CN104257800B - A kind of medicament of Acne treatment - Google Patents

A kind of medicament of Acne treatment Download PDF

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CN104257800B
CN104257800B CN201410563407.5A CN201410563407A CN104257800B CN 104257800 B CN104257800 B CN 104257800B CN 201410563407 A CN201410563407 A CN 201410563407A CN 104257800 B CN104257800 B CN 104257800B
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grams
parts
medicament
present
acne treatment
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CN104257800A (en
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朱宁生
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/79—Schisandraceae (Schisandra family)
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Abstract

The present invention relates to a kind of medicament of Acne treatment, it comprises following material: snake slough, peach blossom, leech, Radix Glycyrrhizae etc. Medicament of the present invention interacts, synergy, and Acne treatment effect is remarkable, and clinic is promoted.

Description

A kind of medicament of Acne treatment
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament of Acne treatment.
Background technology
Acne is a kind of pilosebaceous follicle chronic inflammation dermatoses, mainly due to androgen secretion increasing in puberty, and thornSwash target organ sebaceous glands, make sebum secretion vigorous, sebaceous glands increases, pilosebaceous duct hyperkeratinization, and sebum deposits at hairCapsule forms keratotic plug, and follicular orifice stops up, and propionibacterium acnes amount reproduction causes local inflammation to produce. Its occur also with heredity andPsychological factor is relevant. Western medical treatment acne mainly contains and kills propionibacterium acnes, suppresses the methods such as smegma, though have at presentCertain curative effect, but there is resistance and toxic and side effect, patient is difficult for accepting.
Summary of the invention
The object of this invention is to provide a kind of medicament of Acne treatment.
In order to realize object of the present invention, the invention provides a kind of medicament of Acne treatment, it comprises following weight portionMaterial: snake slough 10-30 part, peach blossom 30-70 part, leech 10-50 part and Radix Glycyrrhizae 20-60 part.
Preferably, the pharmacy kit of Acne treatment of the present invention contains the material of following weight portion: 25 parts of snake sloughs, peach blossom 50Part, 40 parts, 35 parts of leech and Radix Glycyrrhizae.
More preferably, the medicament of Acne treatment of the present invention also comprises the material of following weight portion: luffa 20-50Part, Flos Albiziae 30-80 part, frangipanis 10-50 part, Chinese yam 30-70 part, lotus seeds 10-50 part, loranthus kaempferi 10-30 part, Folium Apocyni Veneti20-50 part, Herba Wedeliae biflorae 10-30 part, kadsura longepedunculata 30-50 part, pass through muscle rattan 10-30 part, the 20-50 part that plays both sides of the street, red bayberry 30-50Part, common tripterospermum herb 10-30 part, seed of cowherb 40-70 part, gynostemma pentaphylla 30-60 part, willowweed 20-50 part, wilsonii 30-70 part, lipVanilla 10-50 part, fruit of Rangoon creeper's leaf 30-80 part, salsola collina 20-60 part, bighead atractylodes rhizome 20-80 part and the root of straight ladybell 10-50 part.
Most preferably, the medicament of Acne treatment of the present invention also comprises the material of following weight portion: 30 parts of luffas,60 parts of Flos Albiziaes, 30 parts of frangipanis, 50 parts of Chinese yams, 35 parts, lotus seeds, 15 parts of loranthus kaempferis, 30 parts of Folium Apocyni Venetves, 15 parts of Herba Wedeliae bifloraes, south40 parts, the fruit of Chinese magnoliavine, pass through 25 parts, muscle rattan, play both sides of the street 30 parts, 45 parts, red bayberry, 25 parts of common tripterospermum herbs, 55 parts of the seeds of cowherb, 45 parts of gynostemma pentaphylla,35 parts of 30 parts of willowweeds, 50 parts of wilsoniis, 30 parts of lip vanillas, 60 parts, fruit of Rangoon creeper's leaf, 45 parts of salsola collinas, 45 parts of the bighead atractylodes rhizomes and the root of straight ladybell.
