CN109200248A - A kind of Chinese medicine composition for treating lymthoma - Google Patents
A kind of Chinese medicine composition for treating lymthoma Download PDFInfo
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- CN109200248A CN109200248A CN201811381441.5A CN201811381441A CN109200248A CN 109200248 A CN109200248 A CN 109200248A CN 201811381441 A CN201811381441 A CN 201811381441A CN 109200248 A CN109200248 A CN 109200248A
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Abstract
The present invention relates to a kind of Chinese medicine compositions for treating lymthoma, Chinese medicine material medicine according to parts by weight are as follows: 20-30 parts of trigone, 15-30 parts of curcuma zedoary, 20-60 parts of Radix Astragali, 25-50 parts of radix scrophulariae, 10-20 parts of kuh-seng, 20-50 parts of Prunella vulgaris, 15-30 parts of Radix Angelicae Sinensis, 30 parts -60 parts of Radix Salviae Miltiorrhizae, 20-30 parts of Rhizoma Chuanxiong, 20-60 parts of oldenlandia diffusa, 10-30 parts of Radix Glycyrrhizae, 20-35 parts of Sculellaria barbata, 10-30 parts of the tuber of pinellia, 15-30 parts of radix scutellariae, 15-30 parts of Fructus Forsythiae, 15-30 parts of safflower, 35 parts -60 parts of Radix Codonopsis, 20-30 parts of Rhizoma Atractylodis Macrocephalae, 20-30 parts of radix bupleuri, 15-30 parts of Radix Isatidis, 10-30 parts of fritillaria thunbergii, 15-30 parts of radix ranunculi ternati, 10-35 parts of Poria cocos, nidus vespae 20-3 0 part, 15-60 parts of the fruit of glossy privet, 20-30 parts of Radix Paeoniae Alba.By using above-mentioned technical proposal, the effect of clearing heat and detoxicating, mass dissipating and swelling eliminating, eliminating dampness and eliminating phlegm, invigorating the spleen qi-regulating, activating microcirculation and removing stasis medicinal, promoting qi circulation and relieving pain, to inhibit or kill cancer cell, cancer is eliminated to make, immunity of organisms is improved, Malignant tumor of bonal metastasis and recurrence are prevented, can be clinically used for treatment lymthoma.
Description
Technical field
The present invention relates to Chinese medicine composition, in particular to a kind of Chinese medicine composition for treating lymthoma.
Background technique
Lymthoma is initiated by the malignant tumour of lymphohematological, is mainly shown as Silent Neuritis enlargement of lymph nodes, liver and spleen
Enlargement, each histoorgan of whole body can be involved, and occur together the constitutional symptoms such as heat, night sweat, syntexis, itch.It is divided into according to oncocyte non-
Two class of Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL).The cause of disease is unclear.It is generally believed that may and gene mutation, and
It is related to merge autoimmunity disease etc. for virus and other pathogenic infections, radioactive ray, chemicals.
Currently used treatment method has radiotherapy, chemotherapy, operative treatment, interventional therapy etc..Due to lymthoma
90% or more belongs to middle and advanced stage when making a definite diagnosis, and operative chance has been missed more, so integrated approach is mostly used to be treated.But radiation is controlled
Treatment, chemotherapy toxic side effect are big, while killing cancer cell, also kill many normal healthy cells of human body, cause
Patient new chemotherapy and radiation disease, make patient's heart, liver,spleen,kidney and digestive system by different degrees of damage, cause machine
Body immunity function decline, the normal hypofunction of parts of body, the control and treatment that the state of an illness cannot be often satisfied with；Intervention is treated
Though method has certain curative effect, cost is larger, and many patients do not afford to do.
Currently, there are many drug for the treatment of malignant lymphoma, but less effective, it is at all right that basic reason is to catch
Disease treatment, therefrom medically says, studies carefully its Crack cause for treating malignant lymphoma, not outer body ressitance weakened while pathogenic factors prevailing, weakened body resistance then anti-evil machine grade
Lowly, thus there are a series of pathological changes such as the stagnation of the circulation of vital energy, blood stasis, food wound, wet poly-, cult poison aggregation, in various external pathogenic factors
Long term is in human body, and body cannot eliminate the influence of these pathogenic factors and qi depression to blood stasis, heresy occurs at lymph position
Poison pents up, zang-fu disharmony, forms susceptible body；The domination of pathogen then includes that malicious Shengs, phlegm knot, blood stasis gather into tangible knot, therefore, is sent out
Bright a kind of couple of human injury is small, the Chinese medicine composition of the good complex treatment lymthoma of effect, is the hot spot of current Chinese medicine medicine research.
Summary of the invention
In conclusion in order to overcome the deficiencies of the prior art, the present invention provides a kind of Chinese medicine composition for treating lymthoma, it should
The problem of Chinese medicine composition can effectively solve the control and treatment of malignant lymphoma, build up health, and extend patient vitals.
To achieve the above object, the present invention provides the following technical scheme that a kind of Chinese medicine composition for treating lymthoma, is pressed
Parts by weight meter Chinese medicine material medicine are as follows: 20-30 parts of trigone, 15-30 parts of curcuma zedoary, 20-60 parts of Radix Astragali, 25-50 parts of radix scrophulariae, kuh-seng
10-20 parts, 20-50 parts of Prunella vulgaris, 15-30 parts of Radix Angelicae Sinensis, 30 parts -60 parts of Radix Salviae Miltiorrhizae, 20-30 parts of Rhizoma Chuanxiong, oldenlandia diffusa 20-60
Part, 10-30 parts of Radix Glycyrrhizae, 20-35 parts of Sculellaria barbata, 10-30 parts of the tuber of pinellia, 15-30 parts of radix scutellariae, 15-30 parts of Fructus Forsythiae, 15-30 parts of safflower,
35 parts -60 parts of Radix Codonopsis, 20-30 parts of Rhizoma Atractylodis Macrocephalae, 20-30 parts of radix bupleuri, 15-30 parts of Radix Isatidis, 10-30 parts of fritillaria thunbergii, radix ranunculi ternati 15-30
Part, 10-35 parts of Poria cocos, 20-30 parts of nidus vespae, 15-60 parts of the fruit of glossy privet, 20-30 parts of Radix Paeoniae Alba.
