breath ": " sweet, acrid, warm." [return through] " book on Chinese herbal medicine is the newest ": " enters liver, spleen two warp." [function cures mainly] regulates the flow of vital energy resolving depression, and blood dissipating blood stasis.Treating the liver peratodynia, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.
Radix Et Caulis Acanthopanacis Senticosi: [nature and flavor] mildly bitter flavor;Pungent;Warm in nature.[return through] returns spleen;Kidney;Heart channel.[function cures mainly] replenishing kidney, strengthening waist;Benefiting vital QI for tranquillizing;Promoting blood circulation to remove obstruction in the collateral.Main kidney deficiency and bodily weakness;Soreness of the waist and knees;Children's's walking retardation in children;Insufficiency of the spleen weak;Deficiency of vital energy edema;Inappetence;Insomnia and dreamful sleep;Forgetful;Thoracic obstruction pain;Anemofrigid-damp arthralgia;Treating swelling and pain by traumatic injury.
Japanese raisintree fruit: [nature and flavor] sweet acid is flat.1. Tang Materia Medica: " sweet in the mouth, flat, nontoxic.The acid of " 2. " book on Chinese herbal medicine is the newest ": " sweet in the mouth, property is put down, nontoxic." [returning through] 1. " book on Chinese herbal medicine is the newest ": " enters the heart, spleen two warp." 2. " book on Chinese herbal medicine brief points ": " enters meridian of Hand-TAI YIN." [function cures mainly] is controlled drunk, and dysphoria with smothery sensation is thirsty, vomiting, difficulty in urination and defecation.1. " Jingchusuishiji ": " ward off insect poison." 2. Tang Materia Medica: " main wind syndrome of head, lower abdomen contracture." 3. supplement to the Herbal: " relieving restlessness of quenching the thirst, moistening five ZANG-organs, profit defecation, go heat on diaphragm, function such as honey." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " controls all right paralysis of left paralysis, rheumatic numbness, energy alcoholic intoxication;Or steep in wine and take it, also can relaxing muscles and tendons network.Children's takes it, changes worm, supports spleen." 5. " this sketch of the southern regions of the Yunnan Province is said ": " invigorating the spleen and replenishing QI.Phlegm-fire closes to be tied in the heart, can solve with this.’
Radix Hedysari: [nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is routed, blood deficiency and yellow complexion, and interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
Herba Polygoni Capitati: [nature and flavor] toil, temperature.1. " Guangxi Chinese medicinal herbal ": " acrid in the mouth is micro-puckery, warm in nature." 2. " Guangxi Chinese herbal medicine ": " bitter in the mouth is pungent, and property is put down, nontoxic." 3. " Yunnan Chinese herbal medicine ": " acid, cool." [function cures mainly] detoxifies, dissipating blood stasis, inducing diuresis for treating stranguria syndrome.Control dysentery, pyelitis, cystitis, lithangiuria, rheumatalgia, traumatic injury, skin infection eczema.1. " Guangxi Chinese medicinal herbal ": " wind-damp dispelling, eliminating stasis to stop pain.Dispelling the wind and dampness pathogens, traumatic injury." 2. " Guangxi Chinese herbal medicine ": " detoxicating, relieving inflammation.Control dysentery, skin ulcer, innominate toxic swelling." 3. " Yunnan Chinese herbal medicine ": " clearing away heat and promoting diuresis, treating stranguria."
Ramulus et Folium Claoxyli: [nature and flavor] toil, tepor.1. " the SHENGCAO property of medicine is standby to be wanted ": " sweet in the mouth, property is put down." 2. " book on Chinese herbal medicine asks former ": " toil, tepor." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " is light, flat." [function cures mainly] expelling wind and removing dampness, eliminating stasis to stop pain.Treating rheumatic arthritis, lumbago and skelalgia, wound stasis of blood pain.1. " the SHENGCAO property of medicine is standby to be wanted ": " wine clothes are beaten with seven, leaf in wind-damp dispelling foot pain, wine top.Apply traumatic injury, detumescence pain.Its root infusing drugs in wine is still better." 2. " book on Chinese herbal medicine asks former ": " controls all rheumatism wind syndrome due to invasion of wind when drinking." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " method wind dehumidifying, eliminating stasis to stop pain.Treating rheumatic arthritis, lumbago and skelalgia, wound stasis of blood pain, tinea pedis edema."
Herba Hyperici Japonici: nature and flavor hardship sweet, micro-is cool.[function cures mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For hepatitis, early stage liver cirrhosis, appendicitis, eye conjunctivitis, tonsillitis;Furuncle toxic swelling, herpes zoster, venom, traumatic injury are controlled in external.
