CN104622844B - A kind of capsule skin with the masticatory pattern soft capsule for strengthening immune effect and soft capsule prepared therefrom - Google Patents
A kind of capsule skin with the masticatory pattern soft capsule for strengthening immune effect and soft capsule prepared therefrom Download PDFInfo
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Abstract
Capsule skin and soft capsule prepared therefrom the invention discloses a kind of masticatory pattern soft capsule for having and strengthening immune effect.Capsule skin of the present invention is by quality proportioning 25 ~ 35 by gelatin, glycerine, purified water, sweetener, natural flavouring, beta glucan:10~20:25~35:5~15:0.5~3:0.5 ~ 5 prepares；During preparation, first flavor enhancement is dissolved in purified water again with beta glucan blending, supersound process, then the beta glucan solution after ultrasound is mixed with remaining component, through dissolving, changing glue, glue is made, then capsule skin is made using common process with the glue.Using the formula of capsule skin of the present invention, the capsule leatherware obtained by the preparation method has higher chewiness, stability, moisture retention, supersound process can also balance rubber smell and content mouthfeel, and play the enhancing immune effect of beta glucan, there is good pliability, chewiness and mouthfeel with the standby masticatory pattern soft capsule of the capsule leather, after soft capsules rupture, capsule skin is rapidly dissolvable or scattered, easy-to-swallow.
Description
Technical field
The present invention relates to a kind of capsule skin of masticatory pattern soft capsule, is specifically a kind of masticatory pattern with enhancing immune effect
The capsule skin and soft capsule prepared therefrom of soft capsule, belong to medicine or food or health food or galenic pharmacy technical field.
Background technology
Masticatory pattern soft capsule is a kind of soft capsule that can be chewed, compared with traditional capsule preparations, masticatory pattern soft capsule
With good chewiness, it is easy to take to receive the elderly, child and have and is difficult to the happiness of patient swallowed to traditional soft capsule
Vigorously.
With the development of technology, masticatory pattern soft capsule is also gradually drawn close to field of health care products, is applied in multiple fields.It is existing
Soft capsule and its preparation there are following deficiency：（1）Chewiness is unsatisfactory, and stability is poor；It is presently mainly logical
Cross to adding plasticizer, polymer modifiers and water in formula to increase its Chewiness, for example, United States Patent (USP)
US6280767 discloses a kind of chewable soft capsule, which makes capsule keep certain soft by increasing the dosage of plasticizer
Gelatin in softness, wherein rubber prescription：Plasticizer=100：100~600；United States Patent (USP) US20050136104 discloses one kind
Chewable soft capsule, the soft capsule is by keeping higher moisture capsule is kept certain pliability, wherein in rubber
Water content is up to 27%；Patent WO2011014942 discloses a kind of chewable soft capsule, and the soft capsule in rubber by adding
10-20% starch makes capsule skin keep certain pliability and water lock so that rubber is easy to chew；Though above-mentioned technology can be at it
Certain improvement is obtained on Chewiness, rubber pliability, but also results in soft capsule at the same time and deforms or glue because mutually extruding
Knot, so as to influence the shelf life of product；（2）Mouthfeel is bad；Due to the smell of rubber in itself, content accounts for whole grain capsule in addition
The 60~90% of weight, the bad smell of some raw materials, can largely effect on mouthfeel when people take in content.
ZL200910088218.6, ZL00806658.2, ZL200480021784.0 respectively carry out the mouthfeel of rubber and content
The distribution of the mouthfeel of rubber and content is very uneven when improving, but chewing；CN 101444300 B, CN 101810336 B and
The chewable soft capsule that 102813275 A of CN are provided all is by certain relatively common flexible glue of rubber recipe ratio rubber
The rubber of capsule has certain chewiness, but mouthfeel is adjusted only by sweetener and essence material, and sweetener taste effect is single,
The essence material sense of taste of essence material especially chemical synthesis is complicated, and flavor is not pure enough, and soft capsule entirety mouthfeel is bad.
