CN104621154B - A kind of bactericidal composition containing prothioconazoles and benzene metsulfovax and application thereof - Google Patents
A kind of bactericidal composition containing prothioconazoles and benzene metsulfovax and application thereof Download PDFInfo
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- CN104621154B CN104621154B CN201310571678.0A CN201310571678A CN104621154B CN 104621154 B CN104621154 B CN 104621154B CN 201310571678 A CN201310571678 A CN 201310571678A CN 104621154 B CN104621154 B CN 104621154B
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Abstract
The invention discloses a kind of bactericidal composition containing prothioconazoles and benzene metsulfovax and application thereof.This bactericidal composition is with prothioconazoles and benzene metsulfovax for principle active component.This bactericidal composition can be applicable to preventing and treating Cereal, fruit tree, vegetable disease, has higher synergistic function, overcomes and delayed the Drug resistance of pathogenic bacteria, and sterilization speed is fast, lasting period length, reduce application cost, and prevention effect is substantially better than its single dose and uses.The present invention may be used for the fungal disease on preventing and treating crops, being particularly useful for preventing and treating powdery mildew, banded sclerotial blight, droop, leaf spot, rust, sclerotiniose, net blotch, moire disease, gray mold, melasma, brown spot, balck shank, downy mildew, late blight and smut, effect is better than single dose and uses.
Description
Technical field:
The present invention relates to a kind of bactericidal composition and application thereof, particularly to a kind of bactericidal composition containing prothioconazoles and benzene metsulfovax and application thereof.
Background technology:
Prothioconazoles (Prothioconazole), it it is the New-type wide-spectrum triazolinthione series bactericidal agent developed by Beyer Co., Ltd, chemical name: 2-(2-(1-chlorine cyclopropyl)-3-(2-chlorphenyl)-2-hydroxypropyl-1-2-dihydro-3-1,2,4-triazole-3-sulfo-, molecular formula: C14H15Cl2N3OS.Structural formula is as follows:
The mechanism of action of prothioconazoles is to suppress the demethylation effect on the precursor lanosterol of sterol in fungus or the liquor-saturated l4 position of 24-methylene dihydro Mi hair, i.e. demethylation inhibitors (DMIs).Not only there is good systemic activity, excellent protection, treat and root out activity, and the lasting period is long.By substantial amounts of field control effectiveness test, result shows that crop is not only had good safety by prothioconazoles, and preventing disease theraping effect is good, and increases production substantially, compares with triazole type biocide agent, and prothioconazoles has broader spectrum of bactericidal activity.It is mainly used in numerous diseases such as preventing and treating cereal crop such as Semen Tritici aestivi, Fructus Hordei Vulgaris, Brassica campestris L, Semen arachidis hypogaeae, Oryza sativa L. and legume crop.Almost all wheat and barley diseases there is good prevention effect, such as Semen Tritici aestivi and the powdery mildew of Fructus Hordei Vulgaris, banded sclerotial blight, droop, leaf spot, rust, sclerotiniose, net blotch, moire disease etc..Oil Lay and the soil-borne disease of Semen arachidis hypogaeae can also be prevented and treated, such as sclerotiniose, and main foliage disease, such as gray mold, melasma, brown spot, balck shank, sclerotiniose and rust etc..
Benzene metsulfovax (Benthiavalicarb-isopropyl), chemical name: [[(6-fluoro benzothiazole-2-base)-ethylaminocarbonyl]-2-methyl-propyl] carbamic acid isopropyl ester.
Benzene metsulfovax is the new type bactericide one benzene metsulfovax developed jointly by combinatorial chemistry industrial group and Ihara company, phytophthora root rot is had good bactericidal activity, to its sporangial formation, sporangial sprouting, there is good inhibiting effect at low concentrations, but the release of zoospore and the movement of zoospore are not acted on.Field test to Plasmopara viticola, downy mildew of cucurbits bacterium and Cruciferae Pseudoperonospora cubensis, result is similar.The late blight of potato and downy mildew of cucurbits are had bactericidal activity by benzene metsulfovax.
The industrial crops cultivated areas such as the difficulty of prevention and cure of current phytopathogen is increasing, on the one hand, along with the change of pattern of farming, melon fruits and vegetables progressively expand, and disease occurrence degree, occur quantity all to increase, and in preventing and treating, difficulty strengthens；On the other hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the prevention effect of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention:
It is an object of the invention to provide a kind of applied widely, plant bactericide drug compositions containing prothioconazoles and benzene metsulfovax that cost is low, effective for above-mentioned technical problem.
It is a still further object of the present invention to provide a kind of bactericidal composition containing prothioconazoles and benzene metsulfovax and cause the application of fungal disease medicine as preparation preventing and treating plant epiphyte, prevent and treat the application of medicine in powdery mildew, banded sclerotial blight, droop, leaf spot, rust, sclerotiniose, net blotch, moire disease, gray mold, melasma, brown spot, balck shank, downy mildew, smut and late blight especially as preparation.
