CN104587348A - Medicinal composition for bone disease analgesia - Google Patents
Medicinal composition for bone disease analgesia Download PDFInfo
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- CN104587348A CN104587348A CN201510078447.5A CN201510078447A CN104587348A CN 104587348 A CN104587348 A CN 104587348A CN 201510078447 A CN201510078447 A CN 201510078447A CN 104587348 A CN104587348 A CN 104587348A
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Abstract
The invention relates to a medicinal composition for bone disease analgesia. The medicinal composition is prepared from the following raw materials in parts by weight: 70-90 parts of circaea mollis, 70-90 parts of alpinia zerumbet, 70-100 parts of stylophorum lasiocarpum fedde, 50-80 parts of common sage herb, 40-60 parts of bark of quercus mongolica fisch, 30-50 parts of crateva unilocularis, 20-50 parts of peach kernels, 50-80 parts of flatstem rockvine, 40-60 parts of giant knotweed, 30-50 parts of herba epimedii, 40-60 parts of centaury, 30-50 parts of endothelium corneum gigeriae galli, 40-50 parts of gynostemma pentaphylla, 40-50 parts of flower of Japanese glorybower, 30-60 parts of folium nelumbinis, 20-50 parts of ziziphora clinopodioides Lam, 20-50 parts of rhizoma acori talarinowii, 30-50 parts of commelina communis, 40-60 parts of folium ilicis purpurea, 30-50 parts of semen allii tuberose, 20-50 parts of pilea cadierei, 20-60 parts of madder, 40-60 parts of aleuritopteris argentea, 20-50 of parts corydalis adunca maxim, 30-50 parts of a glossy privet fruit, 40-60 parts of parnassia palustris, 30-60 parts of pericarpium citri reticulatae, 20-50 parts of sageretia theezans brongn and 30-50 parts of liquorice. The medicinal composition for bone disease analgesia provided by the invention is reasonable in prescription and has the characteristics of definite treatment effect, high safety and good convenience, no toxic or side effects and low cost.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of for osteopathia analgesic pharmaceutical composition.
Background technology
Osteopathia is substantially modal clinically, and nearly all osteopathia is all with this osteodynia, therefore selects suitable analgesic to be of great significance for treatment osteopathia tool.
Summary of the invention
The object of this invention is to provide a kind of for osteopathia analgesic pharmaceutical composition.
In order to realize object of the present invention, the invention provides a kind of for osteopathia analgesic pharmaceutical composition, it is made up by weight of following bulk drugs: Herba Circaeae mollis 70-90 part, shellflower 70-90 part, Herba Stylophori Lasiocapi 70-100 part, Herba Salviae Plebeiae 50-80 part, Cortex Querci Mongolicae 40-60 part, tree head dish 30-50 part, Semen Persicae 20-50 part, Caulis et Radix Tetrastigmatis Planicaulis 50-80 part, Rhizoma Polygoni Cuspidati 40-60 part, Herba Epimedii 30-50 part, Herba centaurll altaici 40-60 part, Endothelium Corneum Gigeriae Galli 30-50 part, Herb Gynostemmae Pentaphylli 40-50 part, Flos clerodendri japonici 40-50 part, Folium Nelumbinis 30-60 part, lip Rhizoma et radix valerianae 20-50 part, Rhizoma Acori Graminei 20-50 part, Herba Commelinae 30-50 part, Ilex purpurea Hassk.[I.chinensis Sims 40-60 part, Semen Allii Tuberosi 30-50 part, Rhizoma Belamcandae 20-50 part, Radix Rubiae 20-60 part, Aleuritopteris argentea (Gmel.) Fee 40-60 part, Dendrobium denneanum Kerr. flower 20-50 part, Fructus Ligustri Lucidi 30-50 part, Herba parnassiae 40-60 part, Pericarpium Citri Reticulatae 30-60 part, Cacumen et folium sageretiae 20-50 part and Radix Glycyrrhizae 30-50 part.
