CN104644865A - Traditional Chinese medicine composite for treating hemorrhagic necrotic hepatitis in ducks - Google Patents
Traditional Chinese medicine composite for treating hemorrhagic necrotic hepatitis in ducks Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composite for treating hemorrhagic necrotic hepatitis in ducks. The traditional Chinese medicine composite is prepared from the following raw materials by weight: 10-15g capillary artemisia, 10-15g gardenia, 10-15g honeysuckle, 10-15g bighead atractylodes rhizome, 1-2g cinobufagin venom toad, 10-15g radix isatidis, 10-18g radices trichosanthis, 10-12g fructus forsythiae, 10-15g radix scrophularise and 10-15g liquorice. The traditional Chinese medicine composite has better curative effect in treating the hemorrhagic necrotic hepatitis in the ducks induced by duck reovirus; a death rate of the sick ducks can be reduced greatly; recovery of the sick ducks can be facilitated; and the growth development of the sick ducks can recover.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis.
Background technology
Duck hemorrhagic necrotic hepatitis is caused by aquatic birds such as Novel duck reovirus (NDRV) main infection Muscovy duck and Mule duck, (also referred to as Muscovy duck " new hepatopathy ").Duck hemorrhagic necrotic hepatitis clinically main manifestations is liver irregular block/plaque-like necrosis and the hemorrhage epidemic disease mixed for feature.This sick sickness rate 5-40%, reaches as high as 100%, case fatality rate 5-50%.This disease starts south China Guangdong, Guangxi, Fujian, Zhejiang and Jiangxi etc. for 2007 and is widely current, and the sound development of duck industry is supported in serious harm.Poultry outpatient service statistical data according to present invention applicant shows, and this disease is main diseases viral disease popular in duck group, and the 6000000 plumage duck morbidities at annual more than 3000 (families), account for 20% of duck virosis.Cause the economic loss of more than 1,000 ten thousand yuan every year.
Chinese medicine has unique effect in the process for the treatment of viral disease, and a lot of Chinese medicine not only has antivirus action, and energy enhancing immunity, promotion organism metabolism, toxic and side effects is little, medicine source is enriched, cheap, has very high applying value in livestock and poultry disease control and prevention process.But also do not report that what Chinese medicine or Chinese medicine formula have definite therapeutic effect to the hemorrhagic necrotic hepatitis that Novel duck reovirus causes at present.
Summary of the invention
In order to find the active drug for the treatment of duck hemorrhagic necrotic hepatitis, use through large quantifier elimination and clinical practice, inventor have developed effective Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis, greatly can reduce the mortality rate of morbidity duck group, promote the rehabilitation of morbidity duck, recover its growth promoter.
Particularly, inventor provides following technical scheme:
Treating a Chinese medicine composition for duck hemorrhagic necrotic hepatitis, is be made up of the raw material of following weight:
Herba Artemisiae Scopariae 10-15g, Fructus Gardeniae 10-15g, Flos Lonicerae 10-15g, Rhizoma Atractylodis Macrocephalae 10-15g, Venenum Bufonis 1-2g, Radix Isatidis 10-15g, Radix Trichosanthis 10-18g, Fructus Forsythiae 10-12g, Radix Scrophulariae 10-15g, Radix Glycyrrhizae 10-15g.
In Chinese medicine formula of the present invention:
Herba Artemisiae Scopariae: crude drug source is the dry aerial parts of feverfew Herba Artemisiae Scopariae Artemisia capillaris Thunb. or Artemisia scoparia Waldst. et Kit. copariaWaldst.et Kit., another name, Herba Artemisiae montanae Artemisia, Herba Artemisiae Sieversianae, Folium Pini ends.Nature and flavor are bitter, pungent, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.Function: clearing away heat-damp and promoting diuresis, jaundice eliminating.Cure mainly: jaundice, oliguria, eczema pruritus.
Fructus Gardeniae: crude drug source is the ripe dry fruit of Maguireothamnus speciosus Fructus Gardeniae Garenia jasminoides.Nature and flavor bitter cold, GUIXIN lung tri-jiao channel.Function eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood.Cure mainly three burnt intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis, fall apart and hinder pain.
