CN104001052A - Traditional Chinese medicine composition for treating climacteric syndrome - Google Patents
Traditional Chinese medicine composition for treating climacteric syndrome Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating climacteric syndrome, which is prepared from the following raw materials: the bark of eucommia, ligusticum wallichii, pericarpium citri reticulatae, raspberry, white atractylodes rhizome, sealwort, golden cypress, rhizoma cyperi, spina date seed, the root of red-rooted salvia, poria cocos, radix rehmanniae medicine, the root of kudzu vine, hawthorn, polygala tenuifolia, light wheat, glossy privet fruit, herba epimedii, the fruit of Chinese wolfberry, dogwood, radix sileris, schisandra chinensis, burdock, rhizoma anemarrhenae, and liquorice 1. Pharmacological experiments and clinical experiments prove that the traditional Chinese medicine composition disclosed by the invention has the obvious effect on treatment of climacteric syndrome, and therefore, the traditional Chinese medicine composition for treating climacteric syndrome has wide medical popularization value.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition that is used for the treatment of climacteric syndrome and preparation method thereof.
Background technology
Climacteric refers to that women is from having reproductive performance to the transition stage of apogeny.This stage there is change in menstrual cycle characteristics in women, as polymenorrhea, hypomenorrhea, irregular menses and amenorrhea etc.Simultaneously, climacteric women causes the variation of interior environment because of the change of Function of Ovary, have influence on the functional variation of each tract and occur corresponding symptom, as hectic fever, perspiration, the unstable symptoms of vasomotoricity such as headache, the unstable symptoms of autonomic nervous function such as cardiopalmus, dizzy, insomnia, paresthesia of skin, depression, anxiety, suspicious, self-confidence reduces, absent minded, emotional, feeling of terror spirit, the mental symptoms such as hysterical attack sample symptom even, is called climacteric syndrome.
The reason that causes menopause syndrome be exactly the variation the earliest of degeneration-climacteric of ovarian function be ovarian function decline, then just show as the disorder of various hormones, cause involutional various variation.No matter climacteric starts sooner or later, how long lasts, and always can be divided into premenopause, menopause (ischomenia) and postmenopause (after ischomenia 1 year), and to take decline gradually to the disappearance completely of ovarian function be sign.Climacteric is that women progresses into senile transition stage from period of sexual maturity (period of duration), is an important and obvious especially stage of physiological change in human senility process.As a rule, postclimacteric women there will be following four large symptoms climacteric: 1, hectic fever is the symptom that climacteric women often meets with; 2, cardiopalmus, namely nervous, be also climacteric one of modal symptom; 3, spirit, nervous symptoms performance are extremely; 4, sore waist and aching in the waist and the back is the osteoporotic early symptom of climacteric women.And climacteric series of symptoms puzzlement, had a strong impact on women physically and mentally healthy, its harm has: 1. vascular dysfunctions: paroxysm disease flushing and hectic fever, feel suddenly chest, cervical region, face heating, perspire, fear of cold, sometimes accompany cardiopalmus, uncomfortable in chest, breathe hard, the symptom such as dizzy; 2. spirit, nervous symptoms: climacteric women often have worry, depression, emotional, have a sleepless night, cry well, hypomnesis, absent-minded etc., being happy and angry uncertainly sometimes, similar phrenoplegia; 3. tumor is easily sent out: at the age occurred frequently that climacteric is kinds of tumor, common are hysteromyoma, cervical cancer, ovarian tumor etc.If find earlier, early treatment, can improve therapeutic effect and survival.
Doctor trained in Western medicine adopts " Hormone Replacement Therapy " to treat more, the Therapeutic Method of doctor trained in Western medicine is the estrogen with synthetic at present, as diethylstilbestrol, nilestriol, ethinylestradiol etc. are made replacement therapy, but the estrogen of these synthetic of life-time service, endometrium hyperplasia, metrorrhagia be can cause, cervical cancer, breast carcinoma even caused.These above-mentioned Therapeutic Method toxic and side effects are larger, halted gradually in states such as America and Europes.And Chinese medicine often can be difficult to medication to the ill, and specific aim is not strong, and therapeutic effect is general; Therefore find medicine safe, that treat climacteric syndrome effectively, comprehensively, it is one of pendulum important topic in face of vast medical research worker.
