CN103585539B - Traditional Chinese medicine composition for treating climacteric syndrome - Google Patents
Traditional Chinese medicine composition for treating climacteric syndrome Download PDFInfo
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Abstract
The invention discloses traditional Chinese medicine composition for treating the climacteric syndrome and relates to the technical field of traditional Chinese medicines. The composition is prepared from raw materials as follows: 8-20 parts of leonurus, 5-15 parts of ligusticum wallichii, 5-15 parts of white paeony roots, 3-10 parts of raspberries, 10-25 parts of bighead atractylodes rhizome, 5-15 parts of sealwort, 10-20 parts of bidentate achyranthes roots, 3-10 parts of rhizoma cyperi, 10-20 parts of spina date seeds, 5-15 parts of red-rooted salvia roots, 8-20 parts of poria cocos, 5-12 parts of prepared rehmannia roots, 10-20 parts of kudzu vine roots, 3-10 parts of fructus alpiniae oxyphyllae, 5-15 parts of polygala tenuifolia, 3-10 parts of light wheat, 3-10 parts of glossy privet fruits, 5-12 parts of herba epimedii, 10-15 parts of Chinese wolfberry fruits, 10-20 parts of dogwoods, 3-10 parts of saposhnikovia divaricata, 5-15 parts of schisandra chinensis, 5-15 parts of burdock, 5-25 parts of astragalus membranaceus and 10-20 parts of liquorice. Pharmacological experiments and clinical experiments prove that the traditional Chinese medicine composition is remarkable in effect of treatment of the climacteric syndrome.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition being used for the treatment of climacteric syndrome.
Background technology
Climacteric refers to that women is from the transition stage having reproductive performance to apogeny.This stage there is change in menstrual cycle characteristics in women, as polymenorrhea, hypomenorrhea, irregular menses and amenorrhea etc.Simultaneously, climacteric women causes the change of environment because of the change of Function of Ovary, have influence on the functional change of each tract and occur corresponding symptom, as hectic fever, perspiration, the unstable symptom of the vasomotoricities such as headache, the unstable symptom of the autonomic nervous functions such as cardiopalmus, dizzy, insomnia, paresthesia of skin, depression, anxiety, suspicious, self-confidence reduce, absent minded, emotional, feeling of terror even spirit, the mental symptoms such as hysterical attack sample symptom, are namely called climacteric syndrome.
Cause the reason of menopause syndrome be exactly ovarian function degeneration---climacteric change is the earliest ovarian failure, then just shows as the disorder of various hormone, cause involutional various change.No matter climacteric starts the morning and evening, how long lasts, and always can be divided into premenopause, menopause (ischomenia) and postmenopause (ischomenia is after 1 year), and with the decline gradually of ovarian function to disappearing completely for mark.Climacteric is that women progresses into senile transition stage from period of sexual maturity (period of duration), is an important and physiological change especially significantly stage in human senility process.As a rule, postclimacteric women there will be following four large symptoms climacteric: 1, hectic fever is the symptom that climacteric women often meets with; 2, cardiopalmus, namely has palpitation, and is also climacteric one of modal symptom; 3, spirit, nervous symptoms performance are extremely; 4, sore waist and aching in the waist and the back is the osteoporotic early symptom of climacteric women.And climacteric series of symptoms puzzlement, had a strong impact on women physically and mentally healthy, its harm has: 1. vascular dysfunctions: paroxysm disease flushing and hectic fever, namely feels suddenly chest, cervical region, face heating, perspire, fear of cold, sometimes accompany cardiopalmus, uncomfortable in chest, breathe hard, the symptom such as dizzy; 2. spirit, nervous symptoms: climacteric women often have worry, depression, emotional, have a sleepless night, cry well, hypomnesis, absent-minded etc., being happy and angry uncertainly sometimes, similar phrenoplegia; 3. tumor is easily sent out: climacteric is age occurred frequently of kinds of tumor, common are hysteromyoma, cervical cancer, ovarian tumor etc.If find earlier, early treatment, can improve therapeutic effect and survival.