Flos Lonicerae: medicament sources is dry flower or the first flower opened of band of caprifoliaceae plant Radix Ophiopogonis Lonnicera japonica Thunb..Property sweet cold, return lung, the heart, stomach warp.Function heat-clearing and toxic substances removing, expelling wind and cold pathogens.Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, breast swell and pain, carbuncle sore tumefacting virus.
The Rhizoma Atractylodis Macrocephalae: crude drug source is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz..Another name small wooden raft Ji, Rhizoma Atractylodis Macrocephalae, the winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar small wooden raft, Wu Shu, sheet art, Rhizoma Atractylodis etc.Nature and flavor are bitter, sweet, warm.Return spleen, stomach warp.Function invigorating the spleen and replenishing QI, dampness diuretic, antiabortive, hidroschesis.Cure mainly diarrhea due to hypofunction of the spleen, edema, frequent fetal movement, sweating due to debility.
Venenum Bufonis: medicament sources is the dry secretions of Bufonidae animal Bufo siccus Bu fo bu gargarizans Cantor or Bufo melanostictus Bu fo melanostictus Schneider.Another name bufalin; Cinobufacin; Bufogenin.Nature and flavor are sweet, warm, poisonous, GUIXIN warp.Function is detoxified, and pain relieving, has one's ideas straightened out.Cure mainly the yellow furunculosis of skin ulcer, laryngopharynx swelling and pain, heatstroke coma.
Radix Isatidis: the dry root of cruciferae isatis Isatis indigotica Fort..Different name: indigo-blue (" book on Chinese herbal medicine is just read "), Isatis indigotica Fort (Indigofera tinctoria L, Baphicanthus cusia (nees) Brem. Polygonum tinctorium Ait) root (" classifying herbal "), indigo root (" Chinese medicine shape sex experience differential method "), Isatis indigotica Fort. (Tang Materia Medica), great Lan (herbal for Relief of Famines, Liu Yuxi " side of delivering a letter "), Acanthaceous indigo (" Bencao Tujing "), Qian (" elegant "), great Ye winter indigo plant (" elegant " Guo Pu note), ultramarine (" carrying out Cliff rock book on Chinese herbal medicine "), Baphicacanthus cusia (" detailed outline "), mountain is blue, great Lan root, rhizoma et radix baphicacanthis (" book on Chinese herbal medicine is just read "), Lan Longgen, Lumbricus root, large indigo.Nature and flavor: bitter, cold.Gui Jing: return liver; Stomach warp.Effect: heat clearing away, removing toxic substances, removing heat from blood, sore-throat relieving.Cure mainly: maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Crimson tongue is purple dark, scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer is swollen, carbuncle; Chickenpox; Measles; Hepatitis; Influenza, epidemic encephalitis, encephalitis b, pneumonia, coma tells nosebleed, pharyngeal swelling, acute catarrhal conjunctivitis, skin ulcer rash; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.
Radix Trichosanthis: crude drug source is the dry root of cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms richosanthes rosthornii Harm.Sweet, the micro-hardship of nature and flavor, is slightly cold.Attach to the lung and stomach meridians.Function clearing away heat-fire, promoting the production of body fluid to quench thirst, detumescence and apocenosis, cures mainly the greedy drink of high heat, lung-heat type cough, laryngopharynx swelling and pain, pyretic toxicity carbuncle, acute mastitis.
Fructus Forsythiae: crude drug source is the dry fruit of Oleaceae plants Fructus Forsythiae Forsythia suspensa (Thunb.) Vahl.Another name Fructus Forsythiae, Hemerocallis citrina Baroni bar, yellow chain barriness, Huang Qidan, green grass or young crops stick up, fall to sticking up.Nature and flavor are bitter, are slightly cold.Return lung, the heart, small intestine meridian.Function heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison.
