CN104548009A - Traditional Chinese medicine composition for enhancing immunity as well as preparation method and application of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for enhancing immunity as well as preparation method and application of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for enhancing immunity as well as a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw material components in parts by weight: 1-5 parts of codonopsis pilosula, 1-5 parts of astragalus, 1-5 parts of bighead atractylodes rhizome, 1-5 parts of white paeony root, 1-5 parts of jujube, 1-5 parts of dried ginger and 2-6 parts of radix glycyrrhizae. The traditional Chinese medicine composition adopts natural traditional Chinese medicine raw material components, is simple and convenient to prepare, wide in medicine source, remarkable in effect of enhancing immunity and free of toxic or side effect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of enhancing immunity, preparation method and application.
Background technology
Immune system (immune system) is the defensive structure of body protective self; primarily of lymphatic organ (thymus, lymph node, spleen, tonsil) and the composition such as other intraorganic lymphoid tissues and whole body lymphocyte everywhere, antigen-presenting cell, they are the most effective weapons of body defence pathogen invasion.Immunity is the self-defensive system that human body is used for identifying and the foreign body such as defend against computer virus, antibacterial is encroached on.The reason of hypoimmunity is caused to have a lot, the immunity as bad in environment, the human body is tired, diet is unbalance, hypomotility, excessively antibacterial, body ages etc. all can reduce human body.Hypoimmunity can cause the generation of various disease; the often ill consumption increasing the weight of body; generally have a delicate constitution, the reduction of malnutrition, lethargy, fatigue and weak, appetite, the performance such as sleep disorder; supplemented the nutrients by usual channel plain, balanced diet contributes to improving immunity of organisms.
The traditional Chinese medical science thinks that the factor such as the generation of immunological diseases and main, the diseases caused by exogenous pathogenic factor six climate exopathogens not enough with natural endowment of development evil, the four stages in the course of an epidemic febrile disease lack of proper care, function disorderly, the interior life of the turbid congestion of expectorant is closely related.Principle of mainly curing the disease is that righting is got rid of evils, and righting refers to helps body healthy energy, health invigorating, improves the anti-evil resistance against diseases of body, the enhancing immunity that its Therapeutic Principle and Immunology Today are said, it is consistent for improving body disease resistance ability.
The prescription that prior art provides is not good enough for the combined therapy effect of hypoimmunity, and to warming and recuperating the spleen and kidney, Yiyang cold relieving is that the dialectical composition of prescription of the rule for the treatment of there is no report.
Summary of the invention
The first object of the present invention is the Chinese medicine composition providing a kind of enhancing immunity, and the pathogeny for hypoimmunity carries out the dialectical compatibility of prescription, plays warming and recuperating the spleen and kidney, and the effect of Yiyang cold relieving, may be used for immunocompromised person.
The Chinese medicine composition of enhancing immunity of the present invention, the raw material of described Chinese medicine composition comprises following component by weight: Radix Codonopsis 1 ~ 5 part, the Radix Astragali 1 ~ 5 part, the Rhizoma Atractylodis Macrocephalae 1 ~ 5 part, the Radix Paeoniae Alba 1 ~ 5 part, 1 ~ 5 part, Fructus Jujubae, Rhizoma Zingiberis 1 ~ 5 part, 2 ~ 6 parts, Radix Glycyrrhizae.
As preferably scheme, the raw material of described Chinese medicine composition comprises following component by weight: Radix Codonopsis 3 parts, the Radix Astragali 3 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, the Radix Paeoniae Alba 3 parts, 3 parts, Fructus Jujubae, Rhizoma Zingiberis 3 parts, 4 parts, Radix Glycyrrhizae.
Further, the raw material of described Chinese medicine composition also comprises adjuvant 0 ~ 10 part, is preferably 7 parts.
Chinese medicine composition of the present invention can be prepared into the regular dosage form of field of medicaments, as decoction, powder agent, tablet, capsule, syrup etc.
Described adjuvant is selected from one or more in maltodextrin, lactose, glucose, microcrystalline Cellulose, methylcellulose, sodium carboxymethyl cellulose, magnesium stearate, silicon dioxide, Pulvis Talci, Polyethylene Glycol or starch.
Compositions of the present invention is preferably powder agent, and this formulation method is simple and be easy to patient and take, and described adjuvant is preferably maltodextrin.
