CN104587343A - Traditional Chinese medicine for replenishing qi and nourishing yin of hyperthyroidism patients and preparation method - Google Patents
Traditional Chinese medicine for replenishing qi and nourishing yin of hyperthyroidism patients and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for replenishing qi and nourishing yin of hyperthyroidism patients. The traditional Chinese medicine is prepared from the following active pharmaceutical ingredients in parts by weight: 15-20 parts of angelica sinensis, 9-16 parts of concha haliotidis, 10-20 parts of eucommia ulmoides, 10-14 parts of fructus corni, 10-20 parts of radix trichosanthis, 9-18 parts of semen platycladi, 8-16 parts of rhizoma galangae, 6-9 parts of radix ranunculi ternati, 7-14 parts of winged laggera herb, 15-30 parts of rhizoma dioscoreae, 15-30 parts of tangerine peel, 6-12 parts of flos carthami, 6-12 parts of codonopsis pilosula, 3-6 parts of airpotato yam rhizome, 8-12 parts of radix scrophulariae, 6-9 parts of spica prunellae, 15-20 parts of radix aucklandiae, 15-20 parts of raw rhizoma atractylodis macrocephalae, 8-12 parts of rhizoma sparganii and 15-20 parts of fructus psoraleae. The traditional Chinese medicine disclosed by the invention has the following good effects: the medicine has the functions of nourishing yin and replenishing qi, removing goiter and stasis, nourishing heart and tranquilizing mind and clearing heat and removing toxicity and has a remarkable curative effect on hyperthyroidism symptoms; moreover, the medicine is developed based on the syndrome differentiation and treatment of traditional Chinese medicine and in combination with modern latest scientific achievements; and by combining the medicinal materials, the medicine has the characteristics of remarkable curative effect, safety and convenience and low price.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine and preparation method.
Background technology
Hyperthyroidism is hyperthyroid abbreviation, is the common endocrinopathy of the thyroid hormone secretion caused by many reasons one group of too much causing.Main clinic symptoms is polyphagia, becomes thin, fears heat, hyperhidrosis, cardiopalmus, exciting contour metabolic syndrome, neural and blood vessel excitement strengthens, and thyromegaly in various degree and eye is prominent, hand tremor, Cervical Vessels noise etc. be feature, serious occurred hyperthyroidism is endangered phase, even threat to life of going into a coma.
Hyperthyroidism is various, and motherland's medical science is returned in the category of the disease such as " goiter ", " in disappear ", " cardiopalmus ", " diarrhoea ", " stagnation of liver-QI " according to its Symptoms.Professor Li Tianming thinks that how real the primary disease initial stage is, based on YANG MING heat syndrome.The hyperthyroidism initial stage, stagnated QI transforming into fire, Yang Reneisheng, vehement in gallbladder fire, impairment of body fluid consumption gas, sick at internal organs, such as gallbladder fire, fear heat.Mid-term deficiency and excess seeing, based on the expectorant blood coagulation stasis of blood.Hyperthyroidism mid-term, or because of pathogenic fire refining liquid be expectorant; Or because of depression and stagnation of QI, Tianjin is rather expectorant, and stasis is the stasis of blood; Pathogenic fire is burnt cloudy blood, hyperactivity of YANG due to deficiency of YIN, liver-wind stirring up internally.In the hyperthyroidism later stage, the course of disease is delayed, and consumption impairment of QI is cloudy, and the five internal organs are got involved, edema with the liver involved perverse and unreasonable manner, and spleen soil is injured, causes stagnation of liver-QI with deficiency of the spleen, disease damage and kidney, and stagnation of QI expectorant coagulates.
Application publication number CN 102441110 A(application number 201110392147.6) Chinese invention patent document discloses a kind of Chinese medicine composition of adjuvant treatment of hyperthyroidism, the component by following parts by weight: Fructus Schisandrae Chinensis 3-5 part, Rhizoma Polygonati 2-4 part, Radix Astragali 3-4 part, Radix Bupleuri 10-13 part, Radix Pulsatillae 3-6 part, Rhizoma Alismatis 2-5 part, Concha Ostreae 6-8 part, Spica Prunellae 1-2 part, Radix Asparagi 2-6 part, Bulbus Fritillariae Thunbergii 2-4 part, Fructus Mume 4-7 part, Herba Violae 4-6 part, Radix Polygoni Multiflori 1-2 part, Calyx Kaki 4-6 part, Rhizoma Anemarrhenae 1-2 part.Application publication number CN 103446392 A(application number 201210171225.4) Chinese invention patent document discloses a kind of Chinese medicine for the treatment of hyperthyroidism, is made up of the medical material of following weight portion: Aloe 8 parts, Herba Menthae 8 parts, Radix Et Rhizoma Rhei 8 parts, Fructus Momordicae 15 parts, Flos Rosae Rugosae 15 parts, the Radix Angelicae Dahuricae 8 parts, Radix Angelicae Sinensis 8 parts, Lignum Aquilariae Resinatum 15 parts, 5 parts, Poria.Application publication number CN 103566027 A(application number 201210262111.0) Chinese invention patent document discloses a kind of medicine for the treatment of hyperthyroidism, the ratio of weight and number of each crude drug is: Thallus Laminariae (Thallus Eckloniae) 15-25 part, Spica Prunellae 12-25 part, Sargassum 15-20 part, Semen Cassiae 8-15 part, Radix Morindae Officinalis 10-18 part, Cortex Eucommiae 8-12 part, Fructus Chaenomelis 6-15 part, Radix Glycyrrhizae 9-12 part, Poria 8-15 part, Radix Scrophulariae 12-16 part.
The Therapeutic Method of hyperthyroidism mainly contains: operative treatment, " THS " treatment and triple therapy etc., and operative treatment proves effective rapidly, but excises very few, easily recurs; Excision too much, can cause the complication such as first is low again.In recent years, the sickness rate of hyperthyroidism raises year by year, the Therapeutic Method such as doctor trained in Western medicine operation bring considerable distress to patient, the advantage of Chinese medicine in Treatment of Hyperthyroidism manifests gradually, Chinese medicine has played great function improving on symptom and objective experimental index, embody disease of tcm opinion to control, the feature for the treatment of must aim at the pathogenesis of disease.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that one is prepared simply, taking convenience, safely and effectively a kind of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine and method for making.Chinese medicine determined curative effect of the present invention is convenient to Clinical practice.
Technical scheme of the present invention is:
Hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Angelicae Sinensis 15-20; Concha Haliotidis 9-16; Cortex Eucommiae 10-20; Fructus Corni 10-14; Radix Trichosanthis 10-20; Semen Platycladi 9-18; Rhizoma Alpiniae Officinarum 8-16; Radix Ranunculi Ternati 6-9; Herba Laggerae Alatae 7-14; Rhizoma Dioscoreae 15-30; Pericarpium Citri Reticulatae 15-30; Flos Carthami 6-12; Radix Codonopsis 6-12; Rhizoma Dioscoreae Bulbiferae 3-6; Radix Scrophulariae 8-12; Spica Prunellae 6-9; Radix Aucklandiae 15-20; Rhizoma Atractylodis Macrocephalae 15-20; Rhizoma Sparganii 8-12; Fructus Psoraleae 15-20.