Radix Scrophulariae: crude drug source is the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensis Hemsl..Nature and flavor are sweet, bitter, salty, be slightly cold.Function is nourishing YIN to lower pathogenic fire, removing pathogenic heat from blood and toxic substance from the body.Cure mainly consumption of YIN caused by febrile disease, laryngopharynx swelling and pain, the yellow furunculosis of skin ulcer, treaitng Yin-deficiency constipation.
Radix Glycyrrhizae: be the root and rhizome of pulse family herbaceos perennial Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Batal. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..Another name: Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae, Radix Glycyrrhizae.Nature and flavor: sweet are flat.Gui Jing: GUIXIN warp, lung meridian, spleen channel, stomach warp.Function: QI invigorating invigorating middle warmer, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine.Cure mainly: cure mainly deficiency-weakness of spleen-QI, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, pathopyretic ulcer, laryngopharynx swelling and pain, medicine, alimentary toxicosis; Mitigation medicine is strong, toxicity.
The present invention is the characteristics of incidence of inventor in conjunction with duck hemorrhagic necrotic hepatitis, follows meridian tropism principle, use medicine coordinate mutually into usefulness, drink and add a few herbs material, in addition rational proportion, the large prescription of composition multi-flavor medicine.Pharmacological action of the present invention is as follows:
1, antiviral: Herba Artemisiae Scopariae, Fructus Gardeniae, Flos Lonicerae, Venenum Bufonis, Radix Isatidis, Fructus Forsythiae, Radix Glycyrrhizae etc., all have antivirus action.
Radix Isatidis: enter cardiopulmonary warp, there is heat-clearing and toxic substances removing, antiviral effect, research shows, Radix Isatidis is inhibited to cells of coxsackie B 3 virus, mumps virus, herpes simplex virus, influenza virus and hepatitis virus, meanwhile, the growth of immune system organs and the maturation of immunocyte and antiinflammatory action can also be strengthened.
Flos Lonicerae: have broad-spectrum antiseptic, antiviral, antitumor, enhancing immunity and antipyretic and anti-inflammatory, function of gallbladder promoting, the multiple pharmacological effect such as to protect the liver.Antipyretic and anti-inflammatory antiviral has this medicine of research display to be used for the treatment of the diseases such as jaundice due to damp-heat, liver and bile stone, lithangiuria, bacteriological infection, and Flos Lonicerae extract has significant hepatoprotective effect to the hepar damnification that carbon tetrachloride causes).
Venenum Bufonis: there is antibacterial, antiviral, increase lymphocyte quantity, improve immunity, antitumor, antiinflammatory, antitussive, relieving asthma, the effect of heart tonifying.Data shows, and Venenum Bufonis can significant immunological enhancement, can make body lymphocyte quantity, T-lymphocyte percentage significantly improves.(Chinese veterinarian's medical magazine, 2nd phase in 2011, Yang Chunlan, Cao Feng, Li Zhenlong, Venenum Bufonis spirit injection is on the impact of chicken lymphocyte immunologic function), make newcastle disease peripheral blood antibody horizontal, periphery blood T lymphocyte conversion, thymus index, bursal index and spleen index have raising in various degree.(Venenum Bufonis Injection to the influence research of newcastle disease vaccine immune effect, Zhao Jiahui etc., Chinese agronomy circular, the 20th phase in 2012).
Fructus Forsythiae: Fructus Forsythiae has antiviral, protects the liver the multi-efficiencies such as antiinflammatory.Extract have anti-coxsackie B 5 virus and Echovirus effect [Dong Jiede, Chen Chenhua, Chou Suying, the experimentation of four kinds of anti-COxsackies of Chinese herbal medicine and Echovirus. Shandong College of Traditional Chinese Medicine's journal, 1993,17 (4): 46.].Embryo Gallus domesticus in vitro tests proves that Fructus Forsythiae also has inhibitory action to Asia influenza A virus, rhinovirus-17 type etc.Fructus Forsythiae 1:1 injection obviously can reduce the serum glutamic pyruvic transminase activity that rat skin lower injection carbon tetrachloride causes to rat skin lower injection and increase, hepatic necrosis and degeneration simultaneously obviously alleviates, the liver glycogen put aside in hepatocyte and rna content major part recovery or close normal, show that Fructus Forsythiae has the anti-liver injury effect (pharmaceutical research of Fructus Forsythiae, Zhang Wei, Zhang Hanming, Guo Meili etc., Chinese Journal of Modern Applied Pharmacy magazine, volume the 1st phase February the 17th in 2000).