Preferred Chinese medicine material medicine according to parts by weight are as follows: 20 parts of trigone, 15 parts of curcuma zedoary, 30 parts of Radix Astragali, 35 parts of radix scrophulariae, hardship
Join 10 parts, 20 parts of Prunella vulgaris, 15 parts of Radix Angelicae Sinensis, 35 parts of Radix Salviae Miltiorrhizae, 25 parts of Rhizoma Chuanxiong, 20 parts of oldenlandia diffusa, 10 parts of Radix Glycyrrhizae, Sculellaria barbata 20
Part, 10 parts of the tuber of pinellia, 20 parts of radix scutellariae, 20 parts of Fructus Forsythiae, 15 parts of safflower, 35 parts of Radix Codonopsis, 20 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of radix bupleuri, 15 parts of Radix Isatidis,
15 parts of fritillaria thunbergii, 15 parts of radix ranunculi ternati, 10 parts of Poria cocos, 20 parts of nidus vespae, 25 parts of the fruit of glossy privet, 25 parts of Radix Paeoniae Alba.
Preferred Chinese medicine material medicine according to parts by weight are as follows: 15 parts of trigone, 30 parts of curcuma zedoary, 20 parts of Radix Astragali, 25 parts of radix scrophulariae, hardship
Join 15 parts, 30 parts of Prunella vulgaris, 20 parts of Radix Angelicae Sinensis, 30 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 60 parts of oldenlandia diffusa, 30 parts of Radix Glycyrrhizae, Sculellaria barbata 30
Part, 20 parts of the tuber of pinellia, 15 parts of radix scutellariae, 15 parts of Fructus Forsythiae, 20 parts of safflower, Radix Codonopsis 45,25 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of radix bupleuri, 30 parts of Radix Isatidis, Zhejiang
10 parts of fritillaria, 25 parts of radix ranunculi ternati, 35 parts of Poria cocos, 25 parts of nidus vespae, 60 parts of the fruit of glossy privet, 20 parts of Radix Paeoniae Alba.
Preferred Chinese medicine material medicine according to parts by weight are as follows: 30 parts of trigone, 25 parts of curcuma zedoary, 60 parts of Radix Astragali, 50 parts of radix scrophulariae, hardship
Join 20 parts, 50 parts of Prunella vulgaris, 30 parts of Radix Angelicae Sinensis, 60 parts of Radix Salviae Miltiorrhizae, 30 parts of Rhizoma Chuanxiong, 30 parts of oldenlandia diffusa, 20 parts of Radix Glycyrrhizae, Sculellaria barbata 35
Part, 15 parts of the tuber of pinellia, 30 parts of radix scutellariae, 30 parts of Fructus Forsythiae, 30 parts of safflower, 60 parts of Radix Codonopsis, 30 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of radix bupleuri, 25 parts of Radix Isatidis,
30 parts of fritillaria thunbergii, 30 parts of radix ranunculi ternati, 15 parts of Poria cocos, 30 parts of nidus vespae, 15 parts of the fruit of glossy privet, 30 parts of Radix Paeoniae Alba.
The Chinese medicine composition preparation method, is specifically implemented according to the following steps: the starting material with water is decocted twice, every time
1 to 2 hours, the water measured for the first time with 6 to 10 times, second of the water measured with 4 to 8 times, wherein the amount of second of water used is less than
The amount of water used in first time merges decoction liquor, and filtration, being concentrated under reduced pressure into and measuring relative density at 60 DEG C is 1.20-1.25's
Clear cream is added auxiliary material, pill, tablet, granule, capsule, powder, film, oral solution is made.
Side's solution of the present invention:
Trigone: it is bitter, it puts down.With blood-breaking, , Zhi lumps in the chest and abdomen the effect of promoting the circulation of qi, clearing stagnation and killing pain, qi and blood coagulates band, trusted subordinate's pain, under the side of body
Swollen pain, menostasis, postpartum blood stasis abdominal pain, traumatic injury, sore swells are hard, have synergistic effect with curcuma zedoary.
Curcuma zedoary: pungent, bitter, temperature.Return liver, the spleen channel；With promoting the circulation of qi blood-breaking, clearing stagnation and killing pain, promoting qi circulation and relieving pain, blood-breaking disperse accumulation helps digestion
The effect for changing product, in abdominal mass and lump, blood stasis closed, dyspepsia distending pain, treating swelling and pain by traumatic injury, early cervical carcinoma, oil of zedoary turmeric removes can be directly
Outside cytotoxicity, moreover it is possible to enhance oncocyte immunogenicity, to induce or promote body to the immunological rejection of tumour.
Radix Astragali: sweet, warm.Have the function of invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema.Contain Huang in Radix Astragali
Ketone, saponin constituents, flavones ingredient such as formononetin, 3'- hydroxyl formononetin (calycosin) and its glucose
Glucoside, 2', 3'- dihydroxy -7,4'- dimethoxy isoflavones, the different Radix Astragali flavane of 7,2'- dihydroxy -3', 4'- dimethoxy and its
Glycoside, 7,3'- dihydroxy -4', 5'- dimethoxy isoflavan, 3-hydroxy-9,10-dimethoxy pterocarpane and its grape
Glucoside etc., some of them ingredient have stronger antioxidant activity, moreover it is possible to enhance body's immunity, enhancing hematopoiesis function, improve
Metabolism, enhancing gonad function, delay senescence the effects of, Radix Astragali also have heart tonifying, adjust blood pressure, antiviral property myocarditis,
The effects of liver protection, antiulcer, improves cellular immune function, can inhibit growth of cancer cells, has enhancing immunity of organism function well
The effect of energy.
