CN104585185B - A kind of bactericidal composition containing cyprodinil and fluoxastrobin and application thereof - Google Patents
A kind of bactericidal composition containing cyprodinil and fluoxastrobin and application thereof Download PDFInfo
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- CN104585185B CN104585185B CN201510057362.9A CN201510057362A CN104585185B CN 104585185 B CN104585185 B CN 104585185B CN 201510057362 A CN201510057362 A CN 201510057362A CN 104585185 B CN104585185 B CN 104585185B
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Abstract
The present invention relates to a kind of bactericidal composition containing cyprodinil and fluoxastrobin and application thereof.Described compositions contains cyprodinil and fluoxastrobin, and the weight ratio of described cyprodinil and fluoxastrobin is 1-40:1-40.Said composition can be applicable to the preventing and treating of control economic disease of pests evil.Said composition is applied widely, effective, cost is low, it is low to remain, safe for human, animal and environment.
Description
Technical field
The present invention relates to a kind of bactericidal composition and purposes, particularly relate to a kind of bactericidal composition containing cyprodinil and fluoxastrobin and application thereof, be mainly used in the preventing and treating of industrial crops disease.
Background technology
Cyprodinil (Cyprodinil; CAS 121552-61-2) it is a kind of methionine biosynthesis inhibitor; the no interactions resistances such as same triazole type, imidazoles, morpholine class, phenylpyrrole class, have protection, treatment, blade penetrate and root systemic activity.Foliar spray or seed treatment, it is possible to do Fructus Hordei Vulgaris seed coat agent medication.
Fluoxastrobin (Fluoxastrobin, CAS 193740-76-0) is methoxy acrylic bactericide, and the mechanism of action is mitochondrial respiratory inhibitor, namely by cytochrome b and C1Between electron transfer suppress mitochondrial breathing.The antibacterial acting on mitochondrial respiratory is more, but the position of methoxy acrylic ester compounds effect (cytochrome b) is all different from conventional all antibacterial, therefore preventing and treating sterol inhibitor (sterolinhibitors), phenylamide (phenylamides), dicarboxylic dihydrazides amine (dicarboximides) and benzimidazole (benzimidazoles), the bacterial strain producing resistance is effective.
Fluoxastrobin application optimum period, is wide, no matter such as spore germination, germ tube growth and invades leaf portion in fungal infection early stage, or can provide extraordinary protection and therapeutical effect at growth period of hypha；But spore germination and initial stage are infected most effective.Because of the excellent systemic activity having, it can be rapidly absorbed, and can transmit to top equably in leaf portion, therefore has the resistance of rainwater washing against ability that root is good.
Although fluoxastrobin has above-mentioned advantage, but owing to cost is too high, domestic almost without application at present.Cyprodinil is more and more on preventing and treating vegetable disease in the last few years, and majority be single dose, and the easy Drug resistance of life-time service, lasting period shortening, dose such as increase at problem, the residual increased risk, are unfavorable for environment harmonious development.Seek scientific and rational agriculture chemical compounding, be solve the good way of this problem.At present at home and abroad there are no the relevant report that cyprodinil and fluoxastrobin are composite.If both energy are composite together, it becomes possible to solve above-mentioned produced problem preferably, compare single dose after composite both simultaneously and there is synergistic function, the effect that raising single dose is used alone.At present at home and abroad but without the relevant report that cyprodinil and fluoxastrobin are composite.
Summary of the invention
An object of the present invention is in that to overcome above-mentioned deficiency, it is provided that a kind of applied widely, effective, remain little, consumption is low, cost is low, lasting period length and have the bactericidal composition containing cyprodinil and fluoxastrobin of potentiation.
The two of the purpose of the present invention are in that the purposes providing a kind of bactericidal composition containing cyprodinil and fluoxastrobin for control economic disease of pests evil.
The object of the present invention is achieved like this:
A kind of bactericidal composition containing cyprodinil and fluoxastrobin, the active component contained by described compositions includes cyprodinil and fluoxastrobin, and the weight ratio of described cyprodinil and fluoxastrobin is 1-40:1-40.
The preferred weight ratio of described cyprodinil and fluoxastrobin is 3-30:5-30；
It is highly preferred that the weight ratio of the two is 1-10:1-10；
Most preferred, the weight ratio of the two is 1:1.
Described combination dosage form is any one dosage form allowed on pesticide.Such as wettable powder, water dispersible granules, suspending agent, aqueous emulsion, cream or seed coat agent etc..
The weight of described cyprodinil and fluoxastrobin and the percentage by weight in above-mentioned dosage form are 5～80%.