The many employings of doctor trained in Western medicine " Hormone Replacement Therapy " are treated, the Therapeutic Method of current doctor trained in Western medicine is the estrogen with synthetic, as diethylstilbestrol, nilestriol, ethinylestradiol etc. make replacement therapy, but the estrogen of these synthetic of life-time service, endometrium hyperplasia, metrorrhagia can be caused, even cause cervical cancer, breast carcinoma.These above-mentioned Therapeutic Method toxic and side effects are comparatively large, halted gradually in states such as America and Europes.And Chinese medicine, often can be difficult to Symptomatic medicine, and specific aim is not strong, therapeutic effect is general; Therefore find medicine that is safe, effective, complete treatment climacteric syndrome, be one of pendulum important topic in face of vast medical research worker.
Chinese medicine is the medical science applied characteristic of China, have accumulated abundant clinical experience by the treatment of method to climacteric syndrome of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Chinese medicine calls climacteric syndrome " pre-postmenstrual syndromes ", think its main pathogenesis for suffering from a deficiency of the kidney, imbalance of YIN and YANG, Therapeutic Principle should the kidney invigorating and essence nourishing, YIN and YANG balance regulating.Therefore Treated with Chinese Decoction or the Chinese and Western compound preparation based on Chinese medicine of adopting treats this disease more clinically, for medication of suffering from a deficiency of the kidney, the kidney invigorating and essence nourishing, kidney qi must be mended, equilibrium between yin and yang, thus illness must heal, and reaches the object for the treatment of both the principal and secondary aspects of a disease, and long-term taking safety is good, be therefore more and more subject to the favor of extensive patients.Climacteric syndrome, belong to the category such as the traditional Chinese medical science " Bulbus Lilii syndrome ", " hysteria ", " before and after menopause all diseases ", women seventy-seven kidney qi degradation, menses gradually exhausts, kidney imbalance between YIN and YANG, rushes conception vessel void and declines for the principle pathological mechanism of climacteric syndrome.Suffering from a deficiency of the kidney is the basis of falling ill, that involves that the five internal organs then can cause between internal organs is unbalance, function of liver and spleen imbalance is the condition of morbidity, the spleen being the foundation of acquired constitution, the kidney being the origin of congenital constitution, primary disease and liver spleen kidney have close relationship, therefore the many coldheat complex of the Symptoms of climacteric syndrome, deficiency and excess is also shown in, the part of the body cavity above the diaphragm housing the heart and lungs is shown in the deficiency of lung-YIN performances such as xerostomia happiness drink, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is shown in the deficiency of the kidney yin performances such as dysphoria with feverish sensation in the chest palms and soles, companion sees the yang deficiency diseases such as coolness of extremities again simultaneously, face hectic fever, the fidgets due to deficiency difficulty symptom such as to sleep shows again to suffer from a deficiency of the kidney for disturbing in the pathogenic heat under basic state, malaise, sensation of oppression over the chest with shortness of breath illustrates the deficiency of both QI and blood of body.
In prior art, chemicals is cured the symptoms, not the disease, and easily produces hormonal medicaments toleration, and poisonous side effect of medicine is large, and it is fixed that Chinese medicine then exists uncertain therapeutic efficacy, lacks relative medicine preparation.In order to overcome above-mentioned the deficiencies in the prior art, the object of this invention is to provide and a kind ofly effectively can treat climacteric syndrome and instant effect, short treating period, Chinese medicine composition that cure rate is high.
For realizing object of the present invention, now according to following technical scheme, Chinese medicine composition of the present invention is made up of the raw material of following weight portion: Herba Leonuri 8-20 part, Rhizoma Chuanxiong 5-15 part, Radix Paeoniae Alba 5-15 part, Fructus Rubi 3-10 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Rhizoma Polygonati 5-15 part, Radix Achyranthis Bidentatae 10-20 part, Rhizoma Cyperi 3-10 part, Semen Ziziphi Spinosae 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 8-20 part, Radix Rehmanniae Preparata 5-12 part, Radix Puerariae 10-20 part, Fructus Alpiniae Oxyphyllae 3-10 part, Radix Polygalae 5-15 part, Fructus Tritici Levis 3-10 part, Fructus Ligustri Lucidi 3-10 part, Herba Epimedii 5-12 part, Fructus Lycii 10-15 part, Fructus Corni 10-20 part, Radix Saposhnikoviae 3-10 part, Fructus Schisandrae Chinensis 5-15 part, Fructus Arctii 5-15 part, Radix Astragali 5-25 part, Radix Glycyrrhizae 10-20 part.