Preferably, described is be made up by weight of following bulk drugs for osteopathia analgesic pharmaceutical composition: Herba Circaeae mollis 85 parts, shellflower 80 parts, Herba Stylophori Lasiocapi 85 parts, Herba Salviae Plebeiae 70 parts, Cortex Querci Mongolicae 50 parts, tree head dish 45 parts, 35 parts, Semen Persicae, Caulis et Radix Tetrastigmatis Planicaulis 60 parts, Rhizoma Polygoni Cuspidati 50 parts, Herba Epimedii 40 parts, Herba centaurll altaici 50 parts, Endothelium Corneum Gigeriae Galli 45 parts, Herb Gynostemmae Pentaphylli 45 parts, Flos clerodendri japonici 45 parts, 45 parts, Folium Nelumbinis, lip Rhizoma et radix valerianae 35 parts, Rhizoma Acori Graminei 30 parts, Herba Commelinae 40 parts, Ilex purpurea Hassk.[I.chinensis Sims 50 parts, Semen Allii Tuberosi 45 parts, Rhizoma Belamcandae 30 parts, 30 parts, Radix Rubiae, Aleuritopteris argentea (Gmel.) Fee 45 parts, Dendrobium denneanum Kerr. spends 30 parts, Fructus Ligustri Lucidi 35 parts, Herba parnassiae 50 parts, Pericarpium Citri Reticulatae 50 parts, Cacumen et folium sageretiae 30 parts and 35 parts, Radix Glycyrrhizae.
More preferably, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
The present invention also provides compositions for the preparation of the purposes in the medicine of osteopathia analgesic, described compositions is made up by weight of following bulk drugs: Herba Circaeae mollis 70-90 part, shellflower 70-90 part, Herba Stylophori Lasiocapi 70-100 part, Herba Salviae Plebeiae 50-80 part, Cortex Querci Mongolicae 40-60 part, tree head dish 30-50 part, Semen Persicae 20-50 part, Caulis et Radix Tetrastigmatis Planicaulis 50-80 part, Rhizoma Polygoni Cuspidati 40-60 part, Herba Epimedii 30-50 part, Herba centaurll altaici 40-60 part, Endothelium Corneum Gigeriae Galli 30-50 part, Herb Gynostemmae Pentaphylli 40-50 part, Flos clerodendri japonici 40-50 part, Folium Nelumbinis 30-60 part, lip Rhizoma et radix valerianae 20-50 part, Rhizoma Acori Graminei 20-50 part, Herba Commelinae 30-50 part, Ilex purpurea Hassk.[I.chinensis Sims 40-60 part, Semen Allii Tuberosi 30-50 part, Rhizoma Belamcandae 20-50 part, Radix Rubiae 20-60 part, Aleuritopteris argentea (Gmel.) Fee 40-60 part, Dendrobium denneanum Kerr. flower 20-50 part, Fructus Ligustri Lucidi 30-50 part, Herba parnassiae 40-60 part, Pericarpium Citri Reticulatae 30-60 part, Cacumen et folium sageretiae 20-50 part and Radix Glycyrrhizae 30-50 part.
Preferably, described compositions is made up by weight of following bulk drugs: Herba Circaeae mollis 85 parts, shellflower 80 parts, Herba Stylophori Lasiocapi 85 parts, Herba Salviae Plebeiae 70 parts, Cortex Querci Mongolicae 50 parts, tree head dish 45 parts, 35 parts, Semen Persicae, Caulis et Radix Tetrastigmatis Planicaulis 60 parts, Rhizoma Polygoni Cuspidati 50 parts, Herba Epimedii 40 parts, Herba centaurll altaici 50 parts, Endothelium Corneum Gigeriae Galli 45 parts, Herb Gynostemmae Pentaphylli 45 parts, Flos clerodendri japonici 45 parts, 45 parts, Folium Nelumbinis, lip Rhizoma et radix valerianae 35 parts, Rhizoma Acori Graminei 30 parts, Herba Commelinae 40 parts, Ilex purpurea Hassk.[I.chinensis Sims 50 parts, Semen Allii Tuberosi 45 parts, Rhizoma Belamcandae 30 parts, 30 parts, Radix Rubiae, Aleuritopteris argentea (Gmel.) Fee 45 parts, Dendrobium denneanum Kerr. spends 30 parts, Fructus Ligustri Lucidi 35 parts, Herba parnassiae 50 parts, Pericarpium Citri Reticulatae 50 parts, Cacumen et folium sageretiae 30 parts and 35 parts, Radix Glycyrrhizae.
