CN104586874A - Medicine for preventing and treating respiratory tract infection of birds and preparation method thereof - Google Patents
Medicine for preventing and treating respiratory tract infection of birds and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for preventing and treating respiratory tract infection of birds. The medicine comprises the following components: 0.1-1g of ribavirin, 0.25-2.5g of sodium acetylsalicylate, 0.1-1g of mequindox, 0.25-2.5g of sodium carboxymethylcellulose, 0.5-5ml of propylene glycol and 0.5-5ml of Tween-80. The medicine for preventing and treating respiratory tract infection of birds can effectively reduce the incidence rate of the respiratory tract infection of birds and has a good treatment effect, the cure rate is 91.6 percent, and the preparation has wide popularization and application values in clinical application.
Description
Technical field
The present invention relates to and be a kind ofly used for the treatment of medicine of fowl respiratory tract infection and preparation method thereof, belong to field of veterinary.
Background technology
Along with the development of poultry farming, cause the cause of disease of poultry respiratory tract diseases also increasing year by year, make poultry fairly suffer from respiratory tract disease.The physiological characteristics of poultry itself determines that it easily suffers from respiratory tract disease: first, and the main organs that poultry is used for gas exchange is air bag, instead of lungs.Also have opening in its pulmonary, and lung has not expansivity, position is fixed; Secondly, poultry can not cough, and does not have diaphragm, and respiratory tract directly communicates with the external world, is very easily subject to the infringement of extraneous harmful gas, dust, microorganism, causes respiratory tract injury and fall ill.Above two physiological characteristicies determine the susceptibility of poultry to respiratory system disease, are also very easy to the infection suffering pathogenic microorganism, and its pathogenic infection mainly contains following several usually:
1, mycoplasma causes
Modal is more easily diagnosing of being caused by mycoplasma, and chickling easily sends out.Chickling be mostly due to epidemic prevention stress and send out, become that chicken is many brings out because hen house occluded air is muddy, its Symptoms for coughing, ataxia, sneeze.This stage can not cause large loss, but can cause a series of disease along with the development of the state of an illness, common are pneumonia, airsacculitis, peritonitis, pericarditis, perihepatitis, conjunctivitis etc. and then causes death, also can bring out the diseases such as newcastle.So will treat in time at the initial stage of a disease.Many is tylosin and taimulin etc. now, also has a large amount of use antiviral agents and other tracheaectasy medicines, but just takes stopgap measures and do not effect a permanent cure, and because mycoplasma life size is between virus and antibacterial, medication will more than 5 days.And concentration will reach required amount, prevention, then to eliminate inducement, is prevented epidemic when particularly laboring Seedling and will be ensured that chicken group is in health status, note air quality, but first will ensure that house temperature can not have under the prerequisite of too large change.
2, mycoplasma is brought out other diseases and is caused
Mycoplasma brings out pneumonia and airsacculitis, will have influence on feed intake, and middle chicken is the most common.Treatment then should to diminish inflammation, the respiratory symptom that this disease causes is most typical is exactly snore, there is rale, examine and can see that disease chicken is with ventral breathing, stretch neck without diseases such as god, respiratory symptom on the surface, but be actually and caused by pneumonia, airsacculitis and peritonitis, this is sick by the very difficult treatment of colibacillosis, feces is put and can be seen that reddish yellow etc. is variegated in the sun, and just have green feces time serious, at this moment treatment will based on antiinflammatory, select the medicine that responsive penetrating power is strong, Chinese medicine and tracheaectasy medicine impel expectoration to be auxiliary.