According to the difference of Chinese medicine composition to climacteric syndrome therapeutic effect, above-mentioned Chinese medicine composition basis is preferably as follows:
Chinese medicine composition of the present invention is made up of the raw material of following preferred weight part: Herba Leonuri 15 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Rubi 7 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Rhizoma Polygonati 10 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Cyperi 7 parts, Semen Ziziphi Spinosae 15 parts, Radix Salviae Miltiorrhizae 10 parts, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, Radix Puerariae 15 parts, Fructus Alpiniae Oxyphyllae 7 parts, Radix Polygalae 10 parts, Fructus Tritici Levis 7 parts, Fructus Ligustri Lucidi 6 parts, Herba Epimedii 8 parts, Fructus Lycii 13 parts, Fructus Corni 15 parts, Radix Saposhnikoviae 7 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Arctii 10 parts, the Radix Astragali 20 parts, 15 parts, Radix Glycyrrhizae.
Chinese medicine composition of the present invention is made up of the raw material of following preferred weight part: Herba Leonuri 8 parts, Rhizoma Chuanxiong 5 parts, the Radix Paeoniae Alba 5 parts, Fructus Rubi 3 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Polygonati 5 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Cyperi 3 parts, Semen Ziziphi Spinosae 10 parts, Radix Salviae Miltiorrhizae 5 parts, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, Radix Puerariae 10 parts, Fructus Alpiniae Oxyphyllae 3 parts, Radix Polygalae 5 parts, Fructus Tritici Levis 3 parts, Fructus Ligustri Lucidi 3 parts, Herba Epimedii 5 parts, Fructus Lycii 10 parts, Fructus Corni 10 parts, Radix Saposhnikoviae 3 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Arctii 5 parts, the Radix Astragali 5 parts, 10 parts, Radix Glycyrrhizae.
Chinese medicine composition of the present invention is made up of the raw material of following preferred weight part: Herba Leonuri 20 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Fructus Rubi 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Polygonati 15 parts, Radix Achyranthis Bidentatae 20 parts, Rhizoma Cyperi 10 parts, Semen Ziziphi Spinosae 20 parts, Radix Salviae Miltiorrhizae 15 parts, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, Radix Puerariae 20 parts, Fructus Alpiniae Oxyphyllae 10 parts, Radix Polygalae 15 parts, Fructus Tritici Levis 10 parts, Fructus Ligustri Lucidi 10 parts, Herba Epimedii 12 parts, Fructus Lycii 15 parts, Fructus Corni 20 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Arctii 15 parts, the Radix Astragali 25 parts, 20 parts, Radix Glycyrrhizae.
Chinese medicine composition of the present invention is made up of the raw material of following preferred weight part: Herba Leonuri 12 parts, Rhizoma Chuanxiong 12 parts, the Radix Paeoniae Alba 10 parts, Fructus Rubi 5 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Rhizoma Polygonati 18 parts, Radix Achyranthis Bidentatae 13 parts, Rhizoma Cyperi 6 parts, Semen Ziziphi Spinosae 20 parts, Radix Salviae Miltiorrhizae 10 parts, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, Radix Puerariae 16 parts, Fructus Alpiniae Oxyphyllae 6 parts, Radix Polygalae 10 parts, Fructus Tritici Levis 5 parts, Fructus Ligustri Lucidi 8 parts, Herba Epimedii 7 parts, Fructus Lycii 8 parts, Fructus Corni 14 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Arctii 15 parts, the Radix Astragali 15 parts, 17 parts, Radix Glycyrrhizae.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.