In preferred scheme, Radix Angelicae Sinensis 17-18; Concha Haliotidis 12-13; Cortex Eucommiae 13-17; Fructus Corni 11-13; Radix Trichosanthis 13-17; Semen Platycladi 12-15; Rhizoma Alpiniae Officinarum 11-13; Radix Ranunculi Ternati 7-8; Herba Laggerae Alatae 9-12; Rhizoma Dioscoreae 20-25; Pericarpium Citri Reticulatae 20-25; Flos Carthami 8-10; Radix Codonopsis 8-10; Rhizoma Dioscoreae Bulbiferae 4-5; Radix Scrophulariae 9-11; Spica Prunellae 7-8; Radix Aucklandiae 17-18; Rhizoma Atractylodis Macrocephalae 17-18; Rhizoma Sparganii 9-11; Fructus Psoraleae 17-18.
Be more preferably, Radix Angelicae Sinensis 17.5; Concha Haliotidis 12.5; The Cortex Eucommiae 15; Fructus Corni 12; Radix Trichosanthis 15; Semen Platycladi 13.5; Rhizoma Alpiniae Officinarum 12; Radix Ranunculi Ternati 7.5; Herba Laggerae Alatae 10.5; Rhizoma Dioscoreae 22.5; Pericarpium Citri Reticulatae 22.5; Flos Carthami 9; Radix Codonopsis 9; Rhizoma Dioscoreae Bulbiferae 4.5; Radix Scrophulariae 10; Spica Prunellae 7.5; The Radix Aucklandiae 17.5; Rhizoma Atractylodis Macrocephalae 17.5; Rhizoma Sparganii 10; Fructus Psoraleae 17.5。
Hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction, preparation method is as follows:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, and be then placed in rice vinegar and quench 4-8 processed minute (be preferably placed in rice vinegar quench system 6 minutes), take out, drying, pulverizes for subsequent use; Fructus Psoraleae is cleaned, and soaks (preferably soak 1 with saline solution in 1-2 hour with saline solution.5 hours), take out, dry, be placed in frying pan, add Oleum Helianthi, slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use; By Concha Haliotidis powder and the mixing of Psoralen cosmetics, sieve for subsequent use;
(2) be placed in medicine pot by clean respectively to Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae, add Zhenjiang rice vinegar and do not have powder, moderate heat heats, and decocts 5-10 minute (preferably decocting 8 minutes), takes out, drying for standby;
(3) crude drug except Concha Haliotidis, Fructus Psoraleae, Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae is poured in medicinal cupping, add the distilled water immersion (preferably adding the distilled water immersion of 9 times of material quantities) of 8-10 times of material quantity, add the crude drug that step (1) and step (2) processed, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 40-60 minute (preferably first time decocts 50 minutes), second time decocts 25-35 minute (preferably second time decocts 30 minutes), filter, collecting decoction;
(4) above-mentioned decocting liquid is evaporated to 2/3 of original liquid volume, dry heat sterilization 15-25 minute (preferred dry heat sterilization 20 minutes), cooling, encapsulation, to obtain final product.
The preparation method of above-mentioned hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction, preferred scheme is, the middle 70-130 mesh sieve excessively of step (1) (preferred 90-110 mesh sieve excessively, mistake 100 mesh sieve be more preferably).
The preparation method of above-mentioned hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction, preferred scheme is, in step (3), the time of distilled water immersion is 1-1.Within 6 hours, (time of preferred distilled water immersion is 1.2-1。4 hours, the time of the distilled water immersion be more preferably was 1.3 hours).
The preparation method of above-mentioned hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction, preferred scheme is, in step (4), the temperature of dry heat sterilization is 97-105 DEG C (temperature of preferred dry heat sterilization is 100-102 DEG C, and the temperature of the dry heat sterilization be more preferably is 101 DEG C).
The preparation method of described granule is:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, and be then placed in rice vinegar and quench 4-8 processed minute (be preferably placed in rice vinegar quench system 6 minutes), take out, drying, pulverizes for subsequent use; Rhizoma Sparganii sheet is placed in medicine pot, intense fire heat, fry to surface blackening, crisp for degree, take out, cool, pulverization is for subsequent use;
(2) Semen Platycladi is cleaned, and dries, and crushes, and with toilet paper parcel, put in frying pan, slow fire heats, and roasting is deoiled, fine ground for subsequent use; Fructus Psoraleae is cleaned, and soaks (preferably soak 1 with saline solution in 1-2 hour with saline solution.5 hours), take out, dry, be placed in frying pan, add Oleum Helianthi, slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use;
(3) by step (1)-step (2) gained fine medicinal material powder, stir, cross 50-90 mesh sieve (preferred mistake 70 mesh sieve), obtain mixing fine powders;
(4) medical material except Concha Haliotidis, Rhizoma Sparganii, Semen Platycladi and Fructus Psoraleae is cleaned respectively, dry, put into medicinal cupping, the mass fraction adding 10 times of material quantities is the ethanol of 70%-90% (mass fraction preferably adding 10 times of material quantities is the ethanol of 80%), airtight dipping 1-1.4 hours (preferred airtight dippings 1.2 hours), heating and refluxing extraction twice, first time extracts 55-65 minute (preferably first time extracts 60 minutes), and second time is extracted 30-50 minute (preferably second time is extracted 40 minutes), filters, merge extractive liquid, reclaims ethanol;
(5) above-mentioned gained extracting solution being evaporated to 85 DEG C of relative densities is 1.30-1。The thick paste of 33; In thick paste, add step (3) gained fine powder, add sucrose, amylum pregelatinisatum and sodium cellulosate (thick paste powder: sucrose: amylum pregelatinisatum: sodium cellulosate=5:0.9:0.7:0.7), granulate, cross No. six sieves, be processed into granule, obtain final product.
The preparation method of described tablet is:
(1) Rhizoma Sparganii sheet is cleaned, and adding soaking in Chinese liquor 2-4 hour (preferably adding soaking in Chinese liquor 3 hours), frying Testa Tritici to smoldering simultaneously in frying pan, add the Rhizoma Sparganii sheet steeped, and moderate heat heats, and fry to yellow, sieve removes Testa Tritici, lets cool, is ground into fine powder for subsequent use; By rice in medicine pot, when moderate heat is heated to meter smoke, pour Radix Codonopsis sheet into, frying to rice is strong yellow, takes out, and sieve removes rice, cools, smashs to pieces for subsequent use;
(2) Radix Angelicae Sinensis Tabellae is placed in medicine pot, and add Shanxi mature vinegar and do not have powder 2-4cm, intense fire is heated to boil, and turns slow fire boiling 6-10 minute (preferably turning slow fire boiling 8 minutes), takes out, dry, smashs to pieces for subsequent use; Concha Haliotidis smashs into end to pieces, for subsequent use;
(3) crude drug except Rhizoma Sparganii, Radix Codonopsis, Radix Angelicae Sinensis and Concha Haliotidis is cleaned respectively, in 120 DEG C of hot air drying 35-55 minutes (being preferable over 120 DEG C of hot air dryings 45 minutes), being then placed in Chinese medicine grinder and being ground into fine powder;
(4) by step (1)-(3) gained fine powder mixing, cross 110-150 mesh sieve (preferred mistake 130 mesh sieve), add magnesium stearate and dextrin (medicated powder: magnesium stearate: dextrin=5:1.1:0.9), be placed in tablet machine and be pressed into tablet, to obtain final product.