Preferably, described medicament can be tablet, dispersing tablet, capsule, soft capsule or decoction.
The present invention also provides the purposes of medicament in the medicine of preparing Acne treatment, and described pharmacy kit is containing following weight portionMaterial: snake slough 10-30 part, peach blossom 30-70 part, leech 10-50 part and Radix Glycyrrhizae 20-60 part.
Preferably, described pharmacy kit contains the material of following weight portion: 25 parts of snake sloughs, 50 parts, peach blossom, 35 parts of leech and Radix Glycyrrhizae40 parts.
More preferably, described medicament also comprises the material of following weight portion: luffa 20-50 part, Flos Albiziae 30-80 part,Frangipanis 10-50 part, Chinese yam 30-70 part, lotus seeds 10-50 part, loranthus kaempferi 10-30 part, Folium Apocyni Veneti 20-50 part, Herba Wedeliae biflorae 10-30 parts, kadsura longepedunculata 30-50 part, pass through muscle rattan 10-30 part, the 20-50 part that plays both sides of the street, red bayberry 30-50 part, common tripterospermum herb 10-30 part, kingDo not stay row 40-70 part, gynostemma pentaphylla 30-60 part, willowweed 20-50 part, wilsonii 30-70 part, lip vanilla 10-50 part, the fruit of Rangoon creeperLeaf 30-80 part, salsola collina 20-60 part, bighead atractylodes rhizome 20-80 part and the root of straight ladybell 10-50 part.
Most preferably, described medicament also comprises the material of following weight portion: 30 parts of luffas, 60 parts of Flos Albiziaes, frangipanis30 parts, 50 parts of Chinese yams, 35 parts, lotus seeds, 15 parts of loranthus kaempferis, 30 parts of Folium Apocyni Venetves, 15 parts of Herba Wedeliae bifloraes, 40 parts of kadsura longepedunculatas, pass through muscle rattan25 parts, 30 parts, 45 parts, red bayberry, 25 parts of common tripterospermum herbs, 55 parts of the seeds of cowherb, 45 parts of gynostemma pentaphylla, 30 parts of willowweeds, wilsonii play both sides of the street35 parts of 50 parts, 30 parts of lip vanillas, 60 parts, fruit of Rangoon creeper's leaf, 45 parts of salsola collinas, 45 parts of the bighead atractylodes rhizomes and the root of straight ladybell.
Preferably, described medicament can be tablet, dispersing tablet, capsule, soft capsule or decoction.
Generally acknowledge that at present " organic conception ", " diagnosis and treatment based on an overall analysis of the illness and the patient's condition ", " compound use ", " compound compatibility medication is as used military forces " are the traditional Chinese medical scienceMost scientific the most several large advantages, wherein " compound compatibility medication is as used military forces " is the original theory of traditional Chinese medicine of very science. InEach medicine tight compatibility all linked with one another as arrayed troops for battle in doctor's prescription is that it is better than effective means that Western medicine is filled a prescription. The traditional Chinese medical sciencePrescription theory is thought, each prescription not only needs to select the appropriate compatibility of suitable medicament according to etiology and pathogenesis, also should accord with simultaneouslyClose the basic structure of prescription, i.e. the prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make ", justThat it is based upon the scientific matching on the comprehensive judgement basis of the disease interpretation of the cause, onset and process of an illness. In medical square tube cross too many levels, many target spots are wholeClose the biological mechanism of adjusting, can obtain than Western medicine more lastingly, result for the treatment of that more green natural has no side effect, and thisCurative effect is to be based upon on the accurate instruction of the original theory of above-mentioned traditional Chinese medical science tradition, and the present invention is just following this principle.