Present invention also offers a kind of preparation method of Chinese medicine composition described above, it comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40% ~ 95% is added according to 4 ~ 9 times of coarse powder gross weight, reflux, extract, three times, return time is 2 ~ 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying.Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically, as tablet, capsule etc. in this preparation method.
The present invention also asks to protect the purposes of above-mentioned Chinese medicine composition in preparation treatment climacteric syndrome medicine.Wherein said climacteric syndrome has a kind of symptom in sleep disorder, blood stasis, fatiguability asthenia, easily aging or symptom combination.。Pharmaceutical composition of the present invention, when treating climacteric syndrome, demonstrates the activity of remarkable resisting fatigue, antioxidant radical, activating blood circulation to dissipate blood stasis and improving water flood quality.Test examples 7 of the present invention shows, give the effect that positive drug and Chinese medicine composition of the present invention all can obtain significant antifatigue effect and improving water flood quality, wherein the antifatigue effect of Chinese medicine composition high dose group of the present invention and the effect of improving water flood quality and positive controls have pole significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the effect of the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of low dose group and improving water flood quality significantly will be better than positive controls, Chinese medicine composition of the present invention has the therapeutic effect more excellent than existing medicine in the fatigue reaction reducing climacteric syndrome patient and improving water flood quality.Test examples 8 of the present invention shows, and model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (
p<0.05).Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p<0.05).Under same experiment condition, positive control drug and tablet for women's health and tranquilness group also reduce whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention.The result statistics display of liver index, model group compares with normal control, and liver index significantly increases.And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduce liver index (
p<0.01), positive control drug and Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p<0.05), but effect not as good as Chinese medicine composition of the present invention.Visible, Chinese medicine composition of the present invention in clots absorbing with reduction liver index in more excellent compared with existing medicine.Test examples 9 result display of the present invention, modeling group compares with normal group, and in corium, drawing together property of SOD obviously reduces, and MDA content obviously rises, and difference has highly significant meaning (P<0.01).Tablet for women's health and tranquilness group, Chinese medicine high group of the present invention and low group of Chinese medicine of the present invention are reducing in MDA albumen and are all having the difference of significance or very significant in increased SOD albumen, wherein the therapeutic effect of Chinese medicine composition object height group of the present invention is best, has pole significant difference compared with model group.This shows, Chinese medicine composition of the present invention obviously can strengthen the activity of corium SOD, removes too much OFR, and OFR may be stoped the infringement of Skin Cell and substrate thereof, protection skin, slow down aging.
In a word, Chinese medicine composition of the present invention, in treatment climacteric syndrome, compared with prior art has following advantage:
1) compared with the chemotherapeutic agent of Current therapeutic, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improve the compliance of climacteric syndrome patient, and improve the quality of life of patient.
2) multi-medicament component is contained in Chinese medicine composition of the present invention, action target spot is numerous, pharmacological evaluation shows it and has significant blood circulation promoting and blood stasis dispelling, antioxidant radical, defying age isoreactivity, efficiently solve the morbidity root of climacteric syndrome, it serves the effect for the treatment of both the principal and secondary aspects of a disease to the therapeutic effect of climacteric syndrome.
The present invention is that inventor is on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the summary of clinical experience for many years, obtain through repeatedly testing, therefore this medicine has unique curative effect to the climacteric syndrome that a variety of causes causes, this medicine compatibility science, curative effect is rapid, the advantage that instant effect, short treating period, cure rate are high, expense is little.
Summary of the invention
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but those skilled in the art should know, described embodiment does not also limit the present invention in any way.
