CN104587271A - Educational medicine suitable for children with congenital mental deficiency and preparation - Google Patents
Educational medicine suitable for children with congenital mental deficiency and preparation Download PDFInfo
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Abstract
The invention discloses an educational medicine suitable for children with congenital mental deficiency. The educational medicine is prepared mainly from the following active pharmaceutical ingredients in parts by weight: 9-15 parts of rhizoma pinellinae praeparata, 8-12 parts of radix aconiti coreani, 10-25 parts of ricepaperplant pith, 15-20 parts of fructus quisqualis, 15-20 parts of radix angelicae, 9-16 parts of radix saposhnikoviae, 6-9 parts of rhizoma picrorhizae, 6-9 parts of flatstem milkvetch seed, 15-30 parts of bamboo shavings, 15-30 parts of fructus mume, 9-18 parts of radix cynanchi paniculati, 9-16 parts of herba lycopodii, 6-9 parts of radix ligustici sinensis, 3-6 parts of sensitive plant root and 8-15 parts of stir-fried fructus aurantii. The product disclosed by the invention is prepared from pure natural plants and can be taken without worry and is suitable for children with congenital mental deficiency; the formula completely conforms to the principles of the traditional Chinese medicine and has the functions of clearing heat and relieving exterior syndrome, replenishing qi and nourishing blood, promoting intelligence and nourishing brain and the like; and the educational medicine disclosed by the invention is cheap, and the economic burden on patients can be reduced through long-term use of the medicine.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to Fructus Alpiniae Oxyphyllae medicament and preparation that a kind of suitable congenital mentally deficient children takes.
Background technology
Baby is established dysplasia in utero, comprises congenital malformation and the congenital mental retardation of morphosis exception and metabolic function exception.Congenital mental retardation comprises various chromosomal aberration and opens caused mental retardation, mental retardation caused by monogenic disease, disease of multifactorial inheritance, with the mental retardation that environment teratogen causes, as alcoholism syndrome, fetus minamata disease, lead poisoning, congenital rubella syndrome and Environmental iodine deficiency affect mental retardation caused by fetal brain development etc.Some mental retardation of newborn baby is not easily found, and just starts to show by about 3 years old, also has and needs could determine on inspection to greater age.Publication number CN 102416134 A(application number 201110411013.4) Chinese patent literature disclose a kind of medicine and preparation method for the treatment of mental retardation of children, composition have Fructus Mori 20-50, Arillus Longan 20-25, Fructus Lycii 10-18, Radix Polygalae 20-30, Radix Ginseng 2-5, Semen Armeniacae Amarum 6-15, Rhizoma Dioscoreae 20-25, Isodon ternifolius 50-80, Radix Puerariae 5-8, Concha Arcae 10-15, Pericarpium Citri Reticulatae 5-15, Radix Codonopsis 10-20, Colla cornus cervi 20-25, Colla Corii Asini 5-8, Fructus Alpiniae Oxyphyllae 20-30, Semen Cuscutae 5-10.Publication number CN 103520423 A(application number 201310469194.5) Chinese patent literature disclose a kind of Chinese medicine compositions for the treatment of mental retardation of children, crude drug has Os Draconis 20-50, Arillus Longan 20-25, Fructus Lycii 10-18, Radix Polygalae 20-25, Radix Ginseng 9-15, Semen Armeniacae Amarum 6-15, Rhizoma Dioscoreae 20-25, Isodon ternifolius 50-80, Radix Puerariae 5-8, Concha Arcae 10-15, Pericarpium Citri Reticulatae 5-15, Radix Codonopsis 10-20, Colla Plastri Testudinis 5-8, Colla cornus cervi 20-25, Colla Corii Asini 5-10, Rhizoma Acori Graminei 20-30.Publication number CN 101804133 A(application number 201010140515.3) Chinese patent literature disclose a kind ofly be used for the treatment of that development in children is slow, the Chinese medicine composition of mental retardation and preparation method thereof, be made up of raw materials such as Radix Rehmanniae Preparata, Caulis Polygoni Multiflori, Rhizoma Acori Graminei, the Cortex Eucommiae, Radix Notoginseng, Fructus Schisandrae Chinensis.
The physical and mental health of child in congenital intellectual deficiency's serious harm, its pathogenic factor is complicated, reveal any symptoms is various, intelligence low degree differs, for the treatment of this disease, can only be improved by medicine combination education and intelligent training, Chinese medicine safety, cheaply, curative effect is reliable, traditional Chinese medical science formula about this disease has, but still needs to develop the effective traditional Chinese medical science formula of determined curative effect.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of prepare simple, take Fructus Alpiniae Oxyphyllae medicament and preparation that safe suitable congenital mentally deficient children takes.