Radix scrophulariae: sweet, bitter, slightly cold.With clearing heat and cooling blood, purging fire for removing toxin, the function of enriching yin.Cure mainly warm heat disease heat and ying blood,
Body heat, polydipsia, tongue be deep red, macular eruption, hectic fever due to yin labor is coughed, dysphoria not puckery dim-sighted, the throat larynx swelling and pain of awake, Tianjin hinder constipation, mesh, scrofula subcutaneous nodule,
Skin sore.Containing alkaloids in radix scrophulariae, carbohydrate, sterol, amino acid, fatty acid, volatile oil, carrotene and retinoid object
Matter can enhance body's immunity, improve metabolism.
Kuh-seng: it is bitter, it trembles with fear.Heat-clearing and damp-drying drug；Wind dispelling insecticide.Main damp-heat dysentery；Hematochezia；Jaundice；Difficult urination；Oedema；
Leukorrhagia；Pruritus vulvae；Scabies；Leprosy；Pruitus；Wet poison sore.Contain alkaloid: matrine (matrine), oxymatrine in root
(oxymatrine), sophocarpine (Sophocarpine), matrine have anticancer activity, matrine, oxymatrine, sophocarpine
(Sophocarpine) apparent inhibiting effect is showed for tumour
Prunella vulgaris: bitter, acrid, cold.It is mostly used to carry out mass dissipating and swelling eliminating, controls scrofula, goiter, acute mastitis swelling and pain." new compilation of materia medica " carries it: controlling scrofula
Scrofula, mouse fistula, goiter, disease heavily fortified point, acute mastitis, mammary cancer.Prunella vulgaris is the key medicine of clearing away the liver-fire, Disperse hepatic depression, and what it was cured mainly is Liver Channel mostly
Illness.This product is equipped with chrysanthemum, cassia seed, can clear liver and improve vision, and controls red eye, swell pain, is equipped with the shell of seaear, uncaria, can pancake liver-yang,
Control headache, dizziness；Be equipped with the product such as radix scrophulariae, fritillaria, oyster, can resolving hard lump, control scrofula and go through tuberculosis.In recent years clinically again for swelling
Tumor.
Radix Angelicae Sinensis: root contains volatile oil, and the main component of volatile oil has: butylidenephthalide, the positive pentanone of adjacent carboxyl benzene and dihydro phthalein
Acid anhydride.Have the effects that it is antitumor, improve immunity, anti-inflammatory.It cures mainly and enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturizing dryness and lubricating intestine.The main deficiency of blood is all
Card；Irregular menstruation；Menostasis；Dysmenorrhea；Abdominal mass knot is poly-；Metrorrhagia and metrostaxis；Asthenia cold abdominalgia；Flaccidity syndrome and arthralgia syndrome；Numbness；Intestines are dry and shit is difficult；Weight after dysentery with bloody stool；
Ulcer sores；Injury from falling down.
Radix Salviae Miltiorrhizae: it is bitter, it is slightly cold.Stasis-dispelling and pain-killing, blood circulation, relieving restlessness and restlessness.For irregular menstruation, amenorrhea and algomenorrhea, abdominal mass product
It is poly-, chest and abdomen shouting pain, hot numbness pain, sore and ulcer, swelling and pain, upset and sleepless；Hepatosplenomegaly, angina pectoris.Radix Salviae Miltiorrhizae contains tanshinone, to a variety of
Tumour cell has growth inhibition, apoptosis-induced effect, and antitumor action is to promote tumour by inhibiting tumor cell proliferation
What Apoptosis was realized.
Rhizoma Chuanxiong: blood-activating and qi-promoting, wind-expelling pain-stopping.For irregular menstruation, amenorrhea and algomenorrhea , abdominal mass and abdominal pain, pricking pain in the chest is fallen and is flutterred
Swelling and pain, headache, rheumatic arthralgia, while blood rheology parameter can be made to be intended to normally, inhibit platelet aggregation, promote fiber egg
White dissolution improves microcirculation, and then inhibits the diffusion and transfer of tumour cell.
Oldenlandia diffusa: clearing heat and detoxicating, dampness removing.Cure mainly dyspnea and cough due to lung-heat, abscess of throat, acute appendicitis, furuncle sore, poisonous snake stings
Wound, puckery pain of heat gonorrhea, oedema, dysentery, enteritis, jaundice with damp-heat pathogen are good at a variety of cancerous swellings for the treatment of.
Radix Glycyrrhizae: root and rhizomes contain glycyrrhizin, and containing a small amount of liquiritin, dihydroxy enoxolone, licoricidin,
Glycyrol, 5-0- methyl glycyrol, isoglycyrol, in addition, still containing mannitol, glucose, sucrose, malic acid, betulinic acid, day
Winter amide, Yan acid, life element.With anti-inflammatory antiviral Anti-bacterium effect.It cures mainly and invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing delays
Anxious analgesic.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction, carbuncle sore tumefacting virus, delay
Drug toxicity, strong is solved, and carcinogenic eubolism can be interfered and inhibit its carcinogenesis.
