CN104547960A - Qi tonifying and meridian unblocking medicament for patients with hyperlipidemia and preparation method of medicament - Google Patents

Abstract

The invention discloses a qi tonifying and meridian unblocking medicament for patients with hyperlipidemia. The medicament is mainly prepared from the following raw materials in parts by weight: 10-15 parts of eucommiae bark, 6-9 parts of black nightshade herb, 5-10 parts of amomum cardamomum, 8-12 parts of motherwort fruit, 10-20 parts of polygonum multiflorum, 12-25 parts of rhizoma polygonati, 6-9 parts of celery root, 8-12 parts of curcuma aromatica, 5-10 parts of parasitic loranthus, 3-6 parts of peanut herb, 8-12 parts of glossy privet fruit, 4-8 parts of tea tree root, 10-20 parts of dendrobe, 10-25 parts of radix polygonati officinalis, 8-16 parts of raspberry, 10-15 parts of seed of Chinese dodder and 4-6 parts of (calcined) oyster. According to the theory of traditional Chinese medicine, various traditional Chinese medicinal materials are adopted and are dialectically combined, so that the medicament disclosed by the invention has the functions of promoting blood circulation and removing stasis, tonifying qi and unblocking meridians, invigorating spleen and removing phlegm, promoting qi circulation and eliminating stagnation, lowering blood lipid and improving blood circulation.

Description

hyperlipemic patients supplementing qi and invigorating vasculum medicament and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of hyperlipemic patients supplementing qi and invigorating vasculum medicament and preparation method.

Background technology

Because lipid metabolism or running make one or more lipids of blood plasma higher than being normally called hyperlipemia extremely, lipid is insoluble or be slightly soluble in water and must exist with lipoprotein form with protein bound, therefore, hyperlipemia is often hyperlipoproteinemia, show as hypercholesterolemia, hypertriglyceridemia or both have concurrently, directly can cause the disease of some serious harm healths, as atherosclerosis, coronary heart disease, pancreatitis etc.Hyperlipemia can be divided into constitutional and Secondary cases two class.Constitutional is relevant with heredity, is due to single-gene defect or polygenes defect, makes the receptor of the transhipment of participation lipoprotein and metabolism, enzyme or apolipoprotein caused by abnormal, or causes due to environmental factors (diet, nutrition, medicine) with by unknown mechanism.Secondary cases is multiple is born in metabolic disorder disease (diabetes, hypertension, myxedema, obesity, hepatorenal disease, adrenal cortex function are hyperfunction), or with other factor age, sex, drink, smoking, diet, physical exertion, psychentonia etc. be relevant.The clinical manifestation of hyperlipemia is the xanthoma of lipid caused by intradermal deposition and the arteriosclerosis of lipid caused by blood vessel endothelium deposition mainly.Although hyperlipemia can cause xanthoma, its incidence rate is not high; And atherosclerotic generation and development are slowly progressive processes.Therefore under normal conditions, most of patients non-evident sympton and abnormal sign.Many people raise owing to just finding that there is blood plasma lipoprotein level when other reasons carries out blood biochemical inspection.

A large amount of research data shows, hyperlipidemia is the risk factor of apoplexy, coronary heart disease, myocardial infarction, sudden death.In addition, hyperlipidemia is also the important risk factor promoting hypertension, impaired glucose tolerance, diabetes.Hyperlipidemia also can cause fatty liver, liver cirrhosis, cholelithiasis, pancreatitis, retinal hemorrhage, blind, peripheral vascular disease, limping, hyperuricemia.

Hyperlipidemia is the Major Risk Factors causing human atherosclerosis's property disease.Have as common atherosclerosis: coronary heart disease (comprising myocardial infarction, angina pectoris and sudden death), cerebral infarction and peripheral vessels thrombotic disease.The sickness rate of these cardiac and cerebral vascular diseases is high, and harm is large, and disease progression is dangerous, about its mortality rate accounts for the half of mankind's general mortality rate.If hyperlipoidemia, easily cause blood thick, blood vessel wall deposits, form little speckle (being exactly " atherosclerosis " that we often say) gradually, these specklees increase increase, gradually artery-clogging, make blood flow slack-off, time serious, blood flow is interrupted, if this situation occurs in heart just cause coronary heart disease; Occur in brain and just there will be apoplexy; If blocking optical fundus blood vessel will cause visual deterioration, blind; If occur in kidney will cause renal arteriosclerosis, renal failure; Occur in lower limb and there will be limb necrosis, fester.In addition, hyperlipidemia can cause hypertension, brings out cholelithiasis, and pancreatitis increases the weight of hepatitis, causes male sexual disorder, the diseases such as senile dementia, and current research prompting hyperlipidemia may be relevant with the morbidity of cancer.