3, viral disease causes
The respiratory tract disease caused by virosis, modally caused by atypical newcastle disease, its symptom is dyspnea, has and stretches neck action, broiler paralysis falls, Egg Shell Quality of Layers is deteriorated, and slightly declines, and feed intake can't see obvious minimizing, indivedual chicken is had night to shout strangely, from this, some roughly can be judged as atypical newcastle disease, with good conditionsily can do antibody detection, wants booster immunization for this situation.Other also have laryngotracheitis and larynx pox, occur in the majority with laying hen, and symptom is relatively obvious, and mainly dyspnea, has death in various degree, dissects and easily diagnoses.Available Chinese medicine laryngitis medicine, also can vaccine epidemic prevention.Infectious bronchitis is the respiratory tract disease of a kind of acute, the high degree in contact of chicken.Breathing pattern: the sick chickling within two week age, common nasal sinuses swelling, stream stickiness nose liquid, the symptom such as to shed tears, sick chicken often gets rid of head.After laying hen infects, egg production declines 10% ~ 30%, produces soft-shelled egg, deformity egg or arenaceous shell egg simultaneously, and after 2 ~ 3 weeks, egg production can be gone up gradually, but can not return to premorbid level.Because vaccine immunity is very successful in recent years, so less of this disease.Kidney type: in recent years multiple, in two weeks, chickling often sends out, respiratory symptom is not too obvious, made a definite diagnosis 3 points, kidney and the urate of renal tubules enlargement adularescent, conscience is without urate deposition, indivedual caecum becomes large, adularescent content, the experience of the author be after rehabilitation not laying hen then one piece also do not produce, normal laying hen is then unaffected.Fine treatment, mainly diagnoses in time, treats in time, loses not too large.
4, non-high pathogenic avian influenza causes
The mainly snore of non-high pathogenic avian influenza, there is the underwater sound the same like in larynx, laying hen mainly eggshell quality control breakdown, soft egg increases suddenly, search for food and reduce suddenly, the personal understanding of the author is: influenza is except carrying out necessary epidemic prevention, mainly to improve chicken group holistic health level, it is main for improving body resistivity, do pouity dwelling place insulation construction well, what is particularly worth mentioning is that, when all the flowers burst open in the warm spring often, and morbidity is more, the author thinks that mainly spring, weather was barely warm but still cool, noted logical wind-induced simply.Totally enclosed type hen house is more better, and the morbidity in spring of open hen house is more.
In a word, fowl respiratory tract disease is common, is single generation sometimes, is that mixing occurs sometimes.The generation of fowl respiratory tract disease mainly causes the loss of laying eggs, growth of meat chicken is slow, and feed conversion rate reduces to such an extent as to brings out great disease, so in laying hen Disease epizootic, must first consider to control respiratory tract disease, ensureing that chicken group has a good living environment, for keeping chicken group health to create conditions better, during diagnosis, will Etiological be found, accomplish to see color (feces) daytime, night, audition, early found, early made a definite diagnosis.
Based on the above cause of disease, so above pathogenic factor will be considered on clinical treatment, carry out Comprehensive Treatment.
Summary of the invention
The technical problem to be solved in the present invention overcomes existing defect, provides the medicine for preventing and treating fowl respiratory tract infection that a kind of cure rate is high;
Another object of the present invention is to provide the preparation method of said medicine.
Object of the present invention carrys out specific implementation by the following technical programs:
For preventing and treating a medicine for fowl respiratory tract infection, comprise following component:
Ribavirin 0.1-1g,
Aspirin sodium 0.25-2.5g,
Mequindox 0.1g-1g,
Sodium carboxymethyl cellulose 0.25-2.5g,
Propylene glycol 0.5-5ml,
Tween-80 0.5-5ml。
Further, the above-mentioned medicine for preventing and treating fowl respiratory tract infection, comprises following component:
Ribavirin 0.5g,
Aspirin sodium 1.25g,
Mequindox 0.5g,
Sodium carboxymethyl cellulose 1.25g,
Propylene glycol 2.5ml,
Tween-80 2.5ml。
The process for preparing medicine of above-mentioned treatment fowl respiratory tract infection, comprises the following steps:
1) first Mequindox, Aspirin sodium are added in 100ml deionized water, be heated to dissolve, obtain dosing 1, for subsequent use after placing room temperature;
2) ribavirin is added in 100ml deionized water, then add propylene glycol and Tween-80 respectively, stir, obtain dosing 2.
3) dosing 1 is joined in dosing 2, then add 0.25g sodium carboxymethyl cellulose, after adding deionized water to 1000ml, stir and obtain the medicine for the treatment of fowl respiratory tract infection.
Preferably, in described step 1), heating 1 is little of 80 DEG C.
Preferably, described step 2) in, namely room temperature 200 revs/min of high-speed stirred obtain dosing 2 in 30 minutes.
Preferably, in described step 3), room temperature 200 revs/min of high-speed stirred 10 minutes.