Sculellaria barbata: it is pungent, bitter, it trembles with fear.It is clearing heat and detoxicating；Dissipating stasis and stanching bleeding；Inducing diuresis to remove edema.Main heat toxin carbuncle swells；It has sore throat；Pulmonary abscess；
Acute appendicitis；Scrofula；Venomous snake bite；Traumatic injury；It spits blood；Bleeding from five sense organs or subcutaneous tissue；Blood strangury；Oedema；Ascites and cancer.Scutellaria Barbata D. Don Polysaccharides can promote
The activation of cell, proliferation form antineoplastic immune regulated and control network, achieve the purpose that antitumor to improve cellular immune function.
The tuber of pinellia: acrid in flavour and warm in nature.It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo,
Phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus.The dilute alcohol or water-leach liquor of pinellia pedatisecta Schott, to zoopery tumour and
Hela cell all significantly inhibits.The trigonelline obtained from water portion also has obvious suppression to rat liver cancer (HCA)
Production is used.Sitosterolum contained by it and the like also has tumor-inhibiting action.And obviously cancer cell can be promoted gradually to fall off and make corpus carcinosus
It reduces or disappears.Clinical pharmacology observation, it is effective to cervical carcinoma, and local cleaning action is obvious.
Radix scutellariae: it is bitter, it trembles with fear.Heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention.For damp-warm syndrome, heat temperature chest tightness and emesis, damp and hot ruffian
Completely, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, threatened abortion, radix scutellariae principle active component are
Flavone compound has antibacterial, antiviral effect.
Fructus Forsythiae: it is bitter, it is slightly cold.With clearing heat and detoxicating, dispelling wind and heat from the body, the effect of mass dissipating and swelling eliminating.Clearing heat and eliminating phlegm, powder detoxifcation.
Safflower: safflower contains carthamin yellow and carthamin.Carthamin is hydrolyzed through hydrochloric acid, obtains glucose and carthamin.Also contain
15 α, 20 beta-dihydroxies-Δ 4- pregnene -3- ketone.Separately still fatty oil claims safflower oil, is palmitinic acid, stearic acid, arachidic acid, oil
The glyceride type of acid, linoleic acid, linolenic acid etc..With anti-inflammatory effect.Cure mainly blood circulation, removing blood stasis and acesodyne.For menostasis, pain
Through, lochia, abdominal mass lump in the abdomen, injury from falling down, sore swell and ache curative, while blood physicochemical property can be improved, prevent cancer metastasis.
Radix Codonopsis: there is the effect of tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung.Modern study, Radix Codonopsis containing various saccharides, phenols, sterol,
Volatile oil, scutellarein glucosid, saponin and Alkaloid have strengthen immunity, expansion blood vessel, decompression, improve micro- follow
The effects of ring, enhancing hematopoiesis function.Furthermore there is castering action to the decline of leucocyte caused by chemotherapy radiotherapy.Radix Codonopsis can be enhanced
The resistance of body enhances body's immunity, and Radix Codonopsis also has back mutation effect, to contain the development of tumour.
Rhizoma Atractylodis Macrocephalae: Rhizoma Atractylodis Macrocephalae can destroy cancer cell structure, inhibit growth of cancer cells, cancer cell can be made to be condensed into agglomerate and destroy cancer
The normal configuration of cell has the effect of direct killing tumour cell, while Rhizoma Atractylodis Macrocephalae has the proliferation rate for reducing tumor tissue, and it is thin to lower tumor
The invasion of born of the same parents improves the antitumor respond of body and the cytotoxicity to oncocyte, and is acted on by Rhizoma Atractylodis Macrocephalae back mutation,
It prevents the Preventive of tumour, treatment late malignant tumour is had a better effect.
Radix bupleuri: it is bitter, it is slightly cold.Anti-inflammatory with antipyretic-antalgic, anti-bacteria and anti-virus, antiulcer enhances immune function, antitumor
Effect.
Radix Isatidis: it is bitter, it trembles with fear.It is clearing heat and detoxicating, cool blood relieving sore-throat.For febrile virulent maculae, tongue is dark reddish purple dark, mumps, sore throat, and rotten larynx is red
Acute diseases such as cholera and sunstroke, major part pestilence, erysipelas, carbuncle swells.
Fritillaria thunbergii: it is bitter, it trembles with fear.Control cough due to wind-heat evil, lung carbuncle larynx numbness, scrofula, sore swollen toxin.Bulb contains peimine
(verticine) i.e. peimine (peimine), peiminine (verticinone) i.e. Peininine
(peiminine), peimine and Peininine have obvious inhibiting effect for the drug resistance of mdr cell.
Radix ranunculi ternati: sweet, acrid, warm.With dissipating bind, the effect of detumescence；It does not burst for scrofula, scrofula, pulmonary tuberculosis, leaching
Fawn on tuberculosis, lymphnoditis, sphagitis.
Poria cocos: it is sweet, light, it is mild-natured.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel；With clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative
The effect of, Poria cocos can by influencing macrophage, lymphocyte or other cells and humoral factor to kill cancer cell, some at
Immunity of organisms can also directly be improved by, which dividing, reinforces the resistance to cancer cell to improve whole immune function, can also reinforce resisting
The effect of cancer medicament.
Nidus vespae: sweet and neutral.Poison, desinsection are attacked in wind-dispelling.Control frightened epilepsy, wandering arthritis, urticaria itch, acute mastitis, serious case of furuncle, scrofula, hemorrhoid
Leakage, acute toothache, favus of the scalp, bee sting swollen pain.
The fruit of glossy privet: it is bitter, it puts down.Nourishing liver and kidney, strong waist and knee.Yin asthenia generating intrinsic heat is controlled, dizzy, mesh flower, tinnitus, soreness and weakness of waist and knees, beard and hair morning
It is white.It is nourishing liver and kidney, improving eyesight black hair.For dizziness and tinnitus, soreness and weakness of waist and knees, poliosis, mesh are secretly unknown.The fruit of glossy privet can enhance cell
Immune function, the oleanolic acid contained have tumor-inhibiting action.