The Measures compare of existing Chinese traditional treatment hyperlipidemia is many, for the problems referred to above, publication number CN 102526639 A (application number 201210063469.0) patent document discloses a kind of Chinese medicine composition for the treatment of hyperlipidemia and preparation method thereof, comprising: Fructus Crataegi, the Radix Astragali, Semen Lepidii (Semen Descurainiae), Rhizoma Curcumae Longae, Pollen Typhae, Hirudo, Radix Rhapontici, Fructus Ligustri Lucidi, rush down pool, Poria, Herba Dendrobii, Herba Ecliptae, Radix Rubiae, Rhizoma Corydalis and the Radix Pulsatillae.Publication number CN 103301220 A(application number 201310184104.8) patent document discloses a kind of herbal mediciment for the treatment of hyperlipidemia and preparation method thereof, be made up of the raw material making effective ingredient of following weight portion: Andrias davidianus Blanchard meat powder 18-22 part, Radix Polygoni Multiflori Preparata 14-16 part, Fructus Ligustri Lucidi 13-15 part, Herba Taxilli 14-16 part, Fructus Crataegi 18-21 part, its preparation method comprises the following steps: the Andrias davidianus Blanchard after butchering is cleaned, removes the peel, removes internal organs by (1), Andrias davidianus Blanchard is cooked being no more than at the temperature of 90 DEG C, then pick a bone, smash, drying, obtained Andrias davidianus Blanchard meat powder; (2) Radix Polygoni Multiflori Preparata, Fructus Ligustri Lucidi, Herba Taxilli, Fructus Crataegi are boiled risen with adding water big fire, material water weight ratio 1:2-3, then slow fire decocts 30-40 minute, filters; (3) by step (1), (2) gained Andrias davidianus Blanchard meat powder and filtrate mixing, slow fire endures 12-26 minute again.Publication number CN 102670869 A (application number 201210182131.7) patent document discloses a kind of alleviation hyperlipidemia Pollen Typhae Chinese medicine oral liquid and preparation method, is be prepared from by the raw material of Chinese medicine of following parts by weight: Radix Et Rhizoma Rhei 30-50 part, Semen Cassiae 50-100 part, Pollen Typhae 150-300 part, Fructus Ligustri Lucidi 150-300 part, Fructus Mori 150-300 part.

The prior art comprising above-mentioned patent documentation achieves certain achievement in treatment hyperlipidemia, also a lot of medicine is had, Western medicine has advantage that is rapid-action, Be very effective in treatment hyperlipidemia, but side effect is comparatively large, the lipid lowerers as Statins and Bei Te class all likely causes myositis or brain soldier.Current Chinese medicine also exists the difficult problems such as the course of disease is long, refractory is healed, easy recurrence.

Summary of the invention

For the deficiency of existing treatment hyperlipidemia, an object of the present invention is to provide a kind of hyperlipemic patients supplementing qi and invigorating vasculum medicament, there is blood circulation promoting and blood stasis dispelling, supplementing qi and invigorating vasculum, invigorating the spleen for dissipating phlegm, promoting QI to circulate and dispersing the agglomeration of the pathogens, reduction blood fat, improve sanguimotor effect, for hyperlipidemia treatment on have remarkable result, and be free from side effects, treatment cycle is short, not easily recurs.Another object is just to provide the preparation method of above-mentioned hyperlipemic patients supplementing qi and invigorating vasculum medicament.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Hyperlipemic patients supplementing qi and invigorating vasculum medicament, takes off the primary raw material stating weight proportion and is prepared from: Cortex Eucommiae 10-15 part; Herba Solani Nigri 6-9 part; Fructus Amomi Rotundus 5-10 part; Fructus Leonuri 8-12 part; Radix Polygoni Multiflori 10-20 part; Rhizoma Polygonati 12-25 part; Root of Herba Apii graveolentis 6-9 part; Radix Curcumae 8-12 part; Herba Taxilli 5-10 part; Semen arachidis hypogaeae herb 3-6 part; Fructus Ligustri Lucidi 8-12 part; Radix Camelliae sinensis 4-8 part; Herba Dendrobii 10-20 part; Rhizoma Polygonati Odorati 10-25 part; Fructus Rubi 8-16 part; Semen Cuscutae 10-15 part; (forging) Concha Ostreae 4-6 part.

Hyperlipemic patients supplementing qi and invigorating vasculum medicament, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Cortex Eucommiae 11-14 part; Herba Solani Nigri 7-8 part; Fructus Amomi Rotundus 6-9 part; Fructus Leonuri 9-11 part; Radix Polygoni Multiflori 13-17 part; Rhizoma Polygonati 17-20 part; Root of Herba Apii graveolentis 7-8 part; Radix Curcumae 9-11 part; Herba Taxilli 6-9 part; Semen arachidis hypogaeae herb 4-5 part; Fructus Ligustri Lucidi 9-11 part; Radix Camelliae sinensis 5-7 part; Herba Dendrobii 13-17 part; Rhizoma Polygonati Odorati 15-20 part; Fructus Rubi 11-13 part; Semen Cuscutae 11-14 part; (forging) Concha Ostreae 4.5-5.5 part.

Hyperlipemic patients supplementing qi and invigorating vasculum medicament, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: the Cortex Eucommiae 12 parts; Herba Solani Nigri 7.5 parts; Fructus Amomi Rotundus 8 parts; Fructus Leonuri 10 parts; Radix Polygoni Multiflori 15 parts; Rhizoma Polygonati 18 parts; Root of Herba Apii graveolentis 7.5 parts; Radix Curcumae 10 parts; Herba Taxilli 7 parts; Semen arachidis hypogaeae herb 4.5 parts; Fructus Ligustri Lucidi 10 parts; Radix Camelliae sinensis 6 parts; Herba Dendrobii 15 parts; Rhizoma Polygonati Odorati 17 parts; Fructus Rubi 12 parts; Semen Cuscutae 13 parts; (forging) Concha Ostreae 5 parts.

Present invention also offers the preparation method above-mentioned hyperlipemic patients supplementing qi and invigorating vasculum medicament being made pharmaceutically acceptable decoction, tablet, oral liquid and capsule.

The preparation method of described hyperlipemic patients supplementing qi and invigorating vasculum medicament decoction, step is as follows:

(1) be placed in container by Cortex Eucommiae block, add saline and mix thoroughly, exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, and with water spray fire extinguishing star, taking-up is dried, and grinds, and crosses 120-160 mesh sieve (preferred cross 130-150 mesh sieve, be more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) step (1) gained fine powder is joined in step (4) gained filtrate, mix homogeneously, filter, sterile packaged.