Mequindox in formula of the present invention is an antimicrobial drug, especially to mycoplasma best results.Ribavirin is antiviral drugs, and its respiratory virus infection such as the influenza to fowl, parainfluenza has good effect.Aspirin has antipyretic, analgesia, antiinflammatory, antiheumatic effect.The party selects Aspirin sodium except having acetysalicylic effect, can also play solubilization to Mequindox.Sodium carboxymethyl cellulose propylene glycol, Tween-80: be solubilizing agent.
The medicine for the treatment of fowl provided by the invention respiratory tract infection, can effectively reduce fowl respiratory tract infection sickness rate, and have good therapeutic effect, cure rate reaches 91.6%, and said preparation has wide application value clinically.
Detailed description of the invention
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein is only for instruction and explanation of the present invention, is not intended to limit the present invention.
Medicine of the present invention, called after is anti-rather exhales.
embodiment 1:
Prescription 1: ribavirin 0.1g, Aspirin sodium 0.25g, Mequindox 0.1g, sodium carboxymethyl cellulose 0.25g, propylene glycol 0.5ml, Tween-80 0.5ml.
Preparation method is:
1) first Mequindox 0.1-1g, Aspirin sodium 0.25g are added in 100ml deionized water, heating 800C, within 1 hour, dissolve, obtain dosing 1, for subsequent use after placing room temperature.
2) added in 100ml deionized water by 0.1g-1g ribavirin, then add 0.5ml propylene glycol and 0.5ml Tween-80 respectively, room temperature 200 revs/min of high-speed stirred 30 minutes, obtain dosing 2 for subsequent use.
3) dosing 1 is joined in dosing 2, then add 0.25g sodium carboxymethyl cellulose, after adding the straight 1000ml of deionized water, room temperature 200 revs/min of high-speed stirred 10 minutes.
embodiment 2:
Anti-exhale peaceful prescription 2: ribavirin 0.5g, Aspirin sodium 1.25g, Mequindox 0.5g, sodium carboxymethyl cellulose 1.25g, propylene glycol 2.5ml, Tween-80 2.5ml, add deionized water to 1000ml.
Preparation method is with embodiment 1.
embodiment 3:
Anti-exhale peaceful prescription 3: ribavirin 1g, Aspirin sodium 2.5g, Mequindox 1g, sodium carboxymethyl cellulose 2.5g, propylene glycol 5ml, Tween-80 5ml, add deionized water to 1000ml.
Preparation method is with embodiment 1.
In order to further illustrate essence of the present invention, applicant is to the medicine of above-mentioned three embodiments and contrast groups medicine and blankly organize medicine and carried out following contrast experiment.
Respiratory disease of chicken is a kind of Acute exposure sexually transmitted disease caused by antibacterial or virus.Infectious bronchitis (IB), infectious laryngotracheitis (ILT), infective rhinitis (IC), fowl mycoplasma (CRD) etc. all shows respiratory symptom, main manifestations is that disease chicken stretches neck and shakes the head, sneeze, breathe dyspnea with rapid respiration and cacophonia, eye, nose flow liquid, spirit is tired, loss of appetite etc., cut open the visible respiratory system of inspection in petechia or hyperemia in various degree, inflammatory symptom is obvious, sick chicken also normal with digestive system and other organs as intestinal bleeding, Liver and kidney enlargement, the comprehensive pathological changes such as pericardium inflammation, the general course of disease of respiratory tract disease is longer, have a strong impact on growth of meat chicken and Performance of Laying, heavy losses are caused to aviculture.Make full use of the existing drug resource of China, explore development new drug preparation and the respiratory tract disease such as infectious bronchitis of fowl, infectious laryngotracheitis is treated, to raising fowl culture benefit and animal health control effect significant.
1 materials and methods
1.1 test material
1.1.1 anti-exhale peaceful: Lanzhou Livestock and Animal Drug Inst., Chinese Academy of Agricultural Science develops, and its prescription is respectively anti-and exhales peaceful prescription 1: ribavirin 0.1g, Aspirin sodium 0.25g, Mequindox 0.1g, sodium carboxymethyl cellulose 0.25g, propylene glycol 0.5ml, Tween-80 0.5ml, add deionized water to 1000ml;
Anti-exhale peaceful prescription 2: ribavirin 0.5g, Aspirin sodium 1.25g, Mequindox 0.5g, sodium carboxymethyl cellulose 1.25g, propylene glycol 2.5ml, Tween-80 2.5ml, add deionized water to 1000ml;
Anti-exhale peaceful prescription 3: ribavirin 1g, Aspirin sodium 2.5g, Mequindox 1g, sodium carboxymethyl cellulose 2.5g, propylene glycol 5ml, Tween-80 5ml, add deionized water to 1000ml.
