CN104587418B - A kind of Chinese medicine preparation and preparation method for acute fatty liver of pregnancy - Google Patents

Abstract

The invention discloses a kind of Chinese medicine preparation for acute fatty liver of pregnancy, it is with radix glehniae, oriental wormwood, stir-baked RADIX PAEONIAE ALBA, desmodium, rhizoma atractylodis macrocephalae, hawthorn, Buddha's hand, rhizoma atractylodis, giant knotweed, corydalis tuber, rhizoma cyperi, citron, fiveleaf akebia fruit, Fructus meliae toosendan, the Radix Astragali, root tuber of aromatic turmeric, Caulis Perillae, radix scutellariae, lotus leaf, stir-baked RADIX BUPLEURI with vinegar, Semen Coicis Semen Coicis, licorice is raw material, according to the different qualities of every taste Chinese medicine, after cleaning stripping and slicing pretreatment, prepare in proportion, made through specific process, with dispersing stagnated hepatoqi, hepatic cholagogic, expelling wind and removing dampness, the effect of normalizing gallbladder to cure jaundice, product mix of the present invention and preparation method are unique, according to clinical verification, the medicine therapeutic effect is notable, treatment cycle is short, it is cheap, have no adverse reaction and any toxic side effect, with wide market application foreground.

Description

A kind of Chinese medicine preparation and preparation method for acute fatty liver of pregnancy

Technical field

The present invention relates to a kind of Chinese medicine preparation, and in particular to a kind of Chinese medicine preparation for acute fatty liver of pregnancy, this hair The bright preparation method for further relating to the Chinese medicine preparation.

Background technology

Acute Fatty Liver During Pregnancy（AFLP）Also known as " the acute false yellow atrophy of obstetrics ", " pregnant idiopathic fat Liver ", " gestational period hepatic steatosis " etc..Acute Fatty Liver During Pregnancy is third trimester of pregnancy distinctive mortality Uncommon Diseases.Should Sick onset is hurried, and change of illness state is rapid, can occur, in gestation 28~40 weeks, to be more common in the primiparas of After Gravidity 35 Weeks or so, pregnant Phase high blood pressure disease, twins and male tire are easier to occur.Clinical manifestation is similar to fulminant hepatitis.AFLP etiology unknown.Due to AFLP betides third trimester of pregnancy, and only terminal pregnancy just has the hope of recovery from illness, therefore it is Hormone change caused by gestation to speculate, makes fat Obstacle occurs for fat acid metabolic, causes free fatty to be deposited in the other organs such as liver cell and kidney, pancreas, brain, causes multiple organ damage. Having many cases recurrent cases and its filial generation in recent years has genetic defect report, therefore it has been proposed that is probably inborn genetic disease. In addition, virus infection, poisoning, medicine（Such as tetracycline）, malnutrition, hypertensive disorder in pregnancy etc. it is multifactor to mitochondria fat The detrimental effect of fat acid oxidase may be also associated therewith.Onset only has continuation Nausea and vomiting, weak, epigastric pain or head initial stage Bitterly.There is jaundice in pregnant woman after a couple of days to 1 week, and progressive is deepened, often without itch.Stomachache can be confined to upper right abdomen, also can be in more Dissipate property.Patient often has hypertension, albuminuria, oedema, and a few peoples have transient diuresis and polydipsia, if the state of an illness of not giving a birth continue into , there is coagulation disorders, skin petechiae, ecchymosis, hemorrhage of digestive tract, gingiva bleeding gingival hemorrhage etc., hypoglycemia, the disturbance of consciousness, spirit in exhibition Symptom and hepatic encephalopathy, oliguria, anuria and renal failure, it is often dead in a short time.Early stage has acute severe epigastric pain, Amylase increases, and like acute pancreatitis, though jaundice is obvious, serum bilirubin increases, and urine bilirubin is often negative.Type B excusing from death inspection Look into and increase for fatty liver waveform, lobuli hepatis to middle band cell, fat vacuole, no bulk necrosis of liver cells are full of in endochylema.

The traditional Chinese medical science thinks that the etiology and pathogenesis of fatty liver is mainly that stagnation of liver qi, catharsis are not normal, so that mechanism of qi retardance, perverse and unreasonable manner are violated Stomach, qi disease involving blood, thrombosis and cost disease；When liver disease affecting spleen, the dysfunction of the spleen in transport, water is wet stops over, with the passing of time raw phlegm, so that phlegm wet is handed over Knot, interior strongly fragrant liver and gall and cost disease.