According to preparation method recited above, preferred scheme is: the consumption of step (1) preferred salt is the 2%-4% of Cortex Eucommiae quality, and the consumption being more preferably salt is 3% of Cortex Eucommiae quality.

Instructions of taking: each 200-300ml, every day 3 times, 7 days courses for the treatment of.

The preparation method of described hyperlipemic patients supplementing qi and invigorating vasculum medicament tablet, step is as follows:

(1) Cortex Eucommiae block is placed in container, add saline and mix that (consumption of preferred salt is the 2%-4% of Cortex Eucommiae quality thoroughly, the consumption being more preferably salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, with water spray fire extinguishing star, taking-up is dried, grind, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) step (1) gained fine powder is joined in step (4) gained filtrate, mix homogeneously, being condensed into relative density is 1.20-1.40(45 DEG C) the thick paste of thick paste (being preferably condensed into relative density is 1.25-1.35(45 DEG C), being more preferably and being condensed into relative density is 1.30(45 DEG C) thick paste), make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 7 days courses for the treatment of.

The preparation method of described hyperlipemic patients supplementing qi and invigorating vasculum oral medicine liquid, step is as follows:

(1) Cortex Eucommiae block is placed in container, add saline and mix that (consumption of preferred salt is the 2%-4% of Cortex Eucommiae quality thoroughly, the consumption being more preferably salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, with water spray fire extinguishing star, taking-up is dried, grind, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) step (1) gained fine powder is joined step (4) gained medicated powder mix homogeneously, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferred 13-17 minute is more preferably 15 minutes), carries out sterile packaged with the dosage often propping up 6ml.

According to preparation method recited above, preferred scheme is: the consumption of step (5) preferred sodium benzoate is the 0.1%-0.3% of concentrated solution quality, correctives uses xylitol, consumption is the 6%-8% of concentrated solution quality, the consumption being more preferably sodium benzoate is 0.2% of concentrated solution quality, correctives uses xylitol, and consumption is 7% of concentrated solution quality.

Instructions of taking: each one, every day 3 times, 7 days courses for the treatment of.

The preparation method of described hyperlipemic patients supplementing qi and invigorating vasculum drug capsule, step is as follows:

(1) Cortex Eucommiae block is placed in container, add saline and mix that (consumption of preferred salt is the 2%-4% of Cortex Eucommiae quality thoroughly, the consumption being more preferably salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, with water spray fire extinguishing star, taking-up is dried, grind, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) join in step (4) gained filtrate by step (1) gained fine powder, mix homogeneously, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

According to preparation method recited above, preferred scheme is: step (5) is preferably concentrated into the thick paste of relative density 1.25-1.35, is more preferably the thick paste being concentrated into relative density 1.30.

Using method: each 2-3 grain, every day 3 times, 7 days courses for the treatment of.

Beneficial effect of the present invention is mainly reflected in:

1, the present invention is according to traditional Chinese medical science traditional theory, and adopt several kinds of Chinese medicinal materials, dialectical compatibility, has blood circulation promoting and blood stasis dispelling, supplementing qi and invigorating vasculum, invigorating the spleen for dissipating phlegm, promoting QI to circulate and dispersing the agglomeration of the pathogens, reduction blood fat, improves sanguimotor effect.

2, the present invention is for hyperlipidemia treatment has remarkable result, and be free from side effects, treatment cycle is short, not easily recurs.

3, facts have proved that this compatibility of drugs is reasonable, synergy is good, effectively can treat hyperlipidemia.

4, the present invention is pure Chinese medicinal preparation, and therapeutic process is simple, decreases patient's slight illness.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1hyperlipemic patients supplementing qi and invigorating vasculum medicament, takes off and states primary raw material and be prepared from (getting 50g for every part): the Cortex Eucommiae 10 parts; Herba Solani Nigri 6 parts; Fructus Amomi Rotundus 5 parts; Fructus Leonuri 8 parts; Radix Polygoni Multiflori 10 parts; Rhizoma Polygonati 12 parts; Root of Herba Apii graveolentis 6 parts; Radix Curcumae 8 parts; Herba Taxilli 5 parts; Semen arachidis hypogaeae herb 3 parts; Fructus Ligustri Lucidi 8 parts; Radix Camelliae sinensis 4 parts; Herba Dendrobii 10 parts; Rhizoma Polygonati Odorati 10 parts; Fructus Rubi 8 parts; Semen Cuscutae 10 parts; (forging) Concha Ostreae 4 parts.

The preparation method of above-mentioned hyperlipemic patients supplementing qi and invigorating vasculum medicament decoction, step is as follows:

(1) be placed in container by Cortex Eucommiae block, add saline and mix thoroughly (consumption of salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, and with water spray fire extinguishing star, taking-up is dried, and grinds, and crosses 140 mesh sieves;

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the lamellar of thick 3mm, are placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water of 80 DEG C into, soak 30 minutes, filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 40 minutes, add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 30 minutes at every turn, twice filtrate merges, and leaves standstill 5 hours, gets supernatant;

(5) step (1) gained fine powder is joined in step (4) gained filtrate, mix homogeneously, filter, sterile packaged.

Instructions of taking: each 200-300ml, every day 3 times, 7 days courses for the treatment of.

model case one:literary composition XX, man, 58 years old, Baoding, Hebei province Fuping County people.There is uncomfortable in chest, anterior pectorial region malaise symptoms after fatigue or time angry over 3 years, can alleviate after rest.Once arrive local hospital inspection, be diagnosed as coronary heart disease.After drug administration, symptom is alleviated to some extent, and symptom uncomfortable in chest was interrupted and was occurred period, each outbreak all with nervous, the symptom such as to breathe hard, each lasting about 2-5 minute.That looked into afterwards suffers from hyperlipemia.