The preparation method of described pill is:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, is placed in yellow wine and floods 1-3 minute (being preferably placed in yellow wine dipping 2 minutes), take out, dry, pulverize for subsequent use; Fructus Psoraleae is cleaned, and is placed in frying pan, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use;
(2) Radix Codonopsis, the Radix Aucklandiae, Radix Scrophulariae and Semen Platycladi are placed in air drier, in 90 DEG C of dryings 1.5-2 hour (preferably in 90 DEG C of dryings 1.8 hours), take out, be placed in Chinese medicine grinder and be ground into fine powder, for subsequent use;
(3) crude drug except Concha Haliotidis, Fructus Psoraleae, Radix Codonopsis, the Radix Aucklandiae, Radix Scrophulariae and Semen Platycladi is placed in medicinal cupping, adds water and do not have powder, soak 45 minutes, intense fire is heated to boil, and turns slow fire boiling twice, each each decoction 35 minutes, filter, merge twice decocting liquid, decocting liquid is condensed into thick paste;
(4) in above-mentioned thick paste, add step (1)-(2) gained fine medicinal material powder, mix homogeneously, makes pill according to the processing mode of pill, to obtain final product.
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,medicine of the present invention has Replenishing QI and nourishing YIN, the effect of the wart that disappears eliminating stagnation, tranquilizing by nourishing the heart and heat-clearing and toxic substances removing, for hyperthyroidism symptom Be very effective;
3,medicine of the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine, is prepared from by following bulk drugs, is weight portion (70g/ part): Radix Angelicae Sinensis 15 parts; Concha Haliotidis 9 parts; The Cortex Eucommiae 10 parts; Fructus Corni 10 parts; Radix Trichosanthis 10 parts; Semen Platycladi 9 parts; Rhizoma Alpiniae Officinarum 8 parts; Radix Ranunculi Ternati 6 parts; Herba Laggerae Alatae 7 parts; Rhizoma Dioscoreae 15 parts; Pericarpium Citri Reticulatae 15 parts; 6 parts, Flos Carthami; Radix Codonopsis 6 parts; Rhizoma Dioscoreae Bulbiferae 3 parts; Radix Scrophulariae 8 parts; Spica Prunellae 6 parts; The Radix Aucklandiae 15 parts; Rhizoma Atractylodis Macrocephalae 15 parts; Rhizoma Sparganii 8 parts; Fructus Psoraleae 15 parts.
The preparation method of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction is:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, is then placed in rice vinegar and quenches system 4 minutes, take out, dry, pulverizes for subsequent use; Fructus Psoraleae is cleaned, and soaks 1 hour with saline solution, takes out, dries, be placed in frying pan, add Oleum Helianthi, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use; By Concha Haliotidis powder and the mixing of Psoralen cosmetics, cross 70 mesh sieves, for subsequent use;
(2) be placed in medicine pot by clean respectively to Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae, add Zhenjiang rice vinegar and do not have powder, moderate heat heats, and decocts 5 minutes, takes out, drying for standby;
(3) crude drug except Concha Haliotidis, Fructus Psoraleae, Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae is poured in medicinal cupping, add the distilled water immersion 1 hour of 8 times of material quantities, add the crude drug that step (1) and step (2) processed, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 40 minutes, and second time decocts 25 minutes, filter, collecting decoction;
(4) above-mentioned decocting liquid is evaporated to 2/3,97 DEG C of dry heat sterilizations 15 minutes of original liquid volume, cooling, encapsulation, to obtain final product.
The instructions of taking of decoction of the present invention is: twice daily, each 170-200mL, warmly takes, 10 days courses for the treatment of.
Model case: Wei XX, female, 34 years old, people from Weihai.Patient is to our hospital on August 22nd, 2012.Patient's readme: suffer from hyperthyroidism and have a surplus for 3 years, take western medicine is always bad during state of an illness fashion.Recently because body weight obviously declines, polyphagia phenomenon is seriously come my institute and is checked.Check: patient's palpebral fissure is slightly broadening, and eyeball is slightly given prominence to, dysphoria with feverish sensation in the chest palms and soles, and body of the tongue is partially red.The 2 degree of enlargements of two thyroid, right thyroid can touch and tremble, and hears and vascular murmur.Heart circle expands to left down, heart rate 118 beats/min.Thyroid function: T
3, T
4, FT
3, FT
4obvious rising, TSH reduces.Be diagnosed as hyperthyroidism, TCM syndrome is type of deficiency of both QI and YIN.
Take the present embodiment gained hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction, instructions of taking: twice daily, each 170-200mL, warmly to take, 10 days courses for the treatment of.After treating two courses for the treatment of, patient clinical symptom and sign obviously alleviate, and continue two courses for the treatment of of medication, patient checks that first merit is tending towards normal, advises patient to continue medication and is consolidated a course for the treatment of, pay a return visit after three months, and patient fully recovers, without recurrence.
embodiment 2hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine, is prepared from by following bulk drugs, is weight portion (30g/ part): Radix Angelicae Sinensis 20 parts; Concha Haliotidis 16 parts; The Cortex Eucommiae 20 parts; Fructus Corni 14 parts; Radix Trichosanthis 20 parts; Semen Platycladi 18 parts; Rhizoma Alpiniae Officinarum 16 parts; Radix Ranunculi Ternati 9 parts; Herba Laggerae Alatae 14 parts; Rhizoma Dioscoreae 30 parts; Pericarpium Citri Reticulatae 30 parts; 12 parts, Flos Carthami; Radix Codonopsis 12 parts; Rhizoma Dioscoreae Bulbiferae 6 parts; Radix Scrophulariae 12 parts; Spica Prunellae 9 parts; The Radix Aucklandiae 20 parts; Rhizoma Atractylodis Macrocephalae 20 parts; Rhizoma Sparganii 12 parts; Fructus Psoraleae 20 parts.
The preparation method of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine granules is:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, is then placed in rice vinegar and quenches system 6 minutes, take out, dry, pulverizes for subsequent use; Rhizoma Sparganii sheet is placed in medicine pot, intense fire heat, fry to surface blackening, crisp for degree, take out, cool, pulverization is for subsequent use;
(2) Semen Platycladi is cleaned, and dries, and crushes, and with toilet paper parcel, put in frying pan, slow fire heats, and roasting is deoiled, fine ground for subsequent use; Fructus Psoraleae is cleaned, and soaks 1.5 hours with saline solution, takes out, dries, be placed in frying pan, add Oleum Helianthi, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use;
(3) by step (1)-step (2) gained fine medicinal material powder, stir, cross 70 mesh sieves, obtain mixing fine powders;
(4) cleaned respectively by the medical material except Concha Haliotidis, Rhizoma Sparganii, Semen Platycladi and Fructus Psoraleae, dry, put into medicinal cupping, the mass fraction adding 10 times of material quantities is the ethanol of 80%, airtight dipping 1.2 hours, heating and refluxing extraction twice, first time extracts 60 minutes, and second time is extracted 40 minutes, filters, merge extractive liquid, reclaims ethanol;
(5) above-mentioned gained extracting solution being evaporated to 85 DEG C of relative densities is the thick paste of 1.30-1.33; In thick paste, add step (3) gained fine powder, add sucrose, amylum pregelatinisatum and sodium cellulosate (thick paste powder: sucrose: amylum pregelatinisatum: sodium cellulosate=5:0.9:0.7:0.7), granulate, cross No. six sieves, be processed into granule, obtain final product.
