CN104604877A - Bactericidal composition containing penflufen and boscalid - Google Patents
Bactericidal composition containing penflufen and boscalid Download PDFInfo
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- CN104604877A CN104604877A CN201510073428.3A CN201510073428A CN104604877A CN 104604877 A CN104604877 A CN 104604877A CN 201510073428 A CN201510073428 A CN 201510073428A CN 104604877 A CN104604877 A CN 104604877A
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- boscalid
- fluorine
- bacterium aniline
- bactericidal composition
- azoles bacterium
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Abstract
The invention discloses a bactericidal composition containing penflufen and boscalid. The bactericidal composition comprises effective constituents including the penflufen and boscalid, a commonly agricultural bactericide dosage form is prepared by adding a proper amount of agricultural bactericide auxiliaries. The bactericidal composition has higher prevention and treatment effect on crop fungal diseases, and two medicaments have obvious synergism effect; the medicament amount can be decreased, the ecological damage and environment pollution can be effectively reduced, and the yield and quality of crops can be improved; the penflufen and boscalid are low-toxicity, thus being safe to human and livestock, beneficial organisms and environment; the resistance to fungus of single medicament can be prolonged.
Description
Technical field
The invention belongs to disinfectant use in agriculture field, be specifically related to the bactericidal composition of a kind of fluorine azoles bacterium aniline and Boscalid.
Background technology
The sclerotinia rot of colza that sclerotinite (Sclerotinia sclerotiorum) causes is a kind of very harmful disease on Rape-seed production, in the world, each rape producing region occurs all very serious, the all rape producing regions of China occur there is generation, occur the most serious with the Yangtze river basin and the southeastern coastal areas, incidence of disease 10%-80%, has a strong impact on output and rapeseed quality.At present, the disease caused these two kinds of cause of diseases is main still based on chemical control.But the use of long-term single medicament and irrational insecticide-applying way, make pathogen be easy to develop immunity to drugs, cause drug effect decline, disease outburst, and then strengthen medication, form vicious circle, strengthen drug cost, aggravation environmental pollution, this is also a great problem of chemical control.The agricultural chemicals of the different mechanism of action is rationally composite is that the effective measures with development occur customer service pesticide resistance, and chemical constitution is different, the mechanism of action is close but the agricultural chemicals that preventive effect significantly strengthens, prevention and treatment range expands carries out rationally compositely also can improving performance, reducing the dosage of unit are, improve control efficiency.
Fluorine azoles bacterium aniline (Penflufen) belongs to pyrazole amide series bactericidal agent, and its chemical name is fluoro-1, the 3-dimethyl-1H-pyrazole-4-carboxamide of N-[2-(1,3-dimethylbutyl) phenyl]-5-.Former medicine outward appearance: gray powdery solid; Fusing point: 111 DEG C; Boiling point: decompose before boiling point; Decomposition temperature: 320 DEG C; Vapour pressure: 1.2 × 10-6Pa (25 DEG C); Solvability (25 DEG C): the solvability in water is 10.9mg/L; Solvability in n-hexane is 1.6g/L, is 62g/L in toluene, is 139g/L in acetone, is 126g/L in methyl alcohol, is 96g/L in ethyl acetate, is 162g/L in methyl-sulfoxide.Stability: stable in acidity, alkaline medium, stablizes light.Low toxicity, rat acute per os LD
50> 5000mg/kg, acute through skin LD
50> 2000mg/kg.
Structural formula is shown below:
Fluorine azoles bacterium aniline is the class novel pyrazole acid amide fungicides that development in recent years is got up, and has the effects such as protection, treatment, interior suction, transporting.This bactericide is succinate dehydrogenase (SDH) inhibitor, mainly acts on respiratory chain electron transmission Complex II, blocks energy metabolism.Seed after treatment can absorb fluorine azoles bacterium aniline in germination process, and is transmitted to other positions of plant corpus by xylem, thus plays the effect of cover crop.Can to prevent and treat kind pass, basidiomycetes that soil passes and sac fungi disease, the diseases such as the potato black scurf caused having rhizoctonia and ustilagin etc., wheat sharp eyespot, rice sheath blight disease, sclerotinia rot of colza, loose smut of wheat, the bunt of wheat, corn southern leaf blight have good prevention and control, result for the treatment of.