After taking 2 courses for the treatment of of gained hyperlipemic patients supplementing qi and invigorating vasculum medicament decoction (embodiment 1) of the present invention, patient is uncomfortable in chest, and palpitation and short breath attack times reduces to some extent, and the mental status is good.After continuing to take 1 course for the treatment of, uncomfortable in chest, palpitation and short breath symptom is obviously improved.Attack times obviously reduces, and degree uncomfortable in chest reduces, and time shorten, can alleviate after rest.After adhering to again taking 2 courses for the treatment of, substantially without sensation of oppression over the chest with shortness of breath symptom.Later stage visits and learns that period is without uncomfortable reaction.

embodiment 2hyperlipemic patients supplementing qi and invigorating vasculum medicament, takes off and states primary raw material and be prepared from (getting 30g for every part): the Cortex Eucommiae 11 parts; Herba Solani Nigri 7 parts; Fructus Amomi Rotundus 6 parts; Fructus Leonuri 9 parts; Radix Polygoni Multiflori 13 parts; Rhizoma Polygonati 17 parts; Root of Herba Apii graveolentis 7 parts; Radix Curcumae 9 parts; Herba Taxilli 6 parts; Semen arachidis hypogaeae herb 4 parts; Fructus Ligustri Lucidi 9 parts; Radix Camelliae sinensis 5 parts; Herba Dendrobii 13 parts; Rhizoma Polygonati Odorati 15 parts; Fructus Rubi 11 parts; Semen Cuscutae 11 parts; (forging) Concha Ostreae 4.5 parts.

The preparation method of above-mentioned hyperlipemic patients supplementing qi and invigorating vasculum medicament tablet, step is as follows:

(1) be placed in container by Cortex Eucommiae block, add saline and mix thoroughly (consumption of preferred salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, and with water spray fire extinguishing star, taking-up is dried, and grinds, and crosses 140 mesh sieves;

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the lamellar of thick 3mm, are placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water of 80 DEG C into, soak 30 minutes, filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 40 minutes, add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 30 minutes at every turn, twice filtrate merges, and leaves standstill 5 hours, gets supernatant;

(5) join in step (4) gained filtrate by step (1) gained fine powder, mix homogeneously, being condensed into relative density is 1.30(45 DEG C) thick paste, make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 7 days courses for the treatment of.

model case two:grandson XX, female, 49 years old, Langfang City people from Bazhou City of Hebei province.Suffer from diabetes more than 8 years, recent exacerbation of symptoms, as about fasting glucose 9.4mmol/L, usually there is the symptoms such as weak, nervous, dizzy, the two numbness of lower limbs of companion, hypomnesis, insomnia and dreamful sleep, dry pharynx, dry mouth, local hospital checks blood glucose 10.1mmol/L, blood fat T-CHOL 10.8mmol/L, blood plasma viscosity 3.56mpa.s, is diagnosed as hypertension, hyperlipemia, and treatment has no improvement after half a year.

Friend is listened to introduce gained hyperlipemic patients supplementing qi and invigorating vasculum medicament of the present invention very good to hyperlipidemia therapeutic effect.After taking 2 courses for the treatment of of gained hyperlipemic patients supplementing qi and invigorating vasculum medicament tablet (embodiment 2) of the present invention, blood fat obviously declines, and dizzy, the malaise symptoms such as weak pair of numbness of lower limbs obviously alleviate.After continuing to take 2 courses for the treatment of, dizzy, the malaise symptoms such as weak pair of numbness of lower limbs disappear completely, and blood fat T-CHOL, blood plasma viscosity are down to normally, and blood glucose also declines substantially.

embodiment 3hyperlipemic patients supplementing qi and invigorating vasculum medicament, takes off and states primary raw material and be prepared from (getting 20g for every part): the Cortex Eucommiae 14 parts; Herba Solani Nigri 8 parts; Fructus Amomi Rotundus 9 parts; Fructus Leonuri 11 parts; Radix Polygoni Multiflori 17 parts; Rhizoma Polygonati-20 parts; Root of Herba Apii graveolentis 8 parts; Radix Curcumae 11 parts; Herba Taxilli 9 parts; Semen arachidis hypogaeae herb 5 parts; Fructus Ligustri Lucidi 11 parts; Radix Camelliae sinensis 7 parts; Herba Dendrobii 17 parts; Rhizoma Polygonati Odorati 20 parts; Fructus Rubi 13 parts; Semen Cuscutae 14 parts; (forging) Concha Ostreae 5.5 parts.

The preparation method of above-mentioned hyperlipemic patients supplementing qi and invigorating vasculum oral medicine liquid, step is as follows:

(1) be placed in container by Cortex Eucommiae block, add saline and mix thoroughly (consumption of preferred salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, and with water spray fire extinguishing star, taking-up is dried, and grinds, and crosses 140 mesh sieves;

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the lamellar of thick 3mm, are placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water of 80 DEG C into, soak 30 minutes, filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 40 minutes, add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 30 minutes at every turn, twice filtrate merges, and leaves standstill 5 hours, gets supernatant;

(5) step (1) gained fine powder is joined step (4) gained medicated powder mix homogeneously, be concentrated into 1/2 of original volume, (consumption of sodium benzoate is 0.2% of concentrated solution quality to add sodium benzoate and correctives, correctives uses xylitol, consumption is 7% of concentrated solution quality), mixing, sterilizes 15 minutes, carries out sterile packaged with the dosage often propping up 6ml.

