CN104622844A - Capsule skin of chewable soft capsules with immunity enhancing function and soft capsules prepared from capsule skin - Google Patents
Capsule skin of chewable soft capsules with immunity enhancing function and soft capsules prepared from capsule skin Download PDFInfo
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Abstract
The invention discloses capsule skin of chewable soft capsules with immunity enhancing function and soft capsules prepared from the capsule skin. The capsule skin disclosed by the invention is prepared from gelatin, glycerin, purified water, a sweetener, a natural flavouring agent and beta-glucan according to a mass ratio of (25-35) : (10-20) : (25-35) : (5-15) : (0.5-3) : (0.5-5). The preparation process of the capsule skin comprises the following steps: firstly dissolving the flavouring agent in the purified water, mixing with the beta-glucan, carrying out an ultrasonic treatment, mixing the beta-glucan solution with the rest components after the ultrasonic treatment, dissolving, melting the gelatin to obtain a gelatin solution, and preparing the gelatin solution into the capsule skin via a conventional process. By adopting the formula of the capsule skin disclosed by the invention, the capsule skin prepared by the preparation method has high chewiness, stability and moisture retention property, the ultrasonic treatment can balance the rubber smell and the content taste and can exert the immunity enhancing function of the beta-glucan, chewable soft capsules prepared from the capsule skin have good softness, chewiness and taste, after the capsule skin is broken, the capsule skin can be quickly dissolved or dispersed, thereby being easy to swallow.
Description
Technical field
The present invention relates to a kind of capsule shell of masticatory pattern soft capsule, specifically a kind of have the capsule shell of masticatory pattern soft capsule and soft capsule prepared therefrom that strengthen immune effect, belongs to medicine or food or health food or galenic pharmacy technical field.
Background technology
Masticatory pattern soft capsule is a kind of soft capsule that can chew, and compared with traditional capsule preparations, masticatory pattern soft capsule has good chewiness, is easy to take receive old people, child and have be difficult to liking of the patient swallowed to traditional soft capsule.
Along with the development of technology, masticatory pattern soft capsule is also drawn close to field of health care products gradually, is applied in multiple field.There is following deficiency in existing soft capsule and preparation thereof: (1) chewiness is unsatisfactory, and less stable; At present mainly by increasing its Chewiness to adding plasticizer, polymer modifiers and water in formula, such as, US Patent No. 6280767 discloses a kind of chewable soft capsule, this soft capsule makes capsule keep certain pliability by the consumption increasing plasticizer, wherein gelatin in rubber prescription: plasticizer=100:100 ~ 600; US Patent No. 20050136104 discloses a kind of chewable soft capsule, this soft capsule by keeping the higher moisture pliability that makes capsule keep certain, wherein in rubber water content up to 27%; Patent WO2011014942 discloses a kind of chewable soft capsule, and this soft capsule makes capsule shell keep certain pliability and lock aqueous by adding 10-20% starch in rubber, makes rubber be easy to chew; Though above-mentioned technology can obtain certain improvement in its Chewiness, rubber pliability, soft capsule also can be caused to be out of shape because mutually extruding or to bond simultaneously, thus affect the shelf life of product; (2) mouthfeel is not good; Due to the abnormal smells from the patient of rubber itself, content accounts for 60 ~ 90% of granulate capsules weight in addition, the bad smell of some raw materials in content, the mouthfeel that can greatly affect when people take.ZL200910088218.6, ZL00806658.2, ZL200480021784.0 improve the mouthfeel of rubber and content respectively, but when chewing, the mouthfeel distribution of rubber and content is very uneven; CN 101444300 B, CN 101810336 the chewable soft capsule that provides of B with CN 102813275 A be all make the rubber of the relative common soft capsule of rubber have certain chewiness by certain rubber recipe ratio, but mouthfeel regulates only by sweeting agent and essence material, and sweeting agent taste effect is single, the essence material sense of taste of essence material especially chemosynthesis is complicated, local flavor is pure not, and the overall mouthfeel of soft capsule is not good.