Radix Paeoniae Alba: it is bitter, it is slightly cold.Calming the liver and relieving pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For headache and dizziness, hypochondriac pain, abdominal pain, four limbs contraction
Bitterly, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat.Paeoniflorin has antibacterial, antipyretic, anti-inflammatory, increase coronary flow, improvement
Myocardial nutritional flow, confrontation acute myocardial ischemia, inhibits platelet aggregation, calmness, analgesia, spasmolysis, resists and burst expansion blood vessel
Ulcer, the effect for adjusting blood glucose.
Wherein:
(1) antitumor: trigone, curcuma zedoary, kuh-seng, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, oldenlandia diffusa, Sculellaria barbata, the tuber of pinellia, Radix Codonopsis, white
Art, radix bupleuri, Poria cocos, nidus vespae, the fruit of glossy privet；
(2) enhance immune function: Radix Astragali, radix scrophulariae, Sculellaria barbata, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, radix bupleuri, Poria cocos, the fruit of glossy privet；
(3) Malignant tumor of bonal metastasis, diffusion: trigone, curcuma zedoary, Rhizoma Chuanxiong, safflower are prevented；
(4) back mutation: Radix Codonopsis, Rhizoma Atractylodis Macrocephalae；
(5) reversing drug resistance: curcuma zedoary, kuh-seng, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix scutellariae, safflower, Radix Isatidis, fritillaria thunbergii；
(6) clearing heat and detoxicating: radix scrophulariae, Prunella vulgaris, oldenlandia diffusa, Radix Glycyrrhizae, Sculellaria barbata, radix scutellariae, Fructus Forsythiae, radix bupleuri, Radix Isatidis, dew
Honeycomb；
(7) activating microcirculation and removing stasis medicinal: trigone, curcuma zedoary, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, safflower；
(8) reducing phlegm and resolving masses: radix scrophulariae, Prunella vulgaris, the tuber of pinellia, radix bupleuri, fritillaria thunbergii, radix ranunculi ternati, the fruit of glossy privet, Radix Paeoniae Alba；
(9) dispersing stagnated hepatoqi, swelling and pain relieving: Prunella vulgaris, radix bupleuri, radix ranunculi ternati, nidus vespae, the fruit of glossy privet, Radix Paeoniae Alba；
(10) tonifying middle-Jiao and Qi, invigorating spleen and reinforcing stomach: Radix Astragali, Radix Glycyrrhizae, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria cocos；
(11) nourishing yin and supplementing blood: Radix Astragali, radix scrophulariae, Radix Angelicae Sinensis, Radix Codonopsis.
The beneficial effects of the invention are as follows clearing heat and detoxicating, mass dissipating and swelling eliminating, eliminating dampness and eliminating phlegm, invigorating the spleen qi-regulating, activating microcirculation and removing stasis medicinal, promoting the circulation of qi to stop
The effect of pain, eliminates cancer and makes, improve immunity of organisms, prevent Malignant tumor of bonal metastasis and recurrence to inhibit or kill cancer cell,
It can be clinically used for treatment lymthoma.Above-mentioned formula is not only the experiment proved that have good therapeutic effect, and prescription to lymthoma
Simply.
The specific embodiment of the invention is described with reference to the accompanying drawings and embodiments.
Detailed description of the invention
Fig. 1 is the inhibiting effect figure of a pair of of embodiment of the present invention transplanted tumor in nude mice knurl weight；
Fig. 2 is the efficacy result figure of the embodiment of the present invention one.
Specific embodiment
This specific embodiment is only explanation of the invention, is not limitation of the present invention, those skilled in the art
Member can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but as long as at this
All by the protection of Patent Law in the scope of the claims of invention.
Embodiment 1: by 20 parts of trigone, 15 parts of curcuma zedoary, 30 parts of Radix Astragali, 35 parts of radix scrophulariae, 10 parts of kuh-seng, 20 parts of Prunella vulgaris, when
Return 15 parts, 35 parts of Radix Salviae Miltiorrhizae, 25 parts of Rhizoma Chuanxiong, 20 parts of oldenlandia diffusa, 10 parts of Radix Glycyrrhizae, 20 parts of Sculellaria barbata, 10 parts of the tuber of pinellia, radix scutellariae 20
Part, 20 parts of Fructus Forsythiae, 15 parts of safflower, 35 parts of Radix Codonopsis, 20 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of radix bupleuri, 15 parts of Radix Isatidis, 15 parts of fritillaria thunbergii, radix ranunculi ternati
15 parts, 10 parts of Poria cocos, 20 parts of nidus vespae, 25 parts of the fruit of glossy privet, 25 parts of Radix Paeoniae Alba, add water to cook it is secondary, 1 hour every time, for the first time 6
Amount water again, second of 4 times of amount water merge decoction liquor, and filtration is concentrated under reduced pressure at 60 DEG C and measures relative density as 1.20-
1.25(55 DEG C) clear cream, it is dry (drying temperature is 60 DEG C), be ground into fine powder, be sieved.