Technical scheme of the present invention is:
The Fructus Alpiniae Oxyphyllae medicament that suitable congenital mentally deficient children is taken, is prepared from primarily of following bulk drugs, is weight portion: Rhizoma Pinelliae Preparatum 9-15, Radix Aconiti Coreani 8-12, Medulla Tetrapanacis 10-25, Fructus Quisqualis 15-20, Radix Angelicae Dahuricae 15-20, Radix Saposhnikoviae 9-16, Rhizoma Picrorhizae 6-9, Semen Astragali Complanati 6-9, Caulis Bambusae In Taenia 15-30, Fructus Mume 15-30, Radix Cynanchi Paniculati 9-18, Herba Lycopodii 9-16, Rhizoma Ligustici 6-9, Radix Mimosae Pudicae 3-6, Fructus Aurantii (parched) 8-15.
In preferred scheme, Rhizoma Pinelliae Preparatum 10-14, Radix Aconiti Coreani 9-11, Medulla Tetrapanacis 15-20, Fructus Quisqualis 16-19, Radix Angelicae Dahuricae 16-19, Radix Saposhnikoviae 10-15, Rhizoma Picrorhizae 7-8, Semen Astragali Complanati 7-8, Caulis Bambusae In Taenia 20-25, Fructus Mume 20-25, Radix Cynanchi Paniculati 10-17, Herba Lycopodii 11-14, Rhizoma Ligustici 7-8, Radix Mimosae Pudicae 4-5, Fructus Aurantii (parched) 10-13.
Be more preferably, Rhizoma Pinelliae Preparatum 12, Radix Aconiti Coreani 10, Medulla Tetrapanacis 17.5, Fructus Quisqualis 17.5, the Radix Angelicae Dahuricae 17.5, Radix Saposhnikoviae 12.5, Rhizoma Picrorhizae 7.5, Semen Astragali Complanati 7.5, Caulis Bambusae In Taenia 22.5, Fructus Mume 22.5, Radix Cynanchi Paniculati 13.5, Herba Lycopodii 12.5, Rhizoma Ligustici 7.5, Radix Mimosae Pudicae 4.5, Fructus Aurantii (parched) 11.5.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament decoction that described suitable congenital mentally deficient children is taken is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry and pulverize, obtained medicated powder;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, turn little fire decoct 30-50 minute (preferred, turn a little fire and decoct 35-45 minute; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(5) step (4) remaining filtering residue is added water, after ebuillition of heated, little fire decocts 20-30 minute (preferably, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate and merge with step (4) made filtrate, join in filtrate by step (3) made medicated powder, heated and stirred is even, obtains decoction.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament decoction that described suitable congenital mentally deficient children is taken, doubly (preferred, the 7-8 that amount of water is boiled crude drug quality is doubly for the 6-9 that step (4) amount of water is boiled crude drug quality; Be more preferably, amount of water is 7.5 times of boiled crude drug quality).
The preparation method of described granule is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry and pulverize, obtained medicated powder;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, turn little fire decoct 30-50 minute (preferred, turn a little fire and decoct 35-45 minute; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(5) added water by step (4) remaining filtering residue, after ebuillition of heated, little fire is decocted 20-30 minute (preferred, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate and merge with step (4) made filtrate, heating is concentrated into thick paste, and mix with step (3) made medicated powder, spraying dry, adds gelatinized corn starch and sucrose, soft material processed, granulate, 70 DEG C of dryings, granulate, obtains granule.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament granule that described suitable congenital mentally deficient children is taken, step (5) was granulated 12-16 mesh sieve (preferred, 14 mesh sieves of granulating).
The preparation method of described syrup is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) be placed in marmite by except Herba Lycopodii other crude drug except Rhizoma Picrorhizae together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, a turn little fire decocts 30-50 minute, and (preferred, 35-45 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(4) step (3) remaining filtering residue is added water, after ebuillition of heated, little fire decocts 20-30 minute (preferably, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate also to merge with step (3) made filtrate, heat and be concentrated into 1/3rd of original volume, add sucrose and aromatic and be stirred to and dissolve completely, filter, obtain syrup.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament syrup that described suitable congenital mentally deficient children is taken, in step (4) made syrup, the content of sucrose is that 45-60g/ml(is preferred, and in made syrup, the content of sucrose is 52g/ml).
The preparation method of described powder is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, a turn little fire decocts 30-50 minute, and (preferred, 35-45 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(5) step (4) remaining filtering residue is added water, after ebuillition of heated, little fire decocts 20-30 minute (preferably, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate and merge with step (4) made filtrate, spraying dry, obtaining dry thing, pulverize and sieve together with sucrose with step (3) made crude drug, obtain powder.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament powder that described suitable congenital mentally deficient children is taken, step (5) was pulverized 120-180 mesh sieve and (preferably, was pulverized 140-160 mesh sieve; Be more preferably, pulverized 150 mesh sieves).