Further, the present invention provides a kind of purposes containing cyprodinil and the bactericidal composition of fluoxastrobin as above, by described Bactericidal composite for being used for control economic disease of pests evil；Preferably, described disease is: tomato late blight, early blight, watermelon grafting, droop, Camellia sinensis gall of tea, bud blight, downy mildew of garpe, gray mold, white rot, anthrachose of grape, vegetable downy mildew, clubroot, canker, tobacco downy mildew, balck shank, damping off, pear scab, ring spot, melasma, scab of apple, ring spot, spot defoliation, canker, citrus anthracnose, shot hole, blossom-end rot, capsicum epidemic disease, leaf spot of peanut, damping-off, southern blight, sclerotinia rot of colza, the late blight of potato, cotton seedling blight, corn northern and southern leaf blight, coffee rust, brown spot, mango anthracnose, blossom-end rot, sigatoka, scab, anthrax, bunchy top, sheath maize ear rot, Prospect on Kiwifruit Bacterial Canker etc..It is preferred for the preventing and treating of citrus scab, tea tree germ rot, mango anthracnose, canker of apple fruit or grapevine anthracnose.
Compared with prior art, the invention has the beneficial effects as follows:
(1) potentiation that the present composition is done well in certain ratio range, the bactericidal effect of compositions is obviously improved than single dose, and its co-toxicity coefficient is at least more than 120, reduces Pesticide use dosage and cost simultaneously, decrease residual, also mitigate the harmful effect to environment；
(2) in the present invention, the mechanism of action of two kinds of active component is different, and the application of compositions can delay or overcome the resistance of pathogen, extends the service life of product；
(3) present composition is excellent to industrial crops disease preventive effect, additionally, can also be used for the preventing and treating of its corps diseases.
Detailed description of the invention
In order to be that the purpose of the present invention, technical scheme and advantage are clearly understood, the present invention illustrates with following instantiation, but the present invention is not limited to these examples.
The present composition, with cyprodinil and fluoxastrobin for effective ingredient, finds through indoor bioassay test, and after both are composite, antagonistic drug sexually transmitted disease (STD)s evil has obvious synergistic function, is specifically illustrated with following bioassay example.
Mensuration example 1 in kind: cyprodinil and the composite toxicity test to citrus scab bacterium of fluoxastrobin
1, subjects: Citrus citrus scab bacterium [Classification system: Elsinoefewcetti]
2, test method: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", adopts pastille medium therapy.
3, data statistic analysis: be analyzed with SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC50And co-toxicity coefficient.
4, evaluation methodology: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", co-toxicity coefficient method (CTC) according to SunJohnson (1960) evaluates the potentiation of pharmacy mix, namely CTC≤80 are antagonism, 80<CTC<120 is summation action, and CTC>=120 are potentiation.
5, result and analysis
The mixture of cyprodinil, fluoxastrobin and the two different proportion thereof combines the toxicity test result to citrus scab bacterium in Table 1, and in table 1, " phonetic: fluorine " is writing a Chinese character in simplified form of " cyprodinil: fluoxastrobin ".
Table 1 cyprodinil and the fluoxastrobin mixture toxicity test result to citrus scab bacterium
Indoor biometrics result shows: cyprodinil and fluoxastrobin carry out mixture with 1: 9,1: 5,1: 3,1: 1,3: 1,5: 1 and 9: 1 ratios, citrus scab bacterium is all shown potentiation by it, and wherein the ratio mixed synergies with 1: 5,1: 3,1: 1 and 3: 1 is the most obvious.Consider cyprodinil with fluoxastrobin, the preventing and treating of citrus scab is composite better with 1:5～3:1.
Mensuration example 2 in kind: cyprodinil and the composite toxicity test to tea tree germ rot bacterium of fluoxastrobin
1, subjects: tea tree germ rot bacterium [Classification system: Gibberellabaccata]
2, test method: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", adopts pastille medium therapy.
3, data statistic analysis: be analyzed with SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC50And co-toxicity coefficient.
4, evaluation methodology: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", co-toxicity coefficient method (CTC) according to Sun&Johnson (1960) evaluates the potentiation of pharmacy mix, namely CTC≤80 are antagonism, 80<CTC<120 is summation action, and CTC>=120 are potentiation.
5, result and analysis
The mixture of cyprodinil, fluoxastrobin and the two different proportion thereof combines the toxicity test result to tea tree germ rot bacterium in Table 2, and in table 2, " phonetic: fluorine " is writing a Chinese character in simplified form of " cyprodinil: fluoxastrobin ".