Embodiment 2: by 15 parts of trigone, 30 parts of curcuma zedoary, 20 parts of Radix Astragali, 25 parts of radix scrophulariae, 15 parts of kuh-seng, 30 parts of Prunella vulgaris, when
Return 20 parts, 30 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 60 parts of oldenlandia diffusa, 30 parts of Radix Glycyrrhizae, 30 parts of Sculellaria barbata, 20 parts of the tuber of pinellia, radix scutellariae 15
Part, 15 parts of Fructus Forsythiae, 20 parts of safflower, Radix Codonopsis 45,25 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of radix bupleuri, 30 parts of Radix Isatidis, 10 parts of fritillaria thunbergii, radix ranunculi ternati 25
Part, 35 parts of Poria cocos, 25 parts of nidus vespae, 60 parts of the fruit of glossy privet, 20 parts of Radix Paeoniae Alba, add water to cook it is secondary, 1 hour every time, for the first time 6 times
Water is measured, second of 4 times of amount water merges decoction liquor, and filtration, being concentrated under reduced pressure at 60 DEG C and measuring relative density is 1.20-1.25
The clear cream of (55 DEG C), it is dry (drying temperature is 60 DEG C), it is ground into fine powder, is sieved.
Embodiment 3: by 30 parts of trigone, 25 parts of curcuma zedoary, 60 parts of Radix Astragali, 50 parts of radix scrophulariae, 20 parts of kuh-seng, 50 parts of Prunella vulgaris, when
Return 30 parts, 60 parts of Radix Salviae Miltiorrhizae, 30 parts of Rhizoma Chuanxiong, 30 parts of oldenlandia diffusa, 20 parts of Radix Glycyrrhizae, 35 parts of Sculellaria barbata, 15 parts of the tuber of pinellia, radix scutellariae 30
Part, 30 parts of Fructus Forsythiae, 30 parts of safflower, 60 parts of Radix Codonopsis, 30 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of radix bupleuri, 25 parts of Radix Isatidis, 30 parts of fritillaria thunbergii, radix ranunculi ternati
30 parts, 15 parts of Poria cocos, 30 parts of nidus vespae, 15 parts of the fruit of glossy privet, 30 parts of Radix Paeoniae Alba, add water to cook it is secondary, 1 hour every time, for the first time 6
Amount water again, second of 4 times of amount water merge decoction liquor, and filtration is concentrated under reduced pressure at 60 DEG C and measures relative density as 1.20-
1.25(55 DEG C) clear cream, it is dry (drying temperature is 60 DEG C), be ground into fine powder, be sieved.
Embodiment 4: by 20 parts of trigone, 15 parts of curcuma zedoary, 30 parts of Radix Astragali, 35 parts of radix scrophulariae, 10 parts of kuh-seng, 20 parts of Prunella vulgaris, when
Return 15 parts, 35 parts of Radix Salviae Miltiorrhizae, 25 parts of Rhizoma Chuanxiong, 20 parts of oldenlandia diffusa, 10 parts of Radix Glycyrrhizae, 20 parts of Sculellaria barbata, 10 parts of the tuber of pinellia, radix scutellariae 20
Part, 20 parts of Fructus Forsythiae, 15 parts of safflower, 35 parts of Radix Codonopsis, 20 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of radix bupleuri, 15 parts of Radix Isatidis, 15 parts of fritillaria thunbergii, radix ranunculi ternati
15 parts, 10 parts of Poria cocos, 20 parts of nidus vespae, 25 parts of the fruit of glossy privet, 25 parts of Radix Paeoniae Alba, add water to cook it is secondary, 2 hours every time, for the first time 10
Amount water again, second of 8 times of amount water merge decoction liquor, and filtration is concentrated under reduced pressure at 60 DEG C and measures relative density as 1.20-
1.25(55 DEG C) clear cream, it is dry (drying temperature is 60 DEG C), be ground into fine powder, be sieved.
Embodiment 5: by 15 parts of trigone, 30 parts of curcuma zedoary, 20 parts of Radix Astragali, 25 parts of radix scrophulariae, 15 parts of kuh-seng, 30 parts of Prunella vulgaris, when
Return 20 parts, 30 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 60 parts of oldenlandia diffusa, 30 parts of Radix Glycyrrhizae, 30 parts of Sculellaria barbata, 20 parts of the tuber of pinellia, radix scutellariae 15
Part, 15 parts of Fructus Forsythiae, 20 parts of safflower, Radix Codonopsis 45,25 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of radix bupleuri, 30 parts of Radix Isatidis, 10 parts of fritillaria thunbergii, radix ranunculi ternati 25
Part, 35 parts of Poria cocos, 25 parts of nidus vespae, 60 parts of the fruit of glossy privet, 20 parts of Radix Paeoniae Alba, add water to cook it is secondary, 2 hours every time, for the first time 10 times
Water is measured, second of 8 times of amount water merges decoction liquor, and filtration, being concentrated under reduced pressure at 60 DEG C and measuring relative density is 1.20-1.25
The clear cream of (55 DEG C), it is dry (drying temperature is 60 DEG C), it is ground into fine powder, is sieved.
Embodiment 6: by 30 parts of trigone, 25 parts of curcuma zedoary, 60 parts of Radix Astragali, 50 parts of radix scrophulariae, 20 parts of kuh-seng, 50 parts of Prunella vulgaris, when
Return 30 parts, 60 parts of Radix Salviae Miltiorrhizae, 30 parts of Rhizoma Chuanxiong, 30 parts of oldenlandia diffusa, 20 parts of Radix Glycyrrhizae, 35 parts of Sculellaria barbata, 15 parts of the tuber of pinellia, radix scutellariae 30
Part, 30 parts of Fructus Forsythiae, 30 parts of safflower, 60 parts of Radix Codonopsis, 30 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of radix bupleuri, 25 parts of Radix Isatidis, 30 parts of fritillaria thunbergii, radix ranunculi ternati
30 parts, 15 parts of Poria cocos, 30 parts of nidus vespae, 15 parts of the fruit of glossy privet, 30 parts of Radix Paeoniae Alba, add water to cook it is secondary, 2 hours every time, for the first time 10
Amount water again, second of 8 times of amount water merge decoction liquor, and filtration is concentrated under reduced pressure at 60 DEG C and measures relative density as 1.20-
1.25(55 DEG C) clear cream, it is dry (drying temperature is 60 DEG C), be ground into fine powder, be sieved.