Clinically doctor trained in Western medicine is treated using cortex hormone of aadrenaline or liver protection more at present, and the long-term or short time uses this Class medicine is treated, and can cause obesity, crinosity, oedema, intestine gastric ulcer, orthostatic hypotension, Nausea and vomiting, dizziness, constipation Fetal anomaly and miscarriage etc. a series of side effects symptom are even caused, primary affection knock-on exacerbation and secondary secondary work after drug withdrawal With, patient can be made to produce very big pain, therapeutic process again and again, DeGrain, expense height etc., and tcm clinical practice is to this The therapy of disease, Chinese medicine used refer to out strongly fragrant dispersing stagnated hepatoqi more, or use diet care method, with reference to TCM psychotherapy, Convinced by patient analysis with speech, to release psychological burden, unfold feelings will, harmonizing the functional activities of vital QI.But treat cycle length all be present above, slow curative effect, There is side effect to body, so that cause larger pressure at heart and ailing pressure to patient, to patient and fetus Health all has a significant impact.

The content of the invention

It is an object of the invention to provide a kind of Chinese medicine preparation for being used to treat acute fatty liver of pregnancy, the Chinese medicine preparation pair Have therapeutic effect notable in treatment acute fatty liver of pregnancy, healing time is short, cheap, has no adverse reaction and secondary toxic action The characteristics of.

Inventor is in clinical treatment practice for many years, according to the combination principle of the rule of development of the illness, and Chinese medicine, And by substantial amounts of clinical verification, Exploration and conclusion goes out the new formula of the Chinese medicine preparation for treating acute fatty liver of pregnancy repeatedly. The present invention is notable with therapeutic effect, and healing time is short, cheap, the characteristics of having no adverse reaction with secondary toxic action.

The effect of medicine in the present invention：

Wherein：

Radix glehniae：For the dry of samphire glehnia littoralis Glehnia littoralis Fr. Schmidt ex Miq. Dry.Nature and flavor：Sweet, slight bitter, is slightly cold.Attach to the lung and stomach meridians.Effect：Nourishiing yin to clear away the lung-heat, reinforcing stomach reg fluid.For lung-heat type cough, overstrain cough phlegm Blood, pyreticosis injury thirst.

Oriental wormwood：For feverfew artemisia scoparia Artemisia scoparia Waldst. et Kit. or Artemisia capillaris Artemisia capillaris Thunb. dry aerial parts.Nature and flavor：It is bitter, pungent, it is slightly cold.Returns spleen, stomach, liver, gallbladder channel.Work( Effect：Clearing away damp-heat, removing jaundice subcutaneous ulcer.For jaundice oliguria, wet sore itch；Infectious jaundice type hepatitis.

Fry baiyao：For ranunculaceae plant Chinese herbaceous peony Paeonia lactiflora Pall. dry root processed product.Nature and flavor： Bitter, acid, is slightly cold.Return liver, the spleen channel.Major function：Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, abdomen Bitterly, four limbs contraction pain, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.《Japan hanako materia medica》Described in：Control wind and mend consumptive disease, main woman one Cut disease, and it is antenatal after all diseases, Tong Yueshui, relieving restlessness of bringing down a fever, QI invigorating controls the hot disease of day row, and pest miasma is shied mad, and married woman's blood fortune, and intestines wind are rushed down Blood, hemorrhoid complicated by anal fistula carbuncle on the back, sore scabies, headache, improving eyesight, hot eyes, the triangular mass of mucous membrane growing from the inner corner of the eye.

Desmodium：For Ofthe Primulaceae Lysimachia christinae Lysimachia christinae Hance drying herb.Property Taste：It is sweet, salty, it is slightly cold.Return liver, courage, kidney, bladder warp.Effect：Eliminating dampness and heat, treating stranguria, detumescence.For heat gonorrhea, Sha Lin, puckery work is urinated Bitterly, jaundice, carbuncle swells furunculosis, venomous snake bite；Liver and bile stone, lithangiuria.《Traditional Chinese Medicine in Sichuan will》Described in：Control rheumatism fiber crops Wood, arthralgia and myalgia, jaundice, lung carbuncle.

Rhizoma atractylodis macrocephalae：For the processing of feverfew bighead atractylodes rhizome Atractylodes macrocephala Koidz. dry rhizome Product.Nature and flavor：It is bitter, sweet, temperature.Returns spleen, stomach.Effect：Strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis are antiabortive.For spleen eating less, abdominal distension Diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.Rhizoma Atractylodis Macrocephalae invigorating the spleen, and stomach, it is antiabortive.For spleen eating less, diarrhea loose stool, Fetal irritability.《This warp》Described in：" main wind-cold-dampness arthralgia, dead flesh, convulsion, subcutaneous ulcer, hidroschesis, except heat helps digestion.

Hawthorn：For rosaceous plant large-fruited Chinese hawthorn Crataegus pinnatifida Bge.var.major N.E.Br. or Hawthorn Crataegus pinnatifida Bge. dry mature fruit.Nature and flavor：Sour, sweet, tepor.Returns spleen, stomach, Liver Channel.Work( Effect：Food digesting stomach fortifying, scattered stasis.For meat stagnation, gastral cavilty turgor, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, trusted subordinate's thorn Bitterly, hernia pain；Hyperlipidemia.Charred FRUCTUS CRATAEGI promoting digestion effect enhancing.It is not well for meat stagnation, rush down dysentery.《Book on Chinese herbal medicine is new again》 Described in：Control it is insufficiency of the spleen damp and hot, help digestion mill product, sharp stool and urine.