The instructions of taking of granule of the present invention is: every day three times, each 30-35g, and warm water is taken after mixing it with water, 10 days courses for the treatment of.
Model case: Cui XX, man, 45 years old, people from Xuzhou.Patient is to our hospital on May 19th, 2013.Patient's readme: before 4 months without obvious inducement occur cardiopalmus, weak, become thin, the symptom such as ophthalmic bloated, when just starting, symptom is comparatively light, and do not add attention, afterwards aggravation, health is obviously become thin, spiritlessness and weakness, dizzy insomnia.Patient cannot orthobiosis and work.Under the introduction of friend, come my institute and check treatment.Check: patient's above-mentioned symptom is obvious, body temperature is normal, blood pressure 142/85mmHg, and eyes are given prominence to, the puffiness of the eyes, distension of jugular vein, thyroid 1 degree of enlargement, vascular murmur (+).Both hands are flat to be stretched tremble (+).Thyroid function: FT
3: 8.12pmol/L, FT
4: 12.67 pmol/L, TSH:0.01U/ml.Be diagnosed as hyperthyroidism, TCM syndrome is type of deficiency of both QI and YIN.
Take the present embodiment gained hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine granules, instructions of taking: every day three times, each 30-35g, warm water is taken after mixing it with water, 10 days courses for the treatment of.After taking two courses for the treatment of, the transference cures such as patient's spiritlessness and weakness, dizzy insomnia, two courses for the treatment of of continuation medication, patients symptomatic and sign disappear substantially, and thyroid function is close to normal range.Advise patient to continue medication to be consolidated a course for the treatment of, pay a return visit after three months, patient fully recovers, without recurrence.
embodiment 3hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine, is prepared from by following bulk drugs, is weight portion (60g/ part): Radix Angelicae Sinensis 17 parts; Concha Haliotidis 12 parts; The Cortex Eucommiae 13 parts; Fructus Corni 11 parts; Radix Trichosanthis 13 parts; Semen Platycladi 12 parts; Rhizoma Alpiniae Officinarum 11 parts; Radix Ranunculi Ternati 7 parts; Herba Laggerae Alatae 9 parts; Rhizoma Dioscoreae 20 parts; Pericarpium Citri Reticulatae 20 parts; 8 parts, Flos Carthami; Radix Codonopsis 8 parts; Rhizoma Dioscoreae Bulbiferae 4 parts; Radix Scrophulariae 9 parts; Spica Prunellae 7 parts; The Radix Aucklandiae 17 parts; Rhizoma Atractylodis Macrocephalae 17 parts; Rhizoma Sparganii 9 parts; Fructus Psoraleae 17 parts.
The instructions of taking of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicinal tablet is:
(1) Rhizoma Sparganii sheet is cleaned, and adding soaking in Chinese liquor 3 hours, frying Testa Tritici to smoldering simultaneously in frying pan, add the Rhizoma Sparganii sheet steeped, and moderate heat heats, and fry to yellow, sieve removes Testa Tritici, lets cool, is ground into fine powder for subsequent use; By rice in medicine pot, when moderate heat is heated to meter smoke, pour Radix Codonopsis sheet into, frying to rice is strong yellow, takes out, and sieve removes rice, cools, smashs to pieces for subsequent use;
(2) Radix Angelicae Sinensis Tabellae is placed in medicine pot, and add Shanxi mature vinegar and do not have powder 2-4cm, intense fire is heated to boil, and turns slow fire boiling 8 minutes, takes out, dry, smashs to pieces for subsequent use; Concha Haliotidis smashs into end to pieces, for subsequent use;
(3) crude drug except Rhizoma Sparganii, Radix Codonopsis, Radix Angelicae Sinensis and Concha Haliotidis is cleaned respectively, in 120 DEG C of hot air dryings 45 minutes, be then placed in Chinese medicine grinder and be ground into fine powder;
(4) by step (1)-(3) gained fine powder mixing, cross 130 mesh sieves, add magnesium stearate and dextrin (medicated powder: magnesium stearate: dextrin=5:1.1:0.9), be placed in tablet machine and be pressed into tablet, to obtain final product.
The instructions of taking of Tablets is: every day three times, each 3-5 sheet, and warm water takes, 10 days courses for the treatment of.
Model case: Cui XX, female, 46 years old, people from Zibo.Patient is to our hospital in JIUYUE in 2012 7 days.Patient's readme: nearly 2 wheat harvesting periods occur insomnia without obvious inducement, irritated, the symptoms such as night sweat.Occurred polyphagia again afterwards, symptom of becoming thin, times of defecation increases.Have a strong impact on work and life.Once in local hospital inspection, be diagnosed as nervous dysfunction at that time, once take oryzanol and vitamin B1 treatment.After treating two courses for the treatment of, do not feel any better, checked medical in get off my institute of the introduction of friend afterwards.Check: patient skin hectic fever, hands carefully quivers, blepharoedema, and the sight eyes that glitter are gently convex, and before tibia, skin increases thick, thyroid function: T
3, T
4, FT
3, FT
4obvious rising, TSH reduces.Be diagnosed as hyperthyroidism, TCM syndrome is type of deficiency of both QI and YIN.
Take the present embodiment gained hyperthyroid patient supplementing QI and nourishing YIN Chinese medicinal tablet, instructions of taking: every day three times, each 3-5 sheet, warm water takes, 10 days courses for the treatment of.Through the treatment of four courses for the treatment of, patient's first merit indices is obviously normal, and patient returns to one's perfect health.Advise patient to continue medication to be consolidated a course for the treatment of, pay a return visit after three months, patient fully recovers, without recurrence.
embodiment 4hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine, is prepared from by following bulk drugs, is weight portion (40g/ part): Radix Angelicae Sinensis 18 parts; Concha Haliotidis 13 parts; The Cortex Eucommiae 17 parts; Fructus Corni 13 parts; Radix Trichosanthis 17 parts; Semen Platycladi 15 parts; Rhizoma Alpiniae Officinarum 13 parts; Radix Ranunculi Ternati 8 parts; Herba Laggerae Alatae 12 parts; Rhizoma Dioscoreae 25 parts; Pericarpium Citri Reticulatae 25 parts; 10 parts, Flos Carthami; Radix Codonopsis 10 parts; Rhizoma Dioscoreae Bulbiferae 5 parts; Radix Scrophulariae 11 parts; Spica Prunellae 8 parts; The Radix Aucklandiae 18 parts; Rhizoma Atractylodis Macrocephalae 18 parts; Rhizoma Sparganii 11 parts; Fructus Psoraleae 18 parts.