Instructions of taking: each one, every day 3 times, 7 days courses for the treatment of.

model case three:season XX, female, 67 years old, Liaocheng of Shandong Province Linqing City people.In retired employee's health check-up of a unit organization, detect that T-CHOL value is 6.94, be diagnosed as hyperlipidemia.Take him to sting class medicine and carry out blood fat reducing, after half wheat harvesting period, cholesterol has returned to normal level.See that cholesterol recovers normally, stops drug administration, after I had never expected one month, T-CHOL has gone up again, and this makes Mrs Ji very helpless.

After taking 2 courses for the treatment of of gained hyperlipemic patients supplementing qi and invigorating vasculum oral medicine liquid (embodiment 3) of the present invention, symptom slows down to some extent, has carried out blood fat chemical examination, and T-CHOL has dropped to 6.49.After continuing to take 2 courses for the treatment of, T-CHOL has dropped to 5.94, and malaise symptoms also disappears.Later stage visits and learns and there is no malaise symptoms.

embodiment 4hyperlipidemia hard masses softening and resolving medicine, takes off and states primary raw material and be prepared from (getting 20g for every part): the Cortex Eucommiae 12 parts; Herba Solani Nigri 7.5 parts; Fructus Amomi Rotundus 8 parts; Fructus Leonuri 10 parts; Radix Polygoni Multiflori 15 parts; Rhizoma Polygonati 18 parts; Root of Herba Apii graveolentis 7.5 parts; Radix Curcumae 10 parts; Herba Taxilli 7 parts; Semen arachidis hypogaeae herb 4.5 parts; Fructus Ligustri Lucidi 10 parts; Radix Camelliae sinensis 6 parts; Herba Dendrobii 15 parts; Rhizoma Polygonati Odorati 17 parts; Fructus Rubi 12 parts; Semen Cuscutae 13 parts; (forging) Concha Ostreae 5 parts.

The preparation method of above-mentioned hyperlipemic patients supplementing qi and invigorating vasculum drug capsule, step is as follows:

(1) be placed in container by Cortex Eucommiae block, add saline and mix thoroughly (consumption of preferred salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, and with water spray fire extinguishing star, taking-up is dried, and grinds, and crosses 140 mesh sieves;

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the lamellar of thick 3mm, are placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water of 80 DEG C into, soak 30 minutes, filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 40 minutes, add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 30 minutes at every turn, twice filtrate merges, and leaves standstill 5 hours, gets supernatant;

(5) join in step (4) gained filtrate by step (1) gained fine powder, mix homogeneously, being condensed into relative density is 1.30(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.5g/ grain, be processed into capsule according to the preparation for processing of capsule.

Instructions of taking: each 2-3 grain, every day 3 times, 7 days courses for the treatment of.

The pharmacological effect of each raw material is respectively:

The Cortex Eucommiae: acrid in the mouth, sweet, warm in nature.For the dry bark of the Eucommiaceae plant Cortex Eucommiae.There is invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.For spinal column ache, limbs flaccidity is weak, seminal emission, spermatorrhea, Diarrhoea, asthenia, dribbling urination, uncontrolled urination is itched, frequent fetal movement, vaginal bleeding during pregnancy for falling, overabundance of amniotic fluid, habitual abortion, hypertension.

Herba Solani Nigri: bitter in the mouth, micro-sweet, cold in nature.For the aerial parts of plant of Solanaceae Herba Solani Nigri.Containing solasonine, solamargine, β-solamargine etc.There is heat-clearing and toxic substances removing, effect of diuresis.For sore and toxic, skin eczema, dysuria, chronic senile tracheitis, leukorrhagia, prostatitis, dysentery.

Fructus Amomi Rotundus: acrid in the mouth, warm in nature.Return lung, spleen, stomach warp.For the dry mature fruit of zingiberaceous plant Fructus Amomi Rotundus.Containing volatile oil, wherein there are d-Borneolum Syntheticum, d-Camphora, Humuleno and epoxide thereof, 1, 8-Cineole, α-and δ-bat handkerchief alkene, α-and nopinene, caryophyllene, myrcene, myrtanal, Eucarvone, terpinene-4-alcohol, sabinene etc.There is circulation of qi promoting, warming the stomach, help digestion, effect of alleviating distention in middle-JIAO.For the stagnation of QI, dyspepsia, uncomfortable in chest, abdominal distention, eructation, dysphagic, tell inverse, regurgitation, malaria.

Fructus Leonuri: acrid in the mouth, hardship, cold nature.GUIXIN bag, Liver Channel.For the dry mature fruit of labiate Herba Leonuri.There is promoting blood flow to regulate menstruation, effect of liver heat removing and eyesight improving.For menoxenia, amenorrhea, dysmenorrhea, cataract, dizzy distending pain.

Radix Polygoni Multiflori: bitter in the mouth, sweet, puckery. warm in nature.Return liver, the heart, kidney channel.For the dried root of polygonum multiflorum thunb.There is removing toxic substances, disappear de-, effect of loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation, hyperlipidemia.

Rhizoma Polygonati: sweet in the mouth, property is put down.Return spleen, lung, kidney channel.For the dry rhizome of liliaceous plant P. kingianum, Rhizoma Polygonati or Polygonatum cyrtonema Hua.There is boosting qi and nourishing yin, spleen invigorating, lung moistening, effect of kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.

Root of Herba Apii graveolentis: sweet in the mouth, cool in nature.For the root of samphire Herba Apii graveolentis.Containing more dietary fiber, vitamin and phosphorus, calcium etc.There is promoting blood circulation to remove obstruction in the collateral, removing toxic substances, heat clearing away, diuresis, effect of blood pressure lowering.For hypertension, insomnia, the diseases such as tracheitis.