Buddha's hand：For Rutaceae citrus plant Buddha's hand Citrus medica L. var. sarcodactylis Swingle dry fruit.Nature and flavor：It is pungent, bitter, sour, temperature.Return liver, spleen, lung channel.Effect：Liver-smoothing, qi-regulating, and stomach and alleviating pain.For Stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, deficiency of food vomiting.

Rhizoma atractylodis：For feverfew Atractylis lancea Atractylodes lancea（Thunb.）Or Atractylis chinensis DC. Atractylodes chinensis （DC.）Koidz. dry rhizome.Nature and flavor：It is pungent, bitter, temperature.Returns spleen, stomach, Liver Channel.Work( Effect：It is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.For abdominal fullness and distention, diarrhea, oedema, tinea pedis Wei lame, arthralgia pain due to rheumatism, anemofrigid cold, Yctalopia.《Beautiful Chinese catalpa medicine solution》Described in：Dry native Li Shui, lets out drink dissolving phlegm, the row stasis of blood, opens strongly fragrant, goes leak, to change addiction, and except disease, reason acid regurgitation goes corruption, Mountains and rivers communicable subtropical diseases are warded off, the impotence of time muscles and bones is soft, excessive muddiness of urinating clearly.

Giant knotweed：For polygonaceae plant giant knotweed Polygonum cuspidatum Sieb. et Zucc., dry rhizome and Root.Nature and flavor：Slight bitter, it is slightly cold.Return liver, courage, lung channel.Effect：Expelling wind and removing dampness, scattered stasis pain is relieving cough and reducing sputum.For joint pain, Jaundice with damp-heat pathogen, Amenorrhea, abdominal mass, scald, injury from falling down, carbuncle sore tumefacting virus, coughing with a lot of sputum.《Guizhou prescription collection among the people》Middle note Carry：" astringing to arrest bleeding, hemorrhoid complicated by anal fistula is controlled, curing rheumatism, delivers cold dispelling, scattered blood stasis.

Corydalis tuber：For papaveraceae plant corydalis Corydalis yanhusuo W. T. Wang dry tuber.Property Taste：It is pungent, bitter, temperature.Return liver, the spleen channel.Effect：Promoting blood circulation, sharp gas, analgesic.For chest side of body, epigastric pain, closed dysmenorrhea, the postpartum stasis of blood Resistance, tumbling and swelling.《Japan hanako materia medica》Described in：Except wind, gas is controlled, warms up waist and knee, disease addiction is broken, flutters damage hemostasis, fall tire, and sudden and violent waist Bitterly.

Rhizoma cyperi：For sedge nutgrass flatsedge Cyperus rotundus L. dry rhizome.Nature and flavor：It is pungent, slight bitter, micro- It is sweet, put down.Return liver, spleen, tri-jiao channel.Effect：Promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, chest, the side of body, abdominal distention, digestion It is bad, chest gastral cavity ruffian, cold hernia stomachache, swollen breasts, irregular menstruation, closed dysmenorrhea.《Detailed outline》Described in：The cold epidemic disease of gas, profit when dissipating Three is burnt, Xie Liuyu, and the diet that disappears accumulation, phlegm and retained fluid feeling of fullness, instep swells, abdominal distension, tinea pedis, only trusted subordinate, limbs, head, mesh, tooth, all pains of ear, carbuncle Subcutaneous ulcer sore, spit blood, lower blood, hematuria, under married woman's uterine bleeding band, the moon waits uncomfortable, postpartum all kinds of diseases and ailments before tire.

Citron：For rutaceae citron Citrus medica L. or citrus medic L.（Southwestern citrus medic L.）Citrus wilsonii Tanaka dry mature fruit.Nature and flavor：It is pungent, bitter, sour, temperature.Return liver, spleen, lung channel.Effect：Liver-smoothing, qi-regulating, in wide, resolving sputum.With In stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, epigastric abdominal fullness, vomits gas, many coughs of phlegm.《Book on Chinese herbal medicine is new again》Described in：Soothing the liver Shu Yu, manage lung Gas, stimulate the menstrual flow Li Shui, controls waist tinea pedis.

Fiveleaf akebia fruit：For Ben Tongke plants akebi, threeleaf akebia, Bai Bentong fruit.Nature and flavor：It is sweet, tremble with fear.Effect：Liver of relaxing is managed Gas, promoting blood circulation and stopping pain, relieving restlessness diuresis.Stomachache due to emotional depression and the hyperactive liver-qi attacking the stomach is controlled, stomach energy food is slow-witted, polydipsia, also white dysentery, pain in the back, hypochondriac pain, hernia, cave warp, son Palace drops.《Shaanxi Chinese herbal medicine》Described in：Shugan Yishen, strengthening the spleen and stomach.

