CN104547933A - Traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
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- CN104547933A CN104547933A CN201510014162.5A CN201510014162A CN104547933A CN 104547933 A CN104547933 A CN 104547933A CN 201510014162 A CN201510014162 A CN 201510014162A CN 104547933 A CN104547933 A CN 104547933A
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Abstract
The invention discloses a traditional Chinese medicine composition as well as a preparation method and an application thereof. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 307-317 parts of astragalus membranaceus, 620-630 parts of rhizoma corydalis processed with vinegar, 307-317 parts of angelica sinensis, 370-380 parts of radix paeoniae rubra, 307-317 parts of salvia miltiorrhiza, 307-317 parts of ligusticum wallichii, 307-317 parts of curcuma zedoary, 245-255 parts of hematoxylon, 307-317 parts of caulis spatholobi and 200-600 parts of a pharmaceutically acceptable carrier. The traditional Chinese medicine composition is great in treatment effect on varicose vein of lower limbs in preparation for medicines for treating varicose vein of lower limb.
Description
Technical field
The invention belongs to technical field of medicine, particularly, the present invention relates to a kind of Chinese medicine composition and its preparation method and application.
Background technology
The many superficial vein blood flow reflux caused due to superficial vein first pair of valve (stock saphena valve) incompetence of varicose veins of the lower extremity, increase the disease that veins of lower extremity pressure causes.Geneogenous wall of vein weakness is also major reason, and patient is often associated with the whole body or circumscribed wall of vein defect, when vein pressure increases, just produces tortuous, the expansion of vein.Stand for a long time, fat and abdominal pressure etc. because of procatarxis can increase that vein pressure all can increase that varicosis development occurs may.Morbidity is early stage, mostly is the lower limb swollen discomfort of acid and dull pain sense, has limbs sense of heaviness simultaneously, easily weak.How above-mentionedly behind station for a long time feel to increase the weight of, then can be alleviated by flat sleeping, limb lifting.Pathological changes middle and late stage, wall of vein is impaired, vein protuberance, expansion, tortuous, in Lumbricus sample outward appearance, with the traveling of medial leg great saphenous vein, district is obvious.Course of disease elder, limb skin then occurs that trophism changes, and as desquamation, pruritus, pigmentation etc., even forms eczema and ulcer.Along with the differentiation of the state of an illness, can with the symptom such as pain, lower extremity swelling and distension, stasis dermatitis, superficial vein thrombosis of blood vessel traveling.The improvement of existing medicine to above-mentioned symptom is out of condition.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition is good to varicose veins of the lower extremity therapeutic effect.
For achieving the above object, the technical solution used in the present invention is as follows:
A kind of Chinese medicine composition, described Chinese medicine composition primarily of part by weight be Radix Astragali 307-317 part, Rhizoma Corydalis (processed with vinegar) 620-630 part, Radix Angelicae Sinensis 307-317 part, Radix Paeoniae Rubra 370-380 part, Radix Salviae Miltiorrhizae 307-317 part, Rhizoma Chuanxiong 307-317 part, Rhizoma Curcumae 307-317 part, Lignum Sappan 245-255 part, Caulis Spatholobi 307-317 part and pharmaceutically acceptable carrier 200 ~ 600 parts raw material make.
Preferably, described Chinese medicine composition primarily of part by weight be the Radix Astragali 312 parts, Rhizoma Corydalis (processed with vinegar) 625 parts, Radix Angelicae Sinensis 312 parts, Radix Paeoniae Rubra 375 parts, Radix Salviae Miltiorrhizae 312 parts, Rhizoma Chuanxiong 312 parts, Rhizoma Curcumae 312 parts, Lignum Sappan 250 parts, Caulis Spatholobi 312 parts and pharmaceutically acceptable carrier 200 ~ 600 parts raw material make.
Another object of the present invention is, provides the application of above-mentioned Chinese medicine composition in preparation treatment varicose veins of the lower extremity medicine.
In technique scheme, described vinegar Hu Yansuo refers to and to be prepared according to " Chinese Pharmacopoeia one " (version in 2010) the 130th page and annex 20,21 pages of contents.
As the improvement to the Chinese medicine composition described in technique scheme, wherein said pharmaceutically acceptable carrier can be the combination of one or more of dextrin, starch, cellulose, starch or cellulosic derivant etc.