Herba Piperris Tonkinensis: [nature and flavor] are pungent, temperature.[function cures mainly] expelling wind and cold, eliminating stasis to stop pain.For catching a cold, bones and muscles pain due to rheumatism, treating swelling and pain by traumatic injury, dysmenorrhea, amenorrhea, cold syndrome of the stomach pain;Poisonous snake, centipete bite are controlled in external.
Radix Linderae Chunii: [nature and flavor] Guangzhou army " conventional Chinese herbal medicine handbook ": " pungent, temperature." [function cures mainly] Guangzhou army " conventional Chinese herbal medicine handbook ": " promoting the circulation of QI to relieve pain, dissipating blood stasis for subsidence of swelling.Control treating swelling and pain by traumatic injury, rheumatic ostalgia, flatulence."
Radix Lamiophlomidis Rotatae: [nature and flavor] are bitter, are slightly cold.[function cures mainly] blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.For traumatic injury, fracture, lumbar strain.
Semen Brassicae Campestris: [nature and flavor] are pungent;Sweet;Flat.[return through] liver;Kidney channel.[function cures mainly] blood circulation promoting and blood stasis dispelling;Dispersing swelling and dissipating binds;Loosening bowel to relieve constipation.Main prolonged lochia;Abdominal pain due to blood stasis;Dysmenorrhea;Discharging fresh blood stool;Dysentery;Fengshi Guanjie swells and ache;Carbuncle erysipelas;Acute mastitis;Constipation;Adhesive ileus.
Radix limonii sinensis: [nature and flavor] are bitter;Pungent;Cold in nature.[return through] lung;Liver;Large intestine channel.[function cures mainly] blood circulation promoting and blood stasis dispelling;Clearing and antitussive.Blood stasis mass in the abdomen in main abdomen;Epersalgia cough.
Lacca: [nature and flavor] are bitter, cold.1. Tang Materia Medica: " sweet-salty is flat." 2. " Japan hanako materia medica ": " is nontoxic." 3. " Chinese medicinal herbal ": " is bitter, cold." [function cures mainly] heat clearing away, removing heat from blood, removing toxic substances.Control measles, macule is difficult to send out, puerperal blood faints, leukorrhagia, skin ulcer scabies toxic swelling.
Flos persicae: [nature and flavor] " not Lu ": " bitter in the mouth, flat, nontoxic." [return through] 1. " book on Chinese herbal medicine converge speech ": " start with few the moon, meridian of Foot-JUE YIN." 2. " must join book on Chinese herbal medicine ": " enters Foot yangming Channel." [function cures mainly] diuretic, invigorates blood circulation, relieving constipation.Harness the river swollen, tinea pedis, phlegm retention, stagnant, difficulty in urination and defecation, amenorrhea.1. " not Lu ": " main except aqueous vapor, broken stranguria caused by urinary stone, profit defecation, lower three worms." 2. Tang Materia Medica: " main lower bad odor, detumescence is full, profit intestine and small intestine." 3. " detailed outline ": " profit retained water phlegm retention, stagnant.Control wind mad." 4. " book on Chinese herbal medicine converges and says ": " broken married woman's blood closes abdominal mass due to blood stasis, and blood wind is demented." 5. " south of the Five Ridges gather medicinal herbs record ": " band base of a fruit is used as medicine, can removing pathogenic heat from blood and toxic substance from the body, varioliform exanthema general it."
Described medicine preferably only has above-mentioned medical material and prepares.
Hereinafter using embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1 injects liquor
Formula:
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 1 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 96%;
Second step, the ethanol that determining alcohol is 85% of the quality 4 times relative to described mixed powder is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 36 hours under conditions of 10 DEG C, use percolation with the speed slowly percolation of 2ml per minute, collect percolate, it is concentrated and dried, and pulverizing 60 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 1 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%;
3rd step, takes the mixed powder 15g that second step obtains, and adds propylene glycol 30g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1.5g needle-use activated carbon, be sufficiently stirred for 45 minutes;Decarbonization filtering;With 0.23 μm filtering with microporous membrane;Lyophilization obtains sterilized powder, subpackage embedding and get final product.