Effect of the invention is illustrated only with the Chinese materia medica preparation that embodiment 1 is prepared.
Further effect of the invention is illustrated using animal experiment and clinical test below.
One, animal experiment
1, acute toxicity testing
1.1 animal subjects: Kun Ming mice, about 20 grams every, half male and half female.
1.2 test medicines: distilled water is added in medicinal powder made of the embodiment of the present invention 1 on a small quantity, heating stirring is prepared into mixed
Suspension.
1.3 tested processes: mouse is randomly divided into two groups, and every group 30, i.e. control group and administration group test preceding fasting 12
Hour；Stomach-filling volume is that 5ml/kg(i.e. unit dosage form is 28.7 crude drugs/kg), every stomach-filling in 4 hours is primary, and single oral gavage holds
Amount is every 0.5mL, is continuously gavaged three times, and gavaging total capacity daily is every 1.5mL, and always gavaging dosage daily is 86.1 raw
Medicine/kg/ days, control group gave same amount of normal saline, is administered 3 times within one day, delivery time 4 hours, is observed continuously after administration
14 days, record the toxic reaction and death toll of mouse.
The results showed that compared with the control group, mouse has no notable difference after administration, and experiment is observed continuously 14 days, small
Mouse body condition, diet, drinking water and weight gain is normal.It can be seen that Chinese materia medica preparation acute toxicity of the invention is low, it is clinical
Drug safety.
2, long term toxicity test
2.1 animal subjects: SD rat, about 200 grams every, half male and half female.
2.2 test medicines: distilled water is added in powder made of the embodiment of the present invention 1 on a small quantity, heating stirring is prepared into suspension
Liquid.
2.3 tested processes:
Suspension made of the embodiment of the present invention 1, embodiment 2, embodiment 3 is pressed into 10.78,20.35 and to mouse respectively
33.48g crude drug/kg continuous use 16 weeks (1.0mL/100g weight, 2 times a day) and be discontinued 4 weeks after mouse is observed,
Detection.
The results showed that Chinese materia medica preparation of the present invention is to the hair of rat, behavior, stool and urine, weight, organ weights, blood
As, indexs such as hepatic and renal function, blood glucose, blood lipid all have no significant effect, internal organs naked eyes are without finding abnormal variation and histological examination
The result shows that each internal organs of rat nothing is substantially change after medication 16 weeks and drug withdrawal 4 weeks.Illustrate Chinese materia medica preparation of the present invention to rat
Small toxicity after long-term administration, also without abnormal reaction after drug withdrawal, application is safe.
3, tumor-inhibiting action is tested
3.1 animal subjects: ICR mouse 100,19-24g of weight, male.
3.2 experimental materials: murine sarcoma S180。
3.3 test medicines: distilled water is added in powder made of the embodiment of the present invention 1 on a small quantity, heating stirring is prepared into suspension
Liquid.
Inhibition test in 3.4 bodies:
Each mouse right fore armpit inoculates murine sarcoma S180Cell suspension 0.2mL.Next day is randomly divided into five groups: physiology salt
Water group, test medicine low, middle and high dose groups, positive controls (5-Fu 20mg/kg), every group 20.After inoculation for 24 hours, each group
Intragastric administration on mice is given tried drug (positive controls use intraperitoneal injection), continuous 10 days, in last dose for 24 hours after,
Test mice is weighed, then cervical dislocation is put to death, and removes tumor tissue, electronic balance weighing, and calculate tumour inhibiting rate (%).
The inhibiting effect of 3.5 pairs of transplanted tumor in nude mice knurl weights is shown in Fig. 1.
Group dosage (/kg) knurl weight (g) tumour inhibiting rate (%)
High dose group 33.48g crude drug 1.4 ± 0.3 40.7
Middle dose group 20.35g crude drug 1.5 ± 0.4 38.5
Low dose group 10.78g crude drug 1.6 ± 0.5 36.8
Positive controls 38.7g crude drug 1.5 ± 0.2 38.9
Physiological saline group/2.6 ± 0.6/
It will be seen from figure 1 that each dosage group of Chinese medicine of the present invention can significantly inhibit knurl weight compared with physiological saline group and comparative example 1
(P < 0.05), tumor killing effect is suitable with tumor effect is inhibited, and shows that Chinese medicine anti-lymphadenoma effect of the present invention is significant.
Two, clinical test
1, clinical case
Test patient totally 100, wherein male 50, are suffering from lymthoma, implementation of the present invention are taken during treatment by women 50
The medicinal powder that example 3 is prepared, warm water take, and three times a day, a 6g, treatment cycle is 4 courses for the treatment of, each course for the treatment of 30 days.
2, criterion of therapeutical effect
It is effective: symptom complete incidence graph or disappearance；
It improves: referring to that symptom part is alleviated；
It is invalid: without any effect after treatment.
3, experimental result
It is specifically shown in Fig. 2.
The treatment time invalid number of cases total effective rate of effective number of cases improvement number of cases
One course for the treatment of 23 52 25 75%
Two courses for the treatment of 31 51 18 82%
Three courses for the treatment of 51 37 12 88%
Four courses for the treatment of 65 28 10 90%
Figure it is seen that Chinese medicine total effective rate of the invention is high, 91% can be reached after four courses for the treatment of, it can be in a short time
It is obviously reduced lump, effectively control diffusion increases the ratio of clinical cure patient, and passes through clinical observation, daily patient's patient's condition
Inquiry is summarized and regularly x-ray, CT or ultrasound diagnosis etc., determines that Chinese medicine of the invention quickly can mitigate or disappear in a short time
Except patient symptom, mitigate patient suffering, stablizes the state of an illness.