Boscalid (Boscalid) is a kind of Novel tobacco amide-type systemic fungicide, and its chemical name is the chloro-N-of 2-(4 '-chlorodiphenyl-2-base) vitamin PP.The tasteless crystal of sterling white, fusing point 142.8 DEG C ~ 143.8 DEG C.In 20 DEG C of water, solvability is 4.6mg/L, the solvability (20 DEG C, g/L) in other solvents: normal heptane <10, methyl alcohol: 40 ~ 50, acetone 160 ~ 200.Boscalid is at room temperature stable in air, can place 14d, not photodissociation in water for 54 DEG C.Boscalid belongs to low toxicity bactericide, former medicine rat acute oral LD50 > 5000mg/kg, and rat (male/female) is acute through skin LD50 > 2000mg/kg.
Structural formula is as shown in above formula:
The mechanism of action of Boscalid is succinic acid ubiquinone reductase inhibitor in mitochondrial respiratory chain.Very strong rejection ability is had to the sprouting of spore, and with other bactericide without cross resistance.When using, liquid is permeated by blade face through plant absorption, by the evaporation of moisture in leaf and the flowing of water make liquid transmit be diffused into blade end and leaf margin position, and with the effect of pathogen intracellular mitochondrial.Boscalid fungicidal spectrum is wider, almost there is activity to all types of fungal disease, to preventing and treating, banded sclerotial blight, powdery mildew, gray mold, stalk break and various rots etc. are very effective, and also effective to the resistance bacterium of other medicaments, be mainly used in the control comprising the diseases such as rape, grape, fruit tree, vegetables and field crop.
Summary of the invention
The invention provides the bactericidal composition of a kind of fluorine-containing azoles bacterium aniline and Boscalid, there is bactericidal activity high, delay the drug-fast emergence and development of pathogen, and dosage total in unit are is declined, achieve the object of economy, efficient, environmental protection.
Two classes are possessed the bactericide of different types of structure by the present invention, namely pyrazole amide series bactericidal agent fluorine azoles bacterium aniline and Novel tobacco acid amide fungicides Boscalid combined, and be processed into the upper easy-to-use preparation of production, biologically active is high, dosage total in unit are declines, and reduces dispenser cost, delays pathogen pesticide resistance emergence and development, extend the service life of each component in bactericidal composition, thus realize goal of the invention that is economic, efficient, environmental protection.
A bactericidal composition for fluorine-containing azoles bacterium aniline and Boscalid, is characterized in that: said composition comprises the active ingredient be made up of fluorine azoles bacterium aniline and Boscalid, and described fluorine azoles bacterium aniline and the mass ratio of Boscalid are 1:40 ~ 40:1.
Described fluorine azoles bacterium aniline and the bactericidal composition of Boscalid, is characterized in that: the mass ratio of described fluorine azoles bacterium aniline and Boscalid is: 1:15 ~ 15:1.
Described fluorine-containing azoles bacterium aniline and the bactericidal composition of Boscalid, is characterized in that: this bactericidal composition becomes with Boscalid any one formulation that agricultural chemicals allows by fluorine azoles bacterium aniline with known additive compound.
Described fluorine-containing azoles bacterium aniline and Boscalid bactericidal composition, it is characterized in that: described formulation is suspension seed-coating agent, aqueous suspension agent, wetting powder, microcapsule formulations or water-dispersible granules.
The bactericidal composition of described fluorine-containing azoles bacterium aniline and Boscalid, is characterized in that: in described composition, the active ingredient of fluorine azoles bacterium aniline and Boscalid composition accounts for 5% ~ 90% of bactericidal composition gross mass.
The bactericidal composition of described fluorine-containing azoles bacterium aniline and Boscalid, is characterized in that: the active ingredient of the bacterium aniline of fluorine azoles described in described composition and Boscalid composition accounts for 30% ~ 55% of bactericidal composition gross mass.
The application of bactericidal composition in control crop fungal disease of described fluorine-containing azoles bacterium aniline and Boscalid.
Described agricultural bactericidal agent aid comprises each analog assistants such as film forming agent, pigment, preservative, antifreezing agent, emulsifier, wetting agent, dispersant, thickener, defoamer, filler, and the emulsifier of employing, wetting agent, dispersant can be one or more in sodium dodecyl benzenylsulfonate, sodium butylnaphthalenesulfonate, sodium lignin sulfonate, NP-10, propane diols etc.; The thickener adopted can be xanthans, polyvinyl alcohol etc.; The defoamer adopted to can be in phosphoric acid ester defoamer and silicone defoaming agent one or more; The filler adopted can be in white carbon, kaolin, attapulgite etc. one or more;
The application of described bactericidal composition in control crop fungal disease.