Chinese medicine is the medical science applied characteristic of China, and the method by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs has accumulated abundant clinical experience to the treatment of climacteric syndrome.Chinese medicine calls climacteric syndrome " pre-postmenstrual syndromes ", think its main pathogenesis for suffering from a deficiency of the kidney, imbalance of YIN and YANG, Therapeutic Principle should the kidney invigorating and essence nourishing, YIN and YANG balance regulating.Therefore clinically adopt Treated with Chinese Decoctions or take Chinese medicine treat this disease as main Chinese and Western compound preparation, for the medication of suffering from a deficiency of the kidney, the kidney invigorating and essence nourishing, kidney qi must be mended, equilibrium between yin and yang, thus illness must heal, and reaches the object for the treatment of both the principal and secondary aspects of a disease, and long-term taking safety is good, be therefore more and more subject to the favor of extensive patients.Climacteric syndrome, belongs to the categories such as the traditional Chinese medical science " Bulbus Lilii syndrome ", " hysteria ", " all diseases before and after menopause ", women's seventy-seven kidney qi degradations, and menses gradually exhausts, and kidney imbalance between YIN and YANG rushes conception vessel void and declines for the main pathomechanism of climacteric syndrome.Suffering from a deficiency of the kidney is the basis of morbidity, involve the five internal organs and can cause unbalance between internal organs, function of liver and spleen imbalance is the condition of morbidity, the spleen being the foundation of acquired constitution, the kidney being the origin of congenital constitution, primary disease and liver spleen kidney have close relationship, therefore the many coldheat complex of the Symptoms of climacteric syndrome, deficiency and excess is also shown in, the part of the body cavity above the diaphragm housing the heart and lungs is shown in the deficiency of lung-YIN performances such as xerostomia happiness drink, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is shown in the deficiency of the kidney yin performances such as dysphoria with feverish sensation in the chest palms and soles, companion sees the yang deficiency diseases such as coolness of extremities again simultaneously, face hectic fever, the fidgets due to deficiency difficulty symptom such as sleep shows again to suffer from a deficiency of the kidney for disturbing in the pathogenic heat under basic state, malaise, the deficiency of both QI and blood of sensation of oppression over the chest with shortness of breath explanation body.
Summary of the invention
In prior art, chemicals is cured the symptoms, not the disease, and easily produces hormonal medicaments toleration, and poisonous side effect of medicine is large, and Chinese medicine exists uncertain therapeutic efficacy fixed, lacks relative medicine preparation.In order to overcome above-mentioned the deficiencies in the prior art, the object of this invention is to provide and a kind ofly can effectively treat climacteric syndrome and instant effect, short treating period, Chinese medicine that cure rate is high.
For realizing object of the present invention, now according to following technical scheme, Chinese medicine of the present invention is to be made by the raw material of following weight portion proportioning: Cortex Eucommiae 8-20 part, Rhizoma Chuanxiong 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Fructus Rubi 3-10 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Rhizoma Polygonati 5-15 part, Cortex Phellodendri 10-20 part, Rhizoma Cyperi 3-10 part, Semen Ziziphi Spinosae 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 8-20 part, Radix Rehmanniae Preparata 5-12 part, Radix Puerariae 10-20 part, Fructus Crataegi 3-10 part, Radix Polygalae 5-15 part, Fructus Tritici Levis 3-10 part, Fructus Ligustri Lucidi 3-10 part, Herba Epimedii 5-12 part, Fructus Lycii 10-15 part, Fructus Corni 10-20 part, Radix Saposhnikoviae 3-10 part, Fructus Schisandrae Chinensis 5-15 part, Fructus Arctii 5-15 part, Rhizoma Anemarrhenae 5-25 part, Radix Glycyrrhizae 10-20 part,
Difference according to Chinese medicine composition to climacteric syndrome therapeutic effect is preferably as follows on above-mentioned Chinese medicine composition basis:
(1) 15 parts of the Cortexs Eucommiae, 10 parts of Rhizoma Chuanxiongs, 10 parts of Pericarpium Citri Reticulataes, 7 parts of Fructus Rubies, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Polygonatis, 15 parts of Cortex Phellodendris, 7 parts of Rhizoma Cyperis, 15 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Salviae Miltiorrhizaes, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, 15 parts of Radix Puerariaes, 7 parts of Fructus Crataegis, 10 parts of Radix Polygalaes, 7 parts of Fructus Tritici Levis, 6 parts of Fructus Ligustri Lucidi, 8 parts of Herba Epimedii, 13 parts of Fructus Lycii, 15 parts of Fructus Corni, 7 parts of Radix Saposhnikoviaes, 10 parts of Fructus Schisandrae Chinensis, 10 parts of Fructus Arctiis, 20 parts of the Rhizoma Anemarrhenaes, 15 parts, Radix Glycyrrhizae.