The Chinese medicine composition of enhancing immunity of the present invention is powder agent, and the raw material of described Chinese medicine composition comprises following component by weight: Radix Codonopsis 1 ~ 5 part, the Radix Astragali 1 ~ 5 part, the Rhizoma Atractylodis Macrocephalae 1 ~ 5 part, the Radix Paeoniae Alba 1 ~ 5 part, 1 ~ 5 part, Fructus Jujubae, Rhizoma Zingiberis 1 ~ 5 part, 2 ~ 6 parts, Radix Glycyrrhizae, maltodextrin 0 ~ 10 part.
As preferably scheme, the raw material of described Chinese medicine composition comprises following component by weight: Radix Codonopsis 3 parts, the Radix Astragali 3 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, the Radix Paeoniae Alba 3 parts, 3 parts, Fructus Jujubae, Rhizoma Zingiberis 3 parts, 4 parts, Radix Glycyrrhizae, maltodextrin 7 parts.
Weight portion of the present invention can be μm, the known unit of weight of field of medicaments such as mg, g, kg, also can be its multiple, as 1/10,1/100,10 times, 100 times etc.
When Chinese medicine composition of the present invention is decoction, directly can takes medical material and conventionally decoct and form.The compositions of other dosage form is conventionally processed by interpolation adjuvant and is prepared from, and preferably adopts following preparation method.
Another object of the present invention is to provide the preparation method of described Chinese medicine composition, comprises the following steps:
(1) get Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, after pulverizing, mixing, adds the water of 8 ~ 12 times of volumes, soaks 20 ~ 40min, and decoct 100 ~ 150min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add the water of 6 ~ 10 times of volumes again, decoct 40 ~ 80min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, described extractum, to obtaining the extractum that relative density is 1.0 ~ 1.5, is spray dried to powder and namely obtains described Chinese medicine composition by concentrated filtrate; Or adjuvant is added in described extractum, described extractum is spray dried to powder and namely obtains described Chinese medicine composition; Or more state extractum and be prepared into various dosage form according to a conventional method.
As preferably scheme, the preparation method of described Chinese medicine composition, comprises the following steps:
(1) get Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, after pulverizing, mixing, adds the water of 10 times of volumes, soaks 30min, and decoct 120min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add the water of 8 times of volumes again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, described extractum, to obtaining the extractum that relative density is 1.2, is spray dried to powder and namely obtains described Chinese medicine composition by concentrated filtrate; Or adjuvant is added in described extractum, described extractum is spray dried to powder and namely obtains described Chinese medicine composition.
The present invention also provides the application of described Chinese medicine composition in preparation treatment hypoimmunity medicine.
Chinese medicine composition provided by the invention, has warming and recuperating the spleen and kidney, the effect of Yiyang cold relieving, and all medical materials play drug effect jointly according to the principle of monarch.
Concrete, Radix Codonopsis, the Radix Astragali are sweet in flavor and warm in property, air making-up and spleen enlivening, and can the gas of spleen reinforcing lung greatly in the Radix Astragali, outward can strengthening superficial resistance to stop perspiration.Spleen is wet soil, yang deficiency then easy raw cold-damp, therefore with the dry Rhizoma Atractylodis Macrocephalae of sweet temperature hardship, the spleen strengthening and damp drying, warming and recuperating the spleen and kidney.The Rhizoma Atractylodis Macrocephalae, bitter in the mouth, sweet, warm in nature, there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Radix Paeoniae Alba harmonizing yingfen and weifen, tonifying YIN holds back battalion, and battalion defends rules together, fluent the exterior and the interior.Rhizoma Zingiberis, Fructus Jujubae warming the stomach grow spleen, and the strong then diet of taste enters more, and body constitution is strong, and it is congenital to help also can to support the day after tomorrow.With Radix Glycyrrhizae Preparata coordinating the actions of various ingredients in a prescription.The party's warming YANG is main, helps with tonifying YIN, mends and not strong, recuperates under medical treatment lastingly, interior can warming and recuperating the spleen and kidney, solid protection can defend gas outward, inside and outside take into account, be applicable to weak, the crowd such as be afraid of cold.