Beta glucan is a kind of polysaccharide, usually be present in the cell wall of the antibacterial of Special Category, yeast, fungus (Ganoderma), can activated macrophage, neutrophils etc., thus improve the content of leukin, the basic element of cell division and distinct antibodies, the immune system of comprehensive stimulation body, plays anticancer effect.At present, beta glucan has been widely used in the industry such as health care of food, beauty and skin care.In prior art, beta glucan is mainly applied to the preparation process of soft capsule as wetting agent, and it has the effect improving immunity and fails to be applied fully.
Summary of the invention
The object of the invention is to solve the deficiencies in the prior art, there is provided a kind of and there is the capsule shell of the masticatory pattern soft capsule strengthening immune effect and soft capsule prepared therefrom, this capsule shell formula contains beta glucan, in conjunction with supersound process, both can play moisturizing, stablize, increase the effect of rubber stability, balance rubber abnormal smells from the patient and content mouthfeel, the effect strengthening immunity can also have been played; The masticatory pattern soft capsule prepared with this capsule shell has good pliability, chewiness and mouthfeel, and after soft capsules rupture, capsule shell is rapidly dissolvable or disperse, easy-to-swallow.
Technical solution of the present invention is as follows: a kind of capsule shell with the masticatory pattern soft capsule strengthening immune effect, be by gelatin, glycerol, purified water, sweeting agent, natural flavouring, beta glucan, the quality proportioning of above-mentioned each component is gelatin: glycerol: purified water: sweeting agent: natural flavouring: beta glucan=25 ~ 35:10 ~ 20:25 ~ 35:5 ~ 15:0.5 ~ 3:0.5 ~ 5; Its preparation method is following concrete steps:
(1) natural flavouring is dissolved in the purified water of purified water consumption 10 ~ 20%, mix homogeneously, is heated to 30 ~ 32 DEG C, add beta glucan, continue stirring 5 ~ 15min, being then placed in frequency is supersound process 15 ~ 30mim under the ultrasound wave of 50 ~ 60KHz, obtains beta glucan solution;
(2) setting glue tank jacket temperature 65 DEG C adds transconversion into heat glue tank, by glycerol, remaining purified water, adding of sweeting agent glue tank, stirs 15 ~ 25min and is all uniformly dissolved to material, add beta glucan solution, continue stirring 5 ~ 10min;
(3) reaching 55 DEG C ~ 65 DEG C when changing the temperature of charge in glue tank, by adding of gelatin glue tank under Keep agitation, stopping stirring after continuing stirring 20 ~ 35min, evacuation, after stirring 20 ~ 35min, then stop stirring, after keeping vacuum 30min, stop;
(4) adjustmentization glue tank temperature is 60 DEG C, leaves standstill 2 ~ 5 hours, checks that glue leaves standstill to glue leaving no air bubbles inside, obtained glue;
(5) pressing of capsule shell routine is adopted to obtain the capsule shell with the masticatory pattern soft capsule strengthening immune effect with obtained glue.
Described gelatin is the animal gelatin freezing power scope 80-220; Described animal gelatin can be the combination of one or more obtained by animal skeleton or leather in animal gelatin.
Preferably, described beta glucan preferred molecular weight is the beta glucan of 5 ~ 1000kD.
Preferably, described sweeting agent can be one or more in fructose, sucralose, xylitol, glucose, stevioside, maltose alcohol.
Described natural flavouring can be fruit powder or its combination of single kind.
Described natural flavouring is natural fruity flavor, natural fruit flavors and/or fruit extract.
Described natural flavouring is the combination of one or more in Fructus Citri sinensis powder, Fructus Fragariae Ananssae powder, blue berry powder, apple powder, black currant powder.
Adopt masticatory pattern soft capsule prepared by capsule shell of the present invention, be made up of capsule shell and capsule 's content, its preparation method adopts following concrete steps:
(1) get the obtained glue of the technical scheme prepared according to above-mentioned capsule shell and capsule 's content, with pellet processing machine compacting soft capsule, control sprinkler body temperature in the process of compacting soft capsule: 35 DEG C ~ 50 DEG C; Soft capsule sample detection soft capsule sealing situation and loading amount is extracted at interval of 0.5 ~ 1h during compacting soft capsule; Wherein, described capsule 's content is liquid or semi-solid medicine or health food or food;
(2) soft capsule suppressed is placed in the dry 10 ~ 30h of drying machine rotating cage, then temperature 15 ~ 30 DEG C, under relative humidity 15 ~ 40% condition, static dry 24 ~ 48h, namely obtains.