(1) example of formulations part
Embodiment 1 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Herba Leonuri 8 parts, Rhizoma Chuanxiong 5 parts, the Radix Paeoniae Alba 5 parts, Fructus Rubi 3 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Polygonati 5 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Cyperi 3 parts, Semen Ziziphi Spinosae 10 parts, Radix Salviae Miltiorrhizae 5 parts, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, Radix Puerariae 10 parts, Fructus Alpiniae Oxyphyllae 3 parts, Radix Polygalae 5 parts, Fructus Tritici Levis 3 parts, Fructus Ligustri Lucidi 3 parts, Herba Epimedii 5 parts, Fructus Lycii 10 parts, Fructus Corni 10 parts, Radix Saposhnikoviae 3 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Arctii 5 parts, the Radix Astragali 5 parts, 10 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 4 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 40%, reflux, extract, three times, return time is 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
Embodiment 2 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Herba Leonuri 20 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Fructus Rubi 10 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Polygonati 15 parts, Radix Achyranthis Bidentatae 20 parts, Rhizoma Cyperi 10 parts, Semen Ziziphi Spinosae 20 parts, Radix Salviae Miltiorrhizae 15 parts, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, Radix Puerariae 20 parts, Fructus Alpiniae Oxyphyllae 10 parts, Radix Polygalae 15 parts, Fructus Tritici Levis 10 parts, Fructus Ligustri Lucidi 10 parts, Herba Epimedii 12 parts, Fructus Lycii 15 parts, Fructus Corni 20 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Arctii 15 parts, the Radix Astragali 25 parts, 20 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 90%, reflux, extract, three times, return time is 3h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
Embodiment 3 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Herba Leonuri 15 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Rubi 7 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Rhizoma Polygonati 10 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Cyperi 7 parts, Semen Ziziphi Spinosae 15 parts, Radix Salviae Miltiorrhizae 10 parts, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, Radix Puerariae 15 parts, Fructus Alpiniae Oxyphyllae 7 parts, Radix Polygalae 10 parts, Fructus Tritici Levis 7 parts, Fructus Ligustri Lucidi 6 parts, Herba Epimedii 8 parts, Fructus Lycii 13 parts, Fructus Corni 15 parts, Radix Saposhnikoviae 7 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Arctii 10 parts, the Radix Astragali 20 parts, 15 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 70%, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
Embodiment 4 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Herba Leonuri 8 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Fructus Rubi 3 parts, the Rhizoma Atractylodis Macrocephalae 25 parts, Rhizoma Polygonati 15 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Cyperi 10 parts, Semen Ziziphi Spinosae 10 parts, Radix Salviae Miltiorrhizae 10 parts, 16 parts, Poria, 12 parts, Radix Rehmanniae Preparata, Radix Puerariae 10 parts, Fructus Alpiniae Oxyphyllae 3 parts, Radix Polygalae 5 parts, Fructus Tritici Levis 10 parts, Fructus Ligustri Lucidi 10 parts, Herba Epimedii 7 parts, Fructus Lycii 10 parts, Fructus Corni 15 parts, Radix Saposhnikoviae 3 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Arctii 10 parts, the Radix Astragali 10 parts, 10 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 70%, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Adding ethanol to alcohol content is 75%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol and concentrate, add water to 1000ml, stir evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
Embodiment 5 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Herba Leonuri 12 parts, Rhizoma Chuanxiong 12 parts, the Radix Paeoniae Alba 10 parts, Fructus Rubi 5 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Rhizoma Polygonati 18 parts, Radix Achyranthis Bidentatae 13 parts, Rhizoma Cyperi 6 parts, Semen Ziziphi Spinosae 20 parts, Radix Salviae Miltiorrhizae 10 parts, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, Radix Puerariae 16 parts, Fructus Alpiniae Oxyphyllae 6 parts, Radix Polygalae 10 parts, Fructus Tritici Levis 5 parts, Fructus Ligustri Lucidi 8 parts, Herba Epimedii 7 parts, Fructus Lycii 8 parts, Fructus Corni 14 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 5 parts, Fructus Arctii 15 parts, the Radix Astragali 15 parts, 17 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 4.