Fructus meliae toosendan：For Meliaceae plant melia toosendan Melia toosendan Sieb. et Zucc. dry mature fruit.Property Taste：Hardship, tremble with fear；It is slightly poisonous.Return liver, small intestine, bladder warp.Effect：Easypro liver promoting qi circulation and relieving pain, expelling parasite.For chest side of body, abdominal distention, hernia Bitterly, abdominal pain due to enterositosis.《Medical center bun will》Described in：Purge the sthenic heart-fire, hard kidney water, clearing lung-heat gold, clearing away the liver-fire.Core：Happy hernia, removes obstinate cold syndrome.

The Radix Astragali：For legume astragalus mongolicus Astragalus membranaceus（Fisch.） Bge. var. mongholicus （Bge.）Hsiao or Astragalus membranacus Astragalus membranaceus（Fisch.）Bge. dry Dry.Nature and flavor：It is sweet, temperature.Return lung, the spleen channel.Effect：Invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation.For treatment deficiency of vital energy weak, Anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, the deficiency of blood Impotence is yellow, Heat Diabetes；Chronic rephrilis protinuria, diabetes.

Root tuber of aromatic turmeric：For zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y. H. Chen et C. Ling, turmeric Curcuma longa L., Guangxi zedoary Curcuma kwangsiensis S. G. Lee et C. F. Liang or fluffy cowherbs Art Curcuma phaeocaulis Val. dried root.Nature and flavor：It is pungent, bitter, tremble with fear.Return liver, the heart, lung channel.Effect：Promoting the circulation of qi The stasis of blood, heart fire-clearing upset-relieving, normalizing gallbladder to cure jaundice.Gone mad for closed dysmenorrhea, chest and abdomen swelling and pain, shouting pain, pyreticosis coma, epilepsy, jaundice. 《Essentials of Materia Medica》Described in：Promoting the circulation of qi, Xie Yu；Let out blood, broken stasis of blood.Cool heart heat, dissipates liver depression.

Caulis Perillae：For labiate purple perilla Perilla frutescens（L.）Britt. drying stem.Nature and flavor： It is pungent, temperature.Return lung, the spleen channel.Effect：Regulating the flow of QI to ease the stomach, analgesic are antiabortive.Vexed, the gastral cavity pain for chest diaphragm ruffian, belch vomiting, movement of the foetus is not Peace.《Book on Chinese herbal medicine must be matched somebody with somebody》Described in：It is soothing the liver, sharp lung, qi-regulating, and blood, Xie Yu, analgesic, cough surely, it is antiabortive.

Radix scutellariae：For labiate radix scutellariae Scutellaria baicalensis Georgi dry root.Nature and flavor：Hardship, It is cold.Return lung, courage, spleen, large intestine, small intestinl channel.Effect：Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis are antiabortive.It is uncomfortable in chest for damp-warm syndrome, heat temperature Evil of vomitting, damp and hot feeling of fullness, rush down dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.《This warp》In Record：Main all hot jaundice, intestines Bleach, let out profit, relieve oedema or abdominal distension through diuresis or purgation, and lower blood closes,（Control）Malignant sore, subcutaneous ulcer erosion, fiery ulcer.

Lotus leaf：For nymphaeaceae plant lotus Nelumbo nucifera Gaertn. dried leaf.Nature and flavor：Hardship, put down.Return liver, Spleen, stomach.Effect：Clearing away summerheat, sending up the lucid yang, cooling blood and hemostasis.Told for hot summer weather polydipsia, summer heat damp diarrhea, splenasthenic diarrhea, blood-head Nosebleed, uterine bleeding of having blood in stool.Burnt FOLIUM NELUMBINIS inducing astrigency removing blood stasis and hemostasis.For a variety of haemorrhages and postpartum anemic fainting.《Detailed outline》Described in：Hair tonic member Gas, benefit help taste, and puckery essence is turbid, scattered blood stasis, oedema of confusing, carbuncle swells, send out variola.

Stir-baked RADIX BUPLEURI with vinegar：For umbelliferae bupleurum Bupleurum chinense DC. or radix bupleuri scorzoneraefolii Bupleurum Scorzonerifolium Willd. dry root vinegar product.Nature and flavor：Hardship, it is slightly cold.Return liver, gallbladder channel.Effect：In inducing diaphoresis, dredge Liver, rising Yang.For cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, prolapse of the anus.《Detailed outline》Described in：Control Yang-energy sink, soothing the liver, courage, three burnt, envelope phase fire.

Semen Coicis Semen Coicis：For grass Job's tears Coix lacryma-jobi L. var. ma-yuen（Roman.） Stapf dry mature kernal.Nature and flavor：It is sweet, light, it is cool.Returns spleen, stomach, lung channel.Effect：Invigorating the spleen excreting dampness, remove numbness antidiarrheal, heat-clearing row It is dense.For oedema, tinea pedis, difficult urination, arthritis with fixed pain caused by dampness contraction, splenasthenic diarrhea, lung carbuncle, acute appendicitis；Flat wart.《Detailed outline》Described in：It is strong Spleen benefit stomach, tonifying lung heat-clearing, removes wind prevailing over dampness.Cook a meal food, control cold air；Decoct drink, diuresis heat gonorrhea.