The beneficial effect that the present invention adopts above-mentioned technical solution to reach is:
(1) soft capsule skin of the present invention in the preparation, not adopt traditional mode jointly mixed by all raw materials, but first natural flavouring is first dissolved in purified water, jointly mix with beta glucan, the viscosity of beta glucan aqueous solution (beta glucan aqueous solution in an acidic solution viscosity is relatively large) fully can be induced by the acidity of fruit powder solution, thus improve the thickening effect of beta glucan in rubber, be more conducive to the chewiness mouthfeel promoting rubber; Glucosan further after supersound process makes its molecular structure loose, and rubber pliability is increased, and supersound process also can expose more can binding end, makes the protein in beta glucan and gelatin obtain better combination, increases the stability of rubber; By supersound process, each component combines tightr, makes formed capsule shell self have good chewiness, and each component can be merged, the abnormal smells from the patient of balance rubber self and content mouthfeel;
(2) beta glucan joins in formula, utilizes its water swellability, makes rubber be easy to dissolve, also plays moisture-keeping function with the viscoelasticity of stable rubber and chewiness mouthfeel to rubber simultaneously; In addition, beta glucan, by supersound process, also can play the effect that it increases immunity;
(3) natural flavouring is selected to adopt fruit powder can utilize its water absorption, plays collaborative moisturizing and promotes that soft capsule skin dissolves the effect of spreading, be beneficial to taking convenience with beta glucan is composite;
(4) in the present invention, the capsule shell of soft capsule also has formula composition novelty, and the full solid of rubber mouthfeel, has the feature of chewiness and joyful mouthfeel concurrently, can improve the acceptance of consumer greatly.
Detailed description of the invention
Embodiment 1 prepares a kind of capsule shell with the masticatory pattern soft capsule strengthening immune effect by the component of following quality proportioning: the gelatin freezing power 150: glycerol: purified water: sweeting agent (fructose): natural flavouring (Fructus Mali pumilae extract): beta glucan (molecular weight 50kD)=30:15:30:10:1:1:
(1) be dissolved in by natural flavouring in the purified water of purified water consumption 15%, mix homogeneously, be heated to 30 ~ 32 DEG C, add beta glucan, continue to stir 10min, being then placed in frequency is supersound process 15mim under the ultrasound wave of 60KHz, obtains beta glucan solution;
(2) setting glue tank jacket temperature 65 DEG C adds transconversion into heat glue tank, by glycerol, remaining purified water, adding of sweeting agent glue tank, opens electric stirring 25min and is all uniformly dissolved to material, add beta glucan solution, continue to stir 10min;
(3) reaching 55 DEG C when changing the temperature of charge in glue tank, by adding of gelatin glue tank under Keep agitation, stopping stirring after stirring 35min, evacuation, after continuing to stir 20min, then stop stirring, after keeping vacuum 30min, stop;
(4) adjustmentization glue tank temperature is 60 DEG C, leaves standstill 3 hours, checks that glue leaves standstill to glue leaving no air bubbles inside, obtained glue;
(5) pressing of capsule shell routine is adopted to obtain the capsule shell with the masticatory pattern soft capsule strengthening immune effect with obtained glue.