Embodiment 6 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Herba Leonuri 14 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 13 parts, Fructus Rubi 6 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Rhizoma Polygonati 15 parts, Radix Achyranthis Bidentatae 20 parts, Rhizoma Cyperi 3 parts, Semen Ziziphi Spinosae 16 parts, Radix Salviae Miltiorrhizae 9 parts, 11 parts, Poria, 7 parts, Radix Rehmanniae Preparata, Radix Puerariae 16 parts, Fructus Alpiniae Oxyphyllae 7 parts, Radix Polygalae 11 parts, Fructus Tritici Levis 5 parts, Fructus Ligustri Lucidi 10 parts, Herba Epimedii 12 parts, Fructus Lycii 15 parts, Fructus Corni 16 parts, Radix Saposhnikoviae 10 parts, Fructus Schisandrae Chinensis 15 parts, Fructus Arctii 12 parts, the Radix Astragali 18 parts, 17 parts, Radix Glycyrrhizae.
Preparation technology is with embodiment 4.
(2) test examples part
The antiinflammatory action of embodiment 7 Chinese medicine composition xylol of the present invention induced mice inflammatory model
Resisting fatigue is tested: get healthy Kunming mouse, body weight 18 ~ 22g mice 50, is divided into 5 groups at random.Often organize 10, each 5 of male and female, grouping situation is in table 2.Each treated animal ig administration, positive drug group ig FUKANGNING tablet, Chinese medicine composition is respectively to exceeding the tablet prepared according to the embodiment of the present invention 1, and each group dosage is as shown in table 1, the front physiological saline solution of administration, Normal group ig normal saline.Each group of successive administration 10 days, 1h after last administration, mice being put into water temperature is that the tank of 20 DEG C is swum.Until mice sinks under water, calculate swimming time.
Sleep improvement is tested: separately get healthy Kunming mouse, body weight 20 ~ 22g mice 50, is divided into 5 groups at random, often organizes 10, male female each 5.Grouping situation and dosage design with above-mentioned anti-fatigue test, successive administration 5 days.1h after last medicine, with the dosage mice ig pentobarbital sodium of 35mg/kg, take righting reflex loss as index, record mouse sleep time.
Resisting fatigue experimental result and the sleep improvement experimental result of mice are as shown in table 1.
The resisting fatigue experimental result of table 1 Chinese medicine composition of the present invention and sleep improvement experimental result
| Group | Dosage (by crude drug gauge) | n | Swimming time | The length of one's sleep |
| Normal group | Equal-volume normal saline | 10 | 6.58±1.35 | 25.61±5.34 |
| Positive controls | 7.5mg/kg | 10 | 9.26±1.74 * | 29.34±7.54 * |
| Low group of Chinese medicine composition | 7.5mg/kg | 10 | 9.47±1.53 * | 28.39±8.24 * |
| Group in Chinese medicine composition | 10mg/kg | 10 | 11.27±1.78 **# | 32.69±6.95 **# |
| Chinese medicine composition object height group | 15 mg/kg | 10 | 13.25±1.95 **## | 35.97±8.69 **## |
Compare with model control group,
* p< 0.05; Compare with model control group,
* p< 0.01; Compare with positive controls,
# p< 0.05; Compare with positive controls,
## p< 0.01.
Result display gives positive drug and Chinese medicine composition of the present invention all can obtain significant antifatigue effect, wherein the antifatigue effect of Chinese medicine composition high dose group of the present invention and positive controls have pole significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of middle dosage group significantly will be better than positive controls, and the fatigue reaction that Chinese medicine composition of the present invention is reducing climacteric syndrome patient has the therapeutic effect more excellent than existing medicine.
Give positive drug and Chinese medicine composition of the present invention all can obtain significant sleep quality improvement result, wherein the sleep quality improvement result of Chinese medicine composition high dose group of the present invention and positive controls have pole significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of middle dosage group significantly will be better than positive controls, and Chinese medicine composition of the present invention has the therapeutic effect more excellent than existing medicine in the sleep quality improving climacteric syndrome patient.
Embodiment 8 Chinese medicine composition of the present invention is to the improvement result of rat blood stasis models
Get healthy SD rat, body weight 180-200g, 70, male and female half and half, be divided into 7 groups at random by body weight: basic, normal, high group of Normal group, model group, tablet for women's health and tranquilness group and Chinese medicine composition of the present invention (obtaining according to prescription described in the embodiment of the present invention 3 and preparation technology), often organize 10.Gastric infusion, successive administration 14 days, Normal group and model group are to 0.5%CMC, and all the other give corresponding medicine, and dosage is as shown in table 3.Administration the 13rd day, 14 days, except Normal group, all the other treated animals press 1mg/Kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 4h, and after first time injection, animal is put into 15min in 4 DEG C of frozen water by 2h.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets liver and to weigh conversion organ coefficient.