More preferably, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
In the present invention, Herba Circaeae mollis, shellflower are monarch drug; Herba Stylophori Lasiocapi, Herba Salviae Plebeiae, Cortex Querci Mongolicae, tree head dish, Semen Persicae, Caulis et Radix Tetrastigmatis Planicaulis are ministerial drug; Rhizoma Polygoni Cuspidati, Herba Epimedii, Herba centaurll altaici, Endothelium Corneum Gigeriae Galli, Herb Gynostemmae Pentaphylli, Flos clerodendri japonici, Folium Nelumbinis, lip Rhizoma et radix valerianae, Rhizoma Acori Graminei, Herba Commelinae, Ilex purpurea Hassk.[I.chinensis Sims, Semen Allii Tuberosi, Rhizoma Belamcandae, Radix Rubiae, Aleuritopteris argentea (Gmel.) Fee, Dendrobium denneanum Kerr. flower, Fructus Ligustri Lucidi, Herba parnassiae, Pericarpium Citri Reticulatae, Cacumen et folium sageretiae are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, plays the effect making medicine in the compositions of the present invention.All medicines are harmonious in the present invention, reasonable recipe, have determined curative effect, safe ready, have no side effect, cheap feature.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment lotion of the present invention
Take Herba Circaeae mollis 85 grams, shellflower 80 grams, Herba Stylophori Lasiocapi 85 grams, Herba Salviae Plebeiae 70 grams, Cortex Querci Mongolicae 50 grams, tree head dish 45 grams, 35 grams, Semen Persicae, Caulis et Radix Tetrastigmatis Planicaulis 60 grams, Rhizoma Polygoni Cuspidati 50 grams, Herba Epimedii 40 grams, Herba centaurll altaici 50 grams, Endothelium Corneum Gigeriae Galli 45 grams, Herb Gynostemmae Pentaphylli 45 grams, Flos clerodendri japonici 45 grams, 45 grams, Folium Nelumbinis, lip Rhizoma et radix valerianae 35 grams, Rhizoma Acori Graminei 30 grams, Herba Commelinae 40 grams, Ilex purpurea Hassk.[I.chinensis Sims 50 grams, Semen Allii Tuberosi 45 grams, Rhizoma Belamcandae 30 grams, 30 grams, Radix Rubiae, Aleuritopteris argentea (Gmel.) Fee 45 grams, Dendrobium denneanum Kerr. spends 30 grams, Fructus Ligustri Lucidi 35 grams, Herba parnassiae 50 grams, Pericarpium Citri Reticulatae 50 grams, Cacumen et folium sageretiae 30 grams and 35 grams, Radix Glycyrrhizae, add 10 liters, water, heating 6 hours under the condition of backflow, filter, filtrate is made to be cooled to room temperature and to get final product.
Experimental example
Choose sciatica patient totally 80 examples, wherein man 40 example, female 40 example, the age be 29-53 year, diagnostic criteria is with reference to " clinical disease diagnosis according to and cure improvement standard " (Sun Chuanxing, People's Medical Officer Press, in June, 1998, the 2nd edition) formulate, specific as follows: (1) is along the radiated pain of sciatic nerve areal area, during radiculopathy, the actions such as cough, sneeze often make pain increase the weight of.For palliating a disease, spinal column often has lateral bending, and during bed, knee often has micro-song.(2) pressure pain point is had along sciatic nerve areal area, as waist (side) point, ilium point, buttocks point, rouge point, diseased point, ankle point etc.(3) sciatic nerve involves and levies the normal positive.(4) motion in various degree, sensation, reflection and autonomic nerve obstacle is had within the scope of sciatic nerve domination.(5) X takes the photograph sheet or CT or MRI and checks and do not find lumbar vertebra, bones of the body bone, bones of the body arthropathy.
The lotion prepared in embodiment is used to treat, every day three times, each use 500 milliliters of washing liquids, insulation is at 50 DEG C, use sterile gauze flood, then by sterile gauze soak at sore place, after gauze temperature is reduced to body temperature, again sterile gauze is immersed in washing liquid, then continues soak.Each soak so repeatedly 30 minutes.Continuous treatment 7 days.
Observation index
Behavior pain determining (BRS-6, behavioral rating scale)
BRS-6 standards of grading are as follows:
Without pain 0 point
There is pain, but easily 1 point out in the cold
There is pain, cannot ignore, but do not affect daily life 2 points
There is pain, cannot ignore, disturbance of concentration 3 points
There is pain, cannot ignore, all daily life all effecteds, but basic physiological demand can be completed as feed etc. 4 points
Existence has an intense pain, and cannot ignore, and needs have a rest or lie up 5 points
Criterion of therapeutical effect
Curative effect determinate standard is formulated as follows with reference to State Administration of Traditional Chinese Medicine's " disease of tcm diagnosis and criterion of therapeutical effect ":
Cure: lumbago and skelalgia disappears, leg raising straight more than 70 °, the extensive recovery operation of energy;
Effective: lumbago and skelalgia alleviates, waist movable function improves;
Invalid: symptom, sign are without improvement.