Embodiment 2 tablet
Formula: Lycopodium casuarinoides Spring 17 parts, Radix seu Caulis Kadsurae Heteroclitae 12 parts, Radix Campylotropis Macrocarpae 9 parts, Rhizoma Homalomenae 7 parts, Radix Acanthopanacis Trifoliati 6 parts, Herba Boenninghauseniae Albiflorae 17 parts, Herba Inulae 2 parts, Radix Anemones Rivularis 2 parts, Radix Fortunellae Margaritae 18 parts, Gaultheria 15 parts, Radix Eriobotryae 8 parts, Flos Citri Sarcodactylis 6 parts, Semen Aesculi 12 parts, Fructus Citri 12 parts, Herba lathyri davidii 12 parts, Folium Perillae 18 parts, Semen Citri grandis 12 parts, Flos Rosae Rugosae 16 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, Japanese raisintree fruit 15 parts, Radix Hedysari 9 parts, Herba Polygoni Capitati 15 parts, Ramulus et Folium Claoxyli 2 parts, Herba Hyperici Japonici 12 parts, Herba Piperris Tonkinensis 6 parts, Radix Linderae Chunii 7 parts, Radix Lamiophlomidis Rotatae 1 part, Semen Brassicae Campestris 12 parts, Radix limonii sinensis 16 parts, Lacca 2 parts and 17 parts of Flos persicae.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that determining alcohol is 85% relative to mixture quality 3 times, is heated to reflux 2 hours, extracts, and filters and obtains the first extracting solution;Filter the medicinal residues obtained and add the ethanol that determining alcohol is 85% relative to described medicinal residues quality 2 times, be heated to reflux 2 hours, extract, filter and obtain the second extracting solution;First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 2 hours by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that the micropowders of 350 mesh;
3rd step, the micropowders that second step is obtained, add relative to the microcrystalline Cellulose of its quality 0.15 times, 0.05 times of lactose, starch of 0.2 times, sieve, mix homogeneously, pelletizes, and is dried, and adds relative to 0.005 times of magnesium stearate of micropowders quality, granulate, tabletting, make.
Embodiment 3 syrup
Formula: Lycopodium casuarinoides Spring 19 parts, Radix seu Caulis Kadsurae Heteroclitae 14 parts, Radix Campylotropis Macrocarpae 8 parts, Rhizoma Homalomenae 8 parts, Radix Acanthopanacis Trifoliati 7 parts, Herba Boenninghauseniae Albiflorae 16 parts, Herba Inulae 2 parts, Radix Anemones Rivularis 2 parts, Radix Fortunellae Margaritae 18 parts, Gaultheria 17 parts, Radix Eriobotryae 10 parts, Flos Citri Sarcodactylis 7 parts, Semen Aesculi 12 parts, Fructus Citri 9 parts, Herba lathyri davidii 8 parts, Folium Perillae 23 parts, Semen Citri grandis 17 parts, Flos Rosae Rugosae 17 parts, Radix Et Caulis Acanthopanacis Senticosi 8 parts, Japanese raisintree fruit 18 parts, Radix Hedysari 8 parts, Herba Polygoni Capitati 17 parts, Ramulus et Folium Claoxyli 2 parts, Herba Hyperici Japonici 9 parts, Herba Piperris Tonkinensis 6 parts, Radix Linderae Chunii 7 parts, Radix Lamiophlomidis Rotatae 2 parts, Semen Brassicae Campestris 9 parts, Radix limonii sinensis 16 parts, Lacca 2 parts and 18 parts of Flos persicae.
Its preparation method comprises the following steps:
The first step, is mixed Radix Eriobotryae, Flos Citri Sarcodactylis, Semen Aesculi and Fructus Citri in described ratio, dissolves with the ethanol of the determining alcohol 85% of 4 times of the mixture quality relative to acquisition, extracts after being heated to reflux 3 hours, filters, obtain the first filtrate;Filtering residue is dissolved with the ethanol of the determining alcohol 85% of 2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 2 hours, filter, obtain the second filtrate;Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.85g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder;
Second step, Japanese raisintree fruit, Radix Hedysari, Herba Polygoni Capitati and Ramulus et Folium Claoxyli are mixed in described ratio, the alcohol heating reflux adding the determining alcohol 85% relative to 3 times of mixture quality obtained extracts 2 times, extracting solution merges, it is centrifuged remove impurity with tube centrifuge, it is the mastic of 1.22 that extracting solution after remove impurity is evaporated under conditions of 65 DEG C relative density when 60 DEG C, and the mastic spray dryer after concentrating is dried to powder;
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 3 times of mixture quality obtained, and heating decocts 3 hours, filters;By filtering residue again with the water dissolution of 2 times of the mixture quality relative to acquisition, heating decoction 2 hours, filter;Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add the water dissolution relative to mixture quality 1.5 times, with 40% sodium hydroxide solution regulation pH value to 7.0, stir evenly, cold preservation 48 hours under the conditions of 5 DEG C, filtering, filtrate adds the sucrose relative to the mixture quality 0.3 times obtained, and stirs and dissolves, regulation pH value, to 7.0, adds water appropriate, stirring, static 15 hours, filter, fill, sterilizing, it is thus achieved that syrup.