Embodiment 2 prepares a kind of capsule shell with the masticatory pattern soft capsule strengthening immune effect by the component of following quality proportioning: the gelatin freezing power 200: glycerol: purified water: sweeting agent (stevioside): natural flavouring (blue berry powder, black currant powder): beta glucan (molecular weight 1000kD)=25:20:25:11:1.8:0.5:
(1) be dissolved in by natural flavouring in the purified water of purified water consumption 20%, mix homogeneously, be heated to 30 ~ 32 DEG C, add beta glucan, continue to stir 5min, being then placed in frequency is supersound process 22mim under the ultrasound wave of 55KHz, obtains beta glucan solution;
(2) setting glue tank jacket temperature 65 DEG C adds transconversion into heat glue tank, by glycerol, remaining purified water, adding of sweeting agent glue tank, stirs 15min and is all uniformly dissolved to material, add beta glucan solution, continue to stir 10min;
(3) reaching 60 DEG C when changing the temperature of charge in glue tank, by adding of gelatin glue tank under Keep agitation, stopping stirring after stirring 20min, evacuation, after continuing to stir 20min, then stop stirring, after keeping vacuum 30min, stop;
(4) adjustmentization glue tank temperature is 60 DEG C, leaves standstill 4 hours, checks that glue leaves standstill to glue leaving no air bubbles inside, obtained glue;
(5) pressing of capsule shell routine is adopted to obtain the capsule shell with the masticatory pattern soft capsule strengthening immune effect with obtained glue.
The preparation of embodiment 3 masticatory pattern soft capsule
1, capsule shell preparation: prepared by the component of following quality proportioning: the gelatin freezing power 80: glycerol: purified water: sweeting agent (xylitol): natural flavouring (Fructus Citri sinensis powder): beta glucan (molecular weight 500kD)=35:10:35:5:0.5:2.5:
(1) be dissolved in by natural flavouring in the purified water of purified water consumption 18%, mix homogeneously, be heated to 30 ~ 32 DEG C, add beta glucan, continue to stir 8min, being then placed in frequency is supersound process 20mim under the ultrasound wave of 55KHz, obtains beta glucan solution;
(2) setting glue tank jacket temperature 65 DEG C adds transconversion into heat glue tank, by glycerol, remaining purified water, adding of sweeting agent glue tank, stirs 20min and is all uniformly dissolved to material, add beta glucan solution, continue to stir 5min;
(3) reaching 65 DEG C when changing the temperature of charge in glue tank, by adding of gelatin glue tank under Keep agitation, stopping stirring after stirring 30min, evacuation, after continuing to stir 20min, then stop stirring, after keeping vacuum 30min, stop;
(4) adjustmentization glue tank temperature is 60 DEG C, leaves standstill 2 hours, checks that glue leaves standstill to glue leaving no air bubbles inside, obtained glue;
2, soft capsule preparation:
(1) get glue and preprepared food liquid as soft capsule content, with pellet processing machine compacting soft capsule, control sprinkler body temperature in the process of compacting soft capsule: 35 DEG C ~ 50 DEG C; Soft capsule sample detection soft capsule sealing situation and loading amount is extracted at interval of 0.5 ~ 1h during compacting soft capsule;
(2) soft capsule suppressed is placed in the dry 10h of drying machine rotating cage, temperature 25 ± 3 DEG C, under relative humidity 30 ~ 40% condition, static dry 48h, namely obtains.
The preparation of embodiment 4 masticatory pattern soft capsule
1, capsule shell preparation: prepared by the component of following quality proportioning: the gelatin freezing power 100: glycerol: purified water: sweeting agent (xylitol, maltose alcohol): natural flavouring (Fructus Fragariae Ananssae extract): beta glucan (molecular weight 5kD)=33:18:26:13:3:5:
(1) be dissolved in by natural flavouring in the purified water of purified water consumption 10%, mix homogeneously, be heated to 30 ~ 32 DEG C, add beta glucan, continue to stir 15min, being then placed in frequency is supersound process 30mim under the ultrasound wave of 50KHz, obtains beta glucan solution;
(2) setting glue tank jacket temperature 65 DEG C adds transconversion into heat glue tank, by glycerol, remaining purified water, adding of sweeting agent glue tank, stirs 22min and is all uniformly dissolved to material, add beta glucan solution, continue to stir 8min;
(3) reaching 55 DEG C when changing the temperature of charge in glue tank, by adding of gelatin glue tank under Keep agitation, stopping stirring after stirring 25min, evacuation, after continuing to stir 20min, then stop stirring, after keeping vacuum 30min, stop;
(4) adjustmentization glue tank temperature is 60 DEG C, leaves standstill 5 hours, checks that glue leaves standstill to glue leaving no air bubbles inside, obtained glue;
2, soft capsule preparation:
(1) get glue and preprepared food liquid as soft capsule content, with pellet processing machine compacting soft capsule, control sprinkler body temperature in the process of compacting soft capsule: 35 DEG C ~ 50 DEG C; Soft capsule sample detection soft capsule sealing situation and loading amount is extracted at interval of 0.5 ~ 1h during compacting soft capsule;
(2) soft capsule suppressed is placed in the dry 24h of drying machine rotating cage, temperature 30 ± 3 DEG C, under relative humidity 30 ~ 40% condition, static dry 26h, namely obtains.