(2) 8 parts of the Cortexs Eucommiae, 5 parts of Rhizoma Chuanxiongs, 5 parts of Pericarpium Citri Reticulataes, 3 parts of Fructus Rubies, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Polygonatis, 10 parts of Cortex Phellodendris, 3 parts of Rhizoma Cyperis, 10 parts of Semen Ziziphi Spinosaes, 5 parts of Radix Salviae Miltiorrhizaes, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, 10 parts of Radix Puerariaes, 3 parts of Fructus Crataegis, 5 parts of Radix Polygalaes, 3 parts of Fructus Tritici Levis, 3 parts of Fructus Ligustri Lucidi, 5 parts of Herba Epimedii, 10 parts of Fructus Lycii, 10 parts of Fructus Corni, 3 parts of Radix Saposhnikoviaes, 5 parts of Fructus Schisandrae Chinensis, 5 parts of Fructus Arctiis, 5 parts of the Rhizoma Anemarrhenaes, 10 parts, Radix Glycyrrhizae.
(3) 20 parts of the Cortexs Eucommiae, 15 parts of Rhizoma Chuanxiongs, 15 parts of Pericarpium Citri Reticulataes, 10 parts of Fructus Rubies, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 20 parts of Cortex Phellodendris, 10 parts of Rhizoma Cyperis, 20 parts of Semen Ziziphi Spinosaes, 15 parts of Radix Salviae Miltiorrhizaes, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, 20 parts of Radix Puerariaes, 10 parts of Fructus Crataegis, 15 parts of Radix Polygalaes, 10 parts of Fructus Tritici Levis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 20 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Arctiis, 25 parts of the Rhizoma Anemarrhenaes, 20 parts, Radix Glycyrrhizae.
(4) 12 parts of the Cortexs Eucommiae, 12 parts of Rhizoma Chuanxiongs, 10 parts of Pericarpium Citri Reticulataes, 5 parts of Fructus Rubies, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Rhizoma Polygonatis, 13 parts of Cortex Phellodendris, 6 parts of Rhizoma Cyperis, 20 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 6 parts of Fructus Crataegis, 10 parts of Radix Polygalaes, 5 parts of Fructus Tritici Levis, 8 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 12 parts of Fructus Lycii, 14 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 5 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Arctiis, 15 parts of the Rhizoma Anemarrhenaes, 17 parts, Radix Glycyrrhizae.
In order to express better Chinese medicine composition of the present invention, Chinese medicine composition of the present invention can be prepared into conventional clinically dosage form.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Preferably, Chinese medicine composition of the present invention is prepared into powder, water preparation, tablet or capsule according to conventional preparation technology.
The present invention also provides a kind of preparation method of Chinese medicine composition described above, it mainly comprises following step: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, according to the 4-9 of coarse powder gross weight, doubly adding volumetric concentration is the alcoholic solution of 40%-95%, reflux, extract, three times, return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form clinically for preparing of this preparation method, as tablet, capsule etc.
The present invention also asks for protection the purposes of above-mentioned Chinese medicine composition in preparation treatment climacteric syndrome medicine.Wherein said climacteric syndrome has a kind of symptom or the symptom combination in sleep disorder, blood stasis, fatiguability asthenia, easy aging.Pharmaceutical composition of the present invention is in treatment during climacteric syndrome, the activity that demonstrates remarkable resisting fatigue, antioxidant radical, activating blood circulation to dissipate blood stasis and improve sleep quality.Drug effect embodiment 7 of the present invention shows, give the effect that positive drug and Chinese medicine composition of the present invention all can be obtained significant antifatigue effect and improve sleep quality, wherein the antifatigue effect of Chinese medicine composition high dose group of the present invention has utmost point significant difference with effect and the positive controls of improving sleep quality, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of middle dosage group will significantly be better than positive controls with the effect that improves sleep quality, Chinese medicine composition of the present invention has the therapeutic effect more excellent than existing medicine reducing climacteric syndrome patient's fatigue reaction and improve aspect sleep quality.Drug effect embodiment of the present invention 8 shows, model group and normal control comparison, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have significantly and increase (
p< 0.05).With model group comparison, basic, normal, high each dosage group of the Chinese medicine composition of the present invention all remarkable or utmost point has reduced the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity significantly, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p< 0.05).Under same experiment condition, positive control drug and tablet for women's health and tranquilness group have also reduced the high cut index of whole blood, the low cut index of whole blood, erythrocyte aggregation index, but it improves effect all not as good as Chinese medicine composition of the present invention to hemorheology index.The result statistics of liver index shows, model group and normal control comparison, and liver index significantly increases.And with model group comparison, basic, normal, high each dosage group of Chinese medicine composition of the present invention significantly reduced liver index (
p< 0.01), positive control drug and Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p< 0.05), but effect is not as good as Chinese medicine composition of the present invention.Visible, Chinese medicine composition of the present invention is compared more excellent with reduction liver index aspect aspect clots absorbing with existing medicine.Drug effect embodiment 9 results of the present invention show, modeling group and normal group comparison, and in corium, drawing together property of SOD obviously reduces, and MDA content obviously rises, and difference has highly significant meaning (P < 0.01).Tablet for women's health and tranquilness group, high group of Chinese medicine of the present invention and low group of difference all at aspect reduction MDA albumen and increased SOD albumen aspect with significance or very significant of Chinese medicine of the present invention, wherein the therapeutic effect of Chinese medicine composition object height group of the present invention is best, compares have utmost point significant difference with model group.This shows, Chinese medicine composition of the present invention can obviously strengthen the activity of corium SOD, removes too much OFR, and may stop the infringement of OFR to Skin Cell and substrate thereof, protection skin, slow down aging.