The preparation method of hyperthyroid patient supplementing QI and nourishing YIN medicine pill is:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, is placed in yellow wine dipping 2 minutes, takes out, dry, pulverize for subsequent use; Fructus Psoraleae is cleaned, and is placed in frying pan, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use;
(2) Radix Codonopsis, the Radix Aucklandiae, Radix Scrophulariae and Semen Platycladi are placed in air drier, in 90 DEG C of dryings 1.8 hours, take out, be placed in Chinese medicine grinder and be ground into fine powder, for subsequent use;
(3) crude drug except Concha Haliotidis, Fructus Psoraleae, Radix Codonopsis, the Radix Aucklandiae, Radix Scrophulariae and Semen Platycladi is placed in medicinal cupping, adds water and do not have powder, soak 45 minutes, intense fire is heated to boil, and turns slow fire boiling twice, each each decoction 35 minutes, filter, merge twice decocting liquid, decocting liquid is condensed into thick paste;
(4) in above-mentioned thick paste, add step (1)-(2) gained fine medicinal material powder, mix homogeneously, makes pill according to the processing mode of pill, to obtain final product.
The instructions of taking of pill of the present invention is: every day three times, each 8-12 ball, and warm water is taken after mixing it with water, 10 days courses for the treatment of.
Model case: king XX, man, 53 years old, people from Jining.Patient is to our hospital on October 11st, 2013.Patient's readme: suffer from hyperthyroidism more than 2 years, worries that serious sequela appears in operative treatment, so drug administration treatment always.Take Western medicine more than a year, symptom is alleviated to some extent, but the state of an illness easily repeatedly, and bad during fashion, Mr. Wang is very worried, and the state of an illness of worrying down like this can increase the weight of, and delays better treatment.Seek Therapeutic Method safely and effectively always hard, in classmate's party, talk about the worry of oneself, have classmate to advise the treatment of my institute, Mr. Wang is had the phychology of trying in arms and is come my institute and check treatment soon.Check: patient's thyroid function: FT
4: 114.20pmol/L, FT
3: 32.5pmol/L, TSH reduce.Have vomiting video picture after patients diet, To Be Protected from Heat, spiritlessness and weakness, dizzy, thyromegaly, and not and tuberosity, without noise, the rhythm of the heart is not neat, heart circle not quite, heart rate 103 beats/min, without noise, two lower limb Mild edema.Be diagnosed as hyperthyroidism, TCM syndrome is type of deficiency of both QI and YIN.
Take the present embodiment gained hyperthyroid patient supplementing QI and nourishing YIN medicine pill, instructions of taking: every day three times, each 8-12 ball, warm water is taken after mixing it with water, 10 days courses for the treatment of.After taking two courses for the treatment of, the transference cures such as patient's spiritlessness and weakness, dizziness, continue two courses for the treatment of of medication, patients symptomatic and sign disappear substantially, and thyroid function is close to normal range.Advise patient to continue medication to be consolidated a course for the treatment of, pay a return visit after three months, patient fully recovers, without recurrence.
embodiment 5hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine, is prepared from by following bulk drugs, is weight portion (50g/ part): Radix Angelicae Sinensis 17.5 parts; Concha Haliotidis 12.5 parts; The Cortex Eucommiae 15 parts; Fructus Corni 12 parts; Radix Trichosanthis 15 parts; Semen Platycladi 13.5 parts; Rhizoma Alpiniae Officinarum 12 parts; Radix Ranunculi Ternati 7.5 parts; Herba Laggerae Alatae 10.5 parts; Rhizoma Dioscoreae 22.5 parts; Pericarpium Citri Reticulatae 22.5 parts; 9 parts, Flos Carthami; Radix Codonopsis 9 parts; Rhizoma Dioscoreae Bulbiferae 4.5 parts; Radix Scrophulariae 10 parts; Spica Prunellae 7.5 parts; The Radix Aucklandiae 17.5 parts; Rhizoma Atractylodis Macrocephalae 17.5 parts; Rhizoma Sparganii 10 parts; Fructus Psoraleae 17.5 parts.
The preparation method of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction is:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, is then placed in rice vinegar and quenches system 6 minutes 6, take out, dry, pulverizes for subsequent use; Fructus Psoraleae is cleaned, and soaks 1.5 hours with saline solution, takes out, dries, be placed in frying pan, add Oleum Helianthi, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use; By Concha Haliotidis powder and the mixing of Psoralen cosmetics, cross 100 mesh sieves, for subsequent use;
(2) be placed in medicine pot by clean respectively to Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae, add Zhenjiang rice vinegar and do not have powder, moderate heat heats, and decocts 8 minutes, takes out, drying for standby;
(3) crude drug except Concha Haliotidis, Fructus Psoraleae, Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae is poured in medicinal cupping, add the distilled water immersion 1.3 hours of 9 times of material quantities, add the crude drug that step (1) and step (2) processed, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 50 minutes, and second time decocts 30 minutes, filter, collecting decoction;
(4) above-mentioned decocting liquid is evaporated to 2/3,101 DEG C of dry heat sterilizations 20 minutes of original liquid volume, cooling, encapsulation, to obtain final product.
The instructions of taking of decoction of the present invention is: twice daily, each 170-200mL, warmly takes, 10 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Angelicae Sinensis: base is former: this product is the dry root of umbelliferae angelica.Chemical analysis: root is containing volatile oil, and Minxian County, Gansu product person contains 0.7% containing 0.4%, Si Chuanwen county product person.Volatilization main body of oil has: butylidenephthalide, the positive pentanone of adjacent carboxyl benzene and Δ 2,4-dihydro acid phthalic anhydride.Nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Cure mainly: for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Concha Haliotidis: base is former: this product is the shell of Bao Ke animal Haliotis diversicolor, haliotis discus hannai Ino, sheep Bao, haliotis ruber, Er Bao or white Bao.Nature and flavor: salty, cold.Gui Jing: return Liver Channel.Effect: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Cure mainly: dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.
The Cortex Eucommiae: base is former: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae.Character: this product be en plaque or both sides slightly toward curls inward, not of uniform size, thick 3-7mm.Outer surface light brown or taupe, have obvious wrinkle or lobe groove stricture of vagina, some barks are thinner, do not remove rough bark, visible significantly hole skin.Inner surface mulberry, smooth.Matter is crisp, frangibility, and section has fine and closely woven, silvery white, rubber thread full of elasticity to be connected.Feeble QI, taste is slightly bitter.Nature and flavor: sweet, temperature.Gui Jing: return liver, kidney channel.Effect: invigorating the liver and kidney, bone and muscle strengthening.Antiabortive.Curing mainly: for lumbago due to renal deficiency. muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Fructus Corni: base is former: this product is the drying and ripening sarcocarp of Fructus Corni English section plant Fructus Corni.Chemical analysis: containing morroniside, 7-0-methyl morroniside, sweroside, loganin, Fructus Corni tannin 1,2,3 etc.Nature and flavor: sour, puckery, tepor.Gui Jing: return liver, kidney channel.Effect: liver and kidney tonifying, essence astringing and desertion stemming.Cure mainly: for vertigo and tinnitus, soreness of waist and knee joint, sun is passed out semen repeatly, enuresis frequent micturition, bleeding not during menses, and profuse sweating is collapsed, and interior-heat is quenched one's thirst.
Radix Trichosanthis: base is former: be the root of cucurbitaceous plant Fructus Trichosanthis.Nature and flavor: sweetness and bitterness acid are cool.Gui Jing: enter lung, stomach warp.Function cures mainly: promote the production of body fluid, and quenches the thirst, and pathogenic fire reducing is moisturized, evacuation of pus, detumescence.Control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.