In composition of the present invention, Herba Wedeliae biflorae is monarch drug in a prescription with passing through muscle rattan; Snake slough, peach blossom, leech, luffa, Flos Albiziae,Frangipanis, Chinese yam, lotus seeds, loranthus kaempferi, Folium Apocyni Veneti, kadsura longepedunculata, play both sides of the street, red bayberry is ministerial drug; Common tripterospermum herb, the seed of cowherb,Gynostemma pentaphylla, willowweed, wilsonii, lip vanilla, fruit of Rangoon creeper's leaf, salsola collina, the bighead atractylodes rhizome, the root of straight ladybell are adjutant; Radix Glycyrrhizae coordinating the drug actions of a prescription, for makingMedicine. Pharmaceutical composition of the present invention interacts, and synergy, complements each other, and plays altogether the merit of monarch, Acne treatmentEffect is remarkable, and clinic is promoted.
Detailed description of the invention
Further illustrate the present invention below by embodiment. It should be understood that embodiments of the invention are for explanationThe present invention instead of limitation of the present invention. The simple modifications that essence according to the present invention is carried out the present invention all belongs to the present inventionClaimed scope. Except as otherwise noted, the percentage otherwise in the present invention is percetage by weight.
Embodiment decoction of the present invention
Take 25 grams of snake sloughs, 50 grams, peach blossom, 35 grams of leech, 40 grams, Radix Glycyrrhizae, 30 grams of luffas, 60 grams of Flos Albiziaes, frangipanis30 grams, 50 grams of Chinese yams, 35 grams, lotus seeds, 15 grams of loranthus kaempferis, 30 grams of Folium Apocyni Venetves, 15 grams of Herba Wedeliae bifloraes, 40 grams of kadsura longepedunculatas, pass through muscle rattan25 grams, 30 grams, 45 grams, red bayberry, 25 grams of common tripterospermum herbs, 55 grams of the seeds of cowherb, 45 grams of gynostemma pentaphylla, 30 grams of willowweeds, wilsonii play both sides of the street35 grams of 50 grams, 30 grams of lip vanillas, 60 grams, fruit of Rangoon creeper's leaf, 45 grams of salsola collinas, 45 grams of the bighead atractylodes rhizomes and the root of straight ladybell, add 8000 ml waters,Be equipped with in the flask of condenser pipe and add hot reflux 5 hours, then filter, make filtrate be cooled to room temperature, to obtain final product.
Toxicity test
Acute toxicity test: 60 of application NIH mouse, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicityTest. Mouse is divided into two groups at random, and 30 every group, i.e. control group and administration group, fasting 12 hours before experiment; Adjust in embodimentThe decoction of preparation, making concentration is 4.51g crude drug/ml, gavage, gavage volume is that 5ml/kg (is that single-dose dosage is22.55g crude drug/kg), control group gives equivalent physiological saline, administration in a day 2 times, delivery time 6 hours, connects after administrationContinuous observation 14 days, and record toxic reaction and the death toll of mouse. Experimental result shows: with control group comparison, and mouse after administrationHave no notable difference, experiment Continuous Observation 14 days, mouse overall health of patients, diet, drinking-water, body weight gain are all normal. Select to put to deathAdministration group mouse, test under microscope: in the heart, liver, lung, stomach and the important organ such as thymus gland, no abnormality seen changes. The oral filling of mouseStomach decoction LD of the present invention50> 22.55g crude drug/kg, every day, maximum dosage-feeding was 45.1g crude drug/kg/ day. Medicine of the present inventionClinical application amount is 6.39g crude drug/day/people, becomes body weight for humans in 60kg, and average dosage is 0.1065g crude drug/kg/ day.By batheroom scale: the dosis tolerata of mouse (average weight is taking 21g) oral administration gavage Chinese medicine of the present invention is 423 times of quantity.Therefore the present invention's pharmaceutical composition acute toxicity for oral administration is low, clinical drug safety.