The preparation of embodiment 5 masticatory pattern soft capsule
1, capsule shell preparation: prepared by the component of following quality proportioning: the gelatin freezing power scope 100: glycerol: purified water: sweeting agent (sucralose, fructose): natural flavouring (Fructus Fragariae Ananssae extract): beta glucan (molecular weight 100kD)=33:18:26:13:3:2.5:
(1) natural flavouring (Fructus Fragariae Ananssae extract) is dissolved in the purified water of purified water consumption 15%, mix homogeneously, is heated to 30 ~ 32 DEG C, add beta glucan, continue to stir 10min, being then placed in frequency is supersound process 25mim under the ultrasound wave of 55KHz, obtains beta glucan solution;
(2) setting glue tank jacket temperature 65 DEG C adds transconversion into heat glue tank, by glycerol, remaining purified water, adding of sweeting agent glue tank, stirs 20min and is all uniformly dissolved to material, add beta glucan solution, continue to stir 8min;
(3) reaching 55 DEG C when changing the temperature of charge in glue tank, by adding of gelatin glue tank under Keep agitation, stopping stirring after stirring 20min, evacuation, after continuing to stir 15min, then stop stirring, after keeping vacuum 30min, stop;
(4) adjustmentization glue tank temperature is 60 DEG C, leaves standstill 3.5 hours, checks that glue leaves standstill to glue leaving no air bubbles inside, obtained glue;
2, soft capsule preparation:
(1) get glue and preprepared semisolid health food as soft capsule content, with pellet processing machine compacting soft capsule, control sprinkler body temperature in the process of compacting soft capsule: 35 DEG C ~ 50 DEG C; Soft capsule sample detection soft capsule sealing situation and loading amount is extracted at interval of 0.5 ~ 1h during compacting soft capsule;
(2) soft capsule suppressed is placed in the dry 30h of drying machine rotating cage, temperature 30 ± 3 DEG C, under relative humidity 30 ~ 40% condition, static dry 24h, namely obtains.
The evaluation of embodiment 6 soft capsule: by the preparation method of embodiment 3, embodiment 4, soft capsule sample 1# and sample 2# is obtained using food liquid as content, make comparisons with commercially available soft capsule sample 3#, the sample 4# containing identical content thing simultaneously, take to 20 experimental subjecies in four kinds of samples and evaluate the chewiness of obtained soft capsule, abnormal smells from the patient, mouthfeel, result is as following table; Result shows, soft capsule of the present invention has better chewiness, mouthfeel is good, and joyful being easy to of abnormal smells from the patient accepts.
By sample 1 ~ 4# temperature 35 ~ 36 DEG C, under the equivalent environment of humidity 80%, carry out trimestral shelf-life test, monitor the Qualification of its sense organ and physics and chemistry, microbiological indicator every 15 days.Contrast finds, the soft capsule of the present embodiment can extend the shelf life, and result is as shown in the table.