Beta glucan is a kind of polysaccharide, is typically found in bacterium, saccharomycete, the fungi of Special Category（Ganoderma lucidum）Cell membrane
In, can activated macrophage, neutrophils etc., so as to improve containing for leukin, the basic element of cell division and distinct antibodies
The effect of measuring, stimulating the immune system of body comprehensively, play anticancer.At present, beta glucan has been widely used in food guarantor
The industries such as strong, beauty and skin care.In the prior art, beta glucan is applied to the preparation process of soft capsule primarily as moisturizer,
There is the effect for improving and being immunized to fail sufficiently to be applied for it.
The content of the invention
It is an object of the invention to solve the deficiencies in the prior art, there is provided a kind of masticatory pattern with enhancing immune effect is soft
The capsule skin and soft capsule prepared therefrom of capsule, the capsule skin formula contain beta glucan, with reference to supersound process, can both rise
To the effect of moisturizing, stabilization, increase rubber stability, balance rubber smell and content mouthfeel, additionally it is possible to it is immune to play enhancing
The effect of；There is good pliability, chewiness and mouthfeel, soft capsules rupture with the standby masticatory pattern soft capsule of the capsule leather
Afterwards, capsule skin is rapidly dissolvable or scattered, easy-to-swallow.
Technical solution of the present invention is as follows：A kind of capsule skin with the masticatory pattern soft capsule for strengthening immune effect, is by bright
Glue, glycerine, purified water, sweetener, natural flavouring, beta glucan, the quality proportioning of above-mentioned each component is gelatin:Glycerine:It is pure
Change water:Sweetener:Natural flavouring:Beta glucan=25 ~ 35:10~20:25~35:5~15:0.5~3:0.5~5；Its preparation method
For following specific steps：
（1）Natural flavouring is dissolved in the purified water of purifying water consumption 10 ~ 20%, is uniformly mixed, is heated to 30 ~ 32
DEG C, add beta glucan, continue 5 ~ 15min of stirring, be subsequently placed in frequency be 50 ~ 60KHz ultrasonic wave under be ultrasonically treated 15 ~
30mim, obtains beta glucan solution；
（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization
Glue tank, 15 ~ 25min of stirring are uniformly dissolved to material, add beta glucan solution, continue 5 ~ 10min of stirring；
（3）When the temperature of charge changed in glue tank reaches 55 DEG C ~ 65 DEG C, by gelatin additionizations glue tank, continuation under lasting stirring
Stop stirring after stirring 20 ~ 35min, vacuumize, after stirring 20 ~ 35min, then stop stirring, after keeping vacuum 30min, stop；
（4）Adjustingization glue tank temperature is 60 DEG C, when standing 2 ~ 5 is small, checks that glue is stood to glue leaving no air bubbles inside, is made
Glue；
（5）The masticatory pattern soft capsule with enhancing immune effect is made using the pressing of capsule skin routine so that glue is made
Capsule skin.
The gelatin is the animal gelatin for freezing power scope 80-220；The animal gelatin can be by animal skeleton or leather
Obtain one or more of combinations in animal gelatin.
Preferably, the beta glucan preferred molecular weight is the beta glucan of 5 ~ 1000kD.
Preferably, the sweetener can be crystal diabetin, Sucralose, xylitol, glucose, steviol glycoside, malt
One or more in sugar alcohol.
The natural flavouring can be fruit powder or its combination of single kind.
The natural flavouring is natural fruity flavor, natural fruit flavors and/or fruit extract.
The natural flavouring is sweet orange powder, one or more of in strawberry powder, blueberry powder, apple powder, blackcurrant powder
Combination.
Using the standby masticatory pattern soft capsule of capsule leather of the present invention, it is made of capsule skin and capsule 's content, its
Preparation method uses following specific steps：
（1）Take according to glue and capsule 's content made from the standby technical solution of above-mentioned capsule leather, suppressed with pellet processing machine
Soft capsule, sprinkler body temperature is controlled during suppressing soft capsule：35℃~50℃；Taken out during suppressing soft capsule at interval of 0.5 ~ 1h
Take soft capsule sample detection soft capsule sealing situation and loading amount；Wherein, the capsule 's content is the medicine of liquid or semisolid
Product or health food or food；
（2）The soft capsule suppressed is placed in drying machine rotating cage dry 10 ~ 30h, then in 15 ~ 30 DEG C of temperature, relatively
Static 24 ~ 48h of drying under the conditions of humidity 15 ~ 40%, that is, be made.