In a word, Chinese medicine composition of the present invention, aspect treatment climacteric syndrome, compared with prior art has following advantage:
1) compare with the chemotherapeutic agent of current treatment, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improved climacteric syndrome patient's compliance, and improved patient's quality of life;
2) in Chinese medicine composition of the present invention, contain multi-medicament component, action target spot is numerous, pharmacological evaluation shows that it has significant blood circulation promoting and blood stasis dispelling, antioxidant radical, defying age isoreactivity, the morbidity root that has effectively solved climacteric syndrome, its therapeutic effect to climacteric syndrome has played the effect for the treatment of both the principal and secondary aspects of a disease;
3)the present invention is that inventor is on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the summary of clinical experience for many years, through repeatedly testing, obtain, therefore the climacteric syndrome that this medicine causes a variety of causes has unique curative effect, this medicine compatibility science, curative effect is rapid, instant effect, short treating period, the advantage that cure rate is high, expense is little.
The specific embodiment
By specific embodiment, further describe the present invention below, but those skilled in the art should know, described embodiment does not also limit the present invention in any way.
one) FORMULATION EXAMPLE part
embodiment 1 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 8 parts of the Cortexs Eucommiae, 5 parts of Rhizoma Chuanxiongs, 5 parts of Pericarpium Citri Reticulataes, 3 parts of Fructus Rubies, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Polygonatis, 10 parts of Cortex Phellodendris, 3 parts of Rhizoma Cyperis, 10 parts of Semen Ziziphi Spinosaes, 5 parts of Radix Salviae Miltiorrhizaes, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, 10 parts of Radix Puerariaes, 3 parts of Fructus Crataegis, 5 parts of Radix Polygalaes, 3 parts of Fructus Tritici Levis, 3 parts of Fructus Ligustri Lucidi, 5 parts of Herba Epimedii, 10 parts of Fructus Lycii, 10 parts of Fructus Corni, 3 parts of Radix Saposhnikoviaes, 5 parts of Fructus Schisandrae Chinensis, 5 parts of Fructus Arctiis, 5 parts of the Rhizoma Anemarrhenaes, 10 parts, Radix Glycyrrhizae;
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 4 times of coarse powder gross weight is 40% alcoholic solution, reflux, extract, three times, return time is 5h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete is pulverized and added the conventional adjuvant of preparation to be prepared into tablet or capsule.
embodiment 2 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 20 parts of the Cortexs Eucommiae, 15 parts of Rhizoma Chuanxiongs, 15 parts of Pericarpium Citri Reticulataes, 10 parts of Fructus Rubies, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 20 parts of Cortex Phellodendris, 10 parts of Rhizoma Cyperis, 20 parts of Semen Ziziphi Spinosaes, 15 parts of Radix Salviae Miltiorrhizaes, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, 20 parts of Radix Puerariaes, 10 parts of Fructus Crataegis, 15 parts of Radix Polygalaes, 10 parts of Fructus Tritici Levis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 20 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Arctiis, 25 parts of the Rhizoma Anemarrhenaes, 20 parts, Radix Glycyrrhizae,
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 90% alcoholic solution, reflux, extract, three times, return time is 3h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete is pulverized and added the conventional adjuvant of preparation to be prepared into tablet or capsule.
embodiment 3 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 15 parts of the Cortexs Eucommiae, 10 parts of Rhizoma Chuanxiongs, 10 parts of Pericarpium Citri Reticulataes, 7 parts of Fructus Rubies, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Polygonatis, 15 parts of Cortex Phellodendris, 7 parts of Rhizoma Cyperis, 15 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Salviae Miltiorrhizaes, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, 15 parts of Radix Puerariaes, 7 parts of Fructus Crataegis, 10 parts of Radix Polygalaes, 7 parts of Fructus Tritici Levis, 6 parts of Fructus Ligustri Lucidi, 8 parts of Herba Epimedii, 13 parts of Fructus Lycii, 15 parts of Fructus Corni, 7 parts of Radix Saposhnikoviaes, 10 parts of Fructus Schisandrae Chinensis, 10 parts of Fructus Arctiis, 20 parts of the Rhizoma Anemarrhenaes, 15 parts, Radix Glycyrrhizae;
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 70% alcoholic solution, reflux, extract, three times, return time is 4h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete is pulverized and added the conventional adjuvant of preparation to be prepared into tablet or capsule.