Toxicity test
1. acute toxicity test:
With the tablet of the embodiment of the present invention 2 as object, 200 times of clinical consumption per day offer medicine to the big enteral of white mouse, observe 7.The all animals of result are strong deposits, and its activity, diet, hair, Excreta are no abnormal, have no toxic reaction.White mouse vagina and damaged skin are carried out irritation test, there are no irritative response and other untoward reaction.Toxicity test proves, the medicine of the present invention does not has toxic action and untoward reaction, and clinical practice is safe and reliable.
2. long term toxicity test:
By the syrup of the embodiment of the present invention 3 to mice by 10,15 and 40g crude drugs/kg continuous use 12 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 4 weeks after, result shows: the indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat are all had no significant effect by medicine of the present invention, internal organs naked eyes do not find that difference change and histological indications show, after medication 12 weeks and drug withdrawal 4 weeks, Organs of Mice is all without substantially changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical trial
Case selection:
During choosing in August ,-2014 in August, 2013, the Patients with Pelvic Inflammatory Disease that certain gynaecologic hospital receives is 200 examples.Wherein, 20 examples of less than 20 years old, 20-35 year patient populations 120 people, more than 35 years old patient populations 60 people.Clinical manifestation: generate heat before and after row, lower abdominal pain tenderness, band yellow skin or smelly, yellowish or reddish urine, defecate uncomfortable.Yellow and greasy fur, red tongue, rolling pulse, it is diagnosed as qi stagnation and blood stasis type pelvic inflammatory disease.This 200 example patient is carried out random packet, is divided into embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched group, often organizes 50 people.
Diagnostic criteria:
With reference to " new Chinese medicine guideline of clinical investigations " it " guideline of clinical investigations of new Chinese medicine treatment pelvic inflammatory disease)) " chronic pelvic inflammatory disease diagnostic criteria " in (version in 2002):
1. medical history: have acute pelvic inflammatory disease medical history more.
2. symptom: A. low grade fever, tired: how inconspicuous General Symptoms is, the most only low grade fever, susceptible tired, course of disease elder's some patients may occur in which neurasthenia symptom, such as diseases such as lassitude, whole body discomfort, insomnias.B. lower abdomen falling inflation pain or waist orphan portion distending pain: for clinical cardinal symptom.Because chronic inflammatory disease is formed caused by uterus, fallopian tube adhesion or pelvic cavity addiction blood, pain often increases the weight of before and after fatigue, sexual intercourse, menstruation.C. leucorrhoea grow in quantity: in yellow or yellowish water sample, or yellow green, can frowziness.D. menoxenia: common with menorrhagia or menostaxis, because chronic inflammatory disease causes pelvic cavity addiction blood, or affects caused by ovarian function.The most infertile: because chronic inflammatory disease causes fallopian tube adhesion obstruction caused.
3. sign: uterus is often in retroversioflexion, and limitation of activity or adhesion are fixed, during myometritis, can there be tenderness in uterus;If salpingitis, then touch the thick fallopian tube of streak increasing in one or both sides, uterus, and have tenderness;If hydrosalpinx or tubo-ovarian cyst, then touching Cystic lesions in pelvic cavity one or both sides, how limited activity is, can have tenderness;If during inflammation of pelvic connective tissue, then detain in one or both sides, uterus and lamellar thickens, tenderness;Or have palace can increase thick, hardening, tenderness by ligament.
Above-mentioned sign at least needs to be provided simultaneously with following 2: uterine activity is limited or adhesion is fixing with tenderness;Attachment area (strand increases thick or lamellar thickens or enclosed mass) tenderness.
4. auxiliary examination: A. routine blood test: total white blood cells or neutrophilic granulocyte can be had slightly to increase.B.B is super to be checked: can visit and fallopian tube increases thick, hydrops, or inflammatory masses of pelvic cavity.C. vagina or cervical canal secretions plate coating checking or cultivation: can have abnormal or detection pathogen.D. laparoscopy: visible uterus, fallopian tube adhesion focus or inflammatory masses of pelvic cavity are formed.
According to above-mentioned cardinal symptom, indispensable sign, the most diagnosable in conjunction with medical history and auxiliary examination.
5. qi stagnation and blood stasis type: generate heat before and after row, lower abdominal pain tenderness, band yellow skin or smelly, yellowish or reddish urine, defecate uncomfortable.Yellow and greasy fur, red tongue, rolling pulse.
