CN104587142A - Medicine composition for treating chronic gastritis - Google Patents
Medicine composition for treating chronic gastritis Download PDFInfo
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- CN104587142A CN104587142A CN201510080023.2A CN201510080023A CN104587142A CN 104587142 A CN104587142 A CN 104587142A CN 201510080023 A CN201510080023 A CN 201510080023A CN 104587142 A CN104587142 A CN 104587142A
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Abstract
The invention relates to a medicine composition for treating chronic gastritis. The medicine composition is prepared from the following raw materials in parts by weight: 30 to 50 parts of ludwigia prostrata, 30 to 80 parts of twocolor magnoliavine root and stem, 40 to 50 parts of laevigate parameria stem, 30 to 50 parts of aconitum brachypodum, 40 to 50 parts of scandent schefflera stems and leaves, 40 to 60 parts of Szechwan raspberries, 30 to 50 parts of ligusticum brachylobum, 40 to 50 parts of morinda officinalis, 30 to 50 parts of French marigold, 30 to 50 parts of ceratopteris thalictroides, 40 to 60 parts of inula cappa, 30 to 40 parts of downy aletris, 40 to 50 parts of Chinese hibisci rosae-sinensis flowers, 30 to 50 parts of Indian lettuce, 30 to 50 parts of elaeagnus pungens, 20 to 50 parts of Japanese white birch barks, 20 to 50 parts of ziziphora clinopodioides lam, 30 to 50 parts of lombardy poplar, 20 to 50 parts of nude pronephrium rhizome and 30 to 40 parts of licorice. According to the medicine composition, the medicines are combined, the formula is reasonable, both symptoms and root causes are treated, and remarkable therapeutic effects of regulating qi and blood, regulating qi to promote blood circulation and dredging collaterals to promote the circulation of qi to relieve pain are achieved.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of pharmaceutical composition for the treatment of chronic gastritis.
Background technology
Chronic gastritis (CG) is the chronic gastric mucosal inflammatory pathological changes caused by Different types of etiopathogenises, is also commonly encountered diseases, frequently-occurring disease clinically.Current doctor trained in Western medicine is to CG, especially chronic atrophic gastritis still lacks effective treatment means, and the developmental pattern of chronic superficial gastritis-chronic atrophic gastritis-intestinal epithelial metaplasia, atypical hyperplasia-gastric cancer generally acknowledge by domestic and international expert, cure CG to preventing and treating being significant of gastric cancer.But primary disease still lacks the Western medicine of determined curative effect, few side effects at present, and treatment by Chinese herbs has the advantage of its uniqueness.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of chronic gastritis.
In order to realize object of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of chronic gastritis, it is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 30-50 part, Radix Schisandrae Bicoloris 30-80 part, Caulis Parameriae Laevigatae 40-50 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40-50 part, szechwan raspberry 40-60 part, Radix Ligustici Brachylobi 30-50 part, Radix Morindae Officinalis 40-50 part, Herba Tagetis Patulae 30-50 part, Herba Ceratopteridis Thalictroidis 30-50 part, Herba Inulae cappae 40-60 part, Herba Aletridis Khasianae 30-40 part, Flos Hibisci Rosae-Sinensis 40-50 part, Herba Ixeritis Denticulatae 30-50 part, Fructus Elaeagni 30-50 part, Cortex betulae platyphyllae 20-50 part, lip Rhizoma et radix valerianae 20-50 part, Lombardy poplar 30-50 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 20-50 part and Radix Glycyrrhizae 30-40 part.
Preferably, the pharmaceutical composition of described treatment chronic gastritis is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 35 parts, Radix Schisandrae Bicoloris 50 parts, Caulis Parameriae Laevigatae 45 parts, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 45 parts, szechwan raspberry 50 parts, Radix Ligustici Brachylobi 35 parts, Radix Morindae Officinalis 45 parts, Herba Tagetis Patulae 35 parts, Herba Ceratopteridis Thalictroidis 40 parts, Herba Inulae cappae 50 parts, Herba Aletridis Khasianae 35 parts, Flos Hibisci Rosae-Sinensis 45 parts, Herba Ixeritis Denticulatae 40 parts, Fructus Elaeagni 35 parts, Cortex betulae platyphyllae 30 parts, lip Rhizoma et radix valerianae 30 parts, Lombardy poplar 35 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 30 parts and 35 parts, Radix Glycyrrhizae.
More preferably, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or decoction.