Licorice：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza inflata Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root.Nature and flavor：It is sweet, It is flat.The thoughts of returning home, lung, spleen, stomach.Major function：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.With In weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate medicine poison It is property, strong.《Middle traditional Chinese medicines plant illustrated handbook》Described in：Control peptic ulcer and jaundice.

The present invention square solution be：Oriental wormwood, desmodium, giant knotweed, fiveleaf akebia fruit, radix scutellariae, stir-baked RADIX BUPLEURI with vinegar Return liver, gallbladder channel, have soothing the liver Qi-regulating, hepatic cholagogic effect.Acute fatty liver of pregnancy lesion etiology and pathogenesis is mainly that stagnation of liver qi, catharsis are not normal, so that mechanism of qi Retardance, perverse and unreasonable manner violate stomach, qi disease involving blood, thrombosis and cost disease；It is with the passing of time raw when liver disease affecting spleen, the dysfunction of the spleen in transport, water is wet stops over Phlegm, so that phlegm wet knot, interior strongly fragrant liver and gall and cost disease.Phlegm is turbid to be excluded in time, stop in vivo, the turbid blood stasis of phlegm forms fat Liver.With energy dispersing stagnated hepatoqi, the hepatic cholagogic of adding medicine to, above Six-element medicine is monarch drug in a prescription, and fundamentally dispersing stagnated hepatoqi, liver protection are sharp first Courage, it is that illness obtains basic control.Stir-baked RADIX PAEONIAE ALBA, hawthorn, Buddha's hand, rhizoma atractylodis, corydalis tuber, rhizoma cyperi, citron, Return liver, the spleen channel, the traditional Chinese medical science On say deficiency-weakness of spleen-QI, transporting is unfavorable, essence of water and grain malabsorption, and sanguification source deficiency, or the failure of the spleen to keep the blood flowing within the vessels, is involved excessive blood loss In liver, cause liver-blood deficiency, and then cause hepatopathy.On the one hand above seven flavor medicine aids in monarch drug in a prescription dispersing stagnated hepatoqi, liver protection as ministerial drug Cholagogic；Another aspect expelling wind and removing dampness, soothing liver and strengthening spleen.Radix glehniae, rhizoma atractylodis macrocephalae, Fructus meliae toosendan, the Radix Astragali, root tuber of aromatic turmeric, Caulis Perillae, lotus leaf, life Coix seed, licorice attach to the lung and stomach meridians.Liver governing ascending and dredging, lung governing purification and descending.Liver rises lung drop, and coordination between ascending and descending is smooth to the tune of whole body mechanism of qi, The mediation of qi and blood, important adjustment effect is played, on the one hand auxiliary monarch-minister drug dispersing stagnated hepatoqi, liver protection are sharp as the adjutant in prescription Courage；On the other hand ministerial drug hepatic cholagogic, normalizing gallbladder to cure jaundice are assisted.This side's all medicines share, the monarch and his subjects pull together, and minister assistant shares, and has soothing the liver The effect of qi-regulating, hepatic cholagogic, expelling wind and removing dampness, normalizing gallbladder to cure jaundice, it can effectively treat acute fatty liver of pregnancy.

Medicine material dosage of the present invention is largely groped summary through inventor's progress and drawn, each raw material dosage is following Parts by weight scope all has the effect of preferable：13 ~ 17 parts of radix glehniae, 13 ~ 17 parts of oriental wormwood, 10 ~ 14 parts of stir-baked RADIX PAEONIAE ALBA, desmodium 18 ~ 22 parts, 13 ~ 17 parts of rhizoma atractylodis macrocephalae, 18 ~ 22 parts of hawthorn, 13 ~ 17 parts of Buddha's hand, 10 ~ 14 parts of rhizoma atractylodis, 16 ~ 20 parts of giant knotweed, corydalis tuber 13 ~ 17 parts, 10 ~ 14 parts of rhizoma cyperi, 10 ~ 14 parts of citron, 8 ~ 12 parts of fiveleaf akebia fruit, 10 ~ 14 parts of Fructus meliae toosendan, 28 ~ 32 parts of the Radix Astragali, root tuber of aromatic turmeric 10 ~ 14 Part, 13 ~ 17 parts of Caulis Perillae, 10 ~ 14 parts of radix scutellariae, 10 ~ 14 parts of lotus leaf, 10 ~ 14 parts of stir-baked RADIX BUPLEURI with vinegar, 18 ~ 22 parts of Semen Coicis Semen Coicis, licorice 4 ~ 8 parts.