2, hepatoprotective, function of gallbladder promoting: Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Trichosanthis, Fructus Forsythiae, Radix Scrophulariae etc., all have liver-protective effect.
Herba Artemisiae Scopariae: clearing away heat-damp and promoting diuresis, jaundice eliminating.Pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating.Herba Artemisiae Scopariae has significant hepatoprotective effect, to Combined hepatitis A and B vaccine, icterohepatitis, has significant curative effect.Have function of gallbladder promoting, promote bile secretion, increase cholic acid and bilirubin are discharged in bile effect (chemical composition of Herba Artemisiae Scopariae and Advance on Pharmacological Activities, Dong Yan, Wang Xinfang, Cui Changjun etc., time precious traditional Chinese medical science traditional Chinese medicines the 19th volume the 4th phase in 2008; Herba Artemisiae Scopariae Tonga taste curative physical property hepatic injury 65 example, Li Baoyi, Lv Xiaofeng, An Chunmian, Chinese experimental pharmacology of Chinese medical formulae magazine, the 19th volume the 20th phase, in October, 2013).Heart coronary flow can be increased, improve microcirculation, and have blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, drive away ascarid and suppress the effect of multiple pathogenic dermatophytes and antibacterial (to thank field, cattle filial piety shell, Liu Zhanbin etc., the pharmacological action of Herba Artemisiae Scopariae and Clinical advances [J]. Heilungkiang Chinese medicine, 2004,4:50).
Fructus Gardeniae: Fructus Gardeniae and principle active component thereof have the effect of hepatic cholagogic, (Fructus Gardeniae Aqueous extracts is observed the treatment of acute liver and hepatotoxic effect to have good protective effect to the hepatic injury of the induction such as carbon tetrachloride, isothiocyanic acid-1-naphthalene ester flavacin, Lin Qingxun, Xu Lieming, Liaoning University of TCM's journal, the 12nd volume the 6th phase in 2010; The effect of Fructus Gardeniae hepatic cholagogic and liver toxicity research thereof, Zhang Haiyan, Wu Weikui.Li Fang etc.Gardenia Yellow is on the impact of carbon tetrachloride hepatic injury mice, and Zhang Dequan, Lv Feijie, platform are built auspicious etc., Chinese experimental pharmacology of Chinese medical formulae magazine, volume the 19th phase October 36 in 2011; Cholagogic Action of Gargenoside experimentation, Sun Xuqun, Zhao new people, Yang Xu, Anhui Chinese Medicine College journal, the 23rd volume the 5th phase in 2004).
Radix Trichosanthis: there is the biologic activity such as induced labor, antitumor, antiviral, antifungal, antiinflammatory, to hepatitis B, jaundice and abnormal liver function, there is good therapeutic effect.Research data shows, Radix Trichosanthis extract can resist the hepatitis B virus (impact that Radix Trichosanthis extract is expressed HepG2.2.15 cell HBsAg and HBeAg effectively in vitro, Chen Jia, Xu Zhaofa, Ou Yanghongtao etc., Central South University's journal (medicine), the 1st phase in 2012).Clinical practice data show, and Radix Trichosanthis can treat hepatitis B, jaundice eliminating (Treated With Trichosanthin chronic hepatitis B, Wu Peitian, Journal of Traditional Chinese Medicine 47 volumes the 9th phase in 2006; The kind subcutaneous ulcer of harnessing the Yellow River of Radix Trichosanthis, Yang Yuan, Journal of Traditional Chinese Medicine 47 volumes the 9th phase in 2006).