Contrast prescription 1: ribavirin 1g, Aspirin sodium 2.5g, sodium carboxymethyl cellulose 2.5g, propylene glycol 5ml, Tween-80 5ml, add deionized water to 1000ml;
Contrast prescription 2: Aspirin sodium 2.5g, Mequindox 1g, sodium carboxymethyl cellulose 2.5g, propylene glycol 5ml, Tween-80 5ml, add deionized water to 1000ml, preparation method is method as above.
Blank prescription: Aspirin sodium 2.5g, sodium carboxymethyl cellulose 2.5g, propylene glycol 5ml, Tween-80 5ml, add deionized water to 1000ml, preparation method is method as above.
1.1.2 test chicken 10 Japanese instar chickling 300, purchased from Gansu China Gansu Province chicken house.
1.1.3 bacterium (poison) strain haemophilus paragallinarum N strain, avian infectious bronchitis virus M41 strain, be derived from China Veterinery Drug Inspection Office.
1.2 test method
1.2.1 raw material prepares
Prepared according to above method by this medicine, load in clean turnover barrel, sealing, proceeds to room to be checked to be checked.Detect qualified after, put powder automatic packer by regulation subpackage, sealing.
1.2.2 antibacterial culturing
Haemophilus paragallinarum is inoculated in the chicken serum chicken soup culture medium containing 2% Sanguis caprae seu ovis Lactoferrin, cultivates 24 h, according to a conventional method count plate for 37 DEG C.
1.2.3 M41 strain EID50 measures
Poison 100 times of dilutions will be planted, be inoculated in 10 age in days chick embryo allantoic cavities, every embryo 0.1 mL, and hatch 48 h for 37 DEG C, get allantoic fluid for subsequent use and observe embryonic lesions.
1.2.4 counteracting toxic substances dosimetry
Get test chicken 20, random point 4 groups, per nasal, eye instillation IBV and haemophilus paragallinarum equivalent mixed liquor 0.1,0.2,0.3,0.4 mL, observe chicken incidence after counteracting toxic substances respectively.
1.3 anti-exhale peaceful to respiratory disease of chicken therapeutic test
1.3.1 test grouping and process 10 age in days chicken 300, be divided into 6 groups at random, often organize 50, be respectively anti-and exhale peaceful 3,2,1 groups, matched group, and every chicken infects contamination by the counteracting toxic substances dosage per nasal determined, eye instillation.Test chicken is 24 h after counteracting toxic substances, exhaling peaceful dosage drinking water administration respectively, being used in conjunction 5 d by adding the anti-of 2ml in often liter of drinking-water.After drug control group counteracting toxic substances, 24 h are by often liter of 2ml drinking water administration, and method is the same.
1.3.2 efficacy assessment standard
Duration of test, observes chicken group every day, adds up effective percentage, mortality rate and body weight increase rate after the course for the treatment of.
1.4 anti-exhale peaceful and the comparative test of powder therapeutic effect
1.4.1 test grouping and will be divided into 3 groups for examination chicken, exhale peaceful group, 1500 for anti-, by the dosage drinking water administration of 2ml/kg, be used in conjunction 5d for the 1st group; 2nd, 3 groups is matched group, 1500, by the dosage drinking water administration of 2ml/kg, is used in conjunction 5d.
2 results
2.1 anti-therapeutic effect of exhaling rather to respiratory disease of chicken
2.1.1 counteracting toxic substances dosage
After haemophilus paragallinarum 37 DEG C cultivates 24 h, count plate is 20 × 108CFU/mL.The ELD50 of avian infectious bronchitis virus M41 strain is 10-6.5/0.1 mL.Chicken 48h after counteracting toxic substances falls ill successively, wherein 0.2-0.4 mL group all morbidities, therefore determines that 0.2 mL/ is only counteracting toxic substances dosage.
2.1.2 counteracting toxic substances sequela chicken symptom
34-38 h after counteracting toxic substances, positive controls is fallen ill successively, performance dyspnea, shed tears, the symptom such as sneeze, 98 h occur dead.After death cut open the swelling of inspection visible chicken face, eye conjunctivitis, edema, nasal cavity has mucus secretions, and trachea has mucus exudate, and air bag is muddy.Chicken pathogen separation of dying of illness is positive.