Wherein it is preferably：15 parts of radix glehniae, 15 parts of oriental wormwood, 12 parts of stir-baked RADIX PAEONIAE ALBA, 20 parts of desmodium, 15 parts of rhizoma atractylodis macrocephalae, hawthorn 20 parts, 15 parts of Buddha's hand, 12 parts of rhizoma atractylodis, 18 parts of giant knotweed, 15 parts of corydalis tuber, 12 parts of rhizoma cyperi, 12 parts of citron, 10 parts of fiveleaf akebia fruit, melia toosendan 12 parts of son, 30 parts of the Radix Astragali, 12 parts of root tuber of aromatic turmeric, 15 parts of Caulis Perillae, 12 parts of radix scutellariae, 12 parts of lotus leaf, 12 parts of stir-baked RADIX BUPLEURI with vinegar, Semen Coicis Semen Coicis 20 Part, 6 parts of licorice.

A kind of preparation method of Chinese medicine preparation for acute fatty liver of pregnancy is as follows：

Step 1：By weight of the present invention, take radix glehniae, oriental wormwood, desmodium, hawthorn, Buddha's hand, rhizoma atractylodis, giant knotweed, prolong Hu Suo, rhizoma cyperi, citron, fiveleaf akebia fruit, Fructus meliae toosendan, the Radix Astragali, root tuber of aromatic turmeric, Caulis Perillae, radix scutellariae, licorice remove impurity, clean, run through, Section, dry, it is standby, hawthorn and Semen Coicis Semen Coicis are wrapped up with lotus leaf, it is standby；

Step 2：By weight proportion of the present invention, by step 1 Chinese medicine radix glehniae, oriental wormwood, stir-baked RADIX PAEONIAE ALBA, rhizoma atractylodis macrocephalae, rhizoma atractylodis, Giant knotweed, corydalis tuber, rhizoma cyperi, the Radix Astragali, root tuber of aromatic turmeric, radix scutellariae, stir-baked RADIX BUPLEURI with vinegar, licorice medicinal material are placed in marmite, add the water of 8 times of volumes, Intense fire infusion 10 ~ 15 minutes, turn slow fire infusion and filter for 20 ~ 30 minutes, add the water of 3 times of volumes, desmodium, Caulis Perillae are thrown Enter in marmite, slow fire infusion obtains filtrate in 10 ~ 15 minutes, finally by hawthorn, Buddha's hand, citron, fiveleaf akebia fruit, Fructus meliae toosendan, lotus leaf, the raw heart of a lotus seed Seed of jog's tears input marmite slow fire infusion 10 ~ 15 minutes, infusion repeatedly merges gained filtrate three times, standby；

Step 3：Filtrate obtained by step 2 is sealed, both traditional Chinese herbal decoction of the present invention.

Application method of the present invention：Decoction of medicinal ingredients is taken to warm, 3 times a day.7 days are a course for the treatment of.

Medicine of the present invention has the function that dispersing stagnated hepatoqi, hepatic cholagogic, expelling wind and removing dampness, normalizing gallbladder to cure jaundice, and effect is good, price It is cheap, have no toxic side effect, easy to use, the Chinese medicine preparation is treated by the way of can reduce wound of the Western medicine to patient body Evil, mitigate the slight illness of patient, according to clinical 100 patient views statistics, use one course for the treatment of total effective rate of medicine of the present invention 88%, two course for the treatment of total effective rates 94%.

Embodiment

Embodiment one：15 parts of radix glehniae, 15 parts of oriental wormwood, 12 parts of stir-baked RADIX PAEONIAE ALBA, 20 parts of desmodium, 15 parts of rhizoma atractylodis macrocephalae, hawthorn 20 Part, 15 parts of Buddha's hand, 12 parts of rhizoma atractylodis, 18 parts of giant knotweed, 15 parts of corydalis tuber, 12 parts of rhizoma cyperi, 12 parts of citron, 10 parts of fiveleaf akebia fruit, Fructus meliae toosendan 12 parts, 30 parts of the Radix Astragali, 12 parts of root tuber of aromatic turmeric, 15 parts of Caulis Perillae, 12 parts of radix scutellariae, 12 parts of lotus leaf, 12 parts of stir-baked RADIX BUPLEURI with vinegar, 20 parts of Semen Coicis Semen Coicis, 6 parts of licorice.

Embodiment two：16 parts of radix glehniae, 16 parts of oriental wormwood, 12 parts of stir-baked RADIX PAEONIAE ALBA, 20 parts of desmodium, 16 parts of rhizoma atractylodis macrocephalae, hawthorn 20 Part, 14 parts of Buddha's hand, 12 parts of rhizoma atractylodis, 18 parts of giant knotweed, 15 parts of corydalis tuber, 12 parts of rhizoma cyperi, 12 parts of citron, 10 parts of fiveleaf akebia fruit, Fructus meliae toosendan 12 parts, 30 parts of the Radix Astragali, 13 parts of root tuber of aromatic turmeric, 16 parts of Caulis Perillae, 11 parts of radix scutellariae, 12 parts of lotus leaf, 11 parts of stir-baked RADIX BUPLEURI with vinegar, 21 parts of Semen Coicis Semen Coicis, 6 parts of licorice.