Radix Scrophulariae: there is the antiviral effect of antiinflammatory.Sun Kui etc. once reported that in Radix Scrophulariae, Phenylpropanoid Glycosides glycosides caused acute liver injury of rats model to have good protective action to D-Gal, the obvious inhibition hepatocellular apoptosis of Phenylpropanoid Glycosides glycosides in Radix Scrophulariae.
As preferably, according to a kind of Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis of the present invention, wherein, the described method made is: various raw material powder is broken into 80 object powder, is distributed into 100g every bag for use after mix homogeneously.The relevant regulations that the Chinese crude drug that powder meets powder stick in People's Republic of China's veterinary drug allusion quotation veterinary drug guide for use is concocted.
As preferably, according to a kind of Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis of the present invention, wherein, described a kind of using method for the treatment of the Chinese medicine composition of duck hemorrhagic necrotic hepatitis is: spice or mix in drinking-water oral, expects a kind of Chinese medicine composition use for the treatment of duck hemorrhagic necrotic hepatitis described in interpolation one bag of 100g when spice is oral by every 50kg; Add the Chinese medicine composition use of a kind of anti-Novel duck reovirus described in one bag of 100g by every 100kg water when mixing in drinking water.
The present invention has the following advantages:
Product of the present invention has clearing away heat-fire, protects the liver, the effect of hepatoprotective, has good curative effect to the duck hemorrhagic necrotic hepatitis that Novel duck reovirus causes.Clinical practice shows, the application of the present composition can reduce the mortality rate of morbidity duck group greatly, promotes the rehabilitation of morbidity duck, recovers its growth promoter.Current experiment also finds no any untoward reaction.
Detailed description of the invention
Below in conjunction with embodiment, further illustrate content of the present invention.Should be appreciated that enforcement of the present invention is not limited to the following examples, any pro forma accommodation make the present invention and/or change all will fall into scope.
In the present invention, if not refer in particular to, all parts, percentage ratio are unit of weight, and all equipment and raw material etc. all can be buied from market or the industry is conventional.Method in following embodiment, if no special instructions, is the conventional method of this area.
Embodiment 1:
Treat a Chinese medicine composition for duck hemorrhagic necrotic hepatitis, wherein:
Herba Artemisiae Scopariae 15g, Fructus Gardeniae 15g, Flos Lonicerae 10g, Rhizoma Atractylodis Macrocephalae 15g, Venenum Bufonis 2g, Radix Isatidis 10g, Radix Trichosanthis 10g, Fructus Forsythiae 10g, Radix Scrophulariae 15g, Radix Glycyrrhizae 10g.Various raw materials of traditional Chinese medicinal materials is ground into 80 object powder, mix homogeneously, is distributed into 100g/ bag for use.
By every 50kg, using method: spice is oral, expects that interpolation one bag i.e. 100g Chinese medicine composition of the present invention uses, takes 5 days continuously; Add one bag of 100g Chinese medicine composition of the present invention by every 100kg water when mixing in drinking water to use, take 5 days continuously.
Embodiment 2
Treat a Chinese medicine composition for duck hemorrhagic necrotic hepatitis, wherein:
Herba Artemisiae Scopariae 10g, Fructus Gardeniae 10g, Flos Lonicerae 10g, Rhizoma Atractylodis Macrocephalae 10g, Venenum Bufonis 2g, Radix Isatidis 10g, Radix Trichosanthis 10g, Fructus Forsythiae 10g, Radix Scrophulariae 10g, Radix Glycyrrhizae 10g.Various raw materials of traditional Chinese medicinal materials is ground into 80 object powder, mix homogeneously, is distributed into 100g/ bag for use.
By every 50kg, using method: spice is oral, expects that interpolation one bag i.e. 100g Chinese medicine composition of the present invention uses, takes 5 days continuously; Add one bag of 100g Chinese medicine composition of the present invention by every 100kg water when mixing in drinking water to use, take 5 days continuously.