It is an object of the invention to be realized by following measures:
A kind of bactericidal composition containing prothioconazoles and benzene metsulfovax, wherein prothioconazoles and benzene metsulfovax weight ratio are 1～70:1～50, it is preferred to 1～35:1～25, more preferably 1～10:1～20, it is most preferred that for 1:2～6.
It is 2～80% that both described prothioconazoles and benzene metsulfovax account for the percentage by weight of compositions, it is preferable that 10～40%.
The dosage form that described prothioconazoles and benzene metsulfovax and known auxiliary agent and excipient are re-dubbed on pesticide to allow.These known auxiliary agents have dispersant, diffusant, defoamer, wetting agent, disintegrating agent etc., calcium dodecyl benzene sulfonate can be adopted, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide addition product, polyoxyethylene polyoxy propylene ether, castor oil polyoxyethylene ether, NPE, TWEEN Series, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphite, lignosulfonates, xanthan gum, phenol formaldehyde condensate, ammonium salt, quaternary etc., excipient includes Ketohexamethylene, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as propylene glycol), deionized water etc..Above auxiliary agent, excipient and other adjuvant can be alone or and use.
Described dosage form is cream, wettable powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
The described bactericidal composition containing prothioconazoles and benzene metsulfovax is as the application of preparation preventing and treating resistance plant fungal disease medicine.
The described bactericidal composition containing prothioconazoles and benzene metsulfovax prevents and treats the application of powdery mildew, banded sclerotial blight, droop, leaf spot, rust, sclerotiniose, net blotch, moire disease, gray mold, melasma, brown spot, balck shank and smut medicine as preparation.
Beneficial effects of the present invention:
Bactericidal composition of the present invention is as the application of medicine on preparation preventing and treating resistance plant fungus, and the application preventing and treating powdery mildew, banded sclerotial blight, droop, leaf spot, rust, sclerotiniose, net blotch, moire disease, gray mold, melasma, brown spot, balck shank, downy mildew, late blight and smut medicine especially as preparation all has significant effect.Bactericidal composition of the present invention can produce higher synergistic function, and activity is more than the activity of independent component.
Compared with prior art beneficial effects of the present invention: (1) is compared with single dose, bactericidal composition antagonism fungal disease such as powdery mildew, banded sclerotial blight, droop, leaf spot, rust, sclerotiniose, net blotch, moire disease, gray mold, melasma, brown spot, balck shank, downy mildew, late blight and smut of the present invention have obvious synergistic function, delay Drug resistance, expanding prevention is composed, hence it is evident that improve prevention effect；(2) preventing and treating recruitment, drug cost are reduced；(3) alternative routine and the pesticide being easily generated resistance；(4) compared with single dose, produce and use cost reduces；(5) suppressing the drug-fast generation of fungus, its effect uses apparently higher than its single dose.
Detailed description of the invention:
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of dosage form is conventional method, and " % " of the present invention is mass percent.
Two kinds of reactive compounds can be processed into any one dosage form of permission, with specific embodiment, the preparation that two kinds of effective ingredient are processed into is described below, but the preparation that these two kinds of active component can be processed is not limited only to set forth below.
Embodiment 1:
By prothioconazoles 5g, benzene metsulfovax 10g, detergent LS (to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient weight percentage is 15% wettable powder.
Embodiment 2:
By prothioconazoles 3g, benzene metsulfovax 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient weight percentage is 15% wettable powder.
Embodiment 3:
By prothioconazoles 2g, benzene metsulfovax 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient weight percentage is 14% wettable powder.
Embodiment 4:
Weigh 5g prothioconazoles, 50g benzene metsulfovax, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into the mixing of mixing kettle high speed, and making effective Ingredients Weight percentage composition is 55% prothioconazoles-benzene metsulfovax aqueous emulsion.
Embodiment 5:
Weigh 2g prothioconazoles, 30g benzene metsulfovax, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.The method that above raw material is prepared microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredients Weight percentage composition is 32% prothioconazoles-benzene metsulfovax microemulsion.
Embodiment 6:
Weigh 1g prothioconazoles, 5g benzene metsulfovax, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into the mixing of mixing kettle high speed, and making effective Ingredients Weight percentage composition is 6% prothioconazoles-benzene metsulfovax aqueous emulsion.
Embodiment 7:
Weighing 50g prothioconazoles, 20g benzene metsulfovax, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor oil polyoxyethylene ether 2g, solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredients Weight percentage composition is 70% prothioconazoles-benzene metsulfovax cream.
Embodiment 8:
Weighing 2g prothioconazoles, 40g benzene metsulfovax, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredients Weight percentage composition is 42% prothioconazoles-benzene metsulfovax cream.