The present invention also provides the purposes of compositions in the medicine of preparation treatment chronic gastritis, described compositions is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 30-50 part, Radix Schisandrae Bicoloris 30-80 part, Caulis Parameriae Laevigatae 40-50 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40-50 part, szechwan raspberry 40-60 part, Radix Ligustici Brachylobi 30-50 part, Radix Morindae Officinalis 40-50 part, Herba Tagetis Patulae 30-50 part, Herba Ceratopteridis Thalictroidis 30-50 part, Herba Inulae cappae 40-60 part, Herba Aletridis Khasianae 30-40 part, Flos Hibisci Rosae-Sinensis 40-50 part, Herba Ixeritis Denticulatae 30-50 part, Fructus Elaeagni 30-50 part, Cortex betulae platyphyllae 20-50 part, lip Rhizoma et radix valerianae 20-50 part, Lombardy poplar 30-50 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 20-50 part and Radix Glycyrrhizae 30-40 part.
Preferably, described compositions is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 35 parts, Radix Schisandrae Bicoloris 50 parts, Caulis Parameriae Laevigatae 45 parts, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 45 parts, szechwan raspberry 50 parts, Radix Ligustici Brachylobi 35 parts, Radix Morindae Officinalis 45 parts, Herba Tagetis Patulae 35 parts, Herba Ceratopteridis Thalictroidis 40 parts, Herba Inulae cappae 50 parts, Herba Aletridis Khasianae 35 parts, Flos Hibisci Rosae-Sinensis 45 parts, Herba Ixeritis Denticulatae 40 parts, Fructus Elaeagni 35 parts, Cortex betulae platyphyllae 30 parts, lip Rhizoma et radix valerianae 30 parts, Lombardy poplar 35 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 30 parts and 35 parts, Radix Glycyrrhizae.
More preferably, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or decoction.
In the present invention, Herba Ludwigiae Prostratae, Radix Schisandrae Bicoloris, Caulis Parameriae Laevigatae are monarch drug; Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani), Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), szechwan raspberry, Radix Ligustici Brachylobi, Radix Morindae Officinalis, Herba Tagetis Patulae are ministerial drug; Herba Ceratopteridis Thalictroidis, Herba Inulae cappae, Herba Aletridis Khasianae, Flos Hibisci Rosae-Sinensis, Herba Ixeritis Denticulatae, Fructus Elaeagni, Cortex betulae platyphyllae, lip Rhizoma et radix valerianae, Lombardy poplar, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, plays the effect making medicine in the compositions of the present invention.
All medicines are harmonious in the present invention, reasonable recipe, giving consideration to both the incidental and fundamental, and adjust, regulating qi and dredging collateral with QI and blood, regulating QI is with promoting the circulation of blood, dredging collateral is with promoting the circulation of QI, and not bitterly, therapeutic effect is remarkable for general rule.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment decoction of the present invention
Take Herba Ludwigiae Prostratae 35 grams, Radix Schisandrae Bicoloris 50 grams, Caulis Parameriae Laevigatae 45 grams, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 grams, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 45 grams, szechwan raspberry 50 grams, Radix Ligustici Brachylobi 35 grams, Radix Morindae Officinalis 45 grams, Herba Tagetis Patulae 35 grams, Herba Ceratopteridis Thalictroidis 40 grams, Herba Inulae cappae 50 grams, Herba Aletridis Khasianae 35 grams, Flos Hibisci Rosae-Sinensis 45 grams, Herba Ixeritis Denticulatae 40 grams, Fructus Elaeagni 35 grams, Cortex betulae platyphyllae 30 grams, lip Rhizoma et radix valerianae 30 grams, Lombardy poplar 35 grams, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 30 grams and 35 grams, Radix Glycyrrhizae; add 9000 milliliters, water; heating 3 hours under the condition of backflow; filter; make filtrate be cooled to room temperature, to obtain final product.
Toxicity test
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 30, i.e. matched group and administration group, fasting 12 hours before experiment; The decoction prepared in adjustment embodiment, concentration is made to be 6.48g crude drug/ml, gavage, gavage volume is 5ml/kg (namely unit dosage form is 32.4g crude drug/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Select to put to death administration group mice, test under microscope: the important organs such as the heart, liver, lung, gastric and thymus, no abnormality seen changes.Mouse oral gavage decoction LD of the present invention
50>32.4g crude drug/kg, every day, maximum dosage-feeding was 64.8g crude drug/kg/ day.Clinical drug dosage of the present invention be 6.85g crude drug/day/people, adult body weight in 60kg, average dosage is 0.114g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 568 times of quantity.Therefore the decoction acute toxicity that takes orally of the present invention is low, clinical drug safety.