Table 2 cyprodinil and the fluoxastrobin mixture toxicity test result to tea tree germ rot bacterium
Indoor biometrics result shows: cyprodinil and fluoxastrobin carry out mixture with 1: 9,1: 5,1: 3,1: 1,3: 1,5: 1 and 9: 1 ratios, tea tree germ rot bacterium is all shown potentiation by it, wherein with 1: 5,1: 3,1:1,3:1,5:1 and 9: the ratio mixed synergies of 1 is the most obvious.Consider cyprodinil with fluoxastrobin, the preventing and treating of tea tree germ rot is composite better with 1:5～9:1.
Mensuration example 3 in kind: cyprodinil and the composite toxicity test to Colletotrichum gloeosporioides Penz in Mango of fluoxastrobin
1, subjects: Colletotrichum gloeosporioides Penz in Mango [Classification system: Colletotrichumgloeosporioiles]
2, test method: with reference to " farm-chemical indoor determination test rule NY/T1156.12-2008 ", adopts pastille medium therapy.
3, data statistic analysis: be analyzed with SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC50And co-toxicity coefficient.
4, evaluation methodology: with reference to " farm-chemical indoor determination test rule NY/T1156.12-2008 ", co-toxicity coefficient method (CTC) according to Sun&Johnson (1960) evaluates the potentiation of pharmacy mix, namely CTC≤80 are antagonism, 80<CTC<120 is summation action, and CTC>=120 are potentiation.
5, result and analysis
The mixture of cyprodinil, fluoxastrobin and the two different proportion thereof combines the toxicity test result to Colletotrichum gloeosporioides Penz in Mango in Table 3, and in table 3, " phonetic: fluorine " is writing a Chinese character in simplified form of " cyprodinil: fluoxastrobin ".
Table 3 cyprodinil and the fluoxastrobin mixture toxicity test result to Colletotrichum gloeosporioides Penz in Mango
Indoor biometrics result shows: cyprodinil and fluoxastrobin carry out mixture with 1: 12,1: 9,1: 6,1: 1,6: 1,9: 1 and 12: 1 ratios, Colletotrichum gloeosporioides Penz in Mango is shown potentiation by it, wherein with 1: 9,1: 6,1:1,6:1 and 9:1 ratio mixed synergies the most obvious.Consider cyprodinil with fluoxastrobin, the preventing and treating that mango anthracnose is sick is composite better with 1:9～9:1.
Mensuration example 4 in kind: cyprodinil and the composite toxicity test to Valsa mali of fluoxastrobin
1, subjects: Valsa mali [Classification system: CytosporamandshuricaMiura]
2, test method: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", adopts pastille medium therapy.
3, data statistic analysis: be analyzed with SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC50And co-toxicity coefficient.
4, evaluation methodology: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", co-toxicity coefficient method (CTC) according to Sun&Johnson (1960) evaluates the potentiation of pharmacy mix, namely CTC≤80 are antagonism, 80<CTC<120 is summation action, and CTC>=120 are potentiation.
5, result and analysis
The mixture of cyprodinil, fluoxastrobin and the two different proportion thereof combines the toxicity test result to Valsa mali in Table 4, and in table 4, " phonetic: fluorine " is writing a Chinese character in simplified form of " cyprodinil: fluoxastrobin ".
Table 4 cyprodinil and the fluoxastrobin mixture toxicity test result to Valsa mali
Indoor biometrics result shows: cyprodinil and fluoxastrobin carry out mixture with 1: 10,1: 5,1: 1,1: 1,3: 1,5: 1 and 10: 1 ratios, Valsa mali is shown potentiation by it, wherein with 1: 10,1: 5,1:3,1:1,3:1 and 5: the ratio mixed synergies of 1 is the most obvious.Consider cyprodinil with fluoxastrobin, the preventing and treating that canker of apple fruit is sick is composite better with 1-5:1-10.
Mensuration example 5 in kind: cyprodinil and the composite toxicity test to Elsinǒe ampelina of fluoxastrobin
1, subjects: Elsinǒe ampelina [Classification system: Sphacelomaampelinum]
2, test method: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", adopts pastille medium therapy.
3, data statistic analysis: be analyzed with SAS6.12 statistical software.Calculate mycelial growth inhibition rate (%) according to test data, obtain virulence regression equation formula, correlation coefficient (r), EC50And co-toxicity coefficient.