Effective percentage=(cure+effective) number of cases/total number of cases × 100%
Therapeutic outcome
BRS-6 scoring is 5.32+1.36 before the treatment, and BRS-6 scoring is 2.26+1.08 after the treatment.BRS-6 diversity of values before and after treatment has statistical significance (p < 0.05).Find in 80 routine patients, cure 58 examples, effective is 22 examples, and total effective rate is 100%.
Untoward reaction and toxic and side effects supervision
By detect patient blood pressure, pulse, whether there is Nausea and vomiting, dizzy clinical symptoms judges untoward reaction.Find that the systolic pressure of all patients is between 90-140mmHg, diastolic pressure is between 60-90mmHg, and pulse is 60-100 beat/min, and blood pressure and pulse all within normal range, and does not occur Nausea and vomiting, dizzy clinical symptoms.This illustrates that pharmaceutical composition of the present invention does not have obvious untoward reaction, and then proves that medicine does not have obvious toxic and side effects for human body.
Claims (6)
1. one kind for osteopathia analgesic pharmaceutical composition, it is characterized in that, it is made up by weight of following bulk drugs: Herba Circaeae mollis 70-90 part, shellflower 70-90 part, Herba Stylophori Lasiocapi 70-100 part, Herba Salviae Plebeiae 50-80 part, Cortex Querci Mongolicae 40-60 part, tree head dish 30-50 part, Semen Persicae 20-50 part, Caulis et Radix Tetrastigmatis Planicaulis 50-80 part, Rhizoma Polygoni Cuspidati 40-60 part, Herba Epimedii 30-50 part, Herba centaurll altaici 40-60 part, Endothelium Corneum Gigeriae Galli 30-50 part, Herb Gynostemmae Pentaphylli 40-50 part, Flos clerodendri japonici 40-50 part, Folium Nelumbinis 30-60 part, lip Rhizoma et radix valerianae 20-50 part, Rhizoma Acori Graminei 20-50 part, Herba Commelinae 30-50 part, Ilex purpurea Hassk.[I.chinensis Sims 40-60 part, Semen Allii Tuberosi 30-50 part, Rhizoma Belamcandae 20-50 part, Radix Rubiae 20-60 part, Aleuritopteris argentea (Gmel.) Fee 40-60 part, Dendrobium denneanum Kerr. flower 20-50 part, Fructus Ligustri Lucidi 30-50 part, Herba parnassiae 40-60 part, Pericarpium Citri Reticulatae 30-60 part, Cacumen et folium sageretiae 20-50 part and Radix Glycyrrhizae 30-50 part.
2. according to claim 1 for osteopathia analgesic pharmaceutical composition, it is characterized in that, it is made up by weight of following bulk drugs: Herba Circaeae mollis 85 parts, shellflower 80 parts, Herba Stylophori Lasiocapi 85 parts, Herba Salviae Plebeiae 70 parts, Cortex Querci Mongolicae 50 parts, tree head dish 45 parts, 35 parts, Semen Persicae, Caulis et Radix Tetrastigmatis Planicaulis 60 parts, Rhizoma Polygoni Cuspidati 50 parts, Herba Epimedii 40 parts, Herba centaurll altaici 50 parts, Endothelium Corneum Gigeriae Galli 45 parts, Herb Gynostemmae Pentaphylli 45 parts, Flos clerodendri japonici 45 parts, 45 parts, Folium Nelumbinis, lip Rhizoma et radix valerianae 35 parts, Rhizoma Acori Graminei 30 parts, Herba Commelinae 40 parts, Ilex purpurea Hassk.[I.chinensis Sims 50 parts, Semen Allii Tuberosi 45 parts, Rhizoma Belamcandae 30 parts, 30 parts, Radix Rubiae, Aleuritopteris argentea (Gmel.) Fee 45 parts, Dendrobium denneanum Kerr. spends 30 parts, Fructus Ligustri Lucidi 35 parts, Herba parnassiae 50 parts, Pericarpium Citri Reticulatae 50 parts, Cacumen et folium sageretiae 30 parts and 35 parts, Radix Glycyrrhizae.