Long term toxicity test: application SD rat, body weight 200g ± 10g, male and female half and half.The decoction prepared in embodiment is used to test.Prepare high, medium and low three dosage groups, be respectively 300,150,75 times of clinical application amount, mix with the normal saline 1:1 containing 2 % by weight Radix Acaciae senegalis.Adopt gastric infusion mode, continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and each internal organs of rat are all without obviously changing.Illustrate that the decoction that the present invention is taken orally is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Experimental example
Choose patient 60 example, wherein man 41 example, female 19 example, age 23-55 year, average 36 years old, the shortest person of the course of disease 1 week, most elder reached 1 year.All patients underwent's electronic gastroscopes, C14 breath test and histopathological examination, meet diagnostic criteria (Chinese Medical Association disease for digest credit meeting Chinese National Consensus on Chronic Gastritis [J] gastroenterology of " Chinese National Consensus on Chronic Gastritis ", 2006,11 (11), 674-684), wherein chronic non-atrophic gastritis 48 example (superficial gastritis 17 example, erosive gastritis 20 example, hemorrhagic gastritis 11 example), unrestrained property atrophic gastritis 12 example.C14 breath test is helicobacter pylori (HP) positive 55 example.All get rid of and merge the complete and not pregnant case of peptic ulcer, tumor, liver Biliary tract, cardiorenal function; Get rid of in nearly 2 weeks simultaneously and used antibiotic, bismuth, proton pump inhibitor and to drug allergy person used.Glutted discomfort after upper abdomen and breastbone in clinical manifestation, distending pain, dull pain and burn feeling, some patients with pantothenic acid belch, dry throat with bitter taste, feel sick, regurgitation, vomiting.Middle epigastrium of having a medical check-up can have the dark tenderness of the light moderate of limitation and pressing discomfort.
Decoction prepared by oral embodiment is treated, every day 2 times, clinical drug dosage be 6.85g crude drug/day/people, within 15 days, be a course for the treatment of.
Efficacy determination
With reference to (Zhang Wandai, Chen Zhishui, the danger North Sea. combination of Chinese and Western medicine diagnosis and treatment project (draft) [J] Chinese combination of Chinese and Western medicine magazine of chronic gastritis, 2005,25 (2): 173) evaluate curative effect.1. cure: clinical symptoms and sign disappear, gastroscope check gastric mucosa Active inflammation disappears, and HP turns out cloudy, and chronic inflammatory disease is pass on well slightly.2. effective: clinical basic disappearance, gastroscope check gastric mucosa Active inflammation disappears substantially, and HP turns out cloudy, and chronic inflammatory disease takes a turn for the better.3. effective: symptom obviously alleviates, gastroscope check mucosa infection range shorter more than 1/2, HP is positive in turning by force weak or turning out cloudy, and inflammation alleviates to some extent.4. invalid: symptom and gastroscope check are without changing, and even increase the weight of, HP is still positive.
Therapeutic outcome
Through treatment, find to cure 43 examples in 60 routine patients, effective 12 examples, effective 5 examples, total effective rate is 100%.And do not find obvious untoward reaction over the course for the treatment of.
Claims (6)
1. treat the pharmaceutical composition of chronic gastritis for one kind, it is characterized in that, it is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 30-50 part, Radix Schisandrae Bicoloris 30-80 part, Caulis Parameriae Laevigatae 40-50 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40-50 part, szechwan raspberry 40-60 part, Radix Ligustici Brachylobi 30-50 part, Radix Morindae Officinalis 40-50 part, Herba Tagetis Patulae 30-50 part, Herba Ceratopteridis Thalictroidis 30-50 part, Herba Inulae cappae 40-60 part, Herba Aletridis Khasianae 30-40 part, Flos Hibisci Rosae-Sinensis 40-50 part, Herba Ixeritis Denticulatae 30-50 part, Fructus Elaeagni 30-50 part, Cortex betulae platyphyllae 20-50 part, lip Rhizoma et radix valerianae 20-50 part, Lombardy poplar 30-50 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 20-50 part and Radix Glycyrrhizae 30-40 part.