The beneficial effect that the present invention can be reached using above-mentioned technical solution is：
（1）The present invention soft capsule skin in the preparation, be not using it is traditional all raw materials are mixed jointly by the way of, and
It is that first natural flavouring is first dissolved in purified water, is mixed jointly with beta glucan, can be abundant by the acidity of fruit powder solution
Induce the viscosity of beta glucan aqueous solution（Viscosity is relatively large in an acidic solution for beta glucan aqueous solution）, gather so as to improve β Portugals
Thickening effect of the sugar in rubber, is more advantageous to the chewiness mouthfeel of lifting rubber；Glucan after being further ultrasonically treated
So that its molecular structure is loose so that the increase of rubber pliability, supersound process can also expose more can binding end so that β Portugals
Glycan is more preferably combined with the protein in gelatin, increases the stability of rubber；By being ultrasonically treated, each component combines more
Closely so that the capsule skin formed itself has good chewiness, and can be merged each component, and balance rubber is certainly
The smell and content mouthfeel of body；
（2）Beta glucan is added in formula, utilizes its water swellability so that and rubber is easy to dissolve, while also to rubber
Moisture-keeping function is played to stablize the viscoplasticity of rubber and chewiness mouthfeel；In addition, beta glucan can also be played by being ultrasonically treated
It increases immune effect；
（3）Natural flavouring selection can utilize its water imbibition using fruit powder, played with beta glucan compounding and cooperate with moisturizing and rush
Into the effect of soft capsule skin dissolving diffusion, beneficial to convenient to take；
（4）The capsule skin of soft capsule also has formula composition novelty in the present invention, and the full solid of rubber mouthfeel, has chewing concurrently
Property and the characteristics of pleasant mouthfeel, can greatly improve the acceptance of consumer.
Embodiment
Embodiment 1 prepares a kind of masticatory pattern soft capsule with enhancing immune effect by the component of following quality proportioning
Capsule skin：Freeze the gelatin of power 150:Glycerine:Purified water:Sweetener（Crystal diabetin）:Natural flavouring（Apple extract）:β-Portugal
Glycan（Molecular weight 50kD）=30:15:30:10:1:1：
（1）Natural flavouring is dissolved in the purified water of purifying water consumption 15%, is uniformly mixed, is heated to 30 ~ 32 DEG C,
Beta glucan is added, continues to stir 10min, is subsequently placed under the ultrasonic wave that frequency is 60KHz and is ultrasonically treated 15mim, obtain β-Portugal
Glycan solution；
（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization
Glue tank, opens electric stirring 25min and is uniformly dissolved to material, add beta glucan solution, continues to stir 10min；
（3）When the temperature of charge changed in glue tank reaches 55 DEG C, by gelatin additionizations glue tank, stirring 35min under lasting stirring
Stop stirring afterwards, vacuumize, continue after stirring 20min, then stop stirring, after keeping vacuum 30min, stop；
（4）Adjustingization glue tank temperature is 60 DEG C, when standing 3 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made
Liquid；
（5）The masticatory pattern soft capsule with enhancing immune effect is made using the pressing of capsule skin routine so that glue is made
Capsule skin.
Embodiment 2 prepares a kind of masticatory pattern soft capsule with enhancing immune effect by the component of following quality proportioning
Capsule skin：Freeze the gelatin of power 200:Glycerine:Purified water:Sweetener（Steviol glycoside）:Natural flavouring（Blueberry powder, blackcurrant
Powder）:Beta glucan（Molecular weight 1000kD）=25:20:25:11:1.8:0.5：
（1）Natural flavouring is dissolved in the purified water of purifying water consumption 20%, is uniformly mixed, is heated to 30 ~ 32 DEG C,
Beta glucan is added, continues to stir 5min, is subsequently placed under the ultrasonic wave that frequency is 55KHz and is ultrasonically treated 22mim, obtain β-Portugal and gather
Sugar juice；
（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization
Glue tank, stirring 15min are uniformly dissolved to material, add beta glucan solution, continue to stir 10min；
（3）When the temperature of charge changed in glue tank reaches 60 DEG C, by gelatin additionizations glue tank, stirring 20min under lasting stirring
Stop stirring afterwards, vacuumize, continue after stirring 20min, then stop stirring, after keeping vacuum 30min, stop；
（4）Adjustingization glue tank temperature is 60 DEG C, when standing 4 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made
Liquid；
（5）The masticatory pattern soft capsule with enhancing immune effect is made using the pressing of capsule skin routine so that glue is made
Capsule skin.