The Fructus Alpiniae Oxyphyllae medicament scientific composition that suitable congenital mentally deficient children provided by the invention is taken, safe without toxic side effect, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, product of the present invention is that pure natural plant is made, can relievedly take, and is applicable to congenital mentally deficient children;
2, this prescription meets Chinese medicine principle completely, has clearing away heat and expelling pathogen in the exterior, benefiting QI and nourishing blood, Fructus Alpiniae Oxyphyllae support the effects such as brain;
3, cost of the present invention is cheap, and long-term taking can alleviate patient economy burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the Fructus Alpiniae Oxyphyllae medicament that suitable congenital mentally deficient children is taken, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Pinelliae Preparatum 9 parts, Radix Aconiti Coreani 8 parts, Medulla Tetrapanacis 10 parts, Fructus Quisqualis 15 parts, the Radix Angelicae Dahuricae 15 parts, Radix Saposhnikoviae 9 parts, Rhizoma Picrorhizae 6 parts, Semen Astragali Complanati 6 parts, Caulis Bambusae In Taenia 15 parts, Fructus Mume 15 parts, Radix Cynanchi Paniculati 9 parts, Herba Lycopodii 9 parts, Rhizoma Ligustici 6 parts, Radix Mimosae Pudicae 3 parts, Fructus Aurantii (parched) 8 parts.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament decoction that above-mentioned suitable congenital mentally deficient children is taken is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry and pulverize, obtained medicated powder;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, add as the water soaking of boiled crude drug quality 7.5 times after 40 minutes, be heated to boiling, turn little fire and decoct 40 minutes, filter, collect filtrate, filtering residue is for subsequent use;
(5) added water by step (4) remaining filtering residue, after ebuillition of heated, little fire decocts 25 minutes, filters, and collects filtrate and merges with step (4) made filtrate, joining in filtrate by step (3) made medicated powder, and heated and stirred is even, obtains decoction.
embodiment 2the Fructus Alpiniae Oxyphyllae medicament that suitable congenital mentally deficient children is taken, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Pinelliae Preparatum 15 parts, Radix Aconiti Coreani 12 parts, Medulla Tetrapanacis 25 parts, Fructus Quisqualis 20 parts, the Radix Angelicae Dahuricae 20 parts, Radix Saposhnikoviae 16 parts, Rhizoma Picrorhizae 9 parts, Semen Astragali Complanati 9 parts, Caulis Bambusae In Taenia 30 parts, Fructus Mume 30 parts, Radix Cynanchi Paniculati 18 parts, Herba Lycopodii 16 parts, Rhizoma Ligustici 9 parts, Radix Mimosae Pudicae 6 parts, Fructus Aurantii (parched) 15 parts.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament granule that suitable congenital mentally deficient children is taken is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry and pulverize, obtained medicated powder;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, turn little fire and decoct 40 minutes, filter, collect filtrate, filtering residue is for subsequent use;
(5) added water by step (4) remaining filtering residue, after ebuillition of heated, little fire decocts 25 minutes, filters, collect filtrate and merge with step (4) made filtrate, heating is concentrated into thick paste, and mixes with step (3) made medicated powder, spraying dry, add gelatinized corn starch and sucrose, soft material processed, 14 mesh sieves of granulating, 70 DEG C of dryings, granulate, obtains granule.
Model case: xxx, man, 3 years old.Father and mother find child's growth promoter child all more of the same age evening, walk so far unstable, can say ten words, simple instruction can be understood, comparatively quiet at ordinary times, just during upper kindergarten, teacher finds that child is absent minded, can not well play with other child, suggestion father and mother do intelligence diagnosis to child, medical check, find that child's cerebellum has mild malformation, other health indices are all normal, link up and understand child and to grow up situation, be diagnosed as congenital intellectual deficiency with father and mother.
Take the present embodiment gained and be suitable for the Fructus Alpiniae Oxyphyllae medicament granule that congenital mentally deficient children takes, each one bag of about 4g, every day 3 times, warm boiled water, 25 days courses for the treatment of.After taking three courses for the treatment of, child's attention is concentrated comparatively before, and skin takes three courses for the treatment of again, the thought of the expression oneself that child can be basic, and Gene analysis measures the front raising 9 points of comparatively treatment.After take medicine always.
embodiment 3the Fructus Alpiniae Oxyphyllae medicament that suitable congenital mentally deficient children is taken, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Pinelliae Preparatum 10 parts, Radix Aconiti Coreani 9 parts, Medulla Tetrapanacis 15 parts, Fructus Quisqualis 16-part, the Radix Angelicae Dahuricae 16 parts, Radix Saposhnikoviae 10 parts, Rhizoma Picrorhizae 7 parts, Semen Astragali Complanati 7 parts, Caulis Bambusae In Taenia 20 parts, Fructus Mume 20 parts, Radix Cynanchi Paniculati 10 parts, Herba Lycopodii 11 parts, Rhizoma Ligustici 7 parts, Radix Mimosae Pudicae 4 parts, Fructus Aurantii (parched) 10 parts.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament syrup that suitable congenital mentally deficient children is taken is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) be placed in marmite by except Herba Lycopodii other crude drug except Rhizoma Picrorhizae together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, turn little fire and decoct 40 minutes, filter, collect filtrate, filtering residue is for subsequent use;
(4) step (3) remaining filtering residue is added water, after ebuillition of heated, little fire decocts 25 minutes, filter, collect filtrate and merge with step (3) made filtrate, heating is concentrated into 1/3rd of original volume, add sucrose and aromatic to be stirred to and to dissolve completely, filter, obtain syrup (in made syrup, the content of sucrose is 52g/ml).