Therapeutic Method:
Embodiment 1 group: this group uses the injection liquor of embodiments of the invention 1 to treat.Every day 1 time, each intravenous drip.Within 7 days, it is a course for the treatment of, treats 2 courses for the treatment of.
Embodiment 2 groups: this group uses the tablet of embodiments of the invention 2 to treat.Every day 2 times, the most oral 2.Within 7 days, it is a course for the treatment of, treats 2 courses for the treatment of.
Embodiment 3 groups: this group uses the syrup of embodiments of the invention 3 to treat.Every day 2 times, 10ml is administered orally every time.Within 7 days, it is a course for the treatment of, treats 2 courses for the treatment of.
Matched group: this group patient takes Drug therapy: levofloxacin (500mg/ time, 1 times/day, serve on 14) or ofloxacin (4O0mg/ time, 1 times/day, it serve on 14), add simultaneously or be not added with first nitre (500mg/ time, 2 times/day, it serve on 14).
The standard of curative effect evaluation:
Comprehensive therapeutic effect evaluation criteria (with reference to nimodipine method)
Therapeutic index N bis-(integration before (integration after integration one treatment before treating)/treatment) X%
1. recovery from illness: after treatment, transference cure, gynecologial examination and the physico-chemical examination such as hypogastralgia and waist energy distending pain are normal.Syndrome, sign therapeutic index N) 95%.Drug withdrawal is not recurred in January.
The most effective: the transference cure such as hypogastralgia and waist energy distending pain or substantially alleviate after treatment, gynecologial examination and physico-chemical examination are obviously improved.Syndrome, sign therapeutic index N) 7 both, < 95%.
The most effective: after treatment, the symptom such as hypogastralgia and waist energy distending pain alleviates, and gynecologial examination and physico-chemical examination make moderate progress.Syndrome, sign therapeutic index N) 30%, < 70%.
The most invalid: after treatment, the symptom such as hypogastralgia and waist bones of the body distending pain increases the weight of without alleviating or having, gynecologial examination and physico-chemical examination increase the weight of without improving or having.Syndrome, sign therapeutic index N < 30%.
Therapeutic outcome
Table 1 is the treatment situation contrast of each group
Group Recovery from illness Effective Effectively Invalid
Embodiment 1 group 48(96%) 1(2%) 1(2%) 0(0%)
Embodiment 2 groups 49(98%) 0(0%) 1(2%) 0(0%)
Embodiment 3 groups 50(100%) 0(0%) 0(0%) 0(0%)
Matched group 15(30%) 12(24%) 10(20%) 13(26%)
As can be seen from Table 1, the treatment situation of three embodiment groups is better than the therapeutic effect of matched group, it follows that the medicine of the present invention, in treatment qi stagnation and blood stasis type pelvic inflammatory disease, therapeutic effect is good, determined curative effect.
Table 2 is the treatment time contrast of the healing of each group
Group Recovery from illness number First course for the treatment of Second course for the treatment of
Embodiment 1 group 48 24(49%) 25(51%)
Embodiment 2 groups 49 29(59.2%) 20(40.8%)
Embodiment 3 groups 50 28(56%) 22(44%)
Matched group 15 4(26.7%) 11(73.3%)
As can be seen from Table 2, the healing number that first course for the treatment of of three embodiment groups cures is higher than matched group, it follows that the medicine of the present invention, in treatment qi stagnation and blood stasis type pelvic inflammatory disease, treatment speed is fast, instant effect.
Model case: Wang, female, 35 years old, suffer from pelvic inflammatory disease existing a year and a half, Symptoms is: generate heat before and after row, lower abdominal pain tenderness, band yellow skin or smelly, and yellowish or reddish urine is defecated uncomfortable.Yellow and greasy fur, red tongue, rolling pulse, it is diagnosed as qi stagnation and blood stasis type pelvic inflammatory disease.The syrup using embodiments of the invention 3 is treated.Every day 2 times, 10ml is administered orally every time.Within 7 days, it is a course for the treatment of, treats 2 courses for the treatment of.In drug administration process, not occurring that other complication occurs, recovery from illness, complication all eliminates.Without recurrence.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all within the spirit and principles in the present invention, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.