Semen Platycladi: base is former: this product is the dry mature kernal of Cupressaceae plant Cacumen Platycladi.Nature and flavor: sweet are flat.Gui Jing: enter the heart, liver, spleen channel.Function cures mainly: tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control palpitation with fear, insomnia, seminal emission, night sweat, constipation.Chemical analysis: the fatty oil of seed about 14%, and containing a small amount of volatile oil, Saponin.
Rhizoma Alpiniae Officinarum: base is former: be the rhizome of zingiberaceous plant Rhizoma Alpiniae Officinarum.Chemical analysis: rhizome is containing volatile oil 0.5 ~ 1.5%, and wherein main component is 1, 8-Cineole and methyl cinnamate, still has eugenol, pinene, Cadinene etc.Rhizome, still containing flavonoid galangin, kaempferol, kaempferol, Quercetin, isorhamnetin etc. and a kind of piquancy component, claims galangol.Nature and flavor: pungent, temperature.Gui Jing: enter spleen, stomach warp.Function cures mainly: stomach warming, dispels the wind, cold expelling, circulation of qi promoting, pain relieving.Control taste invasion by pathogenic cold, coldness and pain in the epigastrium, vomiting is had loose bowels, dried meat regurgitation of choking, dyspepsia, subtertian malaria, cold addiction.
Radix Ranunculi Ternati: base is former: be the tuber of Herba Ranunculi Japonici kind of plant Seynuns Kugelann.Nature and flavor: sweet, acrid, warm.Gui Jing: " Guangxi Chinese medicinal herbal ": " enter liver, lung two warp." function cures mainly: control scrofula, pulmonary tuberculosis, malaria.
Herba Laggerae Alatae: base is former: be the herb of feverfew Laggera alata (Roxb.) Sch.-Bip..Chemical analysis: containing flavonoid glycoside, phenols, organic acid, aminoacid, saccharide.Nature and flavor: pungent, temperature.Gui Jing: " east, Fujian book on Chinese herbal medicine ": " enter lung, spleen, bladder three warp." function cures mainly: dispel the wind, dehumidifying, changes stagnant, dissipating blood stasis, detumescence, removing toxic substances.Cure cold cough body pain, stomachache dysentery, rheumatic arthritis, women's amenorrhea, traumatic injury, furuncle carbuncle scrofula, noxious dampness pruritus.
Rhizoma Dioscoreae: base is former: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung, kidney channel.Effect: spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.Cure mainly: for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Pericarpium Citri Reticulatae: base is former: this product is the dry mature skin of rutaceae orange and variety thereof.Character: Pericarpium Citri Reticulatae often shells into several lobe, and base portion is connected, what have is irregular lamellar.Orange red or the rufous of outer surface, has fine wrinkle and recessed point-like grease chamber; Inner surface ivory buff, coarse, attached yellow-white or yellowish-brown grain shape vascular bundle.Nature and flavor: bitter, pungent, temperature.Gui Jing: return lung, spleen channel.Effect: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Cure mainly: for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Flos Carthami: base is former: this product is the dried floral of feverfew Flos Carthami.Character: this product is the tubular flower not with ovary.Surface red is yellow or red.Tube is elongated, and tip 5 splits, and sliver is slat shape; Flower pesticide aggregates into tubular, yellow-white; Stigma elongated cylindrical, top differential is pitched.Matter is soft.Nature and flavor: pungent, temperature.Gui Jing: GUIXIN, Liver Channel.Effect: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Cure mainly: for amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Codonopsis: base is former: the dry root that this product is Campanulaceae Radix Codonopsis, element spends Radix Codonopsis or radix codonpsis tangshen.Chemical analysis: Radix Codonopsis root is containing Saponin, Alkaloid, sucrose, glucose, inulin, starch, mucus and resin etc.Nature and flavor: sweet are flat.Gui Jing: return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Cure mainly: for deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Rhizoma Dioscoreae Bulbiferae: base is former: be the tuber of Dioscoreaceae plant Dioscorea bulbifera L..Nature and flavor: bitter are flat.Gui Jing: " Bencao Jingshu ": " start with few the moon, meridian of Foot-JUE YIN." function cures mainly: removing heat from blood, pathogenic fire reducing, disappear wart, removing toxic substances.Control haematemesis, epistaxis, sore throat, goiter, carbuncle sore scrofula.
Radix Scrophulariae: base is former: this product is the dry root of goatweed Radix Scrophulariae.Character: this product is class prop drawing shape, and centre is slightly thick or upper coarse and lower fine, some microbends.Surface lark or taupe, has irregular longitudinal furrow, hole skin sample projection of growing crosswise and sparse transverse crack and a mark of fibrous root.Nature and flavor: sweet, bitter, salty, are slightly cold.Gui Jing: return lung, stomach, kidney channel.Effect: removing heat from blood YIN nourishing, eliminating fire and detoxication.Cure mainly: for consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, and scrofula is sick, diphtheria, carbuncle sore tumefacting virus.
Spica Prunellae: base is former: this product is the dry fruit ear of labiate Spica Prunellae.Chemical analysis: herb is containing triterpenoid saponin, its glycoside unit is oleanolic acid, still containing free oleanolic acid, ursolic acid, globulariacitrin, hyperin, cis-caffeic acid, trans-caffeic acid, vitamin B1, vitamin C, vitamin K, carotene, resin, amaroid, tannin, volatile oil, alkaloid, water soluble salt (about 3.5%, wherein about 63% is potassium chloride) etc.Nature and flavor: pungent, bitter, cold.Gui Jing: return liver, gallbladder meridian.Pharmacological action: 1. hypotensive effect, 2. antibacterial action.Effect: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.Cure mainly: for conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
The Radix Aucklandiae: base is former: this product is the dry root of the feverfew Radix Aucklandiae.Chemical analysis: containing constuslactone, dihydrocostulactone, Saussurea Lactone, costunolide, dihydro costunolide etc.Nature and flavor: pungent, bitter, temperature.Gui Jing: return spleen, stomach, large intestine, three burnt, gallbladder meridians.Effect: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Cure mainly: for breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
The Rhizoma Atractylodis Macrocephalae: base is former: this product is the dry rhizome of the feverfew Rhizoma Atractylodis Macrocephalae.Chemical analysis: containing volatile oil 1.4%, main component is atractylol, atractylone etc., and containing vitamin A.Nature and flavor: bitter, sweet, temperature.Gui Jing: return spleen, stomach warp.Effect: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Cure mainly: for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Rhizoma Sparganii: base is former: be the tuber of Sparganiaceae plant rhizoma scirpi or little rhizoma scirpi, spire rhizoma scirpi.Chemical analysis: little rhizoma scirpi is containing volatile oil 0.05%.Nature and flavor: toil are flat.Gui Jing: enter liver.Spleen channel.Function cures mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Skin ulcer swells hard.