Model case: xxx, female, 8 months.Have jaundice when child is born, just disappear completely through three months jaundice, difficulty of sucking the breast, sob is thin and delicate, reactive poor to external world, body weight increase is comparatively slow, and body is long to be increased slowly, recently there is constipation, medical check, be diagnosed as congenita thyroaplasia with congenital intellectual deficiency.
Take the present embodiment gained be suitable for Fructus Alpiniae Oxyphyllae medicament syrup that congenital mentally deficient children takes and give thyroxine, the made syrup of the present invention adopts every day 3 times, each 4-5ml, with warm boiled water, and 25 days courses for the treatment of.After taking two courses for the treatment of, infant spirit improve, appetite increase, constipation improve, hydrouria, after taking four courses for the treatment of, infant language and activity increase, and can imitate sound, after take medicine always.
embodiment 4the Fructus Alpiniae Oxyphyllae medicament that suitable congenital mentally deficient children is taken, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Pinelliae Preparatum 14 parts, Radix Aconiti Coreani 11 parts, Medulla Tetrapanacis 20 parts, Fructus Quisqualis 19 parts, the Radix Angelicae Dahuricae 19 parts, Radix Saposhnikoviae 15 parts, Rhizoma Picrorhizae 8 parts, Semen Astragali Complanati 8 parts, Caulis Bambusae In Taenia 25 parts, Fructus Mume 25 parts, Radix Cynanchi Paniculati 17 parts, Herba Lycopodii 14 parts, Rhizoma Ligustici 8 parts, Radix Mimosae Pudicae 5 parts, Fructus Aurantii (parched) 13 parts.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament powder that suitable congenital mentally deficient children is taken is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, are heated to boiling, turn little fire and decoct 40 minutes, filter, collect filtrate, filtering residue is for subsequent use;
(5) added water by step (4) remaining filtering residue, after ebuillition of heated, little fire decocts 25 minutes, filters, collect filtrate and merge with step (4) made filtrate, spraying dry, obtaining dry thing, pulverize 150 mesh sieves with step (3) made crude drug together with sucrose, obtain powder.
Model case: xxx, man, 3 years old.Can sit during infant 10 months, one-year-old half can be stood, and growth promoter compared with normal child of the same age wants evening, only can say simple several word, can understand simple instruction, but cannot ask simple question, regardless of subject-predicate language when 2 years old.All day is comparatively quiet, seldom cries and screams, household think in child to, but to play with it, child's attitude is comparatively tranquil, and father and mother feel child's psychological problem, medical check, do not know that oneself is conceived when mother's private prosecution is conceived in early days, once took contraceptive, and be finally diagnosed as congenital intellectual deficiency.
Take the present embodiment gained and be suitable for the Fructus Alpiniae Oxyphyllae medicament powder that congenital mentally deficient children takes, adopt every day 3 times, each one bag (about 4g), with warm boiled water, 25 days courses for the treatment of.After taking three courses for the treatment of, infant personality comparatively before active, language performance comparatively before smooth and easy, after taking five courses for the treatment of, infant is grown quotient and is increased 15, can the thought of normal expression oneself.
embodiment 5the Fructus Alpiniae Oxyphyllae medicament that suitable congenital mentally deficient children is taken, is prepared from (every part of 10g) primarily of following bulk drugs: Rhizoma Pinelliae Preparatum 12 parts, Radix Aconiti Coreani 10 parts, Medulla Tetrapanacis 17.5 parts, Fructus Quisqualis 17.5 parts, the Radix Angelicae Dahuricae 17.5 parts, Radix Saposhnikoviae 12.5 parts, Rhizoma Picrorhizae 7.5 parts, Semen Astragali Complanati 7.5 parts, Caulis Bambusae In Taenia 22.5 parts, Fructus Mume 22.5 parts, Radix Cynanchi Paniculati 13.5 parts, Herba Lycopodii 12.5 parts, Rhizoma Ligustici 7.5 parts, Radix Mimosae Pudicae 4.5 parts, Fructus Aurantii (parched) 11.5 parts.