Radix Curcumae: acrid in the mouth, hardship, cold in nature.For the dried root of zingiberaceous plant RADIX CURCUMAE, Rhizoma Curcumae Longae, Guangxi zedoary or Rhizoma Curcumae.Return liver, the heart, lung meridian.There is regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.

Herba Taxilli: bitter in the mouth, sweet, property is put down.Return liver, kidney channel.For Loranthaceae plant kills the dry stem and branch with leaf of parasitic youngster.There is invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, effect of antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement, hypertension.

Semen arachidis hypogaeae herb: the dry herb of Papilionaceae Arachis annual herb plant Semen arachidis hypogaeae.Have heat clearing away benefit blood, blood pressure lowering, reduces effect of cholesterol.Be used for the treatment of vascular hypertension, neurasthenia, lie awake all night, insomnia and dreamful sleep, be easy to wake up with a start, distending pain in the head, palpitation and amnesia, lack of appetite.

Fructus Ligustri Lucidi: sweet in the mouth, hardship, cool in nature.Return liver, kidney channel.For the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.There is nourishing the liver and kidney, effect of improving eyesight black hair.For Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.

Radix Camelliae sinensis: bitter in the mouth, property is put down.GUIXIN, kidney channel.For the root of plant of theaceae tea.Containing saccharides such as stachyose, Raffinose, sucrose, glucose, fructose, and containing a small amount of polyphenolic substance (flavonol etc.).Leaf, branch, stem all contain flavonol and caffeine, and content is from leaf to stem all, reduces successively from top to bottom, and stem is containing volume l-epicatechin.There is heart tonifying diuresis, promoting blood flow to regulate menstruation, effect of heat-clearing and toxic substances removing.For heart disease, edema, hepatitis, dysmenorrhea, sore swollen toxin, aphtha, soup fire is burnt, herpes zoster, psoriasis.

Herba Dendrobii: sweet in the mouth, cold nature.For the fresh or dry stem of orchid gold silver five dry measure used in former times, iron sheet building stones or Herba Dendrobii oculati and allied species thereof.Return stomach, kidney channel.There is reinforcing stomach reg fluid, effect of nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.

Rhizoma Polygonati Odorati: sweet in the mouth, cold nature.Attach to the lung and stomach meridians.For the dry rhizome of liliaceous plant Rhizoma Polygonati Odorati.There is nourishing YIN to relieve dryness, effect of promoting the production of body fluid to quench thirst.For lung stomach-Yin wound, cough caused by dryness-heat, swallow in thirsty, interior-heat is quenched one's thirst.

Fructus Rubi: sweet in the mouth, acid, warm in nature.Return kidney, urinary bladder channel.For the dry fruit of rosaceous plant rubus chingii Hu.There is kidney tonifying, controlling nocturnal emission with astringent drugs, effect of reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.

Semen Cuscutae: sweet in the mouth, warm in nature.Return liver,kidney,spleen warp.For the dry mature seed of convolvulus cuscuta plant.There is nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, effect of antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.

(forging) Concha Ostreae: Concha Ostreae (calcined) is the calcining product of Concha Ostreae, Concha Ostreae salty in the mouth, cold nature.Return liver, gallbladder, kidney channel.For the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating effect.For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

test example:in order to verify the curative effect of gained hyperlipemic patients supplementing qi and invigorating vasculum medicament (embodiment 4) of the present invention, we have done contrast test in April ,-2012 in May, 2008.

General data: the patient screening 200 routine hyperlipidemia in Duo Suo hospital, man 106 example, female 94 example; Minimal ages 36 years old, max age 68 years old, 49.4 years old mean age; 36-50 year 76 people, 50-68 year 124 people; Build overweight people 149 example, medium person 49 example, thin 2 example.The shortest person of the course of disease about 10 days, most elder 4 years.Be divided into experimental group and matched group Liang Ge group (wherein, experimental group 150 people, matched group 50 people) at random.Two groups of ordinary circumstances compare, no significant difference (P > 0.05).

Diagnostic criteria: with reference to " new Chinese medicine guideline of clinical investigations ": (1) Western medicine diagnose standard: in normal diet situation, 2 weeks interior survey for 2 times serum total cholesterol (TC) all >=6.0mmol/L(230mg/dL), or triglyceride (TG) >=1.54mmol/L(140mg/dL), or HDL-C (HDL-C) man≤1.04mmol/L(40mg/dL), female≤1.17mmol/L(45mg/dL) person.(2) Standards of Chinese Medical Syndrome Differentiation: dizzy, headache, uncomfortable in chest, face purple lip is dark, spiritlessness and weakness, extremities being not warm, distension and fullness in the abdomen, indigestion and loss of appetite loose stool, soreness of the waist and knees, dimly red tongue or purple dark or have petechia ecchymosis or have that tooth prints, Tai Bai or greasy in vain, deep-thready pulse or heavy.

Usage and dosage: two groups of patients unify dietary standards (strictly controlling the absorption of wine, meat, sugar).Experimental group takes gained hyperlipemic patients supplementing qi and invigorating vasculum drug capsule of the present invention, each 2, every day 3 times, 7 days courses for the treatment of.Matched group: adopt other treatment mode (as Compound Daushen Lozenge, JIANGZHINING KELI etc.), wherein Compound Daushen Lozenge containing change, one time 2,3 times on the one; JIANGZHINING KELI, oral, a 10g(1 bag), 3 times on the one.