Embodiment 9:
Weigh 5g prothioconazoles, 20g benzene metsulfovax, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.The method that above raw material is prepared microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredients Weight percentage composition is 25% prothioconazoles-benzene metsulfovax microemulsion.
Embodiment 10:
Weighing 5g prothioconazoles, 0.5g benzene metsulfovax, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredients Weight percentage composition is 5.5% prothioconazoles-benzene metsulfovax cream.
Embodiment 11:
Weighing 5g prothioconazoles, 30g benzene metsulfovax, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredients Weight percentage composition is 35% prothioconazoles-benzene metsulfovax cream.
Embodiment 12:
Weigh 10g prothioconazoles, 10g benzene metsulfovax, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthan gum 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complementing to 100g with water, making effective Ingredients Weight percentage composition under the effect of sand mill is 20% prothioconazoles-benzene metsulfovax suspending agent.
Embodiment 13:
Weigh 30g prothioconazoles, 12g benzene metsulfovax, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthan gum 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complementing to 100g with water, making effective Ingredients Weight percentage composition under the effect of sand mill is 42% prothioconazoles-benzene metsulfovax suspending agent.
Embodiment 14:
Weigh 2g prothioconazoles, 5g benzene metsulfovax, sodium lignin sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, Borax 2g, white carbon 3g, kieselguhr complement to 100g, and by water dispersible granular agent method, above raw material is formed with effect Ingredients Weight percentage composition is 7% prothioconazoles-benzene metsulfovax water dispersion granule.
Embodiment 15:
Weigh 4g prothioconazoles, 13g benzene metsulfovax, sodium lignin sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, Borax 2g, kieselguhr 28g complements to 100g, and by water dispersible granular agent method, above raw material is formed with effect Ingredients Weight percentage composition is 17% prothioconazoles-benzene metsulfovax water dispersion granule.
Embodiment 16:
Weigh 5g prothioconazoles, 15g benzene metsulfovax, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthan gum 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complementing to 100g with water, making effective Ingredients Weight percentage composition under the effect of sand mill is 20% prothioconazoles-benzene metsulfovax suspending agent.
Field control effectiveness test:
1. test processes: this test medicine sets 3 dosings respectively according to the different proportion of prothioconazoles (A) Yu benzene metsulfovax (B), wherein, dosing is effective ingredient prothioconazoles (A) and effective ingredient benzene metsulfovax (B) quality sum.Comparison medicament is pesticide single dose 15% benzene metsulfovax WP and 5% prothioconazoles ME and blank clean water experiment respectively.
2. test method: each plot area is 66.7m2, repeat 3 times；Investigation drug effect method after investigating before dispenser and preventing and treating is: randomization 5 point in test treatment region, carries out severity Scaling according to country's field test relevant criterion, calculates preventive effect.Result of the test is shown in following table:
Table 1 field control effectiveness test result
, the present composition has obvious synergistic function by field efficacy it is shown that as shown in Table 1, and the prevention effect of compositions is excellent, and prevention effect is all better than single dose kind, has using value in agricultural is applied.
Claims (3)
1. the wettable powder containing prothioconazoles and benzene metsulfovax, it is characterized in that: by prothioconazoles 5g, benzene metsulfovax 10g, to methoxyl group fatty acyl amido benzene sulfonic acid sodium salt 2g, dispersing agent NNO 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient weight percentage is 15% wettable powder.
2. the wettable powder containing prothioconazoles and benzene metsulfovax, it is characterized in that: by prothioconazoles 3g, benzene metsulfovax 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient weight percentage is 15% wettable powder.
3. the wettable powder containing prothioconazoles and benzene metsulfovax, it is characterized in that: by prothioconazoles 2g, benzene metsulfovax 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient weight percentage is 14% wettable powder.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1847176A1 (en) * | 2005-02-04 | 2007-10-24 | Mitsui Chemicals, Inc. | Plant pathogen control composition and method |
| CN102395272A (en) * | 2009-04-15 | 2012-03-28 | 先正达参股股份有限公司 | Fungicidal mixtures |
| CN103392717A (en) * | 2013-07-30 | 2013-11-20 | 海利尔药业集团股份有限公司 | Sterilization composition containing benthiavalicarb isopropyl and prothioconazole |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1847176A1 (en) * | 2005-02-04 | 2007-10-24 | Mitsui Chemicals, Inc. | Plant pathogen control composition and method |
| CN102395272A (en) * | 2009-04-15 | 2012-03-28 | 先正达参股股份有限公司 | Fungicidal mixtures |
| CN103392717A (en) * | 2013-07-30 | 2013-11-20 | 海利尔药业集团股份有限公司 | Sterilization composition containing benthiavalicarb isopropyl and prothioconazole |
Non-Patent Citations (1)
| Title |
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| "新型杀菌剂苯噻菌胺";刘允萍 等;《农药》;20111231;第50卷(第10期);第756-757页 * |
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