The preparation method of the Fructus Alpiniae Oxyphyllae medicament decoction that suitable congenital mentally deficient children is taken is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry and pulverize, obtained medicated powder;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, add as the water soaking of boiled crude drug quality 7.5 times after 40 minutes, be heated to boiling, turn little fire and decoct 40 minutes, filter, collect filtrate, filtering residue is for subsequent use;
(5) added water by step (4) remaining filtering residue, after ebuillition of heated, little fire decocts 25 minutes, filters, and collects filtrate and merges with step (4) made filtrate, joining in filtrate by step (3) made medicated powder, and heated and stirred is even, obtains decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Pinelliae Preparatum: base is former: be the Preparation process product of the Rhizoma Pinelliae.Get the clean Rhizoma Pinelliae, size separately, is soaked in water to interior without the dry heart, takes out; Another extracting liquorice is appropriate, decocts with water secondary, collecting decoction, pour in the lime liquor made by suitable quantity of water, stir evenly, add the above-mentioned Rhizoma Pinelliae soaked into, soak, stir 1 ~ 2 every day, and keep immersion pH value more than 12, to section yellow homogeneous, mouth is tasted micro-when having a numb feeling in the tongue, takes out, cleans, dry in the shade or dry, to obtain final product.Nature and flavor: pungent, warm.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.
Radix Aconiti Coreani: base is former: be the tuber of Ranunculaceae aconitum plant Radix Aconiti Coreani.Nature and flavor: pungent, sweet, greatly temperature.Poisonous.Function cures mainly: dispel the wind expectorant, by cold-damp.For migraine and general headache, arthralgia due to cold-dampnes, facial hemiparalysis.
Medulla Tetrapanacis: base is former: be the dry stem pith of Araliaceae rice-paper plant.Nature and flavor: sweet, light, are slightly cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting diuresis, ventilation stimulating milk secretion.For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.
Fructus Quisqualis: base is former: be the dry mature fruit of Combretum Racemosum plant Fructus Quisqualis.Nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: killing insect and eliminating accumulation.For ascarid, enterobiasis, abdominal pain due to worm stagnation, infantile malnutrition.
The Radix Angelicae Dahuricae: base is former: be the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae.Nature and flavor: pungent, temperature.Gui Jing: return stomach, large intestine, lung meridian.Function cures mainly: loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Saposhnikoviae: base is former: be the dry root of umbelliferae Saposhnikovia divaricata.Nature and flavor: acrid, sweet, warm.Gui Jing: return bladder, liver, spleen channel.Function cures mainly: inducing diaphoresis to dispel wind, and victory is wet, relieving convulsion.For headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Rhizoma Picrorhizae: base is former: be the dry rhizome of goatweed Rhizoma Picrorhizae.Nature and flavor: bitter, cold.Gui Jing: return liver, stomach, large intestine channel.Function cures mainly: clearing away damp-heat, and except hectic fever due to YIN-deficiency, disappear infantile malnutrition with fever.For damp-heat dysentery, jaundice, haemorrhoids, osteopyrexia and fever, children's's infantile malnutrition with fever.
Semen Astragali Complanati: base is former: be the seed of leguminous plant astragatus complanatus or Seem Astragali.Nature and flavor: sweet, temperature.Gui Jing: return liver, kidney channel.Function cures mainly: temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, improving eyesight.For lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision.
Caulis Bambusae In Taenia: base is former: be the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Nature and flavor: sweet, are slightly cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.
Fructus Mume: base is former: be the dry almost ripe fruit of rose department plant plum.Nature and flavor: sour, puckery are flat.Gui Jing: return liver, spleen, lung, large intestine channel.Function cures mainly: astringe the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.
Radix Cynanchi Paniculati: base is former: be the dry root and rhizome of asclepiadaceae Cynanchum plant Radix Cynanchi Paniculati.Nature and flavor: pungent, temperature.Gui Jing: return liver, stomach warp.Function cures mainly: removing dampness of dispeling the wind, antalgesic-antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, injury from falling down, urticaria, eczema.
Herba Lycopodii: base is former: be the dry herb of lycopsid Lycopodium clavatum.Nature and flavor: micro-hardship, pungent, temperature.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Rhizoma Ligustici: base is former: be rhizome and the root of samphire Rhizoma Ligustici or Rhizoma Ligustici, fiery Rhizoma Ligustici.Nature and flavor: pungent, temperature.Gui Jing: return urinary bladder channel.Function cures mainly: dispel the wind, cold expelling, dehumidifying, pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatism podomere arthralgia pain.
Radix Mimosae Pudicae: base is former: be the root of leguminous plant Herba Mimosae Pudicae.Nature and flavor: " Yunnan Chinese herbal medicine ": " puckery micro-hardship, temperature, poisonous." function cures mainly: relieving cough and resolving phlegm, dampness removing dredging collateral, stomach function regulating, removing food stagnancy.Control chronic bronchitis, rheumatalgia, chronic gastritis, infantile dyspepsia.