Criterion of therapeutical effect: with reference to " new Chinese medicine guideline of clinical investigations ": cure: clinical symptoms, sign disappear; the every inspection of laboratory recovers normal or lipids detection reaches following any one person: TC declines >=20%; TG declines >=40%; HDL-C rising >=0.26mmol/L (10mg/dL), TC-HDL-C/HDL-C decline >=20%.Effective: clinical symptoms, sign all take a favorable turn, lipids detection reaches following any one person: TC declines >=10% but < 20%, TG declines >=20% but < 40%, HDL-C rising >=0.104mmol/L (4mg/dL) but < 0.26mmol/L (10mg/dL), TC-HDL-C/HDL-C decline >=10% but < 20%.Invalid: after treatment, symptom, sign and lipids detection are without improvement.

5 courses for the treatment of of medication treatment, observe latter 3 months for the treatment of.The Comparison of therapeutic of the matched group adopting other treatment mode and the experimental group taking gained hyperlipemic patients supplementing qi and invigorating vasculum medicament of the present invention, result is as shown in table 1:

Table 1

efficacy analysis:as can be seen from Table 1, take the effective percentage of gained hyperlipemic patients supplementing qi and invigorating vasculum medicament of the present invention up to 96.67%, and adopt other treatment mode only reach 80%, and take the cure rate of gained hyperlipemic patients supplementing qi and invigorating vasculum medicament of the present invention up to 70.67%, and adopt the cure rate of other treatment mode only to reach 46%.Show that the curative effect of gained hyperlipemic patients supplementing qi and invigorating vasculum medicament of the present invention is more remarkable.

Continuous medication treatment chemically examines blood fat after 5 courses for the treatment of, result as shown in Table 2-4:

Table 2 liang group triglyceride (TG) test and comparison (mmol/L)

Two groups of triglyceride (TG) changes: before two groups of treatments, triglyceride (TG) compares P > 0.05, no significant difference; Self compare before and after two groups of treatments, equal P < 0.01; Two groups of difference comparsion P < 0.05 after treatment, and experimental group on average reduce 2.39, matched group on average reduces 1.52, and the normal reference value 0.4-1.86mmol/L of triglyceride (TG), experimental group is taken medicine after 5 courses for the treatment of, the content of triglyceride (TG) is to reach normal level, and matched group does not reach normal level.Therefore experimental group reduction triglyceride (TG) curative effect is better than matched group.

Table 3 liang group serum total cholesterol (TC) test and comparison (mmol/L)

Two groups of serum total cholesterol (TC) changes: before two groups of treatments, serum total cholesterol (TC) compares P > 0.05, no significant difference; Self compare before and after two groups of treatments, equal P < 0.01; Two groups of difference comparsion P < 0.05 after treatment, and the average reduction by 20.63 of experimental group, matched group on average reduces 16.18, and the normal reference value 3.89-6.48mmol/L of serum total cholesterol (TC), experimental group is taken medicine after 5 courses for the treatment of, the content of serum total cholesterol (TC) is to reach normal level, and matched group does not reach normal level.Therefore experimental group reduction serum total cholesterol (TC) curative effect is better than matched group.

Table 4 liang group HDL-C (HDL-C) test and comparison (mmol/L)

Two groups of HDL-C (HDL-C) changes: before two groups of treatments, HDL-C (HDL-C) compares P > 0.05, no significant difference; Self compare before and after two groups of treatments, equal P < 0.01; Two groups of difference comparsion P < 0.05 after treatment, and experimental group on average improve 0.52, matched group on average improves 0.11, and HDL-C (HDL-C) normal reference value 1.04-1.74mmol/L, experimental group is taken medicine after 5 courses for the treatment of, the content of HDL-C (HDL-C) is to reach normal level, and matched group does not reach normal level.Therefore experimental group raising HDL-C (HDL-C) curative effect is better than matched group.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. hyperlipemic patients supplementing qi and invigorating vasculum medicament, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Cortex Eucommiae 10-15 part; Herba Solani Nigri 6-9 part; Fructus Amomi Rotundus 5-10 part; Fructus Leonuri 8-12 part; Radix Polygoni Multiflori 10-20 part; Rhizoma Polygonati 12-25 part; Root of Herba Apii graveolentis 6-9 part; Radix Curcumae 8-12 part; Herba Taxilli 5-10 part; Semen arachidis hypogaeae herb 3-6 part; Fructus Ligustri Lucidi 8-12 part; Radix Camelliae sinensis 4-8 part; Herba Dendrobii 10-20 part; Rhizoma Polygonati Odorati 10-25 part; Fructus Rubi 8-16 part; Semen Cuscutae 10-15 part; (forging) Concha Ostreae 4-6 part.

2. hyperlipemic patients supplementing qi and invigorating vasculum medicament according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Cortex Eucommiae 11-14 part; Herba Solani Nigri 7-8 part; Fructus Amomi Rotundus 6-9 part; Fructus Leonuri 9-11 part; Radix Polygoni Multiflori 13-17 part; Rhizoma Polygonati 17-20 part; Root of Herba Apii graveolentis 7-8 part; Radix Curcumae 9-11 part; Herba Taxilli 6-9 part; Semen arachidis hypogaeae herb 4-5 part; Fructus Ligustri Lucidi 9-11 part; Radix Camelliae sinensis 5-7 part; Herba Dendrobii 13-17 part; Rhizoma Polygonati Odorati 15-20 part; Fructus Rubi 11-13 part; Semen Cuscutae 11-14 part; (forging) Concha Ostreae 4.5-5.5 part.

3. hyperlipemic patients supplementing qi and invigorating vasculum medicament according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: the Cortex Eucommiae 12 parts; Herba Solani Nigri 7.5 parts; Fructus Amomi Rotundus 8 parts; Fructus Leonuri 10 parts; Radix Polygoni Multiflori 15 parts; Rhizoma Polygonati 18 parts; Root of Herba Apii graveolentis 7.5 parts; Radix Curcumae 10 parts; Herba Taxilli 7 parts; Semen arachidis hypogaeae herb 4.5 parts; Fructus Ligustri Lucidi 10 parts; Radix Camelliae sinensis 6 parts; Herba Dendrobii 15 parts; Rhizoma Polygonati Odorati 17 parts; Fructus Rubi 12 parts; Semen Cuscutae 13 parts; (forging) Concha Ostreae 5 parts.