Another object of the present invention is, provides the preparation method of the Chinese medicine composition described in technique scheme, said method comprising the steps of:
1) each crude drug of described weight portion is taken;
2) 70% alcohol heat reflux that Rhizoma Corydalis (processed with vinegar) adds 6 times amount extracts 3 hours, and reclaiming ethanol and being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20;
3) get Radix Salviae Miltiorrhizae and add ethanol 6 times amount, circumfluence distillation 2 hours, filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20, medicinal residues water 8 times amount, circumfluence distillation 2 hours, filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20;
4) by the Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Curcumae, Lignum Sappan and Caulis Spatholobi mixing, add water 8 times amount circumfluence distillation 3 hours, and filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20;
5) using pharmaceutically acceptable carrier as base material, put in Fluidbedgranulatingdrier; By step 2)-4) mixing of the thick paste prepared, spray into Fluidbedgranulatingdrier, granulate dry, to obtain final product.
The preparation method of the Chinese medicine preparation described in technique scheme, wherein said pharmaceutically acceptable carrier can be the combination of one or more of dextrin, starch, cellulose, starch or cellulosic derivant etc.
Chinese medicine composition of the present invention and preparation thereof effectively can treat varicose veins of the lower extremity.
Detailed description of the invention
Be convenient to for making technical scheme of the present invention understand, below in conjunction with detailed description of the invention, the present invention is further illustrated.
Embodiment 1:
Radix Astragali 307g, Rhizoma Corydalis (processed with vinegar) 620g, Radix Angelicae Sinensis 307g, Radix Paeoniae Rubra 370g, Radix Salviae Miltiorrhizae 307g, Rhizoma Chuanxiong 307g, Rhizoma Curcumae 307g, Lignum Sappan 245g, Caulis Spatholobi 307g.Above nine tastes, 70% alcohol heat reflux that Rhizoma Corydalis (processed with vinegar) adds 6 times amount extracts 3 hours, and reclaiming ethanol and being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; Get Radix Salviae Miltiorrhizae and add ethanol 6 times amount, circumfluence distillation 2 hours, filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20, and medicinal residues add water 8 times amount, circumfluence distillation 2 hours, filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; By the Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Curcumae, Lignum Sappan and Caulis Spatholobi mixing, add water 8 times amount circumfluence distillation 3 hours, and filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; Using the dextrin of 200g as base material, put in Fluidbedgranulatingdrier; The thick paste of above-mentioned preparation is mixed, sprays into Fluidbedgranulatingdrier, granulate dry.Be divided into 142 parts by after dried granule granulate, be packaged into bag respectively, each bag is a dosage.
Embodiment 2:
Radix Astragali 317g, Rhizoma Corydalis (processed with vinegar) 630g, Radix Angelicae Sinensis 317g, Radix Paeoniae Rubra 380g, Radix Salviae Miltiorrhizae 317g, Rhizoma Chuanxiong 317g, Rhizoma Curcumae 317g, Lignum Sappan 255g, Caulis Spatholobi 317g.Above nine tastes, 70% alcohol heat reflux that Rhizoma Corydalis (processed with vinegar) adds 6 times amount extracts 3 hours, and reclaiming ethanol and being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; Get Radix Salviae Miltiorrhizae and add ethanol 6 times amount, circumfluence distillation 2 hours, filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20, medicinal residues water 8 times amount, circumfluence distillation 2 hours, filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; By the Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Curcumae, Lignum Sappan and Caulis Spatholobi mixing, add water 8 times amount circumfluence distillation 3 hours, and filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; Using the mixing of the dextrin of 600g as base material, put in Fluidbedgranulatingdrier; The thick paste of above-mentioned preparation is mixed, sprays into Fluidbedgranulatingdrier, granulate dry.Be divided into 142 parts by after dried granule granulate, be packaged into bag respectively, each bag is a dosage.
Embodiment 3:
Radix Astragali 312g, Rhizoma Corydalis (processed with vinegar) 625g, Radix Angelicae Sinensis 312g, Radix Paeoniae Rubra 375g, Radix Salviae Miltiorrhizae 312g, Rhizoma Chuanxiong 312g, Rhizoma Curcumae 312g, Lignum Sappan 250g, Caulis Spatholobi 312g.Above nine tastes, 70% alcohol heat reflux that Rhizoma Corydalis (processed with vinegar) adds 6 times amount extracts 3 hours, and reclaiming ethanol and being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; Get Radix Salviae Miltiorrhizae and add ethanol 6 times amount, circumfluence distillation 2 hours, filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20, medicinal residues water 8 times amount, circumfluence distillation 2 hours, filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20; By the Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Flos Carthami, Lignum Sappan and Caulis Spatholobi mixing, add water 8 times amount circumfluence distillation 3 hours, and filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15-1.20; Using the dextrin of 400g as base material, put in Fluidbedgranulatingdrier; The thick paste of above-mentioned preparation is mixed, sprays into Fluidbedgranulatingdrier, granulate dry.Be divided into 142 parts by after dried granule granulate, be packaged into bag respectively, each bag is a dosage.