3. according to claim 1ly it is characterized in that for osteopathia analgesic pharmaceutical composition, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
4. compositions is for the preparation of the purposes in the medicine of osteopathia analgesic, it is characterized in that, described compositions is made up by weight of following bulk drugs: Herba Circaeae mollis 70-90 part, shellflower 70-90 part, Herba Stylophori Lasiocapi 70-100 part, Herba Salviae Plebeiae 50-80 part, Cortex Querci Mongolicae 40-60 part, tree head dish 30-50 part, Semen Persicae 20-50 part, Caulis et Radix Tetrastigmatis Planicaulis 50-80 part, Rhizoma Polygoni Cuspidati 40-60 part, Herba Epimedii 30-50 part, Herba centaurll altaici 40-60 part, Endothelium Corneum Gigeriae Galli 30-50 part, Herb Gynostemmae Pentaphylli 40-50 part, Flos clerodendri japonici 40-50 part, Folium Nelumbinis 30-60 part, lip Rhizoma et radix valerianae 20-50 part, Rhizoma Acori Graminei 20-50 part, Herba Commelinae 30-50 part, Ilex purpurea Hassk.[I.chinensis Sims 40-60 part, Semen Allii Tuberosi 30-50 part, Rhizoma Belamcandae 20-50 part, Radix Rubiae 20-60 part, Aleuritopteris argentea (Gmel.) Fee 40-60 part, Dendrobium denneanum Kerr. flower 20-50 part, Fructus Ligustri Lucidi 30-50 part, Herba parnassiae 40-60 part, Pericarpium Citri Reticulatae 30-60 part, Cacumen et folium sageretiae 20-50 part and Radix Glycyrrhizae 30-50 part.
5. purposes according to claim 4, it is characterized in that, described compositions is made up by weight of following bulk drugs: Herba Circaeae mollis 85 parts, shellflower 80 parts, Herba Stylophori Lasiocapi 85 parts, Herba Salviae Plebeiae 70 parts, Cortex Querci Mongolicae 50 parts, tree head dish 45 parts, 35 parts, Semen Persicae, Caulis et Radix Tetrastigmatis Planicaulis 60 parts, Rhizoma Polygoni Cuspidati 50 parts, Herba Epimedii 40 parts, Herba centaurll altaici 50 parts, Endothelium Corneum Gigeriae Galli 45 parts, Herb Gynostemmae Pentaphylli 45 parts, Flos clerodendri japonici 45 parts, 45 parts, Folium Nelumbinis, lip Rhizoma et radix valerianae 35 parts, Rhizoma Acori Graminei 30 parts, Herba Commelinae 40 parts, Ilex purpurea Hassk.[I.chinensis Sims 50 parts, Semen Allii Tuberosi 45 parts, Rhizoma Belamcandae 30 parts, 30 parts, Radix Rubiae, Aleuritopteris argentea (Gmel.) Fee 45 parts, Dendrobium denneanum Kerr. spends 30 parts, Fructus Ligustri Lucidi 35 parts, Herba parnassiae 50 parts, Pericarpium Citri Reticulatae 50 parts, Cacumen et folium sageretiae 30 parts and 35 parts, Radix Glycyrrhizae.
6. purposes according to claim 4, is characterized in that, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or lotion.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510078447.5A CN104587348A (en) | 2015-02-13 | 2015-02-13 | Medicinal composition for bone disease analgesia |
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| CN201510078447.5A CN104587348A (en) | 2015-02-13 | 2015-02-13 | Medicinal composition for bone disease analgesia |
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| CN201510078447.5A Pending CN104587348A (en) | 2015-02-13 | 2015-02-13 | Medicinal composition for bone disease analgesia |
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| CN1593576A (en) * | 2004-07-13 | 2005-03-16 | 蒋明 | Medicinal wine for expelling wind, eliminating dampness, relaxing tendon and stopping pain |
| CN1606997A (en) * | 2003-10-14 | 2005-04-20 | 唐莹 | Plaster for bone disease |
| CN1739619A (en) * | 2005-09-12 | 2006-03-01 | 董伟胜 | Medicine for treating backbone disease |
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2015
- 2015-02-13 CN CN201510078447.5A patent/CN104587348A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1606997A (en) * | 2003-10-14 | 2005-04-20 | 唐莹 | Plaster for bone disease |
| CN1593576A (en) * | 2004-07-13 | 2005-03-16 | 蒋明 | Medicinal wine for expelling wind, eliminating dampness, relaxing tendon and stopping pain |
| CN1739619A (en) * | 2005-09-12 | 2006-03-01 | 董伟胜 | Medicine for treating backbone disease |
Non-Patent Citations (2)
| Title |
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| 徐友霞 等: "中医药治疗类风湿关节炎的临床研究进展", 《世界中西医结合杂志》 * |
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