Modern pharmacological research shows, the effective ingredient in Radix Codonopsis, has immunocompetence, can improve immunity of organisms.Astragalus polysaccharides in the Radix Astragali, all has obvious potentiation to the cellular immunization of normal mouse, humoral immunization and macrophage function.Rhizoma Atractylodis polysaccharide is the active ingredient of Chinese herbs that the Rhizoma Atractylodis Macrocephalae plays immunologic enhancement, has obvious immunological enhancement.Jujube polysaccharide can significantly improve peritoneal macrophage phagocytic percentage and the phagocytic index of immunosuppressed mice, has the effect improving immunologic function.Angelica Polysaccharide significantly can promote the lymphocytic propagation of body T, has obvious potentiation to the immunity of body, also can strengthen humoral immune function simultaneously.
The component of Chinese medicine composition of the present invention all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source wide, improves immunity Be very effective, and has no side effect.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.If do not specialize, the conventional means that technological means used in embodiment is well known to those skilled in the art, is raw materials usedly commercial goods (as Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae etc.).
Embodiment 1:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity: Radix Codonopsis 3g, Radix Astragali 3g, Rhizoma Atractylodis Macrocephalae 3g, Radix Paeoniae Alba 3g, Fructus Jujubae 3g, Rhizoma Zingiberis 3g, Radix Glycyrrhizae 4g, maltodextrin 7g.
2, Chinese medicine composition preparation method described in the present embodiment, comprises following steps:
(1) by with measuring Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, mixing, add 248ml water after pulverizing, soak 30min, decoct 120min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add 186ml water again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, concentrated filtrate is to relative density 1.2, and add maltodextrin, spraying dry obtains powder, obtains described Chinese medicine composition powder agent.
Embodiment 2:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity: Radix Codonopsis 3g, Radix Astragali 3g, Rhizoma Atractylodis Macrocephalae 3g, Radix Paeoniae Alba 3g, Fructus Jujubae 3g, Rhizoma Zingiberis 3g, Radix Glycyrrhizae 4g, maltodextrin 7g.
2, Chinese medicine composition preparation method described in the present embodiment, compared with embodiment 1, difference is only, it is 200ml that step (1) adds the water yield, and it is 140ml that step (2) adds the water yield.
Embodiment 3:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity: Radix Codonopsis 3g, Radix Astragali 3g, Rhizoma Atractylodis Macrocephalae 3g, Radix Paeoniae Alba 3g, Fructus Jujubae 3g, Rhizoma Zingiberis 3g, Radix Glycyrrhizae 4g, maltodextrin 7g.
2, Chinese medicine composition preparation method described in the present embodiment, compared with embodiment 1, difference is only, it is 260ml that step (1) adds the water yield, and it is 160ml that step (2) adds the water yield.
Embodiment 4:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity with embodiment 1.
2, Chinese medicine composition preparation method described in the present embodiment, comprises following steps:
(1) by with measuring Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, mixing, add 310ml water after pulverizing, soak 40min, decoct 100min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add 248ml water again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, concentrated filtrate is to relative density 1.0, and add maltodextrin, spraying dry obtains powder, obtains described Chinese medicine composition powder agent.
Embodiment 5:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity with embodiment 1.
2, Chinese medicine composition preparation method described in the present embodiment, comprises following steps:
(1) by with measuring Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, mixing, add 279ml water after pulverizing, soak 20min, decoct 150min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add 217ml water again, decoct 40min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, concentrated filtrate is to relative density 1.5, and add maltodextrin, spraying dry obtains powder, must organize described Chinese medicine composition powder agent.
Embodiment 6:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity with embodiment 1.
2, Chinese medicine composition preparation method described in the present embodiment, comprises following steps:
(1) by with measuring Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, mixing, add 310ml water after pulverizing, soak 30min, decoct 120min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add 248ml water again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, concentrated filtrate is to relative density 1.0, and add maltodextrin, spraying dry obtains powder, obtains described Chinese medicine composition.
Embodiment 7:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity: Radix Codonopsis 1g, Radix Astragali 1g, Rhizoma Atractylodis Macrocephalae 1g, Radix Paeoniae Alba 1g, Fructus Jujubae 1g, Rhizoma Zingiberis 1g, Radix Glycyrrhizae 2g, maltodextrin 1g.
2, Chinese medicine composition preparation method described in the present embodiment, comprises following steps:
(1) by with measuring Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, mixing, add 90ml water after pulverizing, soak 30min, decoct 120min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add 72ml water again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, concentrated filtrate is to relative density 1.0, and add maltodextrin, spraying dry obtains powder, obtains described Chinese medicine composition powder agent.