embodiment 4 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 8 parts of the Cortexs Eucommiae, 15 parts of Rhizoma Chuanxiongs, 15 parts of Pericarpium Citri Reticulataes, 3 parts of Fructus Rubies, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 10 parts of Cortex Phellodendris, 10 parts of Rhizoma Cyperis, 10 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Salviae Miltiorrhizaes, 16 parts, Poria, 12 parts, Radix Rehmanniae Preparata, 10 parts of Radix Puerariaes, 3 parts of Fructus Crataegis, 5 parts of Radix Polygalaes, 10 parts of Fructus Tritici Levis, 10 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 10 parts of Fructus Lycii, 15 parts of Fructus Corni, 3 parts of Radix Saposhnikoviaes, 10 parts of Fructus Schisandrae Chinensis, 10 parts of Fructus Arctiis, 10 parts of the Rhizoma Anemarrhenaes, 10 parts, Radix Glycyrrhizae;
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 70% alcoholic solution, reflux, extract, three times, return time is 4h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Adding ethanol is 75%(v/v to containing alcohol amount), standing 24 hours, get supernatant, reclaim ethanol concentrated, add water to 1000ml, stir evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
embodiment 5 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 12 parts of the Cortexs Eucommiae, 12 parts of Rhizoma Chuanxiongs, 10 parts of Pericarpium Citri Reticulataes, 5 parts of Fructus Rubies, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 18 parts of Rhizoma Polygonatis, 13 parts of Cortex Phellodendris, 6 parts of Rhizoma Cyperis, 20 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 6 parts of Fructus Crataegis, 10 parts of Radix Polygalaes, 5 parts of Fructus Tritici Levis, 8 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 12 parts of Fructus Lycii, 14 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 5 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Arctiis, 15 parts of the Rhizoma Anemarrhenaes, 17 parts, Radix Glycyrrhizae;
Preparation method is with embodiment 4.
embodiment 6 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows:
14 parts of the Cortexs Eucommiae, 10 parts of Rhizoma Chuanxiongs, 13 parts of Pericarpium Citri Reticulataes, 6 parts of Fructus Rubies, 20 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 20 parts of Cortex Phellodendris, 3 parts of Rhizoma Cyperis, 16 parts of Semen Ziziphi Spinosaes, 9 parts of Radix Salviae Miltiorrhizaes, 11 parts, Poria, 7 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 7 parts of Fructus Crataegis, 11 parts of Radix Polygalaes, 5 parts of Fructus Tritici Levis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 16 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Fructus Schisandrae Chinensis, 12 parts of Fructus Arctiis, 18 parts of the Rhizoma Anemarrhenaes, 17 parts, Radix Glycyrrhizae;
Preparation technology is with embodiment 4.
(2) drug effect embodiment part
the antiinflammatory action of embodiment 7 Chinese medicine composition xylol of the present invention induced mice inflammatory model
Resisting fatigue experiment: get healthy Kunming mouse, 50 of body weight 18-22g mices, are divided into 5 groups at random.Every group 10, each 5 of male and female, grouping situation is in Table 2.Each treated animal ig administration, positive drug group ig FUKANGNING tablet, Chinese medicine composition is given respectively the tablet exceeding according to the embodiment of the present invention 1 preparation, and it is as shown in table 1 that each organizes dosage, uses physiological saline solution, Normal group ig equivalent normal saline before administration.Each organizes successive administration 10 days, 1h after last administration, and it is that the tank of 20 ℃ is swum that mice is put into water temperature.Until mice sinks under water, calculate swimming time.
Sleep improvement experiment: separately get healthy Kunming mouse, 50 of body weight 20-22g mices, are divided into 5 groups at random, 10 every group, male female each 5.Grouping situation and dosage design with above-mentioned anti-fatigue test, successive administration 5 days.1h after last medicine, with the dosage mice ig pentobarbital sodium of 35mg/kg, take righting reflex loss as index, records mouse sleep time.
Resisting fatigue experimental result and the sleep improvement experimental result of mice are as shown in table 1.