Fructus Aurantii (parched): base is former: be the dry immature fruit of rutaceae Citrus aurantium Linn. and variety thereof.Get wheat bran to be spread in hot pot, when yellow skin of waiting is smoldered, add Fructus Aurantii sheet, fry to faint yellow, take out, sieve removes wheat bran, cools.Nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
test example 1gained of the present invention is suitable for Fructus Alpiniae Oxyphyllae medicament (embodiment 5) impact on learning and memory of little mouse that congenital mentally deficient children takes and tests
Experimental subject: healthy mice 120, body weight about 20 grams, each half of male and female, is divided into 6 groups at random, i.e. pathological model group, of the present invention group of low dose group, high dose group of the present invention, matched group, ginseng Testudinis oral liquor for spleen and kidney low dose group, high dose group, often organizes 20.
Experiment equipment: diving tower reflective box is the wooden (-packing) case of 20cm × 20cm × 30cm, and bottom is provided with copper grid, is connected with 36v electric current, the built-in high 4.5cm of case, diameter are that the place of safety of shocking by electricity escaped by the valve rubber of 5cm as mice.
Keep away the iron case that dark reflective box is 40cm × 20cm × 20, be divided into bright and darkroom, have copper grid bottom darkroom, pass to 36v electric current, have a diameter to be the passage of 3cm between two Room, bright room is the place of safety that animal avoids electric shock.
Experimental technique: matched group injecting normal saline every day, its excess-three group nape every day portion injection of d-galactose 140mg/kg, totally six weeks, modeling is after 2 weeks, to matched group and pathological model group mouse gavaging distilled water, to the medicament of the present invention of of the present invention group of mouse gavaging various dose, every day 3 times, each 10ml and 20ml, continuous 30 days, ginseng Testudinis oral liquor for spleen and kidney is gavaged, every day 3 times to ginseng Testudinis oral liquor for spleen and kidney group, each 10ml and 20ml, continuous 30 days.After four groups of mices are gavaged for the last time, train, train and test after one time 24 hours.Observe and measure respectively organizes the learning and memory function of mice.Result compares group difference through t inspection.
1, Jumping test: during training, is placed on case endoadaptation after 3 minutes, then galvanization at the bottom of case by mice, can jump onto platform to hide noxious stimulation during mice normal reaction.Record energising jumps off electric shock number of times and errors number, as school grade from platform in 5 minutes.Then carry out official testing after 24 hours, recording in 5 minutes and jumping off the number of times that platform shocked by electricity is errors number, as Memory result.
2, step-through test: the incubation period i.e. first time that record test small mouse pierces darkroom pierce darkroom before time and 5 minutes in pierce the number of times in darkroom as observation index.Experimental result as shown in Table 1 and Table 2
The comparison of table 1 four groups of learning and memory of little mouse functions
Note: ， ﹡ p < 0.005 ， ﹟ p < 0.01 compared with pathological model group
Table 2 mice study latent time
Note: ， ﹡ p < 0.005 ， ﹟ p < 0.01 compared with pathological model group
As can be seen from Table 1 and Table 2, pathological model group is not compared with doing the matched group of any process, learning and memory errors number showed increased, and in step-through test, the incubation period of matched group is 187.46s, the incubation period of pathological model group is only 70.23s, the incubation period of its learning and memory visible obviously shortens, significant difference (﹡ p < 0.005 is had) compared with matched group, of the present invention group compared with pathological model group, learning and memory errors number obviously reduces, keep away and obviously extend dark incubation period, illustrate that products made thereby of the present invention can promote intelligence, alleviate intellectual damage.
For verifying that gained of the present invention is suitable for the therapeutic effect of the Fructus Alpiniae Oxyphyllae medicament decoction (embodiment 5) that congenital mentally deficient children is taken, because this has been clinical verification further.
test example 2gained of the present invention is suitable for the clinical practice of the Fructus Alpiniae Oxyphyllae medicament (embodiment 5) that congenital mentally deficient children is taken:
Physical data: in January ,-2014 in January, 2012, screens 345 examples and is diagnosed as congenital amential infant, wherein women 147 example, male 198 example, 12 months-36 months age, 23 ± 2 months mean aves in 4 hospital's Child Healthcare Dept. intelligence survey outpatient services.173 examples that what wherein mild mental was low have, moderate mental retardation have 112 examples, severe mental retardation have 60 examples.Diagnostic criteria: the diagnostic criteria meeting mental retardation in " Nervous System Disease of Children Preclinic and clinic ".Mental retardation degree evaluation scale: Gesell developmental scale is made a definite diagnosis, Gene analysis DQ 55-75 divides: mild mental is low; DQ 40-54 divides: moderate mental retardation; DQ 25-39 divides: severe mental retardation; DQ < 25 points: pole severe mental retardation.
Inclusive criteria: the congenital heredity metabolic diseases such as (1) congenital malformation, chromosome disease, Inherited Metabolic Disorders, autism; (2) age 1-3 year; (3) head of a family's informed consent.