Long term toxicity test: application SD rat, body weight 200g ± 10g, male and female half and half. Use the decoction of preparing in embodimentTest. Prepare high, medium and low three dosage groups, be respectively 300,150,75 times of clinical application amount, with containing 2 % by weightThe physiological saline 1:1 of gum arabic mixes. Adopt gastric infusion mode, 16 weeks (1.0ml/100g body weight, every days of continuous use2 times) and drug withdrawal after 4 weeks, result shows: hair, behavior, stool and urine, body weight, organ weights, the blood of medicine of the present invention to ratResemble, the index such as hepatic and renal function, blood sugar, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examinationResult shows, medication 16 weeks and drug withdrawal are after 4 weeks, and the each internal organs of rat are all without obviously changing. The drug regimen that the present invention is for oral administration is describedThing to rat long-term prescription after toxicity little, after drug withdrawal, there is no difference reaction, application safety yet.
Experimental example
Physical data
In October, 2012-2014 patients with acne 60 examples that year March, hospital accepted for medical treatment, the wherein male sex's 30 examples, women's 30 examples; Age21-36 year, year mean age (25 ± 3.2), average course of disease (2 ± 1.3) year, by weight classification, I degree 25 examples, II degree 21 examples,III degree 10 examples, IV degree 4 examples.
Diagnostic criteria
Acne diagnostic criteria: according to " clinical Dermatology " (Zhao distinguishes. clinical Dermatology .3 version [M]. Nanjing: Jiangsu sectionSkill publishing house, 2002:935.) formulation of acne vulgaris diagnostic criteria. 1. youth of both sexes; 2. in face and and shirtfront back have blackheadAcne, papule, useless fellow and tubercle; 3. symmetrical.
Acne weight grade scale (according to " new Chinese medicine guideline of clinical investigations ") is formulated: I degree: blackhead is looseSend to multiplely, struvite fash is distributed; II degree: I degree+shallow in property fester inflammation, fash number increases, and is limited to and portion; III degree:II degree+deeply in property fash, occur in and, neck, chest, back; IV degree: III degree+tumour, easily form paralysed trace, occur in above the waist.
Treat with the decoction of preparing in embodiment, every day 2 times, clinical drug dosage of the present invention is6.39g crude drug/day/people. Treatment 20 days continuously.
The standard of curative effect evaluation
Criterion of therapeutical effect reference " new Chinese medicine guideline of clinical investigations " (Ministry of Health of the People's Republic of China. new Chinese medicineThe 3rd volume of [S] .1997:89. of guideline of clinical investigations) work out. Recovery from illness: skin damage disappear >=95%, only leave pigmentation,Occur without new fash; Effective: skin damage disappear>=70% and<95%, newly play fash and be less than 5; Effective: skin damage disappear>=50% and< 70%, newly play fash and be less than 10; Invalid: skin damages to disappear and is less than 50% or even add severe one without significant change.
Result
Through treatment, 46 examples of fully recovering in 60 routine patients, effective 10 examples, effective 4 examples, total effective rate 100%.

Claims (1)

1. a medicament for Acne treatment, is characterized in that, it is made by following method: take 25 grams of snake sloughs, 50 grams, peach blossom,35 grams of leech, 40 grams, Radix Glycyrrhizae, 30 grams of luffas, 60 grams of Flos Albiziaes, 30 grams of frangipanis, 50 grams of Chinese yams, 35 grams, lotus seeds, loranthus kaempferi 15Gram, 30 grams of Folium Apocyni Venetves, 15 grams of Herba Wedeliae bifloraes, 40 grams of kadsura longepedunculatas, pass through 25 grams, muscle rattan, 30 grams, 45 grams, red bayberry, common tripterospermum herb play both sides of the street25 grams, 55 grams of the seeds of cowherb, 45 grams of gynostemma pentaphylla, 30 grams of willowweeds, 50 grams of wilsoniis, 30 grams of lip vanillas, 60 grams, fruit of Rangoon creeper's leaf, pig35 grams of hair 45 grams of dishes, 45 grams of the bighead atractylodes rhizomes and the root of straight ladybell, add 8000 ml waters, adds hot reflux 5 hours in the flask that condenser pipe is housed,Then filter, make filtrate be cooled to room temperature, to obtain final product.
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