Embodiment 8:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity: Radix Codonopsis 5g, Radix Astragali 5g, Rhizoma Atractylodis Macrocephalae 5g, Radix Paeoniae Alba 5g, Fructus Jujubae 5g, Rhizoma Zingiberis 5g, Radix Glycyrrhizae 5g, maltodextrin 10g.
2, Chinese medicine composition preparation method described in the present embodiment, comprises following steps:
(1) by with measuring Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, mixing, add 450ml water after pulverizing, soak 30min, decoct 120min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add 360ml water again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, concentrated filtrate is to relative density 1.0, and add maltodextrin, spraying dry obtains powder, obtains described Chinese medicine composition powder agent.
Embodiment 9:
1, the present embodiment increases the traditional Chinese medicine composite composition of described strong immunity: Radix Codonopsis 5g, Radix Astragali 5g, Rhizoma Atractylodis Macrocephalae 5g, Radix Paeoniae Alba 5g, Fructus Jujubae 5g, Rhizoma Zingiberis 5g, Radix Glycyrrhizae 5g.
2, Chinese medicine composition preparation method described in the present embodiment, comprises following steps:
(1) by with measuring Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, mixing, add 450ml water after pulverizing, soak 30min, decoct 120min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add 360ml water again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, concentrated filtrate is to relative density 1.0, and spraying dry obtains powder, obtains described Chinese medicine composition powder agent.
Embodiment 10:
Compared with embodiment 1, distinctive points is only, the adjuvant of the present embodiment is magnesium stearate and microcrystalline Cellulose, is conventionally prepared into tablet.
Embodiment 11:
Compared with embodiment 1, distinctive points is only: the adjuvant of the present embodiment is Polyethylene Glycol and lactose, is conventionally prepared into capsule.
For verifying the effect of above-mentioned composition, the present invention expands a large amount of special test further, and length limit, and only exemplifies the test example of part most cogency herein.
Experimental example 1: the test of pesticide effectiveness improving the Chinese medicine composition of immunity
1 experimental project
The inbred mouse of 1.1 mices: BALB/C bis-monthly age 18-22g male and female half and half, often organizes 10.
1.2 feeding methods: respectively with low power (50mg/kgbw), in doubly (100mg/kgbw), high power (200mg/kgbw) are fed, take administration by gavage, once a day, give tested material continuously after 30 days, measure indices, separately establish two matched groups, one group gives deionized water (abbreviation control group A), and another group gives CN201110112977.9 example of formulations (being called for short matched group B).
1.3 cellular immune function assays: delayed allergy is tested, with reference to correlation technique in health product enhancing immunity function evaluation methods (2012 exposure draft).
1.4 humoral immune functions measure: antibody-producting cell detects, and serum hemolysin measures, with reference to correlation technique in health product enhancing immunity function evaluation methods (2012 exposure draft).
1.5 monokaryons-macrophage function measures: Turnover of Mouse Peritoneal Macrophages engulfs fluorescent microsphere experiment, with reference to correlation technique in health product enhancing immunity function evaluation methods (2012 exposure draft).
2 experimental results
2.1 delayed hypersensitivitys (the sufficient sole of the foot thickens method) result
Table 1: on the impact (swelling degree of the paw difference mm) of mice delayed hypersensitivity
In this test, toes swelling difference is the difference of toes thickness before and after attacking.Known according to table 1, the toes swelling difference of embodiment of the present invention group is all higher than matched group.Compare with matched group, all there were significant differences for each embodiment group swelling degree of the paw, namely the foot of embodiment group sample on mice opens up swelling impact significantly, and illustrate that tested material has appreciable impact to mice delayed hypersensitivity, the sample of embodiment group can strengthen the delayed allergy of mice.
2.2 antibody-producting cell testing results
Table 2: on the impact (individual) of mouse antibodies cellulation
This test determination hemolysis plaque number of each embodiment group and matched group.Known according to table 2, compare with matched group, the antibody-producting cell breeding of sample to mice of each embodiment group has facilitation, and the antibody-producting cell of each embodiment group is improved, and especially, dosage group has appreciable impact to mouse antibodies cellulation.
The measurement result of 2.3 serum hemolysins
Table 3: on the impact (HC50) of serum hemolysin
Known according to table 3, compare with matched group, each enforcement group sample dose group has pole significant difference, illustrates that implementing sample can improve mice serum hemolysin HC50 in pole significantly.