Embodiment three：15 parts of radix glehniae, 17 parts of oriental wormwood, 12 parts of stir-baked RADIX PAEONIAE ALBA, 20 parts of desmodium, 14 parts of rhizoma atractylodis macrocephalae, hawthorn 21 Part, 16 parts of Buddha's hand, 12 parts of rhizoma atractylodis, 18 parts of giant knotweed, 15 parts of corydalis tuber, 12 parts of rhizoma cyperi, 12 parts of citron, 10 parts of fiveleaf akebia fruit, Fructus meliae toosendan 13 parts, 31 parts of the Radix Astragali, 13 parts of root tuber of aromatic turmeric, 15 parts of Caulis Perillae, 12 parts of radix scutellariae, 12 parts of lotus leaf, 12 parts of stir-baked RADIX BUPLEURI with vinegar, 22 parts of Semen Coicis Semen Coicis, 6 parts of licorice.

Here is the clinical statisticses data that patient uses medicine of the present invention：

First, general information

Accept women gestation patient 100 for medical treatment, patient is randomly divided into observation group and each 50 of control group, wherein max age 38 years old, minimal ages 20 years old, course of disease a few days to a few weeks.Every basic documents such as two groups of patient ages, sex, courses of disease are basic It is identical, no significant difference（P ＞ 0.05）.

2nd, diagnostic criteria

1. laboratory examination

（1）Blood routine examination, leukocyte counts rise are reachable（15.0~30.0）× 109/L, there is poisoning Grain, and see normoblast and basophilic stippling erythrocyte；Platelet count is reduced, the visible loose blood platelet of peripheral blood film.

（2）Serum total bilirubin moderate or severe rise, based on bilirubin direct, are usually no more than 200 μm of ol/L；Blood Transaminase is slight or moderate rise, ALT are no more than 300U/L, there is enzyme-courage segregation phenomenon；Blood alkaline phosphatase is significantly raised；Blood Pure albumen is relatively low, beta Lipoprotein rise.

（3）Blood glucose can be down to l/3~1/2 of normal value, be an AFLP notable feature；Blood ammonia raises, and liver property occurs 10 times of normal value are may be up to during encephalopathic.

（4）Prothrombin time and partial thromboplastin time extend, and fibrinogen reduces.

（5）Blood uric acid, creatinine and urea nitrogen raise.Especially uric acid to increase degree disproportionate with renal function, have When hyperuricemia can there is before AFLP clinical episodes.

（6）Urine protein positive, urine bilirubin are negative.Urine bilirubin feminine gender is one of more important diagnosis, but urine bilirubin The positive can not exclude AFLP.

2. other auxiliary examinations

（1）Imageological examination B ultrasound is shown in the diffusivity high density area of hepatic region, and echo is strong and weak uneven, in flakes, there is typical case Fatty liver waveform.CT and MRI, which is checked, can show fat unnecessary in liver, and liver parenchyma lowers in the density of uniformity.

（2）Pathological examination is the only method for making a definite diagnosis AFLP, can position descending needle biopsy of liver in B ultrasound.1. light microscopic is seen Examine typical case's change into lobuli hepatis structure normal, liver cell diffusivity, droplet steatosis of liver histological, liver cell enlargement, It is common with the liver cell near centrilobular vein；Fat vacuole is dispersed in kytoplasm, karyon is still located at cell center, and structure is not Become；It can be seen that cholestasis, no inflammatory cell infiltration.Under HE dyeing, liver cell becomes in balloon sample, is that the earliest morphology of this disease changes Become, visible eosinophilic body in sinus hepaticus.As liver cell is damaged serious, the then obvious necrosis of appearance and inflammatory reaction.2. Electronic Speculum is examined The visible obvious enlargement of mitochondria under Electronic Speculum is looked into, rupture occurs, loose and ridge reduces, and sees paracrystalline inclusions.Sliding surface and asperities Expanded in endoplasmic reticulum, golgiosome full of lipid.

3rd, treatment method：

1st, observation group weighs bulk drug according to Medications Example one of the present invention（One daily dose）, by invention embodiment party's ruling by law Treat, take decoction of medicinal ingredients to warm, 3 times a day.7 days are a course for the treatment of.

2nd, control group uses adrenocortical hormones in treating method, and the Ureteral Calculus phase is 7 days.

4th, efficacy assessment standard：

1st, cure：Symptom is wholly absent, blood glucose, serum, the equal normal level of blood routine examination.

2nd, take a turn for the better：Symptom not exclusively disappears, and blood glucose is less than normal value, and remaining is returned to normal.

3rd, it is invalid：The change of the inspection results such as blood glucose, serum, blood routine is not very obvious, or even slightly aggravates.

5th, treatment results count：

Control group result counts

Situation is contrasted using the effect of Chinese medicine preparation two courses for the treatment of, two groups of patients

Wherein：Total effective rate=cure rate+improvement rate

Treatment total effective rate by contrasting two groups of patients can be found that observation group apparently higher than control group, thus illustrates, Chinese medicine of the present invention has good clinical effectiveness on acute fatty liver of pregnancy, can effectively improve the cure rate for the treatment of, and effect shows Write, it is cheap, have no adverse reaction and any toxic side effect, there is wide market application foreground.