Claims (8)
1. one kind has the capsule shell of the masticatory pattern soft capsule strengthening immune effect, it is characterized in that: be prepared by gelatin, glycerol, purified water, sweeting agent, natural flavouring, beta glucan, the quality proportioning of above-mentioned each component is gelatin: glycerol: purified water: sweeting agent: natural flavouring: beta glucan=25 ~ 35:10 ~ 20:25 ~ 35:5 ~ 15:0.5 ~ 3:0.5 ~ 5; Its preparation method is following concrete steps:
(1) natural flavouring is dissolved in the purified water of purified water consumption 10 ~ 20%, mix homogeneously, is heated to 30 ~ 32 DEG C, add beta glucan, continue stirring 5 ~ 15min, being then placed in frequency is supersound process 15 ~ 30mim under the ultrasound wave of 50 ~ 60KHz, obtains beta glucan solution;
(2) setting glue tank jacket temperature 65 DEG C adds transconversion into heat glue tank, by glycerol, remaining purified water, adding of sweeting agent glue tank, stirs 15 ~ 25min and is all uniformly dissolved to material, add beta glucan solution, continue stirring 5 ~ 10min;
(3) reaching 55 DEG C ~ 65 DEG C when changing the temperature of charge in glue tank, by adding of gelatin glue tank under Keep agitation, stopping stirring after stirring 20 ~ 35min, evacuation, taking out after continuing stirring 20 ~ 35min, then stopping stirring, after keeping vacuum 30min, stopping;
(4) adjustmentization glue tank temperature is 60 DEG C, leaves standstill 2 ~ 5 hours, checks that glue leaves standstill to glue leaving no air bubbles inside, obtained glue;
(5) pressing of capsule shell routine is adopted to obtain the capsule shell with the masticatory pattern soft capsule strengthening immune effect with obtained glue.
2. capsule shell as claimed in claim 1, is characterized in that: the molecular weight of described beta glucan is 5 ~ 1000kD.
3. capsule shell as claimed in claim 1, is characterized in that: described gelatin is the animal gelatin freezing power scope 80-220; Described animal gelatin is the combination of one or more obtained by animal skeleton or leather in animal gelatin.
4. capsule shell as claimed in claim 1, is characterized in that: described sweeting agent is one or more in fructose, sucralose, xylitol, glucose, stevioside, maltose alcohol.
5. capsule shell as claimed in claim 1, is characterized in that: described natural flavouring is fruit powder or its combination of single kind.
6. capsule shell as claimed in claim 1, is characterized in that: described natural flavouring is natural fruity flavor, natural fruit flavors and/or fruit extract.
7. capsule shell as claimed in claim 1, is characterized in that: described natural flavouring is the combination of one or more in Fructus Citri sinensis powder, Fructus Fragariae Ananssae powder, blue berry powder, apple powder, black currant powder.
8. the masticatory pattern soft capsule prepared of capsule shell according to claim 1, it is characterized in that: be made up of capsule shell and capsule 's content, its preparation method adopts following concrete steps:
(1) get the obtained glue of the technical scheme prepared according to above-mentioned capsule shell and capsule 's content, with pellet processing machine compacting soft capsule, control sprinkler body temperature in the process of compacting soft capsule: 35 DEG C ~ 50 DEG C; Soft capsule sample detection soft capsule sealing situation and loading amount is extracted at interval of 0.5 ~ 1h during compacting soft capsule; Wherein, described capsule 's content is liquid or semi-solid medicine or health food or food;
(2) soft capsule suppressed is placed in the dry 10 ~ 30h of drying machine rotating cage, then temperature 15 ~ 30 DEG C, under relative humidity 15 ~ 40% condition, static dry 24 ~ 48h, namely obtains.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107343651A (en) * | 2017-06-22 | 2017-11-14 | 宜都宏济科技有限公司 | A kind of chewing type soft capsule replenished the calcium and preparation method thereof |
| CN108498480A (en) * | 2018-06-01 | 2018-09-07 | 江苏康缘阳光药业有限公司 | Prevented in Chinese medicinal soft capsule sol-process gelatin congeal power reduction process |
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| CN110150703B (en) * | 2019-05-13 | 2021-08-31 | 广州普正生物科技有限公司 | Anti-adhesion chewing soft capsule shell and preparation method thereof |
| CN113447356A (en) * | 2021-07-12 | 2021-09-28 | 广州白云山星群(药业)股份有限公司 | Method and equipment for testing mechanical properties of soft capsule shell |
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