2.4 Turnover of Mouse Peritoneal Macrophages engulf chicken red blood cell experimental result
Table 4: on the impact (%) of mouse macrophage phagocytic rate
Known according to table 4, compare with matched group, the abdominal cavity macrophage phagocytosis of each enforcement group sample dose group has pole significant difference, and illustrating that the routine sample of enforcement group is high can improve the phagocytic rate of mouse macrophage in pole significantly.
3 experiment conclusion
According to the decision method improving immunity in correlation technique in health product enhancing immunity function evaluation methods (2012 exposure draft), can assert that each enforcement group sample all has the effect improving immunity, wherein the sample raising immune effect of embodiment 1 is more excellent.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (9)
1. the Chinese medicine composition of an enhancing immunity, it is characterized in that, the raw material of described Chinese medicine composition comprises following component by weight: Radix Codonopsis 1 ~ 5 part, the Radix Astragali 1 ~ 5 part, the Rhizoma Atractylodis Macrocephalae 1 ~ 5 part, the Radix Paeoniae Alba 1 ~ 5 part, 1 ~ 5 part, Fructus Jujubae, Rhizoma Zingiberis 1 ~ 5 part, 2 ~ 6 parts, Radix Glycyrrhizae.
2. Chinese medicine composition according to claim 1, is characterized in that, the raw material of described Chinese medicine composition comprises following component by weight: Radix Codonopsis 3 parts, the Radix Astragali 3 parts, the Rhizoma Atractylodis Macrocephalae 3 parts, the Radix Paeoniae Alba 3 parts, 3 parts, Fructus Jujubae, Rhizoma Zingiberis 3 parts, 4 parts, Radix Glycyrrhizae.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, the raw material of described Chinese medicine composition also comprises adjuvant 0 ~ 10 part, is preferably 7 parts.
4. Chinese medicine composition according to claim 3, it is characterized in that, described adjuvant is selected from one or more in maltodextrin, lactose, glucose, microcrystalline Cellulose, methylcellulose, sodium carboxymethyl cellulose, magnesium stearate, silicon dioxide, Pulvis Talci, Polyethylene Glycol or starch, is preferably maltodextrin.
5. Chinese medicine composition according to claim 4, is characterized in that, described Chinese medicine composition is decoction, powder agent, tablet, capsule or syrup.
6. Chinese medicine composition according to claim 5, is characterized in that, described Chinese medicine composition is powder agent, and the adjuvant of described powder agent is maltodextrin.
7. the preparation method of Chinese medicine composition according to any one of claim 1 to 6, is characterized in that, comprises the following steps:
(1) get Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, after pulverizing, mixing, adds the water of 8 ~ 12 times of volumes, soaks 20 ~ 40min, and decoct 100 ~ 150min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add the water of 6 ~ 10 times of volumes again, decoct 40 ~ 80min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, described extractum, to obtaining the extractum that relative density is 1.0 ~ 1.5, is spray dried to powder and namely obtains described Chinese medicine composition by concentrated filtrate; Or adjuvant is added in described extractum, described extractum is spray dried to powder and namely obtains described Chinese medicine composition.
8. the preparation method of Chinese medicine composition according to claim 7, is characterized in that, comprise the following steps:
(1) get Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Fructus Jujubae, Rhizoma Zingiberis, Radix Glycyrrhizae, after pulverizing, mixing, adds the water of 10 times of volumes, soaks 30min, and decoct 120min, filtration under diminished pressure, filtrate is for subsequent use, retains medicinal residues;
(2) in step (1) gained medicinal residues, add the water of 8 times of volumes again, decoct 60min, filtration under diminished pressure, filtrate is for subsequent use;
(3) step (1) and step (2) gained filtrate are merged, cross 200 mesh sieves and 400 mesh sieves successively, described extractum, to obtaining the extractum that relative density is 1.2, is spray dried to powder and namely obtains described Chinese medicine composition by concentrated filtrate; Or adjuvant is added in described extractum, described extractum is spray dried to powder and namely obtains described Chinese medicine composition.
9. the application of Chinese medicine composition according to any one of claim 1 to 6 in preparation treatment hypoimmunity medicine.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106728272A (en) * | 2016-11-28 | 2017-05-31 | 曹礼静 | A kind of Chinese medicine composition for improving immunosuppressant animal immune level and its extract and application |
| CN111760002A (en) * | 2020-07-21 | 2020-10-13 | 刘仁海 | Traditional Chinese medicine for improving immunity and preparation method and application thereof |
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