2.1.3 resist and exhale peaceful efficacy result
As can be seen from Table 1, anti-peaceful each test group chicken survival number, the treated effect of exhaling all higher than matched group, and anti-ly exhales peaceful 2 groups and anti-ly exhale peaceful 3 groups all to exhale peaceful 1 higher than anti-.Resisting exhales peaceful 2 test group body weight increase rate higher than other groups, integrated cost and animal safety factor, and selection condition is anti-exhales peaceful 2 groups to be optimum formula.
Table 1 is anti-exhales the peaceful therapeutic effect to respiratory disease of chicken
。
2.2 anti-exhale peaceful 2 with contrast medicine therapeutic effect and compare
The results are shown in Table 2.From table 2, the anti-cure rate of peaceful 2 groups of morbidity chickens of exhaling is higher than matched group, and the remarkable matched group group of mortality rate; Resisting exhales the average weight gain of peaceful 2 and the relative weight gain to be significantly higher than matched group.
Table 2 is anti-exhale peaceful 2 with contrast medicine therapeutic effect and compare
。
3 discuss
3.1 find out from result of the test, and resist and exhale the sickness rate of peaceful 1,2,3 group greatly to reduce than positive controls sickness rate respectively, situation increases.Considering No. 2 prescriptions is best prescription.
3.2 according to this result of the test, and resist and exhale peaceful clinical recommendation consumption to be 2-4 ml/kg drinking water administration, 5d is a course for the treatment of.But in actual production, can take the circumstances into consideration increase dosage or extend the period for the treatment of according to the concrete state of an illness.
In sum, anti-exhaling rather has good therapeutic effect to chicken chronic respiratory tract disease, and cure rate reaches 91.6%, higher than contrast, and application is anti-exhales peaceful the relative weight gain 126%, and therefore, said preparation has wide application value clinically.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (6)
1. for preventing and treating a medicine for fowl respiratory tract infection, it is characterized in that: comprise following component:
Ribavirin 0.1-1g,
Aspirin sodium 0.25-2.5g,
Mequindox 0.1g-1g,
Sodium carboxymethyl cellulose 0.25-2.5g,
Propylene glycol 0.5-5ml,
Tween-80 0.5-5ml。
2. the medicine for preventing and treating fowl respiratory tract infection according to claim 1, is characterized in that: comprise following component:
Ribavirin 0.5g,
Aspirin sodium 1.25g,
Mequindox 0.5g,
Sodium carboxymethyl cellulose 1.25g,
Propylene glycol 2.5ml,
Tween-80 2.5ml。
3. according to claim 1 or 2, treat the process for preparing medicine of fowl respiratory tract infection, it is characterized in that: comprise the following steps:
1) first Mequindox, Aspirin sodium are added in 100ml deionized water, be heated to dissolve, obtain dosing 1, for subsequent use after placing room temperature;
2) ribavirin is added in 100ml deionized water, then add propylene glycol and Tween-80 respectively, stir, obtain dosing 2;
3) dosing 1 is joined in dosing 2, then add 0.25g sodium carboxymethyl cellulose, after adding deionized water to 1000ml, stir and obtain the medicine for the treatment of fowl respiratory tract infection.
4. the process for preparing medicine for the treatment of fowl according to claim 3 respiratory tract infection, it is characterized in that: in described step 1), heating 1 is little of 80 DEG C.
5. the process for preparing medicine for the treatment of fowl according to claim 3 respiratory tract infection, is characterized in that: described step 2) in, namely room temperature 200 revs/min of high-speed stirred obtain dosing 2 in 30 minutes.
6. the process for preparing medicine for the treatment of fowl according to claim 3 respiratory tract infection, is characterized in that: in described step 3), room temperature 200 revs/min of high-speed stirred 10 minutes.
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Cited By (1)
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| CN105232763A (en) * | 2015-10-19 | 2016-01-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine combination for treating avian respiratory tract infection and preparation method and application thereof |
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| CN101947201A (en) * | 2010-09-08 | 2011-01-19 | 洛阳惠中兽药有限公司 | Veterinary nanometer suspension, preparation method thereof and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105232763A (en) * | 2015-10-19 | 2016-01-13 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine combination for treating avian respiratory tract infection and preparation method and application thereof |
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