Patient is divided into two groups at random, experimental group and matched group, two groups in sex, age, the course of disease, Gene analysis DQ etc. without significant difference (P > 0.05), there is comparability.Experimental group takes products obtained therefrom of the present invention, taken three times a day, each 30-40ml(adjusts to some extent depending on concrete condition), 25 days courses for the treatment of, matched group takes other medicine (joining the conventional medication such as Testudinis oral liquor for spleen and kidney, smart tuckahoe oral liquid, compound recipe Zinc, Iron, Calcium oral administration solution).Period in a medicine gives two groups of infant intelligent trainings (speech training) and Continuous Observation, measures the DQ value of two groups of every infants before and after record treatment according to Gesell developmental scale.
Curative effect situation criterion: effective: after treatment, DQ value increases by more than 10 points than before treatment; Effective: DQ value increases 5-9 and divides; Invalid: within increasing by 5 points.
Two groups of patient treatment outcome after half a year treated by table 3
Two groups of therapeutic outcomes are as shown in table 3, known from result, and have 81 examples (41.5%) infant to grow quotient in experimental group and improve more than 10 points, have the growth quotient of 106 examples (54.4%) infant to rise to 5-9 and divide, the total effective rate of experimental group is 95.9%; In matched group, treating effective has 34 examples (22.7%) infant, and treatment effectively has 68 examples (45.3%) infant, and the total effective rate of matched group is 68%.Relatively two groups of treated effects are known, and the therapeutic effect of experimental group is obviously better than matched group.
The Rhizoma Pinelliae Preparatum of drying dampness to eliminate phlegm is have selected in the present invention; The Medulla Tetrapanacis of clearing away heat and promoting diuresis; The Fructus Quisqualis of killing insect and eliminating accumulation; The Radix Angelicae Dahuricae of understand things pain-stopping; The Radix Saposhnikoviae of inducing diaphoresis to dispel wind; The Rhizoma Picrorhizae of clearing away damp-heat; The Semen Astragali Complanati of temperature compensation Liver and kidney; The Caulis Bambusae In Taenia of removing heat-phlegm; Dispel the wind the Radix Cynanchi Paniculati of removing dampness; The Herba Lycopodii of relaxing muscles and tendons and activating QI and blood in the collateral; The Rhizoma Ligustici of expelling wind and cold; The Radix Mimosae Pudicae of dampness removing dredging collateral; The Fructus Aurantii (parched) of regulating the flow of QI to ease the stomach, plays clearing away heat and expelling pathogen in the exterior altogether, benefiting QI and nourishing blood, Fructus Alpiniae Oxyphyllae supports the effects such as brain.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. be suitable for the Fructus Alpiniae Oxyphyllae medicament that congenital mentally deficient children is taken, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Rhizoma Pinelliae Preparatum 9-15, Radix Aconiti Coreani 8-12, Medulla Tetrapanacis 10-25, Fructus Quisqualis 15-20, Radix Angelicae Dahuricae 15-20, Radix Saposhnikoviae 9-16, Rhizoma Picrorhizae 6-9, Semen Astragali Complanati 6-9, Caulis Bambusae In Taenia 15-30, Fructus Mume 15-30, Radix Cynanchi Paniculati 9-18, Herba Lycopodii 9-16, Rhizoma Ligustici 6-9, Radix Mimosae Pudicae 3-6, Fructus Aurantii (parched) 8-15.
2. the Fructus Alpiniae Oxyphyllae medicament being suitable for congenital mentally deficient children and taking as claimed in claim 1, it is characterized in that, Rhizoma Pinelliae Preparatum 10-14, Radix Aconiti Coreani 9-11, Medulla Tetrapanacis 15-20, Fructus Quisqualis 16-19, Radix Angelicae Dahuricae 16-19, Radix Saposhnikoviae 10-15, Rhizoma Picrorhizae 7-8, Semen Astragali Complanati 7-8, Caulis Bambusae In Taenia 20-25, Fructus Mume 20-25, Radix Cynanchi Paniculati 10-17, Herba Lycopodii 11-14, Rhizoma Ligustici 7-8, Radix Mimosae Pudicae 4-5, Fructus Aurantii (parched) 10-13 is (preferred, Rhizoma Pinelliae Preparatum 12, Radix Aconiti Coreani 10, Medulla Tetrapanacis 17.5, Fructus Quisqualis 17.5, the Radix Angelicae Dahuricae 17.5, Radix Saposhnikoviae 12.5, Rhizoma Picrorhizae 7.5, Semen Astragali Complanati 7.5, Caulis Bambusae In Taenia 22.5, Fructus Mume 22.5, Radix Cynanchi Paniculati 13.5, Herba Lycopodii 12.5, Rhizoma Ligustici 7.5, Radix Mimosae Pudicae 4.5, Fructus Aurantii (parched) 11.5).