The preparation of 3 masticatory pattern soft capsule of embodiment
1st, capsule leather is standby：Prepared by the component of following quality proportioning：Freeze the gelatin of power 80:Glycerine:Purified water:Sweetener
（Xylitol）:Natural flavouring（Sweet orange powder）:Beta glucan（Molecular weight 500kD）=35:10:35:5:0.5:2.5：
（1）Natural flavouring is dissolved in the purified water of purifying water consumption 18%, is uniformly mixed, is heated to 30 ~ 32 DEG C,
Beta glucan is added, continues to stir 8min, is subsequently placed under the ultrasonic wave that frequency is 55KHz and is ultrasonically treated 20mim, obtain β-Portugal and gather
Sugar juice；
（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization
Glue tank, stirring 20min are uniformly dissolved to material, add beta glucan solution, continue to stir 5min；
（3）When the temperature of charge changed in glue tank reaches 65 DEG C, by gelatin additionizations glue tank, stirring 30min under lasting stirring
Stop stirring afterwards, vacuumize, continue after stirring 20min, then stop stirring, after keeping vacuum 30min, stop；
（4）Adjustingization glue tank temperature is 60 DEG C, when standing 2 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made
Liquid；
2nd, prepared by soft capsule：
（1）Glue and preprepared food liquid is taken to suppress soft capsule, pressure as soft capsule content with pellet processing machine
Sprinkler body temperature is controlled during soft capsule processed：35℃~50℃；During suppressing soft capsule soft capsule sample is extracted at interval of 0.5 ~ 1h
Soft capsule sealing situation and loading amount are surveyed in product examine；
（2）The soft capsule suppressed is placed in drying machine rotating cage dry 10h, in 25 ± 3 DEG C of temperature, relative humidity 30 ~
Static dry 48h under the conditions of 40%, that is, be made.
The preparation of 4 masticatory pattern soft capsule of embodiment
1st, capsule leather is standby：Prepared by the component of following quality proportioning：Freeze the gelatin of power 100:Glycerine:Purified water:Sweet taste
Agent（Xylitol, maltitol）:Natural flavouring（Fragaia ananassa Duchesne extract）:Beta glucan（Molecular weight 5kD）=33:18:26:13:3:
5：
（1）Natural flavouring is dissolved in the purified water of purifying water consumption 10%, is uniformly mixed, is heated to 30 ~ 32 DEG C,
Beta glucan is added, continues to stir 15min, is subsequently placed under the ultrasonic wave that frequency is 50KHz and is ultrasonically treated 30mim, obtain β-Portugal
Glycan solution；
（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization
Glue tank, stirring 22min are uniformly dissolved to material, add beta glucan solution, continue to stir 8min；
（3）When the temperature of charge changed in glue tank reaches 55 DEG C, by gelatin additionizations glue tank, stirring 25min under lasting stirring
Stop stirring afterwards, vacuumize, continue after stirring 20min, then stop stirring, after keeping vacuum 30min, stop；
（4）Adjustingization glue tank temperature is 60 DEG C, when standing 5 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made
Liquid；
2nd, prepared by soft capsule：
（1）Glue and preprepared food liquid is taken to suppress soft capsule, pressure as soft capsule content with pellet processing machine
Sprinkler body temperature is controlled during soft capsule processed：35℃~50℃；During suppressing soft capsule soft capsule sample is extracted at interval of 0.5 ~ 1h
Soft capsule sealing situation and loading amount are surveyed in product examine；
（2）The soft capsule suppressed is placed in drying machine rotating cage dry 24h, in 30 ± 3 DEG C of temperature, relative humidity 30 ~
Static dry 26h under the conditions of 40%, that is, be made.