The resisting fatigue experimental result of table 1 Chinese medicine composition of the present invention and sleep improvement experimental result
With model control group comparison,
* p< 0.05; With model control group comparison,
* p< 0.01;
With positive controls comparison,
# p< 0.05; With positive controls comparison,
## p< 0.01.
Result demonstration gives positive drug and Chinese medicine composition of the present invention all can be obtained significant antifatigue effect, wherein the antifatigue effect of Chinese medicine composition high dose group of the present invention and positive controls have utmost point significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of middle dosage group will significantly be better than positive controls, and Chinese medicine composition of the present invention has the therapeutic effect more excellent than existing medicine in the fatigue reaction that reduces climacteric syndrome patient.
Give positive drug and Chinese medicine composition of the present invention and all can obtain significant sleep quality improvement effect, wherein the sleep quality improvement effect of Chinese medicine composition high dose group of the present invention and positive controls have utmost point significant difference, in Chinese medicine composition, dosage group and positive controls have significant difference, this shows that the high dose group of Chinese medicine composition of the present invention and the antifatigue effect of middle dosage group will significantly be better than positive controls, and Chinese medicine composition of the present invention has the therapeutic effect more excellent than existing medicine improving aspect climacteric syndrome patient's sleep quality.
the improvement effect of embodiment 8 Chinese medicine composition of the present invention to rat blood stasis models
Get healthy SD rat, body weight 180-200g, 60, male and female half and half, by body weight, be divided at random 6 groups: Normal group, model group, tablet for women's health and tranquilness group and basic, normal, high group of Chinese medicine composition of the present invention (making according to prescription and preparation technology described in the embodiment of the present invention 3), 10 every group.Gastric infusion, successive administration 14 days, Normal group and model group are to 0.5%CMC, and all the other give corresponding medicine, and dosage is as shown in table 3.Administration the 13rd day, 14 days, except Normal group, all the other treated animals are pressed 1mg/Kg subcutaneous injection adrenalin hydrochloride, and 2 times/day, interval 4h, after injection, 2h puts animal in 4 ℃ of frozen water 15min for the first time.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets the liver conversion organ coefficient of weighing.
Result shows, model group and normal control comparison, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have significantly and increase (
p< 0.05).With model group comparison, basic, normal, high each dosage group of the Chinese medicine composition of the present invention all remarkable or utmost point has reduced the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity significantly, reduction amplitude amount effect relationship, wherein high dose there were significant differences (
p< 0.05).Under same experiment condition, positive control drug and tablet for women's health and tranquilness group have also reduced the high cut index of whole blood, the low cut index of whole blood, erythrocyte aggregation index, but it improves effect all not as good as Chinese medicine composition of the present invention to hemorheology index.The result statistics of liver index shows, model group and normal control comparison, and liver index significantly increases.And with model group comparison, basic, normal, high each dosage group of Chinese medicine composition of the present invention significantly reduced liver index (
p< 0.01), positive control drug and Chinese medicine composition high dose group of the present invention can reduce significantly liver index (
p< 0.05), but effect is not as good as Chinese medicine composition of the present invention.Visible, Chinese medicine composition of the present invention is compared more excellent with reduction liver index aspect aspect clots absorbing with existing medicine.
the impact that table 2 becomes rat blood stasis models blood flow (
)
Note: with normal control comparison, #
p< 0.05, ##
p< 0.01; With model group comparison, *
p< 0.05, * *
p< 0.01
table 3 on the impact of rat blood stasis models liver coefficient (
)
Note: with normal control comparison, ##
p< 0.01; With model group comparison, *
p< 0.05, * *
p< 0.01
the scavenging action of embodiment 9 Chinese medicine composition of the present invention to oxygen-derived free radicals
Existing known, SOD is main OFR(oxygen-derived free radicals in body) scavenger, can remove O by specificity
2 -, reduce the generation of OH, to OFR metabolism, keep balance to play vital effect.
1, animal grouping and modeling
Get 36 of 4 monthly age Japan large ear rabbits, body weight 2.0-2.5kg, male and female half and half (Shandong University's Experimental Animal Center provides).By randomly assigne, be divided in normal group, modeling group, tablet for women's health and tranquilness group, high group of Chinese medicine of the present invention, Chinese medicine of the present invention low group of group, Chinese medicine of the present invention, wherein Chinese drug-treated group of the present invention makes according to prescription and preparation technology described in the embodiment of the present invention 5,6 every group.Get modeling group and each treatment group rabbit and weigh, with 25% urethane (4mlkg
-1) after auricular vein anaesthetizes successfully, rabbit is lain on the back and is fixed in laboratory table.In the place's cropping of right groin, Pu poison, under mid point, lcm makes a lcm and makes longitudinal incision, appears femoral nerve blood vessel card, and free ligation thigh is quiet conspicuous, sews up subcutaneous tissue and skin.
2, Therapeutic Method
Modeling was treated treatment group after 8 weeks.Gavage gives tested medicine, every day 1 time, treats continuously 3 weeks.Each treatment group administration classification and dosage are as shown in table 4.