Result shows, and model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (
p<0.05).Compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p<0.05).Under same experiment condition, positive control drug and tablet for women's health and tranquilness group also reduce whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as Chinese medicine composition of the present invention.The result statistics display of liver index, model group compares with normal control, and liver index significantly increases.And compare with model group, Chinese medicine composition of the present invention each dosage group basic, normal, high significantly reduce liver index (
p<0.01), positive control drug and Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p<0.05), but effect not as good as Chinese medicine composition of the present invention.Visible, Chinese medicine composition of the present invention in clots absorbing with reduction liver index in more excellent compared with existing medicine.
Table 2 on the impact of rat blood stasis models lectin from hemolymph (
)
Note: compare with normal control, #
p< 0.05, ##
p< 0.01; Compare with model group, *
p< 0.05, * *
p< 0.01.
Table 3 on the impact of rat blood stasis models liver coefficient (
)
Note: compare with normal control, ##
p< 0.01; Compare with model group, *
p< 0.05, * *
p< 0.01.
Embodiment 9 Chinese medicine composition of the present invention is to the scavenging action of oxygen-derived free radicals
Existing known, SOD is OFR(oxygen-derived free radicals main in body) scavenger, O can be removed by specificity
2 -, reduce the generation of OH, keep balance to play vital effect to OFR metabolism.
1, animal grouping and modeling
Get 4 monthly age Japan large ear rabbit 36, body weight 2.0 ~ 2.5kg, male and female half and half (Shandong University's Experimental Animal Center provides).By randomly assigne be divided into normal group, modeling group, tablet for women's health and tranquilness group, Chinese medicine high group of the present invention, low group of Chinese medicine of the present invention, wherein Chinese drug-treated group of the present invention obtains according to prescription described in the embodiment of the present invention 5 and preparation technology, often organizes 6.Get modeling group and each treatment group rabbit is weighed, with 25% urethane (4mlkg
-1) auricular vein anaesthetizes successfully, lain on the back by rabbit and be fixed in laboratory table.In right groin place cropping, Pu poison, under mid point, lcm makes a lcm and makes longitudinal incision, appears femoral nerve blood vessel card, and free ligation stock is quiet conspicuous, sews up subcutaneous tissue and skin.
2, Therapeutic Method
Modeling was treated treatment group after 8 weeks.Gavage gives test medicine, every day 1 time, continuously treatment 3 weeks.Each treatment group administration kind and dosage as shown in table 4.
3, Testing index
After lethal for rabbit air embolism, the corium 200mg at positive middle part before getting knee joint, to dehematize liquid with freezing normal saline flushing, filter paper examination is dry, put into 2ml ice normal saline and shred corium block, pour homogenate under ice normal saline in glass homogenate tube into, make the tissue homogenate of 10%, with 3000r/min centrifugal 10 minutes, get supernatant and be stored in special survey histone in-70 DEG C of refrigerators, superoxides Souization enzyme (Superoxide ~ smutase SOD), malonaldehyde (Ma1ond Jaldehyde MDA) xanthine oxidase (Xanthine Oxldase XO) method, operate and undertaken by SOD mensuration test kit (Nanjing is built up Bioengineering Research Institute and produced) description.By thiobarbituricacidα-(Thiobarbituric acid TBA) colorimetry. operate and undertaken by MBA mensuration test kit (Nanjing is built up Bioengineering Research Institute and produced) description.