Fructus Psoraleae: base is former: be the fruit of legumes psoraleae.Chemical analysis: fruit is containing volatile oil about 20%, organic acid, a kind of methyl glucoside, alkali soluble resins, fixedness terpenoid oil, Saponin.Seed containing Coumarins psoralen and isopsorapen altogether about 1.1%, flavonoid bavachin, bavachinin, isobavachin and chalcone Bavachalcone, corylifolinin, monoterpene amphyl Bakuchiol; Still containing volatile oil, resin, fatty oil.Spend fatty oil, volatile oil, sterol, alkaloid etc.This plant is also containing Raffinose.Nature and flavor: pungent, temperature.Gui Jing: enter kidney channel.Function cures mainly: reinforcing the kidney and supporting YANG.Control cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.External curing vitiligo.
test example 1the clinical practice of gained hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine (embodiment 5) of the present invention:
1, data and method
1.1 physical data
Screen hyperthyroid patient 176 example that in May ,-2013 in October, 2011, my institute accepted for medical treatment, age is in 22-56 year, wherein male 83 example, women 93 example, all patients meet the diagnostic criteria of " Thyroid Diseases in China diagnosis and treatment guide " middle hyperthyroidism that endocrinology branch of Chinese Medical Association formulates.
1.2 Therapeutic Method
All patients are divided into treatment group and matched group at random, and two groups of patients, in sex, the state of an illness, the course of disease etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein treatment group takes gained medicine of the present invention, and matched group takes other medicine (as conventional medication such as thiamazole, Thiamazole tablets, Jiakangling Granules).Treat four courses for the treatment of altogether.
1.3 diagnostic criteria
(1) TCM syndrome (type of deficiency of both QI and YIN): spiritlessness and weakness, hectic fever night sweat, dry mouth and throat, tachypnea hyperhidrosis, dysphoria with feverish sensation in the chest palms and soles, the soft heavy sensation of the body of limb, dizzy insomnia, cardiopalmus is forgetful, body of the tongue is partially red, white and thin fur, thready and rapid pulse.
(2) Western medicine diagnose: the T of thyroid gland
3, T
4, FT
3, FT
4obvious rising, due to the feedback effect of thyroid and hypophysis axle, TSH usually reduces.
1.4 curative effect determinate standard
Cure: clinical symptoms all disappears, thyroid function recovers normal; Effective: clinical symptoms partial disappearance or obviously reduce, thyroid function takes a turn for the better to some extent; Invalid: symptom is without alleviating or increasing the weight of.
1.5 therapeutic outcome
Two groups of therapeutic outcomes are as shown in table 1.
Table 1: the therapeutic outcome for the treatment of group and matched group compares
Therapeutic effect: cure 69 examples (69%), effective 28 examples (28%), invalid 3 examples (3%), total effective rate 97%.Successful is better than matched group.
Take period self-induction symptom and physical change of spirit as shown in table 2.
Table 2: take period two groups of patients symptomatic and physical change of spirit thereof
The present invention selects primary raw material medicine in Radix Angelicae Sinensis, Concha Haliotidis, the Cortex Eucommiae, Fructus Corni, Radix Trichosanthis, Semen Platycladi, Rhizoma Alpiniae Officinarum, Radix Ranunculi Ternati, Herba Laggerae Alatae, Rhizoma Dioscoreae, Pericarpium Citri Reticulatae Flos Carthami etc. 20 to be prepared from.In side, Radix Angelicae Sinensis has to enrich blood and invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation; Concha Haliotidis suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving; The Cortex Eucommiae is used for lumbago due to renal deficiency. and muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Fructus Corni cures mainly vertigo and tinnitus, soreness of waist and knee joint; Semen Platycladi tranquilizing by nourishing the heart, loosening bowel to relieve constipation; Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting; Flos Carthami promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain; Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting etc., all medicines share, and play effect of Replenishing QI and nourishing YIN, dispersing swelling and dissipating binds altogether.After treating four courses for the treatment of, treatment group total effective rate is 97%, and matched group is only 77.6%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine, is characterized in that, is prepared from by following bulk drugs, is weight portion: Radix Angelicae Sinensis 15-20; Concha Haliotidis 9-16; Cortex Eucommiae 10-20; Fructus Corni 10-14; Radix Trichosanthis 10-20; Semen Platycladi 9-18; Rhizoma Alpiniae Officinarum 8-16; Radix Ranunculi Ternati 6-9; Herba Laggerae Alatae 7-14; Rhizoma Dioscoreae 15-30; Pericarpium Citri Reticulatae 15-30; Flos Carthami 6-12; Radix Codonopsis 6-12; Rhizoma Dioscoreae Bulbiferae 3-6; Radix Scrophulariae 8-12; Spica Prunellae 6-9; Radix Aucklandiae 15-20; Rhizoma Atractylodis Macrocephalae 15-20; Rhizoma Sparganii 8-12; Fructus Psoraleae 15-20.
2. hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Angelicae Sinensis 17-18; Concha Haliotidis 12-13; Cortex Eucommiae 13-17; Fructus Corni 11-13; Radix Trichosanthis 13-17; Semen Platycladi 12-15; Rhizoma Alpiniae Officinarum 11-13; Radix Ranunculi Ternati 7-8; Herba Laggerae Alatae 9-12; Rhizoma Dioscoreae 20-25; Pericarpium Citri Reticulatae 20-25; Flos Carthami 8-10; Radix Codonopsis 8-10; Rhizoma Dioscoreae Bulbiferae 4-5; Radix Scrophulariae 9-11; Spica Prunellae 7-8; Radix Aucklandiae 17-18; Rhizoma Atractylodis Macrocephalae 17-18; Rhizoma Sparganii 9-11; Fructus Psoraleae 17-18.
3. hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Angelicae Sinensis 17.5; Concha Haliotidis 12.5; The Cortex Eucommiae 15; Fructus Corni 12; Radix Trichosanthis 15; Semen Platycladi 13.5; Rhizoma Alpiniae Officinarum 12; Radix Ranunculi Ternati 7.5; Herba Laggerae Alatae 10.5; Rhizoma Dioscoreae 22.5; Pericarpium Citri Reticulatae 22.5; Flos Carthami 9; Radix Codonopsis 9; Rhizoma Dioscoreae Bulbiferae 4.5; Radix Scrophulariae 10; Spica Prunellae 7.5; The Radix Aucklandiae 17.5; Rhizoma Atractylodis Macrocephalae 17.5; Rhizoma Sparganii 10; Fructus Psoraleae 17.5.
4. the hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, and be then placed in rice vinegar and quench 4-8 processed minute (be preferably placed in rice vinegar quench system 6 minutes), take out, drying, pulverizes for subsequent use; Fructus Psoraleae is cleaned, and soaks 1-2 hour (preferably soaking 1.5 hours with saline solution) with saline solution, takes out, dries, be placed in frying pan, add Oleum Helianthi, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use; By Concha Haliotidis powder and the mixing of Psoralen cosmetics, sieve for subsequent use;
(2) be placed in medicine pot by clean respectively to Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae, add Zhenjiang rice vinegar and do not have powder, moderate heat heats, and decocts 5-10 minute (preferably decocting 8 minutes), takes out, drying for standby;
(3) crude drug except Concha Haliotidis, Fructus Psoraleae, Rhizoma Alpiniae Officinarum, Rhizoma Sparganii and Rhizoma Atractylodis Macrocephalae is poured in medicinal cupping, add the distilled water immersion (preferably adding the distilled water immersion of 9 times of material quantities) of 8-10 times of material quantity, add the crude drug that step (1) and step (2) processed, intense fire is heated to boil, turn slow fire boiling twice, first time decocts 40-60 minute (preferably first time decocts 50 minutes), second time decocts 25-35 minute (preferably second time decocts 30 minutes), filter, collecting decoction;
(4) above-mentioned decocting liquid is evaporated to 2/3 of original liquid volume, dry heat sterilization 15-25 minute (preferred dry heat sterilization 20 minutes), cooling, encapsulation, to obtain final product.