The preparation of 5 masticatory pattern soft capsule of embodiment
1st, capsule leather is standby：Prepared by the component of following quality proportioning：Freeze the gelatin of power scope 100:Glycerine:Purified water:
Sweetener（Sucralose, crystal diabetin）:Natural flavouring（Fragaia ananassa Duchesne extract）:Beta glucan（Molecular weight 100kD）=33:18:
26:13:3:2.5：
（1）By natural flavouring（Fragaia ananassa Duchesne extract）It is dissolved in the purified water of purifying water consumption 15%, is uniformly mixed, adds
Heat adds beta glucan to 30 ~ 32 DEG C, continues to stir 10min, is subsequently placed under the ultrasonic wave that frequency is 55KHz and is ultrasonically treated
25mim, obtains beta glucan solution；
（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization
Glue tank, stirring 20min are uniformly dissolved to material, add beta glucan solution, continue to stir 8min；
（3）When the temperature of charge changed in glue tank reaches 55 DEG C, by gelatin additionizations glue tank, stirring 20min under lasting stirring
Stop stirring afterwards, vacuumize, continue after stirring 15min, then stop stirring, after keeping vacuum 30min, stop；
（4）Adjustingization glue tank temperature is 60 DEG C, when standing 3.5 is small, checks that glue is stood to glue leaving no air bubbles inside, is made
Glue；
2nd, prepared by soft capsule：
（1）Glue and preprepared semisolid health food is taken to be suppressed as soft capsule content with pellet processing machine soft
Capsule, sprinkler body temperature is controlled during suppressing soft capsule：35℃~50℃；Extracted during suppressing soft capsule at interval of 0.5 ~ 1h
Soft capsule sample detection soft capsule seals situation and loading amount；
（2）The soft capsule suppressed is placed in drying machine rotating cage dry 30h, in 30 ± 3 DEG C of temperature, relative humidity 30 ~
Static dry 24h under the conditions of 40%, that is, be made.
The evaluation of 6 soft capsule of embodiment：By embodiment 3, the preparation method of embodiment 4, content is used as using food liquid
Soft capsule sample 1# and sample 2# is made, while is made comparisons with commercially available soft capsule sample 3#, sample 4# containing identical content,
Four kinds of samples are taken to 20 experimental subjects and chewiness, smell, mouthfeel to soft capsule is made are evaluated, it is as a result as follows
Table；The result shows that soft capsule of the invention has, more preferably chewiness, mouthfeel is good, and smell pleasure is easy to receive.
By 1 ~ 4# of sample at 35 ~ 36 DEG C of temperature, the identical environment of humidity 80%, trimestral shelf-life experiment is carried out, often
Its sense organ and physics and chemistry, the Qualification of microbiological indicator were monitored every 15 days.Contrast finds that the soft capsule of the present embodiment can extend guarantor
It is the matter phase, as a result as shown in the table.
Claims (5)
- A kind of 1. capsule skin with the masticatory pattern soft capsule for strengthening immune effect, it is characterised in that：By following quality proportioning It is prepared by component：Freeze the gelatin of power 150:Glycerine:Purified water:Sweetener crystal diabetin:Natural flavouring apple extract:Molecule Measure beta glucan=30 of 50kD:15:30:10:1:1：（1）Natural flavouring is dissolved in the purified water of purifying water consumption 15%, be uniformly mixed, be heated to 30 ~ 32 DEG C, added Beta glucan, continues to stir 10min, is subsequently placed under the ultrasonic wave that frequency is 60KHz and is ultrasonically treated 15min, obtains beta glucan Solution；（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization glue tank, Open electric stirring 25min to be uniformly dissolved to material, add beta glucan solution, continue to stir 10min；（3）When the temperature of charge changed in glue tank reaches 55 DEG C, by gelatin additionizations glue tank under lasting stirring, stop after stirring 35min Only stir, vacuumize, continue after stirring 20min, then stop stirring, after keeping vacuum 30min, stop；（4）Adjustingization glue tank temperature is 60 DEG C, when standing 3 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made；（5）The glue of the masticatory pattern soft capsule with enhancing immune effect is made so that glue is made using the pressing of capsule skin routine Capsule skin.