2. the pharmaceutical composition for the treatment of chronic gastritis according to claim 1; it is characterized in that, it is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 35 parts, Radix Schisandrae Bicoloris 50 parts, Caulis Parameriae Laevigatae 45 parts, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 45 parts, szechwan raspberry 50 parts, Radix Ligustici Brachylobi 35 parts, Radix Morindae Officinalis 45 parts, Herba Tagetis Patulae 35 parts, Herba Ceratopteridis Thalictroidis 40 parts, Herba Inulae cappae 50 parts, Herba Aletridis Khasianae 35 parts, Flos Hibisci Rosae-Sinensis 45 parts, Herba Ixeritis Denticulatae 40 parts, Fructus Elaeagni 35 parts, Cortex betulae platyphyllae 30 parts, lip Rhizoma et radix valerianae 30 parts, Lombardy poplar 35 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 30 parts and 35 parts, Radix Glycyrrhizae.
3. the pharmaceutical composition for the treatment of chronic gastritis according to claim 2, is characterized in that, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or decoction.
4. the purposes of compositions in the medicine of preparation treatment chronic gastritis, it is characterized in that, described compositions is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 30-50 part, Radix Schisandrae Bicoloris 30-80 part, Caulis Parameriae Laevigatae 40-50 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 30-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40-50 part, szechwan raspberry 40-60 part, Radix Ligustici Brachylobi 30-50 part, Radix Morindae Officinalis 40-50 part, Herba Tagetis Patulae 30-50 part, Herba Ceratopteridis Thalictroidis 30-50 part, Herba Inulae cappae 40-60 part, Herba Aletridis Khasianae 30-40 part, Flos Hibisci Rosae-Sinensis 40-50 part, Herba Ixeritis Denticulatae 30-50 part, Fructus Elaeagni 30-50 part, Cortex betulae platyphyllae 20-50 part, lip Rhizoma et radix valerianae 20-50 part, Lombardy poplar 30-50 part, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 20-50 part and Radix Glycyrrhizae 30-40 part.
5. purposes according to claim 4; it is characterized in that, described compositions is made up by weight of following bulk drugs: Herba Ludwigiae Prostratae 35 parts, Radix Schisandrae Bicoloris 50 parts, Caulis Parameriae Laevigatae 45 parts, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 40 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 45 parts, szechwan raspberry 50 parts, Radix Ligustici Brachylobi 35 parts, Radix Morindae Officinalis 45 parts, Herba Tagetis Patulae 35 parts, Herba Ceratopteridis Thalictroidis 40 parts, Herba Inulae cappae 50 parts, Herba Aletridis Khasianae 35 parts, Flos Hibisci Rosae-Sinensis 45 parts, Herba Ixeritis Denticulatae 40 parts, Fructus Elaeagni 35 parts, Cortex betulae platyphyllae 30 parts, lip Rhizoma et radix valerianae 30 parts, Lombardy poplar 35 parts, Abacopteris multilineata(Wall.) Ching (Pronephrium multilineatum (Wall.) ching 30 parts and 35 parts, Radix Glycyrrhizae.
6. purposes according to claim 5, is characterized in that, described medicine can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, patch or decoction.
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| CN201510080023.2A CN104587142A (en) | 2015-02-13 | 2015-02-13 | Medicine composition for treating chronic gastritis |
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| CN201510080023.2A CN104587142A (en) | 2015-02-13 | 2015-02-13 | Medicine composition for treating chronic gastritis |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009008803A1 (en) * | 2007-07-11 | 2009-01-15 | Food & Health Concept Centre I Väst Ab | Inhibition of gastroduodenal diseases in humans by common edible plants |
| CN102488801A (en) * | 2011-12-12 | 2012-06-13 | 王翠云 | Medicine composition for curing chronic gastritis |
| CN103041308A (en) * | 2012-12-18 | 2013-04-17 | 青州市经济开发区卫生院 | Drug for curing chronic gastritis |
-
2015
- 2015-02-13 CN CN201510080023.2A patent/CN104587142A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009008803A1 (en) * | 2007-07-11 | 2009-01-15 | Food & Health Concept Centre I Väst Ab | Inhibition of gastroduodenal diseases in humans by common edible plants |
| CN102488801A (en) * | 2011-12-12 | 2012-06-13 | 王翠云 | Medicine composition for curing chronic gastritis |
| CN103041308A (en) * | 2012-12-18 | 2013-04-17 | 青州市经济开发区卫生院 | Drug for curing chronic gastritis |
Non-Patent Citations (2)
| Title |
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| 张前德等: "《慢性病：中医临床特色与优势》", 31 July 2013, 江苏科学技术出版社 * |
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