Chinese medicine preparation of the present invention is set forth further for the preparation of the beneficial effect had during treatment varicose veins of the lower extremity medicine below by way of concrete test example:
One, method
1. clinical data
According to " clinic diagnosis guide-surgery's fascicle ", the diagnostic criteria of ecthyma in " disease of tcm Standardization of diagnosis and curative effect ", patient 30 example that selection is diagnosed as varicose veins of the lower extremity, clinical syndrome differentiation is qi stagnation and blood stasis type, include this research in:
Case selection inclusive criteria: (1), meet Chinese and western medicine diagnostic criteria; (2), deep veins of lower limb ultrasonic prompting Muscular loop function is normal, without thrombosis; (3), 40-70 years old.
Exclusion standard: (1), diabetes and other serious disease persons; (2) person that, has deep vein thrombosis of lower extremity; (3), the varicose veins of the lower extremity of other secondary causes.
Therapeutic Method: all patients gives the embodiment 1-3 Chinese medicine composition prepared, 1 bag/time, 3 times/day, 8 weeks courses for the treatment of.
Observation index: main clinic symptoms change (lower extremity swelling and distension heavy, rope bar, pigmentation) of observing treatment Patients Before And After.Hemorheology change before and after lab testing treatment.Prohibit the use other to have blood circulation promoting and blood stasis dispelling during all patient treatments, promote the medicine of microcirculation.
2. statistical method
All data all adopt SPSS13.0 statistical analysis software to carry out variance analysis, and result x ± s represents, are that difference has statistical significance with P<0.05.
Two, result
1. before and after treatment, cardinal symptom changes
30 routine patients are after treatment, and cardinal symptom swelling is heavy, rope bar, pigmentation are all improved before comparatively treating, and has significant difference.In table 1.
Table 1. is treated front and back cardinal symptom and is improved situation [number of cases (%)]
| Project | Number of cases | Disappear | Improve | Unchanged |
| Swelling is heavy | 30 | 10(33.3) | 18(60.0) | 2(6.7) |
| Rope bar | 30 | 6(20.0) | 22(73.3) | 2(6.7) |
| Pigmentation | 30 | 7(23.3) | 19(63.3) | 4(13.3) |
2, hemorheology situation of change before and after treatment
After treatment, the hemorheology of patient improves obviously, and blood viscosity, packed cell volume, Fibrinogen, erythrocyte sedimentation rate are all significantly improved before comparatively treating.In table 2.
Table 2. treat Patients Before And After hemorheology situation of change (n=30,
)
| Project | Before treatment | After treatment |
| Whole blood viscosity is high cuts (mpa.s) | 5.52±0.75 | 2.81±0.78** |
| Whole blood viscosity is low cuts (mpa.s) | 12.53±1.67 | 8.23±1.79* |
| Plasma viscosity (mpa.s) | 2.61±0.39 | 1.45±0.42** |
| Packed cell volume (%) | 48.39±5.56 | 41.96±5.77* |
| Fibrinogen (g/L) | 4.39±1.28 | 3.11±1.25* |
| Erythrocyte sedimentation rate (mm/h) | 26.97±10.20 | 17.35±8.16* |
Compare with before treatment, * p < 0.05, * * p < 0.01
Three, conclusion
Varicose veins of the lower extremity is because of superficial veins of lower limb valve insufficiency, makes intravenous thrombosis, and the distal vein stasis of blood is stagnant, and wall of vein expansion then, occurs irregular expansion and distortion, cause caused by superficial veins of lower limb congestion.Chinese medicine composition function benefiting QI for activating blood circulation of the present invention, promoting tissue regeneration by removing blood stasis, removing obstruction in the collateral to relieve pain, can blood circulation promoting, improves the vein stasis of blood stagnant.This observed result shows, the cardinal symptoms such as Chinese medicine composition of the present invention is heavy to elimination patient swelling, rope bar, pigmentation have obvious effect, after treatment, hemorheological indexes is also all significantly improved, thus illustrates that Chinese medicine composition of the present invention has good curative effect to varicose veins of the lower extremity.
It should be noted last that, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted.Although with reference to embodiment to invention has been detailed description, will be understood by those skilled in the art that, modify to technical scheme of the present invention or equivalent replacement, do not depart from the spirit and scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (5)
1. a Chinese medicine composition, it is characterized in that, described Chinese medicine composition primarily of part by weight be Radix Astragali 307-317 part, Rhizoma Corydalis (processed with vinegar) 620-630 part, Radix Angelicae Sinensis 307-317 part, Radix Paeoniae Rubra 370-380 part, Radix Salviae Miltiorrhizae 307-317 part, Rhizoma Chuanxiong 307-317 part, Rhizoma Curcumae 307-317 part, Lignum Sappan 245-255 part, Caulis Spatholobi 307-317 part and pharmaceutically acceptable carrier 200 ~ 600 parts raw material make.