Claims (9)

1. the medicine treating qi stagnation and blood stasis type pelvic inflammatory disease, it is characterized in that, including following raw medicinal material: Lycopodium casuarinoides Spring, Radix seu Caulis Kadsurae Heteroclitae, Radix Campylotropis Macrocarpae, Rhizoma Homalomenae, Radix Acanthopanacis Trifoliati, Herba Boenninghauseniae Albiflorae, Herba Inulae, Radix Anemones Rivularis, Radix Fortunellae Margaritae, Gaultheria, Radix Eriobotryae, Flos Citri Sarcodactylis, Semen Aesculi, Fructus Citri, Herba lathyri davidii, Folium Perillae, Semen Citri grandis, Flos Rosae Rugosae, Radix Et Caulis Acanthopanacis Senticosi, Japanese raisintree fruit, Radix Hedysari, Herba Polygoni Capitati, Ramulus et Folium Claoxyli, Herba Hyperici Japonici, Herba Piperris Tonkinensis, Radix Linderae Chunii, Radix Lamiophlomidis Rotatae, Semen Brassicae Campestris, Radix limonii sinensis, Lacca and Flos persicae.
null2. the medicine treating qi stagnation and blood stasis type pelvic inflammatory disease as claimed in claim 1,It is characterized in that,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 15-25 weight portion、Radix seu Caulis Kadsurae Heteroclitae 10-15 weight portion、Radix Campylotropis Macrocarpae 7-12 weight portion、Rhizoma Homalomenae 5-9 weight portion、Radix Acanthopanacis Trifoliati 4-8 weight portion、Herba Boenninghauseniae Albiflorae 15-20 weight portion、Herba Inulae 1-3 weight portion、Radix Anemones Rivularis 1-2 weight portion、Radix Fortunellae Margaritae 15-25 weight portion、Gaultheria 10-20 weight portion、Radix Eriobotryae 6-12 weight portion、Flos Citri Sarcodactylis 5-9 weight portion、Semen Aesculi 10-15 weight portion、Fructus Citri 8-14 weight portion、Herba lathyri davidii 6-12 weight portion、Folium Perillae 15-25 weight portion、Semen Citri grandis 10-20 weight portion、Flos Rosae Rugosae 15-25 weight portion、Radix Et Caulis Acanthopanacis Senticosi 7-14 weight portion、Japanese raisintree fruit 10-20 weight portion、Radix Hedysari 7-14 weight portion、Herba Polygoni Capitati 10-20 weight portion、Ramulus et Folium Claoxyli 2-4 weight portion、Herba Hyperici Japonici 8-13 weight portion、Herba Piperris Tonkinensis 4-8 weight portion、Radix Linderae Chunii 5-10 weight portion、Radix Lamiophlomidis Rotatae 1-3 weight portion、Semen Brassicae Campestris 8-14 weight portion、Radix limonii sinensis 10-20 weight portion、Lacca 1-3 weight portion and Flos persicae 15-20 weight portion.
null3. the medicine treating qi stagnation and blood stasis type pelvic inflammatory disease as claimed in claim 1 or 2,It is characterized in that,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 15-20 weight portion、Radix seu Caulis Kadsurae Heteroclitae 10-15 weight portion、Radix Campylotropis Macrocarpae 7-12 weight portion、Rhizoma Homalomenae 5-9 weight portion、Radix Acanthopanacis Trifoliati 4-8 weight portion、Herba Boenninghauseniae Albiflorae 15-20 weight portion、Herba Inulae 1-3 weight portion、Radix Anemones Rivularis 1-2 weight portion、Radix Fortunellae Margaritae 15-20 weight portion、Gaultheria 15-20 weight portion、Radix Eriobotryae 6-12 weight portion、Flos Citri Sarcodactylis 5-9 weight portion、Semen Aesculi 10-15 weight portion、Fructus Citri 8-10 weight portion、Herba lathyri davidii 6-12 weight portion、Folium Perillae 20-25 weight portion、Semen Citri grandis 15-20 weight portion、Flos Rosae Rugosae 15-20 weight portion、Radix Et Caulis Acanthopanacis Senticosi 7-10 weight portion、Japanese raisintree fruit 15-20 weight portion、Radix Hedysari 7-10 weight portion、Herba Polygoni Capitati 15-20 weight portion、Ramulus et Folium Claoxyli 2-4 weight portion、Herba Hyperici Japonici 8-10 weight portion、Herba Piperris Tonkinensis 4-8 weight portion、Radix Linderae Chunii 5-10 weight portion、Radix Lamiophlomidis Rotatae 1-3 weight portion、Semen Brassicae Campestris 8-10 weight portion、Radix limonii sinensis 15-20 weight portion、Lacca 1-3 weight portion and Flos persicae 15-20 weight portion.