3, detect index
After rabbit air embolism is lethal, get the corium 200mg at the front positive middle part of knee joint, with the freezing normal saline flushing liquid of dehematizing, filter paper examination is dry, put into 2ml ice normal saline and shred corium piece, pour homogenate under ice normal saline in glass homogenate tube into, make 10% tissue homogenate, with 3000r/min centrifugal 10 minutes, get supernatant and be stored in the special histone of surveying in-70 ℃ of refrigerators, superoxides Souization enzyme (Superoxide ~ smutase SOD), xanthine oxidase (Xanthine Oxldase XO) method for malonaldehyde (Ma1ond Jaldehyde MDA), operation is measured test kit (Nanjing is built up Bioengineering Research Institute and produced) description by SOD and is carried out.By thiobarbituricacidα-(Thiobarbituric acid TBA) colorimetry. operation is measured test kit (Nanjing is built up Bioengineering Research Institute and produced) description by MBA and is carried out.
4, experimental result
In corium, SOD is active, MDA content is as shown in table 4, F check and q check for statistical method, and result shows, modeling group and normal group comparison, in corium, drawing together property of SOD obviously reduces, and MDA content obviously rises, and difference has highly significant meaning (P < 0.01).Tablet for women's health and tranquilness group, high group of Chinese medicine of the present invention and low group of difference all at aspect reduction MDA albumen and increased SOD albumen aspect with significance or very significant of Chinese medicine of the present invention, wherein the therapeutic effect of Chinese medicine composition object height group of the present invention is best, compares have utmost point significant difference with model group.This shows, Chinese medicine composition of the present invention can obviously strengthen the activity of intradermal SOD, removes too much OFR, and may stop the infringement of OFR to Skin Cell and substrate thereof, protection skin, slow down aging.
Each treatment group corium of table 4 SOD activity and the comparison of MDA content
Note: with normal control comparison, ##
p< 0.01; With model group comparison, *
p< 0.05, * *
p< 0.01.
the clinical therapeutic efficacy of embodiment 10 Chinese medicine compositions of the present invention
For showing the therapeutic effect of Chinese medicine of the present invention to climacteric syndrome, the inventor is to 200 routine case clinical observations, women 200 people wherein, 45 years old-60 years old age, inclusion criteria: be diagnosed as climacteric syndrome, clinical symptoms all be take and warmed sweating, irritated irritability, palpitation and insomnia, poor appetite asthenia, disorder of menstrual cycle or amenorrhea as main.Experimental group is used embodiment 5 gained Chinese medicinal granules, one day twice, every day, sooner or later takes half an hour after meal.All take 30 days as 1 course for the treatment of, after 3 courses for the treatment of, evaluate curative effect for two groups.
Curative effect situation criterion: 1, recovery from illness: clinical symptom disappearance; 2, effective: symptom takes an evident turn for the better; 3, effective: symptom takes a turn for the better to some extent; 4, invalid: symptom, sign are without improvement.
Drug administration method of the present invention is: Chinese medicine capsules described in the oral embodiment of the present invention 3, every day 2 times, taking medicine after meal; Each 3-4 capsule one month is a course for the treatment of.By taking medicine of the present invention, general medication 1-6 course for the treatment of, 185 people's healings, it is effective that cure rate reaches 92%, 196 people, and effective percentage is 98%.
Claims (9)
1. a Chinese medicine composition for the treatment of climacteric syndrome, it is characterized in that described Chinese medicine composition is mainly made by the raw material of following weight portion: Cortex Eucommiae 8-20 part, Rhizoma Chuanxiong 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Fructus Rubi 3-10 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Rhizoma Polygonati 5-15 part, Cortex Phellodendri 10-20 part, Rhizoma Cyperi 3-10 part, Semen Ziziphi Spinosae 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 8-20 part, Radix Rehmanniae Preparata 5-12 part, Radix Puerariae 10-20 part, Fructus Crataegi 3-10 part, Radix Polygalae 5-15 part, Fructus Tritici Levis 3-10 part, Fructus Ligustri Lucidi 3-10 part, Herba Epimedii 5-12 part, Fructus Lycii 10-15 part, Fructus Corni 10-20 part, Radix Saposhnikoviae 3-10 part, Fructus Schisandrae Chinensis 5-15 part, Fructus Arctii 5-15 part, Rhizoma Anemarrhenae 5-25 part, Radix Glycyrrhizae 10-20 part.