Model case and curative effect：

Case one, patient Mr. Wang, female, 28 years old, people from Qingdao City, on January 18th, 2013 came here and gone to a doctor.Through examination in hospital, It is diagnosed as acute fatty liver of pregnancy.Hospital is treated using adrenocortical hormones in treating method to patient, and effect is not notable, Carry out here treatment by recommendation.Using made preparation in the embodiment of the present invention one, and selected preparation method, in treatment one After the course for the treatment of, effect is very good, is thoroughly cured after two courses for the treatment of, and clinical symptoms are wholly absent, Effect of follow-up visit by telephone after 2 months, and child is smooth Production.

Case two, patient Lee, female, 29 years old, people from Qingzhou in Shandong province.On May 14th, 2013 comes here and gone to a doctor, after diagnosing symptom It is as follows：Every time after gestation, latter half of gestation miscarriage.Hospital is diagnosed as acute fatty liver of pregnancy on inspection.Swashed using adrenal cortex Extract for treating method is treated 3 years, and symptom is still present, and is got married 5 years and is not educated so far.Later here treatment uses the embodiment of the present invention one In made preparation, and selected preparation method, after a course for the treatment of is treated, effect is very good, thoroughly cures, faces after two courses for the treatment of Bed symptom is wholly absent, and Effect of follow-up visit by telephone has given birth to a youngster after three months, and family life is because the arrival of baby also gets a promotion, mother-in-law Daughter-in-law's relation is further harmonious.

Case three：Song, female, 32 years old, family's Yishui, Shandong, the first visit on the 22nd of September in 2013.Main suit：Get married so far within 2005 Do not educate, each later stage of pregnancy all miscarries, and makes a round of visits ask doctor everywhere, is acute fatty liver of pregnancy by hospital diagnosis.Using adrenal gland Corticosteroid therapy method 4 years, symptom is still present, and does not educate so far.Marital relations once deteriorated.Come me after being introduced to punish Treat, using made preparation in the embodiment of the present invention one, and selected preparation method, after a course for the treatment of is treated, effect is very good, Thoroughly cured after two courses for the treatment of, clinical symptoms are wholly absent, and Effect of follow-up visit by telephone has given birth to a youngster after three months, and one's wedded life obtains Firm, for family life because the arrival of baby also gets a promotion, mother-in-law and daughter-in-law's relation is further harmonious.

Claims (3)

1. a kind of Chinese medicine preparation for acute fatty liver of pregnancy, it is characterised in that the Chinese medicine preparation is by following parts by weight Medicine is made：13 ~ 17 parts of radix glehniae, 13 ~ 17 parts of oriental wormwood, 10 ~ 14 parts of stir-baked RADIX PAEONIAE ALBA, 18 ~ 22 parts of desmodium, rhizoma atractylodis macrocephalae 13 ~ 17 Part, 18 ~ 22 parts of hawthorn, 13 ~ 17 parts of Buddha's hand, 10 ~ 14 parts of rhizoma atractylodis, 16 ~ 20 parts of giant knotweed, 13 ~ 17 parts of corydalis tuber, rhizoma cyperi 10 ~ 14 Part, 10 ~ 14 parts of citron, 8 ~ 12 parts of fiveleaf akebia fruit, 10 ~ 14 parts of Fructus meliae toosendan, 28 ~ 32 parts of the Radix Astragali, 10 ~ 14 parts of root tuber of aromatic turmeric, Caulis Perillae 13 ~ 17 parts, 10 ~ 14 parts of radix scutellariae, 10 ~ 14 parts of lotus leaf, 10 ~ 14 parts of stir-baked RADIX BUPLEURI with vinegar, 18 ~ 22 parts of Semen Coicis Semen Coicis, licorice 4 ~ 8 Part.

2. a kind of Chinese medicine preparation for acute fatty liver of pregnancy according to claim 1, it is characterised in that by following heavy The medicine of amount part is made：15 parts of radix glehniae, 15 parts of oriental wormwood, 12 parts of stir-baked RADIX PAEONIAE ALBA, 20 parts of desmodium, 15 parts of rhizoma atractylodis macrocephalae, 20 parts of hawthorn, 15 parts of Buddha's hand, 12 parts of rhizoma atractylodis, 18 parts of giant knotweed, 15 parts of corydalis tuber, 12 parts of rhizoma cyperi, 12 parts of citron, 10 parts of fiveleaf akebia fruit, Fructus meliae toosendan 12 Part, 30 parts of the Radix Astragali, 12 parts of root tuber of aromatic turmeric, 15 parts of Caulis Perillae, 12 parts of radix scutellariae, 12 parts of lotus leaf, 12 parts of stir-baked RADIX BUPLEURI with vinegar, 20 parts of Semen Coicis Semen Coicis, life 6 parts of radix glycyrrhizae.

A kind of 3. Chinese medicine preparation for acute fatty liver of pregnancy according to claim 1 or 2, it is characterised in that：It is described Chinese medicine preparation is decoction.