Careful analysis is done to the sterilization idiocratic of fluorine azoles bacterium aniline and Boscalid.First the EC50 (drug safety index) of fluorine azoles bacterium aniline and Boscalid two single compound (hereinafter referred to as medicament) is measured, set the portfolio ratio of two medicaments by Wadley method according to the EC50 of two single medicaments, and according to Wadley coefficient of synergism SR value.
Test objective thing is the sclerotinite causing sclerotinia rot of colza, and field trial have chosen simultaneously and causes the Rhizoctonia solani Kuhn of soybean miliary damping-off to be object, but does not limit so.Get fluorine azoles bacterium aniline and Boscalid, be configured to need liquid dull and stereotyped, every ware is about 15ml.Produce the mycelia block of 5mm diameter at the card punch of preculture colony edge sterilizing, move on on different culture media flat board respectively, 25 DEG C of cultivations.Test adopts mycelial growth determination method, pastille medium is made by different disposal, the mycelia block of 5mm diameter is produced at the card punch of preculture colony edge sterilizing, move on on the different culture medium flat plate of content of dispersion respectively, right-angled intersection method is adopted to measure colony diameter, measure colony diameter (mm), by following formulae discovery growth inhibition ratio:
Mycelial growth inhibition rate %=(1-chemicals treatment colony diameter-5/ contrast colony diameter-5) × 100%
Mycelial growth inhibition rate is converted into and suppresses probit value (Y), drug concentration is converted into log concentration (X), by log concentration be abscissa, probit value is that ordinate makes toxicity regression straight line, try to achieve fluorine azoles bacterium aniline and Boscalid single dose and mixture thereof to the virulence regression equation of germ, and calculate EC
50value and correlation coefficient r value.
According to the interaction of Wadley method evaluation mixture, computing formula is as follows:
EC
50(theoretical value)=(a+b)/(a/EC
50a+b/EC
50b),
SR=EC
50(theoretical value)/EC
50(real value).
Wherein a, b are each component content ratio in mixture, analyze the effect of mixture with SR value.SR≤0.5, then two kinds of medicament mixtures have antagonism; SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition; SR >=1.5, then two kinds of medicament mixtures have synergistic effect.
Table 1 fluorine azoles bacterium aniline and Boscalid single dose and mixture thereof are to sclerotinite toxicity test result
As can be seen from Table 1, the fluorine azoles bacterium aniline of different proportion and Boscalid composition different to causing the sclerotinite fungistatic effect of sclerotinia rot of colza, experimental result shows that it all has addition than being listed in 15:1 to 1:15, have synergistic effect, and synergy is remarkable when 15:1 to 1:1 and 1:10.
The present invention has higher control efficiency to crop fungal disease, there is notable synergistic effect between two components; Can dosage be reduced, effectively reduce ecological disruption and environmental pollution, and crop yield and quality can be improved; In the present invention, fluorine azoles bacterium aniline and Boscalid all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security; The pesticide resistance of germ to single medicament can be delayed.
Embodiment
Below in conjunction with embodiment, the invention will be further described, but essence of the present invention is not limited to following embodiment.
Embodiment 1
The preparation method of 44% fluorine azoles bacterium aniline Boscalid suspending agent: by mass percentage.
Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.Every mu of consumption 50g prevents and treats sclerotinia rot of colza, and preventive effect reaches 91.5%.
Embodiment 2
The preparation method of 48% fluorine azoles bacterium aniline Boscalid suspending agent: by mass percentage.
Preparation method, with embodiment 1.Every mu of consumption 40g prevents and treats sclerotinia rot of colza, and preventive effect reaches 90.7%.
Embodiment 3
The preparation method of 48% fluorine azoles bacterium aniline Boscalid wetting powder: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, add a small amount of purified water after having pulverized and stir, after oven dry wetting powder product.Every mu of consumption 40g prevents and treats sclerotinia rot of colza, and preventive effect reaches 87.3%.
Embodiment 4
The preparation method of 50% fluorine azoles bacterium aniline Boscalid wetting powder: by mass percentage.
Preparation method: with embodiment 3.Every mu of consumption 40g prevents and treats sclerotinia rot of colza, and preventive effect reaches 92.1%.