4, experimental result
In corium, SOD is active, MDA content is as shown in table 4, statistical method F inspection and q inspection, and result shows, modeling group compares with normal group, in corium, drawing together property of SOD obviously reduces, and MDA content obviously rises, and difference has highly significant meaning (P<0.01).Tablet for women's health and tranquilness group, Chinese medicine high group of the present invention and low group of Chinese medicine of the present invention are reducing in MDA albumen and are all having the difference of significance or very significant in increased SOD albumen, wherein the therapeutic effect of Chinese medicine composition object height group of the present invention is best, has pole significant difference compared with model group.This shows, Chinese medicine composition of the present invention obviously can strengthen the activity of intradermal SOD, removes too much OFR, and OFR may be stoped the infringement of Skin Cell and substrate thereof, protection skin, slow down aging.
Table 4 each treatment group corium SOD activity and MDA comparision contents
Note: compare with normal control, ##
p< 0.01; Compare with model group, *
p< 0.05, * *
p< 0.01.
The clinical therapeutic efficacy of embodiment 10 Chinese medicine composition of the present invention
For showing the therapeutic effect of Chinese medicine of the present invention to climacteric syndrome, the present inventor is to 200 routine case clinical observations, wherein women 200 people, 45 years old age---60 years old, inclusion criteria: be diagnosed as climacteric syndrome, clinical symptoms is all to warm sweating, irritable, palpitation and insomnia, poor appetite asthenia, disorder of menstrual cycle or amenorrhea.Experimental group uses embodiment 5 gained Chinese medicinal granule, one day twice, sooner or later takes half an hour after meal every day.Two groups was all 1 course for the treatment of with 30 days, evaluated curative effect after 3 courses for the treatment of.
Curative effect situation criterion: 1, fully recover: clinical symptom disappearance.2, effective: symptom takes an evident turn for the better.3, effective: symptom takes a turn for the better to some extent.4, invalid: symptom, sign are without improvement.
Drug administration method of the present invention is: Chinese medicine capsules described in the oral embodiment of the present invention 3, every day 2 times, taking medicine after meal; Each 3-4 capsule one month is a course for the treatment of.By taking medicine of the present invention, general medication 1---6 course for the treatment of, 185 people cure, and cure rate reaches 92%, and 196 people are effective, and effective percentage is 98%.
Claims (5)
1. treat the Chinese medicine composition of climacteric syndrome for one kind, it is characterized in that being obtained by the raw material of following weight portion: Herba Leonuri 15 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 10 parts, Fructus Rubi 7 parts, the Rhizoma Atractylodis Macrocephalae 18 parts, Rhizoma Polygonati 10 parts, Radix Achyranthis Bidentatae 15 parts, Rhizoma Cyperi 7 parts, Semen Ziziphi Spinosae 15 parts, Radix Salviae Miltiorrhizae 10 parts, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, Radix Puerariae 15 parts, Fructus Alpiniae Oxyphyllae 7 parts, Radix Polygalae 10 parts, Fructus Tritici Levis 7 parts, Fructus Ligustri Lucidi 6 parts, Herba Epimedii 8 parts, Fructus Lycii 13 parts, Fructus Corni 15 parts, Radix Saposhnikoviae 7 parts, Fructus Schisandrae Chinensis 10 parts, Fructus Arctii 10 parts, the Radix Astragali 20 parts, 15 parts, Radix Glycyrrhizae.
2. treat the Chinese medicine composition of climacteric syndrome as claimed in claim 1, it is characterized in that: described Chinese medicine composition is powder, water preparation, tablet or capsule.
3. prepare the method for the Chinese medicine composition for the treatment of climacteric syndrome described in claim 1 for one kind, it is characterized in that comprising the steps: that getting the above-mentioned Chinese crude drug of recipe quantity is broken into coarse powder, the alcoholic solution that volumetric concentration is 40% ~ 95% is added according to 4 ~ 9 times of coarse powder gross weight, reflux, extract, three times, return time is 2 ~ 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically in this preparation method.
4. described in claim 1, treat the purposes of Chinese medicine composition in preparation climacteric syndrome medicine of climacteric syndrome.
5. purposes as claimed in claim 4, is characterized in that: described climacteric syndrome has a kind of symptom in sleep disorder, blood stasis, fatiguability asthenia, easily aging or two or more symptom combination.
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