3. the Fructus Alpiniae Oxyphyllae medicament that the suitable congenital mentally deficient children as described in as arbitrary in claim 1-2 is taken, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry and pulverize, obtained medicated powder;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, turn little fire decoct 30-50 minute (preferred, turn a little fire and decoct 35-45 minute; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(5) step (4) remaining filtering residue is added water, after ebuillition of heated, little fire decocts 20-30 minute (preferably, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate and merge with step (4) made filtrate, join in filtrate by step (3) made medicated powder, heated and stirred is even, obtains decoction.
4. the preparation method being suitable for the Fructus Alpiniae Oxyphyllae medicament decoction that congenital mentally deficient children is taken as claimed in claim 3, is characterized in that, doubly (preferred, the 7-8 that amount of water is boiled crude drug quality doubly for the 6-9 that step (4) amount of water is boiled crude drug quality; Be more preferably, amount of water is 7.5 times of boiled crude drug quality).
5. the Fructus Alpiniae Oxyphyllae medicament that the suitable congenital mentally deficient children as described in as arbitrary in claim 1-2 is taken, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry and pulverize, obtained medicated powder;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, turn little fire decoct 30-50 minute (preferred, turn a little fire and decoct 35-45 minute; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(5) added water by step (4) remaining filtering residue, after ebuillition of heated, little fire is decocted 20-30 minute (preferred, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate and merge with step (4) made filtrate, heating is concentrated into thick paste, and mix with step (3) made medicated powder, spraying dry, adds gelatinized corn starch and sucrose, soft material processed, granulate, 70 DEG C of dryings, granulate, obtains granule.
6. the preparation method of Fructus Alpiniae Oxyphyllae medicament granule taken of congenital mentally deficient children as claimed in claim 5 suitable, is characterized in that, step (5) was granulated 12-16 mesh sieve (preferred, 14 mesh sieves of granulating).
7. the Fructus Alpiniae Oxyphyllae medicament that the suitable congenital mentally deficient children as described in as arbitrary in claim 1-2 is taken, it is characterized in that, be made into pharmaceutically acceptable syrup, its preparation method is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) be placed in marmite by except Herba Lycopodii other crude drug except Rhizoma Picrorhizae together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, a turn little fire decocts 30-50 minute, and (preferred, 35-45 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(4) step (3) remaining filtering residue is added water, after ebuillition of heated, little fire decocts 20-30 minute (preferably, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate also to merge with step (3) made filtrate, heat and be concentrated into 1/3rd of original volume, add sucrose and aromatic and be stirred to and dissolve completely, filter, obtain syrup.
8. the preparation method being suitable for the Fructus Alpiniae Oxyphyllae medicament syrup that congenital mentally deficient children is taken as claimed in claim 7, it is characterized in that, in step (4) made syrup, the content of sucrose is that 45-60g/ml(is preferred, and in made syrup, the content of sucrose is 52g/ml).
9. the Fructus Alpiniae Oxyphyllae medicament that the suitable congenital mentally deficient children as described in as arbitrary in claim 1-2 is taken, it is characterized in that, be made into pharmaceutically acceptable powder, its preparation method is:
(1) get Adeps caprae seu ovis and put heat fused in pot, remove slag, the more micro-stir-fry of the Herba Lycopodii adding impurity, substantially exhaust to Adeps caprae seu ovis, taking-up cools;
(2) get Rhizoma Zingiberis Recens, smash to pieces, add water a little, squeezing extracting juice, Sucus Zingberis is spilt on the Rhizoma Picrorhizae of section, mix thoroughly, with the micro-stir-fry of little fire, take out, dry;
(3) by Fructus Quisqualis, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Fructus Mume and Fructus Aurantii (parched) decontamination, clean, dry;
(4) Rhizoma Pinelliae Preparatum, Radix Aconiti Coreani, Medulla Tetrapanacis, Semen Astragali Complanati, Caulis Bambusae In Taenia, Radix Cynanchi Paniculati, Rhizoma Ligustici, Radix Mimosae Pudicae are placed in marmite together with step (1) (2) made crude drug, after soaking 40 minutes, be heated to boiling, a turn little fire decocts 30-50 minute, and (preferred, 35-45 minute decocted by a turn little fire; Be more preferably, turn little fire and decoct 40 minutes), filter, collect filtrate, filtering residue is for subsequent use;
(5) step (4) remaining filtering residue is added water, after ebuillition of heated, little fire decocts 20-30 minute (preferably, after ebuillition of heated, little fire decocts 25 minutes), filter, collect filtrate and merge with step (4) made filtrate, spraying dry, obtaining dry thing, pulverize and sieve together with sucrose with step (3) made crude drug, obtain powder.
10. the preparation method being suitable for the Fructus Alpiniae Oxyphyllae medicament powder that congenital mentally deficient children is taken as claimed in claim 9, is characterized in that, step (5) was pulverized 120-180 mesh sieve and (preferably, pulverized 140-160 mesh sieve; Be more preferably, pulverized 150 mesh sieves).
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