2. a kind of Chinese medicine composition according to claim 1, it is characterized in that, described Chinese medicine composition primarily of part by weight be the Radix Astragali 312 parts, Rhizoma Corydalis (processed with vinegar) 625 parts, Radix Angelicae Sinensis 312 parts, Radix Paeoniae Rubra 375 parts, Radix Salviae Miltiorrhizae 312 parts, Rhizoma Chuanxiong 312 parts, Rhizoma Curcumae 312 parts, Lignum Sappan 250 parts, Caulis Spatholobi 312 parts and pharmaceutically acceptable carrier 200 ~ 600 parts raw material make.
3. Chinese medicine composition according to claim 1 and 2, is characterized in that, described pharmaceutically acceptable carrier is the combination of one or more in dextrin, starch, cellulose and its derivates.
4. the preparation method of the arbitrary described Chinese medicine composition of claim 1-3, said method comprising the steps of:
1) each crude drug of described weight portion is taken;
2) 70% alcohol heat reflux that Rhizoma Corydalis (processed with vinegar) adds 6 times amount extracts 3 hours, and reclaiming ethanol and being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20;
3) get Radix Salviae Miltiorrhizae and add ethanol 6 times amount, circumfluence distillation 2 hours, filter, reclaim ethanol, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20, medicinal residues water 8 times amount, circumfluence distillation 2 hours, filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20;
4) by the Radix Astragali, Radix Angelicae Sinensis, Radix Paeoniae Rubra, Rhizoma Chuanxiong, Rhizoma Curcumae, Lignum Sappan and Caulis Spatholobi mixing, add water 8 times amount circumfluence distillation 3 hours, and filter, being evaporated to 60 DEG C of relative densities is the thick paste of 1.15 ~ 1.20;
5) using pharmaceutically acceptable carrier as base material, put in Fluidbedgranulatingdrier; By step 2)-4) mixing of the thick paste prepared, spray into Fluidbedgranulatingdrier, granulate dry, to obtain final product.
5. the application of the arbitrary described Chinese medicine composition of claim 1-3 in preparation treatment varicose veins of the lower extremity medicine.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888104A (en) * | 2015-05-22 | 2015-09-09 | 青岛市胶州中心医院 | Pharmaceutical composition for nursing and treating varicose veins and preparation method of pharmaceutical composition |
| CN105726895A (en) * | 2016-05-10 | 2016-07-06 | 郑植 | Traditional Chinese medicine for treating varicosity |
| CN115770279A (en) * | 2022-11-24 | 2023-03-10 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating chronic lower limb venous diseases and decoction and preparation thereof |
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| GB2051576A (en) * | 1979-07-05 | 1981-01-21 | Geistlich Soehne Ag Fur Chemis | Compositions for the care of the legs |
| CN103860741A (en) * | 2012-12-13 | 2014-06-18 | 青岛信立德中药技术研究开发有限公司 | Lower limb varicose vein treatment traditional Chinese medicine |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB2051576A (en) * | 1979-07-05 | 1981-01-21 | Geistlich Soehne Ag Fur Chemis | Compositions for the care of the legs |
| CN103860741A (en) * | 2012-12-13 | 2014-06-18 | 青岛信立德中药技术研究开发有限公司 | Lower limb varicose vein treatment traditional Chinese medicine |
Non-Patent Citations (2)
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888104A (en) * | 2015-05-22 | 2015-09-09 | 青岛市胶州中心医院 | Pharmaceutical composition for nursing and treating varicose veins and preparation method of pharmaceutical composition |
| CN104888104B (en) * | 2015-05-22 | 2018-05-25 | 青岛市胶州中心医院 | One kind is for cirsoid pharmaceutical composition of nursing for treating and preparation method thereof |
| CN105726895A (en) * | 2016-05-10 | 2016-07-06 | 郑植 | Traditional Chinese medicine for treating varicosity |
| CN115770279A (en) * | 2022-11-24 | 2023-03-10 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating chronic lower limb venous diseases and decoction and preparation thereof |
| CN115770279B (en) * | 2022-11-24 | 2023-11-21 | 上海中医药大学附属曙光医院 | Traditional Chinese medicine composition for treating chronic lower limb vein diseases, decoction and preparation thereof |
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