2. the Chinese medicine composition for the treatment of climacteric syndrome as claimed in claim 1, it is characterized in that described Chinese medicine composition is mainly made by the raw material of following weight portion: 15 parts of the Cortexs Eucommiae, 10 parts of Rhizoma Chuanxiongs, 10 parts of Pericarpium Citri Reticulataes, 7 parts of Fructus Rubies, 18 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Polygonatis, 15 parts of Cortex Phellodendris, 7 parts of Rhizoma Cyperis, 15 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Salviae Miltiorrhizaes, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, 15 parts of Radix Puerariaes, 7 parts of Fructus Crataegis, 10 parts of Radix Polygalaes, 7 parts of Fructus Tritici Levis, 6 parts of Fructus Ligustri Lucidi, 8 parts of Herba Epimedii, 13 parts of Fructus Lycii, 15 parts of Fructus Corni, 7 parts of Radix Saposhnikoviaes, 10 parts of Fructus Schisandrae Chinensis, 10 parts of Fructus Arctiis, 20 parts of the Rhizoma Anemarrhenaes, 15 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of climacteric syndrome as claimed in claim 1, it is characterized in that described Chinese medicine composition is mainly made by the raw material of following weight portion: 8 parts of the Cortexs Eucommiae, 5 parts of Rhizoma Chuanxiongs, 5 parts of Pericarpium Citri Reticulataes, 3 parts of Fructus Rubies, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 5 parts of Rhizoma Polygonatis, 10 parts of Cortex Phellodendris, 3 parts of Rhizoma Cyperis, 10 parts of Semen Ziziphi Spinosaes, 5 parts of Radix Salviae Miltiorrhizaes, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, 10 parts of Radix Puerariaes, 3 parts of Fructus Crataegis, 5 parts of Radix Polygalaes, 3 parts of Fructus Tritici Levis, 3 parts of Fructus Ligustri Lucidi, 5 parts of Herba Epimedii, 10 parts of Fructus Lycii, 10 parts of Fructus Corni, 3 parts of Radix Saposhnikoviaes, 5 parts of Fructus Schisandrae Chinensis, 5 parts of Fructus Arctiis, 5 parts of the Rhizoma Anemarrhenaes, 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of climacteric syndrome as claimed in claim 1, it is characterized in that described Chinese medicine composition is mainly made by the raw material of following weight portion: 20 parts of the Cortexs Eucommiae, 15 parts of Rhizoma Chuanxiongs, 15 parts of Pericarpium Citri Reticulataes, 10 parts of Fructus Rubies, 25 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Polygonatis, 20 parts of Cortex Phellodendris, 10 parts of Rhizoma Cyperis, 20 parts of Semen Ziziphi Spinosaes, 15 parts of Radix Salviae Miltiorrhizaes, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, 20 parts of Radix Puerariaes, 10 parts of Fructus Crataegis, 15 parts of Radix Polygalaes, 10 parts of Fructus Tritici Levis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 20 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Arctiis, 25 parts of the Rhizoma Anemarrhenaes, 20 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition for the treatment of climacteric syndrome as claimed in claim 1, it is characterized in that described Chinese medicine composition is mainly made by the raw material of following weight portion: 12 parts of the Cortexs Eucommiae, 12 parts of Rhizoma Chuanxiongs, 10 parts of Pericarpium Citri Reticulataes, 5 parts of Fructus Rubies, 16 parts of the Rhizoma Atractylodis Macrocephalaes, 8 parts of Rhizoma Polygonatis, 13 parts of Cortex Phellodendris, 6 parts of Rhizoma Cyperis, 20 parts of Semen Ziziphi Spinosaes, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 6 parts of Fructus Crataegis, 10 parts of Radix Polygalaes, 5 parts of Fructus Tritici Levis, 8 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 12 parts of Fructus Lycii, 14 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 5 parts of Fructus Schisandrae Chinensis, 15 parts of Fructus Arctiis, 15 parts of the Rhizoma Anemarrhenaes, 17 parts, Radix Glycyrrhizae.
6. the Chinese medicine composition of the treatment climacteric syndrome as described in as arbitrary in claim 1-5, is characterized in that: described Chinese medicine composition is powder, water preparation, tablet or capsule.
7. a method of preparing the Chinese medicine composition of the arbitrary described treatment climacteric syndrome of claim 1-5, it is characterized in that described preparation method comprises the steps: to get the above-mentioned Chinese crude drug of recipe quantity and is broken into coarse powder, according to the 4-9 of coarse powder gross weight, doubly adding volumetric concentration is the alcoholic solution of 40%-95%, reflux, extract, three times, return time is 2-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form clinically for preparing of this preparation method.
8. the arbitrary described Chinese medicine composition of claim 1-5 is treated the purposes in climacteric syndrome medicine in preparation.
9. purposes as claimed in claim 8, is characterized in that: described climacteric syndrome has a kind of symptom or the combination of two or more symptom in sleep disorder, blood stasis, fatiguability asthenia, easy aging.
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