4, evaluation methodology: with reference to " farm-chemical indoor determination test rule NY/T1156.2-2006 ", co-toxicity coefficient method (CTC) according to Sun&Johnson (1960) evaluates the potentiation of pharmacy mix, namely CTC≤80 are antagonism, 80<CTC<120 is summation action, and CTC>=120 are potentiation.
5, result and analysis
The mixture of cyprodinil, fluoxastrobin and the two different proportion thereof combines the toxicity test result to Elsinǒe ampelina in Table 5, and in table 5, " phonetic: fluorine " is writing a Chinese character in simplified form of " cyprodinil: fluoxastrobin ".
Table 5 cyprodinil and the fluoxastrobin mixture toxicity test result to Elsinǒe ampelina
Indoor biometrics result shows: cyprodinil and fluoxastrobin carry out mixture with 1: 20,1: 10,1: 5,1: 1,5: 1,10: 1 and 20: 1 ratios, Elsinǒe ampelina is shown phase additive synergism by it, and wherein the ratio mixed synergies with 5:1 is the most obvious.Consider cyprodinil with fluoxastrobin, the preventing and treating of grapevine anthracnose is composite better with 5:1.
The present composition can with known auxiliary agent and adjuvant, with known method preparation in being suitable for any one dosage form of agriculturally using, wherein reasonable dosage form has water dispersible granules, suspending agent, aqueous emulsion, cream or seed coat agent, and these known auxiliary agents, adjuvant have dispersant, diffusant, defoamer, wetting agent, disintegrating agent, film former and filler etc..
Illustrate with instantiation below.
Embodiment 1:
Cyprodinil 10g, fluoxastrobin 15g, Ketohexamethylene 15g, Oleum Terebinthinae are added to 100g, and mixing, to homogeneous liquid phase, prepares cream.
Embodiment 2:
Cyprodinil 15g, fluoxastrobin 15g, NPE 8g, sodium lauryl sulphate 6g, Magnesiumaluminumsilicate 1g, kieselguhr adds to 100g, and blended, superfine grinding, pelletize prepare water dispersible granules.
Embodiment 3:
By cyprodinil 20g, fluoxastrobin 5g, polyoxyethylene carboxylate 5g, alkylphenol polyoxyethylene 6g, xanthan gum 0.5g, propylene glycol 2g, organosilicon 0.5g, add water to 100g, mix through wet grinding, homogenizing, prepare suspending agent.
Embodiment 4:
Cyprodinil 20g, fluoxastrobin 50g, sodium lignin sulfonate 8g, sodium lauryl sulphate 5g, white carbon 10g, bentonite are added to 100g, mixes and prepare wettable powder through comminution by gas stream.
Embodiment 5:
By cyprodinil 10g, fluoxastrobin 5g, Oleum Terebinthinae 6g, NPE 10g, alkylphenol polyoxyethylene phosphate ester 1g, polyvinyl alcohol 2g, xanthan gum 0.1g, add water to 100g, preparation oil phase, preparation aqueous phase, under high shear, in oil phase aqueous phase or aqueous phase is added in oil phase, will shear and prepare aqueous emulsion.
Embodiment 6:
By cyprodinil 2.5g, fluoxastrobin 7.5g, polyoxyethylene carboxylate 6g, NPE 5g, Magnesiumaluminumsilicate 1g, polyvinyl alcohol 2g, organosilicon 0.5g, ethylene glycol 2g, basic rhodamine 0.5g, add water to 100g, mix through wet grinding, homogenizing, prepare suspension seed-coating agent.
A kind of bactericidal composition containing cyprodinil and fluoxastrobin of the present invention is described already by concrete example, those skilled in the art can use for reference present invention, the links such as suitable feed change, process conditions realize other purpose corresponding, its relevant change is all without departing from present disclosure, all similar replacements and change will become apparent to those skilled in the art that and be considered as being included within the scope of the present invention.
Claims (2)
1. the bactericidal composition containing cyprodinil and fluoxastrobin prevents and treats the application in tea tree germ rot medicine in preparation, it is characterised in that the mass ratio of cyprodinil and fluoxastrobin is 1:3,1:5, or 1:9.
2. application according to claim 1, it is characterised in that the dosage form of compositions is wettable powder, water dispersible granules, suspending agent, aqueous emulsion, cream or seed coat agent.
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| CN101647454A (en) * | 2009-06-26 | 2010-02-17 | 深圳诺普信农化股份有限公司 | Sterilizing composition containing cyprodinil |
| CN101755758B (en) * | 2009-10-26 | 2013-03-13 | 陕西汤普森生物科技有限公司 | Fungicidal composition containing kresoxim methyl and cyprodinil |
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