Embodiment 3
Treat a Chinese medicine composition for duck hemorrhagic necrotic hepatitis, wherein:
Herba Artemisiae Scopariae 15g, Fructus Gardeniae 15g, Flos Lonicerae 15g, Rhizoma Atractylodis Macrocephalae 15g, Venenum Bufonis 2g, Radix Isatidis 15g, Radix Trichosanthis 15g, Fructus Forsythiae 15g, Radix Scrophulariae 15g, Radix Glycyrrhizae 15g.Various raw materials of traditional Chinese medicinal materials is ground into 80 object powder, mix homogeneously, is distributed into 100g/ bag for use.
Using method: spice or mix in drinking-water oral, expects interpolation one bag of 100g Chinese medicine composition use of the present invention by every 50kg when spice is oral, takes 5 days continuously; Add one bag of 100g Chinese medicine composition of the present invention by every 100kg water when mixing in drinking water to use, take 5 days continuously.
Embodiment 4
Treat a Chinese medicine composition for duck hemorrhagic necrotic hepatitis, wherein:
Herba Artemisiae Scopariae 15g, Fructus Gardeniae 15g, Flos Lonicerae 15g, Rhizoma Atractylodis Macrocephalae 10g, Venenum Bufonis 1g, Radix Isatidis 15g, Radix Trichosanthis 18g, Fructus Forsythiae 12g, Radix Scrophulariae 15g, Radix Glycyrrhizae 10g.Various raw materials of traditional Chinese medicinal materials is ground into 80 object powder, mix homogeneously, is distributed into 100g/ bag for use.
Using method: spice or mix in drinking-water oral, expects interpolation one bag of 100g Chinese medicine composition use of the present invention by every 50kg when spice is oral, takes 5 days continuously; Add one bag of 100g Chinese medicine composition of the present invention by every 100kg water when mixing in drinking water to use, take 5 days continuously.
Comparative example 1: spleen invigorating nourishing the liver is fallen apart group
Radix Codonopsis 15g, Rhizoma Atractylodis Macrocephalae 10g, Poria 10g, Fructus Aurantii 10g, Radix Paeoniae Alba 10g, Radix Salviae Miltiorrhizae 10g, Fructus Schisandrae Chinensis 10g, Fructus Crataegi 10g, each 10g of Bulbus Lilii, Rhizoma Dioscoreae 20g, Semen Coicis 20g, Pericarpium Citri Reticulatae 6g, Radix Glycyrrhizae Preparata 6g.Various raw materials of traditional Chinese medicinal materials is ground into 80 object powder, mix homogeneously is for use.
Using method: every 100g spleen invigorating nourishing the liver is fallen apart spice 50kg, takes 5 days continuously.
Comparative example 2: Antiphlogistic Powder of Schizonepetae and Ledebouriellae group
Herba Schizonepetae 45g, Radix Saposhnikoviae 30g, Rhizoma Et Radix Notopterygii 25g, Radix Angelicae Pubescentis 25g, Radix Bupleuri 30g, Radix Peucedani 25g, Fructus Aurantii 30g, Poria 45g, Radix Platycodonis 30g, Rhizoma Chuanxiong 25g, Radix Glycyrrhizae 15g, Herba Menthae 15g.Various raw materials of traditional Chinese medicinal materials is ground into 80 object powder, mix homogeneously is for use.
Using method: every 100g Antiphlogistic Powder of Schizonepetae and Ledebouriellae spice 50kg, takes 5 days continuously.
Comparative example 3: blank group
Any medicine is not used to treat.