Embodiment 5
The preparation method of 48% fluorine azoles bacterium aniline Boscalid water dispersible granules: by mass percentage.
Preparation method: above component is added mixer by formula rate and mixes laggard row air-flow crushing, add a small amount of purified water after having pulverized and stir, extruder grain, after oven dry water dispersible granules product.Every mu of consumption 35g prevents and treats sclerotinia rot of colza, and preventive effect reaches 88.4%.
Embodiment 6
The preparation method of 60% fluorine azoles bacterium aniline Boscalid water dispersible granules: by mass percentage.
Preparation method: with embodiment 5.Every mu of consumption 40g prevents and treats sclerotinia rot of colza, and preventive effect reaches 91%.
Embodiment 7
The preparation method of 44% fluorine azoles bacterium aniline Boscalid suspension seed-coating agent: by mass percentage.
Preparation method: according to formula, weighs in proportion by above component, adds ball mill ball milling 60 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspension seed-coating agent product.Carry out dressing seed according to every 100kg seed 300ml suspension seed-coating agent, for preventing and treating soybean miliary damping-off, preventive effect reaches 88.6%.
Embodiment 8
The preparation method of 36% fluorine azoles bacterium aniline Boscalid suspension seed-coating agent: by mass percentage.
Preparation method, with embodiment 7.Carry out dressing seed according to every 100kg seed 300ml suspension seed-coating agent, for preventing and treating soybean miliary damping-off, preventive effect reaches 87.4%.
Finally, it is also to be noted that what enumerate above is only several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, a lot of distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all think protection scope of the present invention.
Claims (7)
1. a bactericidal composition for fluorine-containing azoles bacterium aniline and Boscalid, is characterized in that: said composition comprises the active ingredient be made up of fluorine azoles bacterium aniline and Boscalid, and described fluorine azoles bacterium aniline and the mass ratio of Boscalid are 1:40 ~ 40:1.
2. the bactericidal composition of fluorine azoles bacterium aniline according to claim 1 and Boscalid, is characterized in that: the mass ratio of described fluorine azoles bacterium aniline and Boscalid is: 1:15 ~ 15:1.
3. the bactericidal composition of fluorine-containing azoles bacterium aniline according to claim 1 and Boscalid, is characterized in that: this bactericidal composition becomes with Boscalid any one formulation that agricultural chemicals allows by fluorine azoles bacterium aniline with known additive compound.
4. the bactericidal composition of fluorine-containing azoles bacterium aniline and Boscalid according to claim 3, is characterized in that: described formulation is suspension seed-coating agent, aqueous suspension agent, wetting powder, microcapsule formulations or water-dispersible granules.
5. the bactericidal composition of fluorine-containing azoles bacterium aniline and Boscalid according to claim 1, is characterized in that: in described composition, the active ingredient of fluorine azoles bacterium aniline and Boscalid composition accounts for 5% ~ 90% of bactericidal composition gross mass.
6. the bactericidal composition of fluorine-containing azoles bacterium aniline and Boscalid according to claim 5, is characterized in that: the active ingredient of the bacterium aniline of fluorine azoles described in described composition and Boscalid composition accounts for 30% ~ 55% of bactericidal composition gross mass.
7. the application of bactericidal composition in control crop fungal disease of fluorine-containing azoles bacterium aniline and Boscalid described in any one of claim 1-6.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785462A (en) * | 2003-10-23 | 2010-07-28 | 拜尔农作物科学股份公司 | Synergistic fungicidal active combinations |
| WO2010118946A2 (en) * | 2009-04-15 | 2010-10-21 | Syngenta Participations Ag | Fungicidal mixtures |
| CN104206387A (en) * | 2013-05-30 | 2014-12-17 | 陕西美邦农药有限公司 | Synergy pesticide composition containing penflufen |
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2015
- 2015-02-11 CN CN201510073428.3A patent/CN104604877A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101785462A (en) * | 2003-10-23 | 2010-07-28 | 拜尔农作物科学股份公司 | Synergistic fungicidal active combinations |
| WO2010118946A2 (en) * | 2009-04-15 | 2010-10-21 | Syngenta Participations Ag | Fungicidal mixtures |
| CN104206387A (en) * | 2013-05-30 | 2014-12-17 | 陕西美邦农药有限公司 | Synergy pesticide composition containing penflufen |
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Application publication date: 20150513 |