CN104619827A - 用于连续灌注的过滤装置 - Google Patents

用于连续灌注的过滤装置 Download PDF

Info

Publication number
CN104619827A
CN104619827A CN201280068431.0A CN201280068431A CN104619827A CN 104619827 A CN104619827 A CN 104619827A CN 201280068431 A CN201280068431 A CN 201280068431A CN 104619827 A CN104619827 A CN 104619827A
Authority
CN
China
Prior art keywords
liquid
filter
container
agitator
shaft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280068431.0A
Other languages
English (en)
Chinese (zh)
Inventor
J·A·卡斯蒂略冈萨雷斯
V·派特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artelis SA
Pall Technology UK Ltd
Original Assignee
Artelis SA
Pall Technology UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artelis SA, Pall Technology UK Ltd filed Critical Artelis SA
Publication of CN104619827A publication Critical patent/CN104619827A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/051—Stirrers characterised by their elements, materials or mechanical properties
    • B01F27/054—Deformable stirrers, e.g. deformed by a centrifugal force applied during operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
    • B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
    • B01F27/91—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with propellers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/42—Mixers with shaking, oscillating, or vibrating mechanisms with pendulum stirrers, i.e. with stirrers suspended so as to oscillate about fixed points or axes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/44—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement
    • B01F31/445—Mixers with shaking, oscillating, or vibrating mechanisms with stirrers performing an oscillatory, vibratory or shaking movement performing an oscillatory movement about an axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4534—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a rod for supporting the stirring element, e.g. stirrer sliding on a rod or mounted on a rod sliding in a tube
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/14—Bags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/26—Constructional details, e.g. recesses, hinges flexible
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/02—Stirrer or mobile mixing elements
    • C12M27/06—Stirrer or mobile mixing elements with horizontal or inclined stirrer shaft or axis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201280068431.0A 2011-12-09 2012-12-07 用于连续灌注的过滤装置 Pending CN104619827A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161568872P 2011-12-09 2011-12-09
US61/568,872 2011-12-09
PCT/US2012/068513 WO2013086371A1 (en) 2011-12-09 2012-12-07 Filtration apparatus for continuous perfusion

Publications (1)

Publication Number Publication Date
CN104619827A true CN104619827A (zh) 2015-05-13

Family

ID=48574930

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280068431.0A Pending CN104619827A (zh) 2011-12-09 2012-12-07 用于连续灌注的过滤装置

Country Status (7)

Country Link
US (1) US20140370588A1 (https=)
EP (1) EP2788468A4 (https=)
JP (1) JP2015500033A (https=)
CN (1) CN104619827A (https=)
CA (1) CA2861519A1 (https=)
SG (1) SG11201402997QA (https=)
WO (1) WO2013086371A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113522132A (zh) * 2021-07-19 2021-10-22 山东农业工程学院 一种农业滴灌用水肥药均混装置
CN113975988A (zh) * 2015-12-29 2022-01-28 生命科技股份有限公司 具有侧向移位的柔性驱动线的流体混合系统及使用方法
US12128371B2 (en) 2012-04-06 2024-10-29 Life Technologies Corporation Fluid mixing system with flexible drive line and foldable impeller
US12460171B2 (en) 2018-01-17 2025-11-04 Life Technologies Corporation Fluid mixing systems including helical mixing assembly with impeller attachment

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9248420B2 (en) * 2013-12-16 2016-02-02 Pall Corporation High turndown impeller
EP2944372A1 (en) * 2014-05-17 2015-11-18 Miltenyi Biotec GmbH Method and device for suspending cells
US10092888B2 (en) 2014-11-07 2018-10-09 Genesis Technologies, Llc Linear reciprocating actuator
US10519409B2 (en) * 2014-12-31 2019-12-31 Ge Healthcare Bio-Sciences Corp. Shaft-mounted fluid transfer assembly for a disposable bioreactor
ITUB20154901A1 (it) * 2015-10-22 2017-04-22 Paolo Gobbi Frattini S R L Nuova sacca per la preparazione di innesti di tessuto adiposo
CN108699502A (zh) * 2016-02-23 2018-10-23 康宁股份有限公司 灌注生物反应器及其用于进行连续细胞培养的方法
FR3141686B1 (fr) * 2022-11-03 2024-12-13 Gary Kane Concept Bouchon pour distributeur d’échantillons fluides.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4184916A (en) * 1977-11-14 1980-01-22 Monsanto Company Continuous cell culture system
US4596779A (en) * 1983-03-23 1986-06-24 Bellco Glass, Inc. Culture vessel with agitator
CN1531589A (zh) * 2001-07-09 2004-09-22 ��������װҩ���˽�˱�����˾ 一次性容器
US20090035856A1 (en) * 2007-07-30 2009-02-05 Xcellerex, Inc. Continuous perfusion bioreactor system
CN101460605A (zh) * 2006-05-13 2009-06-17 高级技术材料公司 一次性生物反应器