5. the preparation method of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction according to claim 4, is characterized in that, the middle 70-130 mesh sieve excessively of step (1) (preferred 90-110 mesh sieve excessively, mistake 100 mesh sieve be more preferably).
6. the preparation method of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction according to claim 4, it is characterized in that, in step (3), the time of distilled water immersion is 1-1.6 hour (time of preferred distilled water immersion is 1.2-1.4 hour, and the time of the distilled water immersion be more preferably is 1.3 hours).
7. the preparation method of hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine decoction according to claim 4, it is characterized in that, in step (4), the temperature of dry heat sterilization is 97-105 DEG C (temperature of preferred dry heat sterilization is 100-102 DEG C, and the temperature of the dry heat sterilization be more preferably is 101 DEG C).
8. the hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is as follows:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, and be then placed in rice vinegar and quench 4-8 processed minute (be preferably placed in rice vinegar quench system 6 minutes), take out, drying, pulverizes for subsequent use; Rhizoma Sparganii sheet is placed in medicine pot, intense fire heat, fry to surface blackening, crisp for degree, take out, cool, pulverization is for subsequent use;
(2) Semen Platycladi is cleaned, and dries, and crushes, and with toilet paper parcel, put in frying pan, slow fire heats, and roasting is deoiled, fine ground for subsequent use; Fructus Psoraleae is cleaned, and soaks 1-2 hour (preferably soaking 1.5 hours with saline solution) with saline solution, takes out, dries, be placed in frying pan, add Oleum Helianthi, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use;
(3) by step (1)-step (2) gained fine medicinal material powder, stir, cross 50-90 mesh sieve (preferred mistake 70 mesh sieve), obtain mixing fine powders;
(4) medical material except Concha Haliotidis, Rhizoma Sparganii, Semen Platycladi and Fructus Psoraleae is cleaned respectively, dry, put into medicinal cupping, the mass fraction adding 10 times of material quantities is the ethanol of 70%-90% (mass fraction preferably adding 10 times of material quantities is the ethanol of 80%), airtight dipping 1-1.4 hour (preferred airtight dipping 1.2 hours), heating and refluxing extraction twice, first time extracts 55-65 minute (preferably first time extracts 60 minutes), second time is extracted 30-50 minute (preferably second time is extracted 40 minutes), filter, merge extractive liquid, reclaims ethanol;
(5) above-mentioned gained extracting solution being evaporated to 85 DEG C of relative densities is the thick paste of 1.30-1.33; In thick paste, add step (3) gained fine powder, add sucrose, amylum pregelatinisatum and sodium cellulosate (thick paste powder: sucrose: amylum pregelatinisatum: sodium cellulosate=5:0.9:0.7:0.7), granulate, cross No. six sieves, be processed into granule, obtain final product.
9. the hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Rhizoma Sparganii sheet is cleaned, and adding soaking in Chinese liquor 2-4 hour (preferably adding soaking in Chinese liquor 3 hours), frying Testa Tritici to smoldering simultaneously in frying pan, add the Rhizoma Sparganii sheet steeped, and moderate heat heats, and fry to yellow, sieve removes Testa Tritici, lets cool, is ground into fine powder for subsequent use; By rice in medicine pot, when moderate heat is heated to meter smoke, pour Radix Codonopsis sheet into, frying to rice is strong yellow, takes out, and sieve removes rice, cools, smashs to pieces for subsequent use;
(2) Radix Angelicae Sinensis Tabellae is placed in medicine pot, and add Shanxi mature vinegar and do not have powder 2-4cm, intense fire is heated to boil, and turns slow fire boiling 6-10 minute (preferably turning slow fire boiling 8 minutes), takes out, dry, smashs to pieces for subsequent use; Concha Haliotidis smashs into end to pieces, for subsequent use;
(3) crude drug except Rhizoma Sparganii, Radix Codonopsis, Radix Angelicae Sinensis and Concha Haliotidis is cleaned respectively, in 120 DEG C of hot air drying 35-55 minutes (being preferable over 120 DEG C of hot air dryings 45 minutes), being then placed in Chinese medicine grinder and being ground into fine powder;
(4) by step (1)-(3) gained fine powder mixing, cross 110-150 mesh sieve (preferred mistake 130 mesh sieve), add magnesium stearate and dextrin (medicated powder: magnesium stearate: dextrin=5:1.1:0.9), be placed in tablet machine and be pressed into tablet, to obtain final product.
10. the hyperthyroid patient supplementing QI and nourishing YIN Chinese medicine as described in as arbitrary in claim 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Concha Haliotidis is cleaned, and is placed on smokeless intense fire, is calcined to crisp, is placed in yellow wine and floods 1-3 minute (being preferably placed in yellow wine dipping 2 minutes), take out, dry, pulverize for subsequent use; Fructus Psoraleae is cleaned, and is placed in frying pan, and slow fire heats, and fries and heaves to micro-, split and have fragrance to overflow, and take out, cool, levigation is for subsequent use;
(2) Radix Codonopsis, the Radix Aucklandiae, Radix Scrophulariae and Semen Platycladi are placed in air drier, in 90 DEG C of dry 1.5-2 hours (preferably in 90 DEG C of dryings 1.8 hours), take out, be placed in Chinese medicine grinder and be ground into fine powder, for subsequent use;
(3) crude drug except Concha Haliotidis, Fructus Psoraleae, Radix Codonopsis, the Radix Aucklandiae, Radix Scrophulariae and Semen Platycladi is placed in medicinal cupping, adds water and do not have powder, soak 45 minutes, intense fire is heated to boil, and turns slow fire boiling twice, each each decoction 35 minutes, filter, merge twice decocting liquid, decocting liquid is condensed into thick paste;
(4) in above-mentioned thick paste, add step (1)-(2) gained fine medicinal material powder, mix homogeneously, makes pill according to the processing mode of pill, to obtain final product.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557376A (en) * | 2004-01-29 | 2004-12-29 | 河北省民生医药研究所 | Medicinal composition for treating hyperthyroidism |
| CN1626220A (en) * | 2004-08-12 | 2005-06-15 | 赵立明 | Chinese herbal medicine for treating hyperthyroidism |
| KR20130071216A (en) * | 2011-12-20 | 2013-06-28 | 주식회사 진생사이언스 | Food additives comprising extract of skg showing an anti-osteoporosis |
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2015
- 2015-02-09 CN CN201510064403.7A patent/CN104587343A/en active Pending
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|---|---|---|---|---|
| CN1557376A (en) * | 2004-01-29 | 2004-12-29 | 河北省民生医药研究所 | Medicinal composition for treating hyperthyroidism |
| CN1626220A (en) * | 2004-08-12 | 2005-06-15 | 赵立明 | Chinese herbal medicine for treating hyperthyroidism |
| KR20130071216A (en) * | 2011-12-20 | 2013-06-28 | 주식회사 진생사이언스 | Food additives comprising extract of skg showing an anti-osteoporosis |
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