Experimental example
Description of test: buy 1 age in days reovirus negative antibody test Muscovy duck, uses project team of the present invention to be separated and the local isolated strain of the same duck source hemorrhagic necrotic hepatitis identified carries out counteracting toxic substances.After counteracting toxic substances 2 days, test example 1-4 used the medicine of embodiment 1-4 to treat at random, and comparative example 1 applies the loose treatment of spleen invigorating nourishing the liver, and comparative example 2 applies Antiphlogistic Powder of Schizonepetae and Ledebouriellae treatment, and comparative example 3, as blank, does not use any medicine to treat.After one week, test statistics the results are shown in following table:
| Experiment group | Laboratory animal number | Survival number | Survival rate (%) |
| Test example 1 | 15 | 14 | 93.3 |
| Test example 2 | 15 | 13 | 86.7 |
| Test example 3 | 15 | 14 | 93.3 |
| Test example 4 | 15 | 15 | 100％ |
| Comparative example 1 | 15 | 9 | 60 |
| Comparative example 2 | 15 | 10 | 66.7 |
| Comparative example 3 | 15 | 8 | 53.3 |
According to above table, prove a kind of development for the treatment of the good Bleeding control hepatitis sequestrans state of an illness of Chinese medicine composition energy of duck hemorrhagic necrotic hepatitis of the present invention, realize effectively treating, infected duck group was got well and growth promoter in the short time.
Clinical practice example
The described a kind of Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis provided in formula of the present invention, clinical practice shows that therapeutic effect does not have obvious difference, below application examples be all described a kind of Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis prepared by the embodiment 1-4 got arbitrarily.
Application examples 1
Experiment duck field 1:
Basic condition: 6 age in days Muscovy duck, there is down in spirits in group's quantity 1250 plumage, feed intake declines, the fragmentary phenomena of mortality, mortality rate 0.8% time medical.
Diagnosis: cut open inspection and laboratory diagnosis be duck hemorrhagic necrotic hepatitis.
Therapeutic Method: every 50kg feedstuff adds the Chinese medicine composition of 100g treatment of the present invention duck hemorrhagic necrotic hepatitis, is used in conjunction 5.
Result: the death of morbidity duck is controlled, and feed intake is recovered gradually, and after one week, general mortality rate is 1.0%.
Application examples 2
Experiment duck field 2:
Basic condition: 5 age in days Muscovy duck, there is down in spirits in group's quantity 200 plumage, feed intake declines, the fragmentary phenomena of mortality, mortality rate 3% time medical.
Diagnosis: cut open inspection and laboratory diagnosis be duck hemorrhagic necrotic hepatitis.
Therapeutic Method: every 50kg feedstuff adds the Chinese medicine composition of 100g treatment of the present invention duck hemorrhagic necrotic hepatitis, is used in conjunction 5.
Result: the death of morbidity duck is controlled, and feed intake is recovered gradually, and after one week, general mortality rate is 4%.
Application examples 3
Experiment duck field 3:
Basic condition: 8 age in days Mule duck, there is down in spirits in group's quantity 400 plumage, feed intake declines, the fragmentary phenomena of mortality, mortality rate 2.5% time medical.
Diagnosis: cut open inspection and laboratory diagnosis be duck hemorrhagic necrotic hepatitis.
Therapeutic Method: every 50kg feedstuff adds the Chinese medicine composition of 100g treatment of the present invention duck hemorrhagic necrotic hepatitis, is used in conjunction 5.
Result: the death of morbidity duck is controlled, and feed intake is recovered gradually, and mortality rate was 3.25% in the 7th day.
Application comparison example 1 spleen invigorating nourishing the liver is fallen apart group
A group:
8 age in days Muscovy duck, there is down in spirits in group's quantity 1000 plumage, feed intake declines, the fragmentary phenomena of mortality, mortality rate 0.8% time medical, diagnosis: cut open inspection and laboratory diagnosis is duck hemorrhagic necrotic hepatitis.Use spleen invigorating nourishing the liver to fall apart 100g spice 50kg, take 5 days continuously, within the 7th day, statistics mortality rate is 42%.
B group:
7 age in days Muscovy duck, there is down in spirits in group's quantity 350 plumage, feed intake declines, the fragmentary phenomena of mortality, mortality rate 0.6% time medical, diagnosis: cut open inspection and laboratory diagnosis is duck hemorrhagic necrotic hepatitis.Use spleen invigorating nourishing the liver to fall apart 100g spice 50kg, take 5 days continuously, within the 7th day, statistics mortality rate is 28.6%.