- A kind of 2. capsule skin with the masticatory pattern soft capsule for strengthening immune effect, it is characterised in that：By following quality proportioning It is prepared by component：Freeze the gelatin of power 200:Glycerine:Purified water:Sweetener steviol glycoside:Natural flavouring blueberry powder, blackcurrant powder: Beta glucan=25 of molecular weight 1000kD:20:25:11:1.8:0.5：（1）Natural flavouring is dissolved in the purified water of purifying water consumption 20%, be uniformly mixed, be heated to 30 ~ 32 DEG C, added Beta glucan, continues to stir 5min, is subsequently placed under the ultrasonic wave that frequency is 55KHz and is ultrasonically treated 22min, obtains beta glucan Solution；（2）65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization glue tank, Stirring 15min is uniformly dissolved to material, adds beta glucan solution, continues to stir 10min；（3）When the temperature of charge changed in glue tank reaches 60 DEG C, by gelatin additionizations glue tank under lasting stirring, stop after stirring 20min Only stir, vacuumize, continue after stirring 20min, then stop stirring, after keeping vacuum 30min, stop；（4）Adjustingization glue tank temperature is 60 DEG C, when standing 4 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made；（5）The glue of the masticatory pattern soft capsule with enhancing immune effect is made so that glue is made using the pressing of capsule skin routine Capsule skin.
- A kind of 3. masticatory pattern soft capsule with enhancing immune effect, it is characterised in that：Using following steps：（1）Capsule skin is prepared by the component of following quality proportioning：Freeze the gelatin of power 80:Glycerine:Purified water:Sweetener xylitol: Natural flavouring sweet orange powder:Beta glucan=35 of molecular weight 500kD:10:35:5:0.5:2.5：1. natural flavouring is dissolved in the purified water of purifying water consumption 18%, is uniformly mixed, is heated to 30 ~ 32 DEG C, add β- Glucan, continues to stir 8min, is subsequently placed under the ultrasonic wave that frequency is 55KHz and is ultrasonically treated 20min, it is molten to obtain beta glucan Liquid；2. 65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization glue tank, Stirring 20min is uniformly dissolved to material, adds beta glucan solution, continues to stir 5min；3. when the temperature of charge changed in glue tank reaches 65 DEG C, by gelatin additionizations glue tank under lasting stirring, stop after stirring 30min Stirring, vacuumizes, and continues after stirring 20min, then stops stirring, and after keeping vacuum 30min, stops；4. adjustingization glue tank temperature is 60 DEG C, when standing 2 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made；（2）It is prepared by soft capsule：1. glue and preprepared food liquid is taken to be suppressed as soft capsule content with pellet processing machine Soft capsule, sprinkler body temperature is controlled during suppressing soft capsule：35℃~50℃；Taken out during suppressing soft capsule at interval of 0.5 ~ 1h Take soft capsule sample detection soft capsule sealing situation and loading amount；2. the soft capsule suppressed is placed in drying machine rotating cage dry 10h, the static dry 48h under the conditions of 25 ± 3 DEG C of temperature, relative humidity 30 ~ 40%, that is, be made.