null4. the medicine of the treatment qi stagnation and blood stasis type pelvic inflammatory disease as described in any one of claims 1 to 3,It is characterized in that,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 17 weight portion、Radix seu Caulis Kadsurae Heteroclitae 12 weight portion、Radix Campylotropis Macrocarpae 9 weight portion、Rhizoma Homalomenae 7 weight portion、Radix Acanthopanacis Trifoliati 6 weight portion、Herba Boenninghauseniae Albiflorae 17 weight portion、Herba Inulae 2 weight portion、Radix Anemones Rivularis 2 weight portion、Radix Fortunellae Margaritae 18 weight portion、Gaultheria 15 weight portion、Radix Eriobotryae 8 weight portion、Flos Citri Sarcodactylis 6 weight portion、Semen Aesculi 12 weight portion、Fructus Citri 12 weight portion、Herba lathyri davidii 12 weight portion、Folium Perillae 18 weight portion、Semen Citri grandis 12 weight portion、Flos Rosae Rugosae 16 weight portion、Radix Et Caulis Acanthopanacis Senticosi 12 weight portion、Japanese raisintree fruit 15 weight portion、Radix Hedysari 9 weight portion、Herba Polygoni Capitati 15 weight portion、Ramulus et Folium Claoxyli 2 weight portion、Herba Hyperici Japonici 12 weight portion、Herba Piperris Tonkinensis 6 weight portion、Radix Linderae Chunii 7 weight portion、Radix Lamiophlomidis Rotatae 1 weight portion、Semen Brassicae Campestris 12 weight portion、Radix limonii sinensis 16 weight portion、Lacca 2 weight portion and Flos persicae 17 weight portion.
null5. the medicine of the treatment qi stagnation and blood stasis type pelvic inflammatory disease as described in any one of Claims 1-4,It is characterized in that,In described medicine, the ratio of weight and number of each raw medicinal material is: Lycopodium casuarinoides Spring 19 weight portion、Radix seu Caulis Kadsurae Heteroclitae 14 weight portion、Radix Campylotropis Macrocarpae 8 weight portion、Rhizoma Homalomenae 8 weight portion、Radix Acanthopanacis Trifoliati 7 weight portion、Herba Boenninghauseniae Albiflorae 16 weight portion、Herba Inulae 2 weight portion、Radix Anemones Rivularis 2 weight portion、Radix Fortunellae Margaritae 18 weight portion、Gaultheria 17 weight portion、Radix Eriobotryae 10 weight portion、Flos Citri Sarcodactylis 7 weight portion、Semen Aesculi 12 weight portion、Fructus Citri 9 weight portion、Herba lathyri davidii 8 weight portion、Folium Perillae 23 weight portion、Semen Citri grandis 17 weight portion、Flos Rosae Rugosae 17 weight portion、Radix Et Caulis Acanthopanacis Senticosi 8 weight portion、Japanese raisintree fruit 18 weight portion、Radix Hedysari 8 weight portion、Herba Polygoni Capitati 17 weight portion、Ramulus et Folium Claoxyli 2 weight portion、Herba Hyperici Japonici 9 weight portion、Herba Piperris Tonkinensis 6 weight portion、Radix Linderae Chunii 7 weight portion、Radix Lamiophlomidis Rotatae 2 weight portion、Semen Brassicae Campestris 9 weight portion、Radix limonii sinensis 16 weight portion、Lacca 2 weight portion and Flos persicae 18 weight portion.
6. the medicine of the treatment qi stagnation and blood stasis type pelvic inflammatory disease as described in any one of claim 1 to 5, it is characterised in that the dosage form of described medicine is injection liquor, and its preparation method is:
The first step, described raw medicinal material is mixed in proportion, put into the mixed powder being ground into the micron particles of 0.1~10 μm volume average particle size and particle diameter in super micron mill less than the nano-scale particle composition of 0.1 μm volume average particle size, described mixed powder powder rate is at least 96%;
Second step, the ethanol that determining alcohol is 85%~95% of the quality 3 relative to described mixed powder~5 times is added in the mixed powder that the first step obtains, stirring and dissolving obtains ethanol solution, ethanol solution is stood 24~36 hours under conditions of 5 DEG C~10 DEG C, use percolation with per minute 1~2ml speed slowly percolation, collect percolate, it is concentrated and dried, and pulverizing 40~60 minutes in super micron mill are put at this, the micron particles and the particle diameter that obtain 0.1~10 μm volume average particle size are less than the mixed powder that the nano-scale particle of 0.1 μm volume average particle size forms, the powder rate that obtains of described mixed powder is at least 95%;
3rd step, takes mixed powder 10g~20g that second step obtains, and adds propylene glycol 20g~40g, adds 200ml water for injection, and stirring makes it dissolve, injects water to 1000ml further, add 1g~1.5g needle-use activated carbon, be sufficiently stirred for 40~50 minutes;Decarbonization filtering;With 0.22~0.24 μm filtering with microporous membrane;Lyophilization obtains sterilized powder, subpackage embedding and get final product.