Application comparison example 2 Antiphlogistic Powder of Schizonepetae and Ledebouriellae group
A group:
8 age in days Muscovy duck, there is down in spirits in group's quantity 380 plumage, feed intake declines, the fragmentary phenomena of mortality, mortality rate 5.3% time medical, diagnosis: cut open inspection and laboratory diagnosis is duck " hemorrhagic necrotic hepatitis ".Use Antiphlogistic Powder of Schizonepetae and Ledebouriellae 100g spice 50kg, take 5 days continuously, within the 7th day, statistics mortality rate is 10.5%.
B group:
13 age in days Muscovy duck, there is down in spirits in group's quantity 100 plumage, feed intake declines, the fragmentary phenomena of mortality, mortality rate 10% time medical, diagnosis: cut open inspection and laboratory diagnosis is duck hemorrhagic necrotic hepatitis.Use Antiphlogistic Powder of Schizonepetae and Ledebouriellae 100g spice 50kg, take 5 days continuously, within the 7th day, statistics mortality rate is 17%.
Application comparison example 3 blank group
I group
10 age in days Muscovy duck, group's quantity 70 plumage, mortality rate 14.3% time medical, diagnosis: cut open inspection and laboratory diagnosis is duck hemorrhagic necrotic hepatitis.Do not take any process, the 7th day as a result statistics, mortality rate 92.8%.Survival duckling growth promoter is seriously obstructed.
II group
5 age in days Muscovy duck, group's quantity 110 plumage, mortality rate 1.8% time medical, does not take any process, the 7th day as a result statistics, mortality rate 90.9%, diagnosis: cut open inspection and laboratory diagnosis is duck hemorrhagic necrotic hepatitis.Survival duckling growth promoter is seriously obstructed.
Claims (3)
1. treat a Chinese medicine composition for duck hemorrhagic necrotic hepatitis, it is characterized in that being made up of the raw material of following weight:
Herba Artemisiae Scopariae 10-15g, Fructus Gardeniae 10-15g, Flos Lonicerae 10-15g, Rhizoma Atractylodis Macrocephalae 10-15g, Venenum Bufonis 1-2g, Radix Isatidis 10-15g, Radix Trichosanthis 10-18g, Fructus Forsythiae 10-12g, Radix Scrophulariae 10-15g, Radix Glycyrrhizae 10-15g.
2. a kind of Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis according to claim 1, is characterized in that, the described method made is: various raw material powder is broken into 80 object powder, is distributed into 100g every bag for use after mix homogeneously.
3. a kind of Chinese medicine composition for the treatment of duck hemorrhagic necrotic hepatitis according to claim 1, it is characterized in that, the using method of the Chinese medicine composition of described treatment duck hemorrhagic necrotic hepatitis is: spice or mix in drinking-water oral, expects that interpolation one bag of 100g treats the Chinese medicine composition use of duck hemorrhagic necrotic hepatitis when spice is oral by every 50kg; Add by every 100kg water the Chinese medicine composition use that one bag of 100g treats duck hemorrhagic necrotic hepatitis when mixing in drinking water.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664465A (en) * | 2009-08-21 | 2010-03-10 | 天津生机集团股份有限公司 | Traditional Chinese herbal medicine powder for preventing and treating duck virus hepatitis and preparation method thereof |
| CN102716232A (en) * | 2012-06-28 | 2012-10-10 | 天津生机集团股份有限公司 | Chinese medicinal composition for preventing and controlling duck virus hepatitis and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664465A (en) * | 2009-08-21 | 2010-03-10 | 天津生机集团股份有限公司 | Traditional Chinese herbal medicine powder for preventing and treating duck virus hepatitis and preparation method thereof |
| CN102716232A (en) * | 2012-06-28 | 2012-10-10 | 天津生机集团股份有限公司 | Chinese medicinal composition for preventing and controlling duck virus hepatitis and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 刘美荣: "一例雏半番鸭疑似新型鸭呼肠孤病毒病的诊治", 《畜禽业》 * |
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