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649118A (en) * 1984-04-05 1987-03-10 The Virtis Company, Inc. Cell culturing apparatus with improved stirring and filter means
JPH04252175A (ja) * 1991-01-28 1992-09-08 Teijin Ltd 細胞培養槽
US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
US7249880B2 (en) * 2003-10-14 2007-07-31 Advanced Technology Materials, Inc. Flexible mixing bag for mixing solids, liquids and gases
US7875448B2 (en) * 2004-01-12 2011-01-25 Single Use Brx, Llc Bioreactor systems and disposable bioreactor
EP1940539B1 (de) * 2005-10-03 2010-12-15 Zeta Biopharma GmbH Einweggebinde mit rührer
CN101300338B (zh) * 2005-10-26 2015-10-21 Atmi包装公司 具有混合器和喷射器的生物反应器
US7832922B2 (en) * 2007-11-30 2010-11-16 Levitronix Gmbh Mixing apparatus and container for such
CA2766902C (en) * 2009-07-06 2021-07-06 Genentech, Inc. Method of culturing eukaryotic cells

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4184916A (en) * 1977-11-14 1980-01-22 Monsanto Company Continuous cell culture system
US4596779A (en) * 1983-03-23 1986-06-24 Bellco Glass, Inc. Culture vessel with agitator
CN1531589A (zh) * 2001-07-09 2004-09-22 ��������װҩ���˽�˱�����˾ 一次性容器
CN101460605A (zh) * 2006-05-13 2009-06-17 高级技术材料公司 一次性生物反应器
US20090035856A1 (en) * 2007-07-30 2009-02-05 Xcellerex, Inc. Continuous perfusion bioreactor system

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12128371B2 (en) 2012-04-06 2024-10-29 Life Technologies Corporation Fluid mixing system with flexible drive line and foldable impeller
US12226743B2 (en) 2012-04-06 2025-02-18 Life Technologies Corporation Methods for mixing a fluid with foldable impellers
CN113975988A (zh) * 2015-12-29 2022-01-28 生命科技股份有限公司 具有侧向移位的柔性驱动线的流体混合系统及使用方法
US12077742B2 (en) 2015-12-29 2024-09-03 Life Technologies Corporation Methods for fluid mixing systems with laterally displaced flexible drive lines
US12460171B2 (en) 2018-01-17 2025-11-04 Life Technologies Corporation Fluid mixing systems including helical mixing assembly with impeller attachment
CN113522132A (zh) * 2021-07-19 2021-10-22 山东农业工程学院 一种农业滴灌用水肥药均混装置

Also Published As

Publication number Publication date
JP2015500033A (ja) 2015-01-05
WO2013086371A1 (en) 2013-06-13
EP2788468A1 (en) 2014-10-15
SG11201402997QA (en) 2014-07-30
EP2788468A4 (en) 2015-09-16
US20140370588A1 (en) 2014-12-18
CA2861519A1 (en) 2013-06-13

Similar Documents

Publication Publication Date Title
CN104619827A (zh) 用于连续灌注的过滤装置
CN101300338B (zh) 具有混合器和喷射器的生物反应器
US8602636B2 (en) Eccentrically-rotating reactor
JP6605251B2 (ja) シングルユース細胞培養装置および培養バッグ
JP2004534544A (ja) 使い捨て容器
AU2002346088A1 (en) Disposable vessel
EP3207119A1 (en) Mixing and filtering system and method
JP2021517817A (ja) チャネルを有する折り畳み式バッフルを含む一回使用の容器
WO2014008336A1 (en) Driven fluid mixer and related methods
CN107438478B (zh) 生物处理混合器
JP4561192B2 (ja) 細胞培養装置及び細胞培養方法
JP2018161115A (ja) 細胞培養装置及び細胞培養方法
JP2015000025A (ja) 培養装置および培養方法
KR100915605B1 (ko) 세포 배양장치 및 이를 포함한 세포 배양 시스템
JP6744161B2 (ja) 分離装置、培養装置および分離方法
WO2010063845A1 (en) Liquid substance circulation device comprising a compartment for an impeller having a sloped upper portion
JP2002045173A (ja) 細胞塊の培養方法およびバイオリアクター
JP7292706B2 (ja) 灌流培養システム及び遠心機
US20240367122A1 (en) Hollow shaft impeller
CN116457450A (zh) 具有一体式流体导管的生物处理器皿
HK1069847B (en) Disposable vessel

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20150513

WD01 Invention patent application deemed withdrawn after publication