7. the medicine of the treatment qi stagnation and blood stasis type pelvic inflammatory disease as described in any one of claim 1 to 5, it is characterised in that the dosage form of described medicine is tablet, and its preparation method is:
The first step, is mixed in proportion described each raw medicinal material, adds relative to mixture quality 2~the ethanol that determining alcohol is 80~90% of 4 times, is heated to reflux 1~3 hour, extracts, and filters and obtains the first extracting solution;Filter the medicinal residues obtained and add the ethanol that determining alcohol is 80~90% relative to described medicinal residues quality 1~2 times, be heated to reflux 1~3 hour, extract, filter and obtain the second extracting solution;First extracting solution and the second extracting solution being merged, concentrating under reduced pressure removes alcohol solvent, is dried, it is thus achieved that dry cream;
Second step, is placed in super micron mill pulverizing 1~2 hour by the dry cream that the first step obtains, and pulverizes, sieves, it is thus achieved that 300 mesh~the micropowders of 400 mesh;
3rd step, the micropowders that second step is obtained, add relative to its quality 0.1~the microcrystalline Cellulose of 0.2 times, 0.01~0.1 times of lactose, starch of 0.1~0.3 times, sieve, mix homogeneously, pelletize, it is dried, adds relative to micropowders quality 0.001~0.01 times of magnesium stearate, granulate, tabletting, makes.
8. the preparation method of the medicine of the treatment qi stagnation and blood stasis type pelvic inflammatory disease described in an any one of claim 1 to 5, it is characterised in that the dosage form of described medicine is syrup, and its preparation method is:
The first step, is mixed Radix Eriobotryae, Flos Citri Sarcodactylis, Semen Aesculi and Fructus Citri in described ratio, dissolves with the ethanol of the determining alcohol 85%~95% of 3~5 times of the mixture quality relative to acquisition, extracts after being heated to reflux 2~4 hours, filters, obtain the first filtrate;Filtering residue is dissolved with the ethanol of the determining alcohol 85%~95% of 1~2 times of the mixture quality relative to acquisition again, extracts after being heated to reflux 1~2 hour, filter, obtain the second filtrate;Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8~0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first with deionized water or the distilled water eluting of 5 times of resin column volumes, it is 90%~95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collecting ethanol elution, concentrating under reduced pressure removes ethanol, is dried and is ground into powder;
Second step, Japanese raisintree fruit, Radix Hedysari, Herba Polygoni Capitati and Ramulus et Folium Claoxyli are mixed in described ratio, the alcohol heating reflux adding the determining alcohol 85%~95% relative to 2~4 times of mixture quality obtained extracts 1~2 time, extracting solution merges, it is centrifuged remove impurity with tube centrifuge, when extracting solution after remove impurity is evaporated under conditions of 60 DEG C~70 DEG C 60 DEG C, relative density is the mastic of 1.20~1.23, and the mastic spray dryer after concentrating is dried to powder;
3rd step, is mixed surplus stock medical material in described ratio, adds the water dissolution relative to 2~4 times of mixture quality obtained, and heating decocts 2~4 hours, filters;By filtering residue again with the water dissolution of 1~2 times of the mixture quality relative to acquisition, heating decoction 1~2 hour, filter;Merging the filtrate of twice, concentrating under reduced pressure removes moisture, is dried and is ground into powder;
4th step, the powder mixing that the first step, second step and the 3rd step are obtained, add relative to mixture quality 1.5~the water dissolution of 2 times, with 40% sodium hydroxide solution regulation pH value to 7.0, stir evenly, cold preservation 48 hours~72 hours under the conditions of 4 DEG C~8 DEG C, filtering, filtrate adds relative to the mixture quality 0.2 obtained~the sucrose of 0.4 times, stirs and dissolves, regulation pH value, to 7.0, adds water appropriate, stirring, static 12~18 hours, filter, fill, sterilizing, it is thus achieved that syrup.
9. the medicine of the treatment qi stagnation and blood stasis type pelvic inflammatory disease as described in any one of claim 1 to 5, it is characterized in that, the dosage form of described medicine is: tablet, film coated tablet, sugar coated tablet, soft capsule drop, suck agent, granule, enteric coated tablet, electuary, honey pill agent, oral liquid, solution, sublimed preparation, suppository, syrup, injection, powder, liniment, spray, drop, patch and liniment.
CN201610336912.5A 2016-05-20 2016-05-20 Medicine for treating Qi-stagnation and blood stasis type pelvic inflammation and preparation method thereof Withdrawn CN105920238A (en)

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