- A kind of 4. masticatory pattern soft capsule with enhancing immune effect, it is characterised in that：Using following steps：（1）Capsule skin is prepared by the component of following quality proportioning：Freeze the gelatin of power 100:Glycerine:Purified water:Sweetener xylitol, Maltitol:Natural flavouring Fragaia ananassa Duchesne extract:Beta glucan=33 of molecular weight 5kD:18:26:13:3:5：1. natural flavouring is dissolved in the purified water of purifying water consumption 10%, is uniformly mixed, is heated to 30 ~ 32 DEG C, add β- Glucan, continues to stir 15min, is subsequently placed under the ultrasonic wave that frequency is 50KHz and is ultrasonically treated 30min, it is molten to obtain beta glucan Liquid；2. 65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization glue tank, Stirring 22min is uniformly dissolved to material, adds beta glucan solution, continues to stir 8min；3. when the temperature of charge changed in glue tank reaches 55 DEG C, by gelatin additionizations glue tank under lasting stirring, stop after stirring 25min Stirring, vacuumizes, and continues after stirring 20min, then stops stirring, and after keeping vacuum 30min, stops；4. adjustingization glue tank temperature is 60 DEG C, when standing 5 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made；（2）It is prepared by soft capsule：1. glue and preprepared food liquid is taken to be suppressed as soft capsule content with pellet processing machine Soft capsule, sprinkler body temperature is controlled during suppressing soft capsule：35℃~50℃；Taken out during suppressing soft capsule at interval of 0.5 ~ 1h Take soft capsule sample detection soft capsule sealing situation and loading amount；2. the soft capsule suppressed is placed in drying machine rotating cage dry 24h, the static dry 26h under the conditions of 30 ± 3 DEG C of temperature, relative humidity 30 ~ 40%, that is, be made.
- A kind of 5. masticatory pattern soft capsule with enhancing immune effect, it is characterised in that：Using following steps：（1）Capsule skin is prepared by the component of following quality proportioning：Freeze the gelatin of power scope 100:Glycerine:Purified water:Sweetener three Chlorine sucrose, crystal diabetin:Natural flavouring Fragaia ananassa Duchesne extract:Beta glucan=33 of molecular weight 100kD:18:26:13:3: 2.5：1. Fragaia ananassa Duchesne extract is dissolved in the purified water of purifying water consumption 15%, is uniformly mixed, is heated to 30 ~ 32 DEG C, add β- Glucan, continues to stir 10min, is subsequently placed under the ultrasonic wave that frequency is 55KHz and is ultrasonically treated 25min, it is molten to obtain beta glucan Liquid；2. 65 DEG C of heatingization glue tanks of settingization glue tank jacket temperature, by glycerine, remaining purified water, sweetener additionization glue tank, Stirring 20min is uniformly dissolved to material, adds beta glucan solution, continues to stir 8min；3. when the temperature of charge changed in glue tank reaches 55 DEG C, by gelatin additionizations glue tank under lasting stirring, stop after stirring 20min Stirring, vacuumizes, and continues after stirring 15min, then stops stirring, and after keeping vacuum 30min, stops；4. adjustingization glue tank temperature is 60 DEG C, when standing 3.5 is small, checks that glue is stood to glue leaving no air bubbles inside, glue is made；（2）It is prepared by soft capsule：1. glue and preprepared semisolid health food are taken as soft capsule content, with pill Machine suppresses soft capsule, and sprinkler body temperature is controlled during suppressing soft capsule：35℃~50℃；At interval of 0.5 during compacting soft capsule ~ 1h extracts soft capsule sample detection soft capsule sealing situation and loading amount；2. the soft capsule suppressed is placed in drying machine rotating cage Dry 30h, the static dry 24h under the conditions of 30 ± 3 DEG C of temperature, relative humidity 30 ~ 40%, that is, be made.
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| CN107343651A (en) * | 2017-06-22 | 2017-11-14 | 宜都宏济科技有限公司 | A kind of chewing type soft capsule replenished the calcium and preparation method thereof |
| CN108498480B (en) * | 2018-06-01 | 2020-11-13 | 江苏康缘阳光药业有限公司 | Process for preventing gelatin freezing force from reducing in traditional Chinese medicine soft capsule sol process |
| CN110150703B (en) * | 2019-05-13 | 2021-08-31 | 广州普正生物科技有限公司 | Anti-adhesion chewing soft capsule shell and preparation method thereof |
| CN113447356B (en) * | 2021-07-12 | 2022-02-18 | 广州白云山星群(药业)股份有限公司 | Method and equipment for testing mechanical properties of soft capsule shell |
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| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| KR20140134937A (en) * | 2013-05-15 | 2014-11-25 | (주)아모레퍼시픽 | Lamella capsule and formation method of the lamella capsule |
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