Claims (5)
1. a kind of Chinese medicine composition for treating lymthoma, which is characterized in that Chinese medicine material medicine according to parts by weight are as follows: trigone 20-
30 parts, 15-30 parts of curcuma zedoary, 20-60 parts of Radix Astragali, 25-50 parts of radix scrophulariae, 10-20 parts of kuh-seng, 20-50 parts of Prunella vulgaris, Radix Angelicae Sinensis 15-30
Part, 30 parts -60 parts of Radix Salviae Miltiorrhizae, 20-30 parts of Rhizoma Chuanxiong, 20-60 parts of oldenlandia diffusa, 10-30 parts of Radix Glycyrrhizae, 20-35 parts of Sculellaria barbata, the tuber of pinellia
10-30 parts, 15-30 parts of radix scutellariae, 15-30 parts of Fructus Forsythiae, 15-30 parts of safflower, 35 parts -60 parts of Radix Codonopsis, 20-30 parts of Rhizoma Atractylodis Macrocephalae, radix bupleuri 20-
30 parts, 15-30 parts of Radix Isatidis, 10-30 parts of fritillaria thunbergii, 15-30 parts of radix ranunculi ternati, 10-35 parts of Poria cocos, 20-30 parts of nidus vespae, glossy privet
It is 15-60 parts sub-, 20-30 parts of Radix Paeoniae Alba.
2. a kind of Chinese medicine composition for treating lymthoma according to claim 1, which is characterized in that according to parts by weight
Medicine bulk pharmaceutical chemicals are as follows: 20 parts of trigone, 15 parts of curcuma zedoary, 30 parts of Radix Astragali, 35 parts of radix scrophulariae, 10 parts of kuh-seng, 20 parts of Prunella vulgaris, 15 parts of Radix Angelicae Sinensis,
35 parts of Radix Salviae Miltiorrhizae, 25 parts of Rhizoma Chuanxiong, 20 parts of oldenlandia diffusa, 10 parts of Radix Glycyrrhizae, 20 parts of Sculellaria barbata, 10 parts of the tuber of pinellia, 20 parts of radix scutellariae, Fructus Forsythiae 20
Part, 15 parts of safflower, 35 parts of Radix Codonopsis, 20 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of radix bupleuri, 15 parts of Radix Isatidis, 15 parts of fritillaria thunbergii, 15 parts of radix ranunculi ternati, Poria cocos
10 parts, 20 parts of nidus vespae, 25 parts of the fruit of glossy privet, 25 parts of Radix Paeoniae Alba.
3. a kind of Chinese medicine composition for treating lymthoma according to claim 1, which is characterized in that according to parts by weight
Medicine bulk pharmaceutical chemicals are as follows: 15 parts of trigone, 30 parts of curcuma zedoary, 20 parts of Radix Astragali, 25 parts of radix scrophulariae, 15 parts of kuh-seng, 30 parts of Prunella vulgaris, 20 parts of Radix Angelicae Sinensis,
30 parts of Radix Salviae Miltiorrhizae, 20 parts of Rhizoma Chuanxiong, 60 parts of oldenlandia diffusa, 30 parts of Radix Glycyrrhizae, 30 parts of Sculellaria barbata, 20 parts of the tuber of pinellia, 15 parts of radix scutellariae, Fructus Forsythiae 15
Part, 20 parts of safflower, Radix Codonopsis 45,25 parts of Rhizoma Atractylodis Macrocephalae, 20 parts of radix bupleuri, 30 parts of Radix Isatidis, 10 parts of fritillaria thunbergii, 25 parts of radix ranunculi ternati, Poria cocos 35
Part, 25 parts of nidus vespae, 60 parts of the fruit of glossy privet, 20 parts of Radix Paeoniae Alba.
4. according to a kind of Chinese medicine composition for treating lymthoma described in claim 1, which is characterized in that Chinese medicine according to parts by weight
Bulk pharmaceutical chemicals are as follows: 30 parts of trigone, 25 parts of curcuma zedoary, 60 parts of Radix Astragali, 50 parts of radix scrophulariae, 20 parts of kuh-seng, 50 parts of Prunella vulgaris, 30 parts of Radix Angelicae Sinensis, pellet
Join 60 parts, 30 parts of Rhizoma Chuanxiong, 30 parts of oldenlandia diffusa, 20 parts of Radix Glycyrrhizae, 35 parts of Sculellaria barbata, 15 parts of the tuber of pinellia, 30 parts of radix scutellariae, Fructus Forsythiae 30
Part, 30 parts of safflower, 60 parts of Radix Codonopsis, 30 parts of Rhizoma Atractylodis Macrocephalae, 30 parts of radix bupleuri, 25 parts of Radix Isatidis, 30 parts of fritillaria thunbergii, 30 parts of radix ranunculi ternati, Poria cocos
15 parts, 30 parts of nidus vespae, 15 parts of the fruit of glossy privet, 30 parts of Radix Paeoniae Alba.
5. the preparation method of Chinese medicine composition according to any one of claims 1-4, it includes the following steps: will be described
Starting material with water decocts twice, and 1 to 2 hours every time, the water measured for the first time with 6 to 10 times, second of the water measured with 4 to 8 times,
In second water used amount less than the amount of water used in first time, merge decoction liquor, filtration is concentrated under reduced pressure into and measures at 60 DEG C
Relative density is the clear cream of 1.20-1.25, and auxiliary material is added, and pill is made, tablet, granule, capsule, powder, film, takes orally
Liquid.
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