4., according to the arbitrary described hyperlipemic patients supplementing qi and invigorating vasculum medicament of claim 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is:

(1) be placed in container by Cortex Eucommiae block, add saline and mix thoroughly, exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, and with water spray fire extinguishing star, taking-up is dried, and grinds, and crosses 120-160 mesh sieve (preferred cross 130-150 mesh sieve, be more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) step (1) gained fine powder is joined in step (4) gained filtrate, mix homogeneously, filter, sterile packaged.

5. the preparation method of hyperlipemic patients supplementing qi and invigorating vasculum medicament decoction according to claim 4, it is characterized in that: the consumption of step (1) preferred salt is the 2%-4% of Cortex Eucommiae quality, the consumption being more preferably salt is 3% of Cortex Eucommiae quality.

6., according to the arbitrary described hyperlipemic patients supplementing qi and invigorating vasculum medicament of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:

(1) Cortex Eucommiae block is placed in container, add saline and mix that (consumption of preferred salt is the 2%-4% of Cortex Eucommiae quality thoroughly, the consumption being more preferably salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, with water spray fire extinguishing star, taking-up is dried, grind, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) step (1) gained fine powder is joined in step (4) gained filtrate, mix homogeneously, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste (be preferably condensed into the thick paste that relative density is 1.25-1.35, be more preferably and be condensed into the thick paste that relative density is 1.30), make the namely loose soft material that hands pinches agglomerating pressure, make uniform granule, dry, be pressed into lamellar, sugar coating.

7., according to the arbitrary described hyperlipemic patients supplementing qi and invigorating vasculum medicament of claim 1-3, it is characterized in that, the preparation method of described oral liquid, step is as follows:

(1) Cortex Eucommiae block is placed in container, add saline and mix that (consumption of preferred salt is the 2%-4% of Cortex Eucommiae quality thoroughly, the consumption being more preferably salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, with water spray fire extinguishing star, taking-up is dried, grind, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) step (1) gained fine powder is joined step (4) gained medicated powder mix homogeneously, be concentrated into 1/2 of original volume, add sodium benzoate and correctives, mixing, sterilize 10-20 minute (preferred 13-17 minute is more preferably 15 minutes), carries out sterile packaged with the dosage often propping up 6ml.

8. the preparation method of hyperlipemic patients supplementing qi and invigorating vasculum oral medicine liquid according to claim 7, it is characterized in that: the consumption of step (5) preferred sodium benzoate is the 0.1%-0.3% of concentrated solution quality, correctives uses xylitol, consumption is the 6%-8% of concentrated solution quality, the consumption being more preferably sodium benzoate is 0.2% of concentrated solution quality, correctives uses xylitol, and consumption is 7% of concentrated solution quality.

9., according to the arbitrary described hyperlipemic patients supplementing qi and invigorating vasculum medicament of claim 1-3, it is characterized in that, the preparation method of described capsule, step is as follows:

(1) Cortex Eucommiae block is placed in container, add saline and mix that (consumption of preferred salt is the 2%-4% of Cortex Eucommiae quality thoroughly, the consumption being more preferably salt is 3% of Cortex Eucommiae quality), exhaust in rearmounted pot, intense fire is fried to black and fracture of wire sustainability, with water spray fire extinguishing star, taking-up is dried, grind, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(2) Radix Polygoni Multiflori, Rhizoma Polygonati, root of Herba Apii graveolentis, Radix Curcumae and Radix Camelliae sinensis are cut into the preferred 2.5-3.5mm of thick 2-4mm(, be more preferably 3mm) lamellar, be placed in non iron container, add rice wine moistening stand-by (rice wine of preferred 40o-50o is more preferably the rice wine of 45o);

(3) Rhizoma Polygonati Odorati is put into glass container, pour the hot water (the preferably hot water of 75 DEG C-85 DEG C, is more preferably the hot water of 80 DEG C) of 70 DEG C-90 DEG C into, soak 20-40 minute (preferably soak 25-35 minute, be more preferably immersion 30 minutes), filter, filtrate is for subsequent use;

(4) Concha Ostreae (will be forged) to smash, be placed in marmite, add Herba Solani Nigri and Semen Cuscutae, decoct with water 30-50 minute (preferred 35-45 minute, be more preferably 40 minutes), add step (2) gains, step (3) gained filtrate, Fructus Amomi Rotundus, Fructus Leonuri, Herba Taxilli, Semen arachidis hypogaeae herb, Fructus Ligustri Lucidi, Herba Dendrobii and Fructus Rubi, continue decoction twice, boil 20-40 minute (preferred 25-35 minute at every turn, be more preferably 30 minutes), twice filtrate merges, and leaves standstill 3-7 hour (preferred 4-6 hour, be more preferably 5 hours), get supernatant;

(5) join in step (4) gained filtrate by step (1) gained fine powder, mix homogeneously, being condensed into relative density is 1.20-1.40(45 DEG C) thick paste, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is measured according to 0.4-0.6g/ grain (preferred 0.45-0.55g/ grain, is more preferably 0.5g/ grain), be processed into capsule according to the preparation for processing of capsule.

10. the preparation method of hyperlipemic patients supplementing qi and invigorating vasculum drug capsule according to claim 9, is characterized in that: step (5) is preferably concentrated into the thick paste of relative density 1.25-1.35, is more preferably